dinoprost

Summary

Summary: A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.

Top Publications

  1. pmc Prostaglandin F(2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathway
    Kurt J Sales
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4TJ, UK
    Biochim Biophys Acta 1793:1917-28. 2009
  2. ncbi Isoprostanes: an overview and putative roles in pulmonary pathophysiology
    L J Janssen
    Asthma Research Group, Father Sean O Sullivan Research Center, St Joseph s Hospital, McMaster University, 50 Charlton Ave East, Hamilton, Ontario L8N 4A6, Canada
    Am J Physiol Lung Cell Mol Physiol 280:L1067-82. 2001
  3. ncbi Inherited human gp91phox deficiency is associated with impaired isoprostane formation and platelet dysfunction
    Pasquale Pignatelli
    Department of Internal Medicine and Medical Specialties, I Clinica Medica, University of Rome La Sapienza, Viale del Policlinico 155, Rome, Italy
    Arterioscler Thromb Vasc Biol 31:423-34. 2011
  4. ncbi Effect of prostaglandin F2 alpha on local luteotropic and angiogenic factors during induced functional luteolysis in the bovine corpus luteum
    Bajram Berisha
    Physiology Weihenstephan, Technical University Munich, Freising, Germany
    Biol Reprod 82:940-7. 2010
  5. ncbi Regulation of oxidative stress by glycaemic control: evidence for an independent inhibitory effect of insulin therapy
    L Monnier
    Laboratory of Human Nutrition and Atherogenesis, University Institute of Clinical Research, 34093 Montpellier Cedex 5, France
    Diabetologia 53:562-71. 2010
  6. ncbi Regulation of endometrial prostaglandin F(2alpha) synthesis during luteolysis and early pregnancy in cattle
    K Okuda
    Laboratory of Reproductive Endocrinology, Faculty of Agriculture, Okayama University, Japan
    Domest Anim Endocrinol 23:255-64. 2002
  7. ncbi Requirement of cyclooxygenase-2 expression and prostaglandins for human prostate cancer cell invasion
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Clin Exp Metastasis 19:593-601. 2002
  8. ncbi Prostaglandin F2alpha increases endothelial nitric oxide synthase in the periphery of the bovine corpus luteum: the possible regulation of blood flow at an early stage of luteolysis
    Koumei Shirasuna
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080 8555, Japan
    Reproduction 135:527-39. 2008
  9. pmc Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin f(2α) impairs endothelial function in renovascular hypertensive rats
    Xiao Yu Tian
    Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong SAR, China
    Antioxid Redox Signal 16:363-73. 2012
  10. ncbi Reduction in extracellular superoxide dismutase activity in African-American patients with hypertension
    Lichun Zhou
    Division of Cardiovascular Biology, Department of Biomedical Sciences, Meharry Medical College, Nashville, TN 37208, USA
    Free Radic Biol Med 41:1384-91. 2006

Research Grants

  1. PG-INDUCED REDUCTION OF INTRAOCULAR PRESSURE
    Carl Camras; Fiscal Year: 1993
  2. OVULATION--STUDIES USING IN VITRO PERFUSED OVARIES
    Edward Wallach; Fiscal Year: 1992
  3. STRETCH CHANGES IN THE RABBIT CERVIX BY PROSTAGLANDIN
    John Conrad; Fiscal Year: 1980
  4. METABOLISM OF THE TESTIS IN VITAMIN E DEFICIENCY
    Mary Carpenter; Fiscal Year: 1980
  5. EICOSANOIDS AND PREGNANT HUMAN MYOMETRIUM
    CH RAO; Fiscal Year: 1993
  6. ETHANOL CONSUMPTION AND PROSTAGLANDIN METABOLISM
    SAM PENNINGTON; Fiscal Year: 1980
  7. BRONCHIAL SENSITIVITY TO MEDIATORS
    Againdra Bewtra; Fiscal Year: 1980
  8. EFFECTS OF PROSTAGLANDINS ON MYOMETRIAL METABOLISM
    CLARISSA BEATTY; Fiscal Year: 1980
  9. ROLE OF EICOSANOIDS IN HEMOPHILIC ARTHROPATHY
    Marie Stuart; Fiscal Year: 1991
  10. CEREBROVASCULAR REACTIVITY--MODULATION BY HORMONES
    Jonathan Moss; Fiscal Year: 1991

Detail Information

Publications289 found, 100 shown here

  1. pmc Prostaglandin F(2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathway
    Kurt J Sales
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, The University of Edinburgh, Edinburgh, EH16 4TJ, UK
    Biochim Biophys Acta 1793:1917-28. 2009
    ....
  2. ncbi Isoprostanes: an overview and putative roles in pulmonary pathophysiology
    L J Janssen
    Asthma Research Group, Father Sean O Sullivan Research Center, St Joseph s Hospital, McMaster University, 50 Charlton Ave East, Hamilton, Ontario L8N 4A6, Canada
    Am J Physiol Lung Cell Mol Physiol 280:L1067-82. 2001
    ..In this review, I describe the chemistry, metabolism, and pharmacology of isoprostanes, with a particular emphasis on pulmonary cell types, and the possible roles of isoprostanes in pulmonary pathophysiology...
  3. ncbi Inherited human gp91phox deficiency is associated with impaired isoprostane formation and platelet dysfunction
    Pasquale Pignatelli
    Department of Internal Medicine and Medical Specialties, I Clinica Medica, University of Rome La Sapienza, Viale del Policlinico 155, Rome, Italy
    Arterioscler Thromb Vasc Biol 31:423-34. 2011
    ..We hypothesized that NADPH is implicated in isoprostane formation and platelet activation...
  4. ncbi Effect of prostaglandin F2 alpha on local luteotropic and angiogenic factors during induced functional luteolysis in the bovine corpus luteum
    Bajram Berisha
    Physiology Weihenstephan, Technical University Munich, Freising, Germany
    Biol Reprod 82:940-7. 2010
    ..The acute decrease of local luteotropic activity and acute changes of ANGPT2 and VEGFA suggest that modulation of vascular stability may be a key component in the cascade of events leading to functional luteolysis...
  5. ncbi Regulation of oxidative stress by glycaemic control: evidence for an independent inhibitory effect of insulin therapy
    L Monnier
    Laboratory of Human Nutrition and Atherogenesis, University Institute of Clinical Research, 34093 Montpellier Cedex 5, France
    Diabetologia 53:562-71. 2010
    ..We examined whether type of diabetes and/or insulin treatment can modulate the impact of sustained hyperglycaemia and glycaemic variability as activators of oxidative stress...
  6. ncbi Regulation of endometrial prostaglandin F(2alpha) synthesis during luteolysis and early pregnancy in cattle
    K Okuda
    Laboratory of Reproductive Endocrinology, Faculty of Agriculture, Okayama University, Japan
    Domest Anim Endocrinol 23:255-64. 2002
    ..The purpose of this review is to summarize our current understanding of the endocrine mechanisms that regulate the timing and pattern of uterine PGF(2alpha) secretion during the estrous cycle and early pregnancy...
  7. ncbi Requirement of cyclooxygenase-2 expression and prostaglandins for human prostate cancer cell invasion
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Clin Exp Metastasis 19:593-601. 2002
    ..Further, PGD2 may represent a weak inhibitor and counteracts the effect of PGE2 in the cell invasion...
  8. ncbi Prostaglandin F2alpha increases endothelial nitric oxide synthase in the periphery of the bovine corpus luteum: the possible regulation of blood flow at an early stage of luteolysis
    Koumei Shirasuna
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080 8555, Japan
    Reproduction 135:527-39. 2008
    ..Furthermore, the increased blood flow is mediated by NO, suggesting that the acute increase in peripheral blood flow to CL is one of the first physiological indicators of NO action in response to PGF(2)(alpha)...
  9. pmc Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin f(2α) impairs endothelial function in renovascular hypertensive rats
    Xiao Yu Tian
    Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong SAR, China
    Antioxid Redox Signal 16:363-73. 2012
    ..The current study investigated whether oxidative stress-dependent cyclooxygenase (COX)-2-derived prostaglandin F(2α) (PGF(2α)) impairs endothelial function in renal arteries of renovascular hypertensive rats (RHR)...
  10. ncbi Reduction in extracellular superoxide dismutase activity in African-American patients with hypertension
    Lichun Zhou
    Division of Cardiovascular Biology, Department of Biomedical Sciences, Meharry Medical College, Nashville, TN 37208, USA
    Free Radic Biol Med 41:1384-91. 2006
    ..Furthermore, the reduced EC-SOD activity might be at least partially responsible for the increased oxidative stress, as reflected by increased plasma nitrotyrosine and 8-isoprostane, in hypertensive subjects...
  11. ncbi Prostaglandin (PG) F(2alpha) receptor expression and signaling in human endometrium: role of PGF(2alpha) in epithelial cell proliferation
    Stuart A Milne
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, Edinburgh EH16 4SB, United Kingdom
    J Clin Endocrinol Metab 88:1825-32. 2003
    ....
  12. pmc Exhaled leukotrienes and prostaglandins in COPD
    P Montuschi
    Department of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy
    Thorax 58:585-8. 2003
    ....
  13. ncbi Differential expression of prostaglandin (PG) synthesis enzymes in conceptus during peri-implantation period and endometrial expression of carbonyl reductase/PG 9-ketoreductase in the pig
    Agnieszka Waclawik
    Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Tuwima 10, 10 747 Olsztyn, Poland
    J Endocrinol 194:499-510. 2007
    ..Moreover, high expression of conceptus PGHS-1, mPGES-1, PGFS, and CBR1 after initiation of implantation suggests their significant role in placentation...
  14. ncbi The synthesis and effects of prostaglandins on the ovary of the crab Oziotelphusa senex senex
    P Sreenivasula Reddy
    Department of Biotechnology, Sri Venkateswara University, 517 502, Tirupati, India
    Gen Comp Endocrinol 135:35-41. 2004
    ..In contrast, injection of prostaglandin D(2) did not affect ovarian growth. These results demonstrate the presence of prostaglandin biosynthetic system in ovary of the fresh water crabs...
  15. ncbi Treatment of unobserved oestrus in a dairy cattle herd with low oestrous detection rate up to 60 days post-partum
    L Mateus
    Laboratory of Reproduction, CIISA Faculdade de Medicina Veterinaria, Lisbon, Portugal
    Reprod Domest Anim 37:57-60. 2002
    ..Conception rate to AI up to 40 dpp was significantly reduced, compared with the period between 60 and 100 dpp but, mean days open were significantly improved in cows inseminated up to 60 dpp, compared with thereafter (p < 0.05)...
  16. ncbi Interferon-tau blocks the stimulatory effect of tumor necrosis factor-alpha on prostaglandin F2alpha synthesis by bovine endometrial stromal cells
    Kiyoshi Okuda
    Laboratory of Reproductive Endocrinology, Faculty of Agriculture, Okayama University, Okayama 700 8530, Japan
    Biol Reprod 70:191-7. 2004
    ....
  17. ncbi Invited review: Treatment of cows with an extended postpartum anestrous interval
    F M Rhodes
    Dexcel Limited, Private Bag 3221, Hamilton, New Zealand
    J Dairy Sci 86:1876-94. 2003
    ..However, responses to any treatment are variable and are related to those factors that influence duration of the PPI, such as body condition and parity...
  18. ncbi Partial antagonism of endothelin 1-induced vasoconstriction in the human choroid by topical unoprostone isopropyl
    Elzbieta Polska
    Department of Clinical Pharmacology, Allgemeines Krankenhaus Wien, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Arch Ophthalmol 120:348-52. 2002
    ..In patients with normal-tension glaucoma, ocular blood flow abnormalities may be associated with dysfunction of the endothelin 1 (ET-1) regulation system...
  19. ncbi Relationships between glucose excursion and the activation of oxidative stress in patients with newly diagnosed type 2 diabetes or impaired glucose regulation
    Fenping Zheng
    Department of Endocrinology, the Affiliated Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou 310016, China
    Endocrine 37:201-8. 2010
    ..01). We demonstrate that glucose excursions in subjects with IGR and T2DM trigger the activation of oxidative stress...
  20. ncbi Novel suppression mechanism operating in early phase of adipogenesis by positive feedback loop for enhancement of cyclooxygenase-2 expression through prostaglandin F2α receptor mediated activation of MEK/ERK-CREB cascade
    Toshiyuki Ueno
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, Japan
    FEBS J 278:2901-12. 2011
    ..Thus, PGF(2α) forms a positive feedback loop that coordinately suppresses the early phase of adipogenesis through the increased production of anti-adipogenic PGF(2α) and PGE(2) ...
  21. pmc Prostaglandin FP receptor inhibitor reduces ischemic brain damage and neurotoxicity
    Yun Tai Kim
    Korea Food Research Institute, Seongnam, Republic of Korea
    Neurobiol Dis 48:58-65. 2012
    ..These results indicate that the FP receptor is involved in cerebral ischemia-induced damage and could promote development of drugs for treatment of stroke and acute neurodegenerative disorders...
  22. ncbi Effect of intrauterine infusion of ceftiofur on uterine health and fertility in dairy cows
    K N Galvao
    Department of Clinical Sciences, Cornell University, Ithaca, NY 14853, USA
    J Dairy Sci 92:1532-42. 2009
    ..pyogenes, but did not affect the prevalence of subclinical endometritis or fertility of dairy cows already receiving PGF(2alpha)...
  23. ncbi Aggravation of bleomycin-induced pulmonary inflammation and fibrosis in mice lacking peroxiredoxin I
    Norihiro Kikuchi
    Department of Respiratory Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Am J Respir Cell Mol Biol 45:600-9. 2011
    ....
  24. pmc No relevant relationship between glucose variability and oxidative stress in well-regulated type 2 diabetes patients
    Sarah E Siegelaar
    Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Diabetes Sci Technol 5:86-92. 2011
    ..However, this relationship was not seen in type 1 diabetes. The purpose of this study is to reexamine the relation between glycemic variability and oxidative stress in a cohort of T2DM patients on oral medication...
  25. ncbi Depression and oxidative damage to lipids
    Sarah Yager
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
    Psychoneuroendocrinology 35:1356-62. 2010
    ..In conclusion, oxidative damage to lipid molecules may represent a common pathophysiological mechanism by which depressed individuals become more vulnerable to atherosclerosis and its clinical sequelae...
  26. ncbi Prostaglandin F(2alpha) suppresses early phase of adipogenesis, but is not associated with osteoblastogenesis in mouse mesenchymal stem cells
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Prostaglandins Other Lipid Mediat 93:52-9. 2010
    ..Therefore, PGF(2alpha) suppressed the progression of early phase adipogenesis after determination of the cell fate that causes MSC to differentiate into adipocytes...
  27. ncbi A positive feedback loop that regulates cyclooxygenase-2 expression and prostaglandin F2alpha synthesis via the F-series-prostanoid receptor and extracellular signal-regulated kinase 1/2 signaling pathway
    Henry N Jabbour
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, United Kingdom
    Endocrinology 146:4657-64. 2005
    ..Finally, we have shown that PGF2alpha could potentiate tumorigenesis in endometrial adenocarcinoma explants by inducing the expression of COX-2 mRNA...
  28. pmc Suppression of adipocyte differentiation by aldo-keto reductase 1B3 acting as prostaglandin F2alpha synthase
    Ko Fujimori
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    J Biol Chem 285:8880-6. 2010
    ..These results indicate that AKR1B3 acts as the PGFS in adipocytes and that AKR1B3-produced PGF(2alpha) suppressed adipocyte differentiation by acting through FP receptors...
  29. ncbi Matrix metalloproteinase (MMP)-2 and MMP-9 and their inhibitor, TIMP-1, in human term decidua and fetal membranes: the effect of prostaglandin F(2alpha) and indomethacin
    U Ulug
    Laboratory for Research in Reproductive Sciences, Department of Obstetrics and Gynecology, Ha'Emek Medical Center, Afula, Israel
    Mol Hum Reprod 7:1187-93. 2001
    ..Meanwhile the inhibition of PG production by indomethacin reduces total gelatinolytic activity in fetal membranes, possibly accounting for some of its labour-arresting property...
  30. ncbi Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microglia
    Ravi Shankar Akundi
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    Glia 51:199-208. 2005
    ..This detailed view of the intracellular signaling pathway in microglial activation and COX-2 expression opens a new therapeutic window in the search for new and more effective central anti-inflammatory agents...
  31. pmc F-prostanoid receptor alters adhesion, morphology and migration of endometrial adenocarcinoma cells
    K J Sales
    MRC Human Reproductive Sciences Unit, Medical Research Council, The Queen s Medical Research Institute, Edinburgh, UK
    Oncogene 27:2466-77. 2008
    ..These results reveal a mechanism by which prostanoids regulate cell movement, which may be relevant to pathologies of the endometrium...
  32. ncbi Withdrawal of ovarian steroids stimulates prostaglandin F2alpha production through nuclear factor-kappaB activation via oxygen radicals in human endometrial stromal cells: potential relevance to menstruation
    Norihiro Sugino
    Division of Obstetrics and Gynecology, Department of Reproductive, Pediatric and Infectious Science, Yamaguchi University School of Medicine, Ube, Japan
    J Reprod Dev 50:215-25. 2004
    ..In conclusion, EP-withdrawal stimulates COX-2 expression and PGF2alpha production through ROS-induced NF-kappaB activation, suggesting a possible mechanism for menstruation...
  33. ncbi Endothelins enhance prostaglandin (PGE(2) and PGF(2alpha)) biosynthesis and release by human luteal cells: evidence of a new paracrine/autocrine regulation of luteal function
    F Miceli
    Department of Obstetrics and Gynecology, , 00168 Rome, Italy
    J Clin Endocrinol Metab 86:811-7. 2001
    ....
  34. ncbi Enhanced lipid peroxidation and platelet activation in the early phase of type 1 diabetes mellitus: role of interleukin-6 and disease duration
    Giovanni Davi
    Center of Excellence on Aging and Department of Medicine, University of Chieti G d Annunzio Schools of Medicine and Pharmacy, Chieti, Italy
    Circulation 107:3199-203. 2003
    ..We also investigated the relationship between inflammatory markers and F2-isoprostane formation in this setting...
  35. ncbi Immune cells in the corpus luteum: friends or foes?
    J L Pate
    Department of Animal Sciences, Ohio State University, OARDC, Wooster, OH 44691, USA
    Reproduction 122:665-76. 2001
    ..Inhibition of immune cells in the corpus luteum during early pregnancy may be due to embryonic or uterine signals, or to maintenance of high progesterone concentrations within the luteal tissue...
  36. ncbi Involvement of pro-inflammatory cytokines, mediators of inflammation, and basic fibroblast growth factor in prostaglandin F2alpha-induced luteolysis in bovine corpus luteum
    T P Neuvians
    Department of Physiology, Technical University Munich, Weihenstephaner Berg 3, D 85350 Freising Weihenstephan, Germany
    Biol Reprod 70:473-80. 2004
    ..FGF-2 may participate in the suppression of cytokine-induced iNOS mRNA expression and in the prevention of an inflammatory reaction in the surrounding tissues...
  37. ncbi Novel cyclooxygenase-catalyzed bioactive prostaglandin F2alpha from physiology to new principles in inflammation
    Samar Basu
    Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Uppsala Science Park, Uppsala, Sweden
    Med Res Rev 27:435-68. 2007
    ..This review addresses multiple aspects of PGF2alpha in addition to its emerging role in physiology to inflammation...
  38. ncbi Formation of F-ring isoprostane-like compounds (F3-isoprostanes) in vivo from eicosapentaenoic acid
    Ling Gao
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 281:14092-9. 2006
    ..Further understanding of the biological consequences of F3-IsoP formation may provide valuable insights into the cardioprotective mechanism of EPA...
  39. ncbi Cyclooxygenase enzymes and prostaglandins in reproductive tract physiology and pathology
    K J Sales
    MRC Human Reproductive Sciences Unit, Center for Reproductive Biology, The University of Edinburgh Academic Center, 49 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SB, UK
    Prostaglandins Other Lipid Mediat 71:97-117. 2003
    ....
  40. ncbi A normotriglyceridemic, low HDL-cholesterol phenotype is characterised by elevated oxidative stress and HDL particles with attenuated antioxidative activity
    Anatol Kontush
    Dyslipoproteinemia and Atherosclerosis Research Unit U 551, National Institute for Health and Medical Research INSERM, Hopital de la Pitie, 83 Boulevard de l hopital, 75651 Paris Cedex 13, France
    Atherosclerosis 182:277-85. 2005
    ..It is indeterminate as to whether high cardiovascular risk in low HDL-C subjects occurs concomitantly with elevated oxidative stress and/or with biologically dysfunctional HDL particles...
  41. pmc Prostaglandin E2 and F2alpha activate the FP receptor and up-regulate cyclooxygenase-2 expression via the cyclic AMP response element
    Kurt J Sales
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Old Dalkeith Road, Edinburgh, United Kingdom
    Mol Cell Endocrinol 285:51-61. 2008
    ..These data indicate that PGE(2) and PGF(2alpha) biosynthesized locally within endometrial adenocarcinomas can regulate tumor cell function in an autocrine/paracrine manner via the FP receptor...
  42. ncbi 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy
    Giovanna E Carpagnano
    Institute of Respiratory Diseases, University of Bari, Bari, Italy
    Chest 124:1386-92. 2003
    ..Obstructive sleep apnea (OSA) is characterized by recurrent apnea during sleep that may compromise oxidative balance. Oxidative stress is increased in the blood and in the airways of OSA patients...
  43. ncbi Use of Ovsynch in dairy herds--differences between primiparous and multiparous cows
    Bernd Alois Tenhagen
    Clinic for Reproduction, Free University of Berlin, Section of Production Medicine and Quality Management, Koenigsweg 63, D 14163, Berlin, Germany
    Anim Reprod Sci 81:1-11. 2004
    ..8% versus 75.4%, P=0.003). However, the extent of the difference varied between trials. Results indicate that Ovsynch protocols are more effective in primiparous than in older cows...
  44. ncbi A calcium/calmodulin-dependent activation of ERK1/2 mediates JunD phosphorylation and induction of nur77 and 20alpha-hsd genes by prostaglandin F2alpha in ovarian cells
    Carlos O Stocco
    Department of Physiology and Biophysics, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Biol Chem 277:3293-302. 2002
    ..We conclude that activation of JunD through a calmodulim-dependent activation of ERK1/2 mediates nur77 induction by PGF(2alpha). Finally, we demonstrated that this molecular mechanism also mediates 20alpha-hsd induction...
  45. ncbi Effect of intraluteal injection of endothelin type A receptor antagonist on PGF2alpha-induced luteolysis in the cow
    Sho Watanabe
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Japan
    J Reprod Dev 52:551-9. 2006
    ..Thus, the present study suggests that ET-1 regulates structural luteolysis via ETR-A by controlling blood vessel contraction in the CL of the cow...
  46. ncbi Endothelin-1 mediates prostaglandin F(2alpha)-induced luteal regression in the ewe
    S T Hinckley
    Department of Animal Science, University of Connecticut, Storrs, Connecticut 06269-4040, USA
    Biol Reprod 64:1619-23. 2001
    ..These data complement and extend previously published reports in the bovine CL and are the strongest evidence presented to date in support of a role for ET-1 in PGF(2alpha)-mediated luteal function in domestic ruminants...
  47. ncbi Prostaglandin F2alpha differentially affects mRNA expression relating to angiogenesis, vasoactivation and prostaglandins in the early and mid corpus luteum in the cow
    Koumei Shirasuna
    Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan
    J Reprod Dev 56:428-36. 2010
    ..mature) but also the region (periphery vs. center) within the CL at 30 min after PGF(2alpha) injection in the cow...
  48. ncbi Hypertension increases the participation of vasoconstrictor prostanoids from cyclooxygenase-2 in phenylephrine responses
    Yolanda Alvarez
    Departamento de Farmacología y Terapéutica bDepartamento de Fisiología, Facultad de Medicina, Universidad Autonoma de Madrid, Spain
    J Hypertens 23:767-77. 2005
    ..The present study was designed to analyse whether hypertension alters the involvement of cyclooxygenase-2-derived mediators in phenylephrine-induced vasoconstrictor responses...
  49. ncbi Skeletal muscle PGF(2)(alpha) and PGE(2) in response to eccentric resistance exercise: influence of ibuprofen acetaminophen
    T A Trappe
    Nutrition, Metabolism, and Exercise Laboratory, Donald W Reynolds Center on Aging, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA
    J Clin Endocrinol Metab 86:5067-70. 2001
    ....
  50. ncbi The yin and yang of corpus luteum-derived endothelial cells: balancing life and death
    Rina Meidan
    Department of Animal Sciences, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Domest Anim Endocrinol 29:318-28. 2005
    ..e. c-fos and c-jun mRNA, further suggesting a mitogenic effect for this prostaglandin in LEC. These data imply that PGF2alpha may assume different and perhaps opposing roles depending on luteal microenvironment...
  51. ncbi Exercise restores coronary vascular function independent of myogenic tone or hyperglycemic status in db/db mice
    Farzad Moien-Afshari
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Physiol Heart Circ Physiol 295:H1470-80. 2008
    ..We conclude that the vascular benefits of moderate levels of exercise were independent of changes in myogenic tone or hyperglycemic status and primarily involved increased nitric oxide bioavailability in the coronary microcirculation...
  52. pmc Microglia are the major cellular source of inducible nitric oxide synthase during experimental herpes encephalitis
    Cristina P Marques
    Neuroimmunology Laboratory, Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Neurovirol 14:229-38. 2008
    ....
  53. ncbi A postgenomic integrated view of prostaglandins in reproduction: implications for other body systems
    M A Fortier
    Unité de Recherche en Ontogénie et Reproduction, Centre de Recherche du CHUQ CHUL, Quebec, Québec GIV4G2, Canada
    J Physiol Pharmacol 59:65-89. 2008
    ..We present here an integrated view of PG action based on observations in the female reproductive system, but with potential strategic implications for cardiovascular and metabolic complications...
  54. ncbi Correlation between two markers of inflammation, serum C-reactive protein and interleukin 6, and indices of oxidative stress in patients with high risk of cardiovascular disease
    Dora Il'yasova
    Duke Comprehensive Cancer Center, 2424 Erwin Rd, Hock Bldg, Ste 602, Box 2949, Durham, NC 27710, USA
    Biomarkers 13:41-51. 2008
    ..Urinary levels of F2-IsoP and serum levels of CRP represent appropriate biomarkers for future studies of inflammation and oxidative status in humans...
  55. ncbi Effect of repeated ACTH-stimulation on early embryonic development and hormonal profiles in sows
    P Razdan
    Department of Obstetrics and Gynaecology, Center for Reproductive Biology in Uppsala CRU, Swedish University of Agricultural Sciences, P O Box 7039, SE 750 07 Uppsala, Sweden
    Anim Reprod Sci 70:127-37. 2002
    ....
  56. ncbi NADPH oxidase is involved in prostaglandin F2alpha-induced hypertrophy of vascular smooth muscle cells: induction of NOX1 by PGF2alpha
    Masato Katsuyama
    Department of Pharmacology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Biol Chem 277:13438-42. 2002
    ..Taken together, these results suggest that hypertrophy of vascular smooth muscle cells caused by PGF(2alpha) is mediated by NOX1 induction and the resultant overproduction of O(2)(-) by NADPH oxidase...
  57. ncbi F2-isoprostane receptors on hepatic stellate cells
    Concetta Gardi
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Siena, Italy
    Lab Invest 88:124-31. 2008
    ..14+/-1.9 x 10(-6) M and K(i)=1.15+/-0.3 x 10(-9) M, respectively), suggesting the involvement of a modified form of isoprostane receptor, homologous to the classic thromboxane A2-binding site in F2-isoprostanes-evoked responses on HSC...
  58. ncbi Anti-apoptotic roles of prostaglandin E2 and F2alpha in bovine luteal steroidogenic cells
    Anom Bowolaksono
    Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700 8530, Japan
    Biol Reprod 79:310-7. 2008
    ..The overall results suggest that PGE2 and PGF2alpha locally play luteoprotective roles in bovine CL by suppressing apoptosis of LSCs...
  59. ncbi Effect of different doses of prostaglandin on the area of corpus luteum, the largest follicle and progesterone concentration in the dairy cow
    A Répási
    Kenézlõ Dózsa Agricultural Ltd, Kenézlõ, Hungary
    Reprod Domest Anim 38:423-8. 2003
    ..At the same time, the decrease in the percentage changes relative to the area of CL and to the concentrations of P4 were statistically significant in both treated groups...
  60. ncbi Prostaglandin F(2alpha) regulation of the bovine corpus luteum endothelin system during the early and midluteal phase
    M F Wright
    Department of Biology, West Virginia University, Morgantown, West Virginia 26506-6057, USA
    Biol Reprod 65:1710-7. 2001
    ..A practical application of this observation is that it may be possible to target the ET-1 gene as a way to manipulate the luteolytic action of PGF(2alpha)...
  61. ncbi Postprandial lipaemia does not affect resting haemodynamic responses but does influence cardiovascular reactivity to dynamic exercise
    Victoria G Rontoyanni
    Nutritional Sciences Division, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NH, UK
    Br J Nutr 104:863-71. 2010
    ..Postprandial lipaemia induced by a HFM does not affect cardiac output and/or SVR at rest, but it blunts the increase in BP during exercise...
  62. pmc Oxidative damage, platelet activation, and inflammation to predict mobility disability and mortality in older persons: results from the health aging and body composition study
    Matteo Cesari
    Institut du vieillissement, Universite de Toulouse, 37 Allees Jules Guesde, 31000 Toulouse, France
    J Gerontol A Biol Sci Med Sci 67:671-6. 2012
    ..The aim of the present study is to assess whether biomarkers representing these mechanisms predicted major adverse health-related events in older persons...
  63. ncbi Timing of prostaglandin F(2alpha) release episodes and oxytocin receptor development during luteolysis in the cow
    G E Mann
    University of Nottingham, School of Biosciences, Division of Animal Physiology, Sutton Bonington Campus, Loughborough LE12 5RD, UK
    Anim Reprod Sci 93:328-36. 2006
    ..Receptor concentrations then continued to increase reaching peak concentrations of 651+/-142 after luteolysis had been completed...
  64. ncbi Effect of climate on the response to three oestrous synchronisation techniques in lactating dairy cows
    M Alnimer
    Dipartimento di Scienze Zootecniche e Ispezione degli Alimenti, Universita degli Studi di Napoli Federico II, Portici NA, Italy
    Anim Reprod Sci 71:157-68. 2002
    ....
  65. pmc An efficient sample preparation method for high-throughput analysis of 15(S)-8-iso-PGF2α in plasma and urine by enzyme immunoassay
    A Bielecki
    Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON K1A 0K9, Canada
    J Anal Toxicol 36:595-600. 2012
    ..8 ± 5.5 pg/mL and 2.9 ± 2.0 ng/mg creatinine, respectively. The robustness and analytical performance of this method makes it a promising tool for high-throughput screening of biological samples for 8-iso-PGF2α...
  66. ncbi A passage and storage system for isolated bovine endometrial epithelial and stromal cells
    Shuko Murakami
    Laboratory of Reproductive Endocrinology, Faculty of Agriculture, Okayama University, Japan
    J Reprod Dev 49:531-8. 2003
    ..05). These results suggest that stored cells could be used for studying the physiology of bovine endometrium in vitro until passage 1 in endometrial epithelial cells, and until passage 4 in stromal cells...
  67. ncbi Maturation-related variations in prostaglandin and fatty acid content of ovary in the kuruma prawn (Marsupenaeus japonicus)
    Daisuke Tahara
    Department of Marine Bioscience, Fukui Prefectural University, 1 1 Gakuen, Obama, Fukui, Japan
    Comp Biochem Physiol A Mol Integr Physiol 137:631-7. 2004
    ..01) and stage IV (PGE(2), P<0.01). These results suggest that ovarian PGs and arachidonic acid are deeply involved in ovarian maturation in kuruma prawns...
  68. ncbi Timed artificial insemination with estradiol cypionate or insemination at estrus in high-producing dairy cows
    R L A Cerri
    Veterinary Medicine Teaching and Research Center, University of California Davis, Tulare 93274, USA
    J Dairy Sci 87:3704-15. 2004
    ..Use of 1 mg of ECP to induce ovulation as part of a synchrony regimen improved reproduction at first postpartum insemination in dairy cows...
  69. ncbi Relative changes in mRNA expression of angiopoietins and receptors tie in bovine corpus luteum during estrous cycle and prostaglandin F2alpha-induced luteolysis: a possible mechanism for the initiation of luteal regression
    Jun Tanaka
    Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan
    J Reprod Dev 50:619-26. 2004
    ..Overall, results suggest that decrease of ANPT-1 mRNA is a basic mechanism of vascular remodeling in CL. In addition, ANPT-2 might play a role in regulation of P4 secretion in CL during luteolysis...
  70. ncbi Changes in prostaglandin secretion by the regressing bovine corpus luteum
    Kanako Hayashi
    Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080 8555, Japan
    Prostaglandins Other Lipid Mediat 70:339-49. 2003
    ..Thus, luteal secretion of PGs may be involved in the local mechanism for structural rather than functional luteolysis...
  71. ncbi Influence of different isoforms of recombinant trophoblastic interferons on prostaglandin production in cultured bovine endometrial cells
    Julie Parent
    Département d Ontogénie et Reproduction, Centre de Recherches du Centre Hospitalier Universitaire de Québec CHUL, Universite Laval, Ste Foy, Quebec, Canada G1V 4G2
    Biol Reprod 68:1035-43. 2003
    ..The results showing two distinct responses to IFN-tau depending on its concentration and/or isoform and the absence of correlation with antiviral activity suggest that complex transduction mechanisms are involved...
  72. ncbi Associations of plasma 8-isoprostane levels with the presence and extent of coronary stenosis in patients with coronary artery disease
    Bin Wang
    Department of Pharmacology, Institute of Clinical Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Najing, 210029 Jiangsu Province, China
    Atherosclerosis 184:425-30. 2006
    ..47 and P=0.001). The results suggested that 8-iso-PGF(2alpha) is associated with the presence of CAD in patients undergoing coronary angiography and is also related to the extent of coronary stenosis in Chinese population...
  73. ncbi Efficacy of PGF(2alpha) to synchronize estrus in water buffalo cows (Bubalus bubalis) is dependent upon plasma progesterone concentration, corpus luteum size and ovarian follicular status before treatment
    L F C Brito
    Faculty of Veterinary Medicine, Federal University of Uberlandia, Uberlandia MG, Brazil
    Anim Reprod Sci 73:23-35. 2002
    ..After detection of a corpus luteum (CL) by rectal palpation, cows were treated (im) with dinoprost (12.5, 25 or 50mg) or D(+) cloprostenol (75, 150 or 300 microg) in a total of 66 treatments...
  74. ncbi Effect of topical unoprostone isopropyl on optic nerve head circulation in controls and in normal-tension glaucoma patients
    Itaru Kimura
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Jpn J Ophthalmol 49:287-93. 2005
    ..To evaluate the effect of unoprostone isopropyl on microcirculation in the optic nerve head (ONH) of controls and patients with normal-tension glaucoma (NTG)...
  75. ncbi Effect of induction of late embryonic mortality on plasma profiles of pregnancy associated glycoprotein 1 in heifers
    O Szenci
    Szent Istvan University, Faculty of Veterinary Science, Clinic for Large Animals, H 2225 Ullo Dóra major, Hungary
    Vet J 165:307-13. 2003
    ..The results of this study indicate that a PAG1 assay may provide an alternative method to ultrasonography for determining LEM in the cow...
  76. ncbi Cloning and expression of a cDNA for the human prostanoid FP receptor
    M Abramovitz
    Department of Molecular Biology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
    J Biol Chem 269:2632-6. 1994
    ..In summary, we have cloned the human prostanoid FP receptor which is functionally coupled to the Ca2+ signalling pathway...
  77. pmc Bacteriological and cytological findings during the late puerperal period after two different treatments of retained placenta followed by acute puerperal metritis
    Julia Jeremejeva
    Department of Therapy, Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Tartu, Estonia
    Acta Vet Scand 52:41. 2010
    ..No differences were found in body temperature on day 14 PP, presence of bacteriological infections and disappearance of uterine inflammatory signs diagnosed by cytological examination between experimental groups...
  78. pmc Effects of a single administration of prostaglandin F2alpha, or a combination of prostaglandin F2alpha and prostaglandin E2, or placebo on fertility variables in dairy cows 3-5 weeks post partum, a randomized, double-blind clinical trial
    Gaby Hirsbrunner
    Clinic for Ruminants, Vetsuisse Faculty of the University of Berne, Bremgartenstrasse 109a, 3012 Berne, Switzerland
    Reprod Biol Endocrinol 4:65. 2006
    ..In commercial dairy farming, the benefit of a single post partum combined prostaglandin treatment should be demonstrated...
  79. ncbi A mouse model of angiotensin II slow pressor response: role of oxidative stress
    Noritaka Kawada
    Center for Hypertension and Renal Disease Research, Georgetown University Medical Center, 3800 Reservoir Road NE, Washington, DC 20007 2197, USA
    J Am Soc Nephrol 13:2860-8. 2002
    ..There is evidence of increased oxidative stress that is implicated in the increase in the BP and RVR in this model...
  80. ncbi Uterine contractility in response to different prostaglandins: results from extracorporeally perfused non-pregnant swine uteri
    Andreas Mueller
    Department of Obstetrics and Gynaecology, Erlangen University Hospital, Erlangen, Germany
    Hum Reprod 21:2000-5. 2006
    ..The goal of this study was to assess dynamic changes in uterine contractility and peristalsis in response to PGs in comparison with the effects of oxytocin administration...
  81. ncbi Effect of repeated administration of PGF2alpha in the early post partum period on the prevalence of clinical endometritis and probability of pregnancy at first insemination in lactating dairy cows
    K E M Hendricks
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610 0136, USA
    Theriogenology 65:1454-64. 2006
    ....
  82. ncbi Nitric oxide induces apoptosis in bovine luteal cells
    Anna J Korzekwa
    Department of Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland
    J Reprod Dev 52:353-61. 2006
    ..The overall results suggest that NO is a luteolytic factor that plays a crucial role in regulation of the estrous cycle in structural luteolysis by inducing apoptosis of luteal cells in cattle...
  83. ncbi Endometritis treatment with a PGF2alpha analog does not improve reproductive performance in a large dairy herd in Argentina
    Miguel Eduardo Mejía
    Laboratorio de regulación Hipofisaria, Instituto de Biologia y Medicina Experimental CONICET, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
    Theriogenology 63:1266-76. 2005
    ..Furthermore, the standard treatment for endometritis (treatment with a prostaglandin analog and withholding insemination until clinical signs abated) impaired reproductive performance and increased costs...
  84. ncbi Nitric oxide (NO) inhibits prostaglandin E2 9-ketoreductase (9-KPR) activity in human fetal membranes
    M G Farina
    Center for Pharmacological and Botanical Studies CEFYBO, CONICET, Laboratory of Physiopathology of Pregnancy and Labor, Paraguay 2155, C1121ABG Buenos Aires, Argentina
    Prostaglandins Other Lipid Mediat 79:260-70. 2006
    ..Our data suggests that exogenous NO inhibits 9-KPR activity in HFM, thus modulating the synthesis of important labor mediators as PGF(2alpha)...
  85. ncbi Cooperative expression of monocyte chemoattractant protein 1 within the bovine corpus luteum: evidence of immune cell-endothelial cell interactions in a coculture system
    Amy R Liptak
    Department of Animal and Nutritional Sciences, University of New Hampshire, Durham, New Hampshire 03824, USA
    Biol Reprod 72:1169-76. 2005
    ..Additionally, activated immune cells appear to produce a factor that impairs progesterone production by luteal steroidogenic cells...
  86. ncbi Participation of intraluteal progesterone and prostaglandin F2 alpha in LH-induced luteolysis in pregnant rat
    C O Stocco
    , CRICYT CONICET, Mendoza, Argentina
    J Endocrinol 156:253-9. 1998
    ..Thus, the early decline in 3 beta-HSD activity and the consequent fall in intraluteal P4 content, may trigger the synthesis of PGs and thereafter the increase in luteal 20 alpha-HSD activity to establish luteolysis...
  87. ncbi Intraluteal regulation of prostaglandin F2 alpha-induced prostaglandin biosynthesis in pseudopregnant rabbits
    M Zerani
    Dipartimento di Biologia Molecolare, Cellulare e Animale, Universita di Camerino, via F Camerini 1, Camerino, Italy
    Reproduction 133:1005-16. 2007
    ....
  88. ncbi Coordinate regulation of prostaglandin metabolism for induction of parturition in mice
    Sandra K Winchester
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Endocrinology 143:2593-8. 2002
    ....
  89. ncbi Uterine involution and fertility of holstein cows subsequent to early postpartum PGF2alpha treatment for acute puerperal metritis
    P Melendez
    College of Veterinary Medicine, University of Florida, Gainesville 32610, USA
    J Dairy Sci 87:3238-46. 2004
    ....
  90. ncbi Long-term effect of topically applied isopropyl unoprostone on microcirculation in the human ocular fundus
    Yukiko Makimoto
    Department of Ophthalmology, Osaka Medical College, Osaka, Japan
    Jpn J Ophthalmol 46:31-5. 2002
    ..To investigate the long-term effect of 0.12% isopropyl unoprostone (Rescula) on microcirculation in the human ocular fundus...
  91. ncbi Gonadotropins and cytokines affect luteal function through control of apoptosis in human luteinized granulosa cells
    H Matsubara
    Department of Obstetrics and Gynecology, Nagoya City University Medical School, Nagoya, Japan
    J Clin Endocrinol Metab 85:1620-6. 2000
    ..Our results also suggest that Fas, Fas ligand, p53, and Bax may play roles in this apoptosis controlled by hCG, TGFbeta1, and M-CSF...
  92. ncbi Intraluteal prostaglandin biosynthesis and signaling are selectively directed towards PGF2alpha during luteolysis but towards PGE2 during the establishment of pregnancy in sheep
    Jehoon Lee
    Reproductive Endocrinology and Cell Signaling Laboratory, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, USA
    Biol Reprod 87:97. 2012
    ....
  93. ncbi Comparison of oxidative stress markers in type 2 diabetes: basal bolus therapy versus twice daily premixed insulin analogs
    Masaki Sakamoto
    Diabetes Center, Kitasato Institute Hospital, Tokyo
    Intern Med 49:355-9. 2010
    ..However, glycemic fluctuations that lead to oxidative stress may be associated with the risk of diabetic complications. Therefore, in this study, we compared oxidative stress markers between MIX therapy and BB therapy...
  94. ncbi Insulin therapy has a complex relationship with measure of oxidative stress in type 2 diabetes: a case for further study
    Louis Monnier
    Laboratory of Human Nutrition and Atherogenesis, University Institute of Clinical Research, Montpellier Cedex 5, France
    Diabetes Metab Res Rev 27:348-53. 2011
    ....
  95. ncbi Reactive oxygen species stimulate prostaglandin F2 alpha production in human endometrial stromal cells in vitro
    N Sugino
    Department of Obstetrics and Gynecology, Yamaguchi University School of Medicine, Minamikogushi 1 1 1, Ube 755 8505, Japan
    Hum Reprod 16:1797-801. 2001
    ..The present study was undertaken to investigate the effect of reactive oxygen species on prostaglandin F2 alpha (PGF2 alpha) production by human endometrial stromal cells (ESC)...
  96. ncbi The effect of hemolysis on plasma oxidation and nitration in patients with sickle cell disease
    Alphan Kupesiz
    Department of Pediatric Hematology, Akdeniz University Medical School, Antalya, Turkey
    Free Radic Res 46:883-90. 2012
    ..The obtained data shows that increased haemolysis in SCD increases plasma protein oxidation and nitration...
  97. ncbi Acute changes in circulating concentrations of progesterone and nitric oxide and partial pressure of oxygen during prostaglandin F2alpha-induced luteolysis in cattle
    Tomas Javier Acosta
    Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan
    J Reprod Dev 55:149-55. 2009
    ....
  98. ncbi Role of nitric oxide in the regulation of superoxide dismutase and prostaglandin F(2alpha) production in bovine luteal endothelial cells
    Seunghyung Lee
    Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan
    J Reprod Dev 56:454-9. 2010
    ....
  99. ncbi Effect of dietary polyunsaturated fatty acids on uterine prostaglandin synthesis in the cow
    Z Cheng
    Reproduction and Development Group, Department of Veterinary Basic Sciences, Royal Veterinary College, Boltons Park, Hawkshead Road, Potters Bar, Hertfordshire EN6 1NB, UK
    J Endocrinol 171:463-73. 2001
    ..These data suggest that a high n-6 diet reduces the endometrial capacity to produce PGs and may therefore have implications for the control of luteolysis and other PG-mediated events such as ovulation...
  100. ncbi Arachidonic acid release and prostaglandin F(2alpha) formation induced by anandamide and capsaicin in PC12 cells
    Akiyoshi Someya
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263 8522, Japan
    Eur J Pharmacol 450:131-9. 2002
    ..These findings suggest that anandamide and capsaicin stimulated arachidonic acid metabolism in cannabinoid receptors- and vanilloid VR(1) receptor-independent manner in PC12 cells. The possible mechanisms are also discussed...
  101. ncbi Prostaglandin F2alpha stimulates tyrosine phosphorylation and mitogen-activated protein kinase in osteoblastic MC3T3-E1 cells via protein kinase C activation
    Y Hakeda
    Department of Oral Anatomy, Meikai University School of Dentistry, Sakado, Saitama, Japan
    Endocrinology 138:1821-8. 1997
    ..Thus, the action of PGF2alpha on osteoblastic MC3T3-E1 cells appears to involve a single receptor that uses diverse interacting signal transduction systems...

Research Grants62

  1. PG-INDUCED REDUCTION OF INTRAOCULAR PRESSURE
    Carl Camras; Fiscal Year: 1993
    ..Argon laser treatment to the peripheral iris and Nd:YAG laser treatment to the trabecular mesh-work will be performed in cats to determine whether they also result in reduction of IOP mediated by PGs...
  2. OVULATION--STUDIES USING IN VITRO PERFUSED OVARIES
    Edward Wallach; Fiscal Year: 1992
    ..An in depth knowledge of the periovulatory interval (follicle rupture, oocyte maturation, and corpus luteum formation) is critical for developing new methods for improving reproductive performance and for achieving fertility control...
  3. STRETCH CHANGES IN THE RABBIT CERVIX BY PROSTAGLANDIN
    John Conrad; Fiscal Year: 1980
    ..Strips of the cervix will be stretched and the stress-strain curves evaluated by linear regression analysis to obtain a single parameter, the stretch modulus, and this will be used to compare the various drugs and treatments. ..
  4. METABOLISM OF THE TESTIS IN VITAMIN E DEFICIENCY
    Mary Carpenter; Fiscal Year: 1980
    ..Since prostaglandins have regulatory effects on cells in mitosis and on differentiation, the relationship between arachidonic acid, vitamin E, and prostaglandins in testis needs to be evaluated...
  5. EICOSANOIDS AND PREGNANT HUMAN MYOMETRIUM
    CH RAO; Fiscal Year: 1993
    ..The delay or prevention of preterm labor can potentially save a large segment of the health care dollars now used for intensive neonatal care...
  6. ETHANOL CONSUMPTION AND PROSTAGLANDIN METABOLISM
    SAM PENNINGTON; Fiscal Year: 1980
    ..Such studies will provide a starting point for the treatment of pathophysiology related to changes in prostaglandin metabolism as the result of ethanol consumption...
  7. BRONCHIAL SENSITIVITY TO MEDIATORS
    Againdra Bewtra; Fiscal Year: 1980
    ..The effect of various antagonizing agents will be established by administering them by aerosol prior to the inhalation challenge on a subsequent day...
  8. EFFECTS OF PROSTAGLANDINS ON MYOMETRIAL METABOLISM
    CLARISSA BEATTY; Fiscal Year: 1980
    ..Plasma E2 and P levels in these animals will be correlated with changes in metabolism. ..
  9. ROLE OF EICOSANOIDS IN HEMOPHILIC ARTHROPATHY
    Marie Stuart; Fiscal Year: 1991
    ..The project could lead to the use of inhibitors of cyclooxygenase, lipoxygenase, or leukotriene biosynthesis in an attempt to modulate the animal (and ultimately) hemophilic-induced arthropathy...
  10. CEREBROVASCULAR REACTIVITY--MODULATION BY HORMONES
    Jonathan Moss; Fiscal Year: 1991
    ..An understanding of the pathophysiology of sex hormone modulation of vasospasm could identify patients at special risk and suggest new therapeutic options...
  11. Phthalate Exposure and Pregnancy Outcome
    T Peter Stein; Fiscal Year: 2010
    ..The findings will have ramifications for public health, for the packaging trade and for the chemical industry. ..
  12. SELENIUM AND LUNG CANCER RISK
    Henry Thompson; Fiscal Year: 2004
    ..In addition, this work has the potential to provide new biomarkers with which to assess lung cancer risk and its modulation. ..
  13. MECHANISMS REGULATING UTERINE MORPHOGENESIS
    Thomas Spencer; Fiscal Year: 2004
    ....
  14. TLR's, Nitric Oxide and Chronic Lung Disease
    William Truog; Fiscal Year: 2005
    ..Its results may also open up intriguing pathways for treatments aimed at selective diminution of pulmonary inflammation. ..
  15. Ovary Intact Murine Model for Menopause
    Patricia Hoyer; Fiscal Year: 2007
    ..Characterization of the VCD-treated mouse will, therefore, make a profound contribution to the study of menopause-related pathologies and, therefore, to women's health. ..
  16. Cell Signaling in the Kidney
    VICTOR SCHUSTER; Fiscal Year: 2007
    ....
  17. Agonist Activity at G Protein Coupled Receptors
    FRED EHLERT; Fiscal Year: 2008
    ..Our proposed investigation of Galpha15 and Galpha16 is highly significant with regard to the widespread use of this G protein as a transducer for both orphan and known receptors. ..
  18. SIGNALING PATHWAYS IN CHEMICAL INDUCED OVOTOXICITY
    Patricia B Hoyer; Fiscal Year: 2010
    ..This will lead to an appreciation of the global impact of the environment on the reproductive life span in women. ..
  19. Genetic Regulation of Postnatal Uterine Morphogenesis and Function
    Thomas Spencer; Fiscal Year: 2008
    ..This research will help determine important genes for reproduction and help to design clinical therapies to prevent, identify and treat reproductive problems in women. [unreadable] [unreadable] [unreadable]..
  20. Role of Prostaglandins & Phospholipase A in melanocytes
    Glynis Scott; Fiscal Year: 2009
    ..We hypothesize that PG and phospholipases stimulate HM dendricity, MS transfer &pigmentation through different mechanisms that act synergistically to modulate cutaneous pigmentation following UVR. ..
  21. Mechanism of Renal Prostaglandin Transport
    Victor L Schuster; Fiscal Year: 2010
    ..As such, the work offers the potential to open up new approaches to the management of pain, fever, inflammation, hypertension, and a variety of other medical conditions. ..
  22. Role of Regulated CIC CI Channels in CI Secretion in CF
    John Cuppoletti; Fiscal Year: 2006
    ..2 K channel in CF. This will also be studied in terms of CI transport, Na transport, CLCA2 function, inflammation and bacterial susceptibility. ..
  23. ENVIRONMENTAL EPOXIDES--MECHANISMS OF OVOTOXICITY
    Patricia Hoyer; Fiscal Year: 2002
    ..The results of these studies will provide greater insight as to the impact of exposure to ovotoxic environmental chemicals on reproductive health in women. ..
  24. Progestogen Inhibition of Ovarian Cancer Cell Metastasis
    William Murdoch; Fiscal Year: 2003
    ....
  25. CHLORIDE CHANNELS AND GASTRIC ACID SECRETION
    John Cuppoletti; Fiscal Year: 2003
    ..These studies strive to address the fundamental questions regarding the molecules and mechanisms involved in regulated HCl secretion. ..
  26. ENHANCED TISSUE REGENERATION OF OROFACIAL MUSCLES
    GRACE PAVLATH; Fiscal Year: 2002
    ....
  27. Frontiers in Myogenesis
    GRACE PAVLATH; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  28. Calcineurin in Prostaglandin Mediated Muscle Growth
    GRACE PAVLATH; Fiscal Year: 2005
    ..abstract_text> ..
  29. Cellular and molecular regulation of muscle stem cells
    GRACE PAVLATH; Fiscal Year: 2009
    ..Studies of Sca-1 may lead to new strategies for manipulating myogenic stem cells in disease, repair and aging and define novel therapeutic targets for enhancing muscle growth. ..
  30. MAJOR HISTOCOMPATIBILITY MOLECULES IN LUTEAL FUNCTION
    JOY PATE; Fiscal Year: 2005
    ....
  31. Regulation of Myoblast Fusion
    Grace K Pavlath; Fiscal Year: 2010
    ..Studies of the MR may lead to new strategies for manipulating myoblasts in disease, repair and aging and define novel therapeutic targets for enhancing muscle growth. ..
  32. THROMBOXANE A2 RECEPTORS IN HEALTH AND DISEASE
    Perry Halushka; Fiscal Year: 2001
    ....
  33. Analgesics and resistance training in older individuals
    Todd Trappe; Fiscal Year: 2008
    ..This investigation will provide important information for clinicians and older individuals with regard to expected benefits from physical activity during periods of analgesic and anti-inflammatory based therapy. ..
  34. OXIDATION OF MACROMOLECULES IN SPINAL CORD INJURY
    Danxia Liu; Fiscal Year: 2001
    ..This will directly test whether free radicals damage neurons by inducing oxidation of major cell components and will provide strategies for therapy. ..
  35. BIOCHEMICAL PATHWAYS OF 12-HETE AND 12-KETE METABOLISM
    Joshua Rokach; Fiscal Year: 2010
    ..It is likely that these eosinophils are responsible for late phase asthma or inflammatory asthma. We plan to develop agents that will stop the infiltration of these cells into the lung and prevent inflammatory asthma. ..
  36. GLAUCOMA SURGICAL OUTCOMES STUDY
    Henry Jampel; Fiscal Year: 2001
    ..The results of the study may allow physicians to reduce the morbidity of glaucoma surgery by altering their indications for surgery, surgical technique, and postoperative follow-up. ..
  37. Targeting Histone Deacetylation: A Tool for Chemopevention of Esophageal Cancer
    Laura Kresty; Fiscal Year: 2008
    ..goal of identifying and translating efficacious preventive agents into the clinic for evaluation in high risk human cohorts, including patients with long standing Barrett's esophagus or [unreadable] [unreadable] [unreadable]..
  38. CaP, crystal responsible for idiopathic nephrolithasis
    Saeed Khan; Fiscal Year: 2008
    ..Type density and size must conform to limits and specifications provided in the PHS 398Instructions. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  39. Hypertonic Modulation of Inflammation following Injury
    Eileen M Bulger; Fiscal Year: 2010
    ..The results of these studies will provide valuable information to determine the ultimate therapeutic use of the resuscitation strategy. ..
  40. REGULATION OF LUTEAL FUNCTION
    Geula Gibori; Fiscal Year: 2009
    ....
  41. Pediatric Severe Asthma: Role of Oxidant Stress and Alveolar Macrophage Function
    Anne Fitzpatrick; Fiscal Year: 2009
    ..This proposal will lay the foundation for further studies, and the mechanisms identified may ultimately be targeted in future interventional trials. ..
  42. Leukocyte C2GIcNAcT-I in atherosclerosis
    Yuqing Huo; Fiscal Year: 2009
    ..These studies will have significant implications for the inhibition of leukocyte C2GlcNAcT-l in the prevention and treatment of atherosclerosis and its complications. ..
  43. OCULAR HYPERTENSION TREATMENT STUDY (OHTS)
    Robert Weinreb; Fiscal Year: 2008
    ....
  44. EICOSANOIDS IN FOCAL SEGMENTAL GLOMERULOSCLEROSIS
    Ellen McCarthy; Fiscal Year: 2002
    ..Additionally, they may lead to a better understanding of the general mechanism by which proteinuria develops and thus point to interventions that may alleviate or prevent proteinuria in FSGS and in other glomerular diseases. ..
  45. INTERVENTIONS TO PREVENT NOISE INDUCED HEARING LOSS
    JOSEF MILLER; Fiscal Year: 2007
    ..We will also determine if reduced blood flow potentiates NIHL, in vivo. These studies will define new interventions and synergies at sites along the apoptotic pathway to optimize the prevention of NIHL. ..
  46. Effects of FSGS factor on arachidonic acid metabolism
    Ellen McCarthy; Fiscal Year: 2003
    ..These studies will provide insight into the pathophysiology of proteinuria in patients with recurrent FSGS and may lead to novel treatment strategies in these patients. ..
  47. PROSTAGLANDINS IN PRIMATE OVULATORY FOLLICLES
    DIANE DUFFY; Fiscal Year: 2003
    ..This may provide insight into the mechanisms leading to infertility (e.g., leuteinized unruptured follice syndrome) and support the developoment of PG synthesis inhibitors of PG synthesis inhibitors for use as contraceptives. ..
  48. BIOCHEMICAL PATHWAYS OF 12 HETE AND 12 KETE METABOLISM
    Joshua Rokach; Fiscal Year: 2004
    ..In addition, we will investigate reductive pathways responsible for the conversion of 12-oxo-ETE to the potent proinflammatory agent 12-HETrE (12R-hydroxy-5Z,8Z,14Z-eicosatrienoic acid). ..
  49. Prostease-activated receptor-2 in uterine contractility
    Yuri Vedernikov; Fiscal Year: 2004
    ..The potential benefits of these studies include a better understanding of the mechanisms modulating uterine contractility, thereby improving our ability to control it clinically. ..
  50. Vasopressin Effects on Social Communication
    RICHMOND THOMPSON; Fiscal Year: 2004
    ..abstract_text> ..
  51. Mechansim of tea catechin's inhibition of angiogenesis
    Mohsen Meydani; Fiscal Year: 2003
    ..abstract_text> ..
  52. Robotics Extraction System/HPLC for Shared Resource Lab
    Mark Chappell; Fiscal Year: 2005
    ..abstract_text> ..
  53. SMOKING AND ATHEROSCLEROSIS: MECHANISMS AND MODULATION
    Anne Burke; Fiscal Year: 2005
    ..We expect that smoking reduction and cessation and the administration of antioxidants and aspirin will improve these parameters towards the levels of healthy volunteers and that the effects will be additive. ..
  54. MOLECULAR MECHANISMS OF ESTROGEN INDUCED CARCINOGENESIS
    HARI BHAT; Fiscal Year: 2002
    ....
  55. OXIDATIVE STRESS, ANTIOXIDANT STATUS & PREGNANCY OUTCOME
    Theresa Scholl; Fiscal Year: 2005
    ....
  56. IGF-I SIGNALING IN GRANULOSA CELLS
    John Davis; Fiscal Year: 2004
    ..This new insight may uncover mechanistic defects that underlay disorders of folliculogenesis, premature ovarian failure and disorders such as polycystic ovarian syndrome. ..
  57. Diagnostic and Natural History Markers in ALS
    Hiroshi Mitsumoto; Fiscal Year: 2003
    ..abstract_text> ..
  58. Upgrade of mass spectrometer facility
    Michael Thomas; Fiscal Year: 2003
    ..The new mass spectrometer will provide 1) a significant increase in detection sensitivity, 2) higher resolution, 3) greater accuracy of mass measurement, 4) increased reliability, and 5) compatibility with new generations of software. ..
  59. ADAPTATION OF SENESCENT MUSCLE TO EXERCISE TRAINING
    Todd Trappe; Fiscal Year: 2002
    ....
  60. Estrogen, ACE2 and Salt-Sensitivity
    Mark Chappell; Fiscal Year: 2008
    ..Lewis strain. ..