Genomes and Genes
Summary: Carbamates in which the -CO- group has been replaced by a -CS- group.
Publications176 found, 100 shown here
- Novel biphasic effect of pyrrolidine dithiocarbamate on neuronal cell viability is mediated by the differential regulation of intracellular zinc and copper ion levels, NF-kappaB, and MAP kinasesK C Chung
Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea
J Neurosci Res 59:117-25. 2000..These results suggest that the thiol groups and free zinc and copper ion levels are important for the novel biphasic PDTC effect on cell viability, which is associated with the differential activation of NF-kappaB and MAP kinases...
- Helicobacter pylori-induced expression of interleukin-8 and cyclooxygenase-2 in AGS gastric epithelial cells: mediation by nuclear factor-kappaBH Kim
Dept. of Pharmacology and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
Scand J Gastroenterol 36:706-16. 2001..H. pylori-induced expression of IL-8 and COX-2 was blocked in AGS cells transfected with p50 AS ODN. CONCLUSION: NF-kappaB may play a novel role in expression of IL-8 and COX-2 in H. pylori-induced gastric inflammation...
- Pyrrolidine dithiocarbamate reduces lung injury caused by mesenteric ischemia/reperfusion in a rat modelBurhan Kabay
Department of General Surgery, Pamukkale University, School of Medicine, 20070, Denizli, Turkey
World J Surg 31:1707-15. 2007..It has been shown to attenuate local harmful effects of ischemia/reperfusion (I/R) injury in many organs. In this study, we aimed to study the effect of PDTC on lung reperfusion injury induced by superior mesenteric occlusion...
- Role of intrapulmonary expression of inducible nitric oxide synthase gene and nuclear factor kappaB activation in severe pancreatitis-associated lung injuryShi hai Kan
Department of Human Anatomy, Binzhou Medical University, No 346 Guanhai Road, Yantai, 264003, China
Inflammation 33:287-94. 2010..PDTC might inhibit the activation of NF-kappaB and then reduce the expression of iNOSmRNA and effectively alleviate the severity of lung injury...
- Pyrrolidine dithiocarbamate is a potent antioxidant against hypochlorous acid-induced protein damageBen-Zhan Zhu
Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331-6512, USA
FEBS Lett 532:80-4. 2002..These data demonstrate that PDTC is a potent antioxidant against HOCl-induced protein oxidative damage, suggesting that PDTC might be useful in the prevention and treatment of inflammatory conditions...
- Influence of NFkappaB inhibitors on IL-1beta-induced chemokine CXCL8 and -10 expression levels in intestinal epithelial cell lines: glucocorticoid ineffectiveness and paradoxical effect of PDTCYeruva Sunil
Centre for Internal Medicine, Department of Gastroenterology and Endocrinology, University of Goettingen, Goettingen, Germany
Int J Colorectal Dis 25:323-33. 2010..Therefore, we aimed to evaluate the efficacy of compounds known to disrupt the NFkappaB pathway on NFkappaB transcriptional activity and CXCL8 and CXCL10 gene expression in intestinal cell lines...
- Agricultural exposure to carbamate pesticides and risk of non-Hodgkin lymphomaT Zheng
Yale University School of Public Health, USA
J Occup Environ Med 43:641-9. 2001..These results suggest an increased risk of NHL associated with carbamate pesticide use, particularly Sevin. Further investigation of the association is warranted...
- Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosisToni Ahtoniemi
Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, PO B 1627, FIN 70211 Kuopio, Finland
Mol Pharmacol 71:30-7. 2007..These results suggest that PDTC acts as an immunoproteasome inhibitor in mutant SOD1 rats and that immunoproteasome may help the nervous system to cope with deleterious effects of SOD1-G93A mutation...
- HIV-1 Tat protein-induced VCAM-1 expression in human pulmonary artery endothelial cells and its signalingKai Liu
Department of Medicine, Tulane Univ School of Medicine, New Orleans, LA 70112 2699, USA
Am J Physiol Lung Cell Mol Physiol 289:L252-60. 2005....
- NF-kappa B activation mediates doxorubicin-induced cell death in N-type neuroblastoma cellsX Bian
Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan 48109-0938, USA
J Biol Chem 276:48921-9. 2001..Together these findings show that NF-kappa B activation mediates doxorubicin-induced cell death without evidence of caspase function and suggest that cisplatin and doxorubicin engage different death pathways to kill neuroblastoma cells...
- Degradation of the thiocarbamate herbicide EPTC (S-ethyl dipropylcarbamothioate) and biosafening by Rhodococcus sp. strain NI86/21 involve an inducible cytochrome P-450 system and aldehyde dehydrogenaseI Nagy
F A Janssens Laboratory of Genetics, Catholic University of Leuven, Heverless, Belgium
J Bacteriol 177:676-87. 1995..strain NI86/21. In addition to the major metabolite N-depropyl EPTC, another degradation product was identified, EPTC-sulfoxide...
- Photodegradation of the herbicide EPTC and the safener dichlormid, alone and in combinationAqel W Abu-Qare
Environmental, Agricultural and Analytical Chemistry, Department of Chemistry, University of Glasgow, Scotland, UK
Chemosphere 46:1183-9. 2002..The findings showed that dichlormid did not significantly affect EPTC photodegradation either at 254 nm or at > 290 nm. The biological/toxicological properties of the photoproducts need further study, particularly the dimer compounds...
- PDTC, metal chelating compound, induces G1 phase cell cycle arrest in vascular smooth muscle cells through inducing p21Cip1 expression: involvement of p38 mitogen activated protein kinaseSung-Kwon Moon
National Research Laboratory for Glycobiology, Korean Ministry of Science and Technology, Kyungju, Kyungbuk, Korea
J Cell Physiol 198:310-23. 2004..In conclusion, an understanding of the molecular mechanisms of PDTC in VSMC provides a theoretical basis for clinical approaches using antioxidant therapies in atherosclerosis...
- Angiotensin induces inflammatory activation of human vascular smooth muscle cellsR Kranzhofer
Departments of Cardiology and Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
Arterioscler Thromb Vasc Biol 19:1623-9. 1999..Inflammatory activation of the vessel wall by a dysregulated renin-angiotensin system may contribute to the pathogenesis of atherosclerosis...
- Characterization of S-(N,N-Dialkylaminocarbonyl)cysteine Adducts and Enzyme Inhibition Produced by Thiocarbamate Herbicides in the RatLisa J Zimmerman
Department of Pathology and Center in Molecular Toxicology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2561, USA
Chem Res Toxicol 17:258-67. 2004b>Thiocarbamates are a major class of herbicides used extensively in the agricultural industry...
- Inhibition of prostate cancer cellular proteasome activity by a pyrrolidine dithiocarbamate-copper complex is associated with suppression of proliferation and induction of apoptosisDi Chen
Barbara Ann Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Front Biosci 10:2932-9. 2005....
- Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa BC Wahl
Department of Internal Medicine I, University of Ulm, D 89081 Ulm, Germany
J Clin Invest 101:1163-74. 1998..These results demonstrate that sulfasalazine is a potent and specific inhibitor of NF-kappaB activation, and thus may explain some of the known biological properties of sulfasalazine...
- Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors: docking-based CoMFA and CoMSIA analysesElena Cichero
Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Genova, Viale Benedetto XV n 3, 16132 Genova Italy
Eur J Med Chem 44:2059-70. 2009b>Thiocarbamates (TCs) have been recently identified as a new class of potent non-nucleoside HIV-1 Reverse Transcriptase (RT) inhibitors...
- Copper uptake is required for pyrrolidine dithiocarbamate-mediated oxidation and protein level increase of p53 in cellsSaori Furuta
Department of Chemistry and Biochemistry, California State University at Los Angeles, 5151 State University Drive, Los Angeles, CA 90032, U S A
Biochem J 365:639-48. 2002..At copper accumulation levels higher than 60 microg/g of cellular protein, p53 is oxidized. These results suggest that p53 is vulnerable to free radical-mediated oxidation at cysteine residues...
- Metabolic activation of herbicide products by Vicia faba detected in human peripheral lymphocytes using alkaline single cell gel electrophoresisMaría Elena Calderón-Segura
Laboratorios de Citogenética y Mutagénesis Ambientales, Centro de Ciencias de la Atmosfera, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Coyoacan, 04510 Mexico DF, Mexico
Toxicol In Vitro 21:1143-54. 2007..The alkaline comet technique is a rapid and sensitive assay, to quickly evaluate DNA damage the metabolic activation of herbicide products by V. faba root in human cells in vitro...
- Cell death in human acute myelogenous leukemic cells induced by pyrrolidinedithiocarbamateL Malaguarnera
Department of Bio Medical Sciences, University of Catania, Italy
Apoptosis 8:539-45. 2003..These findings imply that normal cells are equipped with mechanisms by which they respond differently to PDTC effects with respect to leukemic cells...
- Suppression of experimental abdominal aortic aneurysms in mice by treatment with pyrrolidine dithiocarbamate, an antioxidant inhibitor of nuclear factor-kappaBFederico E Parodi
Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, One Barnes-Jewish Hospital Plaza, St. Louis, MO 63110, USA
J Vasc Surg 41:479-89. 2005..It is hoped that treatment strategies that target NF-kappaB may eventually be shown to suppress the growth of small aortic aneurysms in patients...
- Regulation of tumor necrosis factor-alpha production in the isolated rat heart stimulated by bacterial lipopolysaccharide or reactive oxygenG Russell Jennings
Department of Surgery, Mercer University School of Medicine, Macon, Georgia, USA
Am Surg 70:797-800. 2004..Forskolin almost completely blocked TNF release stimulated by LPS or ROS. These data are consistent with the notion that inhibitors of NF-kappaB block cytokine production stimulated by some agents but not others...
- In vivo suppressive effect of nuclear factor-kappaB inhibitor on neutrophilic inflammation of grafts after orthotopic liver transplantation in ratsXiao-Ping Gu
Department of Hepatobiliary Surgery, Drum Tower Hospital, Medical Department of Nanjing University, Nanjing 210008, Jiangsu Province, China
World J Gastroenterol 10:3654-8. 2004....
- Inhibition of the nuclear factor-kappaB activation with pyrrolidine dithiocarbamate attenuating inflammation and oxidative stress after experimental spinal cord trauma in ratsGiovanni La Rosa
Neurosurgical Clinic and Institute of Pharmacology, University of Messina School of Medicine, Messina, Italy
J Neurosurg Spine 1:311-21. 2004..Therefore, inhibition of NF-kappaB may represent a novel approach in the treatment of SCIs...
- Antioxidants attenuate reperfusion injury after global brain ischemia through inhibiting nuclear factor-kappa B activity in ratsWan-Hua Shen
Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, Xuzhou 221002, China
Acta Pharmacol Sin 24:1125-30. 2003..NF-kappaB activation and deactivation are controlled mainly through phosphorylation and degradation of IkappaBalpha following brain ischemia...
- Effect of pyrrolidine dithiocarbamate on hepatic vascular stress gene expression during ischemia and reperfusionChan Ho Lee
College of Pharmacy, Sungkyunkwan University, Suwon, South Korea
Eur J Pharmacol 595:100-7. 2008..In a rat model of hepatic ischemia and reperfusion, our results suggest that the hepatoprotective actions of pyrrolidine dithiocarbamate may be mediated in part through the modulation of imbalanced expression of vascular stress genes...
- [Activation of nuclear factor kappa B in newborn rats sepsis]Feng Pan
Department of Pediatrics, Daping Hospital, The Third Military Medical University, Chongqing, 400042, China
Zhonghua Er Ke Za Zhi 41:582-5. 2003..2) The anti-oxidant PDTC can inhibit NF-kappa B activity in a dose-effect fashion in newborn rats with Staphylococcus aureus sepsis...
- A protective effect of pyrrolidine dithiocarbamate in a rat model of liver cirrhosisRafael Bruck
Department of Gastroenterology, The E Wolfson Medical Center, Holon, Israel
Liver Int 24:169-76. 2004..The aim of the present study was to examine the efficacy of PDTC in a chronic rat model of thioacetamide (TAA)-induced hepatic fibrosis...
- Effects of antioxidants and nitric oxide on TNF-alpha-induced adhesion molecule expression and NF-kappaB activation in human dermal microvascular endothelial cellsMi-Zu Jiang
Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan
Life Sci 75:1159-70. 2004..These results suggest a potential therapeutic approach using antioxidant agents or nitric oxide pathway modulators in the treatment of inflammatory skin diseases...
- Pyrrolidine dithiocarbamate added to University of Wisconsin solution inhibits reperfusion injury after orthotopic liver transplantation in ratsXiao-Ping Gu
Department of Anesthesiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China
Ann Clin Lab Sci 34:187-94. 2004..A therapeutic strategy directed at inhibition of NF-kappaB activation within the transplanted liver might be effective in reducing intrahepatic neutrophilic inflammation, and be beneficial to prolonged graft storage...
- Role of caspase in CD80 expression of superantigen-stimulated monocytesFumiaki Shinohara
Department of Microbiology and Immunology, Tohoku University Graduate School of Dentistry, Aoba ku, Sendai 980 8575, Japan
Int J Mol Med 14:241-6. 2004..These results indicated that CD80 driven by NF-kappaB is regulated by the enzymatic actions of caspases, which allows monocytes to participate in massive T-cell activation...
- Interactions between angiotensin II and NF-kappaB-dependent pathways in modulating macrophage infiltration in experimental diabetic nephropathyFiona T H Lee
Danielle Alberti Memorial Centre for Diabetic Complications, Vascular Division, Baker Medical Research Institute, Melbourne 8008, Australia
J Am Soc Nephrol 15:2139-51. 2004..In the context of the known proinflammatory effects of AII, it is postulated that the renoprotection conferred by angiotensin II receptor antagonism is at least partly related to the inhibition of NF-kappaB-dependent pathways...
- Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanismHsinyu Lee
Department of Life Science and Institute of Zoology, National Taiwan University, Taipei, Taiwan 106, ROC
Am J Physiol Cell Physiol 287:C1657-66. 2004....
- A pathway involving protein kinase Cdelta up-regulates cytosolic phospholipase A(2)alpha in airway epitheliumHye Jin You
School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Republic of Korea
Biochem Biophys Res Commun 321:657-64. 2004..Our results suggest that PKCdelta and ROS lie upstream of NF-kappaB, and we conclude that a PKCdelta-ROS-NF-kappaB cascade plays a pivotal role in cPLA(2)alpha induction by PMA...
- Activation of nuclear factor-kappa B and effects of pyrrolidine dithiocarbamate on TNBS-induced rat colitisKen Chen
Department of Clinical Medicine, Guangdong College of Pharmacy, Guangzhou 510224, Guangdong Province, China
World J Gastroenterol 11:1508-14. 2005....
- Linoleic acid-induced expression of inducible nitric oxide synthase and cyclooxygenase II via p42/44 mitogen-activated protein kinase and nuclear factor-kappaB pathway in retinal pigment epithelial cellsI Mo Fang
Department of Ophthalmology, National Taiwan University Hospital, No 7, Chung Shan S Rd, Taipei, Taiwan
Exp Eye Res 85:667-77. 2007..These results may provide new insights into both mechanisms of LA action on RPE cells and pathogenesis of age-related macular degeneration...
- Evaluation of the effect of pyrrolidine dithiocarbamate in suppressing inflammation in mice with dextran sodium sulfate-induced colitisIchiro Hirata
Department of Gastroenterology, Fujita Health University, Toyoake, Aichi 470 1192, Japan
World J Gastroenterol 13:1666-71. 2007..To evaluate the effect of pyrrolidine dithio-carbamate (PDTC; an NF-kappaB inhibitor) administered at low (50 mg/kg) and high (100 mg/kg) doses in suppressing colitis in mice with dextran sodium sulfate (DSS)-induced colitis...
- Antioxidant attenuates acute lung injury after cardiopulmonary bypass in ratsLi Zhong Wang
Department of Anesthesiology, Jiaxing Women and Children s Health Hospital, 42 Jinjian Rd, Jiaxing 314000, Zhejiang Province, China
Asian Cardiovasc Thorac Ann 15:2-8. 2007..It was concluded that cardiopulmonary bypass can directly induce acute lung injury, and pyrrolidine dithiocarbamate attenuates this injury by inhibiting nuclear factor-kappaB activity...
- Increased cyclooxygenase-2 expression in hypothalamic paraventricular nucleus in rats with heart failure: role of nuclear factor kappaBYang Yu
Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Hypertension 49:511-8. 2007..By enhancing access of prostaglandin E2 to hypothalamic neurons, this mechanism may contribute to augmented sympathetic nerve activity in HF...
- N-Acetyl-L-cysteine and pyrrolidine dithiocarbamate inhibited nuclear factor-kappaB activation in alveolar macrophages by different mechanismsYa-qing Li
Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Acta Pharmacol Sin 27:339-46. 2006..NAC can inhibit the processes upstream of IKK activation induced by TNF- alpha, which results in the decline of NF-kappaB activity...
- Differential suppression of endotoxin-inducible inflammatory cytokines by nuclear factor kappa B (NFkappaB) inhibitor in rat microgliaKazuyuki Nakajima
Department of Bioinformatics, Faculty of Engineering, Soka University, Hachioji, Tokyo 192 8577, Japan
Neurosci Lett 401:199-202. 2006..Taken together, these results suggest that the induction of IL-1beta and TNFalpha in endotoxin-stimulated microglia is differentially regulated at the level of NFkappaB activation...
- Angiotensin II induces monocyte chemoattractant protein-1 expression via a nuclear factor-kappaB-dependent pathway in rat preadipocytesKyoichiro Tsuchiya
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8513, Japan
Am J Physiol Endocrinol Metab 291:E771-8. 2006..Thus the augmented MCP-1 expression by ANG II in preadipocytes may provide a new link between obesity and cardiovascular disease...
- Regulation of ALP activity by TNF-alpha on human dental pulpTatsu Okabe
Department of Endodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, Japan
J Endod 32:516-20. 2006..Smad7 expression in HDP cells was increased by TNF-alpha, but decreased by PDTC treatment. These results suggest that NF- kappaB and Smad7 play an important role in the down regulation of ALP activity by TNF-alpha on HDP cells...
- The NF-kappaB inhibitors attenuate hepatic injury in bile duct ligated ratsSavas Demirbilek
Inonu University School of Medicine, Malatya, Turkey
Pediatr Surg Int 22:655-63. 2006..These results indicate that inhibitors of NF-kappaB activity such as PDTB and sulfasalazine exert a therapeutic effect on cholestatic liver injury in rats with BDL through anti-inflammatory and antioxidant actions...
- The cumulative effect of nuclear factor-kappaB (NF-kappaB) inhibition and endothelins in early cerulein-induced acute pancreatitis in ratsJ W Długosz
Department of Gastroenterology and Internal Medicine, Medical University of Białystok, Poland
Rocz Akad Med Bialymst 50:230-6. 2005..To assess effects of NF-kappaB activation inhibitor (pyrrolidine dithiocarbamate--PDTC) alone or with endothelins (ET-1, ET-2, ET-3) in early course of cerulein-induced acute pancreatitis (AP) in rats...
- Arginine vasopressin increases iNOS-NO system activity in cardiac fibroblasts through NF-kappaB activation and its relation with myocardial fibrosisYan Hong Fan
Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, 17 Changlexi Street, Xi an 710032, PR China
Life Sci 81:327-35. 2007..NO production induced by AVP may counteract the profibrotic effects of AVP, thus the development of MF perhaps depends on the balance between profibrotic AVP and antifibrotic NO effects on MF...
- [Expression of nuclear factor-kappa B and effect of pyrrolidine dithiocarbamate in Pseudomonas aeruginosa pneumonia rat model]Wen shu Chai
Department of Infectious Disease, The First Affiliated Hospital of China Medical University, Shenyang 110001, China
Zhonghua Nei Ke Za Zhi 46:815-9. 2007..To investigate the expression of nuclear factor-kappa B (NF-kappaB) and cytokines in Pseudomonas aeruginosa (PA)-induced pneumonia of rats, and the effect of pyrrolidine dithiocarbamate (PDTC)...
- Differential effects of pyrrolidine dithiocarbamate on TNF-alpha-mediated liver injury in two different models of fulminant hepatitisJin wei Lu
Department of Toxicology, Anhui Medical University, Hefei, China
J Hepatol 48:442-52. 2008..The present study aimed to investigate the effects of PDTC on lipopolysaccharide (LPS)-induced liver injury in two different models of fulminant hepatitis...
- [Inhibition of nuclear factor kappa B attenuates multiple organ injury following ruptured abdominal aortic aneurysm: an experiment with rats]Jun Yang
Department of Surgery, First Affiliated Hospital, China Medical University, Shenyang 110001, China
Zhonghua Yi Xue Za Zhi 86:237-41. 2006..CONCLUSION: PDTC attenuates the multi-organ injury by inhibiting the expression of NF-kappaB p65, thus reducing the mRNA and protein expression of its downstream gene ICAM-1 gene...
- Nuclear factor-kappaB inhibition by pyrrolidinedithiocarbamate attenuates gastric ischemia-reperfusion injury in ratsEman El Eter
Physiology Department, Medical College and King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
Can J Physiol Pharmacol 83:483-92. 2005..PDTC protects against gastric I/R injury by an antioxidant, NF-kappaB inhibition, and by reduction of pro-apoptotic protein p53 expression, which seems to be downstream to NF-kappaB, thus promoting cell survival...
- Redox regulation of cytokine-mediated inhibition of myelin gene expression in human primary oligodendrocytesMalabendu Jana
Section of Neuroscience, Department of Oral Biology, University of Nebraska Medical Center, Lincoln, NE 68583, USA
Free Radic Biol Med 39:823-31. 2005..Taken together, these studies suggest that proinflammatory cytokines inhibit the expression of myelin genes in human primary oligodendrocytes through the alteration of cellular redox...
- N-acetylcysteine inhibits induction of nitric oxide synthase in 3T3-L1 adipocytesShunsuke Araki
Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan
J UOEH 29:417-29. 2007..These results suggest that NAC regulates iNOS expression and NO production in adipocytes through the modulating activation of NF-kappa B...
- Distinct inhibitory mechanisms of isoquercitrin gallate and its aglycone on zymosan-induced peroxynitrite production in macrophagesByung Hak Kim
College of Pharmacy and Research Center for Bioresource and Health, Chungbuk National University, Cheongju 361 763, Republic of Korea
Nitric Oxide 17:134-42. 2007..Taken together, Q-32 and quercetin could provide invaluable tools to investigate zymosan-induced oxidative stress with distinct antioxidant mechanisms...
- Upregulation of cyclooxygenase-2 by motorcycle exhaust particulate-induced reactive oxygen species enhances rat vascular smooth muscle cell proliferationHuei Ping Tzeng
Institute of Toxicology and Department of Orthopaedics, College of Medicine, National Taiwan University, Taipei, Taiwan
Chem Res Toxicol 20:1170-6. 2007..Taken together, these findings suggest that MEPE may contribute to the enhancement of the pathogenesis of cardiovascular diseases by augmenting proliferation of VSMCs through a ROS-regulated ERK1/2-activated COX-2 signaling pathway...
- [The expression of nuclear factor-kappa B in lipopolysaccharide-induced keratitis of rats and the effect of pyrrolidine dithiocarbamate on its expression]Xin yi Wu
Department of Ophthalmology, Qilu Hospital, Shandong University, Jinan 250012, China
Zhonghua Yan Ke Za Zhi 42:699-703. 2006..To investigate the expression of nuclear factor-kappa B (NF-kappaB) and cytokines in lipopolysaccharide (LPS)-induced keratitis of rats, and the effect of pyrrolidine dithiocarbamate (PDTC) on its expression...
- Pyrrolidine dithiocarbamate reduces the severity of cerulein-induced murine acute pancreatitisIoannis Virlos
Hepatobiliary Unit, Department of Surgery, Manchester Royal Infirmary, Manchester, United Kingdom
Shock 20:544-50. 2003....
- Glucocorticoids induced the production and gene expression of IL-1alpha through AP-1 and partially NF-kappaB activation in murine epidermal cellsSherif Awad
Department of Dermatology and Immunodermatology, Graduate School, Tokyo Medical and Dental University, Japan
J Med Dent Sci 49:27-35. 2002..These data indicated that lower concentration of glucocorticoids induced the augmentation of IL-1alpha production from keratinocytes mediated through the AP-1 pathway and partially through NF-kappaB pathway...
- Endotoxin stress-response in cardiomyocytes: NF-kappaB activation and tumor necrosis factor-alpha expressionGary Wright
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Am J Physiol Heart Circ Physiol 282:H872-9. 2002..Taken together, these results reveal that NF-kappaB is not only involved in cytokine production but also may be linked to other pathways that subserve a constitutive, protective mechanism for the heart cell...
- Acid exposure stimulates the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells: effects on platelet-activating factor receptor expressionS Ishizuka
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
Am J Respir Cell Mol Biol 24:459-68. 2001..Increased adherence of S. pneumoniae may be one of the reasons why pneumonia develops after gastric juice aspiration...
- Induction of MMP-9 in normal human bronchial epithelial cells by TNF-alpha via NF-kappa B-mediated pathwayA Hozumi
First Department of Internal Medicine, Kobe University School of Medicine, Kobe 650-0017, Japan
Am J Physiol Lung Cell Mol Physiol 281:L1444-52. 2001..These results suggest that TNF-alpha induces the expression of MMP-9 in human bronchial epithelial cells and that this induction is mediated via the NF-kappa B-mediated pathway...
- Surfactant protein D regulates NF-kappa B and matrix metalloproteinase production in alveolar macrophages via oxidant-sensitive pathwaysM Yoshida
Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Immunol 166:7514-9. 2001..Oxidant production and reactive oxygen species were increased in lungs of SP-D(-/-) mice, in turn activating NF-kappaB and MMP expression. SP-D plays an unexpected inhibitory role in the regulation of NF-kappaB in AMs...
- Transcription factor decoy oligodeoxynucleotides to nuclear factor-kappaB inhibit reverse passive Arthus reaction in ratA Ianaro
Department of Experimental Pharmacology, University of Naples Federico II, Via Domenico Montesano, 49, 80131 Naples, Italy
Naunyn Schmiedebergs Arch Pharmacol 364:422-9. 2001..Our results indicate that decoy ODN, acting as an in vivo competitor for the transcription factor's ability to bind to cognate recognition sequence, may represent a novel strategy to modulate immune reactions...
- Role of nuclear factor-kappaB in a rat model of vascular injuryA Ialenti
Department of Experimental Pharmacology, University of Naples Federico II, Italy
Naunyn Schmiedebergs Arch Pharmacol 364:343-50. 2001..These results indicate that prevention of NF-kappaB activation may lead to the inhibition of neointima formation and suggest that antioxidant agents may have therapeutic relevance for the prevention of human restenosis...
- Endothelial apoptosis induced by oxidative stress through activation of NF-kappaB: antiapoptotic effect of antioxidant agents on endothelial cellsM Aoki
Department of Geriatric Medicine, Osaka University Medical School, Osaka, Japan
Hypertension 38:48-55. 2001..Oxidative stress may play an important role in endothelial apoptosis mediated by hypoxia, through the activation of NF-kappaB...
- Specific pancreatic enzymes activate macrophages to produce tumor necrosis factor-alpha: role of nuclear factor kappa B and inhibitory kappa B proteinsC Jaffray
Department of Surgery, University of South Florida, Tampa, FL 33601, USA
J Gastrointest Surg 4:370-7; discussion 377-8. 2000..This process is dependent on I kappa B-beta degradation and NF- kappa B activation, suggesting that these enzymes trigger this second messenger system through specific membrane-bound receptors...
- Effects of idoxifene and estradiol on NF-kappaB activation in cultured rat hepatocytes undergoing oxidative stressT Omoya
Second Department of Internal Medicine, Tokushima University School of Medicine, Tokushima, and General Laboratory for Medical Research, Tokushima University School of Medicine, Tokushima, Japan
Liver 21:183-91. 2001..CONCLUSIONS: These findings suggest that idoxifene and estradiol function as antioxidants and protect hepatocytes from inflammatory cell injury...
- Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibitionAnna Csiszar
Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 291:H1694-9. 2006..We propose that these anti-inflammatory actions of resveratrol are responsible, at least in part, for its cardioprotective effects...
- LPS induction of I kappa B-alpha degradation and iNOS expression in a skin dendritic cell line is prevented by the janus kinase 2 inhibitor, Tyrphostin b42M T Cruz
, Universidade de Coimbra, 3000 Coimbra, Portugal
Nitric Oxide 5:53-61. 2001..These results indicate that the JAK family of protein kinases and the transcription factor NF-kappa B are involved in the induction of iNOS protein expression in FSDC stimulated with LPS...
- Hyperoxia upregulates the NO pathway in alveolar macrophages in vitro: role of AP-1 and NF-kappaBS Pepperl
Institute for Surgical Research, Klinikum Grosshadern, University of Munich, D-81366 Munich, Germany
Am J Physiol Lung Cell Mol Physiol 280:L905-13. 2001..The results presented here indicate that hyperoxia can upregulate the NO pathway in stimulated AMs through increased production of intracellular ROS and activation of NF-kappaB and AP-1...
- Peroxynitrite mediates cytokine-induced IL-8 gene expression and production by human leukocytesC Zouki
Research Center, Maisonneuve-Rosemont Hospital, , H1T 2M4, Canada
J Leukoc Biol 69:815-24. 2001..These results indicate that ONOO(-) formation may underlie the action of cytokines towards IL-8 gene expression in human leukocytes...
- Pyrrolidine dithiocarbamate protects against thioacetamide-induced fulminant hepatic failure in ratsRafael Bruck
Department of Gastroenterology, E Wolfson Medical Center, 58100, Holon, Israel
J Hepatol 36:370-7. 2002....
- Inhibitory effects of pyrrolidine dithiocarbamate on endotoxin-induced uveitis in Lewis ratsKouichi Ohta
Department of Ophthalmology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
Invest Ophthalmol Vis Sci 43:744-50. 2002..To determine the effect of pyrrolidine dithiocarbamate (PDTC), an antioxidant nuclear factor (NF)-kappaB inhibitor, on the ocular inflammation induced by lipopolysaccharide (LPS)...
- CD40 ligand (CD40L) does not stimulate proliferation of vascular smooth muscle cellsAlexander Hermann
, , Germany
Eur J Cell Biol 81:213-21. 2002..Finally, sCD40L did not induce SMC migration. From these data it is concluded that CD40L activates mitogenic signalling and DNA synthesis but does not contribute to proliferation or migration of vascular SMC...
- Effects of TNFalpha on expression of ICAM-1 in human airway epithelial cells in vitro: oxidant-mediated pathways and transcription factorsThomas M Krunkosky
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
Free Radic Biol Med 35:1158-67. 2003....
- Phosphoinositide 3-kinase activity leads to silica-induced NF-kappaB activation through interacting with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaBJihee Lee Kang
Department of Physiology, College of Medicine, Division of Cell Biology, Ewha Medical Research Center, Ewha Womans University, Seoul, Korea
Mol Cell Biochem 248:17-24. 2003..Our data suggest that p85 and p110 subunits of PI3-kinase play a role in NF-kappaB activation through interaction with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB...
- Hyperoxia elicits myocardial protection through a nuclear factor kappaB-dependent mechanism in the rat heartPeeter Tähepõld
Crafoord Laboratory of Experimental Surgery, Karolinska Hospital, Stockholm, Sweden
J Thorac Cardiovasc Surg 125:650-60. 2003..In the present study we investigated whether the cardioprotective effects of hyperoxia were dependent on the redox-sensitive transcription factor nuclear factor kappaB...
- NF-kappaB activation is detrimental in arginine-induced acute pancreatitisZoltan Rakonczay
First Department of Medicine, University of Szeged, Szeged, Hungary
Free Radic Biol Med 34:696-709. 2003..The increased levels of HSPs most probably act to limit the severity of the disease...
- Role of renin-angiotensin system and nuclear factor-kappaB in the obstructed kidney of rats with unilateral ureteral obstructionTatsuya Nakatani
Department of Urology, Osaka City University, Japan
Jpn J Pharmacol 90:361-4. 2002..These results suggest that the beneficial effects of angiotensin blockade are mediated by the inhibition of oxidative stress and subsequent NF-kappaB activation in obstructive nephropathy...
- Ethanol induces rapid lipid peroxidation and activation of nuclear factor-kappa B in cerebral vascular smooth muscle: relation to alcohol-induced brain injury in ratsBurton M Altura
Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA
Neurosci Lett 325:95-8. 2002....
- Nuclear factor-kappa B p65 mediates the assembly and activation of the TNF-responsive element of the murine monocyte chemoattractant-1 geneD Ping
Department of Microbiology and Immunology, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA
J Immunol 162:727-34. 1999..This study illustrates the crucial role for NF-kappa B p65 in the induction of the MCP-1 gene by TNF and in the assembly of a NF-kappa B dependent enhancer in vivo...
- Literature review--efficacy of various disinfectants against Legionella in water systemsB R Kim
Ford Research Laboratory, Dearborn, MI 48121, USA
Water Res 36:4433-44. 2002..hydantoins], ozone, and hydrogen peroxide), non-oxidizing agents (heterocyclic ketones, guanidines, thiocarbamates, aldehydes, amines, thiocyanates, organo-tin compounds, halogenated amides, and halogenated glycols), and UV ..
- Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesisP Talalay
Department of Pharmacology and Molecular Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205
Proc Natl Acad Sci U S A 85:8261-5. 1988..polycyclic aromatics, flavonoids, coumarins, cinnamates, indoles, isothiocyanates, 1,2-dithiol-3-thiones, and thiocarbamates. The only known common property of these anticarcinogens is their ability to elevate in animal cells the ..
- Risk assessment of representative and priority pesticides, in surface water of the Alqueva reservoir (South of Portugal) using on-line solid phase extraction-liquid chromatography-tandem mass spectrometryP Palma
Departamento de Ciências do Ambiente, Escola Superior Agrária de Beja, Apartado 6158, 7801 908 Beja, Portugal
Environ Int 35:545-51. 2009..The pesticides belonging to the classes of phenylureas, triazines, chloroacetanilides, organophosphorous and thiocarbamates were analysed by on-line solid phase extraction-liquid chromatography-tandem mass spectrometry...
- Promotion of organophosphate induced delayed polyneuropathy by certain esterase inhibitorsMarcello Lotti
Universita degli Studi di Padova, Dipartimento di Medicina Ambientale e Sanità Pubblica, Via Giustiniani 2, 35128 Padua, Italy
Toxicology 181:245-8. 2002..Other OPs, sulphonyl halides, carbamates, thiocarbamates and phosphinates do not cause axonopathy but elicit or intensify the clinical expression of OPIDP when given ..
- Analysis of 17 polar to semi-polar pesticides in the Ebro river delta during the main growing season of rice by automated on-line solid-phase extraction-liquid chromatography-tandem mass spectrometryMarina Kuster
Institute of Chemical and Environmental Research of Barcelona IIQAB, Spanish Council for Scientific Research CSIC, Jordi Girona 18 26, 08034 Barcelona, Spain
Talanta 75:390-401. 2008..included organophosphates, triazines, phenylureas, anilides, chloroacetanilides, acidic herbicides and thiocarbamates. Detection limits achieved were below 5 ng/L for all compounds except metolachlor (12 ng/L), alachlor (17 ng/L)..
- Structure-based design, parallel synthesis, structure-activity relationship, and molecular modeling studies of thiocarbamates, new potent non-nucleoside HIV-1 reverse transcriptase inhibitor isosteres of phenethylthiazolylthiourea derivativesAngelo Ranise
Dipartimento di Scienze Farmaceutiche, Universita di Genova, Viale Benedetto XV 3, I 16132 Genova, Italy
J Med Chem 48:3858-73. 2005..synthetic strategy, and structure-activity relationship (SAR) studies that led to the identification of thiocarbamates (TCs), a novel class of non-nucleoside reverse transcriptase inhibitors (NNRTIs), isosteres of ..
- An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm populationT E Arbuckle
Bureau of Reproductive and Child Health, Population and Public Health Branch, Health Canada, Ottawa, Ontario, Canada
Environ Health Perspect 109:851-7. 2001..4; 95% CI, 1.1-1.9). For late abortions, preconception exposure to glyphosate (OR = 1.7; 95% CI, 1.0-2.9), thiocarbamates (OR = 1.8; 95% CI, 1.1-3.0), and the miscellaneous class of pesticides (OR = 1.5; 95% CI, 1.0-2...
- In vitro and in vivo activities of piritetrate (M-732), a new antidermatophytic thiocarbamateK Iwata
Department of Microbiology, Meiji College of Pharmacy, Tokyo, Japan
Antimicrob Agents Chemother 33:2118-25. 1989Piritetrate (M-732), a new topical antifungal agent belonging chemically to the thiocarbamates, was demonstrated to possess a potent selective antidermatophytic activity...
- Influence of water filtration on the determination of a wide range of dissolved contaminants at parts-per-trillion levelsAnna Gómez-Gutiérrez
Department of Environmental Chemistry I I Q A B C S I C, Jordi Girona 18 26, E 08034 Barcelona, Spain
Anal Chim Acta 583:202-9. 2007..levels (ng L(-1)), including PAHs, PCBs, organochlorine and organophosphorus pesticides, triazines, thiocarbamates, pyrethroids, phosphate esters and caffeine...
- Promoters and promotion of axonopathiesA Moretto
Istituto di Medicina del Lavoro, Universita degli Studi di Padova, Via Giustiniani 2, 35128, Padova, Italy
Toxicol Lett 112:17-21. 2000..by certain esterase inhibitors (organophosphates, organophosphinates, sulfonyl halides, carbamates and thiocarbamates) of the clinical and morphological expression of toxic and traumatic axonopathies...
- Theoretical prediction of the photoinduced chemiluminescence of pesticidesI Sahuquillo Ricart
Departamento de Quimica, Bioquimica y Biologia Molecular, Universidad Cardenal Herrera CEU, Moncada, Valencia, Spain
Talanta 72:378-86. 2007..members of the most important families of pesticides were tested (oxime carbamates, sulfonylcarbamates, thiocarbamates, 1,3,5-triazines, organophosphorous, hydroxybenzonitrile, sulfonylureas, phosphonic acid derivatives, ..
- Direct organocatalytic asymmetric aldol reaction of alpha-isothiocyanato imides to alpha-ketoesters under low ligand loading: a doubly stereocontrolled approach to cyclic thiocarbamates bearing chiral quaternary stereocentersXianxing Jiang
State Key Laboratory of Applied Organic Chemistry, Institute of Biochemistry and Molecular Biology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou, 730000, China
Org Lett 12:1544-7. 2010..with alpha-ketoesters by using rosin-derived tertiary amine-thiourea under low ligand loading to form cyclic thiocarbamates bearing quaternary stereogenic centers with high levels of enantio- and diastereoselectivity (up to 99% ee, ..
- Solid-phase microextraction in pesticide residue analysisJ Beltran
Analytical Chemistry, Department of Experimental Sciences, University Jaume I, Castello, Spain
J Chromatogr A 885:389-404. 2000..applications divided according to the pesticide families (organochlorine, organophosphorus, triazines, thiocarbamates, substituted uracils, urea derivatives and dinitroanilines among others) and the sample matrices analysed ..
- Determination of cereal herbicide residues in environmental samples by gas chromatographyJ L Tadeo
, CIT-INIA, Madrid, Spain
J Chromatogr A 754:347-65. 1996..e., phenoxyacids, benzonitriles, ureas, triazines, dinitroanilines, chloroacetamides and thiocarbamates, are considered...
- The thiocarbamate-inducible Rhodococcus enzyme ThcF as a member of the family of alpha/beta hydrolases with haloperoxidative side activityRené De Mot
Department of Applied Plant Sciences, Catholic University of Leuven, Kasteelpark Arenberg 20, B 3001 Heverlee, Belgium
FEMS Microbiol Lett 224:197-203. 2003..Sulfoxidation of thiocarbamates was demonstrated but probably represents a side activity due to peroxoacid generation by the enzyme...
- A unique approach to the concise synthesis of highly optically active spirooxazolines and the discovery of a more potent oxindole-type phytoalexin analogueXianxing Jiang
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, China
J Am Chem Soc 132:15328-33. 2010..active spiro[oxazoline-3,3'-oxindole]s through the organocatalyzed asymmetric synthesis of spirocyclic thiocarbamates via an aldol reaction...
- Thiolo-, thiono- and dithiocarbonate and thiocarbamate derivatives of demethylpenclomedine as novel anticancer agentsRobert F Struck
Southern Research Institute, 2000 Ninth Avenue South, P O Box 55305, Birmingham, Alabama 35255 5305, USA
Cancer Chemother Pharmacol 57:180-4. 2006....
- Proepithelin stimulates growth plate chondrogenesis via nuclear factor-kappaB-p65-dependent mechanismsShufang Wu
First Affiliated Hospital of Medical School of Xi an Jiaotong University, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Medical School of Xi an Jiaotong University, Xi an, 710061 China
J Biol Chem 286:24057-67. 2011..These results support the hypothesis that the induction of NF-κB activity of in growth plate chondrocytes is critical in proepithelin-mediated growth plate chondrogenesis and longitudinal bone growth...
- Synthetic routes to mixed-ligand cobalt(III) dithiocarbamato complexes containing imidazole, amine and pyridine donors and the X-ray crystal structure of a cobalt(III) bis(dithiocarbamato) histamine complexMichael C Hodgson
Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand
J Inorg Biochem 102:789-97. 2008..All new complexes were fully characterised, and the X-ray crystal structure of the histamine complex [Co(Me(2)dtc)(2)(hist)]ClO(4) is also reported...
- Insulin-induced activation of hypoxia-inducible factor-1 requires generation of reactive oxygen species by NADPH oxidaseSudipta Biswas
Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110 067, India
Am J Physiol Heart Circ Physiol 292:H758-66. 2007..Overall, our data provide strong evidence for the essential role of NADPH oxidase-generated ROS in insulin-stimulated activation of HIF-1...
Research Grants104 found, 100 shown here
- MOLECULAR TARGETS OF NITRIC OXIDE IN CARDIAC TRANSPLANTSGALEN PIEPER; Fiscal Year: 2004..These studies will provide a novel mechanism to explain the pathogenesis of dyskinesis and graft failure during cardiac transplant rejection. ..
- iNOS Posttranslational Regulation in Cardiac RejectionGALEN PIEPER; Fiscal Year: 2007..A better understanding of this molecular process may lead to better strategies to prevent injury cardiac cells in these patients. ..
- iNOS Posttranslational Regulation in Cardiac RejectionGALEN PIEPER; Fiscal Year: 2009..A better understanding of this molecular process may lead to better strategies to prevent injury cardiac cells in these patients. ..
- Lung carcinogenesis: Chemoprevention by Indole-3-carbinolFekadu Kassie; Fiscal Year: 2009..Proving the hypothesis that indole-3-carbinol (I3C) inhibits lung tumorigenesis in A/J mouse model provides a solid platform for clinical trials of I3C as a chemopreventive agent against lung cancer. ..
- Tobacco CarcinogenesisStephen Hecht; Fiscal Year: 2005..Steven Tannenbaum (MIT), Dr. Jack Henningfield (Johns Hopkins and Pinney Associates), Drs. Jeffrey Seeman and Anthony Tricker (Philip Morris), and Dr. John Lauterbach (an independent consultant, formerly with Brown and Williamson). ..
- DETECTION OF DNA ADDUCTS OF PULMONARY CARCINOGENS BY AMSStephen Hecht; Fiscal Year: 2004..abstract not provided ..
- DNA Adducts of the Carcinogen AcetaldehydeStephen Hecht; Fiscal Year: 2006..The results of the research proposed here will provide critical data, which will be the framework for testing our hypothesis that acetaldehyde is a human carcinogen. ..
- Benzo(a) pyrene Metabolism: Phenotyping and GenotypingStephen Hecht; Fiscal Year: 2005....
- Lung carcinogenesis: Chemoprevention by Indole-3-carbinolFekadu Kassie; Fiscal Year: 2010..Proving the hypothesis that indole-3-carbinol (I3C) inhibits lung tumorigenesis in A/J mouse model provides a solid platform for clinical trials of I3C as a chemopreventive agent against lung cancer. ..
- DNA Adducts of the Carcinogen AcetaldehydeStephen S Hecht; Fiscal Year: 2010..These studies will provide critical data on the occurrence and biological significance of acetaldehyde DNA adducts and their possible role in human cancer. ..
- CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTSStephen Hecht; Fiscal Year: 2004..This grant proposal will replace the corresponding portion of the Principal Investigator's Outstanding Investigator Grant, as the latter program is being phased out by the National Cancer Institute. ..
- CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTSStephen S Hecht; Fiscal Year: 2010..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
- CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTSStephen Hecht; Fiscal Year: 2009..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
- Benzo[a]pyrene metabolism: phenotyping and genotypingStephen Hecht; Fiscal Year: 2007..The results of this study will greatly improve our understanding of PAH metabolism in humans and could ultimately lead to a predictive algorithm for lung cancer risk in smokers. Such information is vital for lung cancer prevention. ..
- DNA Adducts of the Carcinogen AcetaldehydeStephen Hecht; Fiscal Year: 2007..These studies will provide critical data on the occurrence and biological significance of acetaldehyde DNA adducts and their possible role in human cancer. ..
- CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTSStephen Hecht; Fiscal Year: 2007..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
- Lung Cancer Chemoprevention: Isothiocyanates, inositolStephen Hecht; Fiscal Year: 2007..abstract_text> ..
- Metabolism of Carcinogenic Tobacco-Specific NitrosaminesStephen Hecht; Fiscal Year: 2007....
- Benzo[a]pyrene metabolism: phenotyping and genotypingStephen S Hecht; Fiscal Year: 2010..The results of this study will greatly improve our understanding of PAH metabolism in humans and could ultimately lead to a predictive algorithm for lung cancer risk in smokers. Such information is vital for lung cancer prevention. ..
- MECHANISM(S) OF CHEMICAL LEUKEMOGENESISRichard Irons; Fiscal Year: 1993....
- MECHANISM(S) OF CHEMICAL LEUKEMOGENESISRichard Irons; Fiscal Year: 2002..A. in specific sub-populations of CD34+ human BM cells. Finally, patterns of gene expression will be correlated with genotype, phenotype and functional clonogenic response in BM cells obtained from patients with MDS or evolving sAML. ..
- METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINESStephen Hecht; Fiscal Year: 2003..abstract_text> ..
- Mechanisms of methyl dithiocarbamate immunotoxicityStephen B Pruett; Fiscal Year: 2010..It is also expected that the detailed study of three important mechanisms of action, which will be examined in each aim, can be generalized to other situations or toxicants that alter these parameters. ..
- GASTROINTESTINAL PEPTIDE SIGNALING THROUGH PKC/PKDJUAN ENRIQUE ROZENGURT; Fiscal Year: 2010....
- GI PEPTIDE SIGNALING THROUGH TYROSINE PHOSPHORYLATIONJUAN ENRIQUE ROZENGURT; Fiscal Year: 2010....
- MECHANISMS OF IMMUNOSUPPRESSION BY ONE DOSE OF ETHANOLStephen Pruett; Fiscal Year: 2007..abstract_text> ..
- Mechanisms of methyl dithiocarbamate immunotoxicityStephen B Pruett; Fiscal Year: 2010..It is also expected that the detailed study of three important mechanisms of action, which will be examined in each aim, can be generalized to other situations or toxicants that alter these parameters. ..
- GASTROINTESTINAL PEPTIDE SIGNALING THROUGH PKC/PKDJUAN ENRIQUE ROZENGURT; Fiscal Year: 2010....
- GASTROINTESTINAL PEPTIDE SIGNALING THROUGH PKC/PKDJUAN ROZENGURT; Fiscal Year: 2007..abstract_text> ..
- GASTROINTESTINAL PEPTIDE SIGNALING THROUGH PKC/PKDJUAN ROZENGURT; Fiscal Year: 2002....
- Mechanisms of Immunotoxcity of Chemical StressorsStephen Pruett; Fiscal Year: 2005....
- MECHANISMS OF IMMUNOSUPPRESSION BY ONE DOSE OF ETHANOLStephen Pruett; Fiscal Year: 2003..These results have implications for human health, because even moderate EtOH consumption increased the incidence of cancer and many persons with EtOH-associated cancers have decreased NK cell function. ..
- GI PEPTIDE SIGNALING THROUGH TYROSINE PHOSPHORYLATIONJUAN ROZENGURT; Fiscal Year: 2004..2b) Determine the role of EGFR transactivation in signaling GI peptide-mediated mitogenesis. 2c) Characterize GPCR-induced transactivation of EGFR in IEC-6 cells. ..
- GASTROINTESTINAL PEPTIDE SIGNALING THROUGH PKC/PKDJUAN ROZENGURT; Fiscal Year: 2009....
- The Mechanism of Lung Chemoprevention Mediated by ITCsYang Ming Yang; Fiscal Year: 2005..In this project, our primary goal is to examine the chemopreventive effects of ITCs in mitotic checkpoint deficient mice as well as the effects of ITCs on mitotic checkpoint regulation. ..