leukotriene e4

Summary

Summary: A biologically active principle of SRS-A that is formed from LEUKOTRIENE D4 via a peptidase reaction that removes the glycine residue. The biological actions of LTE4 are similar to LTC4 and LTD4. (From Dictionary of Prostaglandins and Related Compounds, 1990)

Top Publications

  1. pmc The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications
    K Frank Austen
    Department of Medicine, Harvard Medical School, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Allergy Clin Immunol 124:406-14; quiz 415-6. 2009
  2. pmc Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor
    Sailaja Paruchuri
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 206:2543-55. 2009
  3. pmc Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors
    Akiko Maekawa
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:16695-700. 2008
  4. doi Polymorphisms of cyclo-oxygenases and 5-lipo-oxygenase-activating protein are associated with chronic spontaneous urticaria and urinary leukotriene E4
    Gabriele Di Lorenzo
    Dipartimento di Medicina Clinica e delle Patologie Emergenti, Universita di Palermo, Palermo, Italy
    Eur J Dermatol 21:47-52. 2011
  5. ncbi Leukotriene E4 and granulocytic infiltration into asthmatic airways
    L A Laitinen
    Department of Pulmonary Medicine, Helsinki University Central Hospital, Finland
    Lancet 341:989-90. 1993
  6. ncbi Urinary leukotriene E4 concentrations increase after aspirin challenge in aspirin-sensitive asthmatic subjects
    P E Christie
    Department of Allergy and Allied Respiratory Disorders, UMDS, Guy s Hospital, London, UK
    Am Rev Respir Dis 143:1025-9. 1991
  7. ncbi An examination of the influence of the epithelium on contractile responses to peptidoleukotrienes and blockade by ICI 204,219 in isolated guinea pig trachea and human intralobar airways
    C K Buckner
    Department of Pharmacology, ICI Pharmaceuticals Group, ICI Americas Inc, Wilmington, Delaware
    J Pharmacol Exp Ther 252:77-85. 1990
  8. ncbi Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics
    M Kumlin
    Department of Physiological Chemistry, Karolinska Institutet, Stockholm, Sweden
    Am Rev Respir Dis 146:96-103. 1992
  9. ncbi Urinary leukotriene E4 in bronchial asthma
    C M Smith
    Dept of Allergy and Allied Respiratory Disorders, Guy s Hospital, London, UK
    Eur Respir J 5:693-9. 1992
  10. ncbi The relative responsiveness to inhaled leukotriene E4, methacholine and histamine in normal and asthmatic subjects
    S P O'Hickey
    Department of Medicine, United Medical School, Guy s Hospital, London, U K
    Eur Respir J 1:913-7. 1988

Detail Information

Publications194 found, 100 shown here

  1. pmc The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications
    K Frank Austen
    Department of Medicine, Harvard Medical School, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Allergy Clin Immunol 124:406-14; quiz 415-6. 2009
    ..These findings prompt a renewed focus on LTE(4) receptors as therapeutic targets that are not currently addressed by available receptor antagonists...
  2. pmc Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor
    Sailaja Paruchuri
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 206:2543-55. 2009
    ..Thus, the P2Y12 receptor is required for proinflammatory actions of the stable abundant mediator LTE4 and is a novel potential therapeutic target for asthma...
  3. pmc Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors
    Akiko Maekawa
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:16695-700. 2008
    ..Our findings establish the existence of a third receptor, CysLT(E)R, that responds preferentially to LTE(4), the most abundant cys-LT in biologic fluids, and thus reveal a new target for therapeutic intervention...
  4. doi Polymorphisms of cyclo-oxygenases and 5-lipo-oxygenase-activating protein are associated with chronic spontaneous urticaria and urinary leukotriene E4
    Gabriele Di Lorenzo
    Dipartimento di Medicina Clinica e delle Patologie Emergenti, Universita di Palermo, Palermo, Italy
    Eur J Dermatol 21:47-52. 2011
    ..We also examined the levels of urinary leukotriene E4 (LTE4) before and after challenge with ASA...
  5. ncbi Leukotriene E4 and granulocytic infiltration into asthmatic airways
    L A Laitinen
    Department of Pulmonary Medicine, Helsinki University Central Hospital, Finland
    Lancet 341:989-90. 1993
    ..Since LTE4 recruits granulocytes, the potential of antisulphidopeptide leukotriene drugs as anti-inflammatory and "steroid-sparing" agents should be tested...
  6. ncbi Urinary leukotriene E4 concentrations increase after aspirin challenge in aspirin-sensitive asthmatic subjects
    P E Christie
    Department of Allergy and Allied Respiratory Disorders, UMDS, Guy s Hospital, London, UK
    Am Rev Respir Dis 143:1025-9. 1991
    Urinary leukotriene E4 (LTE4) concentrations have been measured in six asthmatic patients with aspirin sensitivity and in five asthmatic subjects tolerant of aspirin, before and after provocation with aspirin or placebo...
  7. ncbi An examination of the influence of the epithelium on contractile responses to peptidoleukotrienes and blockade by ICI 204,219 in isolated guinea pig trachea and human intralobar airways
    C K Buckner
    Department of Pharmacology, ICI Pharmaceuticals Group, ICI Americas Inc, Wilmington, Delaware
    J Pharmacol Exp Ther 252:77-85. 1990
    ..These data suggest that contractile responses of guinea pig trachea to LTE4 are modulated by LTE4-induced release of 5-lipoxygenase product(s) only when the epithelium is present.(ABSTRACT TRUNCATED AT 250 WORDS)..
  8. ncbi Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics
    M Kumlin
    Department of Physiological Chemistry, Karolinska Institutet, Stockholm, Sweden
    Am Rev Respir Dis 146:96-103. 1992
    ..abstract truncated at 250 words)..
  9. ncbi Urinary leukotriene E4 in bronchial asthma
    C M Smith
    Dept of Allergy and Allied Respiratory Disorders, Guy s Hospital, London, UK
    Eur Respir J 5:693-9. 1992
    b>Leukotriene E4 (LTE4) is excreted into the urine in a relatively constant proportion of 4-7% when either leukotriene C4 (LTC4) or LTE4 is intravenously infused, regardless of the magnitude of the infused dose...
  10. ncbi The relative responsiveness to inhaled leukotriene E4, methacholine and histamine in normal and asthmatic subjects
    S P O'Hickey
    Department of Medicine, United Medical School, Guy s Hospital, London, U K
    Eur Respir J 1:913-7. 1988
    The relative bronchoconstricting potencies of leukotriene E4 (LTE4) methacholine and histamine have been compared in asthmatic and normal subjects...
  11. pmc Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma
    Nathan Rabinovitch
    Department of Pediatrics, National Jewish Health and the University of Colorado Denver School of Medicine, Denver, Colo 80206, USA
    J Allergy Clin Immunol 126:545-51.e1-4. 2010
    ..A subset of children with asthma respond better to leukotriene receptor antagonists than to inhaled corticosteroids. Information is needed to identify children with these preferential responses...
  12. ncbi Pediatric biomarkers in asthma: exhaled nitric oxide, sputum eosinophils and leukotriene E4
    Shaila Gogate
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Curr Opin Allergy Clin Immunol 8:154-7. 2008
    ..Three biomarkers, fractional exhaled nitric oxide, sputum eosinophils and leukotriene E4 in the urine and exhaled breath condensate, have been heavily investigated.
  13. pmc Leukotriene E4 activates human Th2 cells for exaggerated proinflammatory cytokine production in response to prostaglandin D2
    Luzheng Xue
    Oxford Biomedical Research Centre, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
    J Immunol 188:694-702. 2012
    ..These findings reveal that cysLTs, in particular LTE(4), have a significant proinflammatory impact on T cells and demonstrate their effects on Th2 cells are mediated by a montelukast-sensitive receptor...
  14. ncbi Increased urinary leukotriene E4 excretion in obstructive sleep apnea: effects of obesity and hypoxia
    Françoise Stanke-Labesque
    Institut National de la Sante et de la Recherche Medicale, Grenoble, France
    J Allergy Clin Immunol 124:364-70, 370.e1-2. 2009
    ..However, the respective contribution of intermittent hypoxia and confounders, such as obesity, is still debated...
  15. ncbi Elevated urinary leukotriene E4 excretion in patients with ARDS and severe burns
    J Y Westcott
    CVP Research Lab, University of Colorado Health Sciences Center, Denver 80262
    Prostaglandins Leukot Essent Fatty Acids 43:151-8. 1991
    ..In certain situations, urinary LTE4 levels may be useful as a marker of the degree of inflammation...
  16. pmc Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells
    Sailaja Paruchuri
    Department of Medicine, Division of Rheumatology, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 283:16477-87. 2008
    ..This LTE(4)-selective receptor-mediated pathway may explain the unique physiologic responses of human airways to LTE(4) in vivo...
  17. ncbi Leukotriene E4 elimination and metabolism in normal human subjects
    A Sala
    Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver 80206
    J Biol Chem 265:21771-8. 1990
    ..The major metabolites of LTE4 might be useful in assessing in vivo production of sulfidopeptide leukotrienes in humans...
  18. ncbi Urinary leukotriene E4
    Nathan Rabinovitch
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Immunol Allergy Clin North Am 27:651-64; vii. 2007
    Measurement of urinary leukotriene E4 (LTE4) is a sensitive and noninvasive method of assaying total body cysteinyl leukotriene production and changes in cysteinyl leukotriene levels in specific microenvironments, such as the airway...
  19. doi Urinary cysteinyl leukotriene E4 significantly increases during pain in children and adults with sickle cell disease
    Joshua J Field
    Division of Hematology, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Hematol 84:231-3. 2009
    Baseline level of the cysteinyl leukotriene (CysLT), leukotriene E4 (LTE4), is associated with an increased pain rate in children and adults with sickle cell disease (SCD)...
  20. pmc Elevated urinary leukotriene E4 levels are associated with hospitalization for pain in children with sickle cell disease
    Jeanine E Jennings
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Hematol 83:640-3. 2008
    ..52 episodes per 100 patient-years, P = 0.038). LTE(4) levels are elevated in children with SCD when compared with controls. LTE(4) levels are associated with an increased rate of hospitalizations for pain...
  21. doi Exposure to tobacco smoke increases leukotriene E4-related albuterol usage and response to montelukast
    Nathan Rabinovitch
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colo 80206, USA
    J Allergy Clin Immunol 121:1365-71. 2008
    ..Cysteinyl leukotrienes (CysLTs) are important mediators of asthma in children. Predictors of susceptibility to CysLT effects have not been developed...
  22. ncbi Urinary leukotriene E4 levels after allergen and exercise challenge in bronchial asthma
    C M Smith
    Department of Allergy and Allied Respiratory Disorders, Guy s Hospital, London, United Kingdom
    Am Rev Respir Dis 144:1411-3. 1991
    Urinary leukotriene E4 (LTE4) concentrations were measured in six asthmatic subjects after treadmill exercise, and in five asthmatic subjects after allergen challenge...
  23. ncbi Urinary leukotriene E4 and 9 alpha, 11 beta-prostaglandin F concentrations in mild, moderate and severe asthma, and in healthy subjects
    N L A Misso
    Cooperative Research Centre for Asthma, The University of Western Australia, Perth, Australia
    Clin Exp Allergy 34:624-31. 2004
    ..Measurement of urinary metabolites of these eicosanoids may be useful for monitoring asthma patients. However, the influence of asthma phenotype and severity on basal urinary excretion of these metabolites is unknown...
  24. ncbi Clinical features of asthmatic patients with increased urinary leukotriene E4 excretion (hyperleukotrienuria): Involvement of chronic hyperplastic rhinosinusitis with nasal polyposis
    Noritaka Higashi
    Clinical Research Center, National Sagamihara Hospital, Kanagawa, Japan
    J Allergy Clin Immunol 113:277-83. 2004
    The urinary leukotriene E4 (U-LTE4) concentration is significantly increased in patients with aspirin-intolerant asthma (AIA)...
  25. ncbi Effects of a leukotriene receptor antagonist on exhaled leukotriene E4 and prostanoids in children with asthma
    Paolo Montuschi
    Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Largo F Vito 1, 00168 Rome, Italy
    J Allergy Clin Immunol 118:347-53. 2006
    ..The effects of leukotriene receptor antagonists (LTRAs) on exhaled leukotriene and prostanoids in children with asthma are unknown...
  26. ncbi Manganese enhances peroxynitrite and leukotriene E4 formation in bovine aortic endothelial cells exposed to arsenic
    Melisa Bunderson
    Department of Biomedical and Pharmaceutical Sciences and Center for Environmental Health Sciences, The University of Montana, Missoula, 59812, USA
    Cardiovasc Toxicol 6:15-23. 2006
    ..Arsenic exposure also increases leukotriene E4 (LTE4) formation in both the mice and BAECs, an effect that is partially reversed by the addition of Nomega-..
  27. ncbi Differential effects of fluticasone propionate on allergen-evoked bronchoconstriction and increased urinary leukotriene E4 excretion
    R Wellings
    Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, United Kingdom
    Am Rev Respir Dis 147:1472-6. 1993
    Allergen challenge is associated with an increased excretion of urinary leukotriene E4. The source of this increase is unknown, although the lack of effect of inhaled beta-agonists and sodium cromoglycate suggests that airway mast cells ..
  28. ncbi Characterization of the human cysteinyl leukotriene 2 receptor
    C E Heise
    Department of Pharmacology, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
    J Biol Chem 275:30531-6. 2000
    ....
  29. ncbi Leukotriene E4 release in cold urticaria
    N H Maltby
    Department of Clinical Pharmacology, Royal Postgraduate Medical School, London
    Clin Exp Allergy 19:33-6. 1989
    ..b>Leukotriene E4 (LTE4; a stable metabolic product of LTC4 and LTD4) and histamine were measured in the blood draining the site ..
  30. ncbi Increased leukotriene E4 in the exhaled breath condensate of children with mild asthma
    Atsushi Shibata
    Department of Pediatrics, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Chest 130:1718-22. 2006
    ..The aim of this study was to examine the relationship between EBC cys-LTs (LTE(4)) levels and bronchial hyperreactivity in children with mild asthma in order to evaluate the clinical utility of measuring EBC cys-LTs levels...
  31. ncbi Urinary leukotriene E4 levels during early and late asthmatic responses
    P J Manning
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 86:211-20. 1990
    ..68; p = 0.001). No significant increase in urinary LTE4 levels occurred during the LAR. These results suggest that the LTE4 precursors, LTC4 and LTD4, are important bronchoconstrictor mediators causing EARs after allergen inhalation...
  32. doi Urinary leukotriene E4 excretion: a biomarker of inflammatory bowel disease activity
    Françoise Stanke-Labesque
    Laboratory of Pharmacology, Grenoble University Hospital, Grenoble, France
    Inflamm Bowel Dis 14:769-74. 2008
    ....
  33. pmc The mechanism of LTE4-induced histamine hyperresponsiveness in guinea-pig tracheal and human bronchial smooth muscle, in vitro
    C A Jacques
    Department of Allergy and Allied Respiratory Disorders, Guy s Hospital, London
    Br J Pharmacol 104:859-66. 1991
    1. Preincubation of guinea-pig tracheal smooth muscle with leukotriene E4 (LTE4) in vitro increased its subsequent responsiveness to histamine. 2...
  34. ncbi Urinary leukotriene E4 after lysine-aspirin inhalation in asthmatic subjects
    P E Christie
    Swiss Institute for Asthma and Allergy Research, Davos
    Am Rev Respir Dis 146:1531-4. 1992
    The FEV1 and urinary leukotriene E4 (LTE4) concentrations were determined in six aspirin-sensitive and six non-aspirin-sensitive asthmatic subjects before and after inhalation challenge with lysine-aspirin or placebo solution...
  35. ncbi Recovery of leukotriene E4 from the urine of patients with airway obstruction
    J M Drazen
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Am Rev Respir Dis 146:104-8. 1992
    The urinary excretion of leukotriene E4 (LTE4) was measured in subjects presenting for emergency treatment of airway obstruction...
  36. ncbi Inhaled leukotriene E(4), but not leukotriene D(4), increased airway inflammatory cells in subjects with atopic asthma
    G M Gauvreau
    Asthma Research Group, St. Joseph's Healthcare, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 164:1495-500. 2001
    ..These results suggest cysteinyl leukotrienes play a role in eosinophil migration into the airways in allergic asthma, and for the same degree of bronchoconstriction, inhaled LTE(4) causes more tissue and airway eosinophilia than LTD(4)...
  37. ncbi Increased levels of urinary leukotriene E4 in children with severe atopic eczema/dermatitis syndrome
    K Øymar
    Department of Pediatrics, Rogaland Central Hospital, Stavanger, Norway
    Allergy 60:86-9. 2005
    Leukotrienes are thought to play a role in the pathogenesis of atopic eczema/dermatitis syndrome (AEDS). Urinary leukotriene E4 (U-LTE4) is a marker of whole-body cysteinyl-leukotriene production.
  38. ncbi Effect of indomethacin on leukotriene4-induced histamine hyperresponsiveness in asthmatic subjects
    P E Christie
    Department of Allergy and Allied Respiratory Disorders, Guy s Hospital, London, England
    Am Rev Respir Dis 146:1506-10. 1992
    ..68 +/- 0.46, and this was significantly decreased compared with that on the placebo day (p = 0.02). This suggests that LTE4-induced enhanced responsiveness to histamine is mediated in part by cyclooxygenase pathway-derived products...
  39. doi Leukotriene E4: perspective on the forgotten mediator
    Tak H Lee
    MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, London, United Kingdom
    J Allergy Clin Immunol 124:417-21. 2009
    ..This has stimulated a search for additional LT receptors that would respond preferentially to LTE(4) stimulation...
  40. ncbi Direct injection method for quantitation of endogenous leukotriene E4 in human urine by liquid chromatography/electrospray ionization tandem mass spectrometry with a column-switching technique
    N Kishi
    Analytical Research Laboratories, Eisai Co Ltd, 5 1 3 Tokodai, Tsukuba, Ibaraki 300 2635, Japan
    Anal Sci 17:709-13. 2001
    ..mass spectrometry (LC/MS/MS) with a column-switching system was developed for quantitative determination of leukotriene E4 (LTE4) in human urine...
  41. ncbi Enhanced urinary excretion of leukotriene E4 in patients with mevalonate kinase deficiency
    E Mayatepek
    University Children s Hospital, Heidelberg, Germany
    J Pediatr 123:96-8. 1993
    ..A positive linear relationship between increased urinary excretion of mevalonate and LTE4 (n = 5) suggests that increased cysteinyl leukotriene synthesis is involved in the pathomechanisms of this disease...
  42. ncbi Identification of endogenous surrogate ligands for human P2Y12 receptors by in silico and in vitro methods
    Yosuke Nonaka
    Laboratory of Pharmcoinformatics, Department of Bioinformatics, Ritsumeikan University, Kusatsu, Shiga 525 8577, Japan
    Biochem Biophys Res Commun 337:281-8. 2005
    ..The analyses showed that the P2Y12, P2Y13, P2Y14, GPR87, CysLT-1, and CysLT-2 receptors formed a P2Y-related receptor subfamily with common sequence motifs in the transmembrane regions...
  43. ncbi Urinary leukotriene E4 after antigen challenge and in acute asthma and allergic rhinitis
    G W Taylor
    Department of Clinical Pharmacology, Royal Postgraduate Medical School, Hammersmith Hospital, London
    Lancet 1:584-8. 1989
    ..These studies provide evidence that leukotrienes are released in vivo in man after antigen challenge and in acute asthma...
  44. ncbi Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebo-controlled trial
    Sven Erik Dahlen
    Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Respir Crit Care Med 165:9-14. 2002
    ..Addition of a leukotriene receptor antagonist such as montelukast improves asthma in aspirin-intolerant patients over and above what can be achieved by glucocorticosteroids...
  45. ncbi Nasal blockage and urinary leukotriene E4 concentration in patients with seasonal allergic rhinitis
    N Higashi
    Clinical Research Center, National Sagamihara Hospital, Kanagawa, Japan
    Allergy 58:476-80. 2003
    ..However, there has been little experimental evidence that substantiates the relationship between nasal blockage severity and urinary leukotriene E4 (U-LTE4) concentration in patients with seasonal allergic rhinitis (SAR).
  46. pmc Increase in urinary leukotriene LTE4 levels in acute asthma: correlation with airflow limitation
    S A Green
    Merck Research Laboratories, Rahway, NJ, USA
    Thorax 59:100-4. 2004
    ..Activation of leukotriene pathways is accompanied by rises in detectable urinary levels of leukotriene E4 (LTE4)...
  47. ncbi [Urinary leukotriene E4 concentration in patients with bronchial asthma and intolerance of non-steroids anti-inflammatory drugs before and after oral aspirin challenge]
    Renata Rubinsztajn
    Katedra i Klinika Chorób Wewnetrznych Pneumonologii i Alergologii AM w Warszawie
    Pol Arch Med Wewn 110:849-54. 2003
    ..The aim of the study was estimated the urinary concentration of LTE4 in patients with bronchial asthma and intolerance of no steroids anti-inflammatory drugs...
  48. ncbi A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice
    Takahide Nagase
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Am J Physiol Lung Cell Mol Physiol 284:L720-6. 2003
    ..The current observations suggest that pharmacological intervention of cPLA(2) could be a novel therapeutic approach to acute lung injury caused by sepsis syndrome...
  49. ncbi Montelukast, a leukotriene receptor antagonist, in vernal keratoconjunctivitis associated with asthma
    Alessandro Lambiase
    Interdisciplinary Research Center, University Campus Bio Medico, Laboratory of Ophthalmology, Rome, Italy
    Arch Ophthalmol 121:615-20. 2003
    ..To evaluate the effects on signs and symptoms of a coexisting vernal keratoconjunctivitis in patients treated with oral montelukast sodium for asthma...
  50. ncbi Cysteinyl leukotriene receptors
    Jilly F Evans
    Department of Pharmacology, Merck Research Laboratories, Merck and Co, West Point, PA 19486, USA
    Prostaglandins Other Lipid Mediat 68:587-97. 2002
    The cysteinyl leukotrienes, leukotriene C4 (LTC4), leukotriene D4 (LTD4) and leukotriene E4 (LTE4), activate contractile and inflammatory processes via specific interaction with putative seven transmembrane-spanning receptors that couple ..
  51. ncbi Evidence of mast cell activation and leukotriene release after mannitol inhalation
    J D Brannan
    Dept of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, Australia
    Eur Respir J 22:491-6. 2003
    ..Increased bronchial responsiveness to the released mediators could explain the exclusive bronchoconstriction in asthmatic subjects...
  52. ncbi Effects of cysteinyl leukotrienes in small human bronchus and antagonist activity of montelukast and its metabolites
    H Mechiche
    Laboratory of Pharmacology, EA 2070, Faculty of Medicine, Reims, France
    Clin Exp Allergy 33:887-94. 2003
    ..Montelukast (MK), a specific CysLT1 receptor antagonist, is metabolized in two main hydroxylated metabolites (termed M5 and M6, respectively)...
  53. ncbi The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjects
    Fausto Braccioni
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, and the Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 110:96-101. 2002
    ..However, the effect of cysLTs on peripheral blood and bone marrow eosinophil pro-genitor cells in allergic subjects is not known...
  54. ncbi [Leukotrienes as inflammation mediators]
    Grzegorz Woszczek
    Katedra i Zakład Immunologii Klinicznej Uniwersytetu Medycznego w Łodzi
    Postepy Hig Med Dosw 57:593-610. 2003
    ..Several studies have shown that leukotrienes may play a significant role in pathomechanisms of inflammatory diseases of human airways, skin, digestive tract and heart...
  55. ncbi Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils
    Christianne Bandeira-Melo
    Division of Allergy and Inflammation, Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
    J Allergy Clin Immunol 109:975-9. 2002
    ..Eosinophils contain preformed stores of IL-4 within their cytoplasmic granules, but physiologic stimuli to release IL-4 from eosinophils are not yet defined...
  56. ncbi Protection against exercise-induced bronchoconstriction by montelukast in aspirin-sensitive and aspirin-tolerant patients with asthma
    L Mastalerz
    Department of Medicine, Jagiellonian University School of Medicine, Cracow, Poland
    Clin Exp Allergy 32:1360-5. 2002
    ..Aspirin-induced asthma (AIA) is characterized by overproduction of cysteinyl-leukotrienes...
  57. ncbi Cysteinyl leukotrienes in the bile of patients with obstructive jaundice
    Masahito Uemura
    Third Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara 634 8521, Japan
    J Gastroenterol 37:821-30. 2002
    ..To explore the clinical significance of biliary cysteinyl LTs, we determined their concentration changes in bile during treatment in patients with obstructive jaundice...
  58. ncbi Pranlukast inhibits NF-kappa B activation in human monocytes/macrophages and T cells
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, Yamaguchi and ONO Pharmaceutical Co Ltd, Osaka, Japan
    Clin Exp Allergy 33:802-7. 2003
    ..Pranlukast inhibits contraction of the tracheal muscle, and thereby antagonizes the binding of LTC4, LTD4 and LTE4. However, the action of pranlukast on monocytes/macrophages and T cells is unknown...
  59. ncbi Temporal profiles of cerebrospinal fluid leukotrienes, brain edema and inflammatory response following experimental brain injury
    Martin U Schuhmann
    Department of Neurosurgery, Hannover Medical School, Hannover, Germany
    Neurol Res 25:481-91. 2003
    ..The second leukotriene peak at 7 days is likely to follow a different pathway and might be related to a production in macrophages or activated glia...
  60. ncbi Concentrations of cysteinyl leukotrienes in urine and bronchoalveolar lavage fluid of cats with experimentally induced asthma
    Carol R Norris
    Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616 8734, USA
    Am J Vet Res 64:1449-53. 2003
    ..To evaluate changes in cysteinyl leukotriene (LT) concentrations in urine and bronchoalveolar lavage fluid (BALF) in cats with experimentally induced asthma...
  61. ncbi Evaluation of montelukast in 8 to 14 year old children with mild persistent asthma and compared with inhaled corticosteroids
    O Karaman
    Professor in Pediatric Allergy, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey
    Allergol Immunopathol (Madr) 32:21-7. 2004
    ..To determine the clinical effectiveness, tolerability and reliability of montelukast and to compare this drug with inhaled corticosteroids...
  62. ncbi Urinary 3-bromotyrosine and 3-chlorotyrosine concentrations in asthmatic patients: lack of increase in 3-bromotyrosine concentration in urine and plasma proteins in aspirin-induced asthma after intravenous aspirin challenge
    H Mita
    Clinical Research Center, National Sagamihara Hospital, Sagamihara, Kanagawa, Japan
    Clin Exp Allergy 34:931-8. 2004
    ..Eosinophil peroxidase and myeloperoxidase halogenate tyrosine residues in plasma proteins and generate 3-bromotyrosine (BY) and 3-chlorotyrosine (CY), respectively...
  63. ncbi Bronchial responsiveness to leukotriene D4 is resistant to inhaled fluticasone propionate
    Pär Gyllfors
    Division of Respiratory Medicine, Department of Medicine, Karolinska University Hospital Solna, Sweden
    J Allergy Clin Immunol 118:78-83. 2006
    ..Although the synthesis of leukotrienes is not affected by corticosteroid treatment, the influence of corticosteroids on the leukotriene pathway remains unresolved...
  64. ncbi Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends
    Valerie Capra
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Med Res Rev 27:469-527. 2007
    ....
  65. ncbi A novel method for preserving human lungs using a super-cooling system
    Masayoshi Abe
    Department of Pharmacology, School of Medicine, Fukuoka University, Fukuoka, Japan
    Ann Thorac Surg 82:1085-8. 2006
    ..To ensure the suitable preservation of isolated lungs, a super-cooling system was used to cool water to temperatures as low as -5 degrees C without freezing...
  66. ncbi Invited commentary
    Charles Hoopes
    Surgery Transplantation, University of California San Francisco, 350 Parnassus Ave, Suite 150, San Francisco, CA94143
    Ann Thorac Surg 82:1088-9. 2006
  67. ncbi Urine leukotriene E4 levels are associated with decreased pulmonary function in children with persistent airway obstruction
    Nathan Rabinovitch
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 118:635-40. 2006
    ..Use of leukotriene receptor antagonists improves disease control in children and adults with asthma. However, the relationship between cysteinyl leukotriene levels and indices of daily asthma control has not been studied directly...
  68. ncbi Quantification of leukotriene B4 glucuronide in human urine
    Haruhisa Mita
    Clinical Research Center, Sagamihara National Hospital, 18 1 Sakuradai, Sagamihara, Kanagawa 228 8522, Japan
    Prostaglandins Other Lipid Mediat 83:42-9. 2007
    ..Urinary leukotriene E4 and leukotriene B4 glucuronide concentrations in 13 normal healthy adults were 94...
  69. ncbi Effects of supportive treatment such as antioxidant or leukotriene receptor antagonist drugs on inflammatory and respiratory parameters in asthma patients
    T Tug
    Department of Chest, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey
    Clin Pharmacol Ther 81:371-6. 2007
    ..The serum levels before and after treatment of eosinophilic cationic protein (ECP), leukotriene E4 (LTE(4)), and malondialdehyde (MDA) were determined...
  70. ncbi [Leukotrienes: potential therapeutic targets in cardiovascular diseases]
    Magnus Bäck
    INSERM unité 698, CHU Xavier Bichat, 16 rue Henri Huchard, 75018 Paris
    Bull Acad Natl Med 190:1511-8; discussion 1518-21. 2006
    ..Further experimental and clinical studies are needed to determine the potential of therapeutic strategies targeting the leukotriene pathway in cardiovascular disease...
  71. ncbi Urinary LTE4 is higher after nasal provocation test with L-ASA in bronchial than in only nasal responders
    C Micheletto
    Lung Dept, Orlandi General Hospital, Bussolengo Verona, Italy
    Eur Ann Allergy Clin Immunol 39:162-6. 2007
    ....
  72. ncbi Omalizumab (Xolair) in children with seasonal allergic rhinitis: leukotriene release as a potential in vitro parameter to monitor therapeutic effects
    Matthias Volkmar Kopp
    University Children s Hospital, Freiburg, Germany
    Pediatr Allergy Immunol 18:523-7. 2007
    ..These results strongly suggest that the observed effects of decreased SLT release after omalizumab treatment were attributable to the treatment with omalizumab, rather than to SIT therapy...
  73. ncbi Evaluation and interference of serum and skin lesion levels of leukotrienes in patients with eczema
    Zhong Hua
    Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
    Prostaglandins Leukot Essent Fatty Acids 75:51-5. 2006
    ..05). Mizolastine significantly reduced serum LTB4 and IFN-gamma levels as well as skin lesion LTB4, LTC4, LTE4 concentrations. LTs are involved in the pathogenesis of eczema. Mizolastine clearly reduces LTs levels in skin lesion...
  74. ncbi Changes in urinary LTE4 and nasal functions following nasal provocation test with ASA in ASA-tolerant and -intolerant asthmatics
    Claudio Micheletto
    Lung Department, Orlandi Hospital, Via Ospedale 2, 37012 Bussolengo, VR, Italy
    Respir Med 100:2144-50. 2006
    ....
  75. ncbi Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma
    Hans Erik Claesson
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, and Orexo AB, Uppsala, Sweden
    FEBS J 275:4222-34. 2008
    ..Furthermore, the discovery of the high 15-lipoxygenase-1 activity in L1236 cells demonstrates that this cell line comprises a useful model system to study the chemical and biological roles of 15-lipoxygenase-1...
  76. pmc Urinary leukotriene LTE4 levels in non-responders to antileukotriene therapy
    D K C Lee
    Thorax 59:727; author reply 727. 2004
  77. ncbi Increase in urinary leukotriene B4 glucuronide concentration in patients with aspirin-intolerant asthma after intravenous aspirin challenge
    H Mita
    Clinical Research Center, National Sagamihara Hospital, Kanagawa, Japan
    Clin Exp Allergy 34:1262-9. 2004
    Aspirin challenge of aspirin-intolerant asthma (AIA) patients causes a significant increase in leukotriene E4 (LTE4) concentration in urine. However, knowledge on leukotriene B4 (LTB4) generation in patients with AIA is insufficient...
  78. ncbi Leukotriene E(4)-induced persistent eosinophilia and airway obstruction are reversed by zafirlukast in patients with asthma
    Annika Laitinen
    Institute of Biomedicine, Department of Anatomy, University of Helsinki, Helsinki, Finland
    J Allergy Clin Immunol 115:259-65. 2005
    ..We have shown that inhalation of leukotriene (LT) E 4 contributes to specific recruitment of eosinophils to the airway mucosa in patients with asthma at the time of maximal decrease in airway-specific conductance...
  79. ncbi Antigen specific quantification of sulfidoleukotrienes in patients allergic to Betalactam antibiotics
    C García-Avilés
    Departamento de Alergología e Inmunología Clínica, Clinica Universitaria de Navarra, Pamplona, Spain
    J Investig Allergol Clin Immunol 15:37-45. 2005
    ..This can be detected by means of the CAST assay. We assessed the positivity criteria and the reliability of antigen-specific sulfidoleukotriene production (CAST) in the in vitro diagnosis of betalactam (BL) allergic patients...
  80. ncbi [Leukotriene (B4, C4, D4, E4)]
    Satoshi Kitamura
    Minami Tochigi Hospital
    Nihon Rinsho 63:28-33. 2005
  81. ncbi Cysteinyl leukotrienes induce monocyte chemoattractant protein 1 in human monocytes/macrophages
    T Ichiyama
    Department of Pediatrics, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Clin Exp Allergy 35:1214-9. 2005
    ..Monocytes/macrophages have a cysteinyl leukotriene 1 (CysLT1) receptor, but its function is poorly understood. Objective To elucidate the biological function of the CysLT1 receptor of human monocytes/macrophages...
  82. ncbi A patient with neurological symptoms and abnormal leukotriene metabolism: a new defect in leukotriene biosynthesis
    Ertan Mayatepek
    Department of General Pediatrics, University Children s Hospital, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Ann Neurol 58:968-70. 2005
    ..These data suggest membrane-bound dipeptidase deficiency, a new defect in leukotriene biosynthesis on the step of LTE(4) synthesis, as underlying defect...
  83. ncbi Treatment of asthma with antileukotrienes: first line or last resort therapy?
    Sven Erik Dahlen
    Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Eur J Pharmacol 533:40-56. 2006
    ..Further research needs and new areas for leukotriene involvement in respiratory diseases are also discussed...
  84. ncbi Aspirin induced asthma (AIA) with nasal polyps has the highest basal LTE4 excretion: a study vs AIA without polyps, mild topic asthma, and normal controls
    C Micheletto
    Lung Dept, Bussolengo Gen Hospital, Verona, Italy
    Eur Ann Allergy Clin Immunol 38:20-3. 2006
    ..Urinary leukotriene E4 concentration (LTE4), that reflects the whole body production of cysteinil-leukotrienes, is particularly ..
  85. ncbi A novel polymorphism, E254K, in the 5-lipoxygenase gene associated with bronchial asthma
    Chunying Bai
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu 501 1193, Japan
    Int J Mol Med 21:139-44. 2008
    ..Thus, our results suggest that E254K in the 5-LO might be associated with BA...
  86. ncbi Enhanced prostaglandin E2 secretion in sputum from asthmatic patients after zafirlukast therapy
    J J Tsai
    Section of Allergy and Clinical Immunology, Cathay General Hospital, 280, Section 4, Jen-Ai Road, Taipei, Taiwan
    J Formos Med Assoc 100:241-3. 2001
    ..before and after therapy and concentrations of eosinophil cationic protein (ECP), prostaglandin E2 (PGE2), and leukotriene E4 (LTE4) were measured. RESULTS: A significant improvement in PEFR was found after zafirlukast therapy (p = 0...
  87. ncbi Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patients
    Yasushi Obase
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Chest 121:143-50. 2002
    ..Leukotrienes (LTs) are important in asthma, and LT modifiers modulate antigen-induced asthma. Overproduction of LT by suppression of cyclooxygenase activity is involved in patients with aspirin-intolerant asthma (AIA)...
  88. ncbi [The relationship between eosinophils, activated T lymphocyte, leukotreine and the exercise-induced asthma]
    Y Guo
    Department of Respiratory Medicine, Beijing Hospital, Beijing 100730, China
    Zhonghua Jie He He Hu Xi Za Zhi 24:360-4. 2001
    ..CONCLUSIONS: Hyperventilation during exercise may not be the cause leading to EIA, neither did the activation of T lymphocytes, IL-4 and IL-5 gene expression nor ECP. Leukotriene may play an important role in the pathogenesis of EIA...
  89. ncbi [Studies on the experimental allergic rhinitis induced by Japanese cedar pollen--role of cysteinyl leukotrienes in nasal allergic symptoms]
    Nobuaki Mizutani
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Yakugaku Zasshi 123:1-8. 2003
    ..The results presented in this study further suggest that our model is a good representative of human allergic rhinitis and offer evidence that CysLTs are chemical mediators mainly responsible for allergic nasal symptoms...
  90. ncbi Antiallergic effect of ardisiaquinone A, a potent 5-lipoxygenase inhibitor
    N Fukuishi
    Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan
    Phytomedicine 8:460-4. 2001
    ....
  91. ncbi Receptor preferences of cysteinyl-leukotrienes in the guinea pig lung parenchyma
    Kiyoto Sakata
    Experimental Asthma and Allergy Research, Institute of Environmental Medicine, Karolinska Institutet, 171 77, Stockholm, Sweden
    Eur J Pharmacol 436:119-26. 2002
    ..These results suggest that leukotriene E(4) solely activates a CysLT(1) receptor, and that the CysLT(1) receptor antagonist-resistant contraction to leukotriene D(4) and C(4) is mediated via another CysLT receptor...
  92. ncbi Possible involvement of mast-cell activation in aspirin provocation of aspirin-induced asthma
    H Mita
    Clinical Research Center, National Sagamihara Hospital, Japan
    Allergy 56:1061-7. 2001
    ..METHODS: Urinary concentrations of leukotriene E4 (LTE4), 11-dehydrothromboxane B2, 9alpha,11beta-prostaglandin F2, and Ntau-methylhistamine were measured ..
  93. pmc Exhaled leukotrienes and prostaglandins in COPD
    P Montuschi
    Department of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy
    Thorax 58:585-8. 2003
    ....
  94. ncbi Leukotrienes in patients with clinically active multiple sclerosis
    I S Neu
    Department of Neurology, Municipal Hospital, Academic Teaching, Hospital of Tübingen University, Sindelfingen, Germany
    Acta Neurol Scand 105:63-6. 2002
    ..Studies of LTs in the cerebrospinal fluid (CSF) revealed different results mainly because of analytical difficulties...
  95. ncbi Studies of receptors and modulatory mechanisms in functional responses to cysteinyl-leukotrienes in smooth muscle
    Magnus Bäck
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol Scand Suppl 648:1-55. 2002
    ..Moreover, the interconversion between LTC4 and LTD4 and the metabolism into LTE4 may represent a major modulatory mechanism in the guinea-pig trachea by deciding which CysLT receptor is activated by the cysteinyl-leukotrienes...
  96. ncbi SCF-induced airway hyperreactivity is dependent on leukotriene production
    S H Oliveira
    Department of Pathology, University of Michigan Medical School, 13012 Catherine, Ann Arbor, MI 48109-0602, USA
    Am J Physiol Lung Cell Mol Physiol 280:L1242-9. 2001
    ..Altogether, these studies indicate that SCF-induced airway hyperreactivity is dependent upon leukotriene-mediated pathways...
  97. pmc Role of cysteinyl leukotrienes in adenosine 5'-monophosphate induced bronchoconstriction in asthma
    S Rorke
    Division of Respiratory Cell and Molecular Biology, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK
    Thorax 57:323-7. 2002
    ..We hypothesised that adenosine induced bronchoconstriction in asthmatic patients may be blocked by pretreatment with the orally active selective cysteinyl leukotriene-1 (CysLT(1)) receptor antagonist, montelukast...
  98. ncbi [Study on relationship between leukotrienes and exercise-induced asthma]
    Tieying Sun
    Beijing Hospital, Beijing 100730, China
    Zhonghua Yi Xue Za Zhi 82:54-6. 2002
    ..To explore the relationship between leukotriene (LT) and exercise-induced asthma...
  99. ncbi Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs
    Ryoichi Suzuki
    Department of Environmental Health Sciences, The Johns Hopkins School of Public Health, Baltimore, Maryland 20892 7924, USA
    Am J Respir Crit Care Med 165:27-33. 2002
    ..We conclude that heparin inhibits hyperventilation-induced late-phase changes in peripheral airway function, and does so in part via the inhibition of eosinophil migration and eicosanoid mediator production and release...
  100. ncbi Binding of radiolabeled high affinity antagonist to leukotriene D4 receptor in guinea pig lung membranes: interconversion of agonist-receptor binding affinity states
    S Mong
    Department of Pediatrics, St Christopher s Hospital For Children, Philadelphia, Pennsylvania
    Mol Pharmacol 35:795-802. 1989
    ..04 nM and 1030 +/- 180 fmol/mg, respectively. In competition studies, LTD4, stereoisomer (5R,6S)-LTD4, and leukotriene E4 (LTE4) competed with [3H]ICI-198615 binding to specific sites, with a stereoselectivity and a rank order of ..
  101. pmc Clinical and biochemical effects of a combination botanical product (ClearGuard) for allergy: a pilot randomized double-blind placebo-controlled trial
    Jonathan Corren
    Allergy Research Foundation, Los Angeles, USA
    Nutr J 7:20. 2008
    ..The current study was conducted to determine the effects of these combined ingredients upon the nasal response to allergen challenge in patients with seasonal allergic rhinitis...

Research Grants64

  1. LEUKOTRIENES AND MESSENGERS IN PHOTORECEPTOR RENEWAL
    Nicolas Bazan; Fiscal Year: 1993
    ..The results will define the involvement of second messengers in the interactions between visual cells and retinal pigment epithelium during photoreceptor renewal...
  2. LEUKOTRIENES AND MESSENGERS IN PHOTORECEPTOR RENEWAL
    Nicolas Bazan; Fiscal Year: 1992
    ..The results will define the involvement of second messengers in the interactions between visual cells and retinal pigment epithelium during photoreceptor renewal...
  3. LEUKOTRIENE SUBSTANCE P INTERACTIONS IN THE AIRWAYS
    EUNICE BLOOMQUIST; Fiscal Year: 1993
    ..Conversely, SP applied to isolated trachea elicits release of leukotriene E4 - like material...
  4. LEUKOTRIENE SUBSTANCE P INTERACTIONS IN THE AIRWAYS
    EUNICE BLOOMQUIST; Fiscal Year: 1990
    ..Conversely, SP applied to isolated trachea elicits release of leukotriene E4 - like material...
  5. URINARY LEUKOTRIENE E4 LEVELS AS MARKER OF PULMONARY DISEASE PROGRESSION IN CF
    Mark Dovey; Fiscal Year: 1999
    The purpose of this study is to determine if there is a relationship between the quantity of leukotriene E4 in urine samples and pulmonary disease status as measured by pulmonary function testing in patients with cystic fibrosis...
  6. Lipidomic and Transcriptome Signatures in Aspirin-Exacerbated Respiratory Disease
    Joshua A Boyce; Fiscal Year: 2010
    ..The bronchoconstrictor response to leukotriene E4 is increased...
  7. Lipidomic and Transcriptome Signatures in Aspirin-Exacerbated Respiratory Disease
    Joshua Boyce; Fiscal Year: 2009
    ..The bronchoconstrictor response to leukotriene E4 is increased...
  8. DRUG METABOLISM AND DETOXIFICATION IN THE EYE
    Hitoshi Shichi; Fiscal Year: 1992
    ..Similar enzymes catalyze conversion of leukotriene A4 to leukotriene E4. It is not known whether the enzymes responsible for the metabolism of xenobiotics and the endogenous ..
  9. DRUG METABOLISM AND DETOXIFICATION IN THE EYE
    Hitoshi Shichi; Fiscal Year: 1991
    ..Similar enzymes catalyze conversion of leukotriene A4 to leukotriene E4. It is not known whether the enzymes responsible for the metabolism of xenobiotics and the endogenous ..
  10. DRUG METABOLISM AND DETOXIFICATION IN THE EYE
    Hitoshi Shichi; Fiscal Year: 1990
    ..Similar enzymes catalyze conversion of leukotriene A4 to leukotriene E4. It is not known whether the enzymes responsible for the metabolism of xenobiotics and the endogenous ..
  11. NEUTROPHILS AND HEPATOTOXICITY
    Robert Roth; Fiscal Year: 1993
    ..e., parenchymal cells biliary epithelium) and effector cells (i.e., PMNs, Kupffer cells) that contribute to hepatotoxicity...
  12. NEUTROPHILS AND HEPATOTOXICITY
    Robert Roth; Fiscal Year: 1992
    ..e., parenchymal cells biliary epithelium) and effector cells (i.e., PMNs, Kupffer cells) that contribute to hepatotoxicity...
  13. Regulation of Pulmonary Prostaglandins by Leukotriene E4
    Joshua A Boyce; Fiscal Year: 2010
    ..The findings are expected to have immediate implications for asthma pathophysiology and treatment. ..
  14. Regulation of Pulmonary Prostaglandins by Leukotriene E4
    Joshua Boyce; Fiscal Year: 2009
    ..The findings are expected to have immediate implications for asthma pathophysiology and treatment. ..
  15. Cysteinyl leukotriene signaling in proliferation, cytokine production and PGD2 ge
    Sailaja Paruchuri; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: This proposal seeks to determine how a common lipid mediator leukotriene E4 can regulate the activation of mast cells, important cells mediating the inflammatory responses in response to ..
  16. Polymorphisms Related to Effects of Particulate Air Pollution In Urban Childhood
    Nathan Rabinovitch; Fiscal Year: 2010
    ..Urine leukotriene E4 levels will be collected from each child on 16 consecutive schooldays and exhaled nitric oxide will be sampled ..
  17. Polymorphisms Related to Effects of Particulate Air Pollution In Urban Childhood
    Nathan Rabinovitch; Fiscal Year: 2009
    ..Urine leukotriene E4 levels will be collected from each child on 16 consecutive schooldays and exhaled nitric oxide will be sampled ..
  18. Polymorphisms Related to Effects of Particulate Air Pollution In Urban Childhood
    Nathan Rabinovitch; Fiscal Year: 2008
    ..Urine leukotriene E4 levels will be collected from each child on 16 consecutive schooldays and exhaled nitric oxide will be sampled ..
  19. Polymorphisms Related to Effects of Particulate Air Pollution In Urban Childhood
    Nathan Rabinovitch; Fiscal Year: 2007
    ..Urine leukotriene E4 levels will be collected from each child on 16 consecutive schooldays and exhaled nitric oxide will be sampled ..
  20. NEUROGENIC INFLAMMATORY RESPONSE TO RSV
    Giovanni Piedimonte; Fiscal Year: 2008
    ..abstract_text> ..
  21. MECHANISM OF LACRIMAL GLAND SECRETION
    Darlene Dartt; Fiscal Year: 2009
    ..Knowledge about the molecules inside lacrimal gland cells that cause secretion will be critical to the development of new drugs to produce tear secretion in individuals who have dry eye resulting from aging or Sjogren's syndrome. ..
  22. CELLULAR BASIS OF HYPERSENSITIVITY DISEASES IN HUMANS
    FRANK AUSTEN; Fiscal Year: 2007
    ..abstract_text> ..
  23. Control of Conjuctival Goblet Cell Mucin Production
    Darlene Dartt; Fiscal Year: 2007
    ..Study of the signaling pathways that stimulate conjunctival goblet cell proliferation will lead to the development of treatments to replenish the mucin layer in these diseases. ..
  24. Planning Grant:Research on Blinding Eye Diseases (RMI)
    Darlene Dartt; Fiscal Year: 2006
    ..Based on these findings, an application for an Interdisciplinary Center for Research on Blinding Eye Diseases will be prepared. [unreadable] [unreadable]..
  25. MECHANISMS OF SMOOTH MUSCLE HYPERREACTIVITY ON ASTHMA
    Prescott Woodruff; Fiscal Year: 2006
    ..The candidate will complement these studies with a curriculum of advanced training in methods for the design and analysis of gene expression studies in human subjects. ..
  26. Molecular Phenotyping of Asthma
    Prescott Woodruff; Fiscal Year: 2008
    ..The ultimate goal of these cell culture studies is to identify new therapies for asthma. (End of Abstract) ..
  27. Molecular Phenotyping of Asthma
    Prescott G Woodruff; Fiscal Year: 2010
    ..The ultimate goal of these cell culture studies is to identify new therapies for asthma. (End of Abstract) ..
  28. Role of Th2 and non-Th2 Inflammation in Airway Smooth Muscle Remodeling in Asthma
    Prescott G Woodruff; Fiscal Year: 2010
    ..End of Abstract) ..
  29. Molecular Phenotyping of Asthma
    Prescott Woodruff; Fiscal Year: 2009
    ..The ultimate goal of these cell culture studies is to identify new therapies for asthma. (End of Abstract) ..
  30. Control of Conjuctival Goblet Cell Mucin Production
    Darlene Dartt; Fiscal Year: 2009
    ..Study of the signaling pathways that stimulate conjunctival goblet cell proliferation will lead to the development of treatments to replenish the mucin layer in these diseases. ..
  31. Conjunctival Goblet Cell Mucin Secretion in Inflammation and Its Resolution
    Darlene A Dartt; Fiscal Year: 2010
    ..This will provide significant insights into developing novel treatments for ocular surface inflammation. ..
  32. MECHANISM OF LACRIMAL GLAND SECRETION
    Darlene Dartt; Fiscal Year: 2009
    ..There is no cure for dry eye and as the lacrimal gland is the primary contributor to the aqueous layer of the tear film, replacement of a diseased lacrimal gland using stem cells would improve the health of the ocular surface. ..
  33. Role of Th2 and non-Th2 Inflammation in Airway Smooth Muscle Remodeling in Asthma
    Prescott Woodruff; Fiscal Year: 2009
    ..End of Abstract) ..
  34. Molecular Phenotyping of Asthma
    Prescott Woodruff; Fiscal Year: 2009
    ..The ultimate goal of these cell culture studies is to identify new therapies for asthma. (End of Abstract) ..
  35. NEUROGENIC INFLAMMATORY RESPONSE TO RSV
    Giovanni Piedimonte; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  36. Control of Conjuctival Goblet Cell Mucin Production
    Darlene Dartt; Fiscal Year: 2005
    ..Study of the signaling pathways that stimulate conjunctival goblet cell proliferation will lead to the development of treatments to replenish the mucin layer in these diseases. ..
  37. MECHANISM OF LACRIMAL GLAND SECRETION
    Darlene Dartt; Fiscal Year: 1999
    ....
  38. CONTROL OF CONJUNCTIVAL GOBLET CELL MUCOUS PRODUCTION
    Darlene Dartt; Fiscal Year: 1993
    ....
  39. MECHANISM OF LACRIMAL GLAND SECRETION
    Darlene Dartt; Fiscal Year: 1992
    ....
  40. MECHANISM OF LACRIMAL GLAND SECRETION
    Darlene Dartt; Fiscal Year: 1993
    ....
  41. CONTROL OF CONJUNCTIVAL GOBLET CELL MUCOUS PRODUCTION
    Darlene Dartt; Fiscal Year: 1991
    ....
  42. MECHANISM OF LACRIMAL GLAND SECRETION
    Darlene Dartt; Fiscal Year: 2005
    ..lmmunofluorescence microscopy, Western and Northern blot analysis, and RT-PCR will be used to determine how the expression and release of EGF and its family members is regulated. ..
  43. MECHANISMS OF SMOOTH MUSCLE HYPERREACTIVITY ON ASTHMA
    Prescott Woodruff; Fiscal Year: 2005
    ..The candidate will complement these studies with a curriculum of advanced training in methods for the design and analysis of gene expression studies in human subjects. ..
  44. MECHANISM OF LACRIMAL GLAND SECRETION
    Darlene Dartt; Fiscal Year: 2003
    ..lmmunofluorescence microscopy, Western and Northern blot analysis, and RT-PCR will be used to determine how the expression and release of EGF and its family members is regulated. ..
  45. IMMUNOLOGIC BASIS OF RESISTANCE AND HYPERSENSITIVITY
    FRANK AUSTEN; Fiscal Year: 2007
    ..Support is again requested for eight postdoctoral trainees having either a M.D. or Ph.D. degree or both and one predoctoral trainee. ..
  46. NEUROGENIC INFLAMMATORY RESPONSE TO RSV
    Giovanni Piedimonte; Fiscal Year: 2002
    ..These studies may provide important information concerning the mechanisms of post- RSV childhood asthma. ..
  47. MECHANISM OF LACRIMAL GLAND SECRETION
    Darlene Dartt; Fiscal Year: 2002
    ..lmmunofluorescence microscopy, Western and Northern blot analysis, and RT-PCR will be used to determine how the expression and release of EGF and its family members is regulated. ..
  48. NEUROGENIC INFLAMMATORY RESPONSE TO RSV
    Giovanni Piedimonte; Fiscal Year: 2001
    ..These studies may provide important information concerning the mechanisms of post- RSV childhood asthma. ..
  49. MECHANISM OF LACRIMAL GLAND SECRETION
    Darlene Dartt; Fiscal Year: 2001
    ..lmmunofluorescence microscopy, Western and Northern blot analysis, and RT-PCR will be used to determine how the expression and release of EGF and its family members is regulated. ..
  50. NEUROGENIC INFLAMMATORY RESPONSE TO RSV
    Giovanni Piedimonte; Fiscal Year: 1999
    ..These studies may provide important information concerning the mechanisms of post- RSV childhood asthma. ..
  51. IMMUNOLOGIC BASIS OF RESISTANCE AND HYPERSENSITIVITY
    FRANK AUSTEN; Fiscal Year: 2008
    ..Characterization of these proinflammatory pathways allows for therapeutic approaches based on targeted intervention. ..
  52. Keystone Symposium: Eicosanoid Lipid Mediators
    Jilly Evans; Fiscal Year: 2003
    ..NIH support for this meeting will allow more graduate student and postdoctoral participation in.this exciting multidisciplinary meeting. ..