Genomes and Genes
Summary: Usually high-molecular-weight, straight-chain primary alcohols, but can also range from as few as 4 carbons, derived from natural fats and oils, including lauryl, stearyl, oleyl, and linoleyl alcohols. They are used in pharmaceuticals, cosmetics, detergents, plastics, and lube oils and in textile manufacture. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Publications233 found, 100 shown here
- A pheromone-binding protein mediates the bombykol-induced activation of a pheromone receptor in vitroEwald Grosse-Wilde
Institute of Physiology 230, University of Hohenheim, Garbenstrasse 30, 70599 Stuttgart, Germany
Chem Senses 31:547-55. 2006..This study provides evidence that both distinct pheromone receptors and PBPs play an important role in insect pheromone recognition...
- Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substancesY Surh
Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak gu, Seoul, South Korea
Mutat Res 428:305-27. 1999..In addition, these compounds have ability to suppress proliferation of human cancer cells via induction of apoptosis...
- Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjectsSuzanna M Zick
Deoartment of Family Medicine, University of Michigan Medical School, Ann Arbor, MI 48104, USA
Cancer Epidemiol Biomarkers Prev 17:1930-6. 2008..We conducted a clinical trial with 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol, examining the pharmacokinetics and tolerability of these analytes and their conjugate metabolites...
- Update on the chemopreventive effects of ginger and its phytochemicalsManjeshwar Shrinath Baliga
Research and Development, Father Muller Medical College, Father Muller Hospital Road, Kankanady, Mangalore, 575002, Karnataka, India
Crit Rev Food Sci Nutr 51:499-523. 2011..The above-mentioned mechanisms of ginger seem to be promising for cancer prevention; however, further clinical studies are warranted to assess the efficacy and safety of ginger...
- Effect of 6-gingerol on pro-inflammatory cytokine production and costimulatory molecule expression in murine peritoneal macrophagesSudipta Tripathi
Department of Surgery, SUNY Upstate Medical University, Syracuse, New York 13210, USA
J Surg Res 138:209-13. 2007....
- Three Arabidopsis fatty acyl-coenzyme A reductases, FAR1, FAR4, and FAR5, generate primary fatty alcohols associated with suberin depositionFrederic Domergue
Laboratoire de Biogenese Membranaire, Universite Victor Segalen Bordeaux 2, CNRS, UMR 5200, 33076 Bordeaux Cedex, France
Plant Physiol 153:1539-54. 2010..consisting of phenolics, glycerol, and a variety of fatty acid derivatives, including C18:0-C22:0 primary fatty alcohols. An eight-member gene family encoding alcohol-forming fatty acyl-coenzyme A reductases (FARs) has been ..
- Synergistic cytotoxicity between tamoxifen and the plant toxin persin in human breast cancer cells is dependent on Bim expression and mediated by modulation of ceramide metabolismCaroline G Roberts
Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
Mol Cancer Ther 6:2777-85. 2007....
- Dietary ginger constituents, galanals A and B, are potent apoptosis inducers in Human T lymphoma Jurkat cellsNoriyuki Miyoshi
Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
Cancer Lett 199:113-9. 2003..In conclusion, the results from this study provide biological evidence that ginger-specific constituents other than curcuminoids are potential anticancer agents...
- A prokaryotic acyl-CoA reductase performing reduction of fatty acyl-CoA to fatty alcoholPer Hofvander
Department of Plant Breeding and Biotechnology, Swedish University of Agricultural Sciences, Alnarp, Sweden
FEBS Lett 585:3538-43. 2011..The Marinobacter fatty acyl reductase studied has a wide substrate range in comparison to what can be found among enzymes so far studied in eukaryotes...
- -Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skinSue Ok Kim
College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
Oncogene 24:2558-67. 2005..Taken together, our data suggest that -gingerol inhibits TPA-induced COX-2 expression in mouse skin in vivo by blocking the p38 MAP kinase-NF-kappaB signaling pathway...
- Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol) in elderly hypercholesterolemic patientsGiuseppe Marazzi
Department of Medical Sciences, IRCCS San Raffaele, Rome, Italy
Adv Ther 28:1105-13. 2011..The purpose of this study was to examine the efficacy, safety, and tolerability of a nutraceutical-based protocol in elderly hypercholesterolemic patients previously intolerant to statins...
- Policosanol is ineffective in the treatment of hypercholesterolemia: a randomized controlled trialMichael F Dulin
Carolinas Medical Center Department of Family Medicine, Charlotte, NC, USA
Am J Clin Nutr 84:1543-8. 2006..Recent studies have challenged these findings, but there have been no trials conducted in North America that have examined the ability of sugar cane-derived policosanol to lower cholesterol...
- -Gingerol attenuates β-amyloid-induced oxidative cell death via fortifying cellular antioxidant defense systemChan Lee
College of Oriental Medicine, Daegu Haany University, Daegu 706 828, South Korea
Food Chem Toxicol 49:1261-9. 2011..These results suggest that -gingerol exhibits preventive and/or therapeutic potential for the management of AD via augmentation of antioxidant capacity...
- In vitro and in vivo modulation of testosterone mediated alterations in apoptosis related proteins by -gingerolYogeshwer Shukla
Proteomics Laboratory, Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India
Mol Nutr Food Res 51:1492-502. 2007..Thus, -gingerol shows its protective effects in both in vivo and in vitro prostate cancer models by modulation of proteins involved in apoptosis pathway...
- Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cellsSeong Ho Lee
The Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996 4542, USA
Mol Carcinog 47:197-208. 2008..Multiple mechanisms appear to be involved in 6-gingerol action, including protein degradation as well as beta-catenin, PKCepsilon, and GSK-3beta pathways...
- -Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivoEok Cheon Kim
Department of Biochemistry, College of Natural Sciences, Yonsei University, Seoul, Republic of Korea
Biochem Biophys Res Commun 335:300-8. 2005..Taken together, these results demonstrate that -gingerol inhibits angiogenesis and may be useful in the treatment of tumors and other angiogenesis-dependent diseases...
- Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerolsShengmin Sang
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, 164 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
J Agric Food Chem 57:10645-50. 2009..In addition, we found that -shogaol had much stronger inhibitory effects on arachidonic acid release and nitric oxide (NO) synthesis than -gingerol...
- -Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cellsYon Jung Park
Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemoon Gu, Seoul 120 752, Korea
Yonsei Med J 47:688-97. 2006....
- In vitro synthesis of curcuminoids by type III polyketide synthase from Oryza sativaYohei Katsuyama
Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
J Biol Chem 282:37702-9. 2007....
- Plaunotol induces apoptosis of gastric cancer cellsJun Yamada
Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Planta Med 73:1068-73. 2007..Plaunotol should be a promising new antitumor agent, and since it is already available for clinical use in Japan, its anticancer properties should be confirmed in clinical trials...
- Photosynthesis driven conversion of carbon dioxide to fatty alcohols and hydrocarbons in cyanobacteriaXiaoming Tan
Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, China
Metab Eng 13:169-76. 2011..Here we describe the biosynthesis of fatty alcohols in a genetically engineered cyanobacterial system through heterologously expressing fatty acyl-CoA reductase ..
- Ginger ingredients reduce viability of gastric cancer cells via distinct mechanismsKazuhiro Ishiguro
Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
Biochem Biophys Res Commun 362:218-23. 2007....
- Effects of a policosanol supplement on serum lipid concentrations in hypercholesterolaemic and heterozygous familial hypercholesterolaemic subjectsA Greyling
School of Physiology, Nutrition and Consumer Sciences, North West University Potchefstroom Campus, South Africa
Br J Nutr 95:968-75. 2006..An intake of 20 mg/d policosanol for 12 weeks had no significant effect on serum lipid levels in hypercholesterolaemic and heterozygous familial hypercholesterolaemic patients when compared with placebo intake...
- Genetic variation of Croton stellatopilosus Ohba based on non-coding DNA sequences of ITS, trnK and trnL-F regionsPrasob Orn Rinthong
Faculty of Pharmacy, Mahasarakham University, Maha Sarakham, Thailand
J Nat Med 65:641-5. 2011..209-0.492, 0.319-0.896 and 0.442-1.000% (w/w) dry weight, respectively. The results indicated that there is a correlation between the plaunotol contents and non-coding DNA sequences of ITS, trnK and trnL-F regions of C. stellatopilosus...
- Comparative lipid-lowering effects of policosanol and atorvastatin: a randomized, parallel, double-blind, placebo-controlled trialLuigi X Cubeddu
Division of Cardiology and Department of Internal Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
Am Heart J 152:982.e1-5. 2006..This trial was designed to rigorously establish the lipid-lowering efficacy of policosanol as monotherapy and its potential additive and possibly synergistic effects when added to statin therapy...
- Effects of policosanol and ticlopidine in patients with intermittent claudication: a double-blinded pilot comparative studyGladys Castaño
Medical Surgical Research Center, Havana City, Cuba
Angiology 55:361-71. 2004..This study is, however, just a pilot comparison, so that further studies in larger sample sizes are needed for definitive conclusions of the comparative effects of both drugs on patients with IC...
- [Non-alcoholic hepatic steatosis: the role of policosanols in associated hyperlipidemia]D Musto
Unità Operativa Complessa di Gastroenterologia e Endoscopia Digestiva, Seconda Universita degli Studi di Napoli, Napoli, Italia
Minerva Gastroenterol Dietol 56:389-95. 2010..The purpose of this study was to evaluate the efficacy of policosanols in the treatment of associated hyperlipidemia in patients with non-alcoholic fatty liver disease (NAFLD)...
- (2E,6Z,10E)-7-hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetraen-1-ol (Plaunotol) increases cyclooxygenase-2 expression via nuclear factor kappaB and cyclic AMP response element in rat gastric epithelial cellsHai Ying Fu
Department of Clinical Laboratory Science, School of Allied Heath Sciences, Osaka University Graduate School, Suita City, Japan
Eur J Pharmacol 524:38-43. 2005..In conclusion, plaunotol induced COX-2 expression and increased PGE(2) production in serum-starved RGM1 cells via activation of the NF-kappaB and CRE sites of Cox-2 gene promoters...
- A novel plant toxin, persin, with in vivo activity in the mammary gland, induces Bim-dependent apoptosis in human breast cancer cellsAlison J Butt
Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, New South Vales 2010, Australia
Mol Cancer Ther 5:2300-9. 2006..Due to the unique structure of the compound, persin could represent a novel class of microtubule-targeting agent with potential specificity for breast cancers...
- Synthesis and in vitro evaluation of analogues of avocado-produced toxin (+)-(R)-persin in human breast cancer cellsDarby G Brooke
Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
Bioorg Med Chem 19:7033-43. 2011..A 4-pyridinyl derivative demonstrated activity comparable to that of the natural product, suggesting future directions for exploration of structure-activity relationships...
- Induction of apoptosis by -gingerol associated with the modulation of p53 and involvement of mitochondrial signaling pathway in B[a]P-induced mouse skin tumorigenesisNidhi Nigam
Proteomics Laboratory, Indian Institute of Toxicology Research CSIR, M G Marg, P O Box 80, Lucknow 226001, India
Cancer Chemother Pharmacol 65:687-96. 2010....
- Optimization of fatty alcohol biosynthesis pathway for selectively enhanced production of C12/14 and C16/18 fatty alcohols in engineered Escherichia coliYan Ning Zheng
Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Laoshan District, Qingdao 266101, China
Microb Cell Fact 11:65. 2012..Though bioproduction of fatty alcohols has been carried out in engineered E...
- Policosanol inhibits cholesterol synthesis in hepatoma cells by activation of AMP-kinaseDev K Singh
College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
J Pharmacol Exp Ther 318:1020-6. 2006..Because AMP-kinase is activated by phosphorylation and is well established to suppress HMG-CoA reductase activity, these results suggest that policosanol or a metabolite decreases HMG-CoA reductase activity by activating AMP-kinase...
- Production of medium chain length fatty alcohols from glucose in Escherichia coliJ Tyler Youngquist
Department of Chemical and Biological Engineering, University of Wisconsin Madison, 3629 Engineering Hall, 1415 Engineering Drive, Madison, WI 53706, United States Great Lakes Bioenergy Research Center, University of Wisconsin Madison, Madison, WI 53706, United States
Metab Eng 20:177-86. 2013..Microbial synthesis of fatty alcohols is an attractive process because it can control the distribution of chain lengths and utilize low cost ..
- Effect of plaunotol in combination with clarithromycin or amoxicillin on Helicobacter pylori in vitro and in vivoTetsufumi Koga
Biological Research Laboratories, Sankyo Co, Ltd, 2 58 Hiromachi 1 chome, Shinagawa ku, Tokyo 140 8710, Japan
J Antimicrob Chemother 50:133-6. 2002..These results suggest that plaunotol may have a useful role in combination with anti-H. pylori drugs in the treatment of H. pylori-associated diseases...
- Preventive effect of D-002, a mixture of long-chain alcohols from beeswax, on the liver damage induced with CCl4 in ratsSarahi Mendoza
Centre of Natural Products, National Centre for Scientific Research, Havana City, Cuba
J Med Food 10:379-83. 2007..Since increased liver lipid peroxidation has been postulated as a cause of CCl4-induced liver damage in rats, the preventive effects of D-002 could be due to its antioxidant action, but such a proposal still requires further research...
- Isolation and characterization of triacontanol-regulated genes in rice (Oryza sativa L.): possible role of triacontanol as a plant growth stimulatorXinping Chen
Key Laboratory of Ministry of Education for Plant Developmental Biology, Wuhan University, Wuhan 430072, PR China
Plant Cell Physiol 43:869-76. 2002..Time-course profiles of expression of rbcS isogenes suggested the complex mechanisms involved in the regulation of photosynthesis promoted by TRIA...
- Tocopherol long chain fatty alcohols decrease the production of TNF-alpha and NO radicals by activated microglial cellsThierry Muller
Laboratoire de Chimie Organique des Substances Naturelles, Centre de Neurochimie, UMR 7123 CNRS, Universite Louis Pasteur, 67084 Strasbourg, France
Bioorg Med Chem Lett 14:6023-6. 2004The synthesis of a series of Tocopherol long chain Fatty Alcohols (TFA) and their biological activities on the modulation of microglial activation are described...
- Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cellsGennady Rosenblat
Polyol Biotech Ltd, Granot Initiative Center, D N Hefer, Israel
Arch Dermatol Res 303:239-46. 2011..The present study tested the ability of unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, to reduce UVB-induced damage and inflammation in skin...
- Long-chain fatty alcohols from pomace olive oil modulate the release of proinflammatory mediatorsAngeles Fernandez-Arche
Department of Pharmacology, University of Seville, Spain
J Nutr Biochem 20:155-62. 2009..The nonglyceride matter of this oil is a good source of interesting minor compounds, like long-chain fatty alcohols, which are present free or as part of waxes...
- Instrument dependence of electrospray ionization and tandem mass spectrometric fragmentation of the gingerolsHongliang Jiang
Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
Rapid Commun Mass Spectrom 20:3089-100. 2006....
- Modified-policosanol does not reduce plasma lipoproteins in hyperlipidemic patients when used alone or in combination with statin therapyJames M Backes
Schools of Pharmacy and Medicine, The University of Kansas Medical Center, Kansas, USA
Lipids 46:923-9. 2011..Consistent with recent clinical trial data, MP demonstrated an excellent safety profile but produced no significant effects on major lipoproteins when used as monotherapy or when given with concomitant statin therapy...
- Cancer preventive properties of ginger: a brief reviewYogeshwer Shukla
Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226 001, Uttar Pradesh, India
Food Chem Toxicol 45:683-90. 2007..A number of mechanisms that may be involved in the chemopreventive effects of ginger and its components have been reported from the laboratory studies in a wide range of experimental models...
- Gingerol content of diploid and tetraploid clones of ginger (Zingiber officinale Roscoe)Hans Wohlmuth
School of Natural and Complementary Medicine, Southern Cross University, PO Box 157, Lismore, NSW 2480, Australia
J Agric Food Chem 53:5772-8. 2005..In contrast to previous findings, this study did not find significant differences in gingerol concentrations between the tetraploid clones and their parent diploid cultivar...
- The antimycobacterial constituents of dill (Anethum graveolens)Michael Stavri
Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Square, UK
Phytother Res 19:938-41. 2005..The three known compounds exhibited antibacterial activity against a panel of rapidly growing mycobacteria with minimum inhibitory concentration (MIC) values in the range 2-128 microg/mL...
- Release studies on niosomes containing fatty alcohols as bilayer stabilizers instead of cholesterolGopi N Devaraj
University College of Pharmaceutical Sciences, Kakatiya University, Warangal, 506 009, India
J Colloid Interface Sci 251:360-5. 2002..We have substituted cholesterol with fatty alcohols in niosomes containing polyglyceryl-3-di-isostearate (PGDS) and polysorbate-80 (PS-80) to explore their ..
- Characterization of a fatty acyl-CoA reductase from Marinobacter aquaeolei VT8: a bacterial enzyme catalyzing the reduction of fatty acyl-CoA to fatty alcoholRobert M Willis
Department of Chemistry and Biochemistry, Utah State University, Logan, Utah 84322, United States
Biochemistry 50:10550-8. 2011b>Fatty alcohols are of interest as a renewable feedstock to replace petroleum compounds used as fuels, in cosmetics, and in pharmaceuticals...
- Dietary diacetylene falcarindiol induces phase 2 drug-metabolizing enzymes and blocks carbon tetrachloride-induced hepatotoxicity in mice through suppression of lipid peroxidationTomokazu Ohnuma
Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192 0392, Japan
Biol Pharm Bull 34:371-8. 2011..These results suggest that the protective effects of falcarindiol against CCl(4) toxicity might, in part, be explained by anti-lipid peroxidation activity associated with the induction of the GSTs including GSTA4...
- Skin permeation enhancement effect and skin irritation of saturated fatty alcoholsN Kanikkannan
College of Pharmacy and Pharm Science, Florida A and M University, Tallahassee 32307, USA
Int J Pharm 248:219-28. 2002..of this study was to evaluate the skin permeation enhancement effect and skin irritation of saturated fatty alcohols using melatonin as a model compound...
- Functional expression of five Arabidopsis fatty acyl-CoA reductase genes in Escherichia coliThuy T P Doan
Department of Plant Breeding and Biotechnology, Swedish University of Agricultural Sciences, P O Box 101, 23053 Alnarp, Sweden
J Plant Physiol 166:787-96. 2009..The five functional FAR enzymes yielded distinctly different compositions of fatty alcohols when expressed in E...
- Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol-lowering agents. A single-blind clinical investigationArrigo F G Cicero
G Descovich Atherosclerosis and Dysmetabolic Disease Research Center, D Campanacci Clinical Medicine and Applied Biotechnology Department, University of Bologna, Bologna, Italy
Arzneimittelforschung 57:26-30. 2007....
- Effect of policosanol on lipid levels among patients with hypercholesterolemia or combined hyperlipidemia: a randomized controlled trialHeiner K Berthold
Department of Clinical Pharmacology, Institute for Clinical Research, Center for Cardiovascular Diseases, Rotenburg an der Fulda, Germany
JAMA 295:2262-9. 2006..More than 80 placebo-controlled or comparative trials, performed mostly by a single research institute, suggest that policosanol at doses of 5 to 40 mg/d has lipoprotein-lowering effects comparable with statins...
- Molecular mechanisms underlying sex pheromone production in the silkmoth, Bombyx mori: characterization of the molecular components involved in bombykol biosynthesisShogo Matsumoto
Molecular Entomology Laboratory, RIKEN The Institute of Physical and Chemical Research, Hirosawa 2 1, Wako, Saitama 351 0198, Japan
J Insect Physiol 53:752-9. 2007..Characterization of these, and other, key molecules will facilitate our understanding of the precise mechanisms underlying lepidopteran sex pheromone production...
- Systemic administration of -gingerol, a pungent constituent of ginger, induces hypothermia in rats via an inhibitory effect on metabolic rateShiori Ueki
Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine, Yonago, Tottori 683, Japan
Eur J Pharmacol 584:87-92. 2008....
- Octacosanol in human healthJohanna C Taylor
School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom
Nutrition 19:192-5. 2003
- Effects of a nutraceutical combination (berberine, red yeast rice and policosanols) on lipid levels and endothelial function randomized, double-blind, placebo-controlled studyF Affuso
Department of Internal Medicine, Cardiovascular and Immunologic Sciences, University of Naples Federico II, Naples, Italy
Nutr Metab Cardiovasc Dis 20:656-61. 2010..We evaluated the effects of a nutraceutical combination (NC), consisting of 500 mg berberine, 200mg red yeast rice and 10mg policosanols, on cholesterol levels and endothelial function in patients with hypercholesterolemia...
- Nutritional significance and metabolism of very long chain fatty alcohols and acids from dietary waxesJames L Hargrove
Department of Foods and Nutrition, University of Georgia, Athens, Georgia 30602, USA
Exp Biol Med (Maywood) 229:215-26. 2004Very long chain fatty alcohols obtained from plant waxes and beeswax have been reported to lower plasma cholesterol in humans...
- Gqalpha-linked phospholipase Cbeta1 and phospholipase Cgamma are essential components of the pheromone biosynthesis activating neuropeptide (PBAN) signal transduction cascadeJ J Hull
Molecular Entomology Laboratory, RIKEN Advanced Science Institute, Wako, Saitama, Japan
Insect Mol Biol 19:553-66. 2010..In vivo RNA interference-mediated knockdown analyses revealed that BmPLCbeta1, BmGq1, and unexpectedly, BmPLCgamma, are part of the PBAN signal transduction cascade...
- Dual bioactivity of resveratrol fatty alcohols: differentiation of neural stem cells and modulation of neuroinflammationFrédérique Hauss
Laboratoire de Chimie Organique des Substances Naturelles, UMR 7177 CNRS, Universite Louis Pasteur, 67084 Strasbourg Cedex, France
Bioorg Med Chem Lett 17:4218-22. 2007The synthesis of resveratrol fatty alcohols (RFAs), a new class of small molecules presenting strong potential for the treatment of neurological diseases, is described...
- Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by -gingerolA M Bode
The Hormel Institute, University of Minnesota, Austin 55912, USA
Cancer Res 61:850-3. 2001..Our results provide the first evidence that both block EGF-induced cell transformation but act by different mechanisms...
- Effects of policosanols and phytosterols on lipid levels and cholesterol biosynthesis in hamstersY W Wang
School of Dietetics and Human Nutrition, McGill University, Macdonald Campus, Ste Anne de Bellevue, QC, Canada H9X 3V9
Lipids 38:165-70. 2003..Results suggest that, although phytosterols reduce T-C and HDL-C levels, policosanols have no significant favorable effect in changing lipid levels in hamsters...
- Kinetics and molecular properties of pheromone binding and releaseWalter S Leal
Maeda Duffey Laboratory, Department of Entomology, University of California, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 102:5386-91. 2005..Fluorescence studies shed light on the contributions of Trp-37 and Trp-127 emissions to the overall fluorescence...
- Inhibitory effects of feeding with carrots or (-)-falcarinol on development of azoxymethane-induced preneoplastic lesions in the rat colonMorten Kobaek-Larsen
Biomedical Laboratory, University of Southern Denmark, Winsloewparken 23, DK 5000 Odense C, Denmark
J Agric Food Chem 53:1823-7. 2005..The present study provides a new perspective on the known epidemiological associations between high intake of carrots and reduced incidence of cancers...
- Very long chain fatty acids (policosanols) and phytosterols affect plasma lipid levels and cholesterol biosynthesis in hamstersYanwen Wang
School of Dietetics and Human Nutrition, GcGill University, Ste Anne de Bellevue, Quebec, Canada
Metabolism 54:508-14. 2005..05) in animals fed VLCFA25 and VLCFA50 than those fed control or VLCFA25/LT or VLCFA25/PS. Results suggest that PSs can decrease total and non-HDL-C cholesterol, whereas VLCFA may increase HDL-C in hamsters...
- Pheromone reception in fruit flies expressing a moth's odorant receptorZainulabeuddin Syed
Department of Entomology, University of California, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 103:16538-43. 2006..We also found an endogenous receptor in one of the sensillum types on Drosophila antenna that responds to bombykol and bombykal with sensitivity comparable to the pheromone-detecting sensilla on B. mori male antennae...
- Pheromone discrimination by the pheromone-binding protein of Bombyx moriFrauke Gräter
Department of Theoretical and Computational Biophysics, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
Structure 14:1577-86. 2006..While BmorPBP might filter out other physiologically irrelevant compounds hitting the sensillar lymph, discrimination between the natural pheromone compounds must be achieved by molecular interactions with their cognate receptors...
- Suppressive effects of mioga ginger and ginger constituents on reactive oxygen and nitrogen species generation, and the expression of inducible pro-inflammatory genes in macrophagesHa Won Kim
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606 8501, Japan
Antioxid Redox Signal 7:1621-9. 2005..Taken together, these results suggest that aframodial has potent antioxidative and anti-inflammatory potentials, and may be a promising candidate in prevention and/or therapy for chronic inflammationassociated carcinogenesis...
- The metabolism of fatty alcohols in lipid nanoparticles by alcohol dehydrogenaseX Dong
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0082, USA
Drug Dev Ind Pharm 32:973-80. 2006b>Fatty alcohols are commonly used in lipid-based drug delivery systems including parenteral emulsions and solid lipid nanoparticles (NPs)...
- Lack of cholesterol-lowering efficacy of Cuban sugar cane policosanols in hypercholesterolemic personsAmira N Kassis
School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Montreal, Quebec, Canada
Am J Clin Nutr 84:1003-8. 2006..However, several animal and human trials conducted outside of Cuba that used non-Cuban mixtures have failed to reproduce the efficacy of policosanols observed in earlier studies...
- In vitro and in vivo study of octacosanol metabolismRoberto Menendez
Center of Natural Products, National Center for Scientific Research, Havana City, Cuba
Arch Med Res 36:113-9. 2005..Scarce data about the metabolism of octacosanol and the other fatty alcohols composing policosanol have been published.
- Structural and sensory characterization of compounds contributing to the bitter off-taste of carrots (Daucus carota L.) and carrot pureeAndreas Czepa
Deutsche Forschungsanstalt fur Lebensmittelchemie, Lichtenbergstrasse 4, D 85748 Garching, Germany
J Agric Food Chem 51:3865-73. 2003..04 mmol/kg, thus demonstrating that this acetylenic diol significantly contributes to the bitter taste of the carrot products investigated...
- Male gametophyte development in bread wheat (Triticum aestivum L.): molecular, cellular, and biochemical analyses of a sporophytic contribution to pollen wall ontogenyAiming Wang
Plant Biotechnology Institute, National Research Council of Canada, 110 Gymnasium Place, Saskatoon, Saskatchewan, Canada S7N 0W9
Plant J 30:613-23. 2002..the assembly of wall-impregnated sporopollenin, a phenylpropanoid-lipid polymer containing very long chain fatty alcohols (VLCFAlc), described in the literature...
- Gingerol metabolite and a synthetic analogue Capsarol inhibit macrophage NF-kappaB-mediated iNOS gene expression and enzyme activityFugen Aktan
Faculty of Pharmacy, University of Sydney, New South Wales, Australia
Planta Med 72:727-34. 2006....
- Olefin cross-metathesis as a tool in natural product degradation. The stereochemistry of (+)-falcarindiolAnokha S Ratnayake
Department of Chemistry, University of Hawaii, 2545 McCarthy Mall, Honolulu, Hawaii 96822, USA
Org Lett 4:4667-9. 2002..Degradation of (+)-falcarindiol from Tetraplasandra hawaiiensis yields a meso product as shown by chiral HPLC. Hence, (+)-falcarindiol from this source has a (3R,8S)-configuration...
- Comparison of the efficacy, safety and tolerability of original policosanol versus other mixtures of higher aliphatic primary alcohols in patients with type II hypercholesterolemiaG Castano
Medical and Surgical Research Center, National Center for Scientific Research, Havana, Cuba
Int J Clin Pharmacol Res 22:55-66. 2002..Thus, policosanol reached the efficacy criterion for LDL-C reduction in both steps, while Octa-60 failed to reach this goal. In addition, policosanol was better tolerated than Octa-60...
- Virucidal activities of medium- and long-chain fatty alcohols and lipids against respiratory syncytial virus and parainfluenza virus type 2: comparison at different pH levelsH Hilmarsson
Institute of Biology, University of Iceland, Reykjavik, Iceland
Arch Virol 152:2225-36. 2007Recent studies have shown that some lipids and fatty alcohols have microbicidal activities against a broad variety of pathogens...
- Ginger (Zingiber officinale Roscoe) and the gingerols inhibit the growth of Cag A+ strains of Helicobacter pyloriGail B Mahady
Department of Pharmacy Practice, UIC NIH Center for Botanical Dietary Supplements Research, PAHO WHO Collaborating Centre for Traditional Medicine, University of Illinois at Chicago, 833 S Wood St, MC 877, Chicago, IL 60612, USA
Anticancer Res 23:3699-702. 2003..Since Helicobacter pylori (HP) is the primary etiological agent associated with dyspepsia, peptic ulcer disease and the development of gastric and colon cancer, the anti-HP effects of ginger and its constituents were tested in vitro...
- Effects of policosanol and lovastatin on lipid profile and lipid peroxidation in patients with dyslipidemia associated with type 2 diabetes mellitusG Castano
Medical Surgical Research Center, Havana City, Cuba
Int J Clin Pharmacol Res 22:89-99. 2002..Nevertheless, since this was a pilot study, further clinical studies performed in larger sample sizes of diabetic patients are needed for definitive conclusions...
- Antibacterial activity of long-chain fatty alcohols against Staphylococcus aureusNaoko Togashi
Department of Microbiology, Showa Pharmaceutical University, Machida, 194 8543 Tokyo, Japan
Molecules 12:139-48. 2007The antibacterial activity against Staphylococcus aureus of long-chain fatty alcohols was investigated, with a focus on normal alcohols...
- Biphasic effect of falcarinol on caco-2 cell proliferation, DNA damage, and apoptosisJette F Young
Danish Institute of Agricultural Sciences, Department of Food Science, Research Centre Foulum, P O Box 50, DK 8830 Tjele, Denmark
J Agric Food Chem 55:618-23. 2007..Thus, the effects of falcarinol on CaCo-2 cells appear to be biphasic, inducing pro-proliferative and apoptotic characteristics at low and high concentrations of falcarinol, respectively...
- Policosanol modulates HMG-CoA reductase activity in cultured fibroblastsR Menendez
Laboratorio de Bioquimica, Centro de Productos Naturales, Centro Nacional de Investigación Científica, Havana, Cuba
Arch Med Res 32:8-12. 2001..Cholesterol biosynthesis is strictly controlled by 3-hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) reductase...
- Molecular switches for pheromone release from a moth pheromone-binding proteinWei Xu
Maeda Duffey Laboratory, Department of Entomology, University of California, 1 Shields Avenue, Davis, CA 95616, USA
Biochem Biophys Res Commun 372:559-64. 2008..The former leads to the formation of a new alpha-helix, which competes with pheromone for the binding pocket, whereas positive charge repulsion of the histidines opens the opposite side of the binding pocket...
- Comparison of composition and absorption of sugarcane policosanolsChristopher P F Marinangeli
School of Dietetics and Human Nutrition, McGill University, Ste Anne de Bellevue, Quebec, H9X 3V9 Canada
Br J Nutr 97:381-8. 2007..05) than hamsters receiving APC1. If the cholesterol-lowering efficacy of PC mixtures is dependent on their purity and composition, then sugarcane-derived APC products should possess similar therapeutic properties as the OPC supplement...
- Inhibitory effects of -gingerol on PMA-induced COX-2 expression and activation of NF-kappaB and p38 MAPK in mouse skinSue Ok Kim
College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
Biofactors 21:27-31. 2004..In addition, -gingerol inhibited the phoshorylation of p38 mitogen-activated protein kinase which may account for its inactivation of NF-kappaB and suppression of COX-2 expression...
- Analgesic and anti-inflammatory activities of -gingerolHaw Yaw Young
TzuHui Institute of Technology, 926 Ping Tung, Taiwan, ROC
J Ethnopharmacol 96:207-10. 2005..6]-Gingerol (50 mg/kg-100 mg/kg) also produced an inhibition of paw edema induced by carrageenin. These results suggested that -gingerol possessed analgesic and anti-inflammatory activities...
- Effects of indole fatty alcohols on the differentiation of neural stem cell derived neurospheresDjalil Coowar
Laboratoire de Chimie Organique des Substances Naturelles, UMR 7123 CNRS, Universite Louis Pasteur, 5 rue Blaise Pascal, 67084 Strasbourg, France
J Med Chem 47:6270-82. 2004..neuronal differentiation to treat neurodegenerative diseases such as Alzheimer's disease, a series of indole fatty alcohols (IFAs) were prepared...
- Sexual attraction in the silkworm moth: structure of the pheromone-binding-protein-bombykol complexB H Sandler
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853 1301, USA
Chem Biol 7:143-51. 2000..The structure of the pheromone-binding protein, its binding and recognition of bombykol, and its full role in signal transduction are not known...
- Wheat germ policosanol failed to lower plasma cholesterol in subjects with normal to mildly elevated cholesterol concentrationsYuguang Lin
Unilever Health Institute, Unilever R and D, Vlaardingen, The Netherlands
Metabolism 53:1309-14. 2004..In conclusion, WGP at 20 mg/d had no beneficial effects on blood lipid profiles. It therefore seems unlikely that the long chain (C24-34) alcohols have any cholesterol-lowering activity...
- Isolation of novel glucosides related to gingerdiol from ginger and their antioxidative activitiesY Sekiwa
Graduate School of Humanities and Sciences, Laboratory of Food Chemistry, Department of Nutrition and Food Science, Ochanomizu University, 2 1 1 Ohtsuka, Bunkyo ku, Tokyo 112 8610, Japan
J Agric Food Chem 48:373-7. 2000..Although 1 did not indicate any activity, 2 had as strong activity as the aglycon in both measurements...
- Sexual attraction in the silkworm moth. Nature of binding of bombykol in pheromone binding protein--an ab initio studyVojtech Klusák
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, and Center for Complex Molecular Systems and Biomolecules, Flemingovo nam 2, Praha 6, 166 10, Czech Republic
Chem Biol 10:331-40. 2003..All of these interactions are well defined and cannot be considered as nonspecific hydrophobic interactions, one of the major conclusions of this work...
- Topical vehicles based on natural surfactant/fatty alcohols mixed emulsifier: The influence of two polyols on the colloidal structure and in vitro/in vivo skin performanceSnezana Savic
Faculty of Pharmacy, Institute of Pharmaceutical Technology and Cosmetology, Belgrade Vojvode Stepe 450, 11221 Belgrade, Serbia
J Pharm Sci 98:2073-90. 2009..Contrary to the effect of PG, the results obtained with GL suggest that it may have a permeation-retarding rather than a permeation-enhancing effect in topical vehicles of this type...
- Insect sex-pheromone signals mediated by specific combinations of olfactory receptorsTakao Nakagawa
Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277 8562, Japan
Science 307:1638-42. 2005..The same effects were also observed for general ORs. Both odorant and pheromone signaling pathways are mediated by means of a common mechanism in insects...
- On the proof and disproof of natural product stereostructures: characterization and analysis of a twenty-eight member stereoisomer library of murisolins and their Mosher ester derivativesDennis P Curran
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Am Chem Soc 128:9943-56. 2006..The structure of murisolin was proved to be the 4R,15R,16R,19R,20R,34S isomer, whereas the assignment of 16,19-cis-murisolin as RRRSSS was changed to the RSSRRS diastereomer and murisolin A is suggested to be RSRRRS...
- Synthesis of the proposed structure of mucoxin via regio- and stereoselective tetrahydrofuran ring-forming strategiesRadha S Narayan
Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA
J Org Chem 71:1416-29. 2006..On the basis of detailed spectroscopic analysis of the synthesized molecule, we reason that the spectral discrepancies are due to stereochemical misassignment of the natural product...
- Total synthesis of the proposed structure for pyragonicinShunya Takahashi
RIKEN The Institute of Physical and Chemical Research, Wako, Saitama 351 0198, Japan
Org Lett 7:2783-6. 2005..Compound 1 had spectroscopic data consistent with that of natural pyragonicin, but a different optical rotation...
- New strategy for the construction of a monotetrahydrofuran ring in Annonaceous acetogenin based on a ruthenium ring-closing metathesis: application to the synthesis of SolaminGuillaume Prestat
CEA, CE Saclay, Service de Marquage Moleculaire et de Chimie Bioorganique, Bat 547, Departement de Biologie Joliot Curie, 91191 Gif sur Yvette, France
J Org Chem 69:5770-3. 2004..The flexibility of the strategy should be useful in preparing various natural and unnatural annonaceous acetogenins...
- Total synthesis of jimenezin via an intramolecular allylborationNina G Bandur
Fachbereich Chemie, Philipps Universitat Marburg, Hans Meerwein Strasse, 35032 Marburg, Germany
Org Lett 8:3829-31. 2006..The key steps used were a highly stereoselective intramolecular allylboration to establish the tetrahydropyran ring and an intramolecular Williamson reaction to close the tetrahydrofuran ring...
- Total synthesis of the nonadjacently linked bis-tetrahydrofuran acetogenin bullatanocin (squamostatin C)Lei Zhu
Department of Chemistry, Hunter College CUNY, 695 Park Avenue, New York, New York 10021, USA
J Org Chem 69:3154-7. 2004..The synthesis confirms the structure of the natural product, and its convergent design makes it especially attractive for analogue synthesis...
- Total synthesis of (+)-muconinTakehiko Yoshimitsu
Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo 204 8588, Japan
J Org Chem 69:1993-8. 2004..In this study, a new route was established for obtaining (+)-muconin (1) starting with (-)-muricatacin (2), a compound recently synthesized via the novel alpha-C-H hydroxyalkylation and alpha'-C-H oxidation of tetrahydrofuran...
- Synthesis of pyragonicinDaniel Strand
KTH Chemistry, Organic Chemistry, SE 100 44 Stockholm, Sweden
Org Lett 7:2779-81. 2005..A reagent controlled zinc-mediated stereoselective coupling, joining the two highly functionalized intermediates 3 and 4, then provided the core structure...
- Function of the alkyl side chains of Deltalac-acetogenins in the inhibitory effect on mitochondrial complex I (NADH-ubiquinone oxidoreductase)Naoya Ichimaru
Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
Bioorg Med Chem Lett 16:3555-8. 2006..This is probably because such properties decide the precise location of the hydrophilic bis-THF ring moiety in the enzyme embedded in the inner mitochondrial membrane...
- 9 CIS RETINOL DEHYDROGENASE--PROPERTIES AND PHYSIOLOGYWILLIAM BLANER; Fiscal Year: 2004..13-cis- and all-trans-retinol but not other retinoids or long chain fatty acids, short chain fatty acids or fatty alcohols. For the mouse, this protein is 54 percent identical at the amino acid level to cellular retinol-binding ..
- METABOLISM OF PHOSPHOLIPID MOLECULAR SPECIESMitchell Robinson; Fiscal Year: 1991..Experiments at the cellular level will measure the rates at which fatty alcohols, fatty acids and glycerol are incorporated into individual species of phospholipids...
- Ichthyosis in Sjogren-Larsson SyndromeWilliam B Rizzo; Fiscal Year: 2010..and are hypothesized to arise from the deranged metabolism of fatty aldehydes and precursor lipids such as fatty alcohols, which cannot be metabolized by FALDH...
- SYNTHESIS OF ANNONACEOUS ACETOGENINS AND ANALOGUESJames Marshall; Fiscal Year: 2001..The synthetic approach will employ chiral allylic and allenic organometal reagents to introduce stereogenic centers with concurrent formation of carbon-carbon bonds. ..
- Synthesis of Tumor Inhibitory Marine Natural ProductsJames Marshall; Fiscal Year: 2004..The main chemical issues to be addressed include the control of stereochemistry by means of chiral organometal chemistry and the design of new and efficient routes to structurally novel natural products. ..
- 2D-HPLC-Tandem Mass Spectrometer for ProteomicsRichard van Breemen; Fiscal Year: 2005..Overall, the proposed 2D mu LC-MS/MS instrument will complement the existing proteomics resources on campus and will enhance the current research of NIH-funded users by providing analytical capabilities currently unavailable on campus. ..
- Botanicals from Central America for MenopauseGail Mahady; Fiscal Year: 2005..Successful validation and standardization of traditional plant-based medicines used to treat menopause has great significance not only for the women of Central America but the rest of the world as well. ..
- Surfactant protein variants in pediatric lung injuryNeal Thomas; Fiscal Year: 2006..unreadable] [unreadable]..
- HPLC time-of-flight mass spectrometer for accurate mass measurementsRichard van Breemen; Fiscal Year: 2007..to natural product chemists and synthetic organic chemists in the user community who rely upon rapid analyses of their compounds in order to advance with their NIH-funded research programs [unreadable] [unreadable] [unreadable]..
- Mechanisms of prostate cancer prevention by lycopeneRichard van Breemen; Fiscal Year: 2007..These human studies will provide vital information for the design of future clinical trials investigating the chemoprevention of prostate cancer by lycopene. [unreadable] [unreadable] [unreadable]..
- Preliminary Study of Safety and Efficacy of Policosanol for Dyslipidemia in HIVBarbara Swanson; Fiscal Year: 2007..unreadable] [unreadable]..
- Marine Natural Products 2008 Gordon Research ConferencePHIL CREWS; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- The Bioavilaibility of Folate in HumansRichard van Breemen; Fiscal Year: 2004..Our new LC-MS-MS assay and the use of 13C-labeled folate species will provide new and more detailed information on the uptake, metabolism, and bioavailability of folates than has been possible previously. ..
- Conference on Emerging Research TechnologiesGail Mahady; Fiscal Year: 2004....
- MATRIX-ASSISTED LASER DESORPTION TOF MASS SPECTROMETERRichard van Breemen; Fiscal Year: 2001..abstract_text> ..
- DEVELOPMENT OF LIGAND ASSISTED ASYMMETRIC SYNTHESESArun Ghosh; Fiscal Year: 2001..Besides the broad range of scope and generality, this line of research will provide excellent opportunities to teach and train graduate and undergraduate students in the laboratory. ..
- EVALUATION OF BOTANICALS FOR H .PYLORI INFECTIONSGail Mahady; Fiscal Year: 2002..pylori strains. Active extracts will be utilized for in vivo studies. The long-term objectives are to develop safe and effective botanical extracts for the treatment and prevention of H. pylori infections. ..
- DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORSArun K Ghosh; Fiscal Year: 2010..This research integrates organic synthesis, protein-ligand x-ray crystallography, molecular modeling and in-depth virus and cell-biological studies to design the next generation of HIV-1 protease inhibitors. ..
- Docosanol and Acyclovir for Treating Genital HerpesLAURA POPE; Fiscal Year: 2003..If proven safe and effective, it would provide a new single agent treatment as well as allow concurrent use with acyclovir. PROPOSED COMMERCIAL APPLICATION: Topical treatment for recurrent genital herpes infections. ..
- MATHEMATICAL MODELING IN NUTRITIONJames Hargrove; Fiscal Year: 2003..Lastly, a panel will discuss the use of modeling in undergraduate and graduate education, and will make recommendations for appropriate activities of a new Research Interest Section on Mathematical Modeling. ..
- Anti-Trypanosomal Agents from a Neotropical CloudforestWILLIAM SETZER; Fiscal Year: 2004..The long-term benefit of this research project is the development of new medicines to treat patients with Chagas disease. ..
- Botanicals for Chlamydia pneumonia infections-Revision 1Gail Mahady; Fiscal Year: 2005..Data and active standardized extracts developed during this work will be used as the basis for future clinical trials. ..
- Acquisition of a Varian 600 MHz High-Resolution NMRPHIL CREWS; Fiscal Year: 2004..The instrument and its complement of probes will be essential for maintaining modern research with competitive throughput and the training of our students in a modern research environment. ..
- Purchase of a 600 MHz NMR Spectrometer with CryoprobeDENNIS CURRAN; Fiscal Year: 2007..This research often requires sophisticated NMR experiments on small samples, and the requested 600 MHz spectrometer will greatly expedite ongoing and planned work. [unreadable] [unreadable] [unreadable]..
- RADICAL REACTIONS FOR NATURAL PRODUCTSDENNIS CURRAN; Fiscal Year: 2002....
- FLUOROUS METHODS FOR TRADITIONAL AND PARALLEL SYNTHESISDENNIS CURRAN; Fiscal Year: 2003..In short, the work will help to move the very young field of fluorous chemistry from infancy into childhood. ..