thiocarbamates

Summary

Summary: Carbamates in which the -CO- group has been replaced by a -CS- group.

Top Publications

  1. ncbi Nuclear factor-kappaB contributes to infarction after permanent focal ischemia
    Antti Nurmi
    A I Virtanen Institute, Department of Neurobiology, University of Kuopio, Kuopio, Finland
    Stroke 35:987-91. 2004
  2. doi Oral administration of pyrrolidine dithiocarbamate (PDTC) inhibits VEGF expression, tumor angiogenesis, and growth of breast cancer in female mice
    Jian Wei Gu
    Department of Physiology and Biophysics, University of Mississippi Medical Center Jackson, MS 39216, USA
    Cancer Biol Ther 8:514-21. 2009
  3. ncbi Potential contribution of nuclear factor-kappaB to cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits
    Meng Liang Zhou
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China
    J Cereb Blood Flow Metab 27:1583-92. 2007
  4. ncbi Pyrrolidine dithiocarbamate inhibits translocation of nuclear factor kappa-B in neurons and protects against brain ischaemia with a wide therapeutic time window
    Antti Nurmi
    A I Virtanen Institute, Department of Neurobiology, University of Kuopio, FIN 70211 Kuopio, Finland
    J Neurochem 91:755-65. 2004
  5. doi Inhibition of nuclear factor kappa B transcription activity drives a synergistic effect of pyrrolidine dithiocarbamate and cisplatin for treatment of renal cell carcinoma
    Christudas Morais
    Department of Renal Medicine, Royal Brisbane and Women s Hospital, Herston, QLD, Australia
    Apoptosis 15:412-25. 2010
  6. ncbi Pyrrolidine dithiocarbamate inhibition of luteolin-induced apoptosis through up-regulated phosphorylation of Akt and caspase-9 in human leukemia HL-60 cells
    An Chin Cheng
    Department of Physical Therapy, Shu Zen College of Medicine and Management, Kaohsiung County, Taiwan
    J Agric Food Chem 54:4215-21. 2006
  7. ncbi Novel modifications in the series of O-(2-phthalimidoethyl)-N-substituted thiocarbamates and their ring-opened congeners as non-nucleoside HIV-1 reverse transcriptase inhibitors
    Andrea Spallarossa
    Dipartimento di Scienze Farmaceutiche, Universita di Genova, Viale Benedetto XV 3, I 16132 Genova, Italy
    Eur J Med Chem 44:1650-63. 2009
  8. doi Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Parallel synthesis, molecular modelling and structure-activity relationship studies on O-[2-(hetero)arylethyl]-N-phenylthiocarbamates
    Sara Cesarini
    Dipartimento di Scienze Farmaceutiche, Universita di Genova, Viale Benedetto XV 3, I 16132 Genova, Italy
    Bioorg Med Chem 16:4160-72. 2008
  9. ncbi Prevention of cancer cachexia by pyrrolidine dithiocarbamate (PDTC) in colon 26 tumor-bearing mice
    Yong jun Nai
    Research Institute of General Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China
    JPEN J Parenter Enteral Nutr 31:18-25. 2007
  10. ncbi Cell death in human acute myelogenous leukemic cells induced by pyrrolidinedithiocarbamate
    L Malaguarnera
    Department of Bio Medical Sciences, University of Catania, Italy
    Apoptosis 8:539-45. 2003

Detail Information

Publications200 found, 100 shown here

  1. ncbi Nuclear factor-kappaB contributes to infarction after permanent focal ischemia
    Antti Nurmi
    A I Virtanen Institute, Department of Neurobiology, University of Kuopio, Kuopio, Finland
    Stroke 35:987-91. 2004
    ..Because a considerable number of middle cerebral artery occlusions (MCAOs) in humans are not associated with reperfusion during the first 24 hours, the role of NF-kappaB after permanent MCAO (pMCAO) was investigated...
  2. doi Oral administration of pyrrolidine dithiocarbamate (PDTC) inhibits VEGF expression, tumor angiogenesis, and growth of breast cancer in female mice
    Jian Wei Gu
    Department of Physiology and Biophysics, University of Mississippi Medical Center Jackson, MS 39216, USA
    Cancer Biol Ther 8:514-21. 2009
    ..These results support the hypothesis that PDTC suppresses tumor angiogenesis, growth, and migration of breast cancer via inhibiting autocrine and paracrine effects of VEGF through the reduction of NFκB activation and VEGF expression...
  3. ncbi Potential contribution of nuclear factor-kappaB to cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits
    Meng Liang Zhou
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China
    J Cereb Blood Flow Metab 27:1583-92. 2007
    ..Our results suggest that NF-kappaB is activated in the arterial wall after SAH, which potentially leads to vasospasm development through induction of inflammatory response...
  4. ncbi Pyrrolidine dithiocarbamate inhibits translocation of nuclear factor kappa-B in neurons and protects against brain ischaemia with a wide therapeutic time window
    Antti Nurmi
    A I Virtanen Institute, Department of Neurobiology, University of Kuopio, FIN 70211 Kuopio, Finland
    J Neurochem 91:755-65. 2004
    ..The clinically approved PDTC and its analogues may act as anti-inflammatories and may be safe therapies in stroke with a wide time window...
  5. doi Inhibition of nuclear factor kappa B transcription activity drives a synergistic effect of pyrrolidine dithiocarbamate and cisplatin for treatment of renal cell carcinoma
    Christudas Morais
    Department of Renal Medicine, Royal Brisbane and Women s Hospital, Herston, QLD, Australia
    Apoptosis 15:412-25. 2010
    ..The major mechanism of the synergistic effect appears to be mediated by the inhibition of transcription activity of NF-kappaB rather than its expression, and the resultant decrease in the anti-apoptotic proteins Bcl-2 and Bcl-(XL)...
  6. ncbi Pyrrolidine dithiocarbamate inhibition of luteolin-induced apoptosis through up-regulated phosphorylation of Akt and caspase-9 in human leukemia HL-60 cells
    An Chin Cheng
    Department of Physical Therapy, Shu Zen College of Medicine and Management, Kaohsiung County, Taiwan
    J Agric Food Chem 54:4215-21. 2006
    ..These results suggest that in the luteolin-induced apoptotic pathway, phosphorylation of procaspase-9 by survival signals might play an important role in the ultimate fate of HL-60 cells...
  7. ncbi Novel modifications in the series of O-(2-phthalimidoethyl)-N-substituted thiocarbamates and their ring-opened congeners as non-nucleoside HIV-1 reverse transcriptase inhibitors
    Andrea Spallarossa
    Dipartimento di Scienze Farmaceutiche, Universita di Genova, Viale Benedetto XV 3, I 16132 Genova, Italy
    Eur J Med Chem 44:1650-63. 2009
    The structure-activity relationships (SARs) of N-aryl-O-(2-phthalimidoethyl)thiocarbamates (C-TCs) and their imide ring-opened congeners (O-TCs) as non-nucleoside HIV-1 reverse transcriptase inhibitors were further investigated...
  8. doi Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Parallel synthesis, molecular modelling and structure-activity relationship studies on O-[2-(hetero)arylethyl]-N-phenylthiocarbamates
    Sara Cesarini
    Dipartimento di Scienze Farmaceutiche, Universita di Genova, Viale Benedetto XV 3, I 16132 Genova, Italy
    Bioorg Med Chem 16:4160-72. 2008
    In order to expand the structure-activity relationship (SAR) studies on Thiocarbamates (TCs), a recently discovered class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors, 38 analogues of the lead O-[2-(2-pyridyl)ethyl]-N-..
  9. ncbi Prevention of cancer cachexia by pyrrolidine dithiocarbamate (PDTC) in colon 26 tumor-bearing mice
    Yong jun Nai
    Research Institute of General Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China
    JPEN J Parenter Enteral Nutr 31:18-25. 2007
    ..This study was aimed to assess the effect of pyrrolidine dithiocarbamate (PDTC, an inhibitor of NFkappaB) on interleukin (IL)-6 synthesis and cachexia in colon 26 tumor-bearing mice...
  10. ncbi Cell death in human acute myelogenous leukemic cells induced by pyrrolidinedithiocarbamate
    L Malaguarnera
    Department of Bio Medical Sciences, University of Catania, Italy
    Apoptosis 8:539-45. 2003
    ..These findings imply that normal cells are equipped with mechanisms by which they respond differently to PDTC effects with respect to leukemic cells...
  11. doi Pre-clinical safety evaluation of pyrrolidine dithiocarbamate
    Monika Chabicovsky
    MC Toxicology Consulting, Vienna, Austria
    Basic Clin Pharmacol Toxicol 107:758-67. 2010
    ..Blood and tissue samples were obtained from PDTC-treated rats to analyse pharmacokinetics and tissue distribution. Accumulation of selected metals due to PDTC treatment was examined in liver, brain, nerves and fat tissues...
  12. doi Fetal bovine serum requirement for pyrrolidine dithiocarbamate-induced apoptotic cell death of MCF-7 breast tumor cells
    Da Hee Oh
    East West Bone and Joint Research Institute, East West Neo Medical Center, Kyung Hee University, 149 Sangil dong, Gangdong gu, Seoul, Republic of Korea
    Eur J Pharmacol 649:135-9. 2010
    ....
  13. pmc Relative inhibitory potency of molinate and metabolites with aldehyde dehydrogenase 2: implications for the mechanism of enzyme inhibition
    Erin M G Allen
    Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242, USA
    Chem Res Toxicol 23:1843-50. 2010
    ..It was determined that molinate sulfone is capable of covalently modifying Cys residues, including catalytic Cys302 of ALDH, accounting for the observed enzyme inhibition...
  14. ncbi Constitutively active NFkappa B is required for the survival of S-type neuroblastoma
    Xin Bian
    Department of Pediatrics, University of Michigan, Ann Arbor 48109, USA
    J Biol Chem 277:42144-50. 2002
    ..This study demonstrates a role for NFkappaB in the survival of S-type NB tumor cells and suggests that NFkappaB activity and function differ according to NB tumor cell phenotype...
  15. ncbi Inhibition of nuclear factor-kappaB activation reduces cortical tubulointerstitial injury in proteinuric rats
    G K Rangan
    Department of Renal Medicine, University of Sydney at Westmead Hospital, Australia
    Kidney Int 56:118-34. 1999
    ..We hypothesized that in vivo inhibition of renal NF-kappaB activation would reduce interstitial monocyte infiltration in a rat model of nonimmune proteinuric tubulointerstitial inflammation...
  16. ncbi Pyrrolidine dithiocarbamate reduces lung injury caused by mesenteric ischemia/reperfusion in a rat model
    Burhan Kabay
    Department of General Surgery, Pamukkale University, School of Medicine, 20070, Denizli, Turkey
    World J Surg 31:1707-15. 2007
    ..It has been shown to attenuate local harmful effects of ischemia/reperfusion (I/R) injury in many organs. In this study, we aimed to study the effect of PDTC on lung reperfusion injury induced by superior mesenteric occlusion...
  17. pmc Antiviral effects of pyrrolidine dithiocarbamate on human rhinoviruses
    Elisabeth Gaudernak
    Institute of Medical Biochemistry, University of Vienna, Vienna Biocenter, A 1030 Vienna, Austria
    J Virol 76:6004-15. 2002
    ..Synthesis of HRV proteins and cleavage of eucaryotic initiation factor 4G responsible for host cell shutoff of cellular protein synthesis are severely inhibited in the presence of PDTC...
  18. ncbi Novel biphasic effect of pyrrolidine dithiocarbamate on neuronal cell viability is mediated by the differential regulation of intracellular zinc and copper ion levels, NF-kappaB, and MAP kinases
    K C Chung
    Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea
    J Neurosci Res 59:117-25. 2000
    ..These results suggest that the thiol groups and free zinc and copper ion levels are important for the novel biphasic PDTC effect on cell viability, which is associated with the differential activation of NF-kappaB and MAP kinases...
  19. ncbi Effect of antioxidants on apoptosis induced by influenza virus infection: inhibition of viral gene replication and transcription with pyrrolidine dithiocarbamate
    Noboru Uchide
    Department of Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Japan
    Antiviral Res 56:207-17. 2002
    ..The synthesis of specific viral macromolecules at the early stage of infection may play a critical role in the mechanism of apoptosis induction and moderate ROS overproduction may not be involved in the mechanism...
  20. ncbi Pyrrolidine dithiocarbamate is a potent antioxidant against hypochlorous acid-induced protein damage
    Ben Zhan Zhu
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512, USA
    FEBS Lett 532:80-4. 2002
    ..These data demonstrate that PDTC is a potent antioxidant against HOCl-induced protein oxidative damage, suggesting that PDTC might be useful in the prevention and treatment of inflammatory conditions...
  21. ncbi Metabolic activation of herbicide products by Vicia faba detected in human peripheral lymphocytes using alkaline single cell gel electrophoresis
    María Elena Calderón-Segura
    Laboratorios de Citogenética y Mutagénesis Ambientales, Centro de Ciencias de la Atmosfera, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Coyoacan, 04510 Mexico DF, Mexico
    Toxicol In Vitro 21:1143-54. 2007
    ..The alkaline comet technique is a rapid and sensitive assay, to quickly evaluate DNA damage the metabolic activation of herbicide products by V. faba root in human cells in vitro...
  22. ncbi Antiviral function of pyrrolidine dithiocarbamate against influenza virus: the inhibition of viral gene replication and transcription
    Noboru Uchide
    Department of Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    J Antimicrob Chemother 52:8-10. 2003
  23. ncbi Helicobacter pylori-induced expression of interleukin-8 and cyclooxygenase-2 in AGS gastric epithelial cells: mediation by nuclear factor-kappaB
    H Kim
    Dept. of Pharmacology and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
    Scand J Gastroenterol 36:706-16. 2001
    ..H. pylori-induced expression of IL-8 and COX-2 was blocked in AGS cells transfected with p50 AS ODN. CONCLUSION: NF-kappaB may play a novel role in expression of IL-8 and COX-2 in H. pylori-induced gastric inflammation...
  24. doi Pyrrolidine dithiocarbamate activates p38 MAPK and protects brain endothelial cells from apoptosis: a mechanism for the protective effect in stroke?
    Waltraud Pfeilschifter
    Klinik fur Neurologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Neurochem Res 35:1391-401. 2010
    ..The attenuation of apoptotic cell death in brain microvascular endothelial cells is dependent on p38 MAPK activity...
  25. pmc Influence of NFkappaB inhibitors on IL-1beta-induced chemokine CXCL8 and -10 expression levels in intestinal epithelial cell lines: glucocorticoid ineffectiveness and paradoxical effect of PDTC
    Yeruva Sunil
    Centre for Internal Medicine, Department of Gastroenterology and Endocrinology, University of Goettingen, Goettingen, Germany
    Int J Colorectal Dis 25:323-33. 2010
    ..Therefore, we aimed to evaluate the efficacy of compounds known to disrupt the NFkappaB pathway on NFkappaB transcriptional activity and CXCL8 and CXCL10 gene expression in intestinal cell lines...
  26. ncbi Pyrrolidine dithiocarbamate induces apoptosis by a cytochrome c-dependent mechanism
    F Della Ragione
    Institute of Biochemistry of Macromolecules, Second University of Naples, Naples, Italy
    Biochem Biophys Res Commun 268:942-6. 2000
    ....
  27. doi Anti-angiogenic actions of pyrrolidine dithiocarbamate, a nuclear factor kappa B inhibitor
    Christudas Morais
    Department of Renal Medicine, Royal Brisbane and Women s Hospital, Herston, QLD, Australia
    Angiogenesis 12:365-79. 2009
    ..Collectively, these data suggest that PDTC has some anti-angiogenic properties, which may limit development and progression of RCC...
  28. doi Role of intrapulmonary expression of inducible nitric oxide synthase gene and nuclear factor kappaB activation in severe pancreatitis-associated lung injury
    Shi hai Kan
    Department of Human Anatomy, Binzhou Medical University, No 346 Guanhai Road, Yantai, 264003, China
    Inflammation 33:287-94. 2010
    ..PDTC might inhibit the activation of NF-kappaB and then reduce the expression of iNOSmRNA and effectively alleviate the severity of lung injury...
  29. ncbi Photodegradation of the herbicide EPTC and the safener dichlormid, alone and in combination
    Aqel W Abu-Qare
    Environmental, Agricultural and Analytical Chemistry, Department of Chemistry, University of Glasgow, Scotland, UK
    Chemosphere 46:1183-9. 2002
    ..The findings showed that dichlormid did not significantly affect EPTC photodegradation either at 254 nm or at > 290 nm. The biological/toxicological properties of the photoproducts need further study, particularly the dimer compounds...
  30. doi Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors: docking-based CoMFA and CoMSIA analyses
    Elena Cichero
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Genova, Viale Benedetto XV n 3, 16132 Genova Italy
    Eur J Med Chem 44:2059-70. 2009
    b>Thiocarbamates (TCs) have been recently identified as a new class of potent non-nucleoside HIV-1 Reverse Transcriptase (RT) inhibitors...
  31. pmc Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B
    C Wahl
    Department of Internal Medicine I, University of Ulm, D 89081 Ulm, Germany
    J Clin Invest 101:1163-74. 1998
    ..These results demonstrate that sulfasalazine is a potent and specific inhibitor of NF-kappaB activation, and thus may explain some of the known biological properties of sulfasalazine...
  32. ncbi PDTC, metal chelating compound, induces G1 phase cell cycle arrest in vascular smooth muscle cells through inducing p21Cip1 expression: involvement of p38 mitogen activated protein kinase
    Sung Kwon Moon
    National Research Laboratory for Glycobiology, Korean Ministry of Science and Technology, Kyungju, Kyungbuk, Korea
    J Cell Physiol 198:310-23. 2004
    ..In conclusion, an understanding of the molecular mechanisms of PDTC in VSMC provides a theoretical basis for clinical approaches using antioxidant therapies in atherosclerosis...
  33. ncbi Inhibition of prostate cancer cellular proteasome activity by a pyrrolidine dithiocarbamate-copper complex is associated with suppression of proliferation and induction of apoptosis
    Di Chen
    Barbara Ann Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Front Biosci 10:2932-9. 2005
    ....
  34. ncbi HIV-1 Tat protein-induced VCAM-1 expression in human pulmonary artery endothelial cells and its signaling
    Kai Liu
    Department of Medicine, Tulane Univ School of Medicine, New Orleans, LA 70112 2699, USA
    Am J Physiol Lung Cell Mol Physiol 289:L252-60. 2005
    ....
  35. pmc Degradation of the thiocarbamate herbicide EPTC (S-ethyl dipropylcarbamothioate) and biosafening by Rhodococcus sp. strain NI86/21 involve an inducible cytochrome P-450 system and aldehyde dehydrogenase
    I Nagy
    F A Janssens Laboratory of Genetics, Catholic University of Leuven, Heverless, Belgium
    J Bacteriol 177:676-87. 1995
    ..strain NI86/21. In addition to the major metabolite N-depropyl EPTC, another degradation product was identified, EPTC-sulfoxide...
  36. ncbi Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis
    Toni Ahtoniemi
    Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, PO B 1627, FIN 70211 Kuopio, Finland
    Mol Pharmacol 71:30-7. 2007
    ..These results suggest that PDTC acts as an immunoproteasome inhibitor in mutant SOD1 rats and that immunoproteasome may help the nervous system to cope with deleterious effects of SOD1-G93A mutation...
  37. ncbi Agricultural exposure to carbamate pesticides and risk of non-Hodgkin lymphoma
    T Zheng
    Yale University School of Public Health, USA
    J Occup Environ Med 43:641-9. 2001
    ..These results suggest an increased risk of NHL associated with carbamate pesticide use, particularly Sevin. Further investigation of the association is warranted...
  38. ncbi Characterization of S-(N,N-Dialkylaminocarbonyl)cysteine Adducts and Enzyme Inhibition Produced by Thiocarbamate Herbicides in the Rat
    Lisa J Zimmerman
    Department of Pathology and Center in Molecular Toxicology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2561, USA
    Chem Res Toxicol 17:258-67. 2004
    b>Thiocarbamates are a major class of herbicides used extensively in the agricultural industry...
  39. ncbi NF-kappa B activation mediates doxorubicin-induced cell death in N-type neuroblastoma cells
    X Bian
    Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan 48109-0938, USA
    J Biol Chem 276:48921-9. 2001
    ..Together these findings show that NF-kappa B activation mediates doxorubicin-induced cell death without evidence of caspase function and suggest that cisplatin and doxorubicin engage different death pathways to kill neuroblastoma cells...
  40. ncbi Differential involvement of NF-kappaB and MAP kinase pathways in the generation of inflammatory cytokines by human neutrophils
    Alexandre Cloutier
    Pulmonary Division, Faculty of Medicine, Universite de Sherbrooke, 3001, 12e Avenue Nord, pièce 4849, Sherbrooke, Quebec, Canada
    J Leukoc Biol 81:567-77. 2007
    ..Our data also raise the possibility that NF-kappaB or MAPK inhibitors could be useful in the treatment of inflammatory disorders in which neutrophils predominate...
  41. ncbi Angiotensin induces inflammatory activation of human vascular smooth muscle cells
    R Kranzhofer
    Departments of Cardiology and Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Arterioscler Thromb Vasc Biol 19:1623-9. 1999
    ..Inflammatory activation of the vessel wall by a dysregulated renin-angiotensin system may contribute to the pathogenesis of atherosclerosis...
  42. ncbi Pyrrolidine dithiocarbamate provides protection against hypothermic preservation and transplantation injury in the rat liver: the role of heme oxygenase-1
    Sei Ichiro Tsuchihashi
    Department of Surgery, Research Institute for Artificial Organs, Transplantation and Gene Therapy, Sapporo Hokuyu Hospital, Sapporo, Japan
    Surgery 133:556-67. 2003
    ..We examined the impact of PDTC preconditioning against cold ischemia and reperfusion injury in the rat liver...
  43. ncbi Inhibition of nuclear factor-kappaB by an antioxidant enhances paclitaxel sensitivity in ovarian carcinoma cell line
    G H Liu
    Department of Obstetrics and Gynecology, Yantai Yuhuangding Hospital, Yantai, Shandong, People s Republic of China
    Int J Gynecol Cancer 16:1777-82. 2006
    ..Combining antioxidants and paclitaxel has significant potential to overcome the risk of paclitaxel resistance...
  44. ncbi Potential contribution of NF-kappaB in neuronal cell death in the glutathione peroxidase-1 knockout mouse in response to ischemia-reperfusion injury
    Peter J Crack
    Centre for Functional Genomics and Human Disease, Monash Institute of Medical Research, Monash University, Melbourne, Australia
    Stroke 37:1533-8. 2006
    ..This study was designed to elucidate the mechanisms involved in elevated neuronal cell death arising from an altered endogenous oxidant state...
  45. ncbi Pyrrolidine dithiocarbamate protects against thioacetamide-induced fulminant hepatic failure in rats
    Rafael Bruck
    Department of Gastroenterology, E Wolfson Medical Center, 58100, Holon, Israel
    J Hepatol 36:370-7. 2002
    ....
  46. ncbi Suppression of experimental abdominal aortic aneurysms in mice by treatment with pyrrolidine dithiocarbamate, an antioxidant inhibitor of nuclear factor-kappaB
    Federico E Parodi
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, One Barnes Jewish Hospital Plaza, St Louis, MO 63110, USA
    J Vasc Surg 41:479-89. 2005
    ..The purpose of this study was to determine whether aneurysmal degeneration is influenced by pyrrolidine dithiocarbamate (PDTC), a pharmacologic inhibitor of NF-kappaB...
  47. pmc Copper uptake is required for pyrrolidine dithiocarbamate-mediated oxidation and protein level increase of p53 in cells
    Saori Furuta
    Department of Chemistry and Biochemistry, California State University at Los Angeles, 5151 State University Drive, Los Angeles, CA 90032, U S A
    Biochem J 365:639-48. 2002
    ..At copper accumulation levels higher than 60 microg/g of cellular protein, p53 is oxidized. These results suggest that p53 is vulnerable to free radical-mediated oxidation at cysteine residues...
  48. ncbi Linoleic acid-induced expression of inducible nitric oxide synthase and cyclooxygenase II via p42/44 mitogen-activated protein kinase and nuclear factor-kappaB pathway in retinal pigment epithelial cells
    I Mo Fang
    Department of Ophthalmology, National Taiwan University Hospital, No 7, Chung Shan S Rd, Taipei, Taiwan
    Exp Eye Res 85:667-77. 2007
    ..These results may provide new insights into both mechanisms of LA action on RPE cells and pathogenesis of age-related macular degeneration...
  49. ncbi N-acetylcysteine inhibits induction of nitric oxide synthase in 3T3-L1 adipocytes
    Shunsuke Araki
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan
    J UOEH 29:417-29. 2007
    ..These results suggest that NAC regulates iNOS expression and NO production in adipocytes through the modulating activation of NF-kappa B...
  50. ncbi Arginine vasopressin increases iNOS-NO system activity in cardiac fibroblasts through NF-kappaB activation and its relation with myocardial fibrosis
    Yan Hong Fan
    Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, 17 Changlexi Street, Xi an 710032, PR China
    Life Sci 81:327-35. 2007
    ..NO production induced by AVP may counteract the profibrotic effects of AVP, thus the development of MF perhaps depends on the balance between profibrotic AVP and antifibrotic NO effects on MF...
  51. doi Differential effects of pyrrolidine dithiocarbamate on TNF-alpha-mediated liver injury in two different models of fulminant hepatitis
    Jin wei Lu
    Department of Toxicology, Anhui Medical University, Hefei, China
    J Hepatol 48:442-52. 2008
    ..The present study aimed to investigate the effects of PDTC on lipopolysaccharide (LPS)-induced liver injury in two different models of fulminant hepatitis...
  52. ncbi Activation of nuclear factor-kappa B and effects of pyrrolidine dithiocarbamate on TNBS-induced rat colitis
    Ken Chen
    Department of Clinical Medicine, Guangdong College of Pharmacy, Guangzhou 510224, Guangdong Province, China
    World J Gastroenterol 11:1508-14. 2005
    ....
  53. ncbi Antioxidant attenuates acute lung injury after cardiopulmonary bypass in rats
    Li Zhong Wang
    Department of Anesthesiology, Jiaxing Women and Children s Health Hospital, 42 Jinjian Rd, Jiaxing 314000, Zhejiang Province, China
    Asian Cardiovasc Thorac Ann 15:2-8. 2007
    ..It was concluded that cardiopulmonary bypass can directly induce acute lung injury, and pyrrolidine dithiocarbamate attenuates this injury by inhibiting nuclear factor-kappaB activity...
  54. ncbi In vivo suppressive effect of nuclear factor-kappaB inhibitor on neutrophilic inflammation of grafts after orthotopic liver transplantation in rats
    Xiao Ping Gu
    Department of Hepatobiliary Surgery, Drum Tower Hospital, Medical Department of Nanjing University, Nanjing 210008, Jiangsu Province, China
    World J Gastroenterol 10:3654-8. 2004
    ....
  55. ncbi Upregulation of cyclooxygenase-2 by motorcycle exhaust particulate-induced reactive oxygen species enhances rat vascular smooth muscle cell proliferation
    Huei Ping Tzeng
    Institute of Toxicology and Department of Orthopaedics, College of Medicine, National Taiwan University, Taipei, Taiwan
    Chem Res Toxicol 20:1170-6. 2007
    ..Taken together, these findings suggest that MEPE may contribute to the enhancement of the pathogenesis of cardiovascular diseases by augmenting proliferation of VSMCs through a ROS-regulated ERK1/2-activated COX-2 signaling pathway...
  56. doi Effect of pyrrolidine dithiocarbamate on hepatic vascular stress gene expression during ischemia and reperfusion
    Chan Ho Lee
    College of Pharmacy, Sungkyunkwan University, Suwon, South Korea
    Eur J Pharmacol 595:100-7. 2008
    ..In a rat model of hepatic ischemia and reperfusion, our results suggest that the hepatoprotective actions of pyrrolidine dithiocarbamate may be mediated in part through the modulation of imbalanced expression of vascular stress genes...
  57. ncbi Regulation of tumor necrosis factor-alpha production in the isolated rat heart stimulated by bacterial lipopolysaccharide or reactive oxygen
    G Russell Jennings
    Department of Surgery, Mercer University School of Medicine, Macon, Georgia, USA
    Am Surg 70:797-800. 2004
    ..Forskolin almost completely blocked TNF release stimulated by LPS or ROS. These data are consistent with the notion that inhibitors of NF-kappaB block cytokine production stimulated by some agents but not others...
  58. ncbi Inhibition of the nuclear factor-kappaB activation with pyrrolidine dithiocarbamate attenuating inflammation and oxidative stress after experimental spinal cord trauma in rats
    Giovanni La Rosa
    Neurosurgical Clinic and Institute of Pharmacology, University of Messina School of Medicine, Messina, Italy
    J Neurosurg Spine 1:311-21. 2004
    ..Dithiocarbamates are antioxidants that are potent inhibitors of NF-kappaB. The authors postulated that pyrrolidine dithiocarbamate (PDTC) would attenuate NF-kappaB-related inflammatory and oxidative events that occur after SCI...
  59. ncbi A pathway involving protein kinase Cdelta up-regulates cytosolic phospholipase A(2)alpha in airway epithelium
    Hye Jin You
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Republic of Korea
    Biochem Biophys Res Commun 321:657-64. 2004
    ..Our results suggest that PKCdelta and ROS lie upstream of NF-kappaB, and we conclude that a PKCdelta-ROS-NF-kappaB cascade plays a pivotal role in cPLA(2)alpha induction by PMA...
  60. ncbi Nuclear factor-kappaB inhibition by pyrrolidinedithiocarbamate attenuates gastric ischemia-reperfusion injury in rats
    Eman El Eter
    Physiology Department, Medical College and King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
    Can J Physiol Pharmacol 83:483-92. 2005
    ..PDTC protects against gastric I/R injury by an antioxidant, NF-kappaB inhibition, and by reduction of pro-apoptotic protein p53 expression, which seems to be downstream to NF-kappaB, thus promoting cell survival...
  61. pmc Redox regulation of cytokine-mediated inhibition of myelin gene expression in human primary oligodendrocytes
    Malabendu Jana
    Section of Neuroscience, Department of Oral Biology, University of Nebraska Medical Center, Lincoln, NE 68583, USA
    Free Radic Biol Med 39:823-31. 2005
    ..Taken together, these studies suggest that proinflammatory cytokines inhibit the expression of myelin genes in human primary oligodendrocytes through the alteration of cellular redox...
  62. ncbi The NF-kappaB inhibitors attenuate hepatic injury in bile duct ligated rats
    Savas Demirbilek
    Inonu University School of Medicine, Malatya, Turkey
    Pediatr Surg Int 22:655-63. 2006
    ..These results indicate that inhibitors of NF-kappaB activity such as PDTB and sulfasalazine exert a therapeutic effect on cholestatic liver injury in rats with BDL through anti-inflammatory and antioxidant actions...
  63. ncbi Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibition
    Anna Csiszar
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 291:H1694-9. 2006
    ..We propose that these anti-inflammatory actions of resveratrol are responsible, at least in part, for its cardioprotective effects...
  64. ncbi [Expression of nuclear factor-kappa B and effect of pyrrolidine dithiocarbamate in Pseudomonas aeruginosa pneumonia rat model]
    Wen shu Chai
    Department of Infectious Disease, The First Affiliated Hospital of China Medical University, Shenyang 110001, China
    Zhonghua Nei Ke Za Zhi 46:815-9. 2007
    ..To investigate the expression of nuclear factor-kappa B (NF-kappaB) and cytokines in Pseudomonas aeruginosa (PA)-induced pneumonia of rats, and the effect of pyrrolidine dithiocarbamate (PDTC)...
  65. ncbi Regulation of ALP activity by TNF-alpha on human dental pulp
    Tatsu Okabe
    Department of Endodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, Japan
    J Endod 32:516-20. 2006
    ..Smad7 expression in HDP cells was increased by TNF-alpha, but decreased by PDTC treatment. These results suggest that NF- kappaB and Smad7 play an important role in the down regulation of ALP activity by TNF-alpha on HDP cells...
  66. pmc Evaluation of the effect of pyrrolidine dithiocarbamate in suppressing inflammation in mice with dextran sodium sulfate-induced colitis
    Ichiro Hirata
    Department of Gastroenterology, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    World J Gastroenterol 13:1666-71. 2007
    ..To evaluate the effect of pyrrolidine dithio-carbamate (PDTC; an NF-kappaB inhibitor) administered at low (50 mg/kg) and high (100 mg/kg) doses in suppressing colitis in mice with dextran sodium sulfate (DSS)-induced colitis...
  67. ncbi Angiotensin II induces monocyte chemoattractant protein-1 expression via a nuclear factor-kappaB-dependent pathway in rat preadipocytes
    Kyoichiro Tsuchiya
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8513, Japan
    Am J Physiol Endocrinol Metab 291:E771-8. 2006
    ..Thus the augmented MCP-1 expression by ANG II in preadipocytes may provide a new link between obesity and cardiovascular disease...
  68. ncbi [Inhibition of nuclear factor kappa B attenuates multiple organ injury following ruptured abdominal aortic aneurysm: an experiment with rats]
    Jun Yang
    Department of Surgery, First Affiliated Hospital, China Medical University, Shenyang 110001, China
    Zhonghua Yi Xue Za Zhi 86:237-41. 2006
    ..To investigate the effect of inhibition of nuclear factor kappa B on multiple organ injury following ruptured abdominal aortic aneurysm...
  69. ncbi Differential suppression of endotoxin-inducible inflammatory cytokines by nuclear factor kappa B (NFkappaB) inhibitor in rat microglia
    Kazuyuki Nakajima
    Department of Bioinformatics, Faculty of Engineering, Soka University, Hachioji, Tokyo 192 8577, Japan
    Neurosci Lett 401:199-202. 2006
    ..Taken together, these results suggest that the induction of IL-1beta and TNFalpha in endotoxin-stimulated microglia is differentially regulated at the level of NFkappaB activation...
  70. ncbi N-Acetyl-L-cysteine and pyrrolidine dithiocarbamate inhibited nuclear factor-kappaB activation in alveolar macrophages by different mechanisms
    Ya qing Li
    Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Acta Pharmacol Sin 27:339-46. 2006
    ....
  71. ncbi Increased cyclooxygenase-2 expression in hypothalamic paraventricular nucleus in rats with heart failure: role of nuclear factor kappaB
    Yang Yu
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hypertension 49:511-8. 2007
    ..By enhancing access of prostaglandin E2 to hypothalamic neurons, this mechanism may contribute to augmented sympathetic nerve activity in HF...
  72. ncbi Distinct inhibitory mechanisms of isoquercitrin gallate and its aglycone on zymosan-induced peroxynitrite production in macrophages
    Byung Hak Kim
    College of Pharmacy and Research Center for Bioresource and Health, Chungbuk National University, Cheongju 361 763, Republic of Korea
    Nitric Oxide 17:134-42. 2007
    ..Taken together, Q-32 and quercetin could provide invaluable tools to investigate zymosan-induced oxidative stress with distinct antioxidant mechanisms...
  73. ncbi The cumulative effect of nuclear factor-kappaB (NF-kappaB) inhibition and endothelins in early cerulein-induced acute pancreatitis in rats
    J W Długosz
    Department of Gastroenterology and Internal Medicine, Medical University of Białystok, Poland
    Rocz Akad Med Bialymst 50:230-6. 2005
    ..To assess effects of NF-kappaB activation inhibitor (pyrrolidine dithiocarbamate--PDTC) alone or with endothelins (ET-1, ET-2, ET-3) in early course of cerulein-induced acute pancreatitis (AP) in rats...
  74. ncbi Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanism
    Hsinyu Lee
    Department of Life Science and Institute of Zoology, National Taiwan University, Taipei, Taiwan 106, ROC
    Am J Physiol Cell Physiol 287:C1657-66. 2004
    ....
  75. ncbi [The expression of nuclear factor-kappa B in lipopolysaccharide-induced keratitis of rats and the effect of pyrrolidine dithiocarbamate on its expression]
    Xin yi Wu
    Department of Ophthalmology, Qilu Hospital, Shandong University, Jinan 250012, China
    Zhonghua Yan Ke Za Zhi 42:699-703. 2006
    ..To investigate the expression of nuclear factor-kappa B (NF-kappaB) and cytokines in lipopolysaccharide (LPS)-induced keratitis of rats, and the effect of pyrrolidine dithiocarbamate (PDTC) on its expression...
  76. ncbi Interactions between angiotensin II and NF-kappaB-dependent pathways in modulating macrophage infiltration in experimental diabetic nephropathy
    Fiona T H Lee
    Danielle Alberti Memorial Centre for Diabetic Complications, Vascular Division, Baker Medical Research Institute, Melbourne 8008, Australia
    J Am Soc Nephrol 15:2139-51. 2004
    ..In the context of the known proinflammatory effects of AII, it is postulated that the renoprotection conferred by angiotensin II receptor antagonism is at least partly related to the inhibition of NF-kappaB-dependent pathways...
  77. ncbi Pyrrolidine dithiocarbamate reduces the severity of cerulein-induced murine acute pancreatitis
    Ioannis Virlos
    Hepatobiliary Unit, Department of Surgery, Manchester Royal Infirmary, Manchester, United Kingdom
    Shock 20:544-50. 2003
    ....
  78. ncbi Inhibitory effects of pyrrolidine dithiocarbamate on endotoxin-induced uveitis in Lewis rats
    Kouichi Ohta
    Department of Ophthalmology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Invest Ophthalmol Vis Sci 43:744-50. 2002
    ..To determine the effect of pyrrolidine dithiocarbamate (PDTC), an antioxidant nuclear factor (NF)-kappaB inhibitor, on the ocular inflammation induced by lipopolysaccharide (LPS)...
  79. ncbi CD40 ligand (CD40L) does not stimulate proliferation of vascular smooth muscle cells
    Alexander Hermann
    Institut fur Pharmakologie und Klinische Pharmakologie, Universitatsklinikum Dusseldorf, Germany
    Eur J Cell Biol 81:213-21. 2002
    ..Finally, sCD40L did not induce SMC migration. From these data it is concluded that CD40L activates mitogenic signalling and DNA synthesis but does not contribute to proliferation or migration of vascular SMC...
  80. ncbi Effects of TNFalpha on expression of ICAM-1 in human airway epithelial cells in vitro: oxidant-mediated pathways and transcription factors
    Thomas M Krunkosky
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    Free Radic Biol Med 35:1158-67. 2003
    ....
  81. ncbi Acid exposure stimulates the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells: effects on platelet-activating factor receptor expression
    S Ishizuka
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
    Am J Respir Cell Mol Biol 24:459-68. 2001
    ..Increased adherence of S. pneumoniae may be one of the reasons why pneumonia develops after gastric juice aspiration...
  82. ncbi Ethanol induces rapid lipid peroxidation and activation of nuclear factor-kappa B in cerebral vascular smooth muscle: relation to alcohol-induced brain injury in rats
    Burton M Altura
    Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA
    Neurosci Lett 325:95-8. 2002
    ....
  83. ncbi Glucocorticoids induced the production and gene expression of IL-1alpha through AP-1 and partially NF-kappaB activation in murine epidermal cells
    Sherif Awad
    Department of Dermatology and Immunodermatology, Graduate School, Tokyo Medical and Dental University, Japan
    J Med Dent Sci 49:27-35. 2002
    ..These data indicated that lower concentration of glucocorticoids induced the augmentation of IL-1alpha production from keratinocytes mediated through the AP-1 pathway and partially through NF-kappaB pathway...
  84. ncbi Nuclear factor-kappa B p65 mediates the assembly and activation of the TNF-responsive element of the murine monocyte chemoattractant-1 gene
    D Ping
    Department of Microbiology and Immunology, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA
    J Immunol 162:727-34. 1999
    ..This study illustrates the crucial role for NF-kappa B p65 in the induction of the MCP-1 gene by TNF and in the assembly of a NF-kappa B dependent enhancer in vivo...
  85. ncbi NF-kappaB activation is detrimental in arginine-induced acute pancreatitis
    Zoltan Rakonczay
    First Department of Medicine, University of Szeged, Szeged, Hungary
    Free Radic Biol Med 34:696-709. 2003
    ..The increased levels of HSPs most probably act to limit the severity of the disease...
  86. ncbi Phosphoinositide 3-kinase activity leads to silica-induced NF-kappaB activation through interacting with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB
    Jihee Lee Kang
    Department of Physiology, College of Medicine, Division of Cell Biology, Ewha Medical Research Center, Ewha Womans University, Seoul, Korea
    Mol Cell Biochem 248:17-24. 2003
    ..Our data suggest that p85 and p110 subunits of PI3-kinase play a role in NF-kappaB activation through interaction with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB...
  87. ncbi Hyperoxia upregulates the NO pathway in alveolar macrophages in vitro: role of AP-1 and NF-kappaB
    S Pepperl
    Institute for Surgical Research, Klinikum Grosshadern, University of Munich, D-81366 Munich, Germany
    Am J Physiol Lung Cell Mol Physiol 280:L905-13. 2001
    ..The results presented here indicate that hyperoxia can upregulate the NO pathway in stimulated AMs through increased production of intracellular ROS and activation of NF-kappaB and AP-1...
  88. ncbi Hyperoxia elicits myocardial protection through a nuclear factor kappaB-dependent mechanism in the rat heart
    Peeter Tähepõld
    Crafoord Laboratory of Experimental Surgery, Karolinska Hospital, Stockholm, Sweden
    J Thorac Cardiovasc Surg 125:650-60. 2003
    ..In the present study we investigated whether the cardioprotective effects of hyperoxia were dependent on the redox-sensitive transcription factor nuclear factor kappaB...
  89. ncbi Specific pancreatic enzymes activate macrophages to produce tumor necrosis factor-alpha: role of nuclear factor kappa B and inhibitory kappa B proteins
    C Jaffray
    Department of Surgery, University of South Florida, Tampa, FL 33601, USA
    J Gastrointest Surg 4:370-7; discussion 377-8. 2000
    ..This process is dependent on I kappa B-beta degradation and NF- kappa B activation, suggesting that these enzymes trigger this second messenger system through specific membrane-bound receptors...
  90. ncbi Endotoxin stress-response in cardiomyocytes: NF-kappaB activation and tumor necrosis factor-alpha expression
    Gary Wright
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol Heart Circ Physiol 282:H872-9. 2002
    ..Taken together, these results reveal that NF-kappaB is not only involved in cytokine production but also may be linked to other pathways that subserve a constitutive, protective mechanism for the heart cell...
  91. ncbi Peroxynitrite mediates cytokine-induced IL-8 gene expression and production by human leukocytes
    C Zouki
    Research Center, Maisonneuve-Rosemont Hospital, , H1T 2M4, Canada
    J Leukoc Biol 69:815-24. 2001
    ..These results indicate that ONOO(-) formation may underlie the action of cytokines towards IL-8 gene expression in human leukocytes...
  92. ncbi Role of caspase in CD80 expression of superantigen-stimulated monocytes
    Fumiaki Shinohara
    Department of Microbiology and Immunology, Tohoku University Graduate School of Dentistry, Aoba ku, Sendai 980 8575, Japan
    Int J Mol Med 14:241-6. 2004
    ..These results indicated that CD80 driven by NF-kappaB is regulated by the enzymatic actions of caspases, which allows monocytes to participate in massive T-cell activation...
  93. ncbi Role of renin-angiotensin system and nuclear factor-kappaB in the obstructed kidney of rats with unilateral ureteral obstruction
    Tatsuya Nakatani
    Department of Urology, Osaka City University, Japan
    Jpn J Pharmacol 90:361-4. 2002
    ..These results suggest that the beneficial effects of angiotensin blockade are mediated by the inhibition of oxidative stress and subsequent NF-kappaB activation in obstructive nephropathy...
  94. ncbi Pyrrolidine dithiocarbamate added to University of Wisconsin solution inhibits reperfusion injury after orthotopic liver transplantation in rats
    Xiao Ping Gu
    Department of Anesthesiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, People s Republic of China
    Ann Clin Lab Sci 34:187-94. 2004
    ..A therapeutic strategy directed at inhibition of NF-kappaB activation within the transplanted liver might be effective in reducing intrahepatic neutrophilic inflammation, and be beneficial to prolonged graft storage...
  95. ncbi Effects of antioxidants and nitric oxide on TNF-alpha-induced adhesion molecule expression and NF-kappaB activation in human dermal microvascular endothelial cells
    Mi Zu Jiang
    Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    Life Sci 75:1159-70. 2004
    ..These results suggest a potential therapeutic approach using antioxidant agents or nitric oxide pathway modulators in the treatment of inflammatory skin diseases...
  96. ncbi A protective effect of pyrrolidine dithiocarbamate in a rat model of liver cirrhosis
    Rafael Bruck
    Department of Gastroenterology, The E Wolfson Medical Center, Holon, Israel
    Liver Int 24:169-76. 2004
    ..The aim of the present study was to examine the efficacy of PDTC in a chronic rat model of thioacetamide (TAA)-induced hepatic fibrosis...
  97. ncbi [Activation of nuclear factor kappa B in newborn rats sepsis]
    Feng Pan
    Department of Pediatrics, Daping Hospital, The Third Military Medical University, Chongqing, 400042, China
    Zhonghua Er Ke Za Zhi 41:582-5. 2003
    ..The aim of the study is to explore the effect of NF-kappa B signal pathway in neonatal sepsis so as to provide the experimental base for corresponding clinical treatment of the sepsis, in which NF-kappa B is taken as the target...
  98. ncbi Induction of MMP-9 in normal human bronchial epithelial cells by TNF-alpha via NF-kappa B-mediated pathway
    A Hozumi
    First Department of Internal Medicine, Kobe University School of Medicine, Kobe 650-0017, Japan
    Am J Physiol Lung Cell Mol Physiol 281:L1444-52. 2001
    ..These results suggest that TNF-alpha induces the expression of MMP-9 in human bronchial epithelial cells and that this induction is mediated via the NF-kappa B-mediated pathway...
  99. ncbi Endothelial apoptosis induced by oxidative stress through activation of NF-kappaB: antiapoptotic effect of antioxidant agents on endothelial cells
    M Aoki
    Department of Geriatric Medicine, Osaka University Medical School, Osaka, Japan
    Hypertension 38:48-55. 2001
    ..Oxidative stress may play an important role in endothelial apoptosis mediated by hypoxia, through the activation of NF-kappaB...
  100. ncbi Role of nuclear factor-kappaB in a rat model of vascular injury
    A Ialenti
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    Naunyn Schmiedebergs Arch Pharmacol 364:343-50. 2001
    ..These results indicate that prevention of NF-kappaB activation may lead to the inhibition of neointima formation and suggest that antioxidant agents may have therapeutic relevance for the prevention of human restenosis...
  101. ncbi Antioxidants attenuate reperfusion injury after global brain ischemia through inhibiting nuclear factor-kappa B activity in rats
    Wan Hua Shen
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, Xuzhou 221002, China
    Acta Pharmacol Sin 24:1125-30. 2003
    ..To investigate the effects of two antioxidants on the alterations of nuclear factor kappaB (NF-kappaB) activity and p65, p50 protein expression and phosphorylation of IkappaBalpha in rat hippocampus following global brain ischemia...

Research Grants104 found, 100 shown here

  1. iNOS Posttranslational Regulation in Cardiac Rejection
    GALEN PIEPER; Fiscal Year: 2006
    ..A better understanding of this molecular process may lead to better strategies to prevent injury cardiac cells in these patients. [unreadable] [unreadable] [unreadable]..
  2. MOLECULAR TARGETS OF NITRIC OXIDE IN CARDIAC TRANSPLANTS
    GALEN PIEPER; Fiscal Year: 2003
    ..These studies will provide a novel mechanism to explain the pathogenesis of dyskinesis and graft failure during cardiac transplant rejection. ..
  3. MOLECULAR TARGETS OF NITRIC OXIDE IN CARDIAC TRANSPLANTS
    GALEN PIEPER; Fiscal Year: 2004
    ..These studies will provide a novel mechanism to explain the pathogenesis of dyskinesis and graft failure during cardiac transplant rejection. ..
  4. MOLECULAR TARGETS OF NITRIC OXIDE IN CARDIAC TRANSPLANTS
    GALEN PIEPER; Fiscal Year: 2002
    ..These studies will provide a novel mechanism to explain the pathogenesis of dyskinesis and graft failure during cardiac transplant rejection. ..
  5. iNOS Posttranslational Regulation in Cardiac Rejection
    GALEN PIEPER; Fiscal Year: 2007
    ..A better understanding of this molecular process may lead to better strategies to prevent injury cardiac cells in these patients. [unreadable] [unreadable] [unreadable]..
  6. MOLECULAR TARGETS OF NITRIC OXIDE IN CARDIAC TRANSPLANTS
    GALEN PIEPER; Fiscal Year: 2001
    ..These studies will provide a novel mechanism to explain the pathogenesis of dyskinesis and graft failure during cardiac transplant rejection. ..
  7. iNOS Posttranslational Regulation in Cardiac Rejection
    GALEN PIEPER; Fiscal Year: 2008
    ..A better understanding of this molecular process may lead to better strategies to prevent injury cardiac cells in these patients. ..
  8. iNOS Posttranslational Regulation in Cardiac Rejection
    GALEN PIEPER; Fiscal Year: 2009
    ..A better understanding of this molecular process may lead to better strategies to prevent injury cardiac cells in these patients. ..
  9. Lung carcinogenesis: Chemoprevention by Indole-3-carbinol
    Fekadu Kassie; Fiscal Year: 2009
    ..Proving the hypothesis that indole-3-carbinol (I3C) inhibits lung tumorigenesis in A/J mouse model provides a solid platform for clinical trials of I3C as a chemopreventive agent against lung cancer. ..
  10. Tobacco Carcinogenesis
    Stephen Hecht; Fiscal Year: 2005
    ..Steven Tannenbaum (MIT), Dr. Jack Henningfield (Johns Hopkins and Pinney Associates), Drs. Jeffrey Seeman and Anthony Tricker (Philip Morris), and Dr. John Lauterbach (an independent consultant, formerly with Brown and Williamson). ..
  11. DETECTION OF DNA ADDUCTS OF PULMONARY CARCINOGENS BY AMS
    Stephen Hecht; Fiscal Year: 2004
    ..abstract not provided ..
  12. DNA Adducts of the Carcinogen Acetaldehyde
    Stephen Hecht; Fiscal Year: 2006
    ..The results of the research proposed here will provide critical data, which will be the framework for testing our hypothesis that acetaldehyde is a human carcinogen. ..
  13. Benzo(a) pyrene Metabolism: Phenotyping and Genotyping
    Stephen Hecht; Fiscal Year: 2005
    ....
  14. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2005
    ..abstract_text> ..
  15. DNA Adducts of the Carcinogen Acetaldehyde
    Stephen Hecht; Fiscal Year: 2005
    ..The results of the research proposed here will provide critical data, which will be the framework for testing our hypothesis that acetaldehyde is a human carcinogen. ..
  16. Benzo(a) pyrene Metabolism: Phenotyping and Genotyping
    Stephen Hecht; Fiscal Year: 2004
    ....
  17. Lung carcinogenesis: Chemoprevention by Indole-3-carbinol
    Fekadu Kassie; Fiscal Year: 2010
    ..Proving the hypothesis that indole-3-carbinol (I3C) inhibits lung tumorigenesis in A/J mouse model provides a solid platform for clinical trials of I3C as a chemopreventive agent against lung cancer. ..
  18. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2004
    ..abstract_text> ..
  19. DNA Adducts of the Carcinogen Acetaldehyde
    Stephen S Hecht; Fiscal Year: 2010
    ..These studies will provide critical data on the occurrence and biological significance of acetaldehyde DNA adducts and their possible role in human cancer. ..
  20. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen Hecht; Fiscal Year: 2004
    ..This grant proposal will replace the corresponding portion of the Principal Investigator's Outstanding Investigator Grant, as the latter program is being phased out by the National Cancer Institute. ..
  21. DNA Adducts of the Carcinogen Acetaldehyde
    Stephen Hecht; Fiscal Year: 2004
    ..The results of the research proposed here will provide critical data, which will be the framework for testing our hypothesis that acetaldehyde is a human carcinogen. ..
  22. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen S Hecht; Fiscal Year: 2010
    ..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
  23. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2006
    ..abstract_text> ..
  24. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen Hecht; Fiscal Year: 2003
    ..This grant proposal will replace the corresponding portion of the Principal Investigator's Outstanding Investigator Grant, as the latter program is being phased out by the National Cancer Institute. ..
  25. Benzo[a]pyrene metabolism: phenotyping and genotyping
    Stephen Hecht; Fiscal Year: 2008
    ..The results of this study will greatly improve our understanding of PAH metabolism in humans and could ultimately lead to a predictive algorithm for lung cancer risk in smokers. Such information is vital for lung cancer prevention. ..
  26. DNA Adducts of the Carcinogen Acetaldehyde
    Stephen Hecht; Fiscal Year: 2008
    ..These studies will provide critical data on the occurrence and biological significance of acetaldehyde DNA adducts and their possible role in human cancer. ..
  27. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen Hecht; Fiscal Year: 2008
    ..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
  28. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2008
    ..abstract_text> ..
  29. DNA Adducts of the Carcinogen Acetaldehyde
    Stephen Hecht; Fiscal Year: 2009
    ..These studies will provide critical data on the occurrence and biological significance of acetaldehyde DNA adducts and their possible role in human cancer. ..
  30. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen Hecht; Fiscal Year: 2009
    ..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
  31. Metabolism of Carcinogenic Tobacco-Specific Nitrosamines
    Stephen Hecht; Fiscal Year: 2008
    ....
  32. Benzo[a]pyrene metabolism: phenotyping and genotyping
    Stephen Hecht; Fiscal Year: 2007
    ..The results of this study will greatly improve our understanding of PAH metabolism in humans and could ultimately lead to a predictive algorithm for lung cancer risk in smokers. Such information is vital for lung cancer prevention. ..
  33. DNA Adducts of the Carcinogen Acetaldehyde
    Stephen Hecht; Fiscal Year: 2007
    ..These studies will provide critical data on the occurrence and biological significance of acetaldehyde DNA adducts and their possible role in human cancer. ..
  34. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen Hecht; Fiscal Year: 2007
    ..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
  35. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2007
    ..abstract_text> ..
  36. Benzo[a]pyrene metabolism: phenotyping and genotyping
    Stephen Hecht; Fiscal Year: 2009
    ..The results of this study will greatly improve our understanding of PAH metabolism in humans and could ultimately lead to a predictive algorithm for lung cancer risk in smokers. Such information is vital for lung cancer prevention. ..
  37. Metabolism of Carcinogenic Tobacco-Specific Nitrosamines
    Stephen Hecht; Fiscal Year: 2007
    ....
  38. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen Hecht; Fiscal Year: 2006
    ..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
  39. Benzo[a]pyrene metabolism: phenotyping and genotyping
    Stephen S Hecht; Fiscal Year: 2010
    ..The results of this study will greatly improve our understanding of PAH metabolism in humans and could ultimately lead to a predictive algorithm for lung cancer risk in smokers. Such information is vital for lung cancer prevention. ..
  40. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen Hecht; Fiscal Year: 2001
    ..This grant proposal will replace the corresponding portion of the Principal Investigator's Outstanding Investigator Grant, as the latter program is being phased out by the National Cancer Institute. ..
  41. MECHANISM(S) OF CHEMICAL LEUKEMOGENESIS
    Richard Irons; Fiscal Year: 1993
    ....
  42. Benzo(a) pyrene Metabolism: Phenotyping and Genotyping
    Stephen Hecht; Fiscal Year: 2002
    ....
  43. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2000
    ..abstract_text> ..
  44. MECHANISM(S) OF CHEMICAL LEUKEMOGENESIS
    Richard Irons; Fiscal Year: 2000
    ..A. in specific sub-populations of CD34+ human BM cells. Finally, patterns of gene expression will be correlated with genotype, phenotype and functional clonogenic response in BM cells obtained from patients with MDS or evolving sAML. ..
  45. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2002
    ..abstract_text> ..
  46. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen Hecht; Fiscal Year: 2002
    ..This grant proposal will replace the corresponding portion of the Principal Investigator's Outstanding Investigator Grant, as the latter program is being phased out by the National Cancer Institute. ..
  47. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2001
    ..abstract_text> ..
  48. Benzo(a) pyrene Metabolism--Phenotyping and Genotyping
    Stephen Hecht; Fiscal Year: 2001
    ....
  49. DNA Adducts of the Carcinogen Acetaldehyde
    Stephen Hecht; Fiscal Year: 2002
    ..The results of the research proposed here will provide critical data, which will be the framework for testing our hypothesis that acetaldehyde is a human carcinogen. ..
  50. MECHANISM(S) OF CHEMICAL LEUKEMOGENESIS
    Richard Irons; Fiscal Year: 2001
    ..A. in specific sub-populations of CD34+ human BM cells. Finally, patterns of gene expression will be correlated with genotype, phenotype and functional clonogenic response in BM cells obtained from patients with MDS or evolving sAML. ..
  51. MECHANISM(S) OF CHEMICAL LEUKEMOGENESIS
    Richard Irons; Fiscal Year: 2002
    ..A. in specific sub-populations of CD34+ human BM cells. Finally, patterns of gene expression will be correlated with genotype, phenotype and functional clonogenic response in BM cells obtained from patients with MDS or evolving sAML. ..
  52. MECHANISM(S) OF CHEMICAL LEUKEMOGENESIS
    Richard Irons; Fiscal Year: 1999
    ..A. in specific sub-populations of CD34+ human BM cells. Finally, patterns of gene expression will be correlated with genotype, phenotype and functional clonogenic response in BM cells obtained from patients with MDS or evolving sAML. ..
  53. DNA Adducts of the Carcinogen Acetaldehyde
    Stephen Hecht; Fiscal Year: 2003
    ..The results of the research proposed here will provide critical data, which will be the framework for testing our hypothesis that acetaldehyde is a human carcinogen. ..
  54. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2003
    ..abstract_text> ..
  55. Benzo(a) pyrene Metabolism: Phenotyping and Genotyping
    Stephen Hecht; Fiscal Year: 2003
    ....
  56. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 1999
    ..abstract_text> ..
  57. Chemokines, nitric oxide, and myocardial depression
    Bysani Chandrasekar; Fiscal Year: 2002
    ..The results from these studies will further our knowledge of chemokine biology and lead to new therapeutic strategies to prevent or treat myocardial dysfunction in ischemia-reperfusion injury. ..
  58. Mechanisms of methyl dithiocarbamate immunotoxicity
    Stephen B Pruett; Fiscal Year: 2010
    ..It is also expected that the detailed study of three important mechanisms of action, which will be examined in each aim, can be generalized to other situations or toxicants that alter these parameters. ..
  59. GASTROINTESTINAL PEPTIDE SIGNALING THROUGH PKC/PKD
    JUAN ENRIQUE ROZENGURT; Fiscal Year: 2010
    ....
  60. MECHANISMS OF IMMUNOSUPPRESSION BY ONE DOSE OF ETHANOL
    Stephen Pruett; Fiscal Year: 2001
    ..These results have implications for human health, because even moderate EtOH consumption increased the incidence of cancer and many persons with EtOH-associated cancers have decreased NK cell function. ..
  61. Mechanisms of Immunotoxcity of Chemical Stressors
    Stephen Pruett; Fiscal Year: 2001
    ....
  62. Mechanisms of methyl dithiocarbamate immunotoxicity
    Stephen Pruett; Fiscal Year: 2009
    ..It is also expected that the detailed study of three important mechanisms of action, which will be examined in each aim, can be generalized to other situations or toxicants that alter these parameters. ..
  63. MECHANISMS OF IMMUNOSUPPRESSION BY ONE DOSE OF ETHANOL
    Stephen Pruett; Fiscal Year: 2000
    ..These results have implications for human health, because even moderate EtOH consumption increased the incidence of cancer and many persons with EtOH-associated cancers have decreased NK cell function. ..
  64. Mechanisms of methyl dithiocarbamate immunotoxicity
    Stephen Pruett; Fiscal Year: 2008
    ..It is also expected that the detailed study of three important mechanisms of action, which will be examined in each aim, can be generalized to other situations or toxicants that alter these parameters. ..
  65. GI PEPTIDE SIGNALING THROUGH TYROSINE PHOSPHORYLATION
    JUAN ENRIQUE ROZENGURT; Fiscal Year: 2010
    ....
  66. MECHANISMS OF IMMUNOSUPPRESSION BY ONE DOSE OF ETHANOL
    Stephen Pruett; Fiscal Year: 2007
    ..abstract_text> ..
  67. Mechanisms of methyl dithiocarbamate immunotoxicity
    Stephen B Pruett; Fiscal Year: 2010
    ..It is also expected that the detailed study of three important mechanisms of action, which will be examined in each aim, can be generalized to other situations or toxicants that alter these parameters. ..
  68. GASTROINTESTINAL PEPTIDE SIGNALING THROUGH PKC/PKD
    JUAN ENRIQUE ROZENGURT; Fiscal Year: 2010
    ....
  69. GASTROINTESTINAL PEPTIDE SIGNALING THROUGH PKC/PKD
    JUAN ROZENGURT; Fiscal Year: 2007
    ..abstract_text> ..
  70. GASTROINTESTINAL PEPTIDE SIGNALING THROUGH PKC/PKD
    JUAN ROZENGURT; Fiscal Year: 2002
    ....
  71. Mechanisms of Immunotoxcity of Chemical Stressors
    Stephen Pruett; Fiscal Year: 2003
    ....
  72. Mechanisms of Immunotoxcity of Chemical Stressors
    Stephen Pruett; Fiscal Year: 2005
    ....
  73. GASTROINTESTINAL PEPTIDE SIGNALING THROUGH PKC/PKD
    JUAN ROZENGURT; Fiscal Year: 2004
    ..abstract_text> ..
  74. MECHANISMS OF IMMUNOSUPPRESSION BY ONE DOSE OF ETHANOL
    Stephen Pruett; Fiscal Year: 2003
    ..These results have implications for human health, because even moderate EtOH consumption increased the incidence of cancer and many persons with EtOH-associated cancers have decreased NK cell function. ..
  75. GI PEPTIDE SIGNALING THROUGH TYROSINE PHOSPHORYLATION
    JUAN ROZENGURT; Fiscal Year: 2003
    ..2b) Determine the role of EGFR transactivation in signaling GI peptide-mediated mitogenesis. 2c) Characterize GPCR-induced transactivation of EGFR in IEC-6 cells. ..
  76. GI PEPTIDE SIGNALING THROUGH TYROSINE PHOSPHORYLATION
    JUAN ROZENGURT; Fiscal Year: 2002
    ..2b) Determine the role of EGFR transactivation in signaling GI peptide-mediated mitogenesis. 2c) Characterize GPCR-induced transactivation of EGFR in IEC-6 cells. ..
  77. GI PEPTIDE SIGNALING THROUGH TYROSINE PHOSPHORYLATION
    JUAN ROZENGURT; Fiscal Year: 2004
    ..2b) Determine the role of EGFR transactivation in signaling GI peptide-mediated mitogenesis. 2c) Characterize GPCR-induced transactivation of EGFR in IEC-6 cells. ..
  78. GASTROINTESTINAL PEPTIDE SIGNALING THROUGH PKC/PKD
    JUAN ROZENGURT; Fiscal Year: 2003
    ..abstract_text> ..
  79. MECHANISMS OF IMMUNOSUPPRESSION BY ONE DOSE OF ETHANOL
    Stephen Pruett; Fiscal Year: 2005
    ..abstract_text> ..
  80. MECHANISMS OF IMMUNOSUPPRESSION BY ONE DOSE OF ETHANOL
    Stephen Pruett; Fiscal Year: 2002
    ..These results have implications for human health, because even moderate EtOH consumption increased the incidence of cancer and many persons with EtOH-associated cancers have decreased NK cell function. ..
  81. GI PEPTIDE SIGNALING THROUGH TYROSINE PHOSPHORYLATION
    JUAN ROZENGURT; Fiscal Year: 2006
    ....
  82. GASTROINTESTINAL PEPTIDE SIGNALING THROUGH PKC/PKD
    JUAN ROZENGURT; Fiscal Year: 2001
    ....
  83. GASTROINTESTINAL PEPTIDE SIGNALING THROUGH PKC/PKD
    JUAN ROZENGURT; Fiscal Year: 2006
    ..abstract_text> ..
  84. MECHANISMS OF IMMUNOSUPPRESSION BY ONE DOSE OF ETHANOL
    Stephen Pruett; Fiscal Year: 2006
    ..abstract_text> ..
  85. CURE: DIGESTIVE DISEASES RESEARCH CENTER
    JUAN ROZENGURT; Fiscal Year: 2008
    ....
  86. GASTROINTESTINAL PEPTIDE SIGNALING THROUGH PKC/PKD
    JUAN ROZENGURT; Fiscal Year: 2001
    ....
  87. GASTROINTESTINAL PEPTIDE SIGNALING THROUGH PKC/PKD
    JUAN ROZENGURT; Fiscal Year: 2009
    ....
  88. GI PEPTIDE SIGNALING THROUGH TYROSINE PHOSPHORYLATION
    JUAN ROZENGURT; Fiscal Year: 2008
    ....
  89. The Mechanism of Lung Chemoprevention Mediated by ITCs
    Yang Ming Yang; Fiscal Year: 2005
    ..In this project, our primary goal is to examine the chemopreventive effects of ITCs in mitotic checkpoint deficient mice as well as the effects of ITCs on mitotic checkpoint regulation. ..
  90. GASTROINTESTINAL PEPTIDE SIGNALING THROUGH PKC/PKD
    JUAN ROZENGURT; Fiscal Year: 1999
    ....
  91. Mechanisms of Immunotoxcity of Chemical Stressors
    Stephen Pruett; Fiscal Year: 2004
    ....
  92. Mechanisms of Immunotoxcity of Chemical Stressors
    Stephen Pruett; Fiscal Year: 2002
    ....
  93. GASTROINTESTINAL PEPTIDE SIGNALING THROUGH PKC/PKD
    JUAN ROZENGURT; Fiscal Year: 2005
    ..abstract_text> ..