zinc compounds

Summary

Summary: Inorganic compounds that contain zinc as an integral part of the molecule.

Top Publications

  1. doi The cytotoxicity of cadmium based, aqueous phase - synthesized, quantum dots and its modulation by surface coating
    Yuanyuan Su
    Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Jialuo Road 2019, Shanghai 201800, China
    Biomaterials 30:19-25. 2009
  2. doi Chemiluminescent and chemiluminescence resonance energy transfer (CRET) detection of DNA, metal ions, and aptamer-substrate complexes using hemin/G-quadruplexes and CdSe/ZnS quantum dots
    Ronit Freeman
    Institute of Chemistry, Center of Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Am Chem Soc 133:11597-604. 2011
  3. doi Synthesis of CdTe/CdS/ZnS quantum dots and their application in imaging of hepatocellular carcinoma cells and immunoassay for alpha fetoprotein
    Jianniao Tian
    Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources Ministry of Education of China, College of Chemistry and Chemical Engineering of Guangxi Normal University, Guilin, People s Republic of China
    Nanotechnology 21:305101. 2010
  4. pmc In vitro toxicity assessment of amphiphillic polymer-coated CdSe/ZnS quantum dots in two human liver cell models
    Wesley E Smith
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, United States
    ACS Nano 6:9475-84. 2012
  5. doi Characterization and stability analysis of zinc oxide nanoencapsulated conjugated linoleic acid
    Jin Ho Choy
    Dept of Chemistry, Ewha Womans Univ, Seoul, Korea
    J Food Sci 75:N63-8. 2010
  6. pmc Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes
    A Mahmood
    Department of Gastroenterology, Imperial College London, UK
    Gut 56:168-75. 2007
  7. ncbi Fluorescence resonance energy transfer between quantum dot donors and dye-labeled protein acceptors
    Aaron R Clapp
    Optical Sciences Division, Code 5611, U S Naval Research Laboratory, Washington, D C 20375, USA
    J Am Chem Soc 126:301-10. 2004
  8. ncbi Cell-penetrating quantum dots based on multivalent and endosome-disrupting surface coatings
    Hongwei Duan
    Department of Biomedical Engineering, Emory University, Atlanta, Georgia, USA
    J Am Chem Soc 129:3333-8. 2007
  9. doi Zinc differentially acts on components of long-term potentiation at hippocampal CA1 synapses
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Brain Res 1323:59-64. 2010
  10. ncbi Zinc phosphate as versatile material for potential biomedical applications Part II
    L Herschke
    Max Planck Institute for Polymer Research, Ackermannweg 10, D 55128, Mainz, Germany
    J Mater Sci Mater Med 17:95-104. 2006

Detail Information

Publications191 found, 100 shown here

  1. doi The cytotoxicity of cadmium based, aqueous phase - synthesized, quantum dots and its modulation by surface coating
    Yuanyuan Su
    Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Jialuo Road 2019, Shanghai 201800, China
    Biomaterials 30:19-25. 2009
    ....
  2. doi Chemiluminescent and chemiluminescence resonance energy transfer (CRET) detection of DNA, metal ions, and aptamer-substrate complexes using hemin/G-quadruplexes and CdSe/ZnS quantum dots
    Ronit Freeman
    Institute of Chemistry, Center of Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Am Chem Soc 133:11597-604. 2011
    ..By the application of three different sized QDs functionalized with different hairpins, the multiplexed analysis of three different DNA targets is demonstrated by the generation of three different CRET luminescence signals...
  3. doi Synthesis of CdTe/CdS/ZnS quantum dots and their application in imaging of hepatocellular carcinoma cells and immunoassay for alpha fetoprotein
    Jianniao Tian
    Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources Ministry of Education of China, College of Chemistry and Chemical Engineering of Guangxi Normal University, Guilin, People s Republic of China
    Nanotechnology 21:305101. 2010
    ....
  4. pmc In vitro toxicity assessment of amphiphillic polymer-coated CdSe/ZnS quantum dots in two human liver cell models
    Wesley E Smith
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, United States
    ACS Nano 6:9475-84. 2012
    ..Thus, further in vivo studies are warranted to ensure that TOPO-PMAT-coated Qdots used in biomedical applications do not induce inflammatory responses as a consequence of hepatic uptake...
  5. doi Characterization and stability analysis of zinc oxide nanoencapsulated conjugated linoleic acid
    Jin Ho Choy
    Dept of Chemistry, Ewha Womans Univ, Seoul, Korea
    J Food Sci 75:N63-8. 2010
    ..Nanoencapsulation improved the thermal stability of CLA by about 25%, compared to pristine CLA. Practical Application: This system can be used for protection of encapsulated negatively-charged food ingredients from thermal processing...
  6. pmc Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes
    A Mahmood
    Department of Gastroenterology, Imperial College London, UK
    Gut 56:168-75. 2007
    ..Zinc carnosine (ZnC) is a health food product claimed to possess health-promoting and gastrointestinal supportive activity. Scientific evidence underlying these claims is, however, limited...
  7. ncbi Fluorescence resonance energy transfer between quantum dot donors and dye-labeled protein acceptors
    Aaron R Clapp
    Optical Sciences Division, Code 5611, U S Naval Research Laboratory, Washington, D C 20375, USA
    J Am Chem Soc 126:301-10. 2004
    ....
  8. ncbi Cell-penetrating quantum dots based on multivalent and endosome-disrupting surface coatings
    Hongwei Duan
    Department of Biomedical Engineering, Emory University, Atlanta, Georgia, USA
    J Am Chem Soc 129:3333-8. 2007
    ..These insights are important toward the design and development of nanoparticle agents for intracellular imaging and therapeutic applications...
  9. doi Zinc differentially acts on components of long-term potentiation at hippocampal CA1 synapses
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Brain Res 1323:59-64. 2010
    ..The present study suggests that zinc differentially acts on CA1 LTP components...
  10. ncbi Zinc phosphate as versatile material for potential biomedical applications Part II
    L Herschke
    Max Planck Institute for Polymer Research, Ackermannweg 10, D 55128, Mainz, Germany
    J Mater Sci Mater Med 17:95-104. 2006
    ..In-situ monitoring of the transformation of Brushite in Hydroxyapatite is also reported...
  11. ncbi microPET-based biodistribution of quantum dots in living mice
    Meike L Schipper
    Departments of Radiology and Bioengineering, Bio X Program, Molecular Imaging Program at Stanford MIPS, Stanford University, East 150 Clark Center, Palo Alto, CA 94305, USA
    J Nucl Med 48:1511-8. 2007
    ..This study evaluates the quantitative biodistribution of commercially available CdSe quantum dots (QD) in mice...
  12. ncbi Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles
    Christian Kirchner
    Center for Nanoscience, Ludwig Maximilians Universitat Munchen, Germany
    Nano Lett 5:331-8. 2005
    ..Additional patch clamp experiments investigate effects of the particles on currents through ion channels...
  13. doi CdSe/ZnS quantum dots-G-quadruplex/hemin hybrids as optical DNA sensors and aptasensors
    Etery Sharon
    Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Anal Chem 82:7073-7. 2010
    ..This phenomenon is implemented to develop DNA sensors or aptasensors by tailoring hairpin-functionalized QDs that generate the hemin/G-quadruplex quenchers upon sensing of the respective analytes...
  14. doi Reactive oxygen species-quenching and anti-apoptotic effect of polaprezinc on indomethacin-induced small intestinal epithelial cell injury
    Tatsushi Omatsu
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto, 602 8566, Japan
    J Gastroenterol 45:692-702. 2010
    ..In addition, the protective role of PZ and the possible mechanism of its effect on indomethacin-induced small intestinal injury were investigated...
  15. ncbi Acid secretion and proton conductance in human airway epithelium
    Horst Fischer
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Am J Physiol Cell Physiol 282:C736-43. 2002
    ..2 +/- 3.8 pS/pF (at 0 mV and a pH 5.3-to-pH 7.3 gradient). We suggest that inflammatory processes activate proton secretion by the airway epithelium and acidify the airway surface liquid...
  16. doi Differential effects of zinc influx via AMPA/kainate receptor activation on subsequent induction of hippocampal CA1 LTP components
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE 21, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Brain Res 1354:188-95. 2010
    ..Zinc influx via AMPA/kainate receptor activation may differentially act on subsequent induction of CA1 LTP components...
  17. ncbi Inhibitory effect of polaprezinc on the inflammatory response to Helicobacter pylori
    Osamu Handa
    Department of Intrernal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Can J Gastroenterol 16:785-9. 2002
    ..These results suggest that polaprezinc, mainly the zinc component, may inhibit H pylori-induced PMN-mediated gastric inflammation by attenuating CD11b/CD18 expression on PMN and IL-8 production from gastric epithelial cells...
  18. ncbi Enhanced fluorescence intermittency of CdSe-ZnS quantum-dot clusters
    Ming Yu
    Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA
    Phys Rev Lett 97:237402. 2006
    ..The nature of this coupling is not known, though electrons trapped from QDs when they blink off may play a role by altering the electronic environment of neighboring QDs and enhancing their fluorescence properties...
  19. doi Fluorescence enhancement effect of morin-nucleic acid-L-cysteine-capped nano-ZnS system and the determination of nucleic acid
    Liangliang Zhao
    A Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, Shandong, PR China
    Analyst 133:896-902. 2008
    ....
  20. ncbi Solubilization of insoluble zinc compounds by Gluconacetobacter diazotrophicus and the detrimental action of zinc ion (Zn2+) and zinc chelates on root knot nematode Meloidogyne incognita
    V S Saravanan
    School of Bio Engineering and Bio Sciences, Vellore Institute of Technology VIT, Vellore, Tamil Nadu, India
    Lett Appl Microbiol 44:235-41. 2007
    ..The presence of Zn compounds in the culture filtrates of G. diazotrophicus enhanced the mortality and reduced the root penetration of M. incognita under in vitro conditions...
  21. pmc Proton secretion in freshly excised sinonasal mucosa from asthma and sinusitis patients
    Do Yeon Cho
    Division of Rhinology, Department of Otolaryngology Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, USA
    Am J Rhinol Allergy 23:e10-3. 2009
    ..The objective of this study was to determine H+ secretion in asthmatic and nonasthmatic patients with chronic rhinosinusitis (CRS) in freshly excised human sinonasal tissue...
  22. ncbi The European Union risk assessment on zinc and zinc compounds: the process and the facts
    Charles W M Bodar
    National Institute for Public Health and the Environment RIVM, Expert Centre for Substances SEC, The Netherlands
    Integr Environ Assess Manag 1:301-19. 2005
    ..process of drawing conclusions of the risk assessment are outlined: potential environmental risks of zinc and zinc compounds may occur at local and regional scales in surfacewater, sediment, and soil...
  23. pmc Rotational and translational diffusion of peptide-coated CdSe/CdS/ZnS nanorods studied by fluorescence correlation spectroscopy
    James M Tsay
    Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Am Chem Soc 128:1639-47. 2006
    ..Monitoring rotational diffusion of bioconjugated NRs using FCS might prove to be useful for observing binding and conformational dynamics in biological systems...
  24. ncbi Continuous distribution of emission states from single CdSe/ZnS quantum dots
    Kai Zhang
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Nano Lett 6:843-7. 2006
    ..These results were consistent with the model that charged quantum dots were also emissive, and that time-dependent charge migration gave rise to the observed photoluminescence dynamics...
  25. pmc On the origin of life in the zinc world. 2. Validation of the hypothesis on the photosynthesizing zinc sulfide edifices as cradles of life on Earth
    Armen Y Mulkidjanian
    School of Physics, Universitat Osnabruck, D 49069 Osnabruck, Germany
    Biol Direct 4:27. 2009
    ..The hypothesis suggests that life emerged within compartmentalized, photosynthesizing ZnS formations of hydrothermal origin (the Zn world), assembled in sub-aerial settings on the surface of the primeval Earth...
  26. pmc On the origin of life in the zinc world: 1. Photosynthesizing, porous edifices built of hydrothermally precipitated zinc sulfide as cradles of life on Earth
    Armen Y Mulkidjanian
    School of Physics, Universitat Osnabruck, D 49069 Osnabruck, Germany
    Biol Direct 4:26. 2009
    ..Their number, however, can be dramatically reduced by the simultaneous consideration of various bioenergetic, physical, and geological constraints...
  27. ncbi NADPH oxidase-dependent acid production in airway epithelial cells
    Christian Schwarzer
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    J Biol Chem 279:36454-61. 2004
    ..These data suggest a role for an apically located Duox-based NADPH oxidase during intracellular H(+) production and H(+) secretion, but not in H(+) conduction...
  28. ncbi How to hide zinc in a small protein
    Claudia A Blindauer
    School of Chemistry, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, UK
    Acc Chem Res 38:62-9. 2005
    ..Clearly, proteins can exert fine control over both the thermodynamics and kinetics of zinc binding in thiolate clusters. Genome sequences suggest that related zinc-finger sites are common in a variety of bacteria...
  29. ncbi On the generation of free radical species from quantum dots
    Binil Itty Ipe
    Biologisch Chemische Mikrostrukturtechnik, Fachbereich Chemie, Universitat Dortmund, Otto Hahn Str 6, 44227, Dortmund, Germany
    Small 1:706-9. 2005
  30. ncbi Quantum dot photon statistics measured by three-dimensional particle tracking
    Kevin McHale
    Physical Measurement and Control 266 33, California Institute of Technology, Pasadena, California 91125, USA
    Nano Lett 7:3535-9. 2007
    ..In addition, we show that 2-mercaptoethanol suppresses short time-scale intermittency (1 ms to 1 s) in quantum dot fluorescence by reducing time spent in the off-state...
  31. ncbi Protection by polaprezinc against radiation-induced apoptosis in rat jejunal crypt cells
    Mutsumi Matsuu-Matsuyama
    Division of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoro, Nagasaki, Japan
    J Radiat Res 49:341-7. 2008
    ..Polaprezinc treatment resulted in decreases of p53 accumulation, p21(WAF1/CIP1) and Bax expression after irradiation. Polaprezinc has a protective effect against ionizing radiation induced apoptosis in rat jejunal crypt cells...
  32. ncbi Ordering of quantum dots using genetically engineered viruses
    Seung Wuk Lee
    Department of Chemistry and Biochemistry, Center for Nano and Molecular Science and Technology, Texas Materials Institute, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Science 296:892-5. 2002
    ..In addition, suspensions were prepared in which the lyotropic liquid crystalline phase behavior of the hybrid material was controlled by solvent concentration and by the use of a magnetic field...
  33. ncbi Regulation of human eosinophil NADPH oxidase activity: a central role for PKCdelta
    J L Bankers-Fulbright
    Allergic Diseases Research Laboratory, Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Cell Physiol 189:306-15. 2001
    ..Our results indicate that the G-protein-coupled LTB4 receptor and the IL-5 cytokine receptor converge on a common signaling pathway involving PI 3-kinase and PKCdelta to regulate NADPH oxidase activity in human eosinophils...
  34. ncbi Bionanofabrication of metallic and semiconductor nanoparticle arrays using S-layer protein lattices with different lateral spacings and geometries
    Sonny S Mark
    Department of Microbiology, Cornell University, Ithaca, New York 14853, USA
    Langmuir 22:3763-74. 2006
    ..These results demonstrate that it is possible to exploit the physicochemical/structural diversity of prokaryotic S-layer scaffolds to vary the morphological patterning of nanoscale metallic and semiconductor NP arrays...
  35. ncbi In-situ encapsulation of quantum dots into polymer microspheres
    Wenchao Sheng
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
    Langmuir 22:3782-90. 2006
    ....
  36. ncbi Highly luminescent Cd1-xZnxSe/ZnS core/shell nanocrystals emitting in the blue-green spectral range
    Myriam Protière
    DSM DRFMC SPrAM UMR 5819 CEA CNRS Université Joseph Fourier 1 LEMOH, CEA Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France
    Small 3:399-403. 2007
  37. ncbi Labeling and intracellular tracking of functionally active plasmid DNA with semiconductor quantum dots
    Charudharshini Srinivasan
    Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Road, Unit 3092, Storrs, 06269, USA
    Mol Ther 14:192-201. 2006
    ..62%, which was comparable to the control (unconjugated) plasmid DNA...
  38. pmc Binding of muscimol-conjugated quantum dots to GABAC receptors
    Hélène A Gussin
    Lions of Illinois Eye Research Institute, Department of Ophthalmology and Visual Sciences, and Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Am Chem Soc 128:15701-13. 2006
    ....
  39. ncbi Luminescent quantum dots fluorescence resonance energy transfer-based probes for enzymatic activity and enzyme inhibitors
    Lifang Shi
    Department of Chemistry and the Advanced Material Research Institute, University of New Orleans, New Orleans, Louisiana 70148, USA
    Anal Chem 79:208-14. 2007
    ..The quantum dot FRET-based probes were used to monitor the enzymatic activity of trypsin and to screen trypsin inhibitors for their inhibition efficiency...
  40. ncbi Metallothioneins initiate semiconducting nanoparticle cellular toxicity
    Baikuntha P Aryal
    Department of Chemistry, Wayne State University, Detroit, MI 48202, USA
    Small 2:1159-63. 2006
  41. ncbi Surface-plasmon-coupled emission of quantum dots
    Ignacy Gryczynski
    Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Phys Chem B 109:1088-93. 2005
    ....
  42. ncbi Probing biocatalytic transformations with CdSe-ZnS QDs
    Ron Gill
    Institute of Chemistry and the Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Am Chem Soc 128:15376-7. 2006
    ..The luminescence of QDs modified by the enzyme-generated quinone units is quenched. The quinone-functionalized peptide associated with the QDs was cleaved by thrombin, a process that restored the luminescence of the QDs...
  43. ncbi Fluorescent nanocrystals as colloidal probes in complex fluids measured by fluorescence correlation spectroscopy
    Tim Liedl
    LMU Munchen, Department für Physik, Amalienstrasse 54, 80799 Munchen, Germany
    Small 1:997-1003. 2005
    ..The decreasing diffusion coefficient of the nanocrystals with increasing actin concentration results in an intrinsic polymer viscosity of 0.12+/-0.02 ml mg(-1), in accordance with literature values...
  44. ncbi A feasible and quantitative encoding method for microbeads with multicolor quantum dots
    Hai Qiao Wang
    Key Laboratory of Biomedical Photonics of Ministry of Education Hubei Bioinformatics and Molecular Imaging Key Laboratory, Huazhong University of Science and Technology, Wuhan, Hubei, 430074 PR China
    J Fluoresc 17:133-8. 2007
    ..It suggests that the encoded beads from this method have the practicability in biological applications and chemical analysis...
  45. doi Synthesis of carbohydrate-conjugated nanoparticles and quantum dots
    Christopher Earhart
    Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore
    Langmuir 24:6215-9. 2008
    ..Silica-coated nanoparticles of Ag, Fe3O4, and ZnS-CdSe were synthesized and functionalized with dextran. The resulting 10-40-nm-sized particles were robust, water-soluble, colloidally stable, and biochemically active...
  46. doi Effect of ligand density on the spectral, physical, and biological characteristics of CdSe/ZnS quantum dots
    Samuel J Clarke
    Department of Biomedical Engineering, McGill University, Montreal, QC Canada H3A 2B4
    Bioconjug Chem 19:562-8. 2008
    ..These results will enable users to develop methods for screening QD conjugates for biological activity before proceeding to experiments with cell lines and animals...
  47. ncbi Dual sensing of oxygen and temperature using quantum dots and a ruthenium complex
    P A S Jorge
    Unidade de Optoelectrónica e Sistemas Electrónicos, INESC Porto, Rua do Campo Alegre, 687, 4169 007 Porto, Portugal
    Anal Chim Acta 606:223-9. 2008
    ..In particular, it was shown that a 10% error in the measured oxygen concentration, induced by a change in the sample temperature, could be compensated using the nanocrystals temperature information and a correction function...
  48. doi Optical detection of glucose and acetylcholine esterase inhibitors by H2O2-sensitive CdSe/ZnS quantum dots
    Ron Gill
    Institute of Chemistry and Center for Nanoscience, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Angew Chem Int Ed Engl 47:1676-9. 2008
  49. doi Fluorescent II-VI semiconductor quantum dots in living cells: nonlinear microspectroscopy in an optical tweezers system
    Patricia M A Farias
    Departamento de Biofisica e Radiobiologia, UFPE, Recife, PE, Brazil, Departamento de Ciencias Farmaceuticas, UFPE, Recife, PE, Brazil
    J Phys Chem B 112:2734-7. 2008
    ....
  50. doi Simple and accurate quantification of quantum dots via single-particle counting
    Chun Yang Zhang
    Department of Chemistry, York College and The Graduate Center, The City University of New York, Jamaica, New York 11451, USA
    J Am Chem Soc 130:3750-1. 2008
    ....
  51. ncbi Preparation and characterization of thiacalix[4]arene coated water-soluble CdSe/ZnS quantum dots as a fluorescent probe for Cu2+ ions
    Takashi Jin
    Research Institute for Electronic Science, Hokkaido University, Sapporo 060 0812, Japan
    Comb Chem High Throughput Screen 10:473-9. 2007
    ..A possible quenching mechanism by Cu2+ ions was also discussed on the basis of a Langmuir-type adsorption isotherm...
  52. doi Minimizing nonspecific cellular binding of quantum dots with hydroxyl-derivatized surface coatings
    Brad A Kairdolf
    Department of Biomedical Engineering, Emory University, 101 Woodruff Circle, Suite 2001, Atlanta, Georgia 30322, USA
    Anal Chem 80:3029-34. 2008
    ....
  53. ncbi Hybrid white-light emitting-LED based on luminescent polyfluorene polymer and quantum dots
    Cheng Hsuan Chou
    Phosphors Research Laboratory, Department of Applied Chemistry and UST CNST, National Chiao Tung University, Hsinchu 30050, Taiwan
    J Nanosci Nanotechnol 7:2785-9. 2007
    ..The EL spectra at different driving voltages, I-V characteristics, and EL chromaticity of the LEDs based on PF1/QD and PFO/QD LEDs have been measured, investigated, and compared, respectively...
  54. ncbi A highly luminescent ZnS/CdSe/ZnS nanocrystals-tetrapeptide biolabeling agent
    Yang Li
    The Manchester Materials Science Centre, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK
    J Nanosci Nanotechnol 7:2301-8. 2007
    ..The labeling of cells was demonstrated by confocal microscopy. Hybrid bio-inorganic nanoconjugates are potentially powerful fluorescent tracking tools in biological systems...
  55. ncbi Synthesis of ZnSe quantum dots and ZnSe-ZnS core/shell nanostructures
    Moazzam Ali
    Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore 560012, India
    J Nanosci Nanotechnol 7:1960-4. 2007
    ..We also synthesized the reverse type core/shell ZnS/ZnSe nanocrystals. These exhibited a significant red shift in the absorption edge after coating with a thin ZnSe shell...
  56. ncbi Growth of semiconducting nanocrystals of CdS and ZnS
    Ranjani Viswanatha
    Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore 560012, India
    J Nanosci Nanotechnol 7:1726-9. 2007
    ..Further, the self-focusing of the size distribution can be observed and is more pronounced at higher temperatures reducing its relative width from 25% to 10%...
  57. ncbi Multi-color encoding of polystyrene microbeads with CdSe/ZnS quantum dots and its application in immunoassay
    Hai Qiao Wang
    Key Laboratory of Biomedical Photonics of Ministry of Education Wuhan National Laboratory for Optoelectronics, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, PR China
    J Colloid Interface Sci 316:622-7. 2007
    ..The result indicates that the encoded beads can detect the antibody signal effectively. And the effective detection range of the antibody is about 2-15 microM...
  58. ncbi Characterization of quantum dots using capillary zone electrophoresis
    Mark Pereira
    Department of Chemistry, Ottawa Carleton Chemistry Institute, Carleton University, Ottawa, ON, Canada
    Electrophoresis 28:2874-81. 2007
    ..This preliminary knowledge will serve as a basis for new CE immunoassay studies of QD-biomolecule conjugates and their immunocomplexes with target analytes...
  59. doi Multidentate surface ligand exchange for the immobilization of CdSe/ZnS quantum dots and surface quantum dot-oligonucleotide conjugates
    W Russ Algar
    Department of Chemical and Physical Sciences, University of Toronto, Mississauga ON L5L 1C6, Canada
    Langmuir 24:5514-20. 2008
    ..This versatile immobilization chemistry is an important step in the development of surface-based QD nanosensors. Such technology requires QDs to be immobilized such that they remain accessible to target molecules in solution...
  60. doi Conformation, thermodynamics and stoichiometry of HSA adsorbed to colloidal CdSe/ZnS quantum dots
    Qi Xiao
    State Key Laboratory of Virology, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China
    Biochim Biophys Acta 1784:1020-7. 2008
    ..The results suggested that HSA underwent substantial conformational changes at both secondary and tertiary structure levels. The stoichiometry of HSA attached to QDs was obtained by dynamic light scattering (DLS) and zeta-potential...
  61. ncbi Nanocrystal-based luminescent composites for nanoimprinting lithography
    Michela Tamborra
    Chemistry Department, University of Bari, Bari, Italy
    Small 3:822-8. 2007
  62. ncbi Substrate- and time-dependent photoluminescence of quantum dots inside the ultrathin polymer LbL film
    Dmitry Zimnitsky
    School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Langmuir 23:4509-15. 2007
    ....
  63. doi Flow cytometric analysis to detect pathogens in bacterial cell mixtures using semiconductor quantum dots
    Megan A Hahn
    Department of Chemistry, University of Rochester, Rochester, New York 14627, USA
    Anal Chem 80:864-72. 2008
    ....
  64. ncbi [A new fluorescent marker for in vivo imaging]
    Benoit Dubertret
    Med Sci (Paris) 19:532-4. 2003
  65. ncbi Quantum-dot-based cell motility assay
    Weiwei Gu
    Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Sci STKE 2005:pl5. 2005
    ....
  66. doi Use of CdSe/ZnS luminescent quantum dots incorporated within sol-gel matrix for urea detection
    Hong Dinh Duong
    School of Applied Chemical Engineering, Research Center for Biophotonics, Chonnam National University, Yong Bong dong 300, 500 757 Gwangju, Republic of Korea
    Anal Chim Acta 626:53-61. 2008
    ..The good stability of the three sol-gel membranes for urea sensing over 2 months showed that the use of sol-gel membranes immobilized with QDs or an enzyme is suitable for biomedical and environmental applications...
  67. doi Semiconductor quantum dots and metal nanoparticles: syntheses, optical properties, and biological applications
    Vasudevanpillai Biju
    Nano Bioanalysis Team, Health Technology Research Center, National Institute of Advanced Industrial Science and Technology AIST, 2217 14 Hayashi Cho, Takamatsu, Kagawa, 761 0395, Japan
    Anal Bioanal Chem 391:2469-95. 2008
    ..Other aspects of the review are in vivo deep tissue imaging, multiphoton excitation, NIR fluorescence and SERS imaging, and toxic effects of NPs and their clearance from the body...
  68. ncbi Synthesis of compact multidentate ligands to prepare stable hydrophilic quantum dot fluorophores
    H Tetsuo Uyeda
    US Naval Research Laboratory, Division of Optical Sciences, Center for Bio Molecular Science and Engineering, Washington, DC 20375, USA
    J Am Chem Soc 127:3870-8. 2005
    ..These ligands provide a straightforward means of preparing QDs that exhibit greater resistance to environmental changes, making them more amenable for use in live cell imaging and other biotechnological applications...
  69. ncbi Semiconductor quantum dots as biological imaging agents
    Mark Green
    Department of Physics, King s College London, The Strand, London WC2R 2LS, UK
    Angew Chem Int Ed Engl 43:4129-31. 2004
  70. doi Stability and fluorescence quantum yield of CdSe-ZnS quantum dots--influence of the thickness of the ZnS shell
    Markus Grabolle
    Federal Institute for Materials Research and Testing, Department I 5, Richard Willstaetter Str 11, 12489 Berlin, Germany
    Ann N Y Acad Sci 1130:235-41. 2008
    ..The quantum yield increases from less than 5% for unshelled CdSe up to 50%, with an increase in ZnS shell thickness up to 0.6-0.8 nm. At the same time, the particles become significantly more stable, as revealed by the shell test...
  71. doi Quantum dot fluorescence as a function of alkyl chain length in aqueous environments
    Amy Szuchmacher Blum
    Naval Research Laboratory, 4555 Overlook Avenue SW, Washington, D C 20375, USA
    Langmuir 24:9194-7. 2008
    ..Our results show that the quantum yield of CdSe/ZnS quantum dots is highest for the longest alkyl chain length, suggesting that a more hydrophobic environment is beneficial for generating bright, water-soluble quantum dots...
  72. ncbi Synthesis and photoluminescence study of molecularly imprinted polymers appended onto CdSe/ZnS core-shells
    Chin I Lin
    Union Chemical Laboratories, Department of Polymer Technology, Industrial Technology Research Institute, 321 Kuang Fu Road, Section 2, Hsinchu 300, Taiwan, ROC
    Biosens Bioelectron 20:127-31. 2004
    ..The intensity of photoluminescence emission is detected upon analyte binding...
  73. ncbi Near-complete suppression of quantum dot blinking in ambient conditions
    Sungchul Hohng
    Physics Department, University of Illinois, Urbana Champaign, Urbana, Illinois 61801, USA
    J Am Chem Soc 126:1324-5. 2004
    ..Blinking can also reduce the brightness in ensemble imaging via signal saturation. Here we show that the quantum dot blinking can be suppressed with the emission duty cycle approaching 100% while maintaining biocompatibility...
  74. ncbi Layer-by-layer growth of CdSe-based nanocrystal light-emitting diodes
    J Lee
    Nanomaterials Optoelectronics Laboratory, University of Connecticut, Storrs, Connecticut 06269, USA
    J Nanosci Nanotechnol 1:59-64. 2001
    ..Using this technique, high-quality luminescent films of these nanocrystals can be built with well-defined thicknesses. Electroluminescent devices have been fabricated using this methodology...
  75. ncbi A Raman study of CdSe and ZnSe nanostructures
    Pallavi V Teredesai
    Department of Physics, Indian Institute of Science, Bangalore 560 012, India
    J Nanosci Nanotechnol 2:495-8. 2002
    ..The mode at 237 cm-1 is the surface phonon...
  76. ncbi Water-soluble quantum dots for multiphoton fluorescence imaging in vivo
    Daniel R Larson
    School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    Science 300:1434-6. 2003
    ..We visualized quantum dots dynamically through the skin of living mice, in capillaries hundreds of micrometers deep. We found no evidence of blinking (fluorescence intermittency) in solution on nanosecond to millisecond time scales...
  77. ncbi Preparation and characterization of overcoated II-VI quantum dots
    Hai Yan Xie
    College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P R China
    J Nanosci Nanotechnol 5:880-6. 2005
    ..They are likely to be used further for biological labels...
  78. ncbi Stability and quantum yield effects of small molecule additives on solutions of semiconductor nanoparticles
    Joseph A Gaunt
    Department of Chemistry, University of York, Heslington, York YO10 5DD, UK
    J Colloid Interface Sci 290:437-43. 2005
    ..Antioxidant was shown to be effective at reducing the rate of photooxidative degradation for all particles in chloroform but not in toluene...
  79. pmc Enhancing the photoluminescence of peptide-coated nanocrystals with shell composition and UV irradiation
    James M Tsay
    Department of Chemistry and Biochemistry, and Department of Physiology, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Phys Chem B 109:1669-74. 2005
    ....
  80. ncbi A facile method for coding and labeling assays on polystyrene beads with differently colored luminescent nanocrystals
    J Riegler
    Freiburg Materials Research Center FMF, Stefan Meier Strasse 21, 79104, Freiburg, Germany
    Anal Bioanal Chem 384:645-50. 2006
    ..The beads were subsequently used on a model streptavidin-biotin binding system in order to demonstrate the applicability of the technique to enzyme-linked assays and multiplexing applications...
  81. ncbi Quantum dots as efficient energy acceptors in a time-resolved fluoroimmunoassay
    Niko Hildebrandt
    Physikalische Chemie, Institut für Chemie und Interdisziplinäres Zentrum für Photonik, Universitat Potsdam, Karl Liebknecht Strasse 24 25, 14476 Potsdam Golm, Germany
    Angew Chem Int Ed Engl 44:7612-5. 2005
  82. ncbi Intracellular uptake of CdSe-ZnS/polystyrene nanobeads
    Yong Zhang
    Division of Bioengineering, Faculty of Engineering, National University of Singapore, Singapore 117576
    J Biomed Mater Res B Appl Biomater 76:161-8. 2006
    ..The longevity of QDs allows the intracellular delivery of the nanobeads to be tracked over a certain time period...
  83. ncbi Synthesis of quantum dot-tagged submicrometer polystyrene particles by miniemulsion polymerization
    Nancy Joumaa
    UMR 2714 CNRS bioMérieux Systèmes Macromoléculaires et Physiopathologie Humaine ENS Lyon 46, allée d Italie 69364 Lyon Cedex 07, France
    Langmuir 22:1810-6. 2006
    ..QD-tagged particles displayed higher fluorescence intensity with TOPO-coated QDs compared to those with the vinyl moiety. The obtained fluorescent particles open up new opportunities for a variety of applications in biotechnology...
  84. ncbi The internalized CdSe/ZnS quantum dots impair the chondrogenesis of bone marrow mesenchymal stem cells
    Shu Chen Hsieh
    Institute of Biomedical Engineering, National Yang Ming University, Shih Pai, Taipei, Taiwan, Republic of China
    J Biomed Mater Res B Appl Biomater 79:95-101. 2006
    ..Our results that the presence of QDs interferes with the chondrogenic differentiation of MSCs raise concerns in using the QDs as fluorescence tracers for stem cells...
  85. ncbi The inhibition of osteogenesis with human bone marrow mesenchymal stem cells by CdSe/ZnS quantum dot labels
    Shu Chen Hsieh
    Institute of Biomedical Engineering, National Yang Ming University, Taipei 112, Taiwan
    Biomaterials 27:1656-64. 2006
    ..Together our results show that the presence of QDs in hBMSCs prevents the full response of the cells to induced osteogenic differentiation...
  86. doi Examination of the stability of hydrophobic (CdSe)ZnS quantum dots in the digestive tract of rats
    Vitalijus Karabanovas
    Vilnius University Laser Research Center, Sauletekio 9 c3, LT 10222, Vilnius, Lithuania
    Photochem Photobiol Sci 7:725-9. 2008
    ..Quantum dots mixed with fat were more stable and degraded more slowly than quantum dots sonificated in water. The data obtained suggest possible toxicity of (CdSe)ZnS quantum dots due to the liberation of Cd(2+)...
  87. ncbi Creating optical anisotropy of CdSe/ZnS quantum dots by coupling to surface plasmon polariton resonance of a metal grating
    H K Fu
    Department of Physics, National Taiwan University, Taipei 106, Taiwan, Republic of China
    Opt Express 16:6361-7. 2008
    ..Due to the importance of quantum dots in optoelectronic devices, our new approach should be useful for future application...
  88. ncbi Three-photon absorption in semiconductor quantum dots: experiment
    Xiaobo Feng
    Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore
    Opt Express 16:6999-7005. 2008
    ..The discrepancy is also found for smaller QDs (dot-radius is less than one-third of the exciton Bohr radius), which is attributed to neglecting the mixing among the three valence bands in the theory...
  89. ncbi Zinc bioavailability is improved by the micronised dispersion of zinc oxide with the addition of L-histidine in zinc-deficient rats
    Kengo Ishihara
    Department of Human Nutrition, School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan
    J Nutr Sci Vitaminol (Tokyo) 54:54-60. 2008
    ..Water-soluble zinc compounds, such as zinc sulfate or zinc citrate, are better absorbed but have an unacceptable taste...
  90. ncbi Zinc absorption from zinc oxide, zinc sulfate, zinc oxide + EDTA, or sodium-zinc EDTA does not differ when added as fortificants to maize tortillas
    Christine Hotz
    Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
    J Nutr 135:1102-5. 2005
    ..However, little is known about the relative bioavailability of different zinc compounds that may be used in food fortification...
  91. doi Zinc lozenges as cure for the common cold--a review and hypothesis
    George A Eby
    Director of Research, George Eby Research Institute, 14909 C Fitzhugh Road, Austin, TX 78736, USA
    Med Hypotheses 74:482-92. 2010
    ..between trials, with zinc acetate (ZA) releasing 100% iZn, zinc gluconate (ZG) releasing 72% iZn and other zinc compounds releasing much less or none at physiologic pH 7.4...
  92. ncbi Zinc
    D G Barceloux
    J Toxicol Clin Toxicol 37:279-92. 1999
    ..The ingestion of 1-2 g zinc sulfate produces emesis. Zinc compounds can produce irritation and corrosion of the gastrointestinal tract, along with acute renal tubular necrosis ..
  93. doi Toxicity of ZnO and CuO nanoparticles to ciliated protozoa Tetrahymena thermophila
    Monika Mortimer
    Laboratory of Molecular Genetics, National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, 12618 Tallinn, Estonia
    Toxicology 269:182-9. 2010
    ..toxic effects of the copper compounds were not dependent on exposure time (4 and 24h), whereas the toxicity of zinc compounds was about 1.5 times lower after 24h of exposure than after 4h, probably due to adaptation...
  94. ncbi Comparison of measured dermal dust exposures with predicted exposures given by the EASE expert system
    Graeme W Hughson
    Institute of Occupational Medicine, Research Park North, Riccarton, Edinburgh EH14 4AP, UK
    Ann Occup Hyg 49:111-23. 2005
    ..were obtained from subjects in seven different workplaces that were producing or working with zinc metal or zinc compounds. The work activities were grouped a priori into one of three categories used by EASE for dermal exposure ..
  95. ncbi Zinc requirements and the risks and benefits of zinc supplementation
    Wolfgang Maret
    Department of Preventive Medicine and Community Health, Division of Human Nutrition, University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77555, USA
    J Trace Elem Med Biol 20:3-18. 2006
    ..health, where additional zinc might be efficacious to prevent certain conditions, point at the pharmacology of zinc compounds as a promising area...
  96. ncbi The influence of zinc on caspase-3 and DNA breakdown in cultured human retinal pigment epithelial cells
    J P Wood
    The Nuffield Laboratory of Ophthalmology, University of Oxford, Walton Street Oxford, OX2 6AW, England
    Arch Ophthalmol 119:81-8. 2001
    ..To investigate the role of extracellular zinc on the death process of cultured human retinal pigment epithelial (RPE) cells...
  97. ncbi Zinc and copper: proposed fortification levels and recommended zinc compounds
    Jorge L Rosado
    School of Natural Sciences, University of Queretaro, Mexico
    J Nutr 133:2985S-9S. 2003
    ..2-0.4 mg of copper depending on the habitual diet, magnitude of deficiencies and period of supplementation...
  98. ncbi Role of mast cells in gastrointestinal mucosal defense
    Alicia B Penissi
    Instituto de Histología y Embriología Dr Mario H Burgos IHEM CONICET, Facultad de Ciencias Medicas, Universidad Nacional de Cuyo, Casilla de Correo 56, 5500 Mendoza, Argentina
    Biocell 27:163-72. 2003
    ..These include zinc compounds, sodium cromoglycate, FPL 52694, ketotifen, aloe vera, certain flavonoids such as quercetin, some sulfated ..
  99. ncbi A novel zinc compound (zinc monocysteine) enhances the antioxidant capacity of human retinal pigment epithelial cells
    David J Tate
    Core Labs, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Curr Eye Res 31:675-83. 2006
    ..The aim of this study was to document the effect of a novel zinc amino acid combination on the concentrations of important antioxidants in cultured human retinal pigment epithelial (hRPE) cells...
  100. ncbi Preparation of a copoly (dl-lactic/glycolic acid)-zinc oxide complex and its utilization to microcapsules containing recombinant human growth hormone
    Yutaka Yamagata
    Pharmaceutical Research Division, Takeda Chemical Industries, Ltd, 17 85 Jusohonmachi 2 Chome, Yodogawa ku, Osaka 532 8686, Japan
    Int J Pharm 251:133-41. 2003
    ..Out of sparingly water-soluble zinc compounds, zinc oxide was most remarkably soluble in a PLGA/dichloromethane solution and the dissolution rates became ..
  101. doi Role of nutritional zinc in the prevention of osteoporosis
    Masayoshi Yamaguchi
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322 0001, USA
    Mol Cell Biochem 338:241-54. 2010
    ..b>Zinc compounds may be designed as new supplementation factor in the prevention and therapy of osteoporosis.

Research Grants88

  1. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2007
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  2. Localized Aggressive Periodontitis: Microbial & Host Markers for Susceptibility
    Daniel Fine; Fiscal Year: 2009
    ....
  3. SYNTHESIS OF MACROCYCLES STEROIDS CYCLOPENTANOIDS ETC
    BARRY TROST; Fiscal Year: 2001
    ..Ring expansion methods may convert these cores into the taxoid skeleton with appropriate functionality at key points for analog development. ..
  4. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  5. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2006
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  6. Attachment of Oral Actinobacillus to Epithelium
    Daniel Fine; Fiscal Year: 2007
    ..The longterm goal of this application is to use this information to identify targets for therapeutic agents that can interfere with attachment of Aa to oral tissues and thus prevent colonization leading to LAP. ..
  7. Oral Immunology/Microbiology Research Group Annual Mtg
    Daniel Fine; Fiscal Year: 2003
    ..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
  8. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 2007
    ..By expediting access to very diverse arrays of structural types, the best opportunities to discover new therapeutic agents arise. ..
  9. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 2004
    ..By accessing a very diverse range of structural types, the best opportunities to discover new therapeutic agents arise. ..
  10. Microbial Markers for Periodontal Disease in Children
    Daniel Fine; Fiscal Year: 2005
    ....
  11. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2007
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  12. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 1993
    ..The diversity of the challenges posed by antiviral and antitumor agents represent highly meaningful tests of their use...
  13. NOVEL SYNTHETIC APPROACHES TO ANTITUMOR COMPOUNDS
    BARRY TROST; Fiscal Year: 1992
    ..A strategy to one family of tumor promoters represented by teleocidin explores the concept of chemical chameleons. In most cases, the strategy also considers the problem of absolute stereochemistry...
  14. NOVEL APPROACHES TO ANTITUMOR AND ANTIVIRAL AGENTS
    BARRY TROST; Fiscal Year: 2000
    ..Equally important, new avenues to vary structure around these cores in order to establish structure-activity relationships with the aim to create better therapeutic agents become available. ..
  15. Oral Immunology/Microbiology Annual Meeting
    Daniel Fine; Fiscal Year: 2003
    ..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
  16. Localized Aggressive Periodontitis: Microbial & Host Markers for Susceptibility
    Daniel H Fine; Fiscal Year: 2010
    ....
  17. Novel Approaches for Antitumor and Antiviral Agents
    Barry M Trost; Fiscal Year: 2010
    ..This proposal helps to address this key challenge by developing the underlying initial technology within classes of compounds having demonstrably antitumor or antiviral activities. ..
  18. Synthesis of Macrolides. Steroids, Cyclopentanoids, etc
    BARRY TROST; Fiscal Year: 2005
    ..This new concept sets the stage for solutions to a long standing problem, the ion channel blockers, the grayanotoxins. as well as the more recently discovered rameswaralide, a potent antiinflamatory. ..
  19. Localized Aggressive Periodontitis: Microbial & Host Markers for Susceptibility
    Daniel Fine; Fiscal Year: 2009
    ....
  20. A Nanocrystal Biosensor for Detection of Multiple TBI Neurochemical Biomarkers
    Yongcheng Liu; Fiscal Year: 2007
    ..In comparison to existing technologies such as ELISA, this new technology will be more sensitive, reliable, specific, accurate, portable, robust, inexpensive and rapider to assess TBI. ..
  21. Zinc Fluorescence Biosensing and Imaging Technology
    Richard Thompson; Fiscal Year: 2007
    ..If successful, we anticipate that our technology will be of use in understanding and developing treatments for the conditions listed above. ..
  22. Dual Oxidase in Lung Epithelium
    Horst Fischer; Fiscal Year: 2009
    ..This research investigates a novel area of lung anti-microbial defense and will provide new information that may lead to therapeutic application. ..
  23. Dual Oxidase in Lung Epithelium
    HORST B FISCHER; Fiscal Year: 2011
    ..This research investigates a novel area of lung anti-microbial defense and will provide new information that may lead to therapeutic application. ..
  24. Dual Oxidase in Lung Epithelium
    HORST B FISCHER; Fiscal Year: 2010
    ..This research investigates a novel area of lung anti-microbial defense and will provide new information that may lead to therapeutic application. ..
  25. Image Reconstruction with Solid Srate SPECR
    LAWRENCE ZENG; Fiscal Year: 2005
    ..abstract_text> ..
  26. Regulation of Celluar Zinc Distribution
    Wolfgang Maret; Fiscal Year: 2004
    ..abstract_text> ..
  27. Radio-Immunotherapy (RIT) Planning Using SPECT
    LAWRENCE ZENG; Fiscal Year: 2004
    ..Novel image reconstruction algorithms will be developed to provided quantitative SPECT images. Our hypothesis will be verified through human observer studies and Channelized Hotelling observer studies. ..
  28. Nanoparticles for in vivo Oxygen Measurement in Tumors
    Wei Chen; Fiscal Year: 2005
    ..The combinations of these two techniques and the advantages of nanoparticle probes will enable the development a new oxygen sensor that can provide more accurate and more sensitive measurement of oxygen and oxygen-map imaging in vivo. ..
  29. Breast Cancer Imaging Using a Solid-State SPECT Camera
    G Zeng; Fiscal Year: 2005
    ..abstract_text> ..
  30. Morpholino Antisense Drugs for Hepatitis C Virus
    Nigel Bourne; Fiscal Year: 2004
    ..The proposed research, if successful, would lead to a application for Phase II funding to bring the use of PMOs into the HCV drug market and provide a well-tolerated, inexpensive alternative to current HCV treatments. ..
  31. Colloidal Quantum Dot/Well Near-Infrared NanoLabels
    Yongcheng Liu; Fiscal Year: 2006
    ..3). produce CdS/CdSe/CdTe or CdS/CdTe/CdSe quantum well type-ll nanocrystals by SILAR and develop standard procedures. 4). develop dendron-nanocrystals and box-nanocrystals by chemical modification of these nanocrystals. ..
  32. Immunization to Reduce Genital and Neonatal Herpes
    Nigel Bourne; Fiscal Year: 2006
    ..Taken together, the studies in this proposal will yield new information about the capacity of HSV vaccines to reduce the spread of genital herpes. These study designs may become standard for preclinical evaluation of HSV vaccines. ..
  33. NOX-mediated proton secretion by airways
    Horst Fischer; Fiscal Year: 2006
    ..This will help develop novel therapeutical targets for the treatment of airway acidity and inflammatory airway diseases. ..
  34. Scintillation Luminescence System for In-Vivo Dosimetry
    Wei Chen; Fiscal Year: 2005
    ..abstract_text> ..
  35. Activated Sugars for Drug Discovery
    Ryan Woodyer; Fiscal Year: 2006
    ..These sugars can be used to make derivatives of natural products with new therapeutic properties, for example, antibiotics that are effective against antibiotic-resistant bacteria. ..
  36. Complementary treatment approach to epilepsy
    Siegward Elsas; Fiscal Year: 2007
    ..At the end of the award period, Dr. Elsas will have completed a clinical trial of a botanical and will be well positioned to obtain independent research funding. ..
  37. Oligosaccharides Against Enteric Infections
    Ryan Woodyer; Fiscal Year: 2009
    ....
  38. Kits for Converting Nanocrystals to Standard Bio-Medical Reagents
    Yongcheng Liu; Fiscal Year: 2007
    ..Such opportunities are needed for the State of Arkansas to meet its long term mission, to develop this traditionally rural state to a knowledge- based and environmentally benign industry harbor. ..