unsaturated fatty acids

Summary

Summary: FATTY ACIDS in which the carbon chain contains one or more double or triple carbon-carbon bonds.

Top Publications

  1. pmc Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region
    N Kudo
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Proc Natl Acad Sci U S A 96:9112-7. 1999
  2. pmc Protein ligands to HuR modulate its interaction with target mRNAs in vivo
    C M Brennan
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Cell Biol 151:1-14. 2000
  3. ncbi Cardiovascular disease risk of dietary stearic acid compared with trans, other saturated, and unsaturated fatty acids: a systematic review
    J Edward Hunter
    Department of Chemistry University of Cincinnati Cincinnati OH 45221 0172, USA
    Am J Clin Nutr 91:46-63. 2010
  4. ncbi CRM1 is an export receptor for leucine-rich nuclear export signals
    M Fornerod
    European Molecular Biology Laboratory, Heidelberg, Germany
    Cell 90:1051-60. 1997
  5. ncbi Stimulation of mitochondrial reactive oxygen species production by unesterified, unsaturated fatty acids in defective human spermatozoa
    Adam J Koppers
    Discipline of Biological Sciences and ARC Centre of Excellence in Biotechnology and Development, Faculty of Science and IT, University of Newcastle, Callaghan, NSW 2308, Australia
    Free Radic Biol Med 48:112-9. 2010
  6. ncbi PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism
    Manlio Vinciguerra
    Department of Cell Physiology and Metabolism, Geneva Medical Faculty, Geneva University Hospital, Switzerland
    Gastroenterology 134:268-80. 2008
  7. ncbi Fatty acid synthesis is a target for antibacterial activity of unsaturated fatty acids
    Chang Ji Zheng
    Korea Research Institute of Bioscience and Biotechnology, P O Box 115, Yusong, Daejeon 305 600, Republic of Korea
    FEBS Lett 579:5157-62. 2005
  8. ncbi Polyunsaturated fatty acid regulation of genes of lipid metabolism
    Harini Sampath
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Annu Rev Nutr 25:317-40. 2005
  9. ncbi Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a phospholipase D2 pathway
    Yutong Wang
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 280:35896-903. 2005
  10. pmc RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channels
    Niels Decher
    Institut fur Physiologie und Pathophysiologie, Universitat Marburg, Marburg, Germany
    EMBO J 29:2101-13. 2010

Detail Information

Publications296 found, 100 shown here

  1. pmc Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region
    N Kudo
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Proc Natl Acad Sci U S A 96:9112-7. 1999
    ..These results show that the single cysteine residue determines LMB sensitivity and is selectively alkylated by LMB, leading to CRM1 inactivation...
  2. pmc Protein ligands to HuR modulate its interaction with target mRNAs in vivo
    C M Brennan
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Cell Biol 151:1-14. 2000
    ..We discuss the possible role of these ligands upstream of HuR in pathways that govern the stability of ARE-containing mRNAs...
  3. ncbi Cardiovascular disease risk of dietary stearic acid compared with trans, other saturated, and unsaturated fatty acids: a systematic review
    J Edward Hunter
    Department of Chemistry University of Cincinnati Cincinnati OH 45221 0172, USA
    Am J Clin Nutr 91:46-63. 2010
    ..High stearic acid (STA) soybean oil is a trans-free, oxidatively stable, non-LDL-cholesterol-raising oil that can be used to replace trans fatty acids (TFAs) in solid fat applications...
  4. ncbi CRM1 is an export receptor for leucine-rich nuclear export signals
    M Fornerod
    European Molecular Biology Laboratory, Heidelberg, Germany
    Cell 90:1051-60. 1997
    ..We conclude that CRM1 is an export receptor for leucine-rich nuclear export signals and discuss a model for the role of RanGTP in CRM1 function and in nuclear export in general...
  5. ncbi Stimulation of mitochondrial reactive oxygen species production by unesterified, unsaturated fatty acids in defective human spermatozoa
    Adam J Koppers
    Discipline of Biological Sciences and ARC Centre of Excellence in Biotechnology and Development, Faculty of Science and IT, University of Newcastle, Callaghan, NSW 2308, Australia
    Free Radic Biol Med 48:112-9. 2010
    ..001). This relationship was causal and mediated by the range of unesterified, unsaturated fatty acids that are present in human spermatozoa...
  6. ncbi PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism
    Manlio Vinciguerra
    Department of Cell Physiology and Metabolism, Geneva Medical Faculty, Geneva University Hospital, Switzerland
    Gastroenterology 134:268-80. 2008
    ..Here, we investigated the pathophysiologic mechanisms regulating PTEN expression in the liver and the development of steatosis...
  7. ncbi Fatty acid synthesis is a target for antibacterial activity of unsaturated fatty acids
    Chang Ji Zheng
    Korea Research Institute of Bioscience and Biotechnology, P O Box 115, Yusong, Daejeon 305 600, Republic of Korea
    FEBS Lett 579:5157-62. 2005
    Long-chain unsaturated fatty acids, such as linoleic acid, show antibacterial activity and are the key ingredients of antimicrobial food additives and some antibacterial herbs...
  8. ncbi Polyunsaturated fatty acid regulation of genes of lipid metabolism
    Harini Sampath
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Annu Rev Nutr 25:317-40. 2005
    ..Working out the mechanisms by which these interactions and consequent effects occur is proving to be complicated but is invaluable to our understanding of the role that dietary fat can play in disease management and prevention...
  9. ncbi Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a phospholipase D2 pathway
    Yutong Wang
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 280:35896-903. 2005
    ..b>Unsaturated fatty acids, which are elevated in diabetes, impair the ABCA1 pathway in cultured cells by destabilizing ABCA1 ..
  10. pmc RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channels
    Niels Decher
    Institut fur Physiologie und Pathophysiologie, Universitat Marburg, Marburg, Germany
    EMBO J 29:2101-13. 2010
    ..x channels. Our findings provide a mechanistic understanding of lipid-induced inactivation and establish RNA editing as a mechanism to induce drug and lipid resistance in Kv channels...
  11. ncbi Different role of saturated and unsaturated fatty acids in beta-cell apoptosis
    Katrin Eitel
    Internal Medicine IV, University of Tubingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
    Biochem Biophys Res Commun 299:853-6. 2002
    ..Cells were incubated for 24-72 h with 1mM fatty acids. All unsaturated fatty acids tested completely prevented palmitate- or stearate-induced apoptosis of rat and human beta-cells as ..
  12. pmc Myristoylation as a target for inhibiting HIV assembly: unsaturated fatty acids block viral budding
    O Wolf Lindwasser
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 143, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 99:13037-42. 2002
    ..Furthermore, treatment of cells with 14-carbon unsaturated fatty acids inhibited Gag-driven particle assembly...
  13. ncbi Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements
    Tomohiro Yoshikawa
    Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Biol Chem 277:1705-11. 2002
    ..acid > eicosapentaenoic acid > docosahexaenoic acid > linoleic acid), whereas saturated or mono-unsaturated fatty acids had minimal effects...
  14. ncbi Endothelial lipase releases saturated and unsaturated fatty acids of high density lipoprotein phosphatidylcholine
    M Gauster
    Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University Graz, Harrachgasse 21 III, Graz A 8010, Austria
    J Lipid Res 46:1517-25. 2005
    ....
  15. ncbi A bifunctional Delta12,Delta15-desaturase from Acanthamoeba castellanii directs the synthesis of highly unusual n-1 series unsaturated fatty acids
    Olga Sayanova
    Rothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, United Kingdom
    J Biol Chem 281:36533-41. 2006
    ..The presence of a bifunctional Delta12,Delta15-desaturase in A. castellanii is also considered with reference to the evolution of desaturases and the lineage of this protist...
  16. ncbi Bio-markers of lipid peroxidation in vivo: hydroxyoctadecadienoic acid and hydroxycholesterol
    Yasukazu Yoshida
    National Institute of Advanced Industrial Science and Technology AIST, Human Stress Signal Research Center, 1 8 31 Midorigaoka, Ikeda 563 8577, Japan
    Biofactors 27:195-202. 2006
    ..In addition to this advantage, hydrogen-donor activity of antioxidants in vivo could be determined by the isomeric-ratio of HODE (9- and 13-(Z,E)-HODE/9- and 13-(E,E)-HODE)...
  17. ncbi Krabbe disease: psychosine-mediated activation of phospholipase A2 in oligodendrocyte cell death
    S Giri
    Department of Pediatrics, Charles P Darby Children s Research Institute, Medical University of South Carolina, Charleston, 29425, USA
    J Lipid Res 47:1478-92. 2006
    ....
  18. ncbi Fatty acid elongases in mammals: their regulation and roles in metabolism
    Andreas Jakobsson
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 10691 Stockholm, Sweden
    Prog Lipid Res 45:237-49. 2006
    ..We will consider both the biochemical functions of the proteins, as well as their role in a more physiological context...
  19. ncbi Unsaturated fatty acids inhibit cholesterol efflux from macrophages by increasing degradation of ATP-binding cassette transporter A1
    Yutong Wang
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 277:5692-7. 2002
    ..Results showed that unsaturated fatty acids markedly inhibited ABCA1-mediated cholesterol and phospholipid efflux from macrophages when ABCA1 was ..
  20. pmc Induction of the Arabidopsis PHO1;H10 gene by 12-oxo-phytodienoic acid but not jasmonic acid via a CORONATINE INSENSITIVE1-dependent pathway
    Cecile Ribot
    Département de Biologie Moléculaire Végétale, Biophore, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    Plant Physiol 147:696-706. 2008
    ..Furthermore, the implication of the ABA pathway in coregulating AtPHO1;H10 expression is dependent on the abiotic stress applied, being weak under wounding but strong upon dehydration...
  21. ncbi Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4
    J Y Lee
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 276:16683-9. 2001
    ..7). Results show that SFAs, but not unsaturated fatty acids (UFAs), induce nuclear factor kappaB activation and expression of COX-2 and other inflammatory markers...
  22. ncbi The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic beta-cells
    Noel G Morgan
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Plymouth PL6 8BU, UK
    Biochem Soc Trans 36:905-8. 2008
    ..However, when incubated in vitro, beta-cells respond differentially to long-chain saturated and mono-unsaturated fatty acids, suggesting that these molecules may regulate cell functionality by different mechanisms...
  23. ncbi Production of polyunsaturated fatty acids by polyketide synthases in both prokaryotes and eukaryotes
    J G Metz
    Omega Tech, 4909 Nautilus Court North, Boulder, CO 80301 3242, USA
    Science 293:290-3. 2001
    ..It is likely that PUFA synthesis in cold marine ecosystems is accomplished in part by these PKS enzymes...
  24. ncbi Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease
    Frederic Calon
    Department of Medicine, University of California, Los Angeles, California, USA
    Eur J Neurosci 22:617-26. 2005
    ..The marked effect of dietary n-3 PFA on NMDA receptors and caspase/calpain activation in the cortex of an animal model of AD provide new insights into how dietary essential fatty acids may influence cognition and AD risk...
  25. pmc The role of n-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary n-3 fatty acids
    Klara Kitajka
    Institute of Biochemistry, and DNA Chip Laboratory, Biological Research Center, Hungarian Academy of Sciences, P O Box 521, H 6701 Szeged, Hungary
    Proc Natl Acad Sci U S A 99:2619-24. 2002
    ....
  26. ncbi Juvenoid hormone methyl farnesoate is a sex determinant in the crustacean Daphnia magna
    Allen W Olmstead
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695 7633, USA
    J Exp Zool 293:736-9. 2002
    ..These results demonstrate that methyl farnesoate is capable of programming daphnid embryos to develop into males and is likely the endocrine factor responsible for initiating the sexual reproductive phase in these organisms...
  27. ncbi Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation
    Song Hong
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:14677-87. 2003
    ..These results indicate that DHA is the precursor to potent protective mediators generated via enzymatic oxygenations to novel docosatrienes and 17S series resolvins that each regulate events of interest in inflammation and resolution...
  28. ncbi Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN
    Manlio Vinciguerra
    Department of Cellular Physiology and Metabolism, Faculty of Medicine, University of Geneva, CMU, 1 rue Michel Servet, 1211 Geneva, Switzerland
    J Hepatol 50:1132-41. 2009
    ..We recently demonstrated that unsaturated fatty acids trigger the downregulation of the tumor suppressor PTEN through an mTOR/NF-kappaB-dependent mechanism in ..
  29. ncbi Is obesity an inflammatory condition?
    U N Das
    EFA Sciences LLC, Norwood, Massachusets 02062, USA
    Nutrition 17:953-66. 2001
    ....
  30. pmc Plant defense in the absence of jasmonic acid: the role of cyclopentenones
    A Stintzi
    Institute of Biological Chemistry, Washington State University, Pullman, WA 99164-6340, USA
    Proc Natl Acad Sci U S A 98:12837-42. 2001
    ..More generally, resistance to insect and fungal attack can be observed in the absence of JA...
  31. ncbi Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials
    Ronald P Mensink
    Department of Human Biology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 77:1146-55. 2003
    ..Fats, however, also affect HDL cholesterol, and the ratio of total to HDL cholesterol is a more specific marker of CAD than is LDL cholesterol...
  32. ncbi Docosahexaenoic acid promotes neurite growth in hippocampal neurons
    Frances Calderon
    Section of Mass Spectrometry, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    J Neurochem 90:979-88. 2004
    ..Our data demonstrates that DHA uniquely promotes neurite growth in hippocampal neurons. Inadequate neurite development due to DHA deficiency may contribute to the cognitive impairment associated with n-3 fatty acid deficiency...
  33. ncbi Roles of unsaturated fatty acids (especially omega-3 fatty acids) in the brain at various ages and during ageing
    J M Bourre
    INSERM Research Director Unit U26 Neuro pharmaco nutrition Hopital Fernand Widal, 200 rue du Faubourg Saint Denis 75745 Paris cedex 10
    J Nutr Health Aging 8:163-74. 2004
    ..Peroxisomal oxidation of polyunsaturated fatty acids decreases in the brain during ageing, participating in decreased turnover of membrane fatty acids, which are also less effectively protected against peroxidation by free radicals...
  34. ncbi Nucleocytoplasmic shuttling of the thyroid hormone receptor alpha
    C F Bunn
    Department of Zoology, University of Canterbury, Christchurch, New Zealand 8001
    Mol Endocrinol 15:512-33. 2001
    ..Acquisition of altered nuclear export capabilities may contribute to the oncogenic properties of v-ErbA...
  35. ncbi Novel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectins
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Clin Nutr Metab Care 8:115-21. 2005
    ..Many clinical studies suggest that omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid have beneficial actions in human diseases. The molecular basis of these actions remains of interest...
  36. ncbi Suppression of ABCA1 by unsaturated fatty acids leads to lipid accumulation in HepG2 cells
    Yanhong Yang
    Department of Cell Biology, Municipal Laboratory for Liver Protection and Regulation of Regeneration, Capital Medical University, Beijing 100069, China
    Biochimie 92:958-63. 2010
    ..We previously reported that unsaturated fatty acids destabilise ABCA1 in murine macrophages and ABCA1-transfected baby hamster kidney cells by increasing its ..
  37. ncbi Altered fatty acid compositions in atlantic salmon (Salmo salar) fed diets containing linseed and rapeseed oils can be partially restored by a subsequent fish oil finishing diet
    J Gordon Bell
    Institute of Aquaculture, University of Stirling, Stirling, FK9 4LA, Scotland, UK
    J Nutr 133:2793-801. 2003
    ..Inclusion of vegetable oil at 33% of total oil significantly reduced the concentrations of the highly unsaturated fatty acids, eicosapentaenoate [20:5(n-3)] and docosahexaenoate [22:6(n-3)], to approximately 70 and 75%, ..
  38. pmc Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock
    I E Gallouzi
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    RNA 7:1348-61. 2001
    ..HuR and its ligands may be instrumental in the nuclear export of heat-shock mRNAs...
  39. ncbi Cis-unsaturated fatty acids stimulate reactive oxygen species generation and lipid peroxidation in human spermatozoa
    R John Aitken
    Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    J Clin Endocrinol Metab 91:4154-63. 2006
    ..there are also data indicating that defective human spermatozoa contain abnormally high amounts of cis-unsaturated fatty acids. This study investigated whether a causative relationship exists between these two attributes of impaired ..
  40. pmc Calreticulin Is a receptor for nuclear export
    J M Holaska
    Center for Cell Signaling, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Cell Biol 152:127-40. 2001
    ..CRT defines a new export pathway that may regulate the transcriptional activity of steroid hormone receptors...
  41. ncbi Dyslipidemia, but not hyperglycemia, induces inflammatory adhesion molecules in human retinal vascular endothelial cells
    Weiqin Chen
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824, USA
    Invest Ophthalmol Vis Sci 44:5016-22. 2003
    ..The purpose of this study was to examine the effect of fatty acids and hyperglycemia on human retinal vascular endothelial (hRVE) cells as a means of mimicking diabetic metabolic disorders...
  42. ncbi Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation
    M Itoh
    First Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, 060 8543, Japan
    Mol Endocrinol 16:2382-92. 2002
    ..Taken together, these findings suggest that JNK-mediated phosphorylation of the GR-Ser226 enhances GR nuclear export and may contribute to termination of GR-mediated transcription...
  43. ncbi Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies
    H Tapiero
    UNIVERSITE DE PARIS, Faculté de Pharmacie CNRS UMR 8612, Chatenay Malabry, France
    Biomed Pharmacother 56:215-22. 2002
    ....
  44. pmc A novel tetratricopeptide repeat (TPR) containing PP5 serine/threonine protein phosphatase in the malaria parasite, Plasmodium falciparum
    S Dobson
    Department of Biochemistry and Molecular Biology, University of South Alabama, College of Medicine, 307 University Blvd, Mobile, Alabama 36688 0002, USA
    BMC Microbiol 1:31. 2001
    ..Recent discovery of a few protein kinases and phosphatases point to a thriving reversible phosphorylation system in the parasite, although their function and regulation need to be determined...
  45. ncbi Lipid peroxidation and the thiobarbituric acid assay: standardization of the assay when using saturated and unsaturated fatty acids
    Leonard T Rael
    Department of Trauma Research and Trauma Services, Swedish Medical Center, 501 E Hampden Avenue, Englewood, CO 80113, USA
    J Biochem Mol Biol 37:749-52. 2004
    ..The rate of TBARS inhibition was greater for the saturated than for unsaturated fatty acids, as measured from the slope of the linear range...
  46. ncbi Evidence that unsaturated fatty acids are potent inhibitors of renal UDP-glucuronosyltransferases (UGT): kinetic studies using human kidney cortical microsomes and recombinant UGT1A9 and UGT2B7
    Paraskevi Tsoutsikos
    Department of Clinical Pharmacology, Flinders University and Flinders Medical Centre, Bedford Park, 5042, Adelaide, Australia
    Biochem Pharmacol 67:191-9. 2004
    ..It is conceivable therefore that during periods of renal ischaemia FA may impair renal drug glucuronidation thus compromising the protective capacity of the kidney against drug-induced nephrotoxicity...
  47. ncbi The cis-trans isomerase of unsaturated fatty acids in Pseudomonas and Vibrio: biochemistry, molecular biology and physiological function of a unique stress adaptive mechanism
    Hermann J Heipieper
    Department of Bioremediation, Centre for Environmental Research UFZ Leipzig Halle, Permoserstr 15, 04318 Leipzig, Germany
    FEMS Microbiol Lett 229:1-7. 2003
    Isomerization of cis to trans unsaturated fatty acids is a mechanism enabling Gram-negative bacteria belonging to the genera Pseudomonas and Vibrio to adapt to several forms of environmental stress...
  48. ncbi Unsaturated fatty acids and their oxidation products stimulate CD36 gene expression in human macrophages
    Joan Carles Vallvé
    Unitat de Recerca de Lipids i Arteriosclerosi, Facultat de Medicina, Universitat Rovira i Virgili, Sant Llorenc 21, 43201, Catalonia, Reus, Spain
    Atherosclerosis 164:45-56. 2002
    ..In contrast, DDE and HNE significantly decreased this parameter. The data provide evidence for a direct regulatory effect of UFA on CD36 gene expression and support a role for aldehydes in the regulation of CD36 expression by FA...
  49. ncbi Greater enrichment of triacylglycerol-rich lipoproteins with apolipoproteins E and C-III after meals rich in saturated fatty acids than after meals rich in unsaturated fatty acids
    Kim G Jackson
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Reading, UK
    Am J Clin Nutr 81:25-34. 2005
    ....
  50. ncbi LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1
    Yutong Wang
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 45:972-80. 2004
    ..Thus, with cholesterol-loaded macrophages exposed to saturated fatty acids, activated LXR/RXR may counteract the enhanced ABCA1 transcription by reducing the ABCA1 protein content...
  51. pmc Escherichia coli FadR positively regulates transcription of the fabB fatty acid biosynthetic gene
    J W Campbell
    Departments of Microbiologyand, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Bacteriol 183:5982-90. 2001
    ..These experiments demonstrate that expression of fabB is positively regulated by FadR...
  52. ncbi Role of nonesterified unsaturated fatty acids in the pathophysiological processes of leptospiral infection
    Patricia Burth
    Department of Cellular and Molecular Biology, Biology Institute, Universidade Federal Fluminense, Niteroi, Brazil
    J Infect Dis 191:51-7. 2005
    ..Our data support the concept that the administration of human albumin to patients may be helpful in severe leptospirosis cases...
  53. ncbi An extraordinary degree of structural specificity is required in neural phospholipids for optimal brain function: n-6 docosapentaenoic acid substitution for docosahexaenoic acid leads to a loss in spatial task performance
    Sun Young Lim
    Division of Marine Environment and Bioscience, Korea Maritime University, Busan, Korea
    J Neurochem 95:848-57. 2005
    ..In conclusion, DPAn-6 could not replace DHA for brain function, indicating a highly specific structural requirement for DHA...
  54. ncbi Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a protein kinase C delta pathway
    Yutong Wang
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 48:1062-8. 2007
    ..b>Unsaturated fatty acids, which are increased in diabetes, impair the ABCA1 pathway in cultured cells by destabilizing ABCA1 ..
  55. ncbi Unsaturated fatty acids selectively induce an inflammatory environment in human endothelial cells
    Michal Toborek
    Department of Surgery, University of Kentucky Medical Center, Lexington 40536, USA
    Am J Clin Nutr 75:119-25. 2002
    ..However, the specific effects of fatty acids on inflammatory responses in endothelial cells are not fully understood...
  56. ncbi Induction of peroxisomal proliferator-activated receptor gamma and peroxisomal proliferator-activated receptor gamma coactivator 1 by unsaturated fatty acids, retinoic acid, and carotenoids in preadipocytes obtained from bovine white adipose tissue1,2
    P García-Rojas
    Programa de Posgrado en Ciencias de la Producción y de la Salud Animal, Universidad Nacional Autonoma de Mexico, Mexico City 04510, Mexico
    J Anim Sci 88:1801-8. 2010
    ..differentiation after reaching confluence was induced by various treatments: rosiglitazone (20 microM); unsaturated fatty acids: phytanic acid (25, 50, 100 microM) and pristanic acid (25, 50, 100 microM); retinoids: 9-cis retinoic ..
  57. pmc De novo lipogenesis and stearoyl-CoA desaturase are coordinately regulated in the human adipocyte and protect against palmitate-induced cell injury
    Jennifer M Collins
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, United Kingdom
    J Biol Chem 285:6044-52. 2010
    ..DNL may not act primarily to increase fat stores but may serve as a key regulator, in tandem with elongation and desaturation, to maintain cell membrane fluidity and insulin sensitivity within the human adipocyte...
  58. ncbi Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce beta-oxidation in white fat
    P Flachs
    Department of Adipose Tissue Biology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Diabetologia 48:2365-75. 2005
    ....
  59. pmc Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step
    Joon No Lee
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 283:33772-83. 2008
    ..Here we show that unsaturated fatty acids stabilize Insig-1 without affecting its ubiquitination...
  60. ncbi Effects of dietary palmitoleic acid on plasma lipoprotein profile and aortic cholesterol accumulation are similar to those of other unsaturated fatty acids in the F1B golden Syrian hamster
    Nirupa R Matthan
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 139:215-21. 2009
    ..These data suggest that an oil relatively high in palmitoleic acid does not adversely affect plasma lipoprotein profiles or aortic cholesterol accumulation and was similar to other unsaturated fatty acid-rich oils...
  61. ncbi Effect of fatty acids on phase behavior of hydrated dipalmitoylphosphatidylcholine bilayer: saturated versus unsaturated fatty acids
    T Inoue
    Department of Chemistry, Faculty of Science, Fukuoka University, Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Chem Phys Lipids 109:117-33. 2001
    ..DPPC) bilayer was investigated with special interest in possible difference between saturated and unsaturated fatty acids. The phase behavior of hydrated DPPC bilayer was followed by a differential scanning calorimetry and a ..
  62. ncbi Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women
    Tobias Pischon
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, Mass 02115, USA
    Circulation 108:155-60. 2003
    ..Polyunsaturated fatty acid intake favorably affects chronic inflammatory-related diseases such as cardiovascular disease; however, high intake of n-6 fatty acids may attenuate the known beneficial effects of n-3 fatty acids...
  63. ncbi Nutrigenomic approach to understanding the mechanisms by which dietary long-chain fatty acids induce gene signals and control mechanisms involved in carcinogenesis
    Pascale Anderle
    Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland
    Nutrition 20:103-8. 2004
  64. ncbi Lipid mediators from pollen act as chemoattractants and activators of polymorphonuclear granulocytes
    Claudia Traidl-Hoffmann
    Division of Environmental Dermatology and Allergy TUM GSF, Neuherberg, Germany
    J Allergy Clin Immunol 109:831-8. 2002
    ..In addition, we recently demonstrated that pollen are a rich source of eicosanoid-like mediators, which are rapidly released on contact with the aqueous phase...
  65. ncbi Polyunsaturated fatty acid biosynthesis: a microsomal-peroxisomal process
    H Sprecher
    The Department of Medical Biochemistry, The Ohio State University, Columbus 43210, USA
    Prostaglandins Leukot Essent Fatty Acids 60:317-21. 1999
    ..Collectively our findings suggest that there may be considerably more recycling of fatty acids between peroxisomes and the endoplasmic reticulum than was previously recognized...
  66. ncbi beta-oxidation - strategies for the metabolism of a wide variety of acyl-CoA esters
    J K Hiltunen
    Biocenter Oulu and Department of Biochemistry, University of Oulu, P O FIN 90014, Oulun yliopisto, Finland
    Biochim Biophys Acta 1484:117-28. 2000
    ....
  67. ncbi n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes
    E D Collett
    Molecular and Cell Biology Group, Faculty of Nutrition, and Center for Environmental and Rural Health, Texas A and M University, College Station, Texas 77843-2471, USA
    Am J Physiol Cell Physiol 280:C1066-75. 2001
    ..In view of the central role of oncogenic Ras in the development of colon cancer, the finding that n-3 and n-6 PUFA differentially modulate Ras activation may partly explain why dietary fish oil protects against colon cancer development...
  68. ncbi Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases
    Philip C Calder
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, UK
    Mol Nutr Food Res 52:885-97. 2008
    ..Clinical outcomes have been variably affected by fish oil, although some trials report improved gut histology, decreased disease activity, use of corticosteroids and relapse...
  69. pmc A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49
    Marc R Van Gilst
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143 2280, USA
    Proc Natl Acad Sci U S A 102:13496-501. 2005
    ..Our characterization of a fasting response system and our finding that nhr-49 regulates a sector within this system provide insight into the mechanisms by which animals respond to nutritional signals...
  70. ncbi Product diversity and regulation of type II fatty acid synthases
    Ying Jie Lu
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Biochem Cell Biol 82:145-55. 2004
    ..These include multiple mechanisms to generate unsaturated fatty acids and the accessory components required for branched-chain fatty acid synthesis in Gram-positive bacteria...
  71. ncbi A rapid wound signal activates the systemic synthesis of bioactive jasmonates in Arabidopsis
    Abraham J K Koo
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824, USA
    Plant J 59:974-86. 2009
    ..These results are consistent with a model in which a rapidly transmitted wound signal triggers the systemic synthesis of JA, which, upon conversion to JA-Ile, activates the expression of early response genes by the SCF(COI1)/JAZ pathway...
  72. ncbi Unsaturated fatty acids as cytoprotective agents in the pancreatic beta-cell
    Noel G Morgan
    Institute of Biomedical and Clinical Science, Peninsula Medical School University of Exeter, Plymouth, UK
    Prostaglandins Leukot Essent Fatty Acids 82:231-6. 2010
    ..to long chain fatty acids, such that saturated species are lipotoxic whereas long chain mono-unsaturated fatty acids can provide cytoprotection...
  73. pmc Elucidation of the double-bond position of long-chain unsaturated fatty acids by multiple-stage linear ion-trap mass spectrometry with electrospray ionization
    Fong Fu Hsu
    Mass Spectrometry Resource, Division of Endocrinology, Diabetes, Metabolism, and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Soc Mass Spectrom 19:1673-80. 2008
    ..the position of double bond(s) of unsaturated long-chain fatty acids and toward discerning among isomeric unsaturated fatty acids as dilithiated adduct ([M-H+2Li]+) ions are described in this report...
  74. ncbi Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL
    S Chyb
    Cambridge University Department of Anatomy, UK
    Nature 397:255-9. 1999
    ..As arachidonic acid may not be found in Drosophila, we suggest that another polyunsaturated fatty acid, such as linolenic acid, may be a messenger of excitation in Drosophila photoreceptors...
  75. pmc Molecular identification and characterization of the Arabidopsis delta(3,5),delta(2,4)-dienoyl-coenzyme A isomerase, a peroxisomal enzyme participating in the beta-oxidation cycle of unsaturated fatty acids
    Simon Goepfert
    Département de Biologie Moléculaire Végétale, Batiment de Biologie, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    Plant Physiol 138:1947-56. 2005
    Degradation of unsaturated fatty acids through the peroxisomal beta-oxidation pathway requires the participation of auxiliary enzymes in addition to the enzymes of the core beta-oxidation cycle...
  76. ncbi CRM1-dependent nuclear export and dimerization with hMSH5 contribute to the regulation of hMSH4 subcellular localization
    Sophie Neyton
    Equipe M3R, UMR 6543, Universite de Nice Sophia Antipolis, CNRS, Faculte de Medecine, Avenue de Valombrose 06107, Nice Cedex 2, France
    Exp Cell Res 313:3680-93. 2007
    ..Our findings suggest that nucleocytoplasmic traffic may constitute a regulatory mechanism for MSH4 and MSH5 functions...
  77. ncbi Evaluation of lipophilic antioxidant efficacy in vivo by the biomarkers hydroxyoctadecadienoic acid and isoprostane
    Yasukazu Yoshida
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31 Midorigaoka Ikeda, Osaka 563 8577, Japan
    Lipids 42:463-72. 2007
    ....
  78. ncbi Docosapentaenoic acid does not completely replace DHA in n-3 FA-deficient rats during early development
    Rebecca S Greiner
    Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, USA
    Lipids 38:431-5. 2003
    ..The lack of total 22-carbon (22C) FA in the brain during the rapid membrane biogenesis that occurs during early development could be a factor in the nervous system functional deficits associated with n-3 FA deficiency...
  79. ncbi Effects of three different highly purified n-3 series highly unsaturated fatty acids on lipid metabolism in C57BL/KsJ-db/db mice
    Naohiro Gotoh
    Department of Food Science and Technology, Tokyo University of Marine Science and Technology, 4 5 7 Konan, Minato ku, Tokyo 108 8477, Japan
    J Agric Food Chem 57:11047-54. 2009
    Triglycerides (TG) consisting of highly purified (>97%) n-3 series highly unsaturated fatty acids, eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA), were administered to C57BL/KsJ-db/db mice for ..
  80. ncbi Two aerobic pathways for the formation of unsaturated fatty acids in Pseudomonas aeruginosa
    Kun Zhu
    Department of Infectious Diseases, Protein Science Division, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mol Microbiol 60:260-73. 2006
    ....
  81. ncbi RNA helicase p54 (DDX6) is a shuttling protein involved in nuclear assembly of stored mRNP particles
    David A Smillie
    Division of Cell and Molecular Biology, School of Biology, University of St Andrews, St Andrews, Fife KY16 9TS, Scotland
    J Cell Sci 115:395-407. 2002
    ....
  82. ncbi Docosahexaenoic acid abundance in the brain: a biodevice to combat oxidative stress
    Ephraim Yavin
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
    Nutr Neurosci 5:149-57. 2002
    ..A neuroprotective role for DHA, possibly in association with the vinyl ether (VE) linkage of plasmalogens (pPLs) in combating free radicals is proposed...
  83. ncbi Effects of altering dietary fatty acid composition on prostaglandin synthesis and fertility
    D R Abayasekara
    Reproduction and Development Group, Department of Veterinary Basic Sciences, Royal Veterinary College, London, UK
    Prostaglandins Leukot Essent Fatty Acids 61:275-87. 1999
    ..In the male most recent work has focussed on sperm production and experiments in fowl have demonstrated clear effects of dietary PUFAs on both the sperm membrane phospholipid composition and on fertilizing ability...
  84. ncbi Relationships between the fatty acid composition of muscle and erythrocyte membrane phospholipid in young children and the effect of type of infant feeding
    L A Baur
    Department of Paediatrics and Child Health, University of Sydney NSW, Australia
    Lipids 35:77-82. 2000
    ....
  85. ncbi In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation
    Michael Maes
    M Care4U Outpatient Clinics, and the Clinical Research Center for Mental Health, Antwerp, Belgium
    Neuro Endocrinol Lett 26:745-51. 2005
    There is now evidence that major depression is accompanied by decreased levels of omega3 poly-unsaturated fatty acids (PUFA), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)...
  86. ncbi Effects of unsaturated fatty acids on progesterone secretion and selected protein kinases in goat granulosa cells
    S Coyral-Castel
    Institut National de la Recherche Agronomique, UMR 85 Physiologie de la Reproduction et des Comportements, Nouzilly, France
    Domest Anim Endocrinol 38:272-83. 2010
    ..Taken together, some fatty acids could improve ovarian steroidogenesis through the MAPK ERK1/2 signaling pathway and, consequently, have beneficial effects on goat fertility...
  87. ncbi Omega-3 PUFA of marine origin limit diet-induced obesity in mice by reducing cellularity of adipose tissue
    Jana Ruzickova
    Department of Adipose Tissue Biology and Centre for Integrated Genomics, Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic
    Lipids 39:1177-85. 2004
    ..Increased dietary intake of EPA/DHA may be beneficial regardless of the ALA intake...
  88. pmc cis-trans isomerization of unsaturated fatty acids: cloning and sequencing of the cti gene from Pseudomonas putida P8
    R Holtwick
    Institut fur Mikrobiologie, Westfalische Wilhelms Universitat Munster, Germany
    Appl Environ Microbiol 63:4292-7. 1997
    ..putida P8. A cti-carrying fragment integrated into a plasmid also conferred the ability for cis-trans isomerization to Escherichia coli; the cti gene was completely sequenced, and the amino acid sequence was deduced...
  89. ncbi Diets enriched in unsaturated fatty acids enhance early embryonic development in lactating Holstein cows
    G Thangavelu
    Dairy Research and Technology Centre, Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alta, Canada
    Theriogenology 68:949-57. 2007
    ..4+/-6.3, 132.3+/-8.3, and 89.3+/-9.6 cells, respectively). Although our hypothesis was only partially supported, embryonic development was enhanced in Holstein cows fed unsaturated fatty acids compared to those fed saturated fatty acids.
  90. ncbi Retinoid X receptor dominates the nuclear import and export of the unliganded vitamin D receptor
    Kirsten Prüfer
    Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Endocrinol 16:1738-51. 2002
    ..These results indicate that the unliganded and liganded VDR interact differently with the import and export receptors and with RXR. Most likely, the regulation of VDR nuclear import by RXR is essential for ligand-independent functions...
  91. ncbi Board-invited review: Recent advances in biohydrogenation of unsaturated fatty acids within the rumen microbial ecosystem
    T C Jenkins
    Department of Animal and Veterinary Sciences, Clemson University, Clemson, SC 29634, USA
    J Anim Sci 86:397-412. 2008
    ..now available, several attempts have been made at modeling the pathway to predict ruminal flows of unsaturated fatty acids and biohydrogenation intermediates across a range of ruminal conditions...
  92. ncbi Intake of unsaturated fatty acids and HDL cholesterol levels are associated with manifestations of atopy in adults
    T Schafer
    Department of Social Medicine, University Lübeck, Germany
    Clin Exp Allergy 33:1360-7. 2003
    The increase in allergic diseases is still unexplained. It was hypothesized that the intake of unsaturated fatty acids is a contributing cause of this development...
  93. ncbi NMR and quantum chemical study on the OH...pi and CH...O interactions between trehalose and unsaturated fatty acids: implication for the mechanism of antioxidant function of trehalose
    Kazuyuki Oku
    Amase Institute, Hayashibara Biochemical Laboratories, Inc, 7 7 Amaseminami machi, Okayama 700 0834, Japan
    J Am Chem Soc 125:12739-48. 2003
    ..Therefore, trehalose has a significant depression effect on the oxidation of UFA through the weak interaction with the double bond(s). This is the first study to elucidate the antioxidant function of trehalose...
  94. ncbi [Unsaturated fatty acids intake and breast cancer risk: epidemiological data review]
    Anne C M Thiebaut
    Equipe E3N EPIC, INSERM, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex
    Bull Cancer 92:658-69. 2005
    ..However, it is difficult in human to disentangle the effect of nutrient intake from that of contributing foods or even nutritional profile...
  95. ncbi Metabolic fate of long-chain unsaturated fatty acids and their effects on palmitic acid metabolism and gluconeogenesis in bovine hepatocytes
    D G Mashek
    Department of Dairy Science, University of Wisconsin, Madison 53706, USA
    J Dairy Sci 85:2283-9. 2002
    ..The unsaturated fatty acids also influenced palmitic acid metabolism...
  96. ncbi Metabolism and functions of highly unsaturated fatty acids: an update
    M T Nakamura
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Lipids 36:961-4. 2001
    ..This review briefly examines the recent progress in knowledge about the synthesis and degradation of highly unsaturated fatty acids (HUFA) and their functions...
  97. ncbi The "albumin effect" and in vitro-in vivo extrapolation: sequestration of long-chain unsaturated fatty acids enhances phenytoin hydroxylation by human liver microsomal and recombinant cytochrome P450 2C9
    Andrew Rowland
    Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, SA 5042, Australia
    Drug Metab Dispos 36:870-7. 2008
    ..The results indicate that previously determined in vitro K(m) values for CYP2C9 substrates are almost certainly overestimates, and accurate in vitro-in vivo extrapolation of kinetic data for CYP2C9 substrates is achievable...
  98. ncbi Plant oxylipins: plant responses to 12-oxo-phytodienoic acid are governed by its specific structural and functional properties
    Christine Böttcher
    CSIRO Plant Industry, Adelaide, Australia
    FEBS J 276:4693-704. 2009
    ..In this context, aspects such as the differential recruitment of OPDA, either by de novo biosynthesis or by release from cyclo-oxylipin-galactolipids, and the conjugation of free OPDA are discussed...
  99. ncbi Oxidation decomposition of unsaturated fatty acids by singlet oxygen in phospholipid bilayer membranes
    Naoki Watabe
    Faculty of Biomedical Engineering, Toin University of Yokohama, Yokohama, Japan
    J Oleo Sci 56:73-80. 2007
    Oxidation decomposition of unsaturated fatty acids with singlet oxygen generated from a photosensitizing agent was investigated in liposome bilayer membranes under a light irradiation condition...
  100. ncbi Effect of in vitro docosahexaenoic acid supplementation to marine algae-adapted and unadapted rumen inoculum on the biohydrogenation of unsaturated fatty acids in freeze-dried grass
    B Vlaeminck
    Laboratory for Animal Nutrition and Animal Product Quality, Ghent University, Proefhoevestraat 10, 9090 Melle, Belgium
    J Dairy Sci 91:1122-32. 2008
    ....
  101. ncbi Changes in Na+/K+-ATPase activity, unsaturated fatty acids and metallothioneins in gills of the shore crab Carcinus aestuarii after dilute seawater acclimation
    C Lucu
    Center for Marine Research, Ruder Boskovic Institute, 52210 Rovinj, Croatia
    Comp Biochem Physiol A Mol Integr Physiol 149:362-72. 2008
    ..Assuming an antioxidant role of MT associated with intracellular zinc partitioning, the observed MT induction in posterior gills may be considered an adaptive response of C. aestuarii to hyposmotic stress...

Research Grants73

  1. Role of SCD1 and Dietary Methionine Restriction on Energy Homeostasis
    ERIC PAUL PLAISANCE; Fiscal Year: 2011
    ..is increased in obesity and catalyzes the conversion of saturated fatty acids (16:0 and 18:0) to mono- unsaturated fatty acids (16:1 and 18:1)...
  2. REGULATION OF GENE EXPRESSION BY DIETARY FAT
    Lisa M Salati; Fiscal Year: 2012
    ..This project will provide important new data on the ways in which dietary fat can regulate intracellular metabolism. ..
  3. PUFA Synthesis and the Control of Hepatic Metabolism
    Donald B Jump; Fiscal Year: 2013
    ..Defining the mechanistic linkage between PUFA synthesis, TAG hydrolysis, FoxO1, GNG &stress pathways will identify novel methods to manage diabetic complications, like hyperglycemia &fatty liver. ..
  4. Dietary Lipids and Silica-Accelerated Autoimmunity
    James J Pestka; Fiscal Year: 2013
    ..Finally, it is expected that these studies will reveal additional potential benefits of n-3 PUFA consumption on silica-induced lung disease and fibrosis, another understudied area. ..
  5. Role of ALDH7A1 in Ethanol-Induced Oxidative Damage
    CHAD NICHOLAS BROCKER; Fiscal Year: 2011
    ..This long term goal of this project is to elucidate the protective functions of ALDH7A1 during excessive alcohol consumption. ..
  6. Metabolic Actions of Omega-3 Fatty Acids on Inflammation
    Michael Miller; Fiscal Year: 2013
    ..Favorable outcomes from this study could translate into a new approach to improve heart disease risk in men and women with the metabolic syndrome. ..
  7. Role of NPC1L1 in regulating energy metabolism, nutrient utilization & weight gai
    Philip N Howles; Fiscal Year: 2010
    ..inhibiting cholesterol absorption reduces saturated fatty acid absorption without affecting absorption of unsaturated fatty acids. In vitro, cell culture, and in vivo experiments will test the hypothesis that unabsorbed cholesterol ..
  8. Fatty Acid Defects &Oxidative Stress Modulate Islet Function in Cystic Fibrosis
    Aliye Uc; Fiscal Year: 2013
    ..The long-term goal is to develop improved therapies to prevent the insulin secretory defects in CF and the progression to CFRD. ..
  9. Prevention of high fat diet-induced vascular injury
    Ming Hui Zou; Fiscal Year: 2013
    ..It is anticipated that the completion of this project will yield important insights into how omega-3 polyunsaturated fatty acids protect against cardiovascular diseases. ..
  10. NKT cells, fatty acids, and insulin resistance
    CURTIS LEE GABRIEL; Fiscal Year: 2010
    ..free fatty acids by using an in vitro model of indirect NKT cell activation and a panel of saturated and unsaturated fatty acids. Our second aim will investigate how NKT cell activity is influenced by specific diets...
  11. The Role of Cyp2b in Toxicant Metabolism and Sensitivity
    William S Baldwin; Fiscal Year: 2012
    ..oil as a carrier revealed that Cyp2b-KD mice but not wild-type mice are unable to properly depurate the unsaturated fatty acids from the liver. This suggests an important role for Cyp2b in lipid homeostasis...
  12. Fatty acid Control Obesity and the Metabolic Syndrome via TPR proteins
    Terry D Hinds; Fiscal Year: 2010
    ..Factors that control obesity via dietary intake or supplemental control are of much interest. Unsaturated fatty acids, especially polyunsaturated fatty acids, have been shown in clinical and animal studies to be useful in ..
  13. Molecular Mechanisms of Mitigation of Insulin Induction of SREBP-1c by N-3 PUFA
    Marshall B Elam; Fiscal Year: 2013
    ..We are examining the ability of highly unsaturated fatty acids (Polyunsaturated Fatty Acids or PUFA) derived from fish oil to reduce fat production in the liver by ..
  14. Fatty acid desaturase activity, fish oil and colorectal cancer chemoprevention
    Harvey J Murff; Fiscal Year: 2013
    ..We anticipate that fish oil will have anti-neoplastic effect and individuals with low FADS1 activity will have a greater response compared to individuals with high FADS1 activity. ..
  15. RESEARCH CENTER FOR PHARMACOLOGY AND DRUG TOXICOLOGY
    L Jackson Roberts; Fiscal Year: 2010
    ..It is anticipated that the projects proposed will significantly advance our understanding of the pharmacology and biology of eicosanoids and related compounds. ..
  16. Alterations in membrane composition and function eith calorie restriction
    Jon J Ramsey; Fiscal Year: 2011
    ..Also, NAD(P)H-quinone reductase knockout (NQO1 KO) mice will be used to determine if stimulation of the PM redox system is required for life span extension with CR. ..
  17. SECOND MESSENGERS IN THE RETINA
    RAJU VS RAJALA; Fiscal Year: 2012
    ..Our long-term goal is to understand these mechanisms as a foundation on which novel drug therapies can be designed to protect retinal function in patients who suffer from retinal degenerations. ..
  18. Colonic Cytokinetics and Cell Signaling: Dietary Effects
    ROBERT STEPHEN CHAPKIN; Fiscal Year: 2012
    ....
  19. Obesity related pancreatic fat worsens local injury via unsaturated fatty acids
    VIJAY PREM SINGH; Fiscal Year: 2013
    ..We therefore hypothesize that obesity-associated intrapancreatic fat worsens pancreatic injury via unsaturated fatty acids generated from local lipolysis...
  20. Tumor -Targeting Chemotherapeutic Agents
    Iwao Ojima; Fiscal Year: 2013
    ..This proposal deals with novel tumor-targeting drug delivery systems to address these urgent medical issues. ..
  21. The altered lipid and protein metabolism of pediatric patients with HIV infection
    Farook Jahoor; Fiscal Year: 2010
    ..of high density lipoprotein apoprotein Al (HDL-apoAl), 3) a lower fat diet rich in poly and mono- unsaturated fatty acids will improve the hypertriglyceridemia and hypercholesterolemia of HIV-infected dyslipidemic subjects...
  22. Obesity, Biomechanics, and Inflammation in Osteoarthritis
    Farshid Guilak; Fiscal Year: 2013
    ..mice fed high-fat diets high in saturated and monounsaturated fatty acids, or omega-3 or omega-6 poly-unsaturated fatty acids. In Aim 2, we will examine the effects of obesity (via high-fat diet or leptin deficiency) and weight ..
  23. Effects of insulin on the microvasculature
    EUGENE JOSEPH BARRETT; Fiscal Year: 2013
    ....
  24. Human CYP1A1, diet and dioxin-induced hypertension
    Mary K Walker; Fiscal Year: 2012
    ....
  25. The role of phosphorylation in regulating the antidiabetic effects of O3FAR-1
    Nader H Moniri; Fiscal Year: 2013
    ..to as GPR120, is a G protein-coupled receptor (GPCR) that has been shown to be agonized by long chained unsaturated fatty acids, specifically, those belonging to the omega-3 fatty acid (O3FA) family...
  26. LIPID MODULATION OF RHODOPSIN SIGNALING IN MEMBRANES
    Michael F Brown; Fiscal Year: 2010
    ..This work is pertinent to the role of polyunsaturated lipids in the function and dysfunction of central nervous system of humans with attendant insights that may be of eventual therapeutic benefit. ..
  27. Omega-3 PUFA suppress adipochemokines in human obesity
    Rachana Shah; Fiscal Year: 2013
    ....
  28. CNS PPAR gamma and energy homeostasis
    HEIDI E KOCALIS; Fiscal Year: 2011
    ..If a role for PPARy in CNS controlled energy homeostasis is indicated, this will establish the brain as yet another target of PPARy agonist drugs. ..
  29. Southern Community Cohort Study
    Wei Zheng; Fiscal Year: 2013
    ..abstract_text> ..
  30. Role of Astrocytic TREK-2 Potassium Channels in Cerebral Ischemia
    Misty J Eaton; Fiscal Year: 2013
    ....
  31. MEMBRANE BASIS OF VISUAL EXCITATION
    Michael F Brown; Fiscal Year: 2012
    ..Understanding the protein and lipid components of visual membranes is vitally significant to the prevention of human diseases. ..
  32. Mitochondrial Bioenergetic Dysfunction and Chlorine Toxicity
    Sadis Matalon; Fiscal Year: 2013
    ..are depleted, it fors relatively stable adducts with proteins, components of the extracellular matrix and unsaturated fatty acids which then proceed to prolong the toxicity of the initial Cl2 exposure and contribute t the long term ..
  33. Dietary Fat in Ethanol-Induced Intestinal Barrier Dysfunction in ALD
    Irina Kirpich; Fiscal Year: 2013
    ..Dietary modulation may represent a novel preventive/therapeutic approach in ALD, and MLCK could be a specific novel therapeutic target. ..
  34. PAF Receptor Trafficking and Function in Epithelial Cells
    Tamas Jilling; Fiscal Year: 2010
    ..These studies will elucidate the mechanisms of PAFR targeting in epithelial cells, and a novel mechanism by which PUFA might affect the function of PAFR, and other GPCR-s. ..
  35. Established Investigator Award Anti-Inflammatory Exposures in Cancer Prevention
    Emily White; Fiscal Year: 2013
    ..To accomplish this, the applicant will reduce her large administrative responsibilities, including stepping down from her role as Associate Dean for Research in the University of Washington School of Public Health. ..
  36. Functional Analysis of MGAT Enzymes
    Robert V Farese; Fiscal Year: 2010
    ..Additionally, if MGAT2 deficiency protects against diet-induced obesity, it may also protect against diet-induced insulin resistance and type 2 diabetes. ..
  37. GENETIC DISSECTION OF PHOTOTRANSDUCTION
    Baruch Minke; Fiscal Year: 2011
    ..Therefore, studies on Drosophila TRP and TRPL channels are likely to be relevant for understanding retinal degeneration and mechanisms underlying the damage to RGC by glaucoma. ..
  38. Genetic Approaches to Lipid Metabolism
    John E Cronan; Fiscal Year: 2013
    ..A second focus will be on the mechanisms of synthesis of unsaturated fatty acids, an essential component of the membrane lipids of most bacteria...
  39. MOLECULAR REGULATION OF APOPROTEIN B DEGRADATION
    Edward A Fisher; Fiscal Year: 2012
    ..abstract_text> ..
  40. Maternal Diet and Susceptibility to Neonatal Brain Injury
    John D Barks; Fiscal Year: 2013
    ..S. population. ..
  41. Regulation of Mitochondrial Dysfunction and Diet-Induced Obesity by ALCAT1
    Yuguang Shi; Fiscal Year: 2012
    ....
  42. Effect of Nutritional Factors on Macrophage Accumulation in Adipose Tissue
    Alan Chait; Fiscal Year: 2012
    ..abstract_text> ..
  43. FUNCTION AND REGULATION OF GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 2
    MARIA R GONZALEZ BARO; Fiscal Year: 2012
    ....
  44. Stress, Mood, Omega-3 Fatty Acids, &Telomeric Aging: Randomized Controlled Trial
    Janice K Kiecolt-Glaser; Fiscal Year: 2012
    ..By adding cell aging assessments to an ongoing randomized controlled trial of omega-3 supplementation, we can assess how omega-3 supplementation affects both telomerase activity and telomere length, as well as possible mechanisms. ..
  45. Mechanisms by which Obesity in Pregnancy Leads to Obesity in Offspring
    Rebecca A Simmons; Fiscal Year: 2013
    ..Since the incidence of obesity is rapidly increasing in the United States, these studies will have great impact on health. ..
  46. Protective Effects of Fatty Acids in Phthalate-Induced Inflammation in Neonates
    ANNA MARIE VETRANO; Fiscal Year: 2013
    ..These findings will address this need, and may suggest novel nutritional interventions to prevent chronic inflammatory conditions associated with exposure to phthalates in neonates. ..
  47. N-3 Fatty Acid-Induced Akt Suppression: Chemoprevention for Pancreatic Neoplasia
    PAUL JOSEPH GRIPPO; Fiscal Year: 2013
    ....
  48. Lipid electrophile adduction of Pin1 and effects on substrate binding &activity
    Christopher D Aluise; Fiscal Year: 2013
    ..The proposed research allows for significant insight into the cellular response to Pin1 protein modification as a consequence of lipid peroxidation. ..
  49. Molecular mechanism of omega-3 response
    JAMES T BRENNA; Fiscal Year: 2013
    ..Human genetic variation and metabolic conditions responsive to omega-3 LCPUFA supplementation will be identified. ..
  50. Genetics of Obesity in Yup'ik Eskimos
    BERT BRANDON BOYER; Fiscal Year: 2011
    ..abstract_text> ..
  51. Prostaglandins in C. elegans Fertilization
    Michael A Miller; Fiscal Year: 2013
    ..Regardless, basic research on prostaglandins in the C. elegans gonad has the potential for discovering molecular mechanisms of human infertility, contraception, and cancer. ..
  52. Formation of Omega 3-Derived Electrophiles During Inflammation
    FRANCISCO JOSE SCHOPFER; Fiscal Year: 2013
    ..It is expected that this proposal will lead to a better understanding of w-3 fatty acid effects and to improved pharmacological approaches to decrease atherosclerosis and its detrimental effects. ..
  53. Stress and Proinflammatory Cytokines: Omega-3 Intervention
    Janice Kiecolt Glaser; Fiscal Year: 2009
    ....
  54. Metabolic requirements of adult neural stem cells
    Philip J Horner; Fiscal Year: 2012
    ..We hope to impact public health by identifying mechanisms underlying behavior-induced changes in cellular activity, especially in cells capable of regeneration within the adult and aging brain. ..
  55. Naturally Occurring Lipid Mediators Enhance Antibody Production
    Richard P Phipps; Fiscal Year: 2013
    ..The stimulatory properties of SPM will be further assessed by challenging immunized mice with live influenza viral strains, including the 2009 H1N1, and monitoring weight loss, survival, and viral titers. ..
  56. Nitro-Fatty Acids and Nrf2 in Vascular Remodeling
    Yuqing Eugene Chen; Fiscal Year: 2013
    ..NO) and ROS, react with carbohydrates, DNA bases, protein tyrosine/tryptophan, and unsaturated fatty acids to form relatively stable nitrated products...
  57. Neuroimaging of Fatty Acids in Major Depression
    M Elizabeth Sublette; Fiscal Year: 2012
    ..This study is expected to contribute to understanding the neurobiology of depression and may provide new information relevant to treatment with dietary fatty acids. ..
  58. The Wake Forest Center for Botanical Lipids and Inflammatory Disease Prevention
    Floyd H Chilton; Fiscal Year: 2013
    ..The central hypothesis of the Center is that medium chain poly-unsaturated fatty acids (PUFAs) in botanical oils and their metabolites impact several key mechanisms (including altering pro-and ..
  59. Understanding the influence of n-3 PUFA on pro-inflammatory aspects of mercury
    Allen J Rosenspire; Fiscal Year: 2013
    ..Both in vitro and in vivo models will be employed, where the plan is to utilize western blotting techniques, as well as flow cytometric-based technology to map CD95 signaling networks. ..
  60. GLUTAMATE-GATED CHANNELS IN CENTRAL &PERIPHERAL NEURONS
    James E Huettner; Fiscal Year: 2013
    ..pore loop and adjacent transmembrane helices govern kainate receptor susceptibility to inhibition by cis-unsaturated fatty acids, such as docosahexaenoic acid (DHA)...
  61. Non-pharmacological control of atherosclerosis
    Sampath Parthasarathy; Fiscal Year: 2013
    ..Sesame oil contains equal amounts of mono- and poly unsaturated fatty acids and contains bio-active non-saponifiable components that are potent antioxidants and PPAR1 agonists...
  62. Lipid Mediators of Insulin Resistance
    Scott A Summers; Fiscal Year: 2012
    ..Aim Two: Phosphatidic acid, and not diacyglycerol, links unsaturated fatty acids to the induction of insulin resistance through the target protein mTOR...
  63. DIETARY LIPIDS--EFFECTS ON LIPID-LIPOPROTEIN METABOLISM
    D Illingworth; Fiscal Year: 1991
    ..Overall, these studies should enhance our knowledge concerning the clinical and metabolic effects of specific dietary lipids and have direct therapeutic application to treatment of subjects with hypercholesterolemia...
  64. Pilot Study on Mammary Expression of Novel Desaturases
    ALISON VAN EENENNAAM; Fiscal Year: 2005
    ....
  65. POLYUNSATURATES AND KC1 TO CONTROL MILD HYPERTENSION
    Frank Sacks; Fiscal Year: 1991
    ..Biochemical validation of compliance with each treatment will be obtained. The discovery of an effective dietary supplement to treat mild hypertension would be of great interest and practical importance...
  66. EFFECTS OF POLYUNSATURATED FATTY ACIDS ON MEGAKARYOCYTES
    PAUL SCHICK; Fiscal Year: 1991
    ..on the lipid composition, desaturase activity, and the uptake and transfer of arachidonic acid and other unsaturated fatty acids will be determined...
  67. Refinement of LC/ESR/MS for Studying Lipid Free Radicals in Colon Cancer Growth
    Steven Qian; Fiscal Year: 2009
    ..We anticipate that the outcome of our research will open a new door into knowledge of PUFA peroxidation in cancer biology and will revolutionize how we use our knowledge of enzymatic peroxidation to control colon cancer. ..
  68. DIETARY N-3 FATTY ACIDS: TRANSPORT AND UPTAKE INTO BRAIN
    Gregory Anderson; Fiscal Year: 1993
    ....
  69. Regulation of syndecan 1 in by n-3 PUFA
    IRIS EDWARDS; Fiscal Year: 2009
    ..abstract_text> ..
  70. Prevention of Post-Prandial Hypoglycemia Using n-3/n-6 PUFA in PCOS
    SIDIKA KARAKAS; Fiscal Year: 2009
    ..Our aim is to identify the best supplement that can prevent hypoglycemia and its unwanted consequences in these young women-an under-studied patient population. ..
  71. ALTERED MEMBRANE PHOSPHOLIPIDS AND CARDIAC FUNCTION
    DIANE REIBEL; Fiscal Year: 1990
    ..The proposed studies will further our understanding of the effects of dietary fish oil on cardiac function and the pathogenesis of myocardial ischemia...
  72. NUTRITIONAL SIGNIFICANCE OF POLYUNSATURATED FATTY ACIDS
    Vincent Ziboh; Fiscal Year: 1990
    ..Taken together, these studies should provide information on the dietary role of each of the PUFA on 14C-AA metabolism by epidermis and PMNs as well as on PMNs function...
  73. OMEGA-3 FATTY ACIDS IN NORMAL VISUAL DEVELOPMENT
    Eileen Birch; Fiscal Year: 2003
    ..By relating long-term outcomes to visual cortical function during infancy, we will directly evaluate the predictive of early visual tests for long-term cognitive outcomes. ..