Genomes and Genes
Summary: 10-carbon saturated monocarboxylic acids.
Publications188 found, 100 shown here
- Activation of two different resistance mechanisms in Saccharomyces cerevisiae upon exposure to octanoic and decanoic acidsJ L Legras
UMR 1083 Sciences pour l Oenologie INRA, SupAgro, Montpellier Cedex 1, France
Appl Environ Microbiol 76:7526-35. 2010Medium-chain fatty acids (octanoic and decanoic acids) are well known as fermentation inhibitors...
- Strain improvement of Streptomyces roseosporus for daptomycin production by rational screening of He-Ne laser and NTG induced mutants and kinetic modelingGuanghai Yu
Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, People s Republic of China
Appl Biochem Biotechnol 163:729-43. 2011..It was concluded that the method of rational screening of He-Ne Laser and NTG-induced mutants could efficiently improve the daptomycin production ability of S. roseosporus...
- Postconditioning effect of granulocyte colony-stimulating factor is mediated through activation of risk pathway and opening of the mitochondrial KATP channelsShohei Sumi
Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan
Am J Physiol Heart Circ Physiol 299:H1174-82. 2010....
- Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brainR Bajgar
Department of Biochemistry and Molecular Biology, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, Oregon 97006-8921, USA
J Biol Chem 276:33369-74. 2001..Three independent methods indicate that brain mitochondria contain six to seven times more mitoK(ATP) per milligram of mitochondrial protein than liver or heart...
- KATP channel openers have opposite effects on mitochondrial respiration under different energetic conditionsMatthias L Riess
Anesthesiology Research Laboratories, Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
J Cardiovasc Pharmacol 51:483-91. 2008..Therefore, the effects of mKATP channel openers on mitochondrial function likely depend on the experimental conditions and the cell's underlying energetic state...
- Mitochondria are targets for geranylgeranylacetone-induced cardioprotection against ischemia-reperfusion in the rat heartTetsuji Shinohara
Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
Am J Physiol Heart Circ Physiol 293:H1892-9. 2007..These processes may involve opening of the mitoK(ATP) channel...
- K(ATP) channel-independent targets of diazoxide and 5-hydroxydecanoate in the heartPeter J Hanley
Institut fur Normale und Pathologische Physiologie, Universitat Marburg, Deutschhausstrasse 2, 35037 Marburg, Germany
J Physiol 542:735-41. 2002..We propose that pharmacological preconditioning may be related to partial inhibition of respiratory chain complexes...
- Preconditioning limits mitochondrial Ca(2+) during ischemia in rat hearts: role of K(ATP) channelsL Wang
Division of Cardiovascular Medicine, University of California, Davis 95616, USA
Am J Physiol Heart Circ Physiol 280:H2321-8. 2001..These data suggest that the lowering of mitochondrial calcium overload is a mechanism of cardioprotection in PC...
- Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?Derek J Hausenloy
The Hatter Institute for Cardiovascular Studies, Center for Cardiology, University College London Hospitals and Medical School, Grafton Way, UK
Cardiovasc Res 55:534-43. 2002..We propose that ischemic preconditioning (IPC) and mitochondrial K(ATP) channel activation protect the myocardium by inhibiting mitochondrial permeability transition pore (MPTP) opening at reperfusion...
- In vitro killing of Candida albicans by fatty acids and monoglyceridesG Bergsson
Institute of Biology, University of Iceland, Reykjavik, Iceland
Antimicrob Agents Chemother 45:3209-12. 2001..Lauric acid, a 12-carbon saturated fatty acid, was the most active at lower concentrations and after a longer incubation time...
- Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathwaysXi Ming Yang
Department of Physiology, University of South Alabama, College of Medicine, Mobile 36688, USA
J Am Coll Cardiol 44:1103-10. 2004..An in situ model was used to test whether and how multiple occlusions at reperfusion can protect rabbit myocardium...
- KATP channel openers facilitate glutamate uptake by GluTs in rat primary cultured astrocytesXiu Lan Sun
Laboratory of Neuropharmacology, Department of Anatomy, Histology and Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, PR China
Neuropsychopharmacology 33:1336-42. 2008..Therefore, the present study not only reveals a novel pharmacological profile of KCOs as regulators of GluTs, but also provides a new strategy for neuroprotection...
- Pharmacologic characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activityG J Grover
Metabolic and Cardiovascular Diseases Drug Discovery, Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, New Jersey 08534-4000, USA
J Pharmacol Exp Ther 297:1184-92. 2001..Agents like BMS-191095 may owe their cardioprotective selectivity to selective mitochondrial K(ATP) activation...
- Desflurane-induced preconditioning alters calcium-induced mitochondrial permeability transitionVincent Piriou
Departement d Anesthesie Reanimation, Centre Hospitalier Lyon Sud, Pierre Benite, France
Anesthesiology 100:581-8. 2004..This study aimed at examining the effect of anesthetic preconditioning on mitochondrial permeability transition (MPT) pore opening...
- K+-independent actions of diazoxide question the role of inner membrane KATP channels in mitochondrial cytoprotective signalingStefan Dröse
Zentrum der Biologischen Chemie, Molekulare Bioenergetik, Universitatsklinikum Frankfurt, Haus 26, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
J Biol Chem 281:23733-9. 2006....
- Intestinal ischemia preconditions myocardium: role of protein kinase C and mitochondrial K(ATP) channelYou Ping Wang
First Department of Surgery, Kagawa Medical University, 1750 1, Ikenobe, Miki, Kita, Japan
Cardiovasc Res 55:576-82. 2002....
- Opening of mitochondrial ATP-sensitive potassium channels is a trigger of 3-nitropropionic acid-induced tolerance to transient focal cerebral ischemia in ratsTakashi Horiguchi
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
Stroke 34:1015-20. 2003....
- Mitochondrial potassium ATP channels and retinal ischemic preconditioningSteven Roth
Department of Anesthesia and Critical Care, University of Chicago, Illinois 60637, USA
Invest Ophthalmol Vis Sci 47:2114-24. 2006..To examine the mechanisms of ischemic preconditioning (IPC) related to the opening of mitochondrial KATP (mKATP) channels in the retina...
- Ischemic preconditioning protection against stunning in conscious diabetic sheep: role of glucose, insulin, sarcolemmal and mitochondrial KATP channelsHector F del Valle
Department of Physiology, Pharmacology and Biochemistry, Favaloro University, Buenos Aires, Argentina
Cardiovasc Res 55:642-59. 2002..However, these structures appear to be altered in diabetes and thus, it would be possible that preconditioning does not develop in diabetic hearts...
- Preconditioning with sevoflurane reduces changes in nicotinamide adenine dinucleotide during ischemia-reperfusion in isolated hearts: reversal by 5-hydroxydecanoic acidMatthias L Riess
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA
Anesthesiology 98:387-95. 2003..The authors tested if effects of APC on NADH concentrations before, during, and after ischemia are reversible by 5-hydroxydecanoate (5-HD), a putative mitochondrial K channel blocker...
- The relative order of mK(ATP) channels, free radicals and p38 MAPK in preconditioning's protective pathway in rat heartYuankun Yue
Department of Cell Biology and Neuroscience, MSB 2342, University of South Alabama, College of Medicine, Mobile 36688, USA
Cardiovasc Res 55:681-9. 2002..In addition, we tested whether protection from anisomycin, a p38 MAPK activator, is dependent on ROS production...
- Mitochondrial KATP channel-dependent and -independent phases of ischemic preconditioning against myocardial infarction in the ratYukinaga Nozawa
Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, South 1 West 16, Chuo Ku, Japan
Basic Res Cardiol 98:50-8. 2003....
- Diazoxide protects against methylmalonate-induced neuronal toxicityAlicia J Kowaltowski
Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP 05508 900, Brazil
Exp Neurol 201:165-71. 2006..These results uncover new potential neuroprotective effects of mitoK(ATP) agonists under situations in which oxidative phosphorylation is inhibited...
- P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit heartsOlaf Oldenburg
Department of Physiology, University of South Alabama, College of Medicine, Mobile, AL 36688, USA
J Mol Cell Cardiol 35:1035-42. 2003..7 +/- 9.5% and 27.7 +/- 4.6% infarction, respectively; P = n.s. vs. untreated hearts). These data provide strong evidence that P1075 does open mitoK(ATP) channels and protects the ischemic rabbit heart in a mitoK(ATP)-dependent manner...
- Isoflurane and sevoflurane during reperfusion prevent recovery from ischaemia in mitochondrial KATP channel blocker pretreated heartsK Masui
University of Yamanashi, Faculty of Medicine, Department of Anesthesiology, Yamanashi, Japan
Eur J Anaesthesiol 23:123-9. 2006..Thus, we investigated whether 5-hydroxydecanoate, a putative mitochondrial potassium channel blocker, prevents the cardioprotective effect of volatile anaesthetics...
- Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effectsJason Peart
Heart Foundation Research Centre, School of Health Science, Griffith University Gold Coast Campus, Queensland 4217, Southport, Australia
Cardiovasc Res 58:589-601. 2003..Signaling in adenosine-mediated preconditioning is controversial. We examined roles of mitochondrial (mito) K(ATP) channels, protein kinase C (PKC) and nitric oxide (NO)...
- Short-term caloric restriction improves ischemic tolerance independent of opening of ATP-sensitive K+ channels in both young and aged heartsKen Shinmura
Division of Geriatric Medicine, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
J Mol Cell Cardiol 39:285-96. 2005..In conclusion, short-term CR improves myocardial ischemic tolerance independent of the opening of KATP channels in both Y and O. CR-induced cardioprotection is associated with an increase in activated AMPK...
- Lack of manifestations of diazoxide/5-hydroxydecanoate-sensitive KATP channel in rat brain nonsynaptosomal mitochondriaTatiana Brustovetsky
Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Dr, Medical Science Building 549, Indianapolis, IN 46202, USA
J Physiol 568:47-59. 2005..Moreover, bongkrekic acid, another inhibitor of the ANT, inhibited K+ efflux similarly to ATP. These observations implicate the ANT in ATP-sensitive K+ transport in brain mitochondria...
- Mitochondria-derived reactive oxygen species and vascular MAP kinases: comparison of angiotensin II and diazoxideShoji Kimura
Department of Pharmacology, Kagawa University Medical School, 1750 1 Ikenobe, Miki, Kagawa 761 0793, Japan
Hypertension 45:438-44. 2005....
- Inhibition of phenylephrine induced hypertrophy in rat neonatal cardiomyocytes by the mitochondrial KATP channel opener diazoxideYing Xia
Department of Physiology and Pharmacology, University of Western Ontario, Medical Sciences Building, London, Ont, Canada N6A 5C1
J Mol Cell Cardiol 37:1063-7. 2004..Mitochondrial K(ATP) channel activation could represent an effective approach to minimize the myocardial hypertrophic process...
- Calcium-activated potassium channel triggers cardioprotection of ischemic preconditioningChun mei Cao
Department of Physiology, 4 F, Laboratory Block, Faculty of Medicine Building, The University of Hong Kong, 21 Sassoon Road, Hong Kong SAR, China
J Pharmacol Exp Ther 312:644-50. 2005..In conclusion, the study provides evidence that the K(Ca) channel triggers cardioprotection of IPC, which involves mPTP...
- Activation of mitochondrial ATP-sensitive potassium channels delays ischemia-induced cellular uncoupling in rat heartYue Liang Shen
Department of Physiology, Zhejiang University School of Medicine, Hangzhou 310031, China
Acta Pharmacol Sin 25:22-8. 2004..To test the hypothesis that cellular uncoupling induced by myocardial ischemia is mediated by activation of mitochondrial ATP-sensitive potassium channels (mitoKATP)...
- Ischemic preconditioning prevents reperfusion heart injury in cardiac hypertrophy by activation of mitochondrial KATP channelsKatare Gopalrao Rajesh
Department of Surgery II, Kochi Medical School, Kohasu, Oko cho, Nankoku, Kochi, Japan
Int J Cardiol 96:41-9. 2004..In this study we have demonstrated the role of ischemic preconditioning (IP) in preventing the reperfusion injury of the hypertrophied heart by activation of the depleted K(ATP) channels...
- Effect of classic preconditioning and diazoxide on endothelial function and O2- and NO generation in the post-ischemic guinea-pig heartAndrzej Beresewicz
Department of Clinical Physiology, Medical Centre of Postgraduate Education, 01 813 Warsaw, Poland
Cardiovasc Res 63:118-29. 2004....
- The direct physiological effects of mitoK(ATP) opening on heart mitochondriaAlexandre D T Costa
Dept of Biology, Portland State Univ, PO Box 751, Portland, OR 97207, USA
Am J Physiol Heart Circ Physiol 290:H406-15. 2006..These results provide decisive support for the hypothesis that mitochondria contain an ATP-sensitive K+ channel and establish the physiological consequences of mitoK(ATP) opening for mitochondria...
- Delayed preconditioning of the human myocardium: signal transduction and clinical implicationsMahmoud Loubani
Department of Integrative Human Cardiovascular Physiology and Cardiac Surgery, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK
Cardiovasc Res 61:600-9. 2004..Ischemic preconditioning confers cardioprotection in early and delayed phases. We investigated the delayed window of pharmacological and ischemic preconditioning in human myocardium, and the involvement of mitoKATP, PKC and p38MAPK...
- Effects of ATP-sensitive potassium channel activators diazoxide and BMS-191095 on membrane potential and reactive oxygen species production in isolated piglet mitochondriaDavid W Busija
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
Brain Res Bull 66:85-90. 2005..We conclude that BMS-191095 has selective effects on mitoK(ATP) channels while diazoxide also increases ROS production probably via inhibition of SDH...
- Pharmacological preconditioning with bradykinin affords myocardial protection through NO-dependent mechanismsHiroshi Yoshida
Department of Internal Medicine, Nippon Medical School, Tama Nagayama Hospital, Tama shi, Tokyo, Japan
Int Heart J 46:877-87. 2005..BK affords myocardial protection in the early phase of pharmacological preconditioning through a pathway that includes endogenous NO, PKC, and mitochondrial K(ATP) channels...
- Ischaemic preconditioning and a mitochondrial KATP channel opener both produce cardioprotection accompanied by F1F0-ATPase inhibition in early ischaemiaAntti Ala-Rämi
Department of Medical Biochemistry and Molecular Biology, University of Oulu, P O Box 5000, 90014 Oulu, Finland
Basic Res Cardiol 98:250-8. 2003..Thus mitochondrial K(ATP) channel opening and ischaemic preconditioning must share common mechanisms of action involving mitochondrial F(1)F(0)-ATPase, although involvement of the energy state in protection could not be proved...
- Effects of mitochondrial K(ATP) modulators on cardioprotection induced by chronic high altitude hypoxia in ratsJan Neckar
Institute of Physiology, Academy of Sciences of the Czech Republic and Centre for Experimental Cardiovascular Research, Videnska 1083, 142 20 Prague 4, Czech Republic
Cardiovasc Res 55:567-75. 2002..Our aim was to examine the role of mitochondrial ATP-sensitive potassium channels (K(ATP)) in this form of protection...
- Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxideY Wang
Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267-0529, USA
J Mol Cell Cardiol 33:2037-46. 2001..NO which is generated upon ischemic stress triggers the opening of mitoK(ATP)channel as an end effector of cardioprotection during late PC...
- Characteristics and superoxide-induced activation of reconstituted myocardial mitochondrial ATP-sensitive potassium channelsD X Zhang
Department of Pharmacology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Circ Res 89:1177-83. 2001..activates these channels. The effect of O(2-.) may be associated with its direct action on the sulfhydryl groups of the channel protein...
- Anesthesia's effects on plasma glucose and insulin and cardiac hexokinase at similar hemodynamics and without major surgical stress in fed ratsCoert J Zuurbier
Department of Anaesthesiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Anesth Analg 106:135-42, table of contents. 2008..In the present study, we examined how different anesthetics per se affect these variables of glucose metabolism, i.e., under similar hemodynamic conditions and in the absence of major surgical stress...
- Opening of mitochondrial K(ATP) channels attenuates the ouabain-induced calcium overload in mitochondriaH Ishida
Department of Physiology, Tokai University School of Medicine, Isehara, Japan
Circ Res 89:856-8. 2001..These results indicate that opening of mitoK(ATP) channels prevents a mitochondrial Ca(2+) overload in association with DeltaPsi(m) depolarization and thereby protects myocardium against ischemic damage...
- Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cellsM Akao
Institute of Molecular Cardiobiology, The Johns Hopkins University, Baltimore, MD, USA
Circ Res 88:1267-75. 2001..Our findings identify a novel mitochondrial pathway that is protective against apoptosis. The results also pinpoint mitoK(ATP) channels as logical therapeutic targets in diseases of enhanced apoptosis and oxidative stress...
- Hyperoxia confers myocardial protection in mechanically ventilated rats through the generation of free radicals and opening of mitochondrial ATP-sensitive potassium channelsGiuseppe Colantuono
Department of Emergency and Transplants, Section of Anaesthesia and Critical Care, University of Bari, Bari, Italy
Clin Exp Pharmacol Physiol 35:64-71. 2008..4. Hyperoxic mechanical ventilation, prior to ischaemia, reduces myocardial reperfusion injury. This is likely to occur through the induction of oxidative stress, which leads to myocyte mitoKATP channel opening...
- Na+/H+ exchanger inhibitor cariporide attenuates the mitochondrial Ca2+ overload and PTP openingTakako Toda
Department of Pediatrics, Yamanashi University School of Medicine, Yamanashi, Japan
Am J Physiol Heart Circ Physiol 293:H3517-23. 2007..05). Our data indicate that cariporide attenuates [Ca(2+)](m) overload and MPT. Thus these effects might potentially contribute to the mechanisms of cardioprotection afforded by NHE inhibitors...
- Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activationJonathan P Brennan
Cardiac Physiology Cardiovascular Division, The Rayne Institute, St Thomas Hospital, King s College London, SE1 7EH, UK
Cardiovasc Res 72:313-21. 2006....
- Sevoflurane protects stunned myocardium through activation of mitochondrial ATP-sensitive potassium channelsT Hara
Department of Anesthesiology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
Anesth Analg 92:1139-45. 2001..IMPLICATIONS: Sevoflurane exerts a cardioprotective effect that is mediated via activation of adenosine triphosphate-sensitive potassium channels in ischemic canine hearts...
- Effects of postconditioning of adenosine and acetylcholine on the ischemic isolated rat ventricular myocytesJun Lu
Department of Pharmacology, School of Medicine, Xi an Jiaotong University, Xi an, 710061, PR China, and Research Centre, Sainte Justine Hospital, Montreal, Canada
Eur J Pharmacol 549:133-9. 2006..Adenosine and acetylcholine receptor antagonists and mitoKATP inhibitor were used to analyze pathways underlying the effects on postconditioning...
- Morphine mimics preconditioning via free radical signals and mitochondrial K(ATP) channels in myocytesB C McPherson
Department of Anesthesia and Critical Care, The University of Chicago, Chicago, IL 60637, USA
Circulation 103:290-5. 2001..The resultant increase of intracellular free radical signals may be an important component of the signaling pathways by which morphine mimics preconditioning in cardiomyocytes...
- Myocardial preconditioning against ischemia-reperfusion injury is abolished in Zucker obese rats with insulin resistancePrasad V G Katakam
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Hanes 1050, Medical Center Blvd, Winston Salem, NC 27157, USA
Am J Physiol Regul Integr Comp Physiol 292:R920-6. 2007..Thus obesity accompanied by IR is associated with the inability to precondition against ischemic cardiac injury, which is mediated by enhanced mitochondrial oxidative stress and impaired activation of mitochondrial K(ATP)...
- MitoK(ATP)-dependent changes in mitochondrial volume and in complex II activity during ischemic and pharmacological preconditioning of Langendorff-perfused rat heartPhilippe Pasdois
INSERM U441, Universite Victor Segalen Bordeaux 2, Bordeaux, France
J Bioenerg Biomembr 38:101-12. 2006..It is concluded that opening the mitoK(ATP) channel mediates the preservation of mitochondrial structure-function via a mitochondrial matrix shrinkage and a reversible inactivation of complex II during prolonged ischemic insult...
- Diazoxide-induced respiratory inhibition - a putative mitochondrial K(ATP) channel independent mechanism of pharmacological preconditioningJan Minners
Hatter Institute for Cardiology Research, MRC Inter University Cape Heart Group, University of Cape Town Medical School, Cape Town, South Africa
Mol Cell Biochem 294:11-8. 2007..Collectively these data support the hypothesis that diazoxide-mediated cytoprotection is independent of the conductance of the mK(ATP) channel and rather implicate mitochondrial respiratory inhibition-triggered ROS signaling...
- Anesthetic effects on mitochondrial ATP-sensitive K channelS Kohro
Department of Anesthesiology Research, Medical College of Wisconsin, Milwaukee 53226, USA
Anesthesiology 95:1435-340. 2001..Cardioprotective effects of intravenous anesthetics may not be dependent on flavoprotein oxidation, but the administration of propofol or pentobarbital may potentially inhibit the cardioprotective effect of inhalational anesthetics...
- Potassium channel openers protect cardiac mitochondria by attenuating oxidant stress at reoxygenationCevher Ozcan
Department of Medicine, Molecular Pharmacology, and Experimental Therapeutics, Mayo Clinic, Mayo Foundation, Rochester, Minnesota 55905, USA
Am J Physiol Heart Circ Physiol 282:H531-9. 2002..Thus the cardioprotecive mechanism of K(+) channel openers includes direct attenuation of mitochondrial oxidant stress at reoxygenation...
- Exercise induces early and late myocardial preconditioning in dogsRaúl Domenech
Department of Pathophysiology, Biomedical Sciences Institute, Faculty of Medicine, University of Chile, Casilla 16038, Santiago 9, Chile
Cardiovasc Res 55:561-6. 2002..We tested the hypothesis that exercise induces myocardial preconditioning in dogs...
- Classic ischemic but not pharmacologic preconditioning is abrogated following genetic ablation of the TNFalpha geneRobert M Smith
Hatter Institute for Cardiology Research, MRC Inter University Cape Heart Group, University of Cape Town Medical School, Observatory 7925, South Africa
Cardiovasc Res 55:553-60. 2002..Moreover, whether TNFalpha is required to induce the ischemic preconditioning phenotype has not been determined...
- Acetylcholine leads to free radical production dependent on K(ATP) channels, G(i) proteins, phosphatidylinositol 3-kinase and tyrosine kinaseOlaf Oldenburg
Department of Physiology, MSB 3024, College of Medicine, University of South Alabama, Mobile 36688, USA
Cardiovasc Res 55:544-52. 2002..The aim of this study was to test whether ACh-induced ROS production could be seen in a vascular smooth muscle cell line, and, if so, to investigate the underlying signaling pathway...
- Opening of mitochondrial K(ATP) channel occurs downstream of PKC-epsilon activation in the mechanism of preconditioningYoshito Ohnuma
Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo 060 8543, Japan
Am J Physiol Heart Circ Physiol 283:H440-7. 2002..Together with the results of earlier studies showing mitochondrial K(ATP) opening by PKC, the present results suggest that mitochondrial K(ATP)-mediated cardioprotection occurs subsequent to PKC-epsilon activation by PC...
- Opening mitoKATP increases superoxide generation from complex I of the electron transport chainAnastasia Andrukhiv
Dept of Biology, Portland State Univ, PO Box 751, Portland, OR 97207, USA
Am J Physiol Heart Circ Physiol 291:H2067-74. 2006..Myxothiazol stimulated mitoK(ATP)-dependent ROS production, whereas rotenone had no effect. This indicates that the superoxide originates in complex I (NADH:ubiquinone oxidoreductase) of the electron transport chain...
- Mitochondrial ATP-sensitive K+ channels influence force development and anoxic contractility in a flatfish, yellowtail flounder Limanda ferruginea, but not Atlantic cod Gadus morhua heartTyson J MacCormack
Ocean Sciences Centre, Memorial University of Newfoundland, St John s, Newfoundland, Canada AlC 5S7
J Exp Biol 205:1411-8. 2002..Results indicate that K(ATP) channels can modulate contractility in yellowtail flounder heart and are potentially important in cardiac hypoxia survival in this species...
- The role of mitochondrial and sarcolemmal K(ATP) channels in canine ethanol-induced preconditioning in vivoPaul S Pagel
Department of Anesthesiology, Medical College of Wisconsin and Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226, USA
Anesth Analg 94:841-8, table of contents. 2002..The results indicate that mitochondrial and sarcolemmal K(ATP) channels mediate ethanol-induced preconditioning in dogs independent of alterations in systemic hemodynamics or coronary collateral blood flow...
- Protection of cardiac mitochondria by diazoxide and protein kinase C: implications for ischemic preconditioningPaavo Korge
University of California Cardiovascular Research Laboratory and Department of Medicine Cardiology, University of California School of Medicine, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 99:3312-7. 2002....
- Auxotrophy for uridine increases the sensitivity of Aspergillus niger to weak-acid preservativesPetter Melin
School of Biology, University of Nottingham, University Park, Nottingham, UK
Microbiology 154:1251-7. 2008..Several other auxotrophic strains of A. niger were screened for sensitivity to acetic, sorbic and decanoic acids. Strains auxotrophic for either adenine or uridine were found to have enhanced sensitivity but, in contrast, ..
- Proposal of Pseudorhodobacter ferrugineus gen nov, comb nov, for a non-photosynthetic marine bacterium, Agrobacterium ferrugineum, related to the genus RhodobacterYoshihito Uchino
Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
J Gen Appl Microbiol 48:309-19. 2002..ferrugineus is 1%) and their major hydroxy fatty acid compositions are 3-hydroxy decanoic acids (3-OH 10:0) and 3-hydroxy tetradecanoic acids (3-OH 14:1). However, A...
- Identification of two late acyltransferase genes responsible for lipid A biosynthesis in Moraxella catarrhalisSong Gao
Vaccine Research Section, National Institute on Deafness and Other Communication Disorders, Rockville, MD 20850, USA
FEBS J 275:5201-14. 2008..Structural analysis of lipid A from the parental strain and derived mutants showed that O35ElpxX lacked two decanoic acids (C10:0), whereas O35ElpxL lacked one dodecanoic (lauric) acid (C12:0), suggesting that lpxX encoded decanoyl ..
- Loss of ripening capacity of pawpaw fruit with extended cold storageFederica Galli
Department of Horticulture, University of Kentucky, Lexington, Kentucky 40546 0091, USA
J Agric Food Chem 56:10683-8. 2008..esters but increased levels of such off-flavor compounds as ethyl acetate, ethyl propionate, and hexanoic and decanoic acids. Alcohol acyltransferase (AAT) activity declined in cold-stored fruit but was not correlated with either total ..
- Study of the toxic effect of short- and medium-chain monocarboxylic acids on the growth of Saccharomyces cerevisiae using the CO2-auxo-accelerostat fermentation systemKaja Kasemets
National Institute of Chemical Physics and Biophysics, Laboratory of Molecular Genetics, Akadeemia tee 23, 12618 Tallinn, Estonia
Int J Food Microbiol 111:206-15. 2006The effect of aliphatic monocarboxylic acids (formic, acetic, propionic, valeric, octanoic and decanoic acids) on the growth and metabolic activity of Saccharomyces cerevisiae S288C was studied, using continuous cultivation method - CO(2)-..
- Analysis of perfluorinated carboxylic acids in soils II: optimization of chromatography and extractionJohn W Washington
United States Environmental Protection Agency, National Exposure Research Laboratory, 960 College Station Road, Athens, GA 30605, USA
J Chromatogr A 1181:21-32. 2008..in all three of our test soils, endogenous concentrations of all of our PFCA analytes, C(6) through C(10)-the lowest concentrations being roughly 30 pg/g of dry soil for perfluorinated hexanoic and decanoic acids in an agricultural soil.
- Lipid content and fatty acid composition in lemon waxMario Vincenzo Russo
Facoltà di Agraria DISTAAM, Università del Molise Via De Sanctis, 86100 Campobasso CB, Italy
Ann Chim 92:469-76. 2002..fractions the main fatty acids were hexadecanoic acid in all the fractions, cis-cis-9,12-octadecadienoic and decanoic acids in triglyceride (TG) fraction, dodecanoic and cis-9-octadecenoic acids in diglyceride (DG) fraction and ..
- Nitrogen addition influences formation of aroma compounds, volatile acidity and ethanol in nitrogen deficient media fermented by Saccharomyces cerevisiae wine strainsCatarina Barbosa
Institute for Biotechnology and Bioengineering, Centre of Genetics and Biotechnology, IBB CGB UTAD, Universidade de Tras os Montes e Alto Douro, Vila Real, Portugal
J Biosci Bioeng 108:99-104. 2009..The strain EC1118 produced significantly less medium chain fatty acids, hexanoic, octanoic and decanoic acids and their respective esters after nitrogen addition...
- Effects of perfluoro fatty acids on peroxisome proliferation and mitochondrial size in mouse liver: dose and time factors and effect of chain lengthH Permadi
Unit for Biochemical Toxicology, Department of Biochemistry, Wallenberg Laboratory, Stockholm University, S 106 91, Stockholm, Sweden
Xenobiotica 23:761-70. 2010..e. perfluoroacetic, -butyric, -octanoic and -decanoic acids) at different doses (0-02 or 0-1% w/w of diet) for different periods of time (2-10 days), and effects on liver ..
- Production of hydroxy-fatty acid derivatives from waste oil by Escherichia coli cells producing fungal cytochrome P450foxyTatsuya Kitazume
Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8572, Japan
Appl Microbiol Biotechnol 79:981-8. 2008..Decanoic acid was most efficiently converted to omega-1 to omega-3 hydroxy decanoic acids in the order of omega-1>omega-2>omega-3, with a total product yield of 47%...
- Identification of aroma compounds in Parmigiano-Reggiano cheese by gas chromatography/olfactometryM Qian
Department of Food Science and Nutrition, University of Minnesota, St Paul 55108, USA
J Dairy Sci 85:1362-9. 2002..Butanoic, hexanoic, octanoic, and decanoic acids are the major free fatty acids contributing to cheesy, lipolyzed aroma...
- Na+, K+ ATPase activity is markedly reduced by cis-4-decenoic acid in synaptic plasma membranes from cerebral cortex of ratsD R de Assis
Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, UFRGS, Porto Alegre, RS, Brazil
Exp Neurol 197:143-9. 2006We have previously demonstrated that octanoic (OA) and decanoic acids (DA) inhibit Na+, K+ ATPase activity in synaptic plasma membranes from rat brain...
- Preparation and characterization of biodegradable electrospun polyanhydride nano/microfibersQiuxiang Su
School of Materials Science and Engineering, Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, PR China
J Nanosci Nanotechnol 10:6369-75. 2010..Therefore, the electrospun polyanhydride nano/microfibers exhibited strong potential as drug delivery vehicle and tissue engineering scaffold...
- Interaction of insulin with a triblock copolymer of PEG-(fumaric-sebacic acids)-PEG: thermodynamic and spectroscopic studiesPouneh S Pourhosseini
Institute of Biochemistry and Biophysics, University of Tehran, PO Box 13145 1384, Tehran, Iran
Biochim Biophys Acta 1774:1274-80. 2007..Altogether, these observations indicate that (PEG-co-P(FA/SC)-co-PEG) triblock copolymer has similar effect(s) on both proteins...
- Structural and morphological changes of monolayers of a block copolymer with dendron and perfluoroalkyl side chains by mixing a perfluorooctadecanoic acidKoji Mitamura
Research Center for Materials Science, Nagoya University, Chikusa, Nagoya 464 8602, Japan
J Nanosci Nanotechnol 6:36-42. 2006..Especially, the amphiphilicity of perfluorinated surfactant plays a role to the ordered array of the block copolymers...
- Aerosol-derived airway morphometry (ADAM) in patients with lung emphysema diagnosed by computed tomography--reproducibility, diagnostic information and modellingB Lehnigk
Institute and Outpatient Clinic for Occupational and Environmental Medicine, Ludwig Maximilians University Munich, Ziemssenstrasse 1, 80336 Munich, Germany
Eur J Med Res 12:74-83. 2007..Average values and slopes of the EAD curve, as well as a power function for data fitting, were sensitive in the detection of type and severity of emphysema. In contrast, application of a lung model did not improve the results...
- Evolving lipid vesicles in prebiotic hydrothermal environmentsRyo Furuuchi
Department of Bioengineering, Nagaoka University of Technology, Nagaoka, 940 2188, Japan
Orig Life Evol Biosph 35:333-43. 2005..Phospholipid vesicles were destabilized by higher temperatures, and thus were found to be better suited to enhance synthetic reactions at lower temperatures...
- Additive protective effects of late and early ischaemic preconditioning are mediated by the opening of KATP channels in vivoJ Müllenheim
Klinik fur Anaesthesiologie, Heinrich Heine Universitat, Postfach 10 10 07, 40001 Dusseldorf, Germany
Pflugers Arch 442:178-87. 2001..001 versus LPC + EPC). We conclude that the combination of ischaemic LPC and EPC induces additive cardioprotection. KATP channel opening mediates the cardioprotective effects of ischaemic LPC and LPC + EPC...
- Identification of allyl esters in garlic cheeseKlaus Herbrand
Symrise GmbH and Co KG, Flavor and Nutrition, Mühlenfeldstrasse 1, 37603 Holzminden, Germany
J Agric Food Chem 55:7874-8. 2007..The identification of the allyl esters of acetic, butyric, hexanoic, heptanoic, octanoic, and decanoic acids is based on the correlation of their mass spectrometric data and chromatographic retention time data obtained ..
- Decomposition of perfluorocarboxylic acids (PFCAs) by heterogeneous photocatalysis in acidic aqueous mediumSri Chandana Panchangam
Graduate Institute of Environmental Engineering, National Taiwan University, Taipei, Taiwan, ROC
Chemosphere 77:242-8. 2009..The oxygen present in the medium served both as an oxidant and an electron acceptor. The mechanistic details of PFCA decomposition and their corresponding mineralization are elaborated...
- Nucleobases bind to and stabilize aggregates of a prebiotic amphiphile, providing a viable mechanism for the emergence of protocellsRoy A Black
Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 110:13272-6. 2013..These mutually reinforcing mechanisms might have driven the emergence of protocells. ..
- Beta-oxidation of 5-hydroxydecanoate, a putative blocker of mitochondrial ATP-sensitive potassium channelsPeter J Hanley
Institut fur Normale und Pathologische Physiologie, Universitat Marburg, Deutschhausstrasse 2, 35037 Marburg, Germany
J Physiol 547:387-93. 2003..Our results open the possibility that beta-oxidation of 5-HD or metabolic intermediates of 5-HD may be responsible for the inhibitory effects of 5-HD on preconditioning of the heart...
- In vitro evaluation of the release of albuterol sulfate from polymer gels: effect of fatty acids on drug transport across biological membranesMohammed Nasser Ali Chisty
Division of Pharmaceutics and Industrial Pharmacy, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA
Drug Dev Ind Pharm 28:1221-9. 2002..The results of this research suggest that ABS is a good candidate for transdermal drug delivery...
- Transport of a lipophilic ionizable permeant (capric acid) across a lipophilic membrane (silicone polymer membrane) from aqueous buffered solutions in the presence of hydroxypropyl-β-cyclodextrinRichard V Hymas
Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
J Pharm Sci 101:2340-52. 2012..The results of this study provide an approach that is useful in the mechanistic understanding of how cyclodextrins may enhance the passive absorption of highly lipophilic, low solubility drug molecules in the intestinal tract...
- A1 adenosine receptor overexpression decreases stunning from anoxia-reoxygenation: role of the mitochondrial K(ATP) channelRachael J Cerniway
Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville 22908, USA
Basic Res Cardiol 97:232-8. 2002....
- Polycyclic aromatic hydrocarbons as plausible prebiotic membrane componentsJoost Groen
Leiden Institute of Chemistry, Leiden University, 2333 CC Leiden, The Netherlands
Orig Life Evol Biosph 42:295-306. 2012..These data represent the first indication of a cholesterol-like stabilizing effect of oxidized PAH derivatives in a simulated prebiotic membrane...
- Acute and chronic cardioprotection by the enkephalin analogue, Eribis peptide 94, is mediated via activation of nitric oxide synthase and adenosine triphosphate-regulated potassium channelsGarrett J Gross
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Pharmacology 90:110-6. 2012..Eribis peptide 94 (EP 94) is a new enkephalin derivative which potently binds to the µ- and δ-opioid receptor. In this study, we determined the effects of EP 94 and potential mechanism(s) involved in cardioprotection of the rat heart...
- Late preconditioning in rat retina: involvement of adenosine and ATP-sensitive K(+) channelK Sakamoto
Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 9 1 Shirokane 5 chome, Tokyo 108 8641, Minato ku, Japan
Eur J Pharmacol 418:89-93. 2001..Therefore, stimulation of adenosine receptors and opening of ATP-sensitive K(+) channels might be involved in the mechanism of histological protection by late preconditioning in the retina...
- Intraneoplastic polymer-based delivery of cyclophosphamide for intratumoral bioconversion by a replicating oncolytic viral vectorT Ichikawa
Molecular Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Cancer Res 61:864-8. 2001....
- [Inhibition of Candida mycelia growth by a medium chain fatty acids, capric acid in vitro and its therapeutic efficacy in murine oral candidiasis]Miki Takahashi
Teikyo University Institute of Medical Mycology, Japan
Med Mycol J 53:255-61. 2012..These results suggest that all four fatty acids, and especially capric acid, have potential as substances supporting anti-Candida treatment...
- Direct preconditioning of cardiac myocytes via opioid receptors and KATP channelsB T Liang
Department of Medicine, Cardiovascular Division, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Circ Res 84:1396-400. 1999..These results provide direct evidence that the preconditioning-like effect of morphine in the intact heart can be exerted at the level of cardiac myocytes and is most likely the result of mitochondrial KATP channel activation...
- Percolation analysis in electrical conductivity of Madin-Darby canine kidney and Caco-2 cells by permeation-enhancing agentsMakiko Washiyama
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University, 3 3165 Higashitamagawagakuen, Machida, Tokyo 194 8543, Japan
Biol Pharm Bull 36:384-9. 2013..The findings provide fundamental knowledge, not only on controlled drug delivery, but also on bio-nanotechnologies including the fabrication of biological devices...
- Molecular dynamics simulations of barley and maize lipid transfer proteins show different ligand binding preferences in agreement with experimental dataLorna J Smith
Department of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, South Parks Road, Oxford OX1 3QR, United Kingdom
Biochemistry 52:5029-38. 2013....
- Toxicant-induced alterations in two-dimensional electrophoretic patterns of hepatic and renal stress proteinsF A Witzmann
Molecular Anatomy Laboratory, Indiana University Purdue University, Columbus, USA
Electrophoresis 17:198-202. 1996..Furthermore, because nearly all of the proteins studied were constitutively expressed at detectable levels in both liver and kidney, the 2-DE stress protein pattern may be suitable to future toxicologic screening applications...
- Modulation of slow waves by hyperpolarization with potassium channel openers in antral smooth muscle of the guinea-pig stomachYoshihiko Kito
Department of Physiology, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
J Physiol 548:175-89. 2003..The hyperpolarization shifted the threshold potential for generation of the 2nd component of slow waves to negative levels, presumably due to modulation of mitochondrial functions...
- Impact of the per-operatory application of GLIADEL wafers (BCNU, carmustine) in combination with temozolomide and radiotherapy in patients with glioblastoma multiforme: efficacy and toxicityPetra Miglierini
Department of Radiotherapy, Institute of Oncology and Haematology, University Hospital Morvan, 2 avenue Foch, Brest, France
Clin Neurol Neurosurg 114:1222-5. 2012..Only a few studies have investigated this kind of treatment regimen and the impact in terms of survival and toxicity of the combination of Gliadel with TMZ and radiotherapy...
- Induction of hepatic peroxisome proliferation by 8-2 telomer alcohol feeding in mice: formation of perfluorooctanoic acid in the liverNaomi Kudo
Faculty of Pharmaceutical Sciences, Josai University, Keyakidai 1 1, Sakado, Saitama 350 0295, Japan
Toxicol Sci 86:231-8. 2005..The present study provided evidence that 8-2 telomer alcohol is converted into PFOA in vivo and that the PFOA formed produces biological effects in the liver of mice...
- CATECHOLS AND ADENOSINE IN MYOCARDIAL PRECONDITIONINGMichael Cohen; Fiscal Year: 2006..Finally, I will see if NECA's salvage of myocardium at reperfusion translates into rapid functional benefits. It is hoped that the potential of this new pharmacologic approach can be defined. ..
- Effect of Drugs on Myocardial HypoxiaGarrett Gross; Fiscal Year: 2009..Information gained from these studies will hopefully lead to new therapies to treat patients with ischemic heart disease. ..
- BIOADHESIVE MICROSPHERESEdith Mathiowitz; Fiscal Year: 2001..The end goal is to move these novel drug delivery systems from research to clinical applications for treatment of diseases. ..
- CHRONIC HYPOXIA AND RESISTANCE TO MYOCARDIAL ISCHEMIAJohn E Baker; Fiscal Year: 2010..The results of these studies are expected to have an impact on our understanding of the biology of Tpo in heart and may lead to the development of new therapeutics for the treatment of myocardial infarction. ..
- BIOADHESIVE MICROSPHERESEdith Mathiowitz; Fiscal Year: 2002..The end goal is to move these novel drug delivery systems from research to clinical applications for treatment of diseases. ..
- GENETICS AND INTERMITTENT MYOCARDIAL HYPOXIAJohn Baker; Fiscal Year: 2003....
- NABTC Member Intitution Grant (UCSF Project Leader)Susan Chang; Fiscal Year: 2008..The overall goal of this program is to more effectively treat patients with primary brain tumors, especially malignant glioma, with the purpose of increasing the duration and quality of survival. ..
- Phase II Study of 44Gy from 131I-81C6 for CNS TumorsDavid Reardon; Fiscal Year: 2004..To further define the toxicity of this approach and Specific Aim 3.To determine the impact of this therapy on quality of life. ..
- Radiation injury to the heartJohn E Baker; Fiscal Year: 2010..1 ..
- IMPAIRED CORONARY ARTERY FUNCTION IN INSULIN RESISTANCEDavid Busija; Fiscal Year: 2003..Findings from this project may provide important information that can be used in future studies to design treatments to prevent or abort the cardiovascular complications of insulin resistance. ..
- CELLULAR AND MOLECULAR TARGETING OF TMJ DESTRUCTIONDAVID TIPTON; Fiscal Year: 2002..It is hoped that completion of these three aims will provide a detailed knowledge of the biological basis of TMJ destruction via synovial fibroblasts and MMP pathway. ..
- VASCULAR RESPONSES DURING CORTICAL SPREADING DEPRESSIONDavid Busija; Fiscal Year: 2001....
- Cerebrovascular Dysfunction in Insulin ResistanceDavid Busija; Fiscal Year: 2004..We believe that our studies will result in new and important findings that will lead to improved therapies to reduce morbidity and mortality in IR individuals. ..
- Role of inositol trisphosphate in preconditioningKarin Przyklenk; Fiscal Year: 2004....