mupirocin

Summary

Summary: A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.

Top Publications

  1. ncbi Selective use of intranasal mupirocin and chlorhexidine bathing and the incidence of methicillin-resistant Staphylococcus aureus colonization and infection among intensive care unit patients
    Glenn Ridenour
    Division of Infectious Diseases, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA 23236, USA
    Infect Control Hosp Epidemiol 28:1155-61. 2007
  2. ncbi Mupirocin resistance
    Jean B Patel
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Infect Dis 49:935-41. 2009
  3. ncbi Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin
    L F Silvian
    Department of Molecular Biophysics, Yale University, and Howard Hughes Medical Institute, New Haven, CT 06520 8114, USA
    Science 285:1074-7. 1999
  4. pmc Targeted intranasal mupirocin to prevent colonization and infection by community-associated methicillin-resistant Staphylococcus aureus strains in soldiers: a cluster randomized controlled trial
    Michael W Ellis
    Department of Medicine, Brooke Army Medical Center, Infectious Disease Service MCHE MDI, Fort Sam Houston, TX 78234, USA
    Antimicrob Agents Chemother 51:3591-8. 2007
  5. pmc Global analysis of the Staphylococcus aureus response to mupirocin
    Swantje Reiss
    Institut fur Mikrobiologie, Ernst Moritz Arndt Universitat, Greifswald, Germany
    Antimicrob Agents Chemother 56:787-804. 2012
  6. ncbi Quorum-sensing-dependent regulation of biosynthesis of the polyketide antibiotic mupirocin in Pseudomonas fluorescens NCIMB 10586
    A K El-Sayed
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Microbiology 147:2127-39. 2001
  7. ncbi Intranasal mupirocin reduces sternal wound infection after open heart surgery in diabetics and nondiabetics
    G E Cimochowski
    Department of Cardiac Surgery, Wilkes-Barre General Hospital, Pennsylvania, USA
    Ann Thorac Surg 71:1572-8; discussion 1578-9. 2001
  8. pmc A novel chimeric lysin shows superiority to mupirocin for skin decolonization of methicillin-resistant and -sensitive Staphylococcus aureus strains
    Mina Pastagia
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY 10065, USA
    Antimicrob Agents Chemother 55:738-44. 2011
  9. ncbi Asymptomatic nasal carriage of mupirocin-resistant, methicillin-resistant Staphylococcus aureus (MRSA) in a pet dog associated with MRSA infection in household contacts
    Farrin A Manian
    Division of Infectious Diseases, St John s Mercy Medical Center, St Louis, Missouri 63141, USA
    Clin Infect Dis 36:e26-8. 2003
  10. ncbi Nasal lavage with mupirocin for the treatment of surgically recalcitrant chronic rhinosinusitis
    Brent Uren
    Department of Surgery Otolaryngology, University of Adelaide, Woodville, Australia
    Laryngoscope 118:1677-80. 2008

Detail Information

Publications232 found, 100 shown here

  1. ncbi Selective use of intranasal mupirocin and chlorhexidine bathing and the incidence of methicillin-resistant Staphylococcus aureus colonization and infection among intensive care unit patients
    Glenn Ridenour
    Division of Infectious Diseases, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA 23236, USA
    Infect Control Hosp Epidemiol 28:1155-61. 2007
    To determine whether the use of chlorhexidine bathing and intranasal mupirocin therapy among patients colonized with methicillin-resistant Staphylococcus aureus (MRSA) would decrease the incidence of MRSA colonization and infection among ..
  2. ncbi Mupirocin resistance
    Jean B Patel
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Infect Dis 49:935-41. 2009
    ..methicillin-resistant Staphylococcus aureus (MRSA) infection, it is possible that there will be increased use of mupirocin for nasal decolonization of MRSA...
  3. ncbi Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin
    L F Silvian
    Department of Molecular Biophysics, Yale University, and Howard Hughes Medical Institute, New Haven, CT 06520 8114, USA
    Science 285:1074-7. 1999
    ..The 2.2 angstrom resolution crystal structure of Staphylococcus aureus IleRS complexed with tRNA(Ile) and Mupirocin shows the acceptor strand of the tRNA(Ile) in the continuously stacked, A-form conformation with the 3' terminal ..
  4. pmc Targeted intranasal mupirocin to prevent colonization and infection by community-associated methicillin-resistant Staphylococcus aureus strains in soldiers: a cluster randomized controlled trial
    Michael W Ellis
    Department of Medicine, Brooke Army Medical Center, Infectious Disease Service MCHE MDI, Fort Sam Houston, TX 78234, USA
    Antimicrob Agents Chemother 51:3591-8. 2007
    ..conducted a cluster randomized, double-blind, placebo-controlled trial to determine whether targeted intranasal mupirocin therapy in CA-MRSA-colonized soldiers could prevent infection in the treated individual and prevent new ..
  5. pmc Global analysis of the Staphylococcus aureus response to mupirocin
    Swantje Reiss
    Institut fur Mikrobiologie, Ernst Moritz Arndt Universitat, Greifswald, Germany
    Antimicrob Agents Chemother 56:787-804. 2012
    In the present study, we analyzed the response of S. aureus to mupirocin, the drug of choice for nasal decolonization...
  6. ncbi Quorum-sensing-dependent regulation of biosynthesis of the polyketide antibiotic mupirocin in Pseudomonas fluorescens NCIMB 10586
    A K El-Sayed
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Microbiology 147:2127-39. 2001
    b>Mupirocin (pseudomonic acid) is a polyketide antibiotic, targeting isoleucyl-tRNA synthase, and produced by Pseudomonas fluorescens NCIMB 10586...
  7. ncbi Intranasal mupirocin reduces sternal wound infection after open heart surgery in diabetics and nondiabetics
    G E Cimochowski
    Department of Cardiac Surgery, Wilkes-Barre General Hospital, Pennsylvania, USA
    Ann Thorac Surg 71:1572-8; discussion 1578-9. 2001
    BACKGROUND: This study was designed to determine whether decreasing nasal bacterial colonization by applying Mupirocin (MPN) intranasally decreases sternal wound infections...
  8. pmc A novel chimeric lysin shows superiority to mupirocin for skin decolonization of methicillin-resistant and -sensitive Staphylococcus aureus strains
    Mina Pastagia
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY 10065, USA
    Antimicrob Agents Chemother 55:738-44. 2011
    ..aureus. Unlike the standard topical antibacterial agent mupirocin, ClyS eradicated a significantly greater number of methicillin-susceptible S. aureus (MSSA) and -resistant S...
  9. ncbi Asymptomatic nasal carriage of mupirocin-resistant, methicillin-resistant Staphylococcus aureus (MRSA) in a pet dog associated with MRSA infection in household contacts
    Farrin A Manian
    Division of Infectious Diseases, St John s Mercy Medical Center, St Louis, Missouri 63141, USA
    Clin Infect Dis 36:e26-8. 2003
    ..Culture of nares samples from the family dog grew mupirocin-resistant (minimum inhibitory concentration >1024 microg/mL) MRSA that had a pulsed-field gel electrophoresis ..
  10. ncbi Nasal lavage with mupirocin for the treatment of surgically recalcitrant chronic rhinosinusitis
    Brent Uren
    Department of Surgery Otolaryngology, University of Adelaide, Woodville, Australia
    Laryngoscope 118:1677-80. 2008
    To examine the efficacy and tolerability of topical mupirocin for the management of surgically recalcitrant chronic rhinosinusitis (CRS) associated with Staphylococcus aureus infection.
  11. ncbi Intranasal mupirocin to prevent postoperative Staphylococcus aureus infections
    Trish M Perl
    University of Iowa Colleges of Medicine and Public Health, Iowa City, USA
    N Engl J Med 346:1871-7. 2002
    ..Treatment with mupirocin ointment can reduce the rate of nasal carriage and may prevent postoperative S. aureus infections.
  12. ncbi Multidrug-resistant clones of community-associated meticillin-resistant Staphylococcus aureus isolated from Chinese children and the resistance genes to clindamycin and mupirocin
    Lijuan Wang
    Key Laboratory of Major Disease in Children and National Key Discipline of Pediatrics, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children s Hospital, Capital Medical University, Beijing, PR China
    J Med Microbiol 61:1240-7. 2012
    ..CA) meticillin-resistant Staphylococcus aureus (MRSA) to identify the genes responsible for clindamycin and mupirocin resistance in S. aureus isolates from paediatric hospitals in mainland China. A total of 435 S...
  13. pmc An in vitro biofilm model to examine the effect of antibiotic ointments on biofilms produced by burn wound bacterial isolates
    Adrienne A Hammond
    Department of Surgery, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA
    Burns 37:312-21. 2011
    ..Yet, a simple in vitro assay to compare the susceptibility of biofilms produced by burn wound isolates to different topical antibiotics has not been reported...
  14. ncbi Relationship of protein structure of isoleucyl-tRNA synthetase with pseudomonic acid resistance of Escherichia coli. A proposed mode of action of pseudomonic acid as an inhibitor of isoleucyl-tRNA synthetase
    T Yanagisawa
    Department of Molecular Biology, School of Science, Nagoya University, Japan
    J Biol Chem 269:24304-9. 1994
    ....
  15. ncbi In vitro activity of lysostaphin, mupirocin, and tea tree oil against clinical methicillin-resistant Staphylococcus aureus
    Kerry L LaPlante
    Department of Pharmacy Practice, University of Rhode Island, Veterans Affairs Medical Center, Providence, RI 02908, USA
    Diagn Microbiol Infect Dis 57:413-8. 2007
    ..We examined the activity of lysostaphin, mupirocin, and tea tree oil against clinical MRSA (n = 98) isolates. MIC(50) (range) were as follows: lysostaphin, 0...
  16. ncbi A randomized trial of mupirocin sinonasal rinses versus saline in surgically recalcitrant staphylococcal chronic rhinosinusitis
    Joshua Jervis-Bardy
    Department of Otorhinolaryngology Head and Neck Surgery, University of Adelaide and Flinders University, Adelaide, Australia
    Laryngoscope 122:2148-53. 2012
    Chronic rhinosinusitis (CRS) recalcitrant to surgery is a frustrating clinical entity. Recently, mupirocin sinonasal rinses have been suggested as an efficacious treatment alternative in these patients where Staphylococcus aureus ..
  17. pmc Development of microsponges for topical delivery of mupirocin
    Netal Amrutiya
    Department of Pharmaceutical Technology, C U Shah College of Pharmacy, S N D T Women s University, Santacruz W, Mumbai, 400049, Maharashtra, India
    AAPS PharmSciTech 10:402-9. 2009
    The goal of the present study was to develop and evaluate microsponge-based topical delivery system of mupirocin for sustained release and enhanced drug deposition in the skin...
  18. ncbi Mupirocin: biosynthesis, special features and applications of an antibiotic from a gram-negative bacterium
    Rachel Gurney
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Appl Microbiol Biotechnol 90:11-21. 2011
    b>Mupirocin is a polyketide antibiotic produced by Pseudomonas fluorescens. The biosynthetic cluster encodes 6 type I polyketide synthase multifunctional proteins and 29 single function proteins...
  19. ncbi In vitro activity of mupirocin on clinical isolates of Staphylococcus aureus and its potential implications in chronic rhinosinusitis
    Kien R Ha
    Department of Surgery Otorhinolaryngology Head and Neck Surgery, The University of Adelaide, Adelaide, South Australia
    Laryngoscope 118:535-40. 2008
    ..This study investigates the effectiveness of mupirocin and two other antibiotics, ciprofloxacin and vancomycin, on established in vitro biofilms of Staphylococcus ..
  20. ncbi Resistance to and synthesis of the antibiotic mupirocin
    Christopher M Thomas
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Nat Rev Microbiol 8:281-9. 2010
    b>Mupirocin, a polyketide antibiotic produced by Pseudomonas fluorescens, is used to control the carriage of methicillin-resistant Staphylococcus aureus on skin and in nasal passages as well as for various skin infections...
  21. ncbi Dynamic of nasal colonization by methicillin-resistant Staphylococcus aureus ST398 and ST1 after mupirocin treatment in a family in close contact with pigs
    Carmen Lozano
    Area Bioquímica y Biología Molecular, Universidad de La Rioja, Logrono, Spain
    Comp Immunol Microbiol Infect Dis 34:e1-7. 2011
    Nasal colonization by methicillin-resistant Staphylococcus aureus (MRSA) was evaluated after a mupirocin treatment in a family previously colonized by MRSA sequence type ST398 and ST1, who lived close to a pig farm...
  22. ncbi Impact of combined low-level mupirocin and genotypic chlorhexidine resistance on persistent methicillin-resistant Staphylococcus aureus carriage after decolonization therapy: a case-control study
    Andie S Lee
    Infection Control Program, Department of Infectious Diseases and Microbiology, Royal Prince Alfred Hospital, Sydney, Australia
    Clin Infect Dis 52:1422-30. 2011
    The clinical importance of low-level mupirocin resistance and genotypic chlorhexidine resistance remains unclear...
  23. pmc Effect of mupirocin treatment on nasal, pharyngeal, and perineal carriage of Staphylococcus aureus in healthy adults
    Heiman F L Wertheim
    Erasmus MC, University Hospital Rotterdam, Department of Clinical Microbiology and Infectious Diseases, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Antimicrob Agents Chemother 49:1465-7. 2005
    Nasal carriage of Staphylococcus aureus is an important risk factor for S. aureus infections. Mupirocin nasal ointment is presently the treatment of choice for decolonizing the anterior nares...
  24. ncbi Mupirocin prophylaxis against nosocomial Staphylococcus aureus infections in nonsurgical patients: a randomized study
    Heiman F L Wertheim
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands
    Ann Intern Med 140:419-25. 2004
    ..aureus infection. Studies show that intranasal mupirocin can prevent nosocomial surgical site infections...
  25. ncbi The evaluation of a mupirocin-based selective medium for the enumeration of bifidobacteria from probiotic animal feed
    P J Simpson
    Teagasc, Dairy Products Research Centre, Moorepark, Fermoy, Co Cork, Ireland
    J Microbiol Methods 57:9-16. 2004
    In this study, MRS medium supplemented with cysteine hydrochloride and mupirocin, termed Bifidobacterium selective medium (BSM) was found to be elective for bifidobacteria but inhibitory to a wide range of non-bifidobacteria strains ..
  26. ncbi A clinical trial of mupirocin in the eradication of methicillin-resistant Staphylococcus aureus nasal carriage in a digestive disease unit
    C Dupeyron
    Laboratoire de Microbiologie, Hopital Albert Chenevier, Creteil, France
    J Hosp Infect 52:281-7. 2002
    ..The efficacy of a program of nasal carriage eradication with mupirocin was evaluated simultaneously...
  27. pmc Acquisition of high-level mupirocin resistance and its fitness cost among methicillin-resistant Staphylococcus aureus strains with low-level mupirocin resistance
    Kanokporn Mongkolrattanothai
    Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Illinois College of Medicine at Peoria, Ilinois 61637, USA
    J Clin Microbiol 47:4158-60. 2009
    We investigated whether methicillin (meticillin)-resistant Staphylococcus aureus (MRSA) isolates with low-level mupirocin resistance can serve as recipients of a pSK41-like plasmid conferring high-level mupirocin resistance without ..
  28. ncbi Antibacterial activity of propolis against MRSA and synergism with topical mupirocin
    Yusuf Onlen
    Department of Infectious Diseases and Clinical Microbiology, Mustafa Kemal University Faculty of Medicine, Hatay, Turkey
    J Altern Complement Med 13:713-8. 2007
    The aim of the present study was to investigate the activity of the propolis and its combinations with mupirocin against methicillin-resistant Staphylococcus aureus (MRSA) in nasal carriage.
  29. pmc The NOSE study (nasal ointment for Staphylococcus aureus eradication): a randomized controlled trial of monthly mupirocin in HIV-infected individuals
    Rachel J Gordon
    Department of Medicine, Columbia University, New York, NY, USA
    J Acquir Immune Defic Syndr 55:466-72. 2010
    ..HIV-positive patients at HELP/PSI, Inc, an in-patient drug rehabilitation center, had a high baseline prevalence of Staphylococcus aureus colonization (49%) and incidence of infection (17%) in a previous year-long study...
  30. pmc Prospective investigation of nasal mupirocin, hexachlorophene body wash, and systemic antibiotics for prevention of recurrent community-associated methicillin-resistant Staphylococcus aureus infections
    Loren G Miller
    Harbor UCLA Medical Center, Torrance, California, USA
    Antimicrob Agents Chemother 56:1084-6. 2012
    ..We prospectively evaluated 31 patients with recurrent CA-MRSA skin infections who received nasal mupirocin, topical hexachlorophene body wash, and an oral anti-MRSA antibiotic...
  31. ncbi Risk factors for isolation of low-level mupirocin-resistant versus -susceptible methicillin-resistant Staphylococcus aureus from patients in intensive care units
    Dae Won Park
    Department of Internal Medicine, The Institute of Emerging Infectious Diseases, College of Medicine, Korea University, 126 1 Anam Dong 5th Street, Sungbuk Gu, Seoul 136 705, Republic of Korea
    J Infect 54:337-42. 2007
    The aim of this study was to determine the risk factors for the recovery of low-level mupirocin-resistant (mup(r)) or -susceptible (mup(s)) MRSA from patients in intensive care units (ICUs).
  32. pmc A model for evaluating topical antimicrobial efficacy against methicillin-resistant Staphylococcus aureus biofilms in superficial murine wounds
    Eric D Roche
    Research and Development, Healthpoint Biotherapeutics, Fort Worth, Texas, USA
    Antimicrob Agents Chemother 56:4508-10. 2012
    ..Common topical antimicrobial agents had reduced efficacy when treatment was initiated 24 h after inoculation compared to 4 h after inoculation. This model provides a rapid in vivo test for new agents to treat wound biofilm infections...
  33. ncbi Improved burns therapy: liposomes-in-hydrogel delivery system for mupirocin
    Julia Hurler
    Drug Transport and Delivery Research Group, Department of Pharmacy, Faculty of Health Sciences, University of Tromsø, Tromsø N 9037, Norway
    J Pharm Sci 101:3906-15. 2012
    ..b>Mupirocin-in-liposomes-in-hydrogels were proposed as advanced delivery system for improved burn therapy...
  34. ncbi Cost-effectiveness of preoperative nasal mupirocin treatment in preventing surgical site infection in patients undergoing total hip and knee arthroplasty: a cost-effectiveness analysis
    Xan F Courville
    Department of Orthopaedics, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Infect Control Hosp Epidemiol 33:152-9. 2012
    To perform a cost-effectiveness analysis to evaluate preoperative use of mupirocin in patients with total joint arthroplasty (TJA).
  35. ncbi Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase
    T Nakama
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 276:47387-93. 2001
    ..inhibits the isoleucyl-tRNA synthetases (IleRSs) from the three primary kingdoms, whereas the antibiotic mupirocin inhibits only the eubacterial and archaeal IleRSs, but not the eukaryotic enzymes, and therefore is clinically ..
  36. ncbi Treatment of chronic rhinosinusitis exacerbations due to methicillin-resistant Staphylococcus aureus with mupirocin irrigations
    C Arturo Solares
    The Cleveland Clinic Foundation, Head and Neck Institute, OH 44195, USA
    Am J Otolaryngol 27:161-5. 2006
    ..Treatment often involves intravenous antibiotics that provide only transient benefits. Mupirocin has well-recognized antistaphylococcal activity, and its nasal formulation is approved by the Food and Drug ..
  37. ncbi Catalytic asymmetric synthesis of a potent thiomarinol antibiotic
    Xuri Gao
    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada
    J Am Chem Soc 127:1628-9. 2005
    ..This key operation provides a rare example of an enantioselective HDA reaction involving acyclic 2-substituted enol ethers, and it featured an unusual but fortuitous kinetic selection that favored the requisite Z-dienophile...
  38. pmc In vivo transfer of high-level mupirocin resistance from Staphylococcus epidermidis to methicillin-resistant Staphylococcus aureus associated with failure of mupirocin prophylaxis
    Julian G Hurdle
    School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, UK
    J Antimicrob Chemother 56:1166-8. 2005
    We examined the molecular basis of the emergence of mupirocin resistance in a methicillin-resistant Staphylococcus aureus (MRSA) strain colonizing a nursing home resident undergoing mupirocin prophylaxis...
  39. pmc Virulence characteristic and MLST-agr genetic background of high-level mupirocin-resistant, MRSA isolates from Shanghai and Wenzhou, China
    Qingzhong Liu
    Department of Clinical Laboratory, Shanghai First People s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
    PLoS ONE 7:e37005. 2012
    The emergence and prevalence of high-level mupirocin-resistant, methicillin-resistant Staphylococcus aureus (MuH MRSA) is challenging the eradication of MRSA nasal carriage and the treatment of skin and soft tissue infections...
  40. ncbi Community-genotype strains of methicillin-resistant Staphylococcus aureus with high-level mupirocin resistance in a neonatal intensive care unit
    So Hyun Park
    Department of Pediatrics, St Vincent s Hospital, The Catholic University of Korea, Gyeonggi Do, Republic of Korea
    Early Hum Dev 89:661-5. 2013
    The aim of this study was to investigate the genotypes of mupirocin-resistant methicillin-resistant Staphylococcus aureus (MR-MRSA) isolates in our neonatal intensive care unit (NICU) and their potential source.
  41. ncbi Lack of efficacy of mupirocin in the prevention of infections with Staphylococcus aureus in liver transplant recipients and candidates
    David L Paterson
    Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Transplantation 75:194-8. 2003
    ..However, the role of decolonization with mupirocin applied intranasally for the prevention of S. aureus infections in these patients has not been determined.
  42. ncbi The emergence of mupirocin resistance among clinical isolates of methicillin-resistant Staphylococcus aureus in Trinidad: a first report
    Fitzroy A Orrett
    Department of Paraclinical Sciences, Unit of Pathology and Microbiology, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago, West Indies
    Jpn J Infect Dis 61:107-10. 2008
    The objective of the study was to investigate the trend of mupirocin resistance among methicillin-resistant Staphylococcus aureus (MRSA) in Trinidad...
  43. pmc Insights into physiological and genetic mupirocin susceptibility in bifidobacteria
    Fausta Serafini
    Department of Genetics, Biology of Microorganisms, Anthropology, and Evolution, University of Parma, Parco Area delle Scienze 11A, 43124 Parma, Italy
    Appl Environ Microbiol 77:3141-6. 2011
    b>Mupirocin is an antibiotic commonly used in selective media for the isolation of bifidobacteria. However, little is known about the genetic traits responsible for bifidobacterial resistance to mupirocin...
  44. ncbi Prophylaxis against Staphylococcus aureus vascular graft infection with mupirocin-soaked, collagen-sealed dacron
    R Ghiselli
    Department of General Surgery, INRCA IRRCS, University of Ancona, Ancona, Italy
    J Surg Res 99:316-20. 2001
    A rat model was used to investigate the efficacy of mupirocin in the prevention of vascular prosthetic graft infections...
  45. ncbi Does nasal colonization or mupirocin treatment affect recurrence of methicillin-resistant Staphylococcus aureus skin and skin structure infections?
    Joseph Rahimian
    Department of Infectious Diseases, St Vincent s Hospital, Manhattan, New York Medical College, New York, New York, USA
    Infect Control Hosp Epidemiol 28:1415-6. 2007
    ..We performed a retrospective study and determined that the presence of nasal colonization did not affect recurrence and nasal mupirocin treatment marginally decreased recurrence.
  46. pmc Mupirocin resistance in Staphylococcus aureus causing recurrent skin and soft tissue infections in children
    J Chase McNeil
    Department of Pediatrics, Baylor College of Medicine and Texas Children s Hospital, Feigin Center, Suite 1150, 1102 Bates St, Houston, TX 77030, USA
    Antimicrob Agents Chemother 55:2431-3. 2011
    Staphylococcus aureus resistance to mupirocin is often caused by acquisition of a novel isoleucyl-tRNA synthetase encoded on the plasmid gene mupA. We tested S...
  47. ncbi Mupirocin for preventing exit-site infection and peritonitis in patients undergoing peritoneal dialysis
    Gaosi Xu
    Department of Nephrology, Second Affiliated Hospital, Nanchang University, Nanchang, China
    Nephrol Dial Transplant 25:587-92. 2010
    Recently, there have been increasing concerns about the emergence of mupirocin resistance and increased infections due to lowered inhibition of Staphylococcus aureus...
  48. ncbi Phosphopantetheinylation and specificity of acyl carrier proteins in the mupirocin biosynthetic cluster
    Jennifer A Shields
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Chembiochem 11:248-55. 2010
    Acyl carrier proteins are vital for the biosynthesis of fatty acids and polyketides. The mupirocin biosynthetic cluster of Pseudomonas fluorescens encodes eleven type I ACPs embedded in its multifunctional polyketide synthase (PKS) ..
  49. pmc Topical mupirocin/sodium hypochlorite reduces peritonitis and exit-site infection rates in children
    Annabelle N Chua
    Department of Pediatrics, Renal Division, Houston, TX 77030, USA
    Clin J Am Soc Nephrol 4:1939-43. 2009
    ..The effect of topical mupirocin (Mup) and sodium hypochlorite (NaOCl) solution was evaluated as part of routine daily exit site care on ..
  50. pmc Amplification of the gene for isoleucyl-tRNA synthetase facilitates adaptation to the fitness cost of mupirocin resistance in Salmonella enterica
    Wilhelm Paulander
    Department of Microbiology, College of Biological Sciences, University of California, Davis, CA 95616, USA
    Genetics 185:305-12. 2010
    ..This adaptation process was studied in mupirocin-resistant (Mup(R)) strains of Salmonella enterica...
  51. ncbi Manipulation of quorum sensing regulation in Pseudomonas fluorescens NCIMB 10586 to increase mupirocin production
    Joanne Hothersall
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Appl Microbiol Biotechnol 90:1017-26. 2011
    Transcription of the 74 kb Pseudomonas fluorescens mupirocin [pseudomonic acid (PA)] biosynthesis cluster depends on quorum sensing-dependent regulation via the LuxI/LuxR homologues MupI/MupR...
  52. pmc Mupirocin and chlorhexidine resistance in Staphylococcus aureus in patients with community-onset skin and soft tissue infections
    Stephanie A Fritz
    Departments of Pediatrics, Washington University in St Louis School of Medicine, St Louis, Missouri, USA
    Antimicrob Agents Chemother 57:559-68. 2013
    Decolonization measures, including mupirocin and chlorhexidine, are often prescribed to prevent Staphylococcus aureus skin and soft tissue infections (SSTI)...
  53. ncbi A high prevalence of mupirocin and macrolide resistance determinant among Staphylococcus aureus strains isolated from burnt patients
    Shadi Shahsavan
    Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Burns 38:378-82. 2012
    ..The resistance rate to methicillin, erythromycin and mupirocin were 58.5%, 58% and 40%, respectively...
  54. pmc Molecular characterization of resistance to mupirocin in methicillin-susceptible and -resistant isolates of Staphylococcus aureus from nasal samples
    Fernando Chaves
    Servicio de Microbiologia, Hospital Universitario Doce de Octubre, Avenida de Cordoba sn, 28041 Madrid, Spain
    J Clin Microbiol 42:822-4. 2004
    A total of 15 of 101 (14.8%) nasal methicillin-resistant Staphylococcus aureus (MRSA) isolates exhibited mupirocin resistance (Mup(r)) compared with 1 of 154 (0.6%) methicillin-susceptible Staphylococcus aureus isolates...
  55. ncbi Mupirocin resistance after long-term use for Staphylococcus aureus colonization in patients undergoing chronic peritoneal dialysis
    Miguel Pérez-Fontán
    Division of Nephrology, Hospital Juan Canalejo, Coruna, Spain
    Am J Kidney Dis 39:337-41. 2002
    b>Mupirocin (Mup) has been used extensively to prevent Staphylococcus aureus (SAu) infections in patients undergoing peritoneal dialysis (PD)...
  56. pmc High-level mupirocin resistance within methicillin-resistant Staphylococcus aureus pandemic lineages
    Eduardo Pérez-Roth
    Unidad de Investigacion, Hospital Universitario Nuestra Senora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
    Antimicrob Agents Chemother 50:3207-11. 2006
    ..Here, we investigated the emergence of high-level mupirocin resistance (Hi-Mup(r))...
  57. pmc Clonal dissemination and mupA gene polymorphism of mupirocin-resistant Staphylococcus aureus isolates from long-term-care facilities in South Korea
    Jae Il Yoo
    Laboratory of Antimicrobial Resistant Pathogens, Department of Microbiology, National Institute of Health, KCDC, 194, Tonil Lo, Eunpyung Gu, Seoul 122 701, South Korea
    Antimicrob Agents Chemother 50:365-7. 2006
    We identified 25 high-level mupirocin-resistant (MuH) and 21 low-level mupirocin-resistant (MuL) Staphylococcus aureus isolates from eight long-term-care facilities (LTCFs)...
  58. ncbi Prevalence and mechanisms of low- and high-level mupirocin resistance in staphylococci isolated from a Korean hospital
    Hee Jeong Yun
    National Creative Research Initiatives Center for ARS Network, College of Pharmacy, Seoul National University, San 56 1, Shillim Dong, Kwanak gu, Seoul 151 742, Korea
    J Antimicrob Chemother 51:619-23. 2003
    b>Mupirocin has been used against Gram-positive pathogenic bacteria, and is a specific inhibitor of bacterial isoleucyl-tRNA synthetase...
  59. ncbi The antifungal activity of mupirocin
    R O Nicholas
    SmithKline Beecham Pharmaceuticals, Collegeville, PA 19426, USA
    J Antimicrob Chemother 43:579-82. 1999
    The antibacterial agent mupirocin (pseudomonic acid A) is used as a topical agent in the treatment of superficial infections by Gram-positive bacteria, particularly Staphylococcus aureus...
  60. ncbi Multiple mechanisms to ameliorate the fitness burden of mupirocin resistance in Salmonella typhimurium
    Wilhelm Paulander
    Department of Bacteriology, Swedish Institute for Infectious Disease Control and Microbiology, Tumor and Cell Biology Center, Karolinska Institute, S 171 82 Solna, Sweden
    Mol Microbiol 64:1038-48. 2007
    We examined how the fitness costs of mupirocin resistance caused by mutations in the chromosomal isoleucyl-tRNA synthetase gene (ileS) can be ameliorated...
  61. ncbi Increasing mupirocin resistance of Staphylococcus aureus in CAPD--should it continue to be used as prophylaxis?
    John M Conly
    Perit Dial Int 22:649-52. 2002
    This editorial summarizes the mechanisms of mupirocin resistance and the conditions that promote its development...
  62. pmc Investigation of the potential for mutational resistance to XF-73, retapamulin, mupirocin, fusidic acid, daptomycin, and vancomycin in methicillin-resistant Staphylococcus aureus isolates during a 55-passage study
    David J Farrell
    Quotient Bioresearch Limited, Newmarket Road, Fordham, Cambs CB75WW, United Kingdom
    Antimicrob Agents Chemother 55:1177-81. 2011
    ..55-passage) resistance selection studies in the presence of subinhibitory concentrations of XF-73, retapamulin, mupirocin, fusidic acid, and vancomycin against four Network on Antimicrobial Resistance in Staphylococcus aureus MRSA ..
  63. pmc Mupirocin resistance related to increasing mupirocin use in clinical isolates of methicillin-resistant Staphylococcus aureus in a pediatric population
    Jacob S Hogue
    Department of Pediatrics, Madigan Army Medical Center, Tacoma, Washington, USA
    J Clin Microbiol 48:2599-600. 2010
    ..proportion of methicillin-resistant Staphylococcus aureus (MRSA) isolates from pediatric patients demonstrating mupirocin resistance related to mupirocin use at our institution...
  64. ncbi Effectiveness of mupirocin and polymyxin B in experimental Staphylococcus aureus, Pseudomonas aeruginosa, and Serratia marcescens keratitis
    Judy M Moreau
    Department of Microbiology, Immunology, and Parasitology, LSU Health Sciences Center, New Orleans, LA 70112, USA
    Cornea 21:807-11. 2002
    The purpose of this study was to determine the effectiveness of mupirocin and polymyxin B, alone and in combination, in vitro and in vivo using rabbit models of, and keratitis.
  65. ncbi Treatment of Staphylococcus aureus colonization and prophylaxis for infection with topical intranasal mupirocin: an evidence-based review
    Kevin B Laupland
    Department of Medicine, University of Calgary and the Calgary Health Region, Calgary, Alberta, Canada
    Clin Infect Dis 37:933-8. 2003
    ..We critically appraised the published evidence regarding the efficacy of intranasal mupirocin for eradication of S. aureus nasal carriage and for prophylaxis of infection...
  66. pmc Nasal decolonization of Staphylococcus aureus with mupirocin: strengths, weaknesses and future prospects
    T Coates
    University College London, London, UK
    J Antimicrob Chemother 64:9-15. 2009
    ..UK guidelines recommend the use of mupirocin for nasal decolonization in certain groups of patients colonized with methicillin-resistant S. aureus (MRSA)...
  67. ncbi Mupirocin-resistant, methicillin-resistant Staphylococcus aureus: does mupirocin remain effective?
    Elaine S Walker
    James H Quillen Veterans Affairs Hospital, James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614, USA
    Infect Control Hosp Epidemiol 24:342-6. 2003
    To determine the efficacy of mupirocin ointment in reducing nasal colonization with mupirocin-susceptible, methicillin-resistant Staphylococcus aureus (MS MRSA) as well as mupirocin-resistant MRSA (MR MRSA).
  68. ncbi First report of clinical and microbiological failure in the eradication of glycopeptide-intermediate methicillin-resistant Staphylococcus aureus carriage by mupirocin
    J W Decousser
    Department of Hospital Health, Centre Hospitalier de Versailles, 177 rue de Versailles, 78157, Le Chesnay Cedex, France
    Eur J Clin Microbiol Infect Dis 22:318-9. 2003
  69. pmc New quadriplex PCR assay for detection of methicillin and mupirocin resistance and simultaneous discrimination of Staphylococcus aureus from coagulase-negative staphylococci
    Kunyan Zhang
    Center for Antimicrobial Resistance, Calgary Health Region Calgary Laboratory Services University of Calgary, Alberta, Canada T2L 2K8
    J Clin Microbiol 42:4947-55. 2004
    ..Multiplex PCR assays have been developed for the detection of methicillin- and mupirocin-resistant S. aureus and CoNS but not for the simultaneous discrimination of S. aureus from CoNS...
  70. doi Surveillance for mupirocin resistance among methicillin-resistant Staphylococcus aureus clinical isolates
    Kanokporn Mongkolrattanothai
    Infect Control Hosp Epidemiol 29:993-4. 2008
  71. ncbi Shift to Pseudomonic acid B production in P. fluorescens NCIMB10586 by mutation of mupirocin tailoring genes mupO, mupU, mupV, and macpE
    Sian M Cooper
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    Chem Biol 12:825-33. 2005
    b>Mupirocin, a polyketide-derived antibiotic from Pseudomonas fluorescens NCIMB10586, is a mixture of pseudomonic acids (PA) that target isoleucyl-tRNA synthase...
  72. ncbi Prevalence of clinical meticillin-resistant Staphylococcus aureus (MRSA) with high-level mupirocin resistance in Shanghai and Wenzhou, China
    Qing Zhong Liu
    Department of Clinical Microbiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
    Int J Antimicrob Agents 35:114-8. 2010
    ..from Shanghai and Wenzhou in China were subjected to a screening test by disk diffusion for detection of mupirocin resistance. Among the 803 strains, 53 (6.6%) were mupirocin-resistant...
  73. pmc Can mupirocin prevent methicillin-resistant Staphylococcus aureus infections?
    Heiman F L Wertheim
    Department of Medical Microbiology and Infectious Disease, Erasmus MC, Rotterdam, The Netherlands
    Crit Care 9:257-8. 2005
    In a retrospective study, Dr Muller and colleagues have assessed the efficacy of mupirocin nasal ointment alongside hygienic measures in methicillin-resistant Staphylococcus aureus (MRSA)-positive patients admitted to the intensive care ..
  74. ncbi Decrease in the incidence of mupirocin resistance among methicillin-resistant Staphylococcus aureus in carriers from an intensive care unit
    Juliana Caierão
    Fundacao Faculdade Federal de Ciencias Medicas de Porto Alegre
    Am J Infect Control 34:6-9. 2006
    Methicillin-resistant Staphylococcus aureus (MRSA) is a serious nosocomial problem, globally distributed. Decolonization with mupirocin can be used to control its dissemination.
  75. pmc Multiplex PCR for simultaneous identification of Staphylococcus aureus and detection of methicillin and mupirocin resistance
    E Perez-Roth
    Molecular Biology Laboratory, Research Unit, Nuestra Señora de Candelaria Hospital, Santa Cruz de Tenerife, Spain
    J Clin Microbiol 39:4037-41. 2001
    ..456-, and 651-bp regions of the mecA (encoding high-level methicillin resistance), ileS-2 (encoding high-level mupirocin resistance), and femB (encoding a factor essential for methicillin resistance) genes, respectively, from a ..
  76. ncbi Perioperative intranasal mupirocin for the prevention of surgical-site infections: systematic review of the literature and meta-analysis
    Alexander J Kallen
    VA Outcomes Group, VA Medical Center, White River Junction, VT 05009, USA
    Infect Control Hosp Epidemiol 26:916-22. 2005
    To review the evidence evaluating perioperative intranasal mupirocin for the prevention of surgical-site infections according to type of surgical procedure.
  77. ncbi Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by pseudomonas fluorescens: pseudomonic acid B biosynthesis precedes pseudomonic acid A
    Joanne Hothersall
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Biol Chem 282:15451-61. 2007
    The Pseudomonas fluorescens mupirocin biosynthetic cluster encodes six proteins involved in polyketide biosynthesis and 26 single polypeptides proposed to perform largely tailoring functions...
  78. ncbi How does Pseudomonas fluorescens avoid suicide from its antibiotic pseudomonic acid?: Evidence for two evolutionarily distinct isoleucyl-tRNA synthetases conferring self-defense
    Tatsuo Yanagisawa
    Department of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464 8602, Japan
    J Biol Chem 278:25887-94. 2003
    ..synthetases (IleRSs) encoded by two distinct genes (ileS1 and ileS2) were identified in pseudomonic acid (mupirocin)-producing Pseudomonas fluorescens...
  79. ncbi Mupirocin resistance among Iranian isolates of Staphylococcus aureus
    Horieh Saderi
    Dept of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran
    Med Sci Monit 14:BR210-3. 2008
    The topical agent mupirocin plays a crucial role in strategies designed to control outbreaks of methicillin-resistant Staphylococcus aureus. The rate of high- and low-level mupirocin resistance among S...
  80. ncbi In vitro activity of retapamulin against Staphylococcus aureus isolates resistant to fusidic acid and mupirocin
    N Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, HPA Centre for Infections, London NW9 5EQ, UK
    J Antimicrob Chemother 62:766-8. 2008
    We determined the in vitro activity of retapamulin, a novel pleuromutilin antibiotic, against 664 Staphylococcus aureus isolates from the UK, including many resistant to fusidic acid and/or highly resistant to mupirocin.
  81. ncbi Risk factors associated with mupirocin resistance in meticillin-resistant Staphylococcus aureus
    A R Caffrey
    Veterans Affairs Medical Center, Infectious Diseases Research Program, Providence, Rhode Island, USA
    J Hosp Infect 76:206-10. 2010
    ..Staphylococcus aureus (MRSA) decolonisation programmes has been increasing and the emergence of mupirocin resistance has been reported...
  82. ncbi The isoleucyl-tRNA synthetase mutation V588F conferring mupirocin resistance in glycopeptide-intermediate Staphylococcus aureus is not associated with a significant fitness burden
    Julian G Hurdle
    Antimicrobial Research Centre and Division of Microbiology, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
    J Antimicrob Chemother 53:102-4. 2004
    Failure to eradicate nasal carriage of a glycopeptide-intermediate Staphylococcus aureus (strain GISA-2) with mupirocin was recently attributed to a mutation that confers low-level mupirocin resistance...
  83. ncbi Methicillin-resistant Staphylococcus aureus whole-body decolonization among hospitalized patients with variable site colonization by using mupirocin in combination with octenidine dihydrochloride
    U Rohr
    Division of Hygiene, University Hospital, Bergmannsheil Bochum, Burkle de la Camp Platz 1, D 44789 Bochum, Germany
    J Hosp Infect 54:305-9. 2003
    ..Decolonization was performed by intranasal application of mupirocin, combined with an octenidine dihydrochloride bodywash over a period of five days...
  84. ncbi Long-term efficacy of mupirocin in the prevention of infections with meticillin-resistant Staphylococcus aureus in a gastroenterology unit
    C Dupeyron
    Service de Bactériologie Virologie Hygiène, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
    J Hosp Infect 63:385-92. 2006
    ..efficacy (55 months) of eradication of nasal carriage of meticillin-resistant Staphylococcus aureus (MRSA) by mupirocin was assessed for MRSA infections in a gastroenterology unit receiving patients for long hospital stays...
  85. ncbi Intranasal mupirocin for reduction of Staphylococcus aureus infections in surgical patients with nasal carriage: a systematic review
    Miranda M L Van Rijen
    Laboratory for Microbiology and Infection Control, Amphia Hospital, Location Molengracht, PO Box 90158, 4800 RK Breda, The Netherlands
    J Antimicrob Chemother 61:254-61. 2008
    ..The objective of this review was to assess whether intranasal mupirocin treatment of nasal S. aureus carriers before surgery results in a reduction of the post-operative S...
  86. pmc Mupirocin-resistant, methicillin-resistant Staphylococcus aureus strains in Canadian hospitals
    Andrew E Simor
    Department of Microbiology, Sunnybrook Health Sciences Centre, B103 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
    Antimicrob Agents Chemother 51:3880-6. 2007
    b>Mupirocin resistance in Staphylococcus aureus is increasingly being reported in many parts of the world. This study describes the epidemiology and laboratory characterization of mupirocin-resistant methicillin-resistant S...
  87. ncbi Mupirocin resistance in patients colonized with methicillin-resistant Staphylococcus aureus in a surgical intensive care unit
    Jeffrey C Jones
    Division of Infectious Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Infect Dis 45:541-7. 2007
    ..Staphylococcus aureus (MRSA) can be a precursor to serious infection, and decolonization with topical mupirocin has been studied as a means of preventing clinical infection...
  88. ncbi Impact of treating Staphylococcus aureus nasal carriers on wound infections in cardiac surgery
    A Konvalinka
    Division of Internal Medicine, University of Toronto, Toronto, Ontario, Canada
    J Hosp Infect 64:162-8. 2006
    ..Treatment with mupirocin can eradicate the organism in the short term, and prophylactic treatment of colonized patients may prevent ..
  89. ncbi Folliculitis decalvans: successful treatment with a combination of rifampicin and topical mupirocin
    Sukhjot Kaur
    J Dermatol 29:180-1. 2002
  90. pmc Molecular analysis of isoleucyl-tRNA synthetase mutations in clinical isolates of methicillin-resistant Staphylococcus aureus with low-level mupirocin resistance
    Jin Ah Yang
    Research Institute of Emerging Infectious Diseases, Korea University, Seoul, Korea
    J Korean Med Sci 21:827-32. 2006
    Emergence and spread of low-level mupirocin resistance in staphylococci have been increasingly reported in recent years...
  91. ncbi Success of MRSA eradication in hospital routine: depends on compliance
    D Hansen
    Hospital Hygiene, University Hospital Essen, Hufelandstr 55, 45122 Essen, Germany
    Infection 35:260-4. 2007
    ..We wanted to assess the effectiveness of MRSA eradication procedures--especially octenidine whole body washings and mupirocin nasal ointment--under conditions of everyday life.
  92. ncbi Interpretive criteria for mupirocin susceptibility testing of Staphylococcus spp. using CLSI guidelines
    S Creagh
    Department of Medical Microbiology, Cork University Hospital, Wilton, Cork, Ireland
    Br J Biomed Sci 64:1-5. 2007
    b>Mupirocin is an antimicrobial agent commonly used to treat staphylococcal infection or to eliminate persistent carriage...
  93. ncbi Preoperative use of mupirocin for the prevention of healthcare-associated Staphylococcus aureus infections: a cost-effectiveness analysis
    Lisa S Young
    Department of Medicine, University of California, San Francisco, CA, USA
    Infect Control Hosp Epidemiol 27:1304-12. 2006
    Staphylococcus aureus is the most common cause of healthcare-associated infections. Intranasal mupirocin treatment probably decreases S. aureus infections among colonized surgical patients...
  94. ncbi Randomized controlled trial of chlorhexidine gluconate for washing, intranasal mupirocin, and rifampin and doxycycline versus no treatment for the eradication of methicillin-resistant Staphylococcus aureus colonization
    Andrew E Simor
    University of Toronto, and Dept of Microbiology, Sunnybrook Health Sciences Centre, Toronto, M4N 3M5, Canada
    Clin Infect Dis 44:178-85. 2007
    ..Eradication of methicillin-resistant Staphylococcus aureus (MRSA) carriage may reduce the risk of MRSA infection and prevent transmission of the organism to other patients...
  95. ncbi Mupirocin resistance in Staphylococcus aureus in an Indian hospital
    Ravisekhar Gadepalli
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi 29, India
    Diagn Microbiol Infect Dis 58:125-7. 2007
    Two hundred Staphylococcus aureus strains collected from an Indian hospital were tested for mupirocin susceptibility using disc diffusion method and E-test...
  96. ncbi Surveillance for mupirocin resistance following introduction of routine peri-operative prophylaxis with nasal mupirocin
    W N Fawley
    Department of Microbiology and Infection Control, Leeds Teaching Hospitals and University of Leeds, Leeds, UK
    J Hosp Infect 62:327-32. 2006
    ..have previously described the successful use of a five-day peri-operative prophylaxis regimen using nasal mupirocin and topical triclosan (PPNMTT) to prevent methicillin-resistant Staphylococcus aureus (MRSA) infection...
  97. ncbi Synergistic effects of mupirocin and an isoflavanone isolated from Erythrina variegata on growth and recovery of methicillin-resistant Staphylococcus aureus
    Masaru Sato
    Department of Oral Pathology, Asahi University School of Dentistry, 1851 Hozumi, Mizuho, Gifu 501 0296, Japan
    Int J Antimicrob Agents 24:241-6. 2004
    ..13-6.25mg/l, while MICs of mupirocin were 0.20-3.13 mg/l...
  98. ncbi In vitro activity of linezolid, quinupristin-dalfopristin, vancomycin, teicoplanin, moxifloxacin and mupirocin against methicillin-resistant Staphylococcus aureus: comparative evaluation by the E test and a broth microdilution method
    Jochen Abb
    Institute of Microbiology, Klinikum Ludwigsburg, Posilipostrasse 4, D 71640, Ludwigsburg, Germany
    Diagn Microbiol Infect Dis 43:319-21. 2002
    ..6 percent) were resistant to the topical agent mupirocin. Linezolid and quinupristin-dalfopristin may prove useful alternatives for the treatment of patients with MRSA ..
  99. ncbi Decolonization of methicillin-resistant Staphylococcus aureus using oral vancomycin and topical mupirocin
    B Maraha
    Department of Medical Microbiology, St Elisabeth Hospital, PO Box 747, 5000 AS Tilburg, The Netherlands
    Clin Microbiol Infect 8:671-5. 2002
    ..of this study was to assess the efficacy and safety of a short course of oral vancomycin and intranasal mupirocin ointment in the eradication of methicillin-resistant Staphylococcus aureus (MRSA) colonization...
  100. ncbi Survey of high- and low-level mupirocin-resistant strains of methicillin-resistant Staphylococcus aureus in 15 Japanese hospitals
    Shigeru Fujimura
    Department of Microbiology, Miyagi University, Miyagi, Japan
    Chemotherapy 49:36-8. 2003
    The extent of mupirocin-resistant methicillin-resistant Staphylococcus aureus (MRSA) in countries using mupirocin only for the eradication of nasal carriage of MRSA is unknown.
  101. ncbi Characterization of the mupirocin biosynthesis gene cluster from Pseudomonas fluorescens NCIMB 10586
    A Kassem El-Sayed
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    Chem Biol 10:419-30. 2003
    The polyketide antibiotic mupirocin (pseudomonic acid) produced by Pseudomonas fluorescens NCIMB 10586 competitively inhibits bacterial isoleucyl-tRNA synthase and is useful in controlling Staphylococcus aureus, particularly methicillin-..

Research Grants25

  1. Antimicrobial Lipids within the Oral Cavity
    PHILIP WESLEY WERTZ; Fiscal Year: 2010
    ..ethanol and is capable of killing an isolate of Staphylococcus aureus that is resistant to both methicillin and mupirocin. The proposed studies are designed to better develop our understanding and ability to exploit these natural ..
  2. Project CLEAR - Changing Lives by Eradicating Antibiotic Resistance
    Susan S Huang; Fiscal Year: 2012
    ..We hypothesize that serial decolonization of MRSA carriers with nasal mupirocin, oral chlorhexidine rinses, and chlorhexidine body wash will significantly reduce inpatient and outpatient MRSA ..
  3. Decreasing Bioburden to Reduce Healthcare-Associated Infections and Readmissions
    Susan S Huang; Fiscal Year: 2013
    ..care units (ICUs) indicate that decolonization of patients'skin with chlorhexidine, and nares with mupirocin can prevent many HAIs...
  4. Nitric Oxide-Releasing Intranasal Gel To Decolonize Biofilm-embedded S. Aureus
    SUSANNE BAUMAN; Fiscal Year: 2012
    ..The only FDA-approved treatment for nasal decolonization of S. aureus is 2% mupirocin. Clinical studies have shown that nasal decolonization decreases the number of infections contracted by S...
  5. EPIDEMIOLOGY AND ERADICATION OF MRSA IN HOUSEHOLDS WITH CHILDREN
    STEPHANIE ANN FRITZ; Fiscal Year: 2013
    ..into an intervention study to compare the effectiveness of decolonization measures (application of nasal mupirocin and dilute bleach water baths) in preventing recurrent SSTI when these measures are performed by all household ..
  6. Epicenters III: Translational Research to Prevent Healthcare Associated Infection
    Richard Platt; Fiscal Year: 2013
    ..2) We will assess the potential utility of retapamulin for topical decolonization when mupirocin resistance makes the latter agent unusable...
  7. Staphylococcus aureus resistance to topical antimicrobial agents in children
    JONATHON CHASE MCNEIL; Fiscal Year: 2013
    ..aureus bacteremia as well as other forms of invasive disease. Mupirocin is a topical antibiotic used for treatment of superficial skin-and-soft-tissue infections (SSTI) due to gram-..
  8. A Randomized Clinical Trial to Prevent Recurrent CA-MRASA Infection
    Loren Miller; Fiscal Year: 2009
    ..trial, all subjects will be randomized in a 2 x 2 design to test: 1) chlorhexidine body washes plus nasal mupirocin ointment vs. usual care, and 2) environmental cleansing with ethanol spray and aggressive laundering vs...
  9. Implementation and Effectiveness of a S. aureus Surgical Site Infection Preventio
    Loreen A Herwaldt; Fiscal Year: 2013
    ..hospitals can use to facilitate bundle implementation;4) Determine whether the bundle increases the number of mupirocin-resistant or CHG-resistant S. aureus isolates...
  10. Hospital-Acquired Mupirocin-Resistant MRSA in Post-Partum Women and Newborns
    SHARON BETH BRODIE WRIGHT; Fiscal Year: 2013
    ..Resistance to mupirocin was noted in a large proportion of isolates during the outbreak, which was an unusual and unexpected finding...
  11. Human Microbiome and Healthcare Associated Infections
    Mary Claire Roghmann; Fiscal Year: 2013
    ..A recent meta-analysis reported that decolonization with intranasal mupirocin, a Gram-positive antimicrobial agent, increases the risk of infections due to organisms other than S...
  12. Impact of MRSA Decolonization Therapy on MRSA Infection and Transmission
    Arch G Mainous; Fiscal Year: 2012
    ..By using both randomization and a double-blind, placebo-control for mupirocin decolonization we are better assured that any differences between the two groups can be attributed to the ..
  13. Metagenomic Studies of MRSA Colonization
    Mary Claire Roghmann; Fiscal Year: 2013
    ..A recent Cochrane meta-analysis showed that decolonization with intranasal mupirocin, a Gram-positive antimicrobial agent, increases the risk of infections due to organisms other than S...
  14. NASAL COLONIZATION BY S AUREUS--MECHANISMS AND IMMUNITY
    Jean Lee; Fiscal Year: 2003
    ..Attenuation of carriage with the antibiotic mupirocin has been shown to reduce the prevalence of infection in certain high-risk groups...
  15. THE CLOUD ADULT
    Robert Sherertz; Fiscal Year: 2003
    ..aureus in the nose and using topical mupirocin to reduce the number of S.aureus in the nose. Specific Aim 3 will determine the prevalence of single nasal S...
  16. Nisin-based topical formulation for treatment of anthrax
    John Kokai Kun; Fiscal Year: 2003
    ..The final product is intended to minimize the danger for those exposed to B. anthracis and should also be effective for disinfection of other bioterrorism agents and for nosocomial pathogens in the healthcare setting. ..
  17. THE SIGNIFICANCE OF FUNGURIA IN HOSPITALIZED PATIENTS
    Loren Miller; Fiscal Year: 2004
    ....
  18. Antiretroviral Therapy of AIDS-Related Kaposi's Sarcoma in Africa
    Jeffrey Martin; Fiscal Year: 2009
    ..Findings from this work will both help to inform clinical care of patients with AIDS-related KS in Africa and provide biological insights into the effect of antiretroviral therapy on underlying KSHV infection. ..
  19. Cardiovascular Disease and Diabetic Nephropathy
    Rajnish Mehrotra; Fiscal Year: 2008
    ..The applicant has institutional support and a career development plan including obtaining a Masters in Clinical Investigation, to achieve his career goals. ..
  20. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Saiman; Fiscal Year: 2009
    ..Carefully conducted observational studies and clinically relevant in vitro antimicrobial susceptibility testing, hold the greatest promise to improve the treatment of patients infected with mutidrug-resistant organisms. ..
  21. HEMODIALYSIS VASCULAR ACCESS CLINICAL TRIALS CONSORTIUM
    Michael Allon; Fiscal Year: 2007
    ..The primary endpoint will be fistula thrombosis within 6 weeks, and the secondary endpoint will be the ability to use the fistula successfully for dialysis within 6 months. ..
  22. Vascular Access in Hemodialysis Patients
    Michael Allon; Fiscal Year: 2005
    ..The applicant will assist the trainees in acquiring the conceptual skills, research experience, and motivation required to pursue a successful career in Academic Nephrology. ..
  23. Device use in Nursing Homes: Reducing Risk of Infection
    Lona Mody; Fiscal Year: 2007
    ..abstract_text> ..