Genomes and Genes
unsaturated fatty acids
Summary: FATTY ACIDS in which the carbon chain contains one or more double or triple carbon-carbon bonds.
Publications296 found, 100 shown here
- Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved regionN Kudo
Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
Proc Natl Acad Sci U S A 96:9112-7. 1999..These results show that the single cysteine residue determines LMB sensitivity and is selectively alkylated by LMB, leading to CRM1 inactivation...
- Protein ligands to HuR modulate its interaction with target mRNAs in vivoC M Brennan
Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA
J Cell Biol 151:1-14. 2000..We discuss the possible role of these ligands upstream of HuR in pathways that govern the stability of ARE-containing mRNAs...
- Cardiovascular disease risk of dietary stearic acid compared with trans, other saturated, and unsaturated fatty acids: a systematic reviewJ Edward Hunter
Department of Chemistry University of Cincinnati Cincinnati OH 45221 0172, USA
Am J Clin Nutr 91:46-63. 2010..High stearic acid (STA) soybean oil is a trans-free, oxidatively stable, non-LDL-cholesterol-raising oil that can be used to replace trans fatty acids (TFAs) in solid fat applications...
- CRM1 is an export receptor for leucine-rich nuclear export signalsM Fornerod
European Molecular Biology Laboratory, Heidelberg, Germany
Cell 90:1051-60. 1997..We conclude that CRM1 is an export receptor for leucine-rich nuclear export signals and discuss a model for the role of RanGTP in CRM1 function and in nuclear export in general...
- Stimulation of mitochondrial reactive oxygen species production by unesterified, unsaturated fatty acids in defective human spermatozoaAdam J Koppers
Discipline of Biological Sciences and ARC Centre of Excellence in Biotechnology and Development, Faculty of Science and IT, University of Newcastle, Callaghan, NSW 2308, Australia
Free Radic Biol Med 48:112-9. 2010..001). This relationship was causal and mediated by the range of unesterified, unsaturated fatty acids that are present in human spermatozoa...
- PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanismManlio Vinciguerra
Department of Cell Physiology and Metabolism, Geneva Medical Faculty, Geneva University Hospital, Switzerland
Gastroenterology 134:268-80. 2008..Here, we investigated the pathophysiologic mechanisms regulating PTEN expression in the liver and the development of steatosis...
- Fatty acid synthesis is a target for antibacterial activity of unsaturated fatty acidsChang Ji Zheng
Korea Research Institute of Bioscience and Biotechnology, P O Box 115, Yusong, Daejeon 305 600, Republic of Korea
FEBS Lett 579:5157-62. 2005Long-chain unsaturated fatty acids, such as linoleic acid, show antibacterial activity and are the key ingredients of antimicrobial food additives and some antibacterial herbs...
- Polyunsaturated fatty acid regulation of genes of lipid metabolismHarini Sampath
Department of Nutritional Sciences, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
Annu Rev Nutr 25:317-40. 2005..Working out the mechanisms by which these interactions and consequent effects occur is proving to be complicated but is invaluable to our understanding of the role that dietary fat can play in disease management and prevention...
- Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a phospholipase D2 pathwayYutong Wang
Department of Medicine, University of Washington, Seattle, Washington 98195, USA
J Biol Chem 280:35896-903. 2005..b>Unsaturated fatty acids, which are elevated in diabetes, impair the ABCA1 pathway in cultured cells by destabilizing ABCA1 ..
- RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channelsNiels Decher
Institut fur Physiologie und Pathophysiologie, Universitat Marburg, Marburg, Germany
EMBO J 29:2101-13. 2010..x channels. Our findings provide a mechanistic understanding of lipid-induced inactivation and establish RNA editing as a mechanism to induce drug and lipid resistance in Kv channels...
- Different role of saturated and unsaturated fatty acids in beta-cell apoptosisKatrin Eitel
Internal Medicine IV, University of Tubingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
Biochem Biophys Res Commun 299:853-6. 2002..Cells were incubated for 24-72 h with 1mM fatty acids. All unsaturated fatty acids tested completely prevented palmitate- or stearate-induced apoptosis of rat and human beta-cells as ..
- Myristoylation as a target for inhibiting HIV assembly: unsaturated fatty acids block viral buddingO Wolf Lindwasser
Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 143, New York, NY 10021, USA
Proc Natl Acad Sci U S A 99:13037-42. 2002..Furthermore, treatment of cells with 14-carbon unsaturated fatty acids inhibited Gag-driven particle assembly...
- Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elementsTomohiro Yoshikawa
Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
J Biol Chem 277:1705-11. 2002..acid > eicosapentaenoic acid > docosahexaenoic acid > linoleic acid), whereas saturated or mono-unsaturated fatty acids had minimal effects...
- Endothelial lipase releases saturated and unsaturated fatty acids of high density lipoprotein phosphatidylcholineM Gauster
Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University Graz, Harrachgasse 21 III, Graz A 8010, Austria
J Lipid Res 46:1517-25. 2005....
- A bifunctional Delta12,Delta15-desaturase from Acanthamoeba castellanii directs the synthesis of highly unusual n-1 series unsaturated fatty acidsOlga Sayanova
Rothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, United Kingdom
J Biol Chem 281:36533-41. 2006..The presence of a bifunctional Delta12,Delta15-desaturase in A. castellanii is also considered with reference to the evolution of desaturases and the lineage of this protist...
- Bio-markers of lipid peroxidation in vivo: hydroxyoctadecadienoic acid and hydroxycholesterolYasukazu Yoshida
National Institute of Advanced Industrial Science and Technology AIST, Human Stress Signal Research Center, 1 8 31 Midorigaoka, Ikeda 563 8577, Japan
Biofactors 27:195-202. 2006..In addition to this advantage, hydrogen-donor activity of antioxidants in vivo could be determined by the isomeric-ratio of HODE (9- and 13-(Z,E)-HODE/9- and 13-(E,E)-HODE)...
- Krabbe disease: psychosine-mediated activation of phospholipase A2 in oligodendrocyte cell deathS Giri
Department of Pediatrics, Charles P Darby Children s Research Institute, Medical University of South Carolina, Charleston, 29425, USA
J Lipid Res 47:1478-92. 2006....
- Fatty acid elongases in mammals: their regulation and roles in metabolismAndreas Jakobsson
The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 10691 Stockholm, Sweden
Prog Lipid Res 45:237-49. 2006..We will consider both the biochemical functions of the proteins, as well as their role in a more physiological context...
- Unsaturated fatty acids inhibit cholesterol efflux from macrophages by increasing degradation of ATP-binding cassette transporter A1Yutong Wang
Department of Medicine, University of Washington, Seattle, Washington 98195, USA
J Biol Chem 277:5692-7. 2002..Results showed that unsaturated fatty acids markedly inhibited ABCA1-mediated cholesterol and phospholipid efflux from macrophages when ABCA1 was ..
- Induction of the Arabidopsis PHO1;H10 gene by 12-oxo-phytodienoic acid but not jasmonic acid via a CORONATINE INSENSITIVE1-dependent pathwayCecile Ribot
Département de Biologie Moléculaire Végétale, Biophore, Universite de Lausanne, CH 1015 Lausanne, Switzerland
Plant Physiol 147:696-706. 2008..Furthermore, the implication of the ABA pathway in coregulating AtPHO1;H10 expression is dependent on the abiotic stress applied, being weak under wounding but strong upon dehydration...
- Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4J Y Lee
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
J Biol Chem 276:16683-9. 2001..7). Results show that SFAs, but not unsaturated fatty acids (UFAs), induce nuclear factor kappaB activation and expression of COX-2 and other inflammatory markers...
- The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic beta-cellsNoel G Morgan
Institute of Biomedical and Clinical Science, Peninsula Medical School, Plymouth PL6 8BU, UK
Biochem Soc Trans 36:905-8. 2008..However, when incubated in vitro, beta-cells respond differentially to long-chain saturated and mono-unsaturated fatty acids, suggesting that these molecules may regulate cell functionality by different mechanisms...
- Production of polyunsaturated fatty acids by polyketide synthases in both prokaryotes and eukaryotesJ G Metz
Omega Tech, 4909 Nautilus Court North, Boulder, CO 80301 3242, USA
Science 293:290-3. 2001..It is likely that PUFA synthesis in cold marine ecosystems is accomplished in part by these PKS enzymes...
- Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's diseaseFrederic Calon
Department of Medicine, University of California, Los Angeles, California, USA
Eur J Neurosci 22:617-26. 2005..The marked effect of dietary n-3 PFA on NMDA receptors and caspase/calpain activation in the cortex of an animal model of AD provide new insights into how dietary essential fatty acids may influence cognition and AD risk...
- The role of n-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary n-3 fatty acidsKlara Kitajka
Institute of Biochemistry, and DNA Chip Laboratory, Biological Research Center, Hungarian Academy of Sciences, P O Box 521, H 6701 Szeged, Hungary
Proc Natl Acad Sci U S A 99:2619-24. 2002....
- Juvenoid hormone methyl farnesoate is a sex determinant in the crustacean Daphnia magnaAllen W Olmstead
Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695 7633, USA
J Exp Zool 293:736-9. 2002..These results demonstrate that methyl farnesoate is capable of programming daphnid embryos to develop into males and is likely the endocrine factor responsible for initiating the sexual reproductive phase in these organisms...
- Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammationSong Hong
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 278:14677-87. 2003..These results indicate that DHA is the precursor to potent protective mediators generated via enzymatic oxygenations to novel docosatrienes and 17S series resolvins that each regulate events of interest in inflammation and resolution...
- Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTENManlio Vinciguerra
Department of Cellular Physiology and Metabolism, Faculty of Medicine, University of Geneva, CMU, 1 rue Michel Servet, 1211 Geneva, Switzerland
J Hepatol 50:1132-41. 2009..We recently demonstrated that unsaturated fatty acids trigger the downregulation of the tumor suppressor PTEN through an mTOR/NF-kappaB-dependent mechanism in ..
- Is obesity an inflammatory condition?U N Das
EFA Sciences LLC, Norwood, Massachusets 02062, USA
Nutrition 17:953-66. 2001....
- Plant defense in the absence of jasmonic acid: the role of cyclopentenonesA Stintzi
Institute of Biological Chemistry, Washington State University, Pullman, WA 99164-6340, USA
Proc Natl Acad Sci U S A 98:12837-42. 2001..More generally, resistance to insect and fungal attack can be observed in the absence of JA...
- Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trialsRonald P Mensink
Department of Human Biology, Maastricht University, Maastricht, Netherlands
Am J Clin Nutr 77:1146-55. 2003..Fats, however, also affect HDL cholesterol, and the ratio of total to HDL cholesterol is a more specific marker of CAD than is LDL cholesterol...
- Docosahexaenoic acid promotes neurite growth in hippocampal neuronsFrances Calderon
Section of Mass Spectrometry, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
J Neurochem 90:979-88. 2004..Our data demonstrates that DHA uniquely promotes neurite growth in hippocampal neurons. Inadequate neurite development due to DHA deficiency may contribute to the cognitive impairment associated with n-3 fatty acid deficiency...
- Roles of unsaturated fatty acids (especially omega-3 fatty acids) in the brain at various ages and during ageingJ M Bourre
INSERM Research Director Unit U26 Neuro pharmaco nutrition Hopital Fernand Widal, 200 rue du Faubourg Saint Denis 75745 Paris cedex 10
J Nutr Health Aging 8:163-74. 2004..Peroxisomal oxidation of polyunsaturated fatty acids decreases in the brain during ageing, participating in decreased turnover of membrane fatty acids, which are also less effectively protected against peroxidation by free radicals...
- Nucleocytoplasmic shuttling of the thyroid hormone receptor alphaC F Bunn
Department of Zoology, University of Canterbury, Christchurch, New Zealand 8001
Mol Endocrinol 15:512-33. 2001..Acquisition of altered nuclear export capabilities may contribute to the oncogenic properties of v-ErbA...
- Novel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectinsCharles N Serhan
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Curr Opin Clin Nutr Metab Care 8:115-21. 2005..Many clinical studies suggest that omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid have beneficial actions in human diseases. The molecular basis of these actions remains of interest...
- Suppression of ABCA1 by unsaturated fatty acids leads to lipid accumulation in HepG2 cellsYanhong Yang
Department of Cell Biology, Municipal Laboratory for Liver Protection and Regulation of Regeneration, Capital Medical University, Beijing 100069, China
Biochimie 92:958-63. 2010..We previously reported that unsaturated fatty acids destabilise ABCA1 in murine macrophages and ABCA1-transfected baby hamster kidney cells by increasing its ..
- Altered fatty acid compositions in atlantic salmon (Salmo salar) fed diets containing linseed and rapeseed oils can be partially restored by a subsequent fish oil finishing dietJ Gordon Bell
Institute of Aquaculture, University of Stirling, Stirling, FK9 4LA, Scotland, UK
J Nutr 133:2793-801. 2003..Inclusion of vegetable oil at 33% of total oil significantly reduced the concentrations of the highly unsaturated fatty acids, eicosapentaenoate [20:5(n-3)] and docosahexaenoate [22:6(n-3)], to approximately 70 and 75%, ..
- Protein ligands mediate the CRM1-dependent export of HuR in response to heat shockI E Gallouzi
Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA
RNA 7:1348-61. 2001..HuR and its ligands may be instrumental in the nuclear export of heat-shock mRNAs...
- Cis-unsaturated fatty acids stimulate reactive oxygen species generation and lipid peroxidation in human spermatozoaR John Aitken
Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
J Clin Endocrinol Metab 91:4154-63. 2006..there are also data indicating that defective human spermatozoa contain abnormally high amounts of cis-unsaturated fatty acids. This study investigated whether a causative relationship exists between these two attributes of impaired ..
- Calreticulin Is a receptor for nuclear exportJ M Holaska
Center for Cell Signaling, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
J Cell Biol 152:127-40. 2001..CRT defines a new export pathway that may regulate the transcriptional activity of steroid hormone receptors...
- Dyslipidemia, but not hyperglycemia, induces inflammatory adhesion molecules in human retinal vascular endothelial cellsWeiqin Chen
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824, USA
Invest Ophthalmol Vis Sci 44:5016-22. 2003..The purpose of this study was to examine the effect of fatty acids and hyperglycemia on human retinal vascular endothelial (hRVE) cells as a means of mimicking diabetic metabolic disorders...
- Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylationM Itoh
First Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, 060 8543, Japan
Mol Endocrinol 16:2382-92. 2002..Taken together, these findings suggest that JNK-mediated phosphorylation of the GR-Ser226 enhances GR nuclear export and may contribute to termination of GR-mediated transcription...
- Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologiesH Tapiero
UNIVERSITE DE PARIS, Faculté de Pharmacie CNRS UMR 8612, Chatenay Malabry, France
Biomed Pharmacother 56:215-22. 2002....
- A novel tetratricopeptide repeat (TPR) containing PP5 serine/threonine protein phosphatase in the malaria parasite, Plasmodium falciparumS Dobson
Department of Biochemistry and Molecular Biology, University of South Alabama, College of Medicine, 307 University Blvd, Mobile, Alabama 36688 0002, USA
BMC Microbiol 1:31. 2001..Recent discovery of a few protein kinases and phosphatases point to a thriving reversible phosphorylation system in the parasite, although their function and regulation need to be determined...
- Lipid peroxidation and the thiobarbituric acid assay: standardization of the assay when using saturated and unsaturated fatty acidsLeonard T Rael
Department of Trauma Research and Trauma Services, Swedish Medical Center, 501 E Hampden Avenue, Englewood, CO 80113, USA
J Biochem Mol Biol 37:749-52. 2004..The rate of TBARS inhibition was greater for the saturated than for unsaturated fatty acids, as measured from the slope of the linear range...
- Evidence that unsaturated fatty acids are potent inhibitors of renal UDP-glucuronosyltransferases (UGT): kinetic studies using human kidney cortical microsomes and recombinant UGT1A9 and UGT2B7Paraskevi Tsoutsikos
Department of Clinical Pharmacology, Flinders University and Flinders Medical Centre, Bedford Park, 5042, Adelaide, Australia
Biochem Pharmacol 67:191-9. 2004..It is conceivable therefore that during periods of renal ischaemia FA may impair renal drug glucuronidation thus compromising the protective capacity of the kidney against drug-induced nephrotoxicity...
- The cis-trans isomerase of unsaturated fatty acids in Pseudomonas and Vibrio: biochemistry, molecular biology and physiological function of a unique stress adaptive mechanismHermann J Heipieper
Department of Bioremediation, Centre for Environmental Research UFZ Leipzig Halle, Permoserstr 15, 04318 Leipzig, Germany
FEMS Microbiol Lett 229:1-7. 2003Isomerization of cis to trans unsaturated fatty acids is a mechanism enabling Gram-negative bacteria belonging to the genera Pseudomonas and Vibrio to adapt to several forms of environmental stress...
- Unsaturated fatty acids and their oxidation products stimulate CD36 gene expression in human macrophagesJoan Carles Vallvé
Unitat de Recerca de Lipids i Arteriosclerosi, Facultat de Medicina, Universitat Rovira i Virgili, Sant Llorenc 21, 43201, Catalonia, Reus, Spain
Atherosclerosis 164:45-56. 2002..In contrast, DDE and HNE significantly decreased this parameter. The data provide evidence for a direct regulatory effect of UFA on CD36 gene expression and support a role for aldehydes in the regulation of CD36 expression by FA...
- Greater enrichment of triacylglycerol-rich lipoproteins with apolipoproteins E and C-III after meals rich in saturated fatty acids than after meals rich in unsaturated fatty acidsKim G Jackson
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Reading, UK
Am J Clin Nutr 81:25-34. 2005....
- LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1Yutong Wang
Department of Medicine, University of Washington, Seattle, WA 98195, USA
J Lipid Res 45:972-80. 2004..Thus, with cholesterol-loaded macrophages exposed to saturated fatty acids, activated LXR/RXR may counteract the enhanced ABCA1 transcription by reducing the ABCA1 protein content...
- Escherichia coli FadR positively regulates transcription of the fabB fatty acid biosynthetic geneJ W Campbell
Departments of Microbiologyand, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
J Bacteriol 183:5982-90. 2001..These experiments demonstrate that expression of fabB is positively regulated by FadR...
- Role of nonesterified unsaturated fatty acids in the pathophysiological processes of leptospiral infectionPatricia Burth
Department of Cellular and Molecular Biology, Biology Institute, Universidade Federal Fluminense, Niteroi, Brazil
J Infect Dis 191:51-7. 2005..Our data support the concept that the administration of human albumin to patients may be helpful in severe leptospirosis cases...
- An extraordinary degree of structural specificity is required in neural phospholipids for optimal brain function: n-6 docosapentaenoic acid substitution for docosahexaenoic acid leads to a loss in spatial task performanceSun Young Lim
Division of Marine Environment and Bioscience, Korea Maritime University, Busan, Korea
J Neurochem 95:848-57. 2005..In conclusion, DPAn-6 could not replace DHA for brain function, indicating a highly specific structural requirement for DHA...
- Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a protein kinase C delta pathwayYutong Wang
Department of Medicine, University of Washington, Seattle, WA 98195, USA
J Lipid Res 48:1062-8. 2007..b>Unsaturated fatty acids, which are increased in diabetes, impair the ABCA1 pathway in cultured cells by destabilizing ABCA1 ..
- Unsaturated fatty acids selectively induce an inflammatory environment in human endothelial cellsMichal Toborek
Department of Surgery, University of Kentucky Medical Center, Lexington 40536, USA
Am J Clin Nutr 75:119-25. 2002..However, the specific effects of fatty acids on inflammatory responses in endothelial cells are not fully understood...
- Induction of peroxisomal proliferator-activated receptor gamma and peroxisomal proliferator-activated receptor gamma coactivator 1 by unsaturated fatty acids, retinoic acid, and carotenoids in preadipocytes obtained from bovine white adipose tissue1,2P García-Rojas
Programa de Posgrado en Ciencias de la Producción y de la Salud Animal, Universidad Nacional Autonoma de Mexico, Mexico City 04510, Mexico
J Anim Sci 88:1801-8. 2010..differentiation after reaching confluence was induced by various treatments: rosiglitazone (20 microM); unsaturated fatty acids: phytanic acid (25, 50, 100 microM) and pristanic acid (25, 50, 100 microM); retinoids: 9-cis retinoic ..
- De novo lipogenesis and stearoyl-CoA desaturase are coordinately regulated in the human adipocyte and protect against palmitate-induced cell injuryJennifer M Collins
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, United Kingdom
J Biol Chem 285:6044-52. 2010..DNL may not act primarily to increase fat stores but may serve as a key regulator, in tandem with elongation and desaturation, to maintain cell membrane fluidity and insulin sensitivity within the human adipocyte...
- Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce beta-oxidation in white fatP Flachs
Department of Adipose Tissue Biology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Diabetologia 48:2365-75. 2005....
- Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination stepJoon No Lee
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Biol Chem 283:33772-83. 2008..Here we show that unsaturated fatty acids stabilize Insig-1 without affecting its ubiquitination...
- Effects of dietary palmitoleic acid on plasma lipoprotein profile and aortic cholesterol accumulation are similar to those of other unsaturated fatty acids in the F1B golden Syrian hamsterNirupa R Matthan
Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
J Nutr 139:215-21. 2009..These data suggest that an oil relatively high in palmitoleic acid does not adversely affect plasma lipoprotein profiles or aortic cholesterol accumulation and was similar to other unsaturated fatty acid-rich oils...
- Effect of fatty acids on phase behavior of hydrated dipalmitoylphosphatidylcholine bilayer: saturated versus unsaturated fatty acidsT Inoue
Department of Chemistry, Faculty of Science, Fukuoka University, Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
Chem Phys Lipids 109:117-33. 2001..DPPC) bilayer was investigated with special interest in possible difference between saturated and unsaturated fatty acids. The phase behavior of hydrated DPPC bilayer was followed by a differential scanning calorimetry and a ..
- Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and womenTobias Pischon
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, Mass 02115, USA
Circulation 108:155-60. 2003..Polyunsaturated fatty acid intake favorably affects chronic inflammatory-related diseases such as cardiovascular disease; however, high intake of n-6 fatty acids may attenuate the known beneficial effects of n-3 fatty acids...
- Nutrigenomic approach to understanding the mechanisms by which dietary long-chain fatty acids induce gene signals and control mechanisms involved in carcinogenesisPascale Anderle
Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland
Nutrition 20:103-8. 2004
- Lipid mediators from pollen act as chemoattractants and activators of polymorphonuclear granulocytesClaudia Traidl-Hoffmann
Division of Environmental Dermatology and Allergy TUM GSF, Neuherberg, Germany
J Allergy Clin Immunol 109:831-8. 2002..In addition, we recently demonstrated that pollen are a rich source of eicosanoid-like mediators, which are rapidly released on contact with the aqueous phase...
- Polyunsaturated fatty acid biosynthesis: a microsomal-peroxisomal processH Sprecher
The Department of Medical Biochemistry, The Ohio State University, Columbus 43210, USA
Prostaglandins Leukot Essent Fatty Acids 60:317-21. 1999..Collectively our findings suggest that there may be considerably more recycling of fatty acids between peroxisomes and the endoplasmic reticulum than was previously recognized...
- beta-oxidation - strategies for the metabolism of a wide variety of acyl-CoA estersJ K Hiltunen
Biocenter Oulu and Department of Biochemistry, University of Oulu, P O FIN 90014, Oulun yliopisto, Finland
Biochim Biophys Acta 1484:117-28. 2000....
- n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytesE D Collett
Molecular and Cell Biology Group, Faculty of Nutrition, and Center for Environmental and Rural Health, Texas A and M University, College Station, Texas 77843-2471, USA
Am J Physiol Cell Physiol 280:C1066-75. 2001..In view of the central role of oncogenic Ras in the development of colon cancer, the finding that n-3 and n-6 PUFA differentially modulate Ras activation may partly explain why dietary fish oil protects against colon cancer development...
- Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseasesPhilip C Calder
Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, UK
Mol Nutr Food Res 52:885-97. 2008..Clinical outcomes have been variably affected by fish oil, although some trials report improved gut histology, decreased disease activity, use of corticosteroids and relapse...
- A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49Marc R Van Gilst
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143 2280, USA
Proc Natl Acad Sci U S A 102:13496-501. 2005..Our characterization of a fasting response system and our finding that nhr-49 regulates a sector within this system provide insight into the mechanisms by which animals respond to nutritional signals...
- Product diversity and regulation of type II fatty acid synthasesYing Jie Lu
Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Biochem Cell Biol 82:145-55. 2004..These include multiple mechanisms to generate unsaturated fatty acids and the accessory components required for branched-chain fatty acid synthesis in Gram-positive bacteria...
- A rapid wound signal activates the systemic synthesis of bioactive jasmonates in ArabidopsisAbraham J K Koo
Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824, USA
Plant J 59:974-86. 2009..These results are consistent with a model in which a rapidly transmitted wound signal triggers the systemic synthesis of JA, which, upon conversion to JA-Ile, activates the expression of early response genes by the SCF(COI1)/JAZ pathway...
- Unsaturated fatty acids as cytoprotective agents in the pancreatic beta-cellNoel G Morgan
Institute of Biomedical and Clinical Science, Peninsula Medical School University of Exeter, Plymouth, UK
Prostaglandins Leukot Essent Fatty Acids 82:231-6. 2010..to long chain fatty acids, such that saturated species are lipotoxic whereas long chain mono-unsaturated fatty acids can provide cytoprotection...
- Elucidation of the double-bond position of long-chain unsaturated fatty acids by multiple-stage linear ion-trap mass spectrometry with electrospray ionizationFong Fu Hsu
Mass Spectrometry Resource, Division of Endocrinology, Diabetes, Metabolism, and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Am Soc Mass Spectrom 19:1673-80. 2008..the position of double bond(s) of unsaturated long-chain fatty acids and toward discerning among isomeric unsaturated fatty acids as dilithiated adduct ([M-H+2Li]+) ions are described in this report...
- Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPLS Chyb
Cambridge University Department of Anatomy, UK
Nature 397:255-9. 1999..As arachidonic acid may not be found in Drosophila, we suggest that another polyunsaturated fatty acid, such as linolenic acid, may be a messenger of excitation in Drosophila photoreceptors...
- Molecular identification and characterization of the Arabidopsis delta(3,5),delta(2,4)-dienoyl-coenzyme A isomerase, a peroxisomal enzyme participating in the beta-oxidation cycle of unsaturated fatty acidsSimon Goepfert
Département de Biologie Moléculaire Végétale, Batiment de Biologie, Universite de Lausanne, CH 1015 Lausanne, Switzerland
Plant Physiol 138:1947-56. 2005Degradation of unsaturated fatty acids through the peroxisomal beta-oxidation pathway requires the participation of auxiliary enzymes in addition to the enzymes of the core beta-oxidation cycle...
- CRM1-dependent nuclear export and dimerization with hMSH5 contribute to the regulation of hMSH4 subcellular localizationSophie Neyton
Equipe M3R, UMR 6543, Universite de Nice Sophia Antipolis, CNRS, Faculte de Medecine, Avenue de Valombrose 06107, Nice Cedex 2, France
Exp Cell Res 313:3680-93. 2007..Our findings suggest that nucleocytoplasmic traffic may constitute a regulatory mechanism for MSH4 and MSH5 functions...
- Evaluation of lipophilic antioxidant efficacy in vivo by the biomarkers hydroxyoctadecadienoic acid and isoprostaneYasukazu Yoshida
Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31 Midorigaoka Ikeda, Osaka 563 8577, Japan
Lipids 42:463-72. 2007....
- Docosapentaenoic acid does not completely replace DHA in n-3 FA-deficient rats during early developmentRebecca S Greiner
Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, USA
Lipids 38:431-5. 2003..The lack of total 22-carbon (22C) FA in the brain during the rapid membrane biogenesis that occurs during early development could be a factor in the nervous system functional deficits associated with n-3 FA deficiency...
- Effects of three different highly purified n-3 series highly unsaturated fatty acids on lipid metabolism in C57BL/KsJ-db/db miceNaohiro Gotoh
Department of Food Science and Technology, Tokyo University of Marine Science and Technology, 4 5 7 Konan, Minato ku, Tokyo 108 8477, Japan
J Agric Food Chem 57:11047-54. 2009Triglycerides (TG) consisting of highly purified (>97%) n-3 series highly unsaturated fatty acids, eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA), were administered to C57BL/KsJ-db/db mice for ..
- Two aerobic pathways for the formation of unsaturated fatty acids in Pseudomonas aeruginosaKun Zhu
Department of Infectious Diseases, Protein Science Division, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Mol Microbiol 60:260-73. 2006....
- RNA helicase p54 (DDX6) is a shuttling protein involved in nuclear assembly of stored mRNP particlesDavid A Smillie
Division of Cell and Molecular Biology, School of Biology, University of St Andrews, St Andrews, Fife KY16 9TS, Scotland
J Cell Sci 115:395-407. 2002....
- Docosahexaenoic acid abundance in the brain: a biodevice to combat oxidative stressEphraim Yavin
Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
Nutr Neurosci 5:149-57. 2002..A neuroprotective role for DHA, possibly in association with the vinyl ether (VE) linkage of plasmalogens (pPLs) in combating free radicals is proposed...
- Effects of altering dietary fatty acid composition on prostaglandin synthesis and fertilityD R Abayasekara
Reproduction and Development Group, Department of Veterinary Basic Sciences, Royal Veterinary College, London, UK
Prostaglandins Leukot Essent Fatty Acids 61:275-87. 1999..In the male most recent work has focussed on sperm production and experiments in fowl have demonstrated clear effects of dietary PUFAs on both the sperm membrane phospholipid composition and on fertilizing ability...
- Relationships between the fatty acid composition of muscle and erythrocyte membrane phospholipid in young children and the effect of type of infant feedingL A Baur
Department of Paediatrics and Child Health, University of Sydney NSW, Australia
Lipids 35:77-82. 2000....
- In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activationMichael Maes
M Care4U Outpatient Clinics, and the Clinical Research Center for Mental Health, Antwerp, Belgium
Neuro Endocrinol Lett 26:745-51. 2005There is now evidence that major depression is accompanied by decreased levels of omega3 poly-unsaturated fatty acids (PUFA), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)...
- Effects of unsaturated fatty acids on progesterone secretion and selected protein kinases in goat granulosa cellsS Coyral-Castel
Institut National de la Recherche Agronomique, UMR 85 Physiologie de la Reproduction et des Comportements, Nouzilly, France
Domest Anim Endocrinol 38:272-83. 2010..Taken together, some fatty acids could improve ovarian steroidogenesis through the MAPK ERK1/2 signaling pathway and, consequently, have beneficial effects on goat fertility...
- Omega-3 PUFA of marine origin limit diet-induced obesity in mice by reducing cellularity of adipose tissueJana Ruzickova
Department of Adipose Tissue Biology and Centre for Integrated Genomics, Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic
Lipids 39:1177-85. 2004..Increased dietary intake of EPA/DHA may be beneficial regardless of the ALA intake...
- cis-trans isomerization of unsaturated fatty acids: cloning and sequencing of the cti gene from Pseudomonas putida P8R Holtwick
Institut fur Mikrobiologie, Westfalische Wilhelms Universitat Munster, Germany
Appl Environ Microbiol 63:4292-7. 1997..putida P8. A cti-carrying fragment integrated into a plasmid also conferred the ability for cis-trans isomerization to Escherichia coli; the cti gene was completely sequenced, and the amino acid sequence was deduced...
- Diets enriched in unsaturated fatty acids enhance early embryonic development in lactating Holstein cowsG Thangavelu
Dairy Research and Technology Centre, Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alta, Canada
Theriogenology 68:949-57. 2007..4+/-6.3, 132.3+/-8.3, and 89.3+/-9.6 cells, respectively). Although our hypothesis was only partially supported, embryonic development was enhanced in Holstein cows fed unsaturated fatty acids compared to those fed saturated fatty acids.
- Retinoid X receptor dominates the nuclear import and export of the unliganded vitamin D receptorKirsten Prüfer
Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Endocrinol 16:1738-51. 2002..These results indicate that the unliganded and liganded VDR interact differently with the import and export receptors and with RXR. Most likely, the regulation of VDR nuclear import by RXR is essential for ligand-independent functions...
- Board-invited review: Recent advances in biohydrogenation of unsaturated fatty acids within the rumen microbial ecosystemT C Jenkins
Department of Animal and Veterinary Sciences, Clemson University, Clemson, SC 29634, USA
J Anim Sci 86:397-412. 2008..now available, several attempts have been made at modeling the pathway to predict ruminal flows of unsaturated fatty acids and biohydrogenation intermediates across a range of ruminal conditions...
- Intake of unsaturated fatty acids and HDL cholesterol levels are associated with manifestations of atopy in adultsT Schafer
Department of Social Medicine, University Lübeck, Germany
Clin Exp Allergy 33:1360-7. 2003The increase in allergic diseases is still unexplained. It was hypothesized that the intake of unsaturated fatty acids is a contributing cause of this development...
- NMR and quantum chemical study on the OH...pi and CH...O interactions between trehalose and unsaturated fatty acids: implication for the mechanism of antioxidant function of trehaloseKazuyuki Oku
Amase Institute, Hayashibara Biochemical Laboratories, Inc, 7 7 Amaseminami machi, Okayama 700 0834, Japan
J Am Chem Soc 125:12739-48. 2003..Therefore, trehalose has a significant depression effect on the oxidation of UFA through the weak interaction with the double bond(s). This is the first study to elucidate the antioxidant function of trehalose...
- [Unsaturated fatty acids intake and breast cancer risk: epidemiological data review]Anne C M Thiebaut
Equipe E3N EPIC, INSERM, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex
Bull Cancer 92:658-69. 2005..However, it is difficult in human to disentangle the effect of nutrient intake from that of contributing foods or even nutritional profile...
- Metabolic fate of long-chain unsaturated fatty acids and their effects on palmitic acid metabolism and gluconeogenesis in bovine hepatocytesD G Mashek
Department of Dairy Science, University of Wisconsin, Madison 53706, USA
J Dairy Sci 85:2283-9. 2002..The unsaturated fatty acids also influenced palmitic acid metabolism...
- Metabolism and functions of highly unsaturated fatty acids: an updateM T Nakamura
Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
Lipids 36:961-4. 2001..This review briefly examines the recent progress in knowledge about the synthesis and degradation of highly unsaturated fatty acids (HUFA) and their functions...
- The "albumin effect" and in vitro-in vivo extrapolation: sequestration of long-chain unsaturated fatty acids enhances phenytoin hydroxylation by human liver microsomal and recombinant cytochrome P450 2C9Andrew Rowland
Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, SA 5042, Australia
Drug Metab Dispos 36:870-7. 2008..The results indicate that previously determined in vitro K(m) values for CYP2C9 substrates are almost certainly overestimates, and accurate in vitro-in vivo extrapolation of kinetic data for CYP2C9 substrates is achievable...
- Plant oxylipins: plant responses to 12-oxo-phytodienoic acid are governed by its specific structural and functional propertiesChristine Böttcher
CSIRO Plant Industry, Adelaide, Australia
FEBS J 276:4693-704. 2009..In this context, aspects such as the differential recruitment of OPDA, either by de novo biosynthesis or by release from cyclo-oxylipin-galactolipids, and the conjugation of free OPDA are discussed...
- Oxidation decomposition of unsaturated fatty acids by singlet oxygen in phospholipid bilayer membranesNaoki Watabe
Faculty of Biomedical Engineering, Toin University of Yokohama, Yokohama, Japan
J Oleo Sci 56:73-80. 2007Oxidation decomposition of unsaturated fatty acids with singlet oxygen generated from a photosensitizing agent was investigated in liposome bilayer membranes under a light irradiation condition...
- Effect of in vitro docosahexaenoic acid supplementation to marine algae-adapted and unadapted rumen inoculum on the biohydrogenation of unsaturated fatty acids in freeze-dried grassB Vlaeminck
Laboratory for Animal Nutrition and Animal Product Quality, Ghent University, Proefhoevestraat 10, 9090 Melle, Belgium
J Dairy Sci 91:1122-32. 2008....
- Changes in Na+/K+-ATPase activity, unsaturated fatty acids and metallothioneins in gills of the shore crab Carcinus aestuarii after dilute seawater acclimationC Lucu
Center for Marine Research, Ruder Boskovic Institute, 52210 Rovinj, Croatia
Comp Biochem Physiol A Mol Integr Physiol 149:362-72. 2008..Assuming an antioxidant role of MT associated with intracellular zinc partitioning, the observed MT induction in posterior gills may be considered an adaptive response of C. aestuarii to hyposmotic stress...
- Role of SCD1 and Dietary Methionine Restriction on Energy HomeostasisERIC PAUL PLAISANCE; Fiscal Year: 2011..is increased in obesity and catalyzes the conversion of saturated fatty acids (16:0 and 18:0) to mono- unsaturated fatty acids (16:1 and 18:1)...
- REGULATION OF GENE EXPRESSION BY DIETARY FATLisa M Salati; Fiscal Year: 2012..This project will provide important new data on the ways in which dietary fat can regulate intracellular metabolism. ..
- PUFA Synthesis and the Control of Hepatic MetabolismDonald B Jump; Fiscal Year: 2013..Defining the mechanistic linkage between PUFA synthesis, TAG hydrolysis, FoxO1, GNG &stress pathways will identify novel methods to manage diabetic complications, like hyperglycemia &fatty liver. ..
- Dietary Lipids and Silica-Accelerated AutoimmunityJames J Pestka; Fiscal Year: 2013..Finally, it is expected that these studies will reveal additional potential benefits of n-3 PUFA consumption on silica-induced lung disease and fibrosis, another understudied area. ..
- Role of ALDH7A1 in Ethanol-Induced Oxidative DamageCHAD NICHOLAS BROCKER; Fiscal Year: 2011..This long term goal of this project is to elucidate the protective functions of ALDH7A1 during excessive alcohol consumption. ..
- Metabolic Actions of Omega-3 Fatty Acids on InflammationMichael Miller; Fiscal Year: 2013..Favorable outcomes from this study could translate into a new approach to improve heart disease risk in men and women with the metabolic syndrome. ..
- Role of NPC1L1 in regulating energy metabolism, nutrient utilization & weight gaiPhilip N Howles; Fiscal Year: 2010..inhibiting cholesterol absorption reduces saturated fatty acid absorption without affecting absorption of unsaturated fatty acids. In vitro, cell culture, and in vivo experiments will test the hypothesis that unabsorbed cholesterol ..
- Fatty Acid Defects &Oxidative Stress Modulate Islet Function in Cystic FibrosisAliye Uc; Fiscal Year: 2013..The long-term goal is to develop improved therapies to prevent the insulin secretory defects in CF and the progression to CFRD. ..
- Prevention of high fat diet-induced vascular injuryMing Hui Zou; Fiscal Year: 2013..It is anticipated that the completion of this project will yield important insights into how omega-3 polyunsaturated fatty acids protect against cardiovascular diseases. ..
- NKT cells, fatty acids, and insulin resistanceCURTIS LEE GABRIEL; Fiscal Year: 2010..free fatty acids by using an in vitro model of indirect NKT cell activation and a panel of saturated and unsaturated fatty acids. Our second aim will investigate how NKT cell activity is influenced by specific diets...
- The Role of Cyp2b in Toxicant Metabolism and SensitivityWilliam S Baldwin; Fiscal Year: 2012..oil as a carrier revealed that Cyp2b-KD mice but not wild-type mice are unable to properly depurate the unsaturated fatty acids from the liver. This suggests an important role for Cyp2b in lipid homeostasis...
- Fatty acid Control Obesity and the Metabolic Syndrome via TPR proteinsTerry D Hinds; Fiscal Year: 2010..Factors that control obesity via dietary intake or supplemental control are of much interest. Unsaturated fatty acids, especially polyunsaturated fatty acids, have been shown in clinical and animal studies to be useful in ..
- Molecular Mechanisms of Mitigation of Insulin Induction of SREBP-1c by N-3 PUFAMarshall B Elam; Fiscal Year: 2013..We are examining the ability of highly unsaturated fatty acids (Polyunsaturated Fatty Acids or PUFA) derived from fish oil to reduce fat production in the liver by ..
- Fatty acid desaturase activity, fish oil and colorectal cancer chemopreventionHarvey J Murff; Fiscal Year: 2013..We anticipate that fish oil will have anti-neoplastic effect and individuals with low FADS1 activity will have a greater response compared to individuals with high FADS1 activity. ..
- RESEARCH CENTER FOR PHARMACOLOGY AND DRUG TOXICOLOGYL Jackson Roberts; Fiscal Year: 2010..It is anticipated that the projects proposed will significantly advance our understanding of the pharmacology and biology of eicosanoids and related compounds. ..
- Alterations in membrane composition and function eith calorie restrictionJon J Ramsey; Fiscal Year: 2011..Also, NAD(P)H-quinone reductase knockout (NQO1 KO) mice will be used to determine if stimulation of the PM redox system is required for life span extension with CR. ..
- SECOND MESSENGERS IN THE RETINARAJU VS RAJALA; Fiscal Year: 2012..Our long-term goal is to understand these mechanisms as a foundation on which novel drug therapies can be designed to protect retinal function in patients who suffer from retinal degenerations. ..
- Colonic Cytokinetics and Cell Signaling: Dietary EffectsROBERT STEPHEN CHAPKIN; Fiscal Year: 2012....
- Obesity related pancreatic fat worsens local injury via unsaturated fatty acidsVIJAY PREM SINGH; Fiscal Year: 2013..We therefore hypothesize that obesity-associated intrapancreatic fat worsens pancreatic injury via unsaturated fatty acids generated from local lipolysis...
- Tumor -Targeting Chemotherapeutic AgentsIwao Ojima; Fiscal Year: 2013..This proposal deals with novel tumor-targeting drug delivery systems to address these urgent medical issues. ..
- The altered lipid and protein metabolism of pediatric patients with HIV infectionFarook Jahoor; Fiscal Year: 2010..of high density lipoprotein apoprotein Al (HDL-apoAl), 3) a lower fat diet rich in poly and mono- unsaturated fatty acids will improve the hypertriglyceridemia and hypercholesterolemia of HIV-infected dyslipidemic subjects...
- Obesity, Biomechanics, and Inflammation in OsteoarthritisFarshid Guilak; Fiscal Year: 2013..mice fed high-fat diets high in saturated and monounsaturated fatty acids, or omega-3 or omega-6 poly-unsaturated fatty acids. In Aim 2, we will examine the effects of obesity (via high-fat diet or leptin deficiency) and weight ..
- Effects of insulin on the microvasculatureEUGENE JOSEPH BARRETT; Fiscal Year: 2013....
- Human CYP1A1, diet and dioxin-induced hypertensionMary K Walker; Fiscal Year: 2012....
- The role of phosphorylation in regulating the antidiabetic effects of O3FAR-1Nader H Moniri; Fiscal Year: 2013..to as GPR120, is a G protein-coupled receptor (GPCR) that has been shown to be agonized by long chained unsaturated fatty acids, specifically, those belonging to the omega-3 fatty acid (O3FA) family...
- LIPID MODULATION OF RHODOPSIN SIGNALING IN MEMBRANESMichael F Brown; Fiscal Year: 2010..This work is pertinent to the role of polyunsaturated lipids in the function and dysfunction of central nervous system of humans with attendant insights that may be of eventual therapeutic benefit. ..
- Omega-3 PUFA suppress adipochemokines in human obesityRachana Shah; Fiscal Year: 2013....
- CNS PPAR gamma and energy homeostasisHEIDI E KOCALIS; Fiscal Year: 2011..If a role for PPARy in CNS controlled energy homeostasis is indicated, this will establish the brain as yet another target of PPARy agonist drugs. ..
- Southern Community Cohort StudyWei Zheng; Fiscal Year: 2013..abstract_text> ..
- Role of Astrocytic TREK-2 Potassium Channels in Cerebral IschemiaMisty J Eaton; Fiscal Year: 2013....
- MEMBRANE BASIS OF VISUAL EXCITATIONMichael F Brown; Fiscal Year: 2012..Understanding the protein and lipid components of visual membranes is vitally significant to the prevention of human diseases. ..
- Mitochondrial Bioenergetic Dysfunction and Chlorine ToxicitySadis Matalon; Fiscal Year: 2013..are depleted, it fors relatively stable adducts with proteins, components of the extracellular matrix and unsaturated fatty acids which then proceed to prolong the toxicity of the initial Cl2 exposure and contribute t the long term ..
- Dietary Fat in Ethanol-Induced Intestinal Barrier Dysfunction in ALDIrina Kirpich; Fiscal Year: 2013..Dietary modulation may represent a novel preventive/therapeutic approach in ALD, and MLCK could be a specific novel therapeutic target. ..
- PAF Receptor Trafficking and Function in Epithelial CellsTamas Jilling; Fiscal Year: 2010..These studies will elucidate the mechanisms of PAFR targeting in epithelial cells, and a novel mechanism by which PUFA might affect the function of PAFR, and other GPCR-s. ..
- Established Investigator Award Anti-Inflammatory Exposures in Cancer PreventionEmily White; Fiscal Year: 2013..To accomplish this, the applicant will reduce her large administrative responsibilities, including stepping down from her role as Associate Dean for Research in the University of Washington School of Public Health. ..
- Functional Analysis of MGAT EnzymesRobert V Farese; Fiscal Year: 2010..Additionally, if MGAT2 deficiency protects against diet-induced obesity, it may also protect against diet-induced insulin resistance and type 2 diabetes. ..
- GENETIC DISSECTION OF PHOTOTRANSDUCTIONBaruch Minke; Fiscal Year: 2011..Therefore, studies on Drosophila TRP and TRPL channels are likely to be relevant for understanding retinal degeneration and mechanisms underlying the damage to RGC by glaucoma. ..
- Genetic Approaches to Lipid MetabolismJohn E Cronan; Fiscal Year: 2013..A second focus will be on the mechanisms of synthesis of unsaturated fatty acids, an essential component of the membrane lipids of most bacteria...
- MOLECULAR REGULATION OF APOPROTEIN B DEGRADATIONEdward A Fisher; Fiscal Year: 2012..abstract_text> ..
- Maternal Diet and Susceptibility to Neonatal Brain InjuryJohn D Barks; Fiscal Year: 2013..S. population. ..
- Regulation of Mitochondrial Dysfunction and Diet-Induced Obesity by ALCAT1Yuguang Shi; Fiscal Year: 2012....
- Effect of Nutritional Factors on Macrophage Accumulation in Adipose TissueAlan Chait; Fiscal Year: 2012..abstract_text> ..
- FUNCTION AND REGULATION OF GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 2MARIA R GONZALEZ BARO; Fiscal Year: 2012....
- Stress, Mood, Omega-3 Fatty Acids, &Telomeric Aging: Randomized Controlled TrialJanice K Kiecolt-Glaser; Fiscal Year: 2012..By adding cell aging assessments to an ongoing randomized controlled trial of omega-3 supplementation, we can assess how omega-3 supplementation affects both telomerase activity and telomere length, as well as possible mechanisms. ..
- Mechanisms by which Obesity in Pregnancy Leads to Obesity in OffspringRebecca A Simmons; Fiscal Year: 2013..Since the incidence of obesity is rapidly increasing in the United States, these studies will have great impact on health. ..
- Protective Effects of Fatty Acids in Phthalate-Induced Inflammation in NeonatesANNA MARIE VETRANO; Fiscal Year: 2013..These findings will address this need, and may suggest novel nutritional interventions to prevent chronic inflammatory conditions associated with exposure to phthalates in neonates. ..
- N-3 Fatty Acid-Induced Akt Suppression: Chemoprevention for Pancreatic NeoplasiaPAUL JOSEPH GRIPPO; Fiscal Year: 2013....
- Lipid electrophile adduction of Pin1 and effects on substrate binding &activityChristopher D Aluise; Fiscal Year: 2013..The proposed research allows for significant insight into the cellular response to Pin1 protein modification as a consequence of lipid peroxidation. ..
- Molecular mechanism of omega-3 responseJAMES T BRENNA; Fiscal Year: 2013..Human genetic variation and metabolic conditions responsive to omega-3 LCPUFA supplementation will be identified. ..
- Genetics of Obesity in Yup'ik EskimosBERT BRANDON BOYER; Fiscal Year: 2011..abstract_text> ..
- Prostaglandins in C. elegans FertilizationMichael A Miller; Fiscal Year: 2013..Regardless, basic research on prostaglandins in the C. elegans gonad has the potential for discovering molecular mechanisms of human infertility, contraception, and cancer. ..
- Formation of Omega 3-Derived Electrophiles During InflammationFRANCISCO JOSE SCHOPFER; Fiscal Year: 2013..It is expected that this proposal will lead to a better understanding of w-3 fatty acid effects and to improved pharmacological approaches to decrease atherosclerosis and its detrimental effects. ..
- Stress and Proinflammatory Cytokines: Omega-3 InterventionJanice Kiecolt Glaser; Fiscal Year: 2009....
- Metabolic requirements of adult neural stem cellsPhilip J Horner; Fiscal Year: 2012..We hope to impact public health by identifying mechanisms underlying behavior-induced changes in cellular activity, especially in cells capable of regeneration within the adult and aging brain. ..
- Naturally Occurring Lipid Mediators Enhance Antibody ProductionRichard P Phipps; Fiscal Year: 2013..The stimulatory properties of SPM will be further assessed by challenging immunized mice with live influenza viral strains, including the 2009 H1N1, and monitoring weight loss, survival, and viral titers. ..
- Nitro-Fatty Acids and Nrf2 in Vascular RemodelingYuqing Eugene Chen; Fiscal Year: 2013..NO) and ROS, react with carbohydrates, DNA bases, protein tyrosine/tryptophan, and unsaturated fatty acids to form relatively stable nitrated products...
- Neuroimaging of Fatty Acids in Major DepressionM Elizabeth Sublette; Fiscal Year: 2012..This study is expected to contribute to understanding the neurobiology of depression and may provide new information relevant to treatment with dietary fatty acids. ..
- The Wake Forest Center for Botanical Lipids and Inflammatory Disease PreventionFloyd H Chilton; Fiscal Year: 2013..The central hypothesis of the Center is that medium chain poly-unsaturated fatty acids (PUFAs) in botanical oils and their metabolites impact several key mechanisms (including altering pro-and ..
- Understanding the influence of n-3 PUFA on pro-inflammatory aspects of mercuryAllen J Rosenspire; Fiscal Year: 2013..Both in vitro and in vivo models will be employed, where the plan is to utilize western blotting techniques, as well as flow cytometric-based technology to map CD95 signaling networks. ..
- GLUTAMATE-GATED CHANNELS IN CENTRAL &PERIPHERAL NEURONSJames E Huettner; Fiscal Year: 2013..pore loop and adjacent transmembrane helices govern kainate receptor susceptibility to inhibition by cis-unsaturated fatty acids, such as docosahexaenoic acid (DHA)...
- Non-pharmacological control of atherosclerosisSampath Parthasarathy; Fiscal Year: 2013..Sesame oil contains equal amounts of mono- and poly unsaturated fatty acids and contains bio-active non-saponifiable components that are potent antioxidants and PPAR1 agonists...
- Lipid Mediators of Insulin ResistanceScott A Summers; Fiscal Year: 2012..Aim Two: Phosphatidic acid, and not diacyglycerol, links unsaturated fatty acids to the induction of insulin resistance through the target protein mTOR...
- DIETARY LIPIDS--EFFECTS ON LIPID-LIPOPROTEIN METABOLISMD Illingworth; Fiscal Year: 1991..Overall, these studies should enhance our knowledge concerning the clinical and metabolic effects of specific dietary lipids and have direct therapeutic application to treatment of subjects with hypercholesterolemia...
- Pilot Study on Mammary Expression of Novel DesaturasesALISON VAN EENENNAAM; Fiscal Year: 2005....
- POLYUNSATURATES AND KC1 TO CONTROL MILD HYPERTENSIONFrank Sacks; Fiscal Year: 1991..Biochemical validation of compliance with each treatment will be obtained. The discovery of an effective dietary supplement to treat mild hypertension would be of great interest and practical importance...
- EFFECTS OF POLYUNSATURATED FATTY ACIDS ON MEGAKARYOCYTESPAUL SCHICK; Fiscal Year: 1991..on the lipid composition, desaturase activity, and the uptake and transfer of arachidonic acid and other unsaturated fatty acids will be determined...
- Refinement of LC/ESR/MS for Studying Lipid Free Radicals in Colon Cancer GrowthSteven Qian; Fiscal Year: 2009..We anticipate that the outcome of our research will open a new door into knowledge of PUFA peroxidation in cancer biology and will revolutionize how we use our knowledge of enzymatic peroxidation to control colon cancer. ..
- DIETARY N-3 FATTY ACIDS: TRANSPORT AND UPTAKE INTO BRAINGregory Anderson; Fiscal Year: 1993....
- Regulation of syndecan 1 in by n-3 PUFAIRIS EDWARDS; Fiscal Year: 2009..abstract_text> ..
- Prevention of Post-Prandial Hypoglycemia Using n-3/n-6 PUFA in PCOSSIDIKA KARAKAS; Fiscal Year: 2009..Our aim is to identify the best supplement that can prevent hypoglycemia and its unwanted consequences in these young women-an under-studied patient population. ..
- ALTERED MEMBRANE PHOSPHOLIPIDS AND CARDIAC FUNCTIONDIANE REIBEL; Fiscal Year: 1990..The proposed studies will further our understanding of the effects of dietary fish oil on cardiac function and the pathogenesis of myocardial ischemia...
- NUTRITIONAL SIGNIFICANCE OF POLYUNSATURATED FATTY ACIDSVincent Ziboh; Fiscal Year: 1990..Taken together, these studies should provide information on the dietary role of each of the PUFA on 14C-AA metabolism by epidermis and PMNs as well as on PMNs function...
- OMEGA-3 FATTY ACIDS IN NORMAL VISUAL DEVELOPMENTEileen Birch; Fiscal Year: 2003..By relating long-term outcomes to visual cortical function during infancy, we will directly evaluate the predictive of early visual tests for long-term cognitive outcomes. ..