methazolamide

Summary

Summary: A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.

Top Publications

  1. ncbi Non-catalytic role of carbonic anhydrase in rat intestinal absorption
    Alan N Charney
    Nephrology Section, VA Medical Center, New York University School of Medicine, 423 East 23rd Street, New York, NY 10010, USA
    Biochim Biophys Acta 1573:141-8. 2002
  2. pmc Methazolamide and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury
    Xin Wang
    Department of Neurosurgery, Neuroapoptosis Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Stroke 40:1877-85. 2009
  3. pmc Design of cationic nanostructured heterolipid matrices for ocular delivery of methazolamide
    John Youshia
    Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
    Int J Nanomedicine 7:2483-96. 2012
  4. pmc Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo
    Nicky Konstantopoulos
    Metabolic Research Unit, School of Medicine, Deakin University, Geelong, Victoria, Australia
    Diabetes 61:2146-54. 2012
  5. ncbi Bilateral transient myopia, angle-closure glaucoma, and choroidal detachment induced by methazolamide
    Soon Jae Kwon
    Department of Ophthalmology, School of Medicine, Kyungpook National University, 50 Samduk dong 2 ga, Jung Gu, Daegu 700721, Korea
    Jpn J Ophthalmol 56:515-7. 2012
  6. ncbi Stevens-Johnson syndrome induced by methazolamide treatment
    S Shirato
    Department of Ophthalmology, University of Tokyo School of Medicine, Japan
    Arch Ophthalmol 115:550-3. 1997
  7. ncbi A potential new therapeutic system for glaucoma: solid lipid nanoparticles containing methazolamide
    Rui Li
    School of Pharmacy, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, People s Republic of China
    J Microencapsul 28:134-41. 2011
  8. ncbi Preparation and evaluation of in situ gelling ophthalmic drug delivery system for methazolamide
    Yong Qian
    School of Pharmacy, Nanjing Medical University, Nanjing, PR China
    Drug Dev Ind Pharm 36:1340-7. 2010
  9. ncbi Effects of low-dose methazolamide on the control of breathing in cats
    J H L Bijl
    Department of Anesthesiology Leiden University Medical Center Leiden, The Netherlands
    Adv Exp Med Biol 580:257-62; discussion 351-9. 2006
  10. ncbi Effect of methazolamide on chronic macular edema in patients with retinitis pigmentosa
    G A Fishman
    Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago College of Medicine 60612
    Ophthalmology 101:687-93. 1994

Scientific Experts

Detail Information

Publications139 found, 100 shown here

  1. ncbi Non-catalytic role of carbonic anhydrase in rat intestinal absorption
    Alan N Charney
    Nephrology Section, VA Medical Center, New York University School of Medicine, 423 East 23rd Street, New York, NY 10010, USA
    Biochim Biophys Acta 1573:141-8. 2002
    ..Measurements were made in the presence and absence of 0.1 mM methazolamide, a membrane-permeant CA inhibitor. Ringer pH reduction from 7.6 to 7...
  2. pmc Methazolamide and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury
    Xin Wang
    Department of Neurosurgery, Neuroapoptosis Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Stroke 40:1877-85. 2009
    ..We demonstrate that methazolamide and melatonin are protective in cellular and in vivo models of neuronal hypoxia.
  3. pmc Design of cationic nanostructured heterolipid matrices for ocular delivery of methazolamide
    John Youshia
    Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
    Int J Nanomedicine 7:2483-96. 2012
    ..This study assessed the feasibility of using nanostructured lipid matrices (NLMs) for ocular delivery of methazolamide-(MZA) adopting heterolipids composed of novel mixtures of Compritol (®) and cetostearyl alcohol (CSA), and ..
  4. pmc Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo
    Nicky Konstantopoulos
    Metabolic Research Unit, School of Medicine, Deakin University, Geelong, Victoria, Australia
    Diabetes 61:2146-54. 2012
    We previously used Gene Expression Signature technology to identify methazolamide (MTZ) and related compounds with insulin sensitizing activity in vitro...
  5. ncbi Bilateral transient myopia, angle-closure glaucoma, and choroidal detachment induced by methazolamide
    Soon Jae Kwon
    Department of Ophthalmology, School of Medicine, Kyungpook National University, 50 Samduk dong 2 ga, Jung Gu, Daegu 700721, Korea
    Jpn J Ophthalmol 56:515-7. 2012
    We report the case of a patient with acute bilateral transient myopia, secondary angle-closure glaucoma, and choroidal detachment associated with oral administration of methazolamide.
  6. ncbi Stevens-Johnson syndrome induced by methazolamide treatment
    S Shirato
    Department of Ophthalmology, University of Tokyo School of Medicine, Japan
    Arch Ophthalmol 115:550-3. 1997
    Four cases of Stevens-Johnson syndrome considered to be induced by methazolamide were reported. In all of the cases, the first signs of Stevens-Johnson syndrome (i.e...
  7. ncbi A potential new therapeutic system for glaucoma: solid lipid nanoparticles containing methazolamide
    Rui Li
    School of Pharmacy, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, People s Republic of China
    J Microencapsul 28:134-41. 2011
    b>Methazolamide (MTA) is an antiglaucoma drug; however, there are many side effects of its systemic administration with insufficient ocular therapeutic concentrations...
  8. ncbi Preparation and evaluation of in situ gelling ophthalmic drug delivery system for methazolamide
    Yong Qian
    School of Pharmacy, Nanjing Medical University, Nanjing, PR China
    Drug Dev Ind Pharm 36:1340-7. 2010
    In this study, a thermosensitive in situ gelling vehicle was prepared to increase the precorneal resident time and the bioavailability of methazolamide (MTA).
  9. ncbi Effects of low-dose methazolamide on the control of breathing in cats
    J H L Bijl
    Department of Anesthesiology Leiden University Medical Center Leiden, The Netherlands
    Adv Exp Med Biol 580:257-62; discussion 351-9. 2006
  10. ncbi Effect of methazolamide on chronic macular edema in patients with retinitis pigmentosa
    G A Fishman
    Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago College of Medicine 60612
    Ophthalmology 101:687-93. 1994
    To determine the effectiveness of methazolamide for improving visual acuity and macular edema in patients with retinitis pigmentosa.
  11. ncbi Methazolamide 1% in cyclodextrin solution lowers IOP in human ocular hypertension
    E Gudmundsdottir
    Departments of Ophthalmology and Pharmacy, University of Iceland, Reykjavik
    Invest Ophthalmol Vis Sci 41:3552-4. 2000
    To formulate aqueous eye drops containing methazolamide 1% in cyclodextrin solution and to evaluate their effect on intraocular pressure (IOP) in a double-blind randomized trial in humans...
  12. ncbi Methazolamide calcium phosphate nanoparticles in an ocular delivery system
    Rui Chen
    Department of Pharmaceutics, Nanjing Medical University, China
    Yakugaku Zasshi 130:419-24. 2010
    A new system for the local delivery of methazolamide to the eye has been developed based on calcium phosphate (CaP) nanoparticles...
  13. ncbi HLA-B*5901 is strongly associated with methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis
    Sae Hoon Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Pharmacogenomics 11:879-84. 2010
    The carbonic anhydrase inhibitor methazolamide infrequently causes Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). An association between these diseases and the HLA-B59 serotype has been suggested in case reports...
  14. ncbi Inhibition of hypoxia-induced calcium responses in pulmonary arterial smooth muscle by acetazolamide is independent of carbonic anhydrase inhibition
    Larissa A Shimoda
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1002-12. 2007
    ..These results suggest that AZ attenuates HPV by selectively inhibiting hypoxia-induced Ca2+ responses via a mechanism independent of CA inhibition, changes in pH(i), or membrane potential...
  15. pmc Treat ankylosing spondylitis with methazolamide
    Xiaotian Chang
    National Laboratory for Bio Drugs of Ministry of Health, Provincial Laboratory for Modern Medicine and Technology of Shandong, Research Center for Medicinal Biotechnology of Shandong Academy of Medical Sciences, Jingshi Road 18877, Jinan, Shandong 250062, P R China
    Int J Med Sci 8:413-9. 2011
    ..This study aimed to evaluate the effectiveness and safety of methazolamide, an anti-carbonic anhydrase drug, for treating patients with AS.
  16. ncbi Carbonic anhydrase inhibitors are antiarthritic in the rat
    J C Nolan
    Department of Pharmacology, A H Robins Co, Richmond, VA 23220
    Pharmacol Res 24:377-83. 1991
    ..Acetazolamide, ethoxzolamide, methazolamide, and dichlorphenamide reduced paw oedema and attenuated the deterioration of the joints of rats with adjuvant ..
  17. ncbi Double-blind controlled study of methazolamide in the treatment of essential tremor
    K Busenbark
    Department of Neurology, University of Kansas Medical Center, Kansas City 66160 7314
    Neurology 43:1045-7. 1993
    We studied the effect of the carbonic anhydrase inhibitor methazolamide in 25 patients with essential tremor (ET) in a double-blind, placebo-controlled trial...
  18. ncbi Gramicidin-perforated patch analysis on HCO3- secretion through a forskolin-activated anion channel in rat parotid intralobular duct cells
    C Hirono
    Department of Oral Physiology, Hiroshima University School of Dentistry, Hiroshima 734 8553, Japan
    J Membr Biol 180:11-9. 2001
    ..The anion current was markedly suppressed by addition of 1 mM methazolamide, a carbonic anhydrase inhibitor, and removal of external HCO3-...
  19. ncbi Treatment of essential tremor with methazolamide
    M D Muenter
    Lee Silverman Center for Parkinson s Disease and Movement Disorders, Mayo Clinic Scottsdale, AZ 85259
    Mayo Clin Proc 66:991-7. 1991
    We treated 28 patients (16 women and 12 men) who had essential tremor with methazolamide. Their median age was 69 years (range, 34 to 89 years), and the median duration of tremor was 16 years (range, less than 1 to 69 years)...
  20. ncbi Carbonic anhydrases and mucosal vanilloid receptors help mediate the hyperemic response to luminal CO2 in rat duodenum
    Yasutada Akiba
    Department of Medicine, School of Medicine, University of California Los Angeles, USA
    Gastroenterology 131:142-52. 2006
    ..We examined the hyperemic response to elevated luminal PCO(2) in the duodenum of anesthetized rats luminally exposed to high CO(2) saline to help elucidate luminal acid-sensing mechanisms...
  21. ncbi NHE3 inhibition activates duodenal bicarbonate secretion in the rat
    Osamu Furukawa
    Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California 90073, USA
    Am J Physiol Gastrointest Liver Physiol 286:G102-9. 2004
    ..Coperfusion with 0.1 microM indomethacin, 0.5 mM DIDS, or 1 mM methazolamide did not affect S3226-induced DBS. Nevertheless, coperfusion with 0.1 and 0...
  22. ncbi Effects of oral administration of methazolamide on intraocular pressure and aqueous humor flow rate in clinically normal dogs
    Brian J Skorobohach
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN 37996, USA
    Am J Vet Res 64:183-7. 2003
    To determine magnitude and duration of the effect of oral administration of methazolamide at 2 dosages on intraocular pressure (IOP) in dogs in single-dose and multiple-dose trials and to determine aqueous humor flow rate (AHFR) by use ..
  23. ncbi Degradation and effects of the potential mosquito larvicides methazolamide and acetazolamide in sheepshead minnow (Cyprinodon variegatus)
    Maria del Pilar Corena
    The Whitney Laboratory, University of Florida, St Augustine, FL 32080, USA
    Ecotoxicol Environ Saf 64:369-76. 2006
    ..of carbonic anhydrase inhibitors as larvicides, the decomposition and degradation of samples containing methazolamide (MTZ) and acetazolamide (ACZ) in aqueous solution were monitored under different conditions...
  24. ncbi Pharmacological impact on loop gain properties to prevent irregular breathing
    H Kiwull-Schöne
    Department of Physiology, Ruhr University Bochum, Germany
    J Physiol Pharmacol 59:37-45. 2008
    ..Acetazolamide significantly reduced G by 42.0 +/- 9.3% and methazolamide by 35.0 +/- 9.5% (each n = 7, P<0.01). Irrespective of the substance, NHE3 inhibition reduced G by 33...
  25. ncbi Carbonic anhydrase in the adult mosquito midgut
    Maria del Pilar Corena
    The Whitney Laboratory, University of Florida, Saint Augustine, FL 32080, USA
    J Exp Biol 208:3263-73. 2005
    ..We also tested the effect of CA inhibitors such as methazolamide and acetazolamide in the alkalization of the midgut in females from these species...
  26. ncbi Acid-base effects on electrolyte transport in CA II-deficient mouse colon
    D S Goldfarb
    Nephrology Section, Veterans Affairs Medical Center and New York University School of Medicine, New York, New York 10010, USA
    Am J Physiol Gastrointest Liver Physiol 278:G409-15. 2000
    ..Membrane-permeant methazolamide, but not impermeant benzolamide, at 0.1 mM prevented the effects of pH...
  27. ncbi Inhibition of aquaporin-mediated CO2 diffusion and voltage-gated H+ channels by zinc does not alter rabbit lung CO2 and NO excretion
    Erik R Swenson
    Department of Medicine, VA Puget Sound Health Care System, University of Washington, Seattle, WA 98108, USA
    Clin Sci (Lond) 103:567-75. 2002
    ..For comparison, red cell and lung carbonic anhydrases (CAs) were inhibited by 0.1 mM methazolamide. ZnCl(2) had no effect on CO(2) exchange when inspired CO(2) was altered between 2% and 5% in 5-min intervals...
  28. ncbi Carbachol-induced fluid movement through methazolamide-sensitive bicarbonate production in rat parotid intralobular ducts: quantitative analysis of fluorescence images using fluorescent dye sulforhodamine under a confocal laser scanning microscope
    Tetsuji Nakamoto
    Department of Removable Prosthodontics, Hiroshima University Faculty of Dentistry, Japan
    Eur J Cell Biol 81:497-504. 2002
    ..clearance of the fluorescent dye was divided into two phases by the sensitivity to external Ca2+ and methazolamide, an inhibitor for carbonic anhydrase...
  29. pmc Carbonic anhydrase II and alveolar fluid reabsorption during hypercapnia
    Jiwang Chen
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Am J Respir Cell Mol Biol 38:32-7. 2008
    ..Inhibition of CAII by acetazolamide or methazolamide delayed the decrease in the intracellular pH observed during hypercapnia in cultured AECI, AECII, and AECI-..
  30. ncbi Topical inhibition of nasal carbonic anhydrase affects the CO2 detection threshold in rats
    Katheryn E Ferris
    Neuroscience Program, Allegheny College, Meadville, PA 16335, USA
    Chem Senses 32:263-71. 2007
    ..2) to determine the rats' CO(2) detection thresholds before and after nasal perfusion of mammalian Ringers or methazolamide, a CA inhibitor...
  31. pmc Inhibitors of cytochrome c release with therapeutic potential for Huntington's disease
    Xin Wang
    Neuroapoptosis Laboratory and Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:9473-85. 2008
    ..Given that many of these compounds have been approved by the Food and Drug Administration for clinical usage and cross the blood-brain barrier, these drugs may lead to trials in patients...
  32. ncbi Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the perfluorobenzoyl analogue of methazolamide. Implications for the drug design of fluorinated inhibitors
    Francesco Abbate
    Universita degli Studi di Firenze, Polo Scientifico, Dipartimento di Chimica, Laboratorio di Chimica Bioinorganica, Via della Lastruccia, 3, Rm 188, 1 50019 Sesto Fiorentino, Firenze, Italy
    J Enzyme Inhib Med Chem 18:303-8. 2003
    ..5 nM) compared to the lead molecule, methazolamide, a clinically used drug (KI of 14 nM)...
  33. pmc Gramicidin-perforated patch recording revealed the oscillatory nature of secretory Cl- movements in salivary acinar cells
    Makoto Sugita
    Department of Oral Physiology, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1 2 3, Minami Ku, Hiroshima 734 8553, Japan
    J Gen Physiol 124:59-69. 2004
    ..In contrast, neither methazolamide, a carbonic anhydrase inhibitor, nor elimination of external HCO(3)(-) had significant effects, suggesting ..
  34. ncbi [Diuretic therapy in heart failure]
    G Splendiani
    Dipartimento di Nefrologia e Dialisi, Policlinico Tor Vergata, Rome
    G Ital Nefrol 23:S74-6. 2006
    ..divide the diuretics into six categories: 1) carbonic anhydrase inhibitors: acetazolamide, dichlorphenamide, methazolamide; 2) osmotic diuretics: glycerol, mannitol, urea; 3) loop diuretics: furosemide, bumetanide, ethacrynic acid, ..
  35. ncbi Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides
    Anthony Bertucci
    Centre Scientifique de Monaco, Avenue Saint Martin, MC 98000 Principality of Monaco, Monaco
    Bioorg Med Chem 17:5054-8. 2009
    ..been investigated with a series of sulfonamides, including some clinically used derivatives (acetazolamide, methazolamide, ethoxzolamide, dichlorophenamide, dorzolamide, brinzolamide, benzolamide, and sulpiride, or indisulam, a ..
  36. ncbi The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents
    Francesco Mincione
    U O Oculistica Az USL 3, Val di Nievole, Ospedale di Pescia, Pescia, Italy
    Curr Pharm Des 14:649-54. 2008
    ..2.1.1) isoforms present in the eyes (CA I, II, IV and XII), with sulfonamides such as acetazolamide, methazolamide, ethoxzolamide and dichlorophenamide, is still widely used for the systemic treatment of glaucoma...
  37. ncbi Theoretical study of gas-phase acidity, pKa, lipophilicity, and solubility of some biologically active sulfonamides
    Milan Remko
    Department of Pharmaceutical Chemistry, Comenius University, Odbojarov 10, SK 832 32 Bratislava, Slovakia
    Bioorg Med Chem 12:5395-403. 2004
    The geometries of 19 biologically active substituted sulfonamides (including clinically useful acetazolamide, methazolamide, ethoxzolamide, dichlorophenamide, dorzolamide, and brinzolamide) in both neutral and deprotonated forms, were ..
  38. ncbi The development of topically acting carbonic anhydrase inhibitors as anti-glaucoma agents
    Francesco Mincione
    U O Oculistica Az USL 3, Val di Nievole, Ospedale di Pescia, Pescia, Italy
    Curr Top Med Chem 7:849-54. 2007
    Carbonic anhydrase inhibitors (CAIs) such as acetazolamide, methazolamide, ethoxzolamide and dichlorophenamide were and still are widely used systemic antiglaucoma drugs...
  39. ncbi Saccharomyces cerevisiae β-carbonic anhydrase: inhibition and activation studies
    Semra Isik
    Science and Art Faculty, Department of Biology, Balikesir University, Balikesir, Turkey
    Curr Pharm Des 16:3327-36. 2010
    ..The clinically used sulfonamides/sulfamate (acetazolamide, ethoxzolamide, methazolamide, dorzolamide, topiramate, celecoxib, etc...
  40. pmc Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
    Caroli Genis
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida 32610, USA
    Biochemistry 48:1322-31. 2009
    ..with five CA sulfonamide-based inhibitors (acetazolamide, benzolamide, chlorzolamide, ethoxzolamide, and methazolamide), and compared to CA II...
  41. pmc Studies on bicarbonate transporters and carbonic anhydrase in porcine nonpigmented ciliary epithelium
    Mohammad Shahidullah
    Department of Physiology, University of Arizona, Tucson, Arizona 85724, USA
    Invest Ophthalmol Vis Sci 50:1791-800. 2009
    ..Bicarbonate transport plays a role in aqueous humor (AH) secretion. The authors examined bicarbonate transport mechanisms and carbonic anhydrase (CA) in porcine nonpigmented ciliary epithelium (NPE)...
  42. ncbi PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3- exchanger in the upper villous epithelium of the murine duodenum
    Janet E Simpson
    Department of Biomedical Sciences, University of Missouri, Columbia, MO, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1079-88. 2007
    ..in the PAT-1(-) villous epithelium but increased to WT levels in the absence of CO(2)/HCO(3)(-) or during methazolamide treatment...
  43. ncbi Focal CO2/H+ alters phrenic motor output response to chemical stimulation of cat pre-Botzinger complex in vivo
    Irene C Solomon
    Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York 11794 8661, USA
    J Appl Physiol (1985) 94:2151-7. 2003
    ..Focal tissue acidosis was produced by blockade of carbonic anhydrase with either focal acetazolamide (AZ) or methazolamide (MZ) microinjection...
  44. ncbi Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides
    Alessio Innocenti
    Universita degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Sesto Fiorentino, Florence, Italy
    Bioorg Med Chem 17:4503-9. 2009
    ..6 microM. The best Nce103 inhibitors were acetazolamide, methazolamide, bromosulfanilamide, and 4-hydroxymethylbenzenesulfonamide (K(I)s<500 nM)...
  45. ncbi Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate
    Tomoko Minakuchi
    Department of Gastroenterology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan, and Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Room 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino Firenze, Italy
    J Med Chem 52:2226-32. 2009
    ..values in the range of 1-10 microM, but several derivatives, including sulfanilyl-sulfonamides acetazolamide, methazolamide, dichlorophenamide, dorzolamide, brinzolamide, benzolamide, and the sulfamate topiramate, exhibited ..
  46. ncbi The alpha and beta classes carbonic anhydrases from Helicobacter pylori as novel drug targets
    Isao Nishimori
    Department of Gastroenterology and Hepatology, Kochi Medical Schoo, Nankoku, Kochi 783 8505, Japan
    Curr Pharm Des 14:622-30. 2008
    ..Furthermore, certain CA inhibitors, such as acetazolamide and methazolamide, were shown to inhibit the bacterial growth in vitro...
  47. pmc Muscarinic receptor-induced acidification in sublingual mucous acinar cells: loss of pH recovery in Na+-H+ exchanger-1 deficient mice
    H V Nguyen
    Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Physiol 523:139-46. 2000
    ..niflumate, and was prevented in the absence of HCO3- by treatment with the carbonic anhydrase inhibitor methazolamide. These results indicate that the muscarinic-induced acidification is due to HCO3- loss, probably mediated by ..
  48. ncbi Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays
    Satinder S Sarang
    Biotechnology Center, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA
    Physiol Genomics 11:45-52. 2002
    ..We identified 26 neuroprotective compounds, of which megestrol, meclizine, verapamil, methazolamide, sulindac, and retinol were examined in greater detail...
  49. ncbi Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV
    Mika Hilvo
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 6, FI 33520, Tampere, Finland
    J Med Chem 52:646-54. 2009
    ..Best mCA XV inhibitors were celecoxib, sulfanilyl-sulfonamides, methazolamide, ethoxzolamide, dorzolamide, brinzolamide, and sulthiame, with K(I)s in the range of 45-65 nM...
  50. ncbi Forskolin-induced HCO3- current across apical membrane of the frog corneal epithelium
    O A Candia
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029
    Am J Physiol 259:C215-23. 1990
    ..b>Methazolamide also inhibited Isc...
  51. pmc Bicarbonate transport along the loop of Henle. I. Microperfusion studies of load and inhibitor sensitivity
    G Capasso
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06510 8026
    J Clin Invest 88:430-7. 1991
    ..min-1 was reached. Methazolamide (2 x 10(-4) M) reduced JHCO3 by 70%; the amiloride analogue ethylisopropylamiloride (EIPA) (2 x 10(-4) M) ..
  52. ncbi Biochemical, histological, and inhibitor studies of membrane carbonic anhydrase in frog gastric acid secretion
    E R Swenson
    Department of Medicine, Department of Veterans Affairs Medical Center, University of Washington, Seattle, Washington 98108, USA
    Am J Physiol Gastrointest Liver Physiol 281:G61-8. 2001
    ..isolated mucosa was measured before and after mucosal addition of a permeant CA inhibitor (methazolamide) and before and after mucosal or serosal addition of two impermeant CA inhibitors of differing molecular mass: ..
  53. ncbi Methazolamide does not impair respiratory work performance in anesthetized rabbits
    Heidrun F Kiwull-Schöne
    Dept of Physiology, Faculty of Medicine, Ruhr Univ, 44780 Bochum, Germany
    Am J Physiol Regul Integr Comp Physiol 297:R648-54. 2009
    ..Among others, the highly diffusible CA-inhibitor methazolamide differs from acetazolamide in that it fails to activate Ca(2+)-dependent potassium channels in skeletal ..
  54. ncbi Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides
    Daniela Vullo
    Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino Firenze, Italy
    Bioorg Med Chem Lett 15:971-6. 2005
    ..of aromatic and heterocyclic sulfonamides, including some of the clinically used derivatives (acetazolamide, methazolamide, ethoxzolamide, dichlorophenamide, dorzolamide, brinzolamide and benzolamide), as well as the sulfamate ..
  55. pmc Alkalinization in the isolated and perfused anterior midgut of the larval mosquito, Aedes aegypti
    Horst Onken
    Department of Biological Sciences, Wagner College, Staten Island, NY 10301, USA
    J Insect Sci 8:1-20. 2008
    ..The carbonic anhydrase inhibitor, methazolamide (50 micromol l(-1)), on either the luminal or hemolymph-side, or the inhibitor of anion transport, DIDS (1 ..
  56. ncbi Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties
    Celine Chazalette
    Universite Joseph Fourier de Grenoble, Laboratoire d Etudes Dynamiques et Structurales de la Sélectivité, Bât C Chimie, 301 rue de la Chimie, Domaine Universitaire, 38400 Saint Martin d Hères Grenoble, France
    Bioorg Med Chem Lett 14:5781-6. 2004
    ..of these sulfonamides was rather low as compared to that of other sulfonamide/sulfamate CA inhibitors, such as methazolamide. Furthermore, the 2-amino/acetamido-indane-5-sulfonic acids prepared during this work also showed interesting ..
  57. ncbi Volume-activated taurine efflux from skate erythrocytes: possible band 3 involvement
    L Goldstein
    Section of Physiology, Brown University, Providence, Rhode Island 02912
    Am J Physiol 260:R1014-20. 1991
    ..Thus there is considerable evidence in favor of the involvement of band 3 in VA taurine efflux, but the issue of the sulfate fluxes remains to be resolved...
  58. ncbi Glutathione conjugation of methazolamide and subsequent reactions in the ciliary body in vitro
    K Kishida
    Department of Ophthalmology, Osaka University Medical School, Japan
    J Pharm Sci 79:638-42. 1990
    Conjugation reaction of methazolamide with glutathione and its subsequent reactions were studied in vitro. Glutathione, cysteinylglycine, and cysteine conjugates of methazolamide were chemically synthesized...
  59. ncbi Purification and characterization of human salivary carbonic anhydrase
    H Murakami
    J Biol Chem 262:1382-8. 1987
    ..iodide, sulfanilamide, and bromopyruvic acid, but the salivary enzyme is less sensitive to acetazolamide and methazolamide than CA II...
  60. ncbi Methazolamide for essential voice tremor
    K Busenbark
    Department of Neurology, University of Kansas Medical Center, Kansas City 66160 7314, USA
    Neurology 47:1331-2. 1996
    We studied the safety and efficacy of methazolamide (average dose 168 mg/day) in a placebo-controlled blinded investigation in nine patients with essential voice tremor...
  61. ncbi A comparison between the effect of topical and systemic carbonic anhydrase inhibitors on aqueous humor secretion
    W F Brechue
    University of Florida Health Science Center, College of Medicine, Department of Pharmacology and Therapeutics, Gainesville 32610 0267
    Exp Eye Res 57:67-78. 1993
    ..We studied methazolamide (25 mg kg-1), ethoxzolamide (4 mg kg-1), and MK-927 (2% in 0.5% hydroxyethylcellulose, topical, pH 4.8)...
  62. ncbi Electroretinal changes in the presence of a carbonic anhydrase inhibitor
    G C Broeders
    Department of Ophthalmology, College of Medicine, University of Florida, Gainesville
    Ophthalmologica 196:103-10. 1988
    A specific carbonic anhydrase activity inhibitor (methazolamide) was injected into one vitreous body each of 4 New Zealand White rabbits. Electroretinograms (ERG) were recorded before and several times after the methazolamide injection...
  63. ncbi Carbonic anhydrase inhibitors ameliorate the symptoms of hypokalaemic periodic paralysis in rats by opening the muscular Ca2+-activated-K+ channels
    Domenico Tricarico
    Unit of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, via Orabona no 4, 70126 Bari, Italy
    Neuromuscul Disord 16:39-45. 2006
    ..K+ -deficient rats treated in vivo with dichlorphenamide (DCP), ethoxzolamide (ETX), hydrochlorthiazide (HCT), methazolamide (MTZ), bendroflumethiazide (BFT) and acetazolamide (ACTZ)...
  64. ncbi Topical dorzolamide for the treatment of cystoid macular edema in patients with retinitis pigmentosa
    Sandeep Grover
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 West Taylor Street, Chicago, IL 60612, USA
    Am J Ophthalmol 141:850-8. 2006
    To determine if topical dorzolamide, as observed with the use of systemic acetazolamide and methazolamide, would be effective in treating cystoid macular edema (CME) in patients with retinitis pigmentosa (RP).
  65. ncbi A role for carbonic anhydrase in early eye morphogenesis
    P J Linser
    Whitney Laboratory, St Augustine, FL 32086
    Invest Ophthalmol Vis Sci 30:783-5. 1989
    The carbonic anhydrase inhibitor methazolamide was used to test the hypothesis that carbonic anhydrase activity plays a role in the early morphogenesis of the chick eye...
  66. ncbi Measurement of aqueous humor flow following scleral injection of sulfacetamide as marker: effect of methazolamide, timolol, and pilocarpine
    B P Vogh
    University of Florida College of Medicine, Department of Pharmacology and Therapeutics, Gainesville
    J Ocul Pharmacol 5:293-302. 1989
    ..37 S.E. overall. The data show that inhibition of carbonic anhydrase (CA) in ciliary processes by systemic methazolamide reduces flow 38%. Topical timolol reduces flow 35%...
  67. ncbi The effects of topical and general anesthesia on ocular drug levels and intraocular pressure lowering activity of topically applied carbonic anhydrase inhibitors
    A Bar-Ilan
    Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville
    J Ocul Pharmacol 4:1-12. 1988
    ..This did not affect the permeability and activity of other, more lipophilic, CAI like methazolamide and ethoxzolamide (E)...
  68. ncbi Cyclodextrin solubilization of carbonic anhydrase inhibitor drugs: formulation of dorzolamide eye drop microparticle suspension
    Phatsawee Jansook
    Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland
    Eur J Pharm Biopharm 76:208-14. 2010
    ..Phase-solubility of each drug tested (i.e. methazolamide, brinzolamide and dorzolamide HCl) was determined in either pure water or an aqueous eye drop medium...
  69. ncbi Regulation of anion transport across the uterine epithelium of Gallus domesticus
    K Brockmeier
    Institute for Veterinary Physiology, Justus Liebig Universität Gießen, D 35392 Gießen, Germany
    Poult Sci 90:618-23. 2011
    ..In addition, methazolamide, a blocker of carboanhydrases, significantly reduced baseline I(sc)...
  70. ncbi Changes in intraocular pressure associated with topical dorzolamide and oral methazolamide in glaucomatous dogs
    K N Gelatt
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610 0126, USA
    Vet Ophthalmol 4:61-7. 2001
    To compare the reduction in intraocular pressure (IOP) by topical 2% dorzolamide to oral methazolamide (5 mg/kg) in dogs, and determine if the combination of both drugs would reduce IOP more than either drug administered alone.
  71. ncbi DNA cloning, characterization, and inhibition studies of an α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae
    Sonia Del Prete
    Istituto di Biochimica delle Proteine CNR, Via P Castellino 111, 80131 Napoli, Italy
    J Med Chem 55:10742-8. 2012
    ..and sulfamates led to the detection of a large number of low nanomolar inhibitors, among which are methazolamide, acetazolamide, ethoxzolamide, dorzolamide, brinzolamide, benzolamide, and indisulam (KI values in the range 0...
  72. ncbi Interactions between carbonic anhydrase and its inhibitors revealed by gel electrophoresis and circular dichroism
    E Gianazza
    Istituto di Scienze Farmacologiche, Universita di Milano, Italy
    Electrophoresis 21:1435-45. 2000
    ..of complexes between carbonic anhydrase (CA) and three sulfonamide inhibitors, acetazolamide, dorzolamide and methazolamide, were investigated by spectroscopic and electrophoretic techniques...
  73. ncbi The ocular distribution of methazolamide after corneal and scleral administration: the effect of ionization state
    C W Conroy
    University of Florida College of Medicine, Department of Pharmacology and Therapeutics, Gainesville 32610, USA
    J Ocul Pharmacol Ther 14:565-73. 1998
    The accession of methazolamide in ionized and unionized form to cornea, sclera, aqueous humor and ciliary process was studied 10 minutes following separate application to either sclera or cornea of a 1 mM solution...
  74. ncbi Dual role of CFTR in cAMP-stimulated HCO3- secretion across murine duodenum
    L L Clarke
    Dalton Cardiovascular Research Center, University of Missouri Columbia 65211, USA
    Am J Physiol 274:G718-26. 1998
    ..b>Methazolamide also reduced the Js-->m by 39% but did not affect the delta Isc...
  75. ncbi Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV
    Angela Casini
    Dipartimento di Chimica, Laboratorio di Chimica Bioinorganica, Universita degli Studi di Firenze, Rm 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino, Florence, Italy
    Bioorg Med Chem Lett 13:841-5. 2003
    ..good inhibitory properties against the other two isozymes investigated here, similarly with acetazolamide, methazolamide or dichlorophenamide...
  76. ncbi The effect of transport-blocking drugs on secretion of fluid and electrolytes by the mandibular gland of red kangaroos, Macropus rufus
    A M Beal
    School of Biological Science, University of New South Wales, Sydney, Australia
    Arch Oral Biol 42:705-16. 1997
    ..b>Methazolamide (0...
  77. pmc Barium- or quinine-induced depolarization activates K+, Na+ and cationic conductances in frog proximal tubular cells
    F Discala
    INSERM U 323, Faculte de Medecine Necker Enfants Malades, Paris, France
    J Physiol 448:525-37. 1992
    ..1 mM-methazolamide, to inhibit the rheogenic Na(+)-HCO3-symport, and 1 microM-amiloride, to block Na+ conductance (GNa)...
  78. ncbi Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii
    Alessandra Cincinelli
    Universita degli Studi di Firenze, Dipartimento di Chimica Ugo Schiff, Laboratorio di Chimica Bioinorganica, Rm 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino Firenze, Italy
    Bioorg Med Chem 19:1847-51. 2011
    ..Many clinically used sulfonamides, such as acetazolamide, methazolamide, dorzolamide, brinzolamide and benzolamide were low nanomolar inhibitors, with K(I)s in the range of 5.7-67 nM...
  79. ncbi Carbonic anhydrase inhibitors: aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity
    Marc A Ilies
    University of Agricultural Sciences and Veterinary Medicine, Faculty of Biotechnologies, Department of Chemistry, B dul Marasti nr 59, 71331 Bucharest, Romania
    Bioorg Med Chem 12:2717-26. 2004
    ..processes, CA I, and CA II, of the same order of magnitude as the clinically used drugs acetazolamide and methazolamide. The lipophilicity of the best CA inhibitors was determined and expressed as their experimental log k' IAM and ..
  80. ncbi Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides
    Daniela Vullo
    Laboratorio di Chimica Bioinorganica, Universita degli Studi di Firenze, Rm 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino Firenze, Italy
    J Med Chem 47:1272-9. 2004
    ..The clinically used inhibitors acetazolamide, methazolamide, ethoxzolamide, dorzolamide, brinzolamide, and topiramate on the other hand were less effective CA V ..
  81. pmc A case of paclitaxel-induced maculopathy treated with methazolamide
    Nam Kyun Koo
    Department of Ophthalmology, Dongkang Hospital, Ulsan, Korea
    Korean J Ophthalmol 26:394-7. 2012
    ..is significant, replacing paclitaxel with another agent was not warranted; therefore, maintenance therapy with methazolamide was performed before and after administering the anti-cancer agent...
  82. ncbi Interactions of human organic anion transporters with diuretics
    Habib Hasannejad
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan
    J Pharmacol Exp Ther 308:1021-9. 2004
    ..bumetanide, ethacrynic acid, and furosemide; and carbonic anhydrase inhibitors, including acetazolamide and methazolamide. These diuretics inhibited organic anion uptake mediated by hOAT1, hOAT2, hOAT3, and hOAT4 in a competitive ..
  83. ncbi The extremo-α-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium azorense is highly inhibited by sulfonamides
    Daniela Vullo
    Universita degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Rm 188, Via della Lastruccia 3, 50019 Sesto Fiorentino Florence, Italy
    Bioorg Med Chem 21:4521-5. 2013
    ..Many clinically used sulfonamides, such as acetazolamide, methazolamide, ethoxzolamide, dichlorophenamide, dorzolamide, brinzolamide, topiramate, celecoxib and sulpiride were low ..
  84. ncbi Impact of hemolysis during sample collection: how different is drug concentration in hemolyzed plasma from that of normal plasma?
    Aimin Tan
    PharmaNet Canada Inc, Quebec, Canada
    J Chromatogr B Analyt Technol Biomed Life Sci 901:79-84. 2012
    ..Among the ten different drug compounds tested, only methazolamide, which binds strongly to RBCs, showed significant change in plasma concentration due to hemolysis.
  85. pmc Acute bilateral angle closure glaucoma induced by methazolamide
    Ahmad A Aref
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL Illinois Eye and Ear Infirmary, University of Illinois at Chicago School of Medicine, Chicago, IL, USA
    Clin Ophthalmol 7:279-82. 2013
    To report a case of bilateral acute myopia and angle closure glaucoma after ingestion of methazolamide.
  86. ncbi Anticonvulsant/antiepileptic carbonic anhydrase inhibitors: a patent review
    Mayank Aggarwal
    University of Florida, Department of Biochemistry and Molecular Biology, College of Medicine, 1600 SW Archer Rd, PO Box 100245, Gainesville, FL 32610, USA
    Expert Opin Ther Pat 23:717-24. 2013
    ..One indirect pathway for the treatment of epilepsy includes the inhibition of carbonic anhydrase (CA), thereby increasing CO(2) levels in the brain...
  87. ncbi Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid β and the Asn23 Iowa mutation
    Silvia Fossati
    Department of Pathology, New York University School of Medicine, New York, NY 10016, U S A
    Biochem J 456:347-60. 2013
    ..b>Methazolamide, a cytochrome c release inhibitor, exerted a protective effect in both cell types, suggesting that ..
  88. ncbi Inhibition profiling of human carbonic anhydrase II by high-throughput screening of structurally diverse, biologically active compounds
    Rema Iyer
    Department of Biological Sciences, Western Michigan University, Kalamazoo, Michigan 49008 5410, USA
    J Biomol Screen 11:782-91. 2006
    ..Three known sulfonamide CA inhibitors were identified: acetazolamide, methazolamide, and celecoxib...
  89. ncbi Determination of memantine in rat plasma by HPLC-fluorescence method and its application to study of the pharmacokinetic interaction between memantine and methazolamide
    Mohamed G Hassan
    Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al Azhar University, Assiut Branch, Assiut 71524, Egypt
    Biomed Chromatogr 26:214-9. 2012
    ..The fluorescence property and reaction yield of authentic DIB-MT were also examined. The proposed method was successfully applied to study the pharmacokinetic interaction between MT and methazolamide.
  90. ncbi Effect of thiazides on colonic NaCl absorption: role of carbonic anhydrase
    D S Goldfarb
    Nephrology Section, Department of Veteran Affairs Medical Center, New York, New York 10010
    Am J Physiol 261:F452-8. 1991
    ..Prior exposure of the colon to the carbonic anhydrase inhibitor methazolamide (0...
  91. ncbi Biochemical and molecular characterization of stress-induced β-carbonic anhydrase from a C(4) plant, Pennisetum glaucum
    Tanushri Kaul
    Plant Molecular Biology Group, International Centre for Genetic Engineering and Biotechnology ICGEB, Aruna Asaf Ali Marg, New Delhi 110 067, India
    J Plant Physiol 168:601-10. 2011
    ..Recombinant PgCA esterase activity is inhibited by standard CA inhibitors acetazolamide, methazolamide and azide. Subcellular immunostaining studies revealed a chloroplastic localization of PgCA protein...
  92. ncbi Calcium metabolism in acidotic patients induced by carbonic anhydrase inhibitors: responses to citrate
    E Higashihara
    Department of Urology, Faculty of Medicine, University of Tokyo, Japan
    J Urol 145:942-8. 1991
    ..citrate were examined in 51 patients with glaucoma receiving carbonic anhydrase inhibitors (acetazolamide or methazolamide). Metabolic acidosis, hypocitraturia and increased incidence of nephrolithiasis were induced by both drugs...
  93. ncbi Inhibition of mitochondrial carbonic anhydrase and ureagenesis: a discrepancy examined
    S J Dodgson
    Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia 19104 6085
    J Appl Physiol (1985) 63:2134-41. 1987
    ..07 ethoxzolamide, 0.5 methazolamide, 0.7 acetazolamide, and 5.0 p-aminomethylbenzenesulfonamide...
  94. ncbi Penetration into the anterior chamber via the conjunctival/scleral pathway
    R D Schoenwald
    Division of Pharmaceutics, College of Pharmacy, University of Iowa, Iowa City, USA
    J Ocul Pharmacol Ther 13:41-59. 1997
    ..A constant concentration of methazolamide analogs as well as 6-carboxyfluorescein (6-CB) and rhodamine B (RB) was maintained on either the cornea or the ..
  95. ncbi Larvae of the midge Chironomus riparius possess two distinct mechanisms for ionoregulation in response to ion-poor conditions
    Hang Nguyen
    Department of Biology, York University, Toronto, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 299:R762-73. 2010
    ..Inhibitors of the Na(+)/H(+) exchangers (EIPA) and carbonic anhydrase (methazolamide) provide evidence for Na(+)/H(+) and Cl(-)/HCO(3)(-) exchange mechanisms in the anal papillae...
  96. ncbi A novel system to measure labelled CO2 and HCO3- fluxes across epithelia: corneal epithelium as model tissue
    O A Candia
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Eye Res 63:137-49. 1996
    ..These fluxes were independent of the presence of Cl- in the bathing solutions. The bilateral addition of methazolamide (10(-4) M) reduced both unidirectional fluxes to about 2.0 mu eq h-1 cm-2...
  97. ncbi The hypoxia-induced facilitation of augmented breaths is suppressed by the common effect of carbonic anhydrase inhibition
    Harold J Bell
    Department of Medicine, Penn State University College of Medicine, Milton S Hershey Medical Centre, Hershey, PA, USA
    Respir Physiol Neurobiol 171:201-11. 2010
    ..addressed this question by studying the effects of treatment with an alternative carbonic anhydrase inhibitor, methazolamide, which has been reported to leave carotid body responsiveness to hypoxia intact...
  98. ncbi HCO3- secretion in the esophageal submucosal glands
    Solange Abdulnour-Nakhoul
    The VA Medical Center, Attn Research, Rm 5F151, 1601 Perdido St, New Orleans, LA 70112 2699, USA
    Am J Physiol Gastrointest Liver Physiol 288:G736-44. 2005
    ..and carbachol-stimulated secretions were also blocked by serosal application of atropine, pirenzipine, DIDS, methazolamide, and ethoxzolamide...
  99. ncbi Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies
    Giuseppina De Simone
    Dipartimento di Chimica Biologica Sezione Biostrutture and Istituto di Biostrutture e Bioimmagini CNR, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy
    Bioorg Med Chem Lett 15:2315-20. 2005
    ..2 nM, of the same order of magnitude as that of the clinically used sulfonamides/sulfamates acetazolamide, methazolamide, ethoxzolamide and topiramate (K(I)s in the range of 5.4-15.4 nM)...
  100. ncbi Methazolamide-induced delirium
    M Cyr
    College of Pharmacy, University of Tennessee, Memphis, USA
    Pharmacotherapy 17:387-9. 1997
    A 74-year-old man became delirious 2 days after beginning oral therapy with methazolamide. The delirium was manifested by intermittent psychosis, incontinence of bowel and bladder, lethargy, and disorientation...
  101. ncbi Alkalization of larval mosquito midgut and the role of carbonic anhydrase in different species of mosquitoes
    Maria del Pilar Corena
    The Whitney Laboratory, University of Florida, St Augustine, USA
    Comp Biochem Physiol C Toxicol Pharmacol 137:207-25. 2004
    ..We also tested the effect of CA inhibitors such as methazolamide and acetazolamide in the alkalization of the midgut for these species...