methazolamide

Summary

Summary: A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.

Top Publications

  1. ncbi Non-catalytic role of carbonic anhydrase in rat intestinal absorption
    Alan N Charney
    Nephrology Section, VA Medical Center, New York University School of Medicine, 423 East 23rd Street, New York, NY 10010, USA
    Biochim Biophys Acta 1573:141-8. 2002
  2. doi Preparation and evaluation of in situ gelling ophthalmic drug delivery system for methazolamide
    Yong Qian
    School of Pharmacy, Nanjing Medical University, Nanjing, PR China
    Drug Dev Ind Pharm 36:1340-7. 2010
  3. pmc Methazolamide and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury
    Xin Wang
    Department of Neurosurgery, Neuroapoptosis Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Stroke 40:1877-85. 2009
  4. ncbi Stevens-Johnson syndrome induced by methazolamide treatment
    S Shirato
    Department of Ophthalmology, University of Tokyo School of Medicine, Japan
    Arch Ophthalmol 115:550-3. 1997
  5. ncbi Methazolamide calcium phosphate nanoparticles in an ocular delivery system
    Rui Chen
    Department of Pharmaceutics, Nanjing Medical University, China
    Yakugaku Zasshi 130:419-24. 2010
  6. ncbi Effect of methazolamide on chronic macular edema in patients with retinitis pigmentosa
    G A Fishman
    Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago College of Medicine 60612
    Ophthalmology 101:687-93. 1994
  7. ncbi Inhibition of hypoxia-induced calcium responses in pulmonary arterial smooth muscle by acetazolamide is independent of carbonic anhydrase inhibition
    Larissa A Shimoda
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1002-12. 2007
  8. doi A potential new therapeutic system for glaucoma: solid lipid nanoparticles containing methazolamide
    Rui Li
    School of Pharmacy, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, People s Republic of China
    J Microencapsul 28:134-41. 2011
  9. pmc Treat ankylosing spondylitis with methazolamide
    Xiaotian Chang
    National Laboratory for Bio Drugs of Ministry of Health, Provincial Laboratory for Modern Medicine and Technology of Shandong, Research Center for Medicinal Biotechnology of Shandong Academy of Medical Sciences, Jingshi Road 18877, Jinan, Shandong 250062, P R China
    Int J Med Sci 8:413-9. 2011
  10. doi Bilateral transient myopia, angle-closure glaucoma, and choroidal detachment induced by methazolamide
    Soon Jae Kwon
    Department of Ophthalmology, School of Medicine, Kyungpook National University, 50 Samduk dong 2 ga, Jung Gu, Daegu 700721, Korea
    Jpn J Ophthalmol 56:515-7. 2012

Scientific Experts

Detail Information

Publications111 found, 100 shown here

  1. ncbi Non-catalytic role of carbonic anhydrase in rat intestinal absorption
    Alan N Charney
    Nephrology Section, VA Medical Center, New York University School of Medicine, 423 East 23rd Street, New York, NY 10010, USA
    Biochim Biophys Acta 1573:141-8. 2002
    ..Measurements were made in the presence and absence of 0.1 mM methazolamide, a membrane-permeant CA inhibitor. Ringer pH reduction from 7.6 to 7...
  2. doi Preparation and evaluation of in situ gelling ophthalmic drug delivery system for methazolamide
    Yong Qian
    School of Pharmacy, Nanjing Medical University, Nanjing, PR China
    Drug Dev Ind Pharm 36:1340-7. 2010
    In this study, a thermosensitive in situ gelling vehicle was prepared to increase the precorneal resident time and the bioavailability of methazolamide (MTA).
  3. pmc Methazolamide and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury
    Xin Wang
    Department of Neurosurgery, Neuroapoptosis Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Stroke 40:1877-85. 2009
    ..We demonstrate that methazolamide and melatonin are protective in cellular and in vivo models of neuronal hypoxia.
  4. ncbi Stevens-Johnson syndrome induced by methazolamide treatment
    S Shirato
    Department of Ophthalmology, University of Tokyo School of Medicine, Japan
    Arch Ophthalmol 115:550-3. 1997
    Four cases of Stevens-Johnson syndrome considered to be induced by methazolamide were reported. In all of the cases, the first signs of Stevens-Johnson syndrome (i.e...
  5. ncbi Methazolamide calcium phosphate nanoparticles in an ocular delivery system
    Rui Chen
    Department of Pharmaceutics, Nanjing Medical University, China
    Yakugaku Zasshi 130:419-24. 2010
    A new system for the local delivery of methazolamide to the eye has been developed based on calcium phosphate (CaP) nanoparticles...
  6. ncbi Effect of methazolamide on chronic macular edema in patients with retinitis pigmentosa
    G A Fishman
    Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago College of Medicine 60612
    Ophthalmology 101:687-93. 1994
    To determine the effectiveness of methazolamide for improving visual acuity and macular edema in patients with retinitis pigmentosa.
  7. ncbi Inhibition of hypoxia-induced calcium responses in pulmonary arterial smooth muscle by acetazolamide is independent of carbonic anhydrase inhibition
    Larissa A Shimoda
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1002-12. 2007
    ..These results suggest that AZ attenuates HPV by selectively inhibiting hypoxia-induced Ca2+ responses via a mechanism independent of CA inhibition, changes in pH(i), or membrane potential...
  8. doi A potential new therapeutic system for glaucoma: solid lipid nanoparticles containing methazolamide
    Rui Li
    School of Pharmacy, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, People s Republic of China
    J Microencapsul 28:134-41. 2011
    b>Methazolamide (MTA) is an antiglaucoma drug; however, there are many side effects of its systemic administration with insufficient ocular therapeutic concentrations...
  9. pmc Treat ankylosing spondylitis with methazolamide
    Xiaotian Chang
    National Laboratory for Bio Drugs of Ministry of Health, Provincial Laboratory for Modern Medicine and Technology of Shandong, Research Center for Medicinal Biotechnology of Shandong Academy of Medical Sciences, Jingshi Road 18877, Jinan, Shandong 250062, P R China
    Int J Med Sci 8:413-9. 2011
    ..This study aimed to evaluate the effectiveness and safety of methazolamide, an anti-carbonic anhydrase drug, for treating patients with AS.
  10. doi Bilateral transient myopia, angle-closure glaucoma, and choroidal detachment induced by methazolamide
    Soon Jae Kwon
    Department of Ophthalmology, School of Medicine, Kyungpook National University, 50 Samduk dong 2 ga, Jung Gu, Daegu 700721, Korea
    Jpn J Ophthalmol 56:515-7. 2012
    We report the case of a patient with acute bilateral transient myopia, secondary angle-closure glaucoma, and choroidal detachment associated with oral administration of methazolamide.
  11. ncbi HLA-B*5901 is strongly associated with methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis
    Sae Hoon Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Pharmacogenomics 11:879-84. 2010
    The carbonic anhydrase inhibitor methazolamide infrequently causes Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). An association between these diseases and the HLA-B59 serotype has been suggested in case reports...
  12. ncbi Effects of low-dose methazolamide on the control of breathing in cats
    J H L Bijl
    Department of Anesthesiology Leiden University Medical Center Leiden, The Netherlands
    Adv Exp Med Biol 580:257-62; discussion 351-9. 2006
  13. ncbi Double-blind controlled study of methazolamide in the treatment of essential tremor
    K Busenbark
    Department of Neurology, University of Kansas Medical Center, Kansas City 66160 7314
    Neurology 43:1045-7. 1993
    We studied the effect of the carbonic anhydrase inhibitor methazolamide in 25 patients with essential tremor (ET) in a double-blind, placebo-controlled trial...
  14. ncbi Methazolamide 1% in cyclodextrin solution lowers IOP in human ocular hypertension
    E Gudmundsdottir
    Departments of Ophthalmology and Pharmacy, University of Iceland, Reykjavik
    Invest Ophthalmol Vis Sci 41:3552-4. 2000
    To formulate aqueous eye drops containing methazolamide 1% in cyclodextrin solution and to evaluate their effect on intraocular pressure (IOP) in a double-blind randomized trial in humans...
  15. ncbi Carbonic anhydrase inhibitors are antiarthritic in the rat
    J C Nolan
    Department of Pharmacology, A H Robins Co, Richmond, VA 23220
    Pharmacol Res 24:377-83. 1991
    ..Acetazolamide, ethoxzolamide, methazolamide, and dichlorphenamide reduced paw oedema and attenuated the deterioration of the joints of rats with adjuvant ..
  16. ncbi Gramicidin-perforated patch analysis on HCO3- secretion through a forskolin-activated anion channel in rat parotid intralobular duct cells
    C Hirono
    Department of Oral Physiology, Hiroshima University School of Dentistry, Hiroshima 734 8553, Japan
    J Membr Biol 180:11-9. 2001
    ..The anion current was markedly suppressed by addition of 1 mM methazolamide, a carbonic anhydrase inhibitor, and removal of external HCO3-...
  17. ncbi Treatment of essential tremor with methazolamide
    M D Muenter
    Lee Silverman Center for Parkinson s Disease and Movement Disorders, Mayo Clinic Scottsdale, AZ 85259
    Mayo Clin Proc 66:991-7. 1991
    We treated 28 patients (16 women and 12 men) who had essential tremor with methazolamide. Their median age was 69 years (range, 34 to 89 years), and the median duration of tremor was 16 years (range, less than 1 to 69 years)...
  18. ncbi Acid-base effects on electrolyte transport in CA II-deficient mouse colon
    D S Goldfarb
    Nephrology Section, Veterans Affairs Medical Center and New York University School of Medicine, New York, New York 10010, USA
    Am J Physiol Gastrointest Liver Physiol 278:G409-15. 2000
    ..Membrane-permeant methazolamide, but not impermeant benzolamide, at 0.1 mM prevented the effects of pH...
  19. ncbi Topical inhibition of nasal carbonic anhydrase affects the CO2 detection threshold in rats
    Katheryn E Ferris
    Neuroscience Program, Allegheny College, Meadville, PA 16335, USA
    Chem Senses 32:263-71. 2007
    ..2) to determine the rats' CO(2) detection thresholds before and after nasal perfusion of mammalian Ringers or methazolamide, a CA inhibitor...
  20. ncbi Carbonic anhydrases and mucosal vanilloid receptors help mediate the hyperemic response to luminal CO2 in rat duodenum
    Yasutada Akiba
    Department of Medicine, School of Medicine, University of California Los Angeles, USA
    Gastroenterology 131:142-52. 2006
    ..We examined the hyperemic response to elevated luminal PCO(2) in the duodenum of anesthetized rats luminally exposed to high CO(2) saline to help elucidate luminal acid-sensing mechanisms...
  21. ncbi Degradation and effects of the potential mosquito larvicides methazolamide and acetazolamide in sheepshead minnow (Cyprinodon variegatus)
    Maria del Pilar Corena
    The Whitney Laboratory, University of Florida, St Augustine, FL 32080, USA
    Ecotoxicol Environ Saf 64:369-76. 2006
    ..of carbonic anhydrase inhibitors as larvicides, the decomposition and degradation of samples containing methazolamide (MTZ) and acetazolamide (ACZ) in aqueous solution were monitored under different conditions...
  22. ncbi NHE3 inhibition activates duodenal bicarbonate secretion in the rat
    Osamu Furukawa
    Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California 90073, USA
    Am J Physiol Gastrointest Liver Physiol 286:G102-9. 2004
    ..Coperfusion with 0.1 microM indomethacin, 0.5 mM DIDS, or 1 mM methazolamide did not affect S3226-induced DBS. Nevertheless, coperfusion with 0.1 and 0...
  23. ncbi Effects of oral administration of methazolamide on intraocular pressure and aqueous humor flow rate in clinically normal dogs
    Brian J Skorobohach
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN 37996, USA
    Am J Vet Res 64:183-7. 2003
    To determine magnitude and duration of the effect of oral administration of methazolamide at 2 dosages on intraocular pressure (IOP) in dogs in single-dose and multiple-dose trials and to determine aqueous humor flow rate (AHFR) by use ..
  24. ncbi Inhibition of aquaporin-mediated CO2 diffusion and voltage-gated H+ channels by zinc does not alter rabbit lung CO2 and NO excretion
    Erik R Swenson
    Department of Medicine, VA Puget Sound Health Care System, University of Washington, Seattle, WA 98108, USA
    Clin Sci (Lond) 103:567-75. 2002
    ..For comparison, red cell and lung carbonic anhydrases (CAs) were inhibited by 0.1 mM methazolamide. ZnCl(2) had no effect on CO(2) exchange when inspired CO(2) was altered between 2% and 5% in 5-min intervals...
  25. ncbi Carbonic anhydrase in the adult mosquito midgut
    Maria del Pilar Corena
    The Whitney Laboratory, University of Florida, Saint Augustine, FL 32080, USA
    J Exp Biol 208:3263-73. 2005
    ..We also tested the effect of CA inhibitors such as methazolamide and acetazolamide in the alkalization of the midgut in females from these species...
  26. ncbi Carbachol-induced fluid movement through methazolamide-sensitive bicarbonate production in rat parotid intralobular ducts: quantitative analysis of fluorescence images using fluorescent dye sulforhodamine under a confocal laser scanning microscope
    Tetsuji Nakamoto
    Department of Removable Prosthodontics, Hiroshima University Faculty of Dentistry, Japan
    Eur J Cell Biol 81:497-504. 2002
    ..clearance of the fluorescent dye was divided into two phases by the sensitivity to external Ca2+ and methazolamide, an inhibitor for carbonic anhydrase...
  27. pmc Carbonic anhydrase II and alveolar fluid reabsorption during hypercapnia
    Jiwang Chen
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Am J Respir Cell Mol Biol 38:32-7. 2008
    ..Inhibition of CAII by acetazolamide or methazolamide delayed the decrease in the intracellular pH observed during hypercapnia in cultured AECI, AECII, and AECI-..
  28. ncbi Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the perfluorobenzoyl analogue of methazolamide. Implications for the drug design of fluorinated inhibitors
    Francesco Abbate
    Universita degli Studi di Firenze, Polo Scientifico, Dipartimento di Chimica, Laboratorio di Chimica Bioinorganica, Via della Lastruccia, 3, Rm 188, 1 50019 Sesto Fiorentino, Firenze, Italy
    J Enzyme Inhib Med Chem 18:303-8. 2003
    ..5 nM) compared to the lead molecule, methazolamide, a clinically used drug (KI of 14 nM)...
  29. pmc Inhibitors of cytochrome c release with therapeutic potential for Huntington's disease
    Xin Wang
    Neuroapoptosis Laboratory and Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:9473-85. 2008
    ..Given that many of these compounds have been approved by the Food and Drug Administration for clinical usage and cross the blood-brain barrier, these drugs may lead to trials in patients...
  30. ncbi Pharmacological impact on loop gain properties to prevent irregular breathing
    H Kiwull-Schöne
    Department of Physiology, Ruhr University Bochum, Germany
    J Physiol Pharmacol 59:37-45. 2008
    ..Acetazolamide significantly reduced G by 42.0 +/- 9.3% and methazolamide by 35.0 +/- 9.5% (each n = 7, P<0.01). Irrespective of the substance, NHE3 inhibition reduced G by 33...
  31. pmc Gramicidin-perforated patch recording revealed the oscillatory nature of secretory Cl- movements in salivary acinar cells
    Makoto Sugita
    Department of Oral Physiology, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1 2 3, Minami Ku, Hiroshima 734 8553, Japan
    J Gen Physiol 124:59-69. 2004
    ..In contrast, neither methazolamide, a carbonic anhydrase inhibitor, nor elimination of external HCO(3)(-) had significant effects, suggesting ..
  32. ncbi [Diuretic therapy in heart failure]
    G Splendiani
    Dipartimento di Nefrologia e Dialisi, Policlinico Tor Vergata, Rome
    G Ital Nefrol 23:S74-6. 2006
    ..divide the diuretics into six categories: 1) carbonic anhydrase inhibitors: acetazolamide, dichlorphenamide, methazolamide; 2) osmotic diuretics: glycerol, mannitol, urea; 3) loop diuretics: furosemide, bumetanide, ethacrynic acid, ..
  33. ncbi Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides
    Daniela Vullo
    Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino Firenze, Italy
    Bioorg Med Chem Lett 15:971-6. 2005
    ..of aromatic and heterocyclic sulfonamides, including some of the clinically used derivatives (acetazolamide, methazolamide, ethoxzolamide, dichlorophenamide, dorzolamide, brinzolamide and benzolamide), as well as the sulfamate ..
  34. doi Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides
    Anthony Bertucci
    Centre Scientifique de Monaco, Avenue Saint Martin, MC 98000 Principality of Monaco, Monaco
    Bioorg Med Chem 17:5054-8. 2009
    ..been investigated with a series of sulfonamides, including some clinically used derivatives (acetazolamide, methazolamide, ethoxzolamide, dichlorophenamide, dorzolamide, brinzolamide, benzolamide, and sulpiride, or indisulam, a ..
  35. ncbi The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents
    Francesco Mincione
    U O Oculistica Az USL 3, Val di Nievole, Ospedale di Pescia, Pescia, Italy
    Curr Pharm Des 14:649-54. 2008
    ..2.1.1) isoforms present in the eyes (CA I, II, IV and XII), with sulfonamides such as acetazolamide, methazolamide, ethoxzolamide and dichlorophenamide, is still widely used for the systemic treatment of glaucoma...
  36. ncbi Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides
    Daniela Vullo
    Laboratorio di Chimica Bioinorganica, Universita degli Studi di Firenze, Rm 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino Firenze, Italy
    J Med Chem 47:1272-9. 2004
    ..The clinically used inhibitors acetazolamide, methazolamide, ethoxzolamide, dorzolamide, brinzolamide, and topiramate on the other hand were less effective CA V ..
  37. ncbi Theoretical study of gas-phase acidity, pKa, lipophilicity, and solubility of some biologically active sulfonamides
    Milan Remko
    Department of Pharmaceutical Chemistry, Comenius University, Odbojarov 10, SK 832 32 Bratislava, Slovakia
    Bioorg Med Chem 12:5395-403. 2004
    The geometries of 19 biologically active substituted sulfonamides (including clinically useful acetazolamide, methazolamide, ethoxzolamide, dichlorophenamide, dorzolamide, and brinzolamide) in both neutral and deprotonated forms, were ..
  38. ncbi The effects of topical and general anesthesia on ocular drug levels and intraocular pressure lowering activity of topically applied carbonic anhydrase inhibitors
    A Bar-Ilan
    Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville
    J Ocul Pharmacol 4:1-12. 1988
    ..This did not affect the permeability and activity of other, more lipophilic, CAI like methazolamide and ethoxzolamide (E)...
  39. pmc Alkalinization in the isolated and perfused anterior midgut of the larval mosquito, Aedes aegypti
    Horst Onken
    Department of Biological Sciences, Wagner College, Staten Island, NY 10301, USA
    J Insect Sci 8:1-20. 2008
    ..The carbonic anhydrase inhibitor, methazolamide (50 micromol l(-1)), on either the luminal or hemolymph-side, or the inhibitor of anion transport, DIDS (1 ..
  40. ncbi The development of topically acting carbonic anhydrase inhibitors as anti-glaucoma agents
    Francesco Mincione
    U O Oculistica Az USL 3, Val di Nievole, Ospedale di Pescia, Pescia, Italy
    Curr Top Med Chem 7:849-54. 2007
    Carbonic anhydrase inhibitors (CAIs) such as acetazolamide, methazolamide, ethoxzolamide and dichlorophenamide were and still are widely used systemic antiglaucoma drugs...
  41. ncbi Saccharomyces cerevisiae β-carbonic anhydrase: inhibition and activation studies
    Semra Isik
    Science and Art Faculty, Department of Biology, Balikesir University, Balikesir, Turkey
    Curr Pharm Des 16:3327-36. 2010
    ..The clinically used sulfonamides/sulfamate (acetazolamide, ethoxzolamide, methazolamide, dorzolamide, topiramate, celecoxib, etc...
  42. pmc Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
    Caroli Genis
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida 32610, USA
    Biochemistry 48:1322-31. 2009
    ..with five CA sulfonamide-based inhibitors (acetazolamide, benzolamide, chlorzolamide, ethoxzolamide, and methazolamide), and compared to CA II...
  43. pmc Studies on bicarbonate transporters and carbonic anhydrase in porcine nonpigmented ciliary epithelium
    Mohammad Shahidullah
    Department of Physiology, University of Arizona, Tucson, Arizona 85724, USA
    Invest Ophthalmol Vis Sci 50:1791-800. 2009
    ..Bicarbonate transport plays a role in aqueous humor (AH) secretion. The authors examined bicarbonate transport mechanisms and carbonic anhydrase (CA) in porcine nonpigmented ciliary epithelium (NPE)...
  44. ncbi Focal CO2/H+ alters phrenic motor output response to chemical stimulation of cat pre-Botzinger complex in vivo
    Irene C Solomon
    Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York 11794 8661, USA
    J Appl Physiol (1985) 94:2151-7. 2003
    ..Focal tissue acidosis was produced by blockade of carbonic anhydrase with either focal acetazolamide (AZ) or methazolamide (MZ) microinjection...
  45. ncbi PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3- exchanger in the upper villous epithelium of the murine duodenum
    Janet E Simpson
    Department of Biomedical Sciences, University of Missouri, Columbia, MO, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1079-88. 2007
    ..in the PAT-1(-) villous epithelium but increased to WT levels in the absence of CO(2)/HCO(3)(-) or during methazolamide treatment...
  46. doi Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate
    Tomoko Minakuchi
    Department of Gastroenterology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan, and Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Room 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino Firenze, Italy
    J Med Chem 52:2226-32. 2009
    ..values in the range of 1-10 microM, but several derivatives, including sulfanilyl-sulfonamides acetazolamide, methazolamide, dichlorophenamide, dorzolamide, brinzolamide, benzolamide, and the sulfamate topiramate, exhibited ..
  47. doi Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides
    Alessio Innocenti
    Universita degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Sesto Fiorentino, Florence, Italy
    Bioorg Med Chem 17:4503-9. 2009
    ..6 microM. The best Nce103 inhibitors were acetazolamide, methazolamide, bromosulfanilamide, and 4-hydroxymethylbenzenesulfonamide (K(I)s<500 nM)...
  48. ncbi The alpha and beta classes carbonic anhydrases from Helicobacter pylori as novel drug targets
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical Schoo, Nankoku, Kochi 783 8505, Japan
    Curr Pharm Des 14:622-30. 2008
    ..Furthermore, certain CA inhibitors, such as acetazolamide and methazolamide, were shown to inhibit the bacterial growth in vitro...
  49. pmc Muscarinic receptor-induced acidification in sublingual mucous acinar cells: loss of pH recovery in Na+-H+ exchanger-1 deficient mice
    H V Nguyen
    Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Physiol 523:139-46. 2000
    ..niflumate, and was prevented in the absence of HCO3- by treatment with the carbonic anhydrase inhibitor methazolamide. These results indicate that the muscarinic-induced acidification is due to HCO3- loss, probably mediated by ..
  50. doi Cyclodextrin solubilization of carbonic anhydrase inhibitor drugs: formulation of dorzolamide eye drop microparticle suspension
    Phatsawee Jansook
    Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland
    Eur J Pharm Biopharm 76:208-14. 2010
    ..Phase-solubility of each drug tested (i.e. methazolamide, brinzolamide and dorzolamide HCl) was determined in either pure water or an aqueous eye drop medium...
  51. ncbi Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays
    Satinder S Sarang
    Biotechnology Center, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA
    Physiol Genomics 11:45-52. 2002
    ..We identified 26 neuroprotective compounds, of which megestrol, meclizine, verapamil, methazolamide, sulindac, and retinol were examined in greater detail...
  52. doi Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV
    Mika Hilvo
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 6, FI 33520, Tampere, Finland
    J Med Chem 52:646-54. 2009
    ..Best mCA XV inhibitors were celecoxib, sulfanilyl-sulfonamides, methazolamide, ethoxzolamide, dorzolamide, brinzolamide, and sulthiame, with K(I)s in the range of 45-65 nM...
  53. ncbi The extremo-α-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium azorense is highly inhibited by sulfonamides
    Daniela Vullo
    Universita degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Rm 188, Via della Lastruccia 3, 50019 Sesto Fiorentino Florence, Italy
    Bioorg Med Chem 21:4521-5. 2013
    ..Many clinically used sulfonamides, such as acetazolamide, methazolamide, ethoxzolamide, dichlorophenamide, dorzolamide, brinzolamide, topiramate, celecoxib and sulpiride were low ..
  54. ncbi Interactions of human organic anion transporters with diuretics
    Habib Hasannejad
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    J Pharmacol Exp Ther 308:1021-9. 2004
    ..bumetanide, ethacrynic acid, and furosemide; and carbonic anhydrase inhibitors, including acetazolamide and methazolamide. These diuretics inhibited organic anion uptake mediated by hOAT1, hOAT2, hOAT3, and hOAT4 in a competitive ..
  55. pmc A case of paclitaxel-induced maculopathy treated with methazolamide
    Nam Kyun Koo
    Department of Ophthalmology, Dongkang Hospital, Ulsan, Korea
    Korean J Ophthalmol 26:394-7. 2012
    ..is significant, replacing paclitaxel with another agent was not warranted; therefore, maintenance therapy with methazolamide was performed before and after administering the anti-cancer agent...
  56. doi Impact of hemolysis during sample collection: how different is drug concentration in hemolyzed plasma from that of normal plasma?
    Aimin Tan
    PharmaNet Canada Inc, Quebec, Canada
    J Chromatogr B Analyt Technol Biomed Life Sci 901:79-84. 2012
    ..Among the ten different drug compounds tested, only methazolamide, which binds strongly to RBCs, showed significant change in plasma concentration due to hemolysis.
  57. ncbi Inhibition profiling of human carbonic anhydrase II by high-throughput screening of structurally diverse, biologically active compounds
    Rema Iyer
    Department of Biological Sciences, Western Michigan University, Kalamazoo, Michigan 49008 5410, USA
    J Biomol Screen 11:782-91. 2006
    ..Three known sulfonamide CA inhibitors were identified: acetazolamide, methazolamide, and celecoxib...
  58. pmc Acute bilateral angle closure glaucoma induced by methazolamide
    Ahmad A Aref
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL Illinois Eye and Ear Infirmary, University of Illinois at Chicago School of Medicine, Chicago, IL, USA
    Clin Ophthalmol 7:279-82. 2013
    To report a case of bilateral acute myopia and angle closure glaucoma after ingestion of methazolamide.
  59. doi Anticonvulsant/antiepileptic carbonic anhydrase inhibitors: a patent review
    Mayank Aggarwal
    University of Florida, Department of Biochemistry and Molecular Biology, College of Medicine, 1600 SW Archer Rd, PO Box 100245, Gainesville, FL 32610, USA
    Expert Opin Ther Pat 23:717-24. 2013
    ..One indirect pathway for the treatment of epilepsy includes the inhibition of carbonic anhydrase (CA), thereby increasing CO(2) levels in the brain...
  60. doi Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid β and the Asn23 Iowa mutation
    Silvia Fossati
    Department of Pathology, New York University School of Medicine, New York, NY 10016, U S A
    Biochem J 456:347-60. 2013
    ..b>Methazolamide, a cytochrome c release inhibitor, exerted a protective effect in both cell types, suggesting that ..
  61. ncbi Evaluation of the therapeutic potential of carbonic anhydrase inhibitors in two animal models of dystrophin deficient muscular dystrophy
    Jean Giacomotto
    Centre de Genetique Moleculaire et Cellulaire, UMR 5534, Universite Lyon 1, 69622 Villeurbanne Cedex, France
    Hum Mol Genet 18:4089-101. 2009
    ..Two of the most active hits obtained were methazolamide and dichlorphenamide, carbonic anhydrase inhibitors widely used in human therapy. In C...
  62. pmc Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epithelium
    Janet E Simpson
    Dalton Cardiovascular Research Center, Univ of Missouri Columbia, 65211, USA
    Am J Physiol Gastrointest Liver Physiol 298:G683-91. 2010
    ..with carbonic anhydrase II (CAII), and studies using CAII(-) intestine or the pharmacological inhibitor methazolamide on WT intestine resulted in increased epithelial acidification during Gly-Sar exposure...
  63. pmc Duodenal acidity "sensing" but not epithelial HCO3- supply is critically dependent on carbonic anhydrase II expression
    Markus Sjöblom
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover 30625, Germany
    Proc Natl Acad Sci U S A 106:13094-9. 2009
    ..The complete inhibition of tissue CAs by luminal methazolamide and i.v...
  64. ncbi Purification and characterization of carbonic anhydrase from the saliva of the rat
    J B Feldstein
    J Biol Chem 259:5447-53. 1984
    ..L., and Briggle, T.V. (1982) J. Biol. Chem. 257, 12056-12059). These observations suggest to us that salivary carbonic anhydrase is a secretory product...
  65. ncbi A Na(+)-dependent mechanism is involved in mucosal uptake of cinnamic acid across the jejunal brush border in rats
    S Wolffram
    Institute of Veterinary Physiology, University of Zurich, Switzerland
    J Nutr 125:1300-8. 1995
    ..jejunal uptake of cinnamate seems to be influenced by intracellular HCO3- and/or pH, since the addition of methazolamide to a HCO3(-)- and CO2-free incubation medium significantly inhibited mucosal cinnamate uptake, whereas ..
  66. doi Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis
    Isao Nishimori
    Department of Gastroenterology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    J Med Chem 52:3116-20. 2009
    ..Sulfanilyl-sulfonamides, acetazolamide, methazolamide, ethoxzolamide, dichlorophenamide, dorzolamide, brinzolamide, benzolamide, and zonisamide, showed effective, ..
  67. ncbi Metal complexes of the carbonic anhydrase inhibitor methazolamide (Hmacm). Crystal structure of the Zn(macm)2(NH3)2. Anticonvulsant properties of the Cu(macm)2(NH3)3(H2O)
    G Alzuet
    Departamento de Quimica Inorganica, Facultad Farmacia, Universidad de Valencia, Spain
    J Inorg Biochem 57:219-34. 1995
    Complexes of Co(II), Cu(II), and Zn(II) with deprotonated methazolamide and ammonia are synthesized and characterized. The complex Zn(macm)2(NH3)2 crystallizes in the monoclinic C2/c space group with a = 13.468(1), b = 6.759(1), c = 23...
  68. ncbi A physiological measure of carbonic anhydrase in Müller cells
    E A Newman
    Department of Physiology, University of Minnesota, Minneapolis 55455
    Glia 11:291-9. 1994
    ..Cell pH dropped from a steady-state pH of 7.02 in HEPES solution to pH 6.81 in CO2-HCO3-. Methazolamide, a carbonic anhydrase inhibitor, dramatically reduced the initial rate of acidification, demonstrating that ..
  69. ncbi The effect of altitude on tests of reaction time and alertness
    J H Mackintosh
    Birmingham Medical Research Expeditionary Society, Medical School, England
    Aviat Space Environ Med 59:246-8. 1988
    ..The latter explanation is favoured because of reports by other workers of an increase in reaction time with altitude in the absence of AMS...
  70. ncbi Inhibition of mitochondrial carbonic anhydrase and ureagenesis: a discrepancy examined
    S J Dodgson
    Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia 19104 6085
    J Appl Physiol (1985) 63:2134-41. 1987
    ..07 ethoxzolamide, 0.5 methazolamide, 0.7 acetazolamide, and 5.0 p-aminomethylbenzenesulfonamide...
  71. ncbi The hypoxia-induced facilitation of augmented breaths is suppressed by the common effect of carbonic anhydrase inhibition
    Harold J Bell
    Department of Medicine, Penn State University College of Medicine, Milton S Hershey Medical Centre, Hershey, PA, USA
    Respir Physiol Neurobiol 171:201-11. 2010
    ..addressed this question by studying the effects of treatment with an alternative carbonic anhydrase inhibitor, methazolamide, which has been reported to leave carotid body responsiveness to hypoxia intact...
  72. ncbi Effect of chronic carbonic anhydrase inhibitor therapy on bone mineral density in white women
    W M Pierce
    Department of Pharmacology and Toxicology, University of Louisville, KY 40292
    J Bone Miner Res 6:347-54. 1991
    ..glaucoma subjects who were chronic users of the carbonic anhydrase (CA) inhibitors acetazolamide (Az) or methazolamide (Mz)...
  73. ncbi Localization and activity of renal carbonic anhydrase (CA) in CA-II deficient mice
    W F Brechue
    Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville 32610
    Biochim Biophys Acta 1066:201-7. 1991
    ..Urine pH and Cl- excretion were higher and titratable acid output was lower in CAD mice. Inhibition of CA (methazolamide, 25 mg/kg) led in all groups to equivalent increments of urine pH, urine flow, and HCO3-, Na+, and K+ ..
  74. doi Determination of memantine in rat plasma by HPLC-fluorescence method and its application to study of the pharmacokinetic interaction between memantine and methazolamide
    Mohamed G Hassan
    Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al Azhar University, Assiut Branch, Assiut 71524, Egypt
    Biomed Chromatogr 26:214-9. 2012
    ..The fluorescence property and reaction yield of authentic DIB-MT were also examined. The proposed method was successfully applied to study the pharmacokinetic interaction between MT and methazolamide.
  75. ncbi Effect of thiazides on colonic NaCl absorption: role of carbonic anhydrase
    D S Goldfarb
    Nephrology Section, Department of Veteran Affairs Medical Center, New York, New York 10010
    Am J Physiol 261:F452-8. 1991
    ..Prior exposure of the colon to the carbonic anhydrase inhibitor methazolamide (0...
  76. doi Biochemical and molecular characterization of stress-induced β-carbonic anhydrase from a C(4) plant, Pennisetum glaucum
    Tanushri Kaul
    Plant Molecular Biology Group, International Centre for Genetic Engineering and Biotechnology ICGEB, Aruna Asaf Ali Marg, New Delhi 110 067, India
    J Plant Physiol 168:601-10. 2011
    ..Recombinant PgCA esterase activity is inhibited by standard CA inhibitors acetazolamide, methazolamide and azide. Subcellular immunostaining studies revealed a chloroplastic localization of PgCA protein...
  77. ncbi Calcium metabolism in acidotic patients induced by carbonic anhydrase inhibitors: responses to citrate
    E Higashihara
    Department of Urology, Faculty of Medicine, University of Tokyo, Japan
    J Urol 145:942-8. 1991
    ..citrate were examined in 51 patients with glaucoma receiving carbonic anhydrase inhibitors (acetazolamide or methazolamide). Metabolic acidosis, hypocitraturia and increased incidence of nephrolithiasis were induced by both drugs...
  78. ncbi Light-evoked changes in extracellular pH in frog retina
    G A Borgula
    Department of Physiology, University of California, San Francisco 94193
    Vision Res 29:1069-77. 1989
    ..Inhibition of carbonic anhydrase (CA) with acetazolamide or methazolamide increased both the proximal and distal retinal delta pH0, suggesting that CA is involved in buffering retinal ..
  79. ncbi Larvae of the midge Chironomus riparius possess two distinct mechanisms for ionoregulation in response to ion-poor conditions
    Hang Nguyen
    Department of Biology, York University, Toronto, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 299:R762-73. 2010
    ..Inhibitors of the Na(+)/H(+) exchangers (EIPA) and carbonic anhydrase (methazolamide) provide evidence for Na(+)/H(+) and Cl(-)/HCO(3)(-) exchange mechanisms in the anal papillae...
  80. ncbi Methazolamide-associated temporary leukopenia and thrombocytopenia
    A M Cohen
    Department of Medicine B, Sackler Medical School, Tel Aviv University, Israel
    DICP 23:58-9. 1989
    A three-week course of methazolamide therapy for chronic open-angle glaucoma resulted in marked leukopenia and thrombocytopenia...
  81. ncbi Chloride dependent intracellular pH increase induced by bepridil in human red blood cells: a possible involvement in correction of ischemic acidosis
    H Kovacic
    Laboratoire de Biophysique, Faculte de Pharmacie, Marseille, France
    J Pharmacol Exp Ther 267:1509-14. 1993
    ..Moreover, intraerythrocytic pH measurement by 31P nuclear magnetic resonance clearly showed that bepridil permits the cell to recover normal pH faster than control.(ABSTRACT TRUNCATED AT 250 WORDS)..
  82. doi Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates
    Semra Isik
    Balikesir University, Science and Art Faculty, Department of Chemistry, Balikesir, Turkey
    Bioorg Med Chem 17:1158-63. 2009
    ..The clinically used sulfonamides/sulfamate (acetazolamide, ethoxzolamide, methazolamide, dorzolamide, topiramate, celecoxib, etc...
  83. doi Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference
    Claudia Temperini
    Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino Firenze, Italy
    Bioorg Med Chem 17:1214-21. 2009
    ..2.1.1) with a very different profile as compared to classical inhibitors, such as acetazolamide, methazolamide, and ethoxzolamide...
  84. ncbi Simulation of the pharmacokinetic profile of methazolamide in blood: effect of erythrocyte carbonic anhydrase binding on drug disposition
    Malaz A AbuTarif
    Division of Pharmaceutics and Industrial Pharmacy, Long Island University, Brooklyn, New York 11201, USA
    Pharm Res 19:551-5. 2002
  85. pmc The carbonic anhydrase inhibitors methazolamide and acetazolamide have different effects on the hypoxic ventilatory response in the anaesthetized cat
    Luc J Teppema
    Department of Anesthesiolgy, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Physiol 574:565-72. 2006
    We compared the effects of the carbonic anhydrase inhibitors methazolamide and acetazolamide (3 mg kg(-1), i.v.) on the steady-state hypoxic ventilatory response in 10 anaesthetized cats...
  86. ncbi Management of essential tremor
    Theresa A Zesiewicz
    Parkinson s Disease and Movement Disorders Center and Department of Neurology, University of South Florida, Harborside Medical Tower, 4 Columbia Drive, Suite 410, Tampa, FL 33606, USA
    Curr Neurol Neurosci Rep 2:324-30. 2002
    ..In patients with medically refractory tremor, alternative therapies, including surgery or injections of botulinum toxin, may be considered...
  87. pmc Epithelial carbonic anhydrases facilitate PCO2 and pH regulation in rat duodenal mucosa
    Misa Mizumori
    Department of Medicine, School of Medicine, University of California, Los Angeles, USA
    J Physiol 573:827-42. 2006
    ..Rat duodena were perfused with solutions of different pH and PCO2 with or without a cell-permeant CA inhibitor methazolamide (MTZ) or impermeant CA inhibitors...
  88. ncbi Functional interaction of carbonic anhydrase and chloride/bicarbonate exchange in human platelets
    Oscar A Gende
    Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Medicas, Univesidad Nacional de La Plata, 60 y 120, 1900 La Plata, Argentina
    Platelets 16:392-7. 2005
    ..study shows that the efflux of HC was slower when the platelets were previously incubated in 100 microM methazolamide. As a conclusion, the recovery of pHi from alkalosis by Na-independent Cl-/HC exchange is facilitated in ..
  89. ncbi Rat adrenal chromaffin cells are neonatal CO2 sensors
    Ana M Muñoz-Cabello
    Departamento de Fisiologia, Hospital Universitario Virgen del Rocio, Universidad de Sevilla, E 41013 Seville, Spain
    J Neurosci 25:6631-40. 2005
    ..Both the CO2-induced internal pH drop and increase in CAT secretion were markedly diminished by methazolamide (2 microm), a membrane-permeant carbonic anhydrase (CA) inhibitor...
  90. ncbi Low-dose PGE2 mimics the duodenal secretory response to luminal acid in mice
    Masahiko Hirokawa
    Center for Ulcer Research and Education Digestive Diseases Research Center, Los Angeles 90073, USA
    Am J Physiol Gastrointest Liver Physiol 286:G891-8. 2004
    ..DIDS, anion channel inhibitor 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB), carbonic anhydrase inhibitor methazolamide, and nonselective cyclooxygenase inhibitor indomethacin were used to inhibit separate components of HCO(3)(-) ..
  91. ncbi Proton-mediated feedback inhibition of presynaptic calcium channels at the cone photoreceptor synapse
    John P Vessey
    Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
    J Neurosci 25:4108-17. 2005
    ..Voltage clamp of isolated HCs revealed an amiloride-sensitive conductance that could mediate modulation of cleft pH dependent on the membrane potential of these postsynaptic cells...
  92. ncbi Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies
    Giuseppina De Simone
    Dipartimento di Chimica Biologica Sezione Biostrutture and Istituto di Biostrutture e Bioimmagini CNR, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy
    Bioorg Med Chem Lett 15:2315-20. 2005
    ..2 nM, of the same order of magnitude as that of the clinically used sulfonamides/sulfamates acetazolamide, methazolamide, ethoxzolamide and topiramate (K(I)s in the range of 5.4-15.4 nM)...
  93. ncbi Acid-base effects on intestinal Cl- absorption and vesicular trafficking
    Alan N Charney
    Nephrology Section, VA Medical Center, 423 East 23rd St, New York, NY 10010, USA
    Am J Physiol Cell Physiol 286:C1062-70. 2004
    ..internalized when Pco(2) was reduced and exocytosed when Pco(2) was increased, and both mucosal wortmannin and methazolamide inhibited exocytosis...
  94. ncbi HCO3- secretion in the esophageal submucosal glands
    Solange Abdulnour-Nakhoul
    The VA Medical Center, Attn Research, Rm 5F151, 1601 Perdido St, New Orleans, LA 70112 2699, USA
    Am J Physiol Gastrointest Liver Physiol 288:G736-44. 2005
    ..and carbachol-stimulated secretions were also blocked by serosal application of atropine, pirenzipine, DIDS, methazolamide, and ethoxzolamide...
  95. ncbi Benzolamide is not a membrane-impermeant carbonic anhydrase inhibitor
    Claudiu T Supuran
    Universita degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Rm 188, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy
    J Enzyme Inhib Med Chem 19:269-73. 2004
    ..and pharmacological studies, together with the clinically employed classical drugs, acetazolamide, methazolamide, ethoxzolamide or dichlorophenamide, it being frequently stated that benzolamide is a membrane-impermeant ..
  96. ncbi Effects of anion and cation inhibitors and carbonic anhydrase inhibitors upon the activity of the gypsy moth (Lepidoptera: Lymantriidae) nucleo-polyhedrovirus
    Martin Shapiro
    Insect Biocontrol Laboratory, USDA ARS, Henry A Wallace Beltsville Agricultural Research Center, MD 20705, USA
    J Econ Entomol 95:237-42. 2002
    ..Five carbonic anhydrase inhibitors were tested and four (acetazolamide, hydrochlorothiazide, methazolamide, sulfanilamide) enhanced the activity of LdMNPV...
  97. pmc Carbonic anhydrase inhibition prevents and reverts cardiomyocyte hypertrophy
    Bernardo V Alvarez
    Department of Physiology, Membrane Protein Research Group, University of Alberta, Edmonton, Canada T6G2H7
    J Physiol 579:127-45. 2007
    ..ETZ and the related CA inhibitor methazolamide prevented hypertrophy in adult cardiomyocytes...
  98. ncbi Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating 2,4,6-trisubstituted-pyridinium-ethylcarboxamido moieties possessing membrane-impermeability and in vivo selectivity for the membrane-bound (CA IV) versus the cytosolic (CA I and CA II
    C T Supuran
    Laboratorio di Chimica Inorganica e Bioinorganica, Universita degli Studi, Florence, Italy
    J Enzyme Inhib 15:381-401. 2000
    ..new type of inhibitors reported here, unlike the classical, clinically used compounds (such as acetazolamide, methazolamide, ethoxzolamide), are unable to penetrate biological membranes, as shown by ex vivo and in vivo perfusion ..
  99. ncbi Dynamics of carotid body responses in vitro in the presence of CO2-HCO3-: role of carbonic anhydrase
    R Iturriaga
    Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia 19104 6085
    J Appl Physiol (1985) 75:1587-94. 1993
    ..of carotid body (CB) function was tested by studying the effects of the membrane-permeable CNA inhibitor methazolamide on the chemosensory responses of the cat CB, perfused and superfused in vitro with cell-free and modified ..
  100. ncbi QSAR studies for the inhibition of the transmembrane carbonic anhydrase isozyme XIV with sulfonamides using PRECLAV software
    Shalini Singh
    Department of Chemistry, Bareilly College, Bareilly, U P, India
    J Enzyme Inhib Med Chem 24:337-49. 2009
    ..2.1.1) by a series of sulfonamides including clinically used derivatives (acetazolamide, methazolamide, ethoxzolamide, dichlorophenamide, dorzolamide, brinzolamide, benzolamide, and zonisamide) are presented...
  101. ncbi Effect of carbonic anhydrase III inhibition on substrate utilization and fatigue in rat soleus
    C Cote
    Laval University, Hospital Center, Ste Foy, PQ, Canada
    Can J Physiol Pharmacol 71:277-83. 1993
    ..Rat soleus muscles were incubated in vitro in a physiological solution with or without CA inhibitor (methazolamide, 1 mM) and submitted to a fatigue protocol...

Research Grants10

  1. Identification of Novel Drugs against Huntington's Disease and Cerebral Ischemia
    Xin Wang; Fiscal Year: 2010
    ..As presented in the Preliminarily Result section, Dr. Wang has demonstrated that methazolamide and melatonin successfully inhibit cytochrome c release, thereby blocking neuronal cell death...
  2. Identification of Novel Drugs against Huntington's Disease and Cerebral Ischemia
    Xin Wang; Fiscal Year: 2007
    ..As presented in the Preliminarily Result section, Dr. Wang has demonstrated that methazolamide and melatonin successfully inhibit cytochrome c release, thereby blocking neuronal cell death...
  3. Identification of Novel Drugs against Huntington's Disease and Cerebral Ischemia
    Xin Wang; Fiscal Year: 2009
    ..As presented in the Preliminarily Result section, Dr. Wang has demonstrated that methazolamide and melatonin successfully inhibit cytochrome c release, thereby blocking neuronal cell death...
  4. CHEMICAL REGULATION OF VENTILATION
    THOMAS HORNBEIN; Fiscal Year: 1980
    ..b>Methazolamide, a specific carbonic anhydrase inhibitor, will be introduced into the spinal fluid in a mock spinal fluid ..
  5. Intestinal Epithelia Ammonium Transport
    ROGER WORRELL; Fiscal Year: 2009
    ..The long term goal of this project is to provide improved treatment for hyperammonemia. ..
  6. Intestinal Epithelia Ammonium Transport
    ROGER WORRELL; Fiscal Year: 2008
    ..The long term goal of this project is to provide improved treatment for hyperammonemia. ..
  7. Intestinal Epithelia Ammonium Transport
    ROGER WORRELL; Fiscal Year: 2009
    ..The long term goal of this project is to provide improved treatment for hyperammonemia. ..
  8. Intestinal Epithelia Ammonium Transport
    Roger T Worrell; Fiscal Year: 2010
    ..The long term goal of this project is to provide improved treatment for hyperammonemia. ..
  9. Intestinal Epithelia Ammonium Transport
    Roger T Worrell; Fiscal Year: 2010
    ..The long term goal of this project is to provide improved treatment for hyperammonemia. ..
  10. Intestinal Epithelia Ammonium Transport
    Roger T Worrell; Fiscal Year: 2010
    ..The long term goal of this project is to provide improved treatment for hyperammonemia. ..