unsaturated dietary fats

Summary

Summary: Unsaturated fats or oils used in foods or as a food.

Top Publications

  1. ncbi Dietary fat and postmenopausal invasive breast cancer in the National Institutes of Health-AARP Diet and Health Study cohort
    Anne C M Thiebaut
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Executive Plaza South Rm 3033, Bethesda, MD 20892, USA
    J Natl Cancer Inst 99:451-62. 2007
  2. ncbi Effect of dietary alpha-linolenic acid on the activity and gene expression of hepatic fatty acid oxidation enzymes
    T Ide
    Laboratory of Nutrition Biochemistry, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, Tsukuba, Japan
    Biofactors 13:9-14. 2000
  3. ncbi Diet and rheumatoid arthritis: a review of the literature
    Lisa K Stamp
    Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, New Zealand
    Semin Arthritis Rheum 35:77-94. 2005
  4. ncbi Dietary factors and growth and metabolism in experimental tumors
    Leonard A Sauer
    Bassett Research Institute, Cooperstown, NY 13326, USA
    J Nutr Biochem 18:637-49. 2007
  5. ncbi Docosahexaenoic acid suppresses the activity of peroxisome proliferator-activated receptors in a colon tumor cell line
    Joo Y Lee
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Biochem Biophys Res Commun 298:667-74. 2002
  6. ncbi The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial
    Maria Isabel Covas
    Municipal Institute for Medical Research, Barcelona, Spain
    Ann Intern Med 145:333-41. 2006
  7. ncbi Dietary fatty acids and cancer
    D P Rose
    Division of Nutrition and Endocrinology, American Health Foundation, Valhalla, NY 10595, USA
    Am J Clin Nutr 66:998S-1003S. 1997
  8. ncbi Hypertension is related to the degradation of dietary frying oils
    Federico Soriguer
    Servicio de Endocrinologia y Nutricion, Hospital Civil Hospital Universitario Carlos Haya, Plaza del Hospital Civil, 29009 Malaga, Spain
    Am J Clin Nutr 78:1092-7. 2003
  9. ncbi Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil
    Paola Bogani
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Atherosclerosis 190:181-6. 2007
  10. ncbi Total antioxidant capacity of plant foods, beverages and oils consumed in Italy assessed by three different in vitro assays
    Nicoletta Pellegrini
    Department of Public Health, University of Parma, Parma, Italy
    J Nutr 133:2812-9. 2003

Research Grants

  1. Fatty Acids and Cardiovascular Health
    Dariush Mozaffarian; Fiscal Year: 2007
  2. Brain DHA, Dopamine, and Behavior: Roles in ADHD
    Beth Levant; Fiscal Year: 2006
  3. Brain LC-PUFAs and Maternal Mental Health
    Beth Levant; Fiscal Year: 2006
  4. NSAID Inhibition of Alzheimer Pathology: Role of DHA
    Gregory M Cole; Fiscal Year: 2010
  5. Psychoneuroimmunology and Mind-Body Interventions
    Janice Kiecolt Glaser; Fiscal Year: 2006
  6. Psychoneuroimmunology and Mind-Body Medicine
    Janice Kiecolt Glaser; Fiscal Year: 2005
  7. Pregnancy Related Weight Gain: A Link to Obesity
    Anna Maria Siega Riz; Fiscal Year: 2006
  8. Brucella, Aging and Role of IL-17 in Host Defense
    Kevin High; Fiscal Year: 2005
  9. Modeling Antipsychotic-Induced Weight Gain in Rats
    John Fernstrom; Fiscal Year: 2005
  10. Institutional Clinical /Translational Science Awards
    John Clore; Fiscal Year: 2006

Detail Information

Publications218 found, 100 shown here

  1. ncbi Dietary fat and postmenopausal invasive breast cancer in the National Institutes of Health-AARP Diet and Health Study cohort
    Anne C M Thiebaut
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Executive Plaza South Rm 3033, Bethesda, MD 20892, USA
    J Natl Cancer Inst 99:451-62. 2007
    ..Although ecologic association and animal studies support a direct effect of dietary fat on the development of breast cancer, results of epidemiologic studies have been inconclusive...
  2. ncbi Effect of dietary alpha-linolenic acid on the activity and gene expression of hepatic fatty acid oxidation enzymes
    T Ide
    Laboratory of Nutrition Biochemistry, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, Tsukuba, Japan
    Biofactors 13:9-14. 2000
    ..It was suggested that both substrate specificities and alterations in the activities of the enzymes in beta-oxidation pathway play a significant role in the regulation of the serum lipid concentrations in rats fed alpha-18:3...
  3. ncbi Diet and rheumatoid arthritis: a review of the literature
    Lisa K Stamp
    Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, New Zealand
    Semin Arthritis Rheum 35:77-94. 2005
    ..A large number of patients seek alternative or complementary therapies of which diet is an important component. This article reviews the evidence for diet in rheumatoid arthritis along with the associated concept of oral tolerization...
  4. ncbi Dietary factors and growth and metabolism in experimental tumors
    Leonard A Sauer
    Bassett Research Institute, Cooperstown, NY 13326, USA
    J Nutr Biochem 18:637-49. 2007
    ....
  5. ncbi Docosahexaenoic acid suppresses the activity of peroxisome proliferator-activated receptors in a colon tumor cell line
    Joo Y Lee
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Biochem Biophys Res Commun 298:667-74. 2002
    ..These results suggest that PPAR-mediated gene expression and cellular responses can be dynamically modulated by different types of dietary fatty acids consumed...
  6. ncbi The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial
    Maria Isabel Covas
    Municipal Institute for Medical Research, Barcelona, Spain
    Ann Intern Med 145:333-41. 2006
    ..Little information is available on the effect of the phenolic compounds of olive oil on plasma lipid levels. No international study with a large sample size has been done...
  7. ncbi Dietary fatty acids and cancer
    D P Rose
    Division of Nutrition and Endocrinology, American Health Foundation, Valhalla, NY 10595, USA
    Am J Clin Nutr 66:998S-1003S. 1997
    ....
  8. ncbi Hypertension is related to the degradation of dietary frying oils
    Federico Soriguer
    Servicio de Endocrinologia y Nutricion, Hospital Civil Hospital Universitario Carlos Haya, Plaza del Hospital Civil, 29009 Malaga, Spain
    Am J Clin Nutr 78:1092-7. 2003
    ..The family kitchen resembles an uncontrolled laboratory experiment, and some discrepancies in the relation between the risk of hypertension and dietary fat may be partly due to the manipulation to which the fats were subjected...
  9. ncbi Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil
    Paola Bogani
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Atherosclerosis 190:181-6. 2007
    ..These data reinforce the notion that the Mediterranean diet reduces the incidence of coronary heart disease partially due to the protective role of its phenolic components, including those of extra virgin olive oil...
  10. ncbi Total antioxidant capacity of plant foods, beverages and oils consumed in Italy assessed by three different in vitro assays
    Nicoletta Pellegrini
    Department of Public Health, University of Parma, Parma, Italy
    J Nutr 133:2812-9. 2003
    ..Such data, coupled with an appropriate questionnaire to estimate antioxidant intake, will allow the investigation of the relation between dietary antioxidants and oxidative stress-induced diseases...
  11. ncbi Cis-polyunsaturated fatty acids stimulate beta1 integrin-mediated adhesion of human breast carcinoma cells to type IV collagen by activating protein kinases C-epsilon and -mu
    R Palmantier
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 61:2445-52. 2001
    ..Altogether, these data suggest that cis-PUFAs enhance human breast cancer cell adhesion to collagen IV by selectively activating specific PKC isozymes, which leads to the activation of beta1 integrins...
  12. ncbi Dietary red palm oil reduces ischaemia-reperfusion injury in rats fed a hypercholesterolaemic diet
    Maritza J Kruger
    Department of Physiological Sciences, University of Stellenbosch, Stellenbosch, 7600, South Africa
    Br J Nutr 97:653-60. 2007
    ..This significant reduction in p38-MAPK was also associated with reduced apoptosis as indicated by significant reductions in caspase-3 and poly(ADP-ribose) polymerase cleavage...
  13. ncbi The scientific evidence for a beneficial health relationship between walnuts and coronary heart disease
    Elaine B Feldman
    Medical College of Georgia, Augusta, GA, USA
    J Nutr 132:1062S-1101S. 2002
    ....
  14. ncbi An integrative metabolism approach identifies stearoyl-CoA desaturase as a target for an arachidonate-enriched diet
    David M Mutch
    Nestle Research Center, Vers chez les Blanc, Lausanne, Switzerland
    FASEB J 19:599-601. 2005
    ....
  15. ncbi Dietary fish oil positively regulates plasma leptin and adiponectin levels in sucrose-fed, insulin-resistant rats
    Andrea S Rossi
    Dept of Biochemistry, School of Biochemistry, University of Litoral, Ciudad Universitaria, Paraje El Pozo C C 242, 3000 Santa Fe, Argentina
    Am J Physiol Regul Integr Comp Physiol 289:R486-R494. 2005
    ..These results suggest that increasing both adipokines by dietary FO might play an essential role in the normalization of insulin resistance and adiposity in dietary-induced, insulin-resistant models...
  16. ncbi Suppression of fatty acid synthase promoter by polyunsaturated fatty acids
    Yang Soo Moon
    Department of Nutritional Sciences, University of California, Berkeley, CA 94720, USA
    J Lipid Res 43:691-8. 2002
    ..Using HepG2 cells, we further examined the specific FAS promoter elements required for PUFA suppression. We found that the -150 SRE, as well as the -65 E-Box, contribute to PUFA suppression of the FAS promoter, at least in vitro...
  17. ncbi Dietary virgin olive oil protects against lipid peroxidation and improves antioxidant status in the liver of rats chronically exposed to ethanol
    Abir Kasdallah-Grissa
    Faculty of Medicine, Laboratory of Biochemistry, UR03 ES 08 Human Nutrition and Metabolic Disorders, Monastir 5019, Tunisia
    Nutr Res 28:472-9. 2008
    ..In conclusion, results of this study indicate that olive oil ingestion by rats protects the liver from ethanol-induced oxidative damage by affecting the cellular redox potential...
  18. ncbi Vasculoprotective effects of oleic acid: epidemiological background and direct vascular antiatherogenic properties
    M Massaro
    Laboratory for Thrombosis and Vascular Research, CNR Institute of Clinical Physiology, Pisa, Italy
    Nutr Metab Cardiovasc Dis 12:42-51. 2002
    ....
  19. ncbi Dietary alpha-linolenic acid-rich diacylglycerols reduce body weight gain accompanying the stimulation of intestinal beta-oxidation and related gene expressions in C57BL/KsJ-db/db mice
    Takatoshi Murase
    Biological Science Laboratories, Kao Corporation, Ichikai, Haga, Tochigi 321 3497, Japan
    J Nutr 132:3018-22. 2002
    ..In addition, structural differences between DG and TG, not variations in the composition of fatty acids, are responsible for the different effects of the lipids...
  20. ncbi Effects of dietary fatty acids on the composition and oxidizability of low-density lipoprotein
    M Kratz
    Institute of Arteriosclerosis Research at the University of Münster, Munster, Germany
    Eur J Clin Nutr 56:72-81. 2002
    ..The objective of this study was to compare the effects of dietary monounsaturated fatty acids (MUFA), n-6 and n-3 polyunsaturated fatty acids (PUFA) on LDL composition and oxidizability...
  21. ncbi Age-related mitochondrial DNA deletion in rat liver depends on dietary fat unsaturation
    Jose L Quiles
    Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, Spain
    J Gerontol A Biol Sci Med Sci 61:107-14. 2006
    ..Results suggest that the age-related increase of the relative amount of deleted mtDNA depends on fat unsaturation. Moreover, the studied mtDNA deletion was correlated with mitochondrial oxidative stress and ultrastructural alterations...
  22. ncbi Chemistry of deep-fat frying oils
    E Choe
    Dept of Food and Nutrition, Inha Univ, Incheon, Korea
    J Food Sci 72:R77-86. 2007
    ..Antioxidant decreases the frying oil oxidation, but the effectiveness of antioxidant decreases with high frying temperature. Lignan compounds in sesame oil are effective antioxidants in deep-fat frying...
  23. ncbi Biological properties of olive oil phytochemicals
    Francesco Visioli
    University of Milan, Department of Pharmacological Sciences, Italy
    Crit Rev Food Sci Nutr 42:209-21. 2002
    ....
  24. ncbi Flaxseed oil and inflammation-associated bone abnormalities in interleukin-10 knockout mice
    Stacey L Cohen
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 3E2
    J Nutr Biochem 16:368-74. 2005
    ....
  25. ncbi Differential regulation of hepatic apoptotic pathways by dietary olive and sunflower oils in the aging rat
    Rosario I Bello
    Departamento de Biologia Celular, Fisiologia e Inmunologia, Facultad de Ciencias, Universidad de Cordoba, Córdoba 14014, Spain
    Exp Gerontol 41:1174-84. 2006
    ....
  26. ncbi Anti-microinflammatory lipid signals generated from dietary N-3 fatty acids via cyclooxygenase-2 and transcellular processing: a novel mechanism for NSAID and N-3 PUFA therapeutic actions
    C N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Physiol Pharmacol 51:643-54. 2000
    ..Moreover, they provide novel mechanism(s) that could underlie the many reported therapeutic benefits of omega-3 dietary supplementation of interest in inflammation, cancer, and vascular disorders...
  27. ncbi A long-term seal- and cod-liver-oil supplementation in hypercholesterolemic subjects
    J Brox
    Department of Clinical Chemistry, University Hospital of Tromsø, Norway
    Lipids 36:7-13. 2001
    ....
  28. pmc The effect of dietary red palm oil on the functional recovery of the ischaemic/reperfused isolated rat heart: the involvement of the PI3-kinase signaling pathway
    Anna Mart Engelbrecht
    Department of Physiological Sciences, University of Stellenbosch, South Africa
    Lipids Health Dis 8:18. 2009
    ..9 +/- 3.4 pixels in RPO + Wm). We have also demonstrated that PI3-K inhibition induced PARP cleavage (marker of apoptosis) in the hearts during ischaemia/reperfusion injury and that RPO supplementation counteracted this effect...
  29. ncbi Lipid hydroperoxides from processed dietary oils enhance growth of hepatocarcinoma cells
    Nataliya V Rohr-Udilova
    Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria
    Mol Nutr Food Res 52:352-9. 2008
    ..2 cells, indicating the protective role of HO-1 induction. This is the first evidence that lipid hydroperoxides of dietary origin may be an important driving force for carcinogenesis in the liver...
  30. ncbi Dietary docosahexaenoic acid and immunocompetence in young healthy men
    D S Kelley
    USDA, ARS, Western Human Nutrition Research Center, Presidio of San Francisco, California 94129, USA
    Lipids 33:559-66. 1998
    ..Our results show that when total fat intake is low and held constant, DHA consumption does not inhibit many of the lymphocyte functions which have been reported to be inhibited by fish oil consumption...
  31. ncbi Palm fruit chemistry and nutrition
    Kalyana Sundram
    Malaysian Palm Oil Board, P O Box 10620, 50720 Kuala Lumpur, Malaysia
    Asia Pac J Clin Nutr 12:355-62. 2003
    ..A further challenge would be to package all these palm ingredients into a single functional food for better nutrition and health...
  32. ncbi Dietary polyunsaturated fatty acids and cancers of the breast and colorectum: emerging evidence for their role as risk modifiers
    H Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Carcinogenesis 20:2209-18. 1999
    ....
  33. ncbi Phenolic compounds and squalene in olive oils: the concentration and antioxidant potential of total phenols, simple phenols, secoiridoids, lignansand squalene
    R W Owen
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Food Chem Toxicol 38:647-59. 2000
    ..29 +/- 2.56). All classes of phenolics were shown to be potent antioxidants. In future epidemiologic studies, both the nature and source of olive oil consumed should be differentiated in ascertaining cancer risk...
  34. ncbi Diets rich in saturated and polyunsaturated fatty acids: metabolic shifting and cardiac health
    Yeda Sant ana Diniz
    Department of Clinical Cardiology, Faculty of Medicine, University of Sao Paulo State, Botucatu, Sao Paulo, Brazil
    Nutrition 20:230-4. 2004
    ..The aim of this study was to determine the effects of diets rich in saturated and polyunsaturated fatty acids on metabolic pathways and the relation of metabolic shifting to oxidative stress in cardiac tissue...
  35. ncbi Dietary PUFA and the metabolic syndrome in Indian Asians living in the UK
    Louise M Brady
    Hugh Sinclair Human Nutrition Unit, School of Food Biosciences, PO Box 226, University of Reading, White Knights, Reading RG6 6AP, UK
    Proc Nutr Soc 63:115-25. 2004
    ..The present study concludes that, contrary to the central hypothesis, the prevalence of metabolic abnormalities in Indian Asians compared with Caucasians may not be attributable to differences in intakes of n-6 and n-3 PUFA...
  36. ncbi Biohydrogenation of dietary n-3 PUFA and stability of ingested vitamin E in the rumen, and their effects on microbial activity in sheep
    S Chikunya
    ASRC, Harper Adams University College, School of Agriculture, Edgmond, Newport, Shropshire TF10 8NB, UK
    Br J Nutr 91:539-50. 2004
    ..Although alpha-tocopheryl acetate resisted degradation in the rumen, plasma vitamin E status remained deficient to borderline, suggesting either that uptake may have been impaired or metabolism post-absorption increased...
  37. ncbi Effects of dietary n-3 polyunsaturated fatty acids, breed and dietary vitamin E on the fatty acids of lamb muscle, liver and adipose tissue
    G Demirel
    Division of Farm Animal Science, School of Veterinary Science, University of Bristol, Langford, Bristol BS40 5DU, UK
    Br J Nutr 91:551-65. 2004
    ..Different combinations of dietary fatty acids and better protection against rumen biohydrogenation are required to improve muscle PUFA : saturated fatty acids ratios...
  38. ncbi Virgin olive oil normalizes the altered triacylglycerol molecular species composition of adipose tissue in spontaneously hypertensive rats
    Javier S Perona
    Instituto de la Grasa CSIC, Avenida Padre Garcia Tejero 4, 41012 Seville, Spain
    J Agric Food Chem 52:4227-33. 2004
    ..Therefore, it was concluded that although oleic acid-rich diets improve some of the altered parameters of SHR adipose tissue, VOO is more effective than HOSO in this regard...
  39. ncbi Dietary intake of essential and long-chain polyunsaturated fatty acids in pregnancy
    Elizabeth D Loosemore
    University of Connecticut, Department of Nutritional Sciences, Storrs, CT 06269 4017, USA
    Lipids 39:421-4. 2004
    ..We conclude that replacing dietary sources of SFA with those of EFA and LCPUFA, especially n-3 LCPUFA, would benefit the dietary fat profiles of all pregnant women...
  40. ncbi Influence of dietary lipid source and strain on fatty acid composition of Muscovy duck meat
    A Schiavone
    Dipartimento di Produzioni Animali, Epidemiologia ed Ecologia, Universita di Torino, Grugliasco, Italy
    J Anim Physiol Anim Nutr (Berl) 88:88-93. 2004
    ..e. off-flavours) must be evaluated...
  41. ncbi Influence of parturition and diets enriched in n-3 or n-6 polyunsaturated fatty acids on immune response of dairy cows during the transition period
    M Lessard
    Dairy and Swine Research and Development Centre, Agriculture and Agri Food Canada, Lennoxville, QC, Canada J1M 1Z3
    J Dairy Sci 87:2197-210. 2004
    ..In conclusion, functional properties of lymphocytes and monocyte/macrophage lineage of dairy cows during the transition period are modulated by parturition and the composition of polyunsaturated fatty acids in the diet...
  42. ncbi Effects of dietary fat and oxidized cholesterol on gene expression in rat liver as assessed by cDNA expression array analysis
    Robert Ringseis
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhalden Strasse 26, 06108, Halle Saale, Germany
    Eur J Nutr 44:231-41. 2005
    ..However, the various biological effects of oxysterols such as cytotoxicity, atherogenicity or mutagenicity suggest that other genes may be also affected by oxysterols than lipid metabolism...
  43. ncbi The Mediterranean vs the Japanese diet
    S Tokudome
    Eur J Clin Nutr 58:1323; author reply 1324-5. 2004
  44. ncbi Dietary fatty acid composition affects the repeat swimming performance of Atlantic salmon in seawater
    G N Wagner
    Faculty of Agricultural Science, University of British Columbia, 266B 2357 Main Mall, Vancouver, BC Canada V6T 1Z4
    Comp Biochem Physiol A Mol Integr Physiol 137:567-76. 2004
    ..g. SO diet). Lipid supplements consisting largely of vegetable oils did not compromise fish cardiorespiratory physiology under the conditions of this study...
  45. ncbi Restoration of depressed prostanoid-induced ileal contraction in spontaneously hypertensive rats by dietary fish oil
    Glen S Patten
    CSIRO Health Sciences and Nutrition, Adelaide, South Australia 5000, Australia
    Lipids 40:69-79. 2005
    ....
  46. ncbi [Unsaturated fatty acids intake and breast cancer risk: epidemiological data review]
    Anne C M Thiebaut
    Equipe E3N EPIC, INSERM, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex
    Bull Cancer 92:658-69. 2005
    ..However, it is difficult in human to disentangle the effect of nutrient intake from that of contributing foods or even nutritional profile...
  47. ncbi Fish-oil esters of plant sterols improve the lipid profile of dyslipidemic subjects more than do fish-oil or sunflower oil esters of plant sterols
    Isabelle Demonty
    School of Dietetics and Human Nutrition, McGill University, Sainte Anne de Bellevue, Canada
    Am J Clin Nutr 84:1534-42. 2006
    ..Fish-oil fatty acid esters of plant sterols (FO-PS) were shown to have hypotriglyceridemic and hypocholesterolemic properties in animal models...
  48. ncbi Fatty acids in liver, muscle and gonad of three tropical rays including non-methylene-interrupted dienoic fatty acids
    Mohamed Vall Ould El Kebir
    Laboratoire de Phytochimie de Marseille, UMR CNRS 6171, Faculte des Sciences et Techniques de Saint Jerome, Universite Paul Cezanne, Case 531, Avenue Escadrille Normandie Niemen, 13397 Marseille Cedex 20, France
    Lipids 42:525-35. 2007
    ..These acids are quite unusual in fish and unprecedented in rays. The 22:2 Delta6,14 acid occurred in gonads of male specimens of R. cemiculus at 2.9%...
  49. ncbi The effects of feeding fish oil on uterine secretion of PGF2alpha, milk composition, and metabolic status of periparturient Holstein cows
    R Mattos
    Department of Animal Sciences, University of Florida, Gainesville 32611 0920, USA
    J Dairy Sci 87:921-32. 2004
    ..Feeding FO reduced plasma concentrations of glucose. Dietary fatty acids given during the periparturient period can reduce the uterine secretion of PGF2alpha in lactating dairy cows and alter the fatty acid profile of milk fat...
  50. ncbi Replacement of dietary fish oils by alpha-linolenic acid-rich oils lowers omega 3 content in tilapia flesh
    Ioannis T Karapanagiotidis
    Institute of Aquaculture, University of Stirling, Stirling, FK9 4LA, Scotland
    Lipids 42:547-59. 2007
    ....
  51. ncbi Immune modulation by parenteral lipid emulsions
    Geert J A Wanten
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Am J Clin Nutr 85:1171-84. 2007
    ....
  52. ncbi Importance of seafood as nutrient source in the diet of Belgian adolescents
    I Sioen
    Department of Public Health, and Department of Food Safety and Food Quality, Ghent University, Ghent, Belgium
    J Hum Nutr Diet 20:580-9. 2007
    ..The aim of this study was to investigate the importance of seafood as a nutrient source in adolescents' diet and the extent to which seafood consumption can increase the intake of omega-3 polyunsaturated fatty acids and vitamin D...
  53. ncbi The effect of dietary fish oil-supplementation to healthy young men on oxidative burst measured by whole blood chemiluminescence
    Stine Bartelt
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Rolighedsvej 30, DK 1958 Frederiksberg C, Denmark
    Br J Nutr 99:1230-8. 2008
    ..44, P = 0.016), suggesting a dose-response relationship. These results indicate that n-3 LCPUFA may have immuno-stimulating effects...
  54. ncbi Mechanisms by which botanical lipids affect inflammatory disorders
    Floyd H Chilton
    Center for Botanical Lipids, Wake Forest University, Winston Salem, NC, USA
    Am J Clin Nutr 87:498S-503S. 2008
    ..Echium oil and other oils containing stearidonic acid as well as botanical oil combinations (such as echium and borage oils) hold great promise for modulating inflammatory diseases...
  55. ncbi Replacement of dietary fish oil for Atlantic salmon parr (Salmo salar L.) with a stearidonic acid containing oil has no effect on omega-3 long-chain polyunsaturated fatty acid concentrations
    Matthew R Miller
    School of Aquaculture, Tasmanian Aquaculture and Fisheries Institute, University of Tasmania, Locked Bag 1370, Launceston, Tasmania, Australia
    Comp Biochem Physiol B Biochem Mol Biol 146:197-206. 2007
    ..The balance between increased biosynthesis and retention of omega3 LC-PUFA to maintain the concentrations observed in the SO fed fish remains to be conclusively determined, and further studies are needed to ascertain this...
  56. ncbi Partial replacement of dietary fish oil with blends of vegetable oils (rapeseed, linseed and palm oils) in diets for European sea bass (Dicentrarchus labrax L.) over a long term growth study: effects on muscle and liver fatty acid composition and effectiv
    G Mourente
    Departamento de Biologia, Facultad de Ciencias del Mar y Ambientales, Universidad de Cadiz, E 11510 Puerto Real Cádiz, Spain
    Comp Biochem Physiol B Biochem Mol Biol 145:389-99. 2006
    ..95 g of EPA+DHA for fish fed FO or 60% VO, respectively. Therefore, sea bass grown for most of the production cycle using diets containing 60% VO can still contribute a significant quantity of healthy n-3 HUFA to the human consumer...
  57. ncbi Oily fish reduces plasma triacylglycerols: a primary prevention study in overweight men and women
    Carmel S Moore
    Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
    Nutrition 22:1012-24. 2006
    ..It tested whether decreases in LA:LNA modulate effects of LC omega-3 PUFA...
  58. ncbi [Dietary fatty acids and experimental carcinogenesis]
    Philippe Bougnoux
    INSERM E 0211, Equipe de recherche Nutrition, Croissance et Cancer, CORAD, CHU de Tours 2, boulevard Tonnellé 37044 Tours Cedex
    Bull Cancer 92:685-96. 2005
    ..On the other hand, an excessive consumption of n-6 PUFAs and of saturated fatty acids could promote colon cancers...
  59. ncbi Influence of dietary fats on weight gain in albino rats
    Nandita Pereira
    Department of Physiology, Goa Medical College, Bambolim, Goa 403 202
    Indian J Physiol Pharmacol 49:206-12. 2005
    ..001), yet weight gain was similar. Thus it appears that carbon-chain length and degree of saturation of dietary fat does not influence weight gain in rats fed an ad libitum diet...
  60. ncbi Does enteral nutrition of dietary polyunsaturated fatty acids promote oxidative stress and tumour growth in ductal pancreatic cancer? Experimental trial in Syrian Hamster
    J I Gregor
    Clinic of General, Visceral, Vascular and Thoracic Surgery, Charite Campus Mitte, Humbold University of Berlin, 10117 Berlin, Germany
    Prostaglandins Leukot Essent Fatty Acids 74:67-74. 2006
    ..Thus we investigated the effects of n-3, n-6 and n-9 polyunsaturated fatty acids (PUFA) on oxidative stress (lipidperoxidation) and tumour growth in ductal pancreatic cancer...
  61. ncbi High-concentrate diets and polyunsaturated oils alter trans and conjugated isomers in bovine rumen, blood, and milk
    J J Loor
    Herbivore Research Unit INRA Theix, 63122 St Genes Champanelle, France
    J Dairy Sci 88:3986-99. 2005
    ....
  62. ncbi Paradoxical effect of n-3-containing vegetable oils on long-chain n-3 fatty acids in rat heart
    Leslie G Cleland
    Hanson Institute and Rheumatology Unit, Royal Adelaide Hospital, SA, Australia
    Lipids 40:995-8. 2005
    ..e., flaxseed > echium > canola > sunflower oil. This paradox may be explained by lower ALA intake leading to decreased competition for Delta6 desaturase activity between ALA and the 24:5n-3 FA precursor to DHA formation...
  63. ncbi Effects of dietary saturated, monounsaturated, and n-3 fatty acids on blood pressure in healthy subjects
    Birthe M Rasmussen
    Department of Clinical Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus, Denmark
    Am J Clin Nutr 83:221-6. 2006
    ..Although the effect of diet on plasma lipids and lipoproteins is well documented, less information exists on the role of fats on blood pressure (BP)...
  64. ncbi The influence of chylomicron remnants on cholesteryl ester metabolism in cultured rat hepatocytes: comparison of the effects of particles enriched in n-3 or n-6 polyunsaturated fatty acids
    K M Botham
    Department of Physiology, University of the Basque Country, Medical School, Bilbao, Spain
    Biochim Biophys Acta 1534:96-109. 2001
    ....
  65. ncbi Phospholipid fatty acid composition and diamine oxidase activity of intestinal mucosa from rats treated with irinotecan hydrochloride (CPT-11) under vegetable oil-enriched diets: comparison between perilla oil and corn oil
    Makoto Usami
    Division of Surgical Metabolism, Faculty of Health Science, Kobe University School of Medicine, 7 10 2 Tomogaoka, Suma ku, Kobe 654 0142, Japan
    JPEN J Parenter Enteral Nutr 30:124-32. 2006
    ..The effect of dietary vegetable oil supplementation, perilla oil vs corn oil, was also evaluated...
  66. ncbi Digestion and deposition of individual fatty acids in growing-finishing pigs fed diets containing either beef tallow or sunflower oil
    J Mitchaothai
    Department of Clinic for Swine, Faculty of Veterinary Medicine, Mahanakorn University of Technology, Nong Chok, Bangkok, Thailand
    J Anim Physiol Anim Nutr (Berl) 92:502-10. 2008
    ..It is concluded that the feeding of a diet with sunflower oil instead of beef tallow improved apparent digestibility of SFA, MUFA and PUFA, increased the deposition:digestible intake ratio for SFA, but lowered that for MUFA and PUFA...
  67. ncbi Astrocytes in culture require docosahexaenoic acid to restore the n-3/n-6 polyunsaturated fatty acid balance in their membrane phospholipids
    Gaelle Champeil-Potokar
    Laboratoire de Nutrition et Securite Alimentaire, Institut National de la Recherche Agronomique, Jouy en Josas, France
    J Neurosci Res 75:96-106. 2004
    ..This reliable method of altering membrane phospholipid composition promises to be useful for studying the influence of n-6/n-3 imbalance on astrocyte function...
  68. ncbi [Possibilities for correction of n-3 fatty acids insufficiency in the Hungarian population]
    József Perédi
    Elelmiszertudományi Kar, Gabona és Iparinövény Technológiai Tanszék, Szent Istvan Egyetem, Budapest
    Orv Hetil 143:2587-91. 2002
    ..The author has presented presumable reasons of this deficiency, and has highlighted that production, marketing and consumption of special 'functional foods', rich in n-3 fatty acids may considerably improve this unfavourable situation...
  69. ncbi Effect of dietary polyunsaturated fatty acids on uterine prostaglandin synthesis in the cow
    Z Cheng
    Reproduction and Development Group, Department of Veterinary Basic Sciences, Royal Veterinary College, Boltons Park, Hawkshead Road, Potters Bar, Hertfordshire EN6 1NB, UK
    J Endocrinol 171:463-73. 2001
    ..These data suggest that a high n-6 diet reduces the endometrial capacity to produce PGs and may therefore have implications for the control of luteolysis and other PG-mediated events such as ovulation...
  70. ncbi Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects
    Yvonne E Finnegan
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, United Kingdom
    Am J Clin Nutr 77:783-95. 2003
    ....
  71. ncbi n-3 Deficient and docosahexaenoic acid-enriched diets during critical periods of the developing prenatal rat brain
    Mark Schiefermeier
    Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Lipid Res 43:124-31. 2002
    ..Thus the content of fetal brain DHA in n-3 deficient embryos could be restored within 48 hours. Dietary manipulation of fetal tissues is a rapid phenomenon and can be used to enrich DHA at critical periods of development in utero...
  72. ncbi Accumulation of alpha-tocopherol in eggs enriched with omega3 and omega6 polyunsaturated fatty acids
    J Galobart
    Departament de Ciencia Animal i dels Aliments, Facultat Veterinària, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    Poult Sci 81:1873-6. 2002
    ..No differences were observed between dietary oils in the deposition pattern of alpha-Toc in the egg...
  73. ncbi Transfer of n-3 and n-6 polyunsaturated fatty acids from yolk to embryo during development of the king penguin
    F Decrock
    , Centre National de la Recherche Scientifique, , 67087 Strasbourg, France
    Am J Physiol Regul Integr Comp Physiol 280:R843-53. 2001
    ..Thus both 22:6(n-3) and 20:4(n-6), which are, respectively, abundant and deficient in the yolk, undergo biomagnification during transfer to the embryo...
  74. ncbi Maternal dietary N-3 fatty acids alter the spleen fatty acid composition and bovine serum albumin-induced wing web swelling in broilers
    Y W Wang
    Poult Sci 81:1722-7. 2002
    ..In conclusion, n-3 PUFA in breeder hen diets suppressed the BSA-induced wing web swellings of the hens, increased the spleen n-3 fatty acids (especially DHA), and decreased BSA-induced wing web swellings of progeny up to 4 wk of age...
  75. ncbi On the reanalysis of the GISSI-Prevenzione
    Alexander Leaf
    Circulation 105:1874-5. 2002
  76. ncbi Inhibition of intracellular peroxides and apoptosis of lymphocytes in lupus-prone B/W mice by dietary n-6 and n-3 lipids with calorie restriction
    C P Reddy Avula
    University of Texas Health Science Center, Department of Medicine, San Antonio 78229 3900, USA
    J Clin Immunol 22:206-19. 2002
    ..In summary, CR resulted in decreased apoptosis accompanied by alterations in Fas, Fas-L, and Bcl-2 expression in old mice, increased life span, and delayed onset of kidney disease...
  77. ncbi Dietary n-3 and n-6 fatty acids alter avian metabolism: metabolism and abdominal fat deposition
    Ronald E Newman
    Faculty of Veterinary Science, University of Sydney, Camden, NSW, Australia
    Br J Nutr 88:11-8. 2002
    ..In addition, the PUFA-rich diets lowered plasma concentrations of serum triacylglycerols and cholesterol. The findings indicate that dietary fatty acid profile influences nutrient partitioning in broiler chickens...
  78. ncbi Fatty acid compositions of serum phospholipids of postmenopausal women: a comparison between Greenland Inuit and Canadians before and after supplementation with fish oil
    Ken D Stark
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Nutrition 18:627-30. 2002
    ....
  79. ncbi Cardiac membrane fatty acid composition modulates myocardial oxygen consumption and postischemic recovery of contractile function
    Salvatore Pepe
    Cardiac Surgical Research Unit, Alfred Hospital and Baker Medical Research Institute, Monash University Faculty of Medicine, Melbourne, Australia
    Circulation 105:2303-8. 2002
    ..Fish oils modify cardiac membrane phospholipid fatty acid composition with potent antiarrhythmic effects. We tested the effects of dietary fish oil on ventricular hemodynamics and myocardial oxygen consumption (MVO2)...
  80. ncbi Dietary alpha-linolenic acid lowers postprandial lipid levels with increase of eicosapentaenoic and docosahexaenoic acid contents in rat hepatic membrane
    H K Kim
    Department of Food and Nutrition, Seoul National University, Korea
    Lipids 36:1331-6. 2001
    ..These results suggest that n-3 ALA has more of a hypolipidemic effect than n-6 LA and that the hypolipidemic effect of n-3 PUFA may be partly related to the increase of EPA and DHA in hepatic membrane...
  81. ncbi Long-term supplementation of various dietary lipids alters bone mineral content, mechanical properties and histological characteristics of Japanese quail
    D Liu
    Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Poult Sci 82:831-9. 2003
    ..These results suggest that long-term exposure to a FO or HSBO diet have a significant beneficial effect on bone metabolism...
  82. ncbi Reversibility of n-3 fatty acid deficiency-induced alterations of learning behavior in the rat: level of n-6 fatty acids as another critical factor
    A Ikemoto
    Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabedori, Mizuhoku, Nagoya 467-8603, Japan
    J Lipid Res 42:1655-63. 2001
    ....
  83. ncbi Supplementation of postmenopausal women with fish oil does not increase overall oxidation of LDL ex vivo compared to dietary oils rich in oleate and linoleate
    J V Higdon
    Department of Nutrition and Food Management, Oregon State University, Corvallis, OR 97331, USA
    J Lipid Res 42:407-18. 2001
    ..H. Du, Y. S. Lee, T. Wu, and R. C. Wander. Supplementation of postmenopausal women with fish oil does not increase overall oxidation of LDL ex vivo compared to dietary oils rich in oleate and linoleate. J. Lipid Res. 2001. 42: 407--418...
  84. pmc Comparison of the effects of dietary n-3 and n-6 polyunsaturated fatty acids on very-low-density lipoprotein secretion when delivered to hepatocytes in chylomicron remnants
    X Zheng
    Department of Veterinary Basic Sciences, The Royal Veterinary College, Royal College St, London NW1 0TU, UK
    Biochem J 357:481-7. 2001
    ....
  85. ncbi Enhanced level of n-3 fatty acid in membrane phospholipids induces lipid peroxidation in rats fed dietary docosahexaenoic acid oil
    J H Song
    Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, 981-8555, Sendai, Japan
    Atherosclerosis 155:9-18. 2001
    ....
  86. ncbi n-3 enrichment of chicken meat. 1. Use of very long-chain fatty acids in chicken diets and their influence on meat quality: fish oil
    S López-Ferrer
    Department of Ciència Animal i dels Aliments, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Poult Sci 80:741-52. 2001
    ..After 1 wk of T4, the DHA levels in chicken decreased. Sensory panelists could not identify the meats from T4 and T5 as being different from the control diet (T1)...
  87. ncbi Lipid oxidation in fresh and spray-dried eggs enriched with omega3 and omega6 polyunsaturated fatty acids during storage as affected by dietary vitamin E and canthaxanthin supplementation
    J Galobart
    , , , Spain
    Poult Sci 80:327-37. 2001
    ..On the other hand, CX supplementation did not prevent lipid oxidation in PUFA-enriched eggs. Moreover, no synergistic effect between both compounds was detected...
  88. pmc n-3 polyunsaturated fatty acids decrease mucosal/epidermal reactions and enhance antitumour effect of ionising radiation with inhibition of tumour angiogenesis
    B Wen
    , Institut Gustave Roussy, 39, rue Camille Desmoulins, , France
    Br J Cancer 89:1102-7. 2003
    ..The magnitude of the differential effect suggests that n-3 PUFAs need to be further investigated in the clinic...
  89. ncbi Effects of lifestyle modification and lipid intake variations on patients with peripheral vascular disease
    Teresa Nestares
    Institute of Nutrition and Food Technology, Department of Physiology, University of Granada
    Int J Vitam Nutr Res 73:389-98. 2003
    ..The lifestyle intervention program, together with a high intake of olive plus fish oil, seems to produce important beneficial effects in nutritional management, physical performance, and clinical parameters of PVD patients...
  90. ncbi Effects of n-3 polyunsaturated dietary supplementation on the reproductive capacity of male turkeys
    E Blesbois
    Station de Recherches Avicoles, INRA, F 37380 Nouzilly, France
    Theriogenology 61:537-49. 2004
    ..These results indicate that an increase in the dietary ratio of n-3/n-6 PUFAs is valuable to sustain the reproductive capacity of male turkeys especially when they are getting older...
  91. ncbi Altered fatty acid compositions in atlantic salmon (Salmo salar) fed diets containing linseed and rapeseed oils can be partially restored by a subsequent fish oil finishing diet
    J Gordon Bell
    Institute of Aquaculture, University of Stirling, Stirling, FK9 4LA, Scotland, UK
    J Nutr 133:2793-801. 2003
    ....
  92. ncbi [The role of omega-3 fatty acids in the treatment of bipolar disorders: the current situation]
    C Sempels
    Universitair Psychiatrisch Centrum Katholieke Universiteit Leuven, campus Kortenberg, Belgie
    Tijdschr Psychiatr 49:639-47. 2007
    ..Epidemiological investigations show that a high consumption of omega-3 fatty acids is in inverse proportion to the prevalence of affective disorders...
  93. ncbi Omega 6 to omega 3 fatty acid imbalance early in life leads to persistent reductions in DHA levels in glycerophospholipids in rat hypothalamus even after long-term omega 3 fatty acid repletion
    Duo Li
    Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310029, China
    Prostaglandins Leukot Essent Fatty Acids 74:391-9. 2006
    ..The increased ALA and reduced DHA proportions in the animals re-fed ALA in later life are consistent with a dysfunction or down-regulation of the conversion of ALA to 18:4n-3 by the delta-6 desaturase...
  94. ncbi Effect of dietary linoleic acid concentration and vitamin E supplementation on cell desquamation and susceptibility to oxidative damage of pig jejunal mucosa
    C J Lopez Bote
    Producción Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain
    J Anim Physiol Anim Nutr (Berl) 85:22-8. 2001
    ..002). The dietary concentration of C18 : 2 significantly affected oxidation of pig jejunal mucosa (p < 0.002)...
  95. ncbi Membrane lipid composition of pancreatic AR42J cells: modification by exposure to different fatty acids
    Nama a Audi
    Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, Granada, Spain
    Exp Biol Med (Maywood) 232:532-41. 2007
    ..However, differences in baseline characteristics, and perhaps fatty acid metabolism, indicate that results obtained in AR42J cells should be confirmed with experiments in the whole animal...
  96. ncbi Comparative effects of dimethylbenz(a)anthacene and a 15% olive-oil diet on cellular components and expression of apoptosis-related proteins in the spleen and mammary gland tumors of rats
    G Kossoy
    Department of Gynecology and Obstetrics, Kaplan Medical Center, Rehovot, Israel
    Oncol Rep 8:435-9. 2001
    ..This observation may serve as an additional proof of tumor-promoter effects of a high fat diet...
  97. ncbi Trans fatty acids (tFA): sources and intake levels, biological effects and content in commercial Spanish food
    P M Fernández-San Juan
    Sección de Componentes y Aditivos, Centro Nacional de Alimentación, Agencia Española de Seguridad Alimentaria y Nutrición, Majadahonda, Madrid, Spain
    Nutr Hosp 24:515-20. 2009
    ..Our results show that major sources of trans fatty acids in commercial Spanish foods are fast-food (hamburger, French fries), snacks, bakery products (cakes, donuts, biscuits), margarines and dehydrated soups...
  98. ncbi Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle
    Agnieszka Blachnio-Zabielska
    Department of Physiology, Medical University of Bialystok, Bialystok, Poland
    J Cell Physiol 225:786-91. 2010
    ..We conclude that regulation of muscle ceramide level depends on the diet and type of skeletal muscle...
  99. ncbi Analysis of unsaponifiable compounds of edible oils by automated on-line coupling reversed-phase liquid chromatography-gas chromatography using the through oven transfer adsorption desorption interface
    Jose Manuel Cortés
    Escuela Tecnica Superior de Ingenieros Agronomos, Universidad de Castilla La Mancha, Campus Universitario s n, 02071 Albacete, Spain
    J Agric Food Chem 54:6963-8. 2006
    ..Sensitivity is more than necessary, and repeatability is good, the CV ranging from 3 to 12% for the full analysis...
  100. ncbi Comparative effect of dietary olive, safflower, and linseed oils on spontaneous liver tumorigenesis in C3H/He mice
    N T Thuy
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Japan
    J Nutr Sci Vitaminol (Tokyo) 47:363-6. 2001
    ....
  101. ncbi Trans fatty acids and cardiovascular health: translation of the evidence base
    C S Booker
    Edgar National Centre for Diabetes Research, Department of Medical and Surgical Sciences, University of Otago, PO Box 56, Dunedin, New Zealand
    Nutr Metab Cardiovasc Dis 18:448-56. 2008
    ..TFAs arise during industrial hydrogenation of vegetable or fish fats and oils and the natural digestion process in ruminant animals...

Research Grants65

  1. Fatty Acids and Cardiovascular Health
    Dariush Mozaffarian; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  2. Brain DHA, Dopamine, and Behavior: Roles in ADHD
    Beth Levant; Fiscal Year: 2006
    ..Such insights may identify a means by which certain risk factors for ADHD may be reduced or eliminated or the severity of the disease may be reduced through appropriate pre- and postnatal nutrition. [unreadable] [unreadable]..
  3. Brain LC-PUFAs and Maternal Mental Health
    Beth Levant; Fiscal Year: 2006
    ..These findings will also suggest novel treatments for such illnesses when they occur. ..
  4. NSAID Inhibition of Alzheimer Pathology: Role of DHA
    Gregory M Cole; Fiscal Year: 2010
    ..Understanding dietary fatty acid /Abeta-related PAK complex deficits and downstream synaptic defects will reveal a poorly studied overlap between cognitive deficits in mental retardation syndromes and AD with therapeutic implications. ..
  5. Psychoneuroimmunology and Mind-Body Interventions
    Janice Kiecolt Glaser; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  6. Psychoneuroimmunology and Mind-Body Medicine
    Janice Kiecolt Glaser; Fiscal Year: 2005
    ..Accordingly, a psychoneuroimmunology focus for these mechanistic studies will provide a way to clarify mechanisms while assessing clinical efficacy. ..
  7. Pregnancy Related Weight Gain: A Link to Obesity
    Anna Maria Siega Riz; Fiscal Year: 2006
    ..These data, both the quantitative and qualitative, will be used to identify modifiable behaviors for pregnant women that are associated with gaining weight above the recommended ranges and postpartum weight retention. ..
  8. Brucella, Aging and Role of IL-17 in Host Defense
    Kevin High; Fiscal Year: 2005
    ..The data generated in this proposal will form the foundation of future R01 proposals aimed at enhancing immunity vs. intracellular pathogens in our aging population. ..
  9. Modeling Antipsychotic-Induced Weight Gain in Rats
    John Fernstrom; Fiscal Year: 2005
    ..abstract_text> ..
  10. Institutional Clinical /Translational Science Awards
    John Clore; Fiscal Year: 2006
    ..Formal process and summative evaluation will ensure that planning milestones are met in preparation for submission of the U54 proposal. [unreadable] [unreadable] [unreadable]..
  11. Selenium molecular signaling in human prostate cancer
    Clement Ip; Fiscal Year: 2007
    ..Aim 4 is to study the transcriptional control of GADD153 by selenium. The proposed research is thus designed to examine systemically the impact of GADD153 induction as a result of selenium treatment. ..
  12. PHAGOCYTE RESOLVING METABOLISM
    Charles Serhan; Fiscal Year: 2009
    ..abstract_text> ..
  13. Pre-diagnostic markers of infection and risk of MS
    Alberto Ascherio; Fiscal Year: 2009
    ....
  14. ABCs of Intestinal Sterol Transport
    F Field; Fiscal Year: 2009
    ..The results of this proposal will provide new and novel information on the roles of the ABC transporters, NPC1L1, and lipid rafts in intestinal sterol metabolism ..
  15. DIETARY DEFICIENCIES AND TUBERCULOSIS VACCINE EFFICACY
    David McMurray; Fiscal Year: 2009
    ..abstract_text> ..
  16. Is S-adenosyl Methionine a Nutrition: Genetic Link in AD?
    Thomas Shea; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  17. Mechanistic Studies at the Host-pathogen Interface
    David McMurray; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  18. Organochlorine pesticide, PCBs, and Parkinsons
    Alberto Ascherio; Fiscal Year: 2007
    ..Finally, the long follow-up period will allow the investigation of long-term effects of exposure. ..
  19. Gene-Environment Interactions in Obesity and Diabetes
    Tracy Nelson; Fiscal Year: 2007
    ..Environment: Dr. Nelson will have an outstanding environment in which to carry out the proposed study, as well as, the necessary resources and support to successfully complete her training. ..
  20. SUPPRESSION OF T CELL ACTIVATION BY DIETARY FATTY ACIDS
    ROBERT CHAPKIN; Fiscal Year: 2003
    ..g., rheumatoid arthritis), without compromising host defenses. ..
  21. DIET, ENDOTHELIAL FUNCTION AND PEDIATRIC HYPERLIPIDEMIA
    Marguerite Engler; Fiscal Year: 2004
    ..Preventive nursing strategies aimed at early detection of endothelial dysfunction and dietary modification may restore endothelial function in children and adolescents at high risk for CHD. ..
  22. DIETARY FATTY CONTROL OF INFLAMMATION
    Kevin High; Fiscal Year: 2002
    ..Health relateness: Answering these fundamental questions will shed critical light on the feasibility of utilizing dietary fatty acids to regulate AA metabolism and related clinical disorders. ..
  23. DIETARY ESSENTIAL FATTY ACID ACCUMULATION IN RETINA
    JAMES BRENNA; Fiscal Year: 2002
    ..Sub-normal development will be directly revealed via functional tests to assess the impact of low omega-3 fatty acid status on develop of vision acid status on development of vision and related health parameters. ..
  24. DIET AND GENETIC RISKS FOR LUNG CANCER
    Ruth Patterson; Fiscal Year: 2002
    ..This work addresses important questions about the etiology and prevention of lung cancer, and can be completed with a modest amount of funding in addition to what has already been invested in this large chemoprevention trial. ..
  25. DIETARY ETIOLOGIES OF MULTIPLE SCLEROSIS AND PARKINSONS
    Alberto Ascherio; Fiscal Year: 2001
    ..By the end of the follow-up, we project a total of 461 confirmed cases of MS and 380 confirmed cases of PD. We will have sufficient poser to evaluate a series of specific hypotheses with substantial public health implications. ..
  26. Nanospheres as Vehicles for Treatment of Neuroblastoma
    Thomas Shea; Fiscal Year: 2004
    ..Resulting data will indicate whether or not nanospheres represent useful delivery agents for cancer therapy. ..
  27. Paclitaxel pathway transcriptional activators
    Pierre Broun; Fiscal Year: 2002
    ..The main benefits of the activator genes will be increasing Taxol supply and reducing production costs. ..
  28. LIPOPROTEIN AND ADIPOSE TISSUE METABOLISM IN HIV
    Lars Berglund; Fiscal Year: 2004
    ..abstract_text> ..
  29. CYCLOOXYGENASE-2 AND ALCOHOLIC LIVER DISEASE
    Amin Nanji; Fiscal Year: 2003
    ..The prevention and treatment of alcoholic liver injury by Cox-2 inhibitors in these experiments should provide data for the testing of these drugs in patients with alcoholic liver disease. ..
  30. POOLING OF COHORT STUDIES ON DIET & CORONARY DISEASE
    Alberto Ascherio; Fiscal Year: 2001
    ..In addition, we will ask whether nerve regeneration is altered by administration of these cytokines. This could have obvious health benefits to the millions of diabetics that suffer from nerve damage. ..
  31. Omega-6/Omega-3 Fatty Acid Ratio and Tumorigenesis
    Jing Kang; Fiscal Year: 2009
    ..Information derived from these studies will increase our understanding of the importance of n-3 fatty acids as well as n-6/n-3 fatty acid ratio in cancer prevention and help guide dietary advice. ..
  32. LCPUFA Status and Birth Outcome in India
    JAMES BRENNA; Fiscal Year: 2007
    ..Positive results would justify an intervention studies to include LCPUFA in the diets of pregnant women in developed and developing countries. ..
  33. Cysteine, Related Gene Variants and Breast Cancer Risk
    Walter C Willett; Fiscal Year: 2010
    ....
  34. Phytoestrogens, alcohol, and endometrial cancer risk
    ELISA BANDERA; Fiscal Year: 2007
    ..This award will provide the support and training the Candidate needs to develop an independent career in the nutritional epidemiology of cancer. ..
  35. Lipidomics Session ISSFAL 2006
    JAMES BRENNA; Fiscal Year: 2006
    ..ISSFAL 2006 is expected to be among the most important international lipid metabolism conferences of the year, and a lipidomics symposium is timely given the increasing progress in this area. [unreadable] [unreadable] [unreadable]..
  36. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2010
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
  37. NSAIDs, inflammation and Parkinson's disease
    Alberto Ascherio; Fiscal Year: 2009
    ..Lastly, the proposed project will establish a unique resource that will be readily available for future studies on the etiology of PD. ..
  38. Intermediate Filaments 2008 Gordon Research Conference
    Thomas Shea; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  39. WEIGHT LOSS IN OBESE BREAST CANCER SURVIVORS
    Zora Djuric; Fiscal Year: 2002
    ..This study should be useful to determine certain psychosocial are associated with extent of weight loss, and in turn whether weight loss is associated with changes in selected markers of breast cancer risk. ..
  40. Diet and Genetic Risks for Prostate Cancer
    Marian Neuhouser; Fiscal Year: 2005
    ..To date, there are 718 confirmed cases of primary prostatic carcinoma. This proposed study will provide important information about prostate cancer etiology and suggest new strategies for prevention and control. ..
  41. Functional Senescence of Innate Immunity and Pneumonia
    Kevin High; Fiscal Year: 2003
    ..These data are essential to design meaningful studies using the case-control method, the most effective means of studying the link between immune senescence and infection risk. ..
  42. Effect of Nutrition Labeling on Fast Food Choices
    Lisa Harnack; Fiscal Year: 2007
    ..This study builds on previous intervention research on point of purchase nutrition information and price incentives to provide new unique information that may have broad public health implications. [unreadable] [unreadable]..
  43. IMMUNOSUPPRESSANT MODULATION OF DRUG METABOLISM
    LANE BRUNNER; Fiscal Year: 2004
    ..This information will have direct application to transplant patients and give clinicians needed information regarding the relationship between immunosuppressive therapy and the prediction of toxicity. ..
  44. DIET, AROMATIC AMINO ACIDS, AND CNS NEUROTRANSMITTERS
    John Fernstrom; Fiscal Year: 2001
    ..Our data will also add important new information on the relative roles of TYR and PHE as substrates in CAM synthesis, and the impact of diet on CAM synthesis, acting via changes it produces in the neuronal pools of each substrate. ..
  45. Molecular biomarkers of selenium chemoprevention
    Clement Ip; Fiscal Year: 2006
    ..The goal is to broaden our understanding of the significance of clonal suppression of early transformed cells in selenium protection of cancer. ..
  46. Plasma Markers of Dietry Intervention to Delay Cognitiv*
    JAE KANG; Fiscal Year: 2005
    ..Importantly, results from the proposed grant will lay the groundwork for a future, large-scale comprehensive study to examine dietary interventions to delay cognitive function. ..
  47. CANCER PREVENTION BY SELENIUM-ENRICHED ALLIUM VEGETABLES
    Clement Ip; Fiscal Year: 2003
    ..The objective is to corroborate the significance of clonal suppression of preneoplastic lesions in selenium protection of cancer. ..
  48. DIETARY FAT REGULATION OF HEPATIC GENE EXPRESSION
    DONALD JUMP; Fiscal Year: 2009
    ..Determine how over expression of specific fatty acid elongases affects hepatic function, blood lipid composition and the onset of chronic disease. ..
  49. Monocyte / Macrophage TLR4 Expression and Signaling: A Link between Obesity and C
    Brian McFarlin; Fiscal Year: 2008
    ..The primary purpose of this investigation is to determine if obesity status alters TLR4 signaling and/or inflammatory cytokine production in blood monocyte and adipose tissue macrophage. [unreadable] [unreadable] [unreadable]..
  50. PRECISE ISOTOPE RATIO CHROMATOGRAPHY AND STABLE TRACERS
    JAMES BRENNA; Fiscal Year: 2004
    ..The successful accomplishment of these plans will yield new tools and experimental approaches for investigation of the impact of developmental factors and recent physiological history on development of chronic disease. ..
  51. Childhood obesity treatment targeting specific behaviors
    Hollie Raynor; Fiscal Year: 2007
    ..Moreover, by comparing the effects of targeting the traditional or substitute behaviors, data will be obtained for a power analysis for a full-scale trial of the effects of these two approaches on long-term weight loss. ..
  52. EFFECTS OF BUSPIRONE IN WITHDRAWAL FROM OPIATES
    Laure Buydens Branchey; Fiscal Year: 2002
    ..Buspirone has additional advantages. It is not sedating, has no withdrawal symptoms, has no abuse potential, does not potentiate central nervous system depressants and does not induce psychomotor impairment. ..
  53. RETINOIDS, M6P/IGF II RECEPTOR & CELL GROWTH REGULATION
    Jing Kang; Fiscal Year: 2002
    ..This knowledge may lead to novel or more effective therapeutic and preventive approaches for cancer and developmental defects. ..
  54. Regulation of Apolipoprotein B Secretion
    ALAN ATTIE; Fiscal Year: 2006
    ..This will enable us to differentiate between an interaction with apoB early in the secretory pathway and an interaction that occurs after apoB secretion leading to re-uptake of the lipoprotein particles. ..
  55. Impact of feeding on brain response to food stimuli in lean and obese subjects
    Marie Pierre St Onge; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  56. USE OF ANTIOXIDANT SUPPLEMENTS AND OXIDATIVE DNA DAMAGE
    Marian Neuhouser; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  57. Gas phase derivatization for lipidomic MS analysis
    JAMES BRENNA; Fiscal Year: 2007
    ....
  58. Niacin, n-3 fatty acids and insulin resistance
    William Harris; Fiscal Year: 2007
    ..This should lead to more effective therapy for the dyslipidemia of insulin resistance and ultimately to reduced risk for CHD in this burgeoning patient population. ..
  59. DIETARY INTERVENTION--WOMEN HIGH RISK FOR BREAST CANCER
    Zora Djuric; Fiscal Year: 2002
    ..The use of biomarkers will allow to evaluate the cancer-protective effects of dietary modulation over a relatively short period of time. ..
  60. Postprandial glycemic response to 4-week low and high glycemic load diets
    Marian Neuhouser; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  61. 2003 Kern Aspen Lipid Conference: Integrative Mechanisms
    Lawrence Rudel; Fiscal Year: 2003
    ..The timeliness of this meeting is viewed as a strength. ..
  62. Cholesterol and fatty acids in cocaine addiction relapse
    Laure Buydens Branchey; Fiscal Year: 2004
    ..If our preliminary findings are confirmed, the use of fatty acids supplements or changes in dietary habits could have a significant potential in the prevention of relapse in a subgroup of cocaine addicts. ..
  63. DIETARY OBESITY
    George Bray; Fiscal Year: 2007
    ..We now propose these well founded, important and exciting studies which will provide critical new insights into anatomical, physiological and molecular mechanisms by which high levels of dietary fat induce obesity. ..