saccharin

Summary

Summary: Flavoring agent and non-nutritive sweetener.

Top Publications

  1. ncbi Nutritional status alters saccharin intake and sweet receptor mRNA expression in rat taste buds
    Ke Chen
    Department of Physiology and Pathophysiology, Xian JiaoTong University School of Medicine, Xian, Shaanxi, PR China
    Brain Res 1325:53-62. 2010
  2. pmc Ontogenetic differences in ethanol's motivational properties during infancy
    Michael E Nizhnikov
    Center for Development and Behavioral Neuroscience, Binghamton University, NY 13902 6000, USA
    Alcohol 46:225-34. 2012
  3. ncbi Mammalian sweet taste receptors
    G Nelson
    Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093, USA
    Cell 106:381-90. 2001
  4. pmc Experience with the high-intensity sweetener saccharin impairs glucose homeostasis and GLP-1 release in rats
    Susan E Swithers
    Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Behav Brain Res 233:1-14. 2012
  5. ncbi Flavor preferences conditioned by intragastric infusion of ethanol in rats
    K Ackroff
    Brooklyn College and the Graduate School, City University of New York, Brooklyn, NY 11210, USA
    Pharmacol Biochem Behav 68:327-38. 2001
  6. pmc Sucrose-predictive cues evoke greater phasic dopamine release than saccharin-predictive cues
    James E McCutcheon
    Department of Psychology, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Synapse 66:346-51. 2012
  7. ncbi Aspartame-fed zebrafish exhibit acute deaths with swimming defects and saccharin-fed zebrafish have elevation of cholesteryl ester transfer protein activity in hypercholesterolemia
    Jae Yong Kim
    School of Biotechnology, Yeungnam University, Gyeongsan 712 749, Republic of Korea
    Food Chem Toxicol 49:2899-905. 2011
  8. pmc Taste uncoupled from nutrition fails to sustain the reinforcing properties of food
    Jeff A Beeler
    Department of Neurobiology, The University of Chicago, Chicago, IL, USA
    Eur J Neurosci 36:2533-46. 2012
  9. ncbi Intake of saccharin, aspartame, acesulfame K and cyclamate in Italian teenagers: present levels and projections
    C Leclercq
    National Institute of Nutrition, Rome, Italy
    Food Addit Contam 16:99-109. 1999
  10. ncbi Transduction for sweet taste of saccharin may involve both inositol 1,4,5-trisphosphate and cAMP pathways in the fungiform taste buds in C57BL mice
    K Nakashima
    Department of Chemistry, Asahi University School of Dentistry, Gifu, Japan
    Cell Physiol Biochem 9:90-8. 1999

Detail Information

Publications226 found, 100 shown here

  1. ncbi Nutritional status alters saccharin intake and sweet receptor mRNA expression in rat taste buds
    Ke Chen
    Department of Physiology and Pathophysiology, Xian JiaoTong University School of Medicine, Xian, Shaanxi, PR China
    Brain Res 1325:53-62. 2010
    ..the preference for palatable solutions and alters sweet taste receptor gene expression in rats, we measured saccharin intake and preference using a two-bottle preference test, and changes in body weight, plasma leptin levels, and ..
  2. pmc Ontogenetic differences in ethanol's motivational properties during infancy
    Michael E Nizhnikov
    Center for Development and Behavioral Neuroscience, Binghamton University, NY 13902 6000, USA
    Alcohol 46:225-34. 2012
    ..Rat pups were intraorally infused with 2.5% of their body weight of saccharin solution (0.1%) and immediately after injected intraperitoneolly (i.p.) with one of six doses of ethanol (0.0-2...
  3. ncbi Mammalian sweet taste receptors
    G Nelson
    Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093, USA
    Cell 106:381-90. 2001
    ..and T1R3 combine to function as a sweet receptor, recognizing sweet-tasting molecules as diverse as sucrose, saccharin, dulcin, and acesulfame-K...
  4. pmc Experience with the high-intensity sweetener saccharin impairs glucose homeostasis and GLP-1 release in rats
    Susan E Swithers
    Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Behav Brain Res 233:1-14. 2012
    ..The present experiments determined whether experience with the high-intensity sweetener saccharin versus the caloric sweetener glucose affected blood glucose homeostasis...
  5. ncbi Flavor preferences conditioned by intragastric infusion of ethanol in rats
    K Ackroff
    Brooklyn College and the Graduate School, City University of New York, Brooklyn, NY 11210, USA
    Pharmacol Biochem Behav 68:327-38. 2001
    ..In Phase 1, chow and water were available ad libitum, and both CS flavors were initially sweetened with saccharin that was then faded out...
  6. pmc Sucrose-predictive cues evoke greater phasic dopamine release than saccharin-predictive cues
    James E McCutcheon
    Department of Psychology, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Synapse 66:346-51. 2012
    ..We were interested in whether cues paired with a non-nutritive sweetener (saccharin) would evoke similar dopamine release as cues paired with a nutritive sweetener (sucrose)...
  7. ncbi Aspartame-fed zebrafish exhibit acute deaths with swimming defects and saccharin-fed zebrafish have elevation of cholesteryl ester transfer protein activity in hypercholesterolemia
    Jae Yong Kim
    School of Biotechnology, Yeungnam University, Gyeongsan 712 749, Republic of Korea
    Food Chem Toxicol 49:2899-905. 2011
    ..To determine the physiologic effect of AS in the presence of hyperlipidemia, zebrafish were fed aspartame or saccharin with a high-cholesterol diet (HCD)...
  8. pmc Taste uncoupled from nutrition fails to sustain the reinforcing properties of food
    Jeff A Beeler
    Department of Neurobiology, The University of Chicago, Chicago, IL, USA
    Eur J Neurosci 36:2533-46. 2012
    ..In agreement with behavioral data, saccharin-evoked (but not sucrose-evoked) dopamine release is greatly attenuated following pre-exposure, suggesting that ..
  9. ncbi Intake of saccharin, aspartame, acesulfame K and cyclamate in Italian teenagers: present levels and projections
    C Leclercq
    National Institute of Nutrition, Rome, Italy
    Food Addit Contam 16:99-109. 1999
    The intake of saccharin, aspartame, acesulfame K and cyclamate was assessed in 212 Italian teenagers aged 13-19 in 1996. Total daily intake of intense sweeteners was assessed on the basis of dietary records (14 consecutive days)...
  10. ncbi Transduction for sweet taste of saccharin may involve both inositol 1,4,5-trisphosphate and cAMP pathways in the fungiform taste buds in C57BL mice
    K Nakashima
    Department of Chemistry, Asahi University School of Dentistry, Gifu, Japan
    Cell Physiol Biochem 9:90-8. 1999
    ..Recordings of taste responses were also made in the chorda tympani nerve. Stimulation of the tongue with saccharin elicited a significant increase in IP3 levels in the fungiform papilla only at 20 mM but in cAMP levels at 3 and ..
  11. ncbi Microstructure of the rat's intake of food, sucrose and saccharin in 24-hour tests
    J C Smith
    Department of Psychology, The Florida State University, Tallahassee 32306 1270, USA
    Neurosci Biobehav Rev 24:199-212. 2000
    ..are presented describing the meal and drinking bout patterns during daylong preference tests between sucrose or saccharin vs. water...
  12. ncbi Saccharin effects on morphine-induced antinociception in the mouse formalin test
    M Abdollahi
    Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14155 6451, Iran
    Pharmacol Res 42:255-9. 2000
    This study was performed to investigate the role of sweetness and taste sensations of the non-caloric sweetener saccharin on pain and morphine antinociception by the formalin test in mice...
  13. ncbi Food dependence in rats selectively bred for low versus high saccharin intake. Implications for "food addiction"
    Veronica Yakovenko
    Occidental College, USA
    Appetite 57:397-400. 2011
    ..The latter was studied in low- (LoS) and high- (HiS) saccharin-consuming rats, who differ in drug self-administration (HiS>LoS) and withdrawal (LoS>HiS)...
  14. ncbi Physicochemical and mechanical properties of carbamazepine cocrystals with saccharin
    Ziyaur Rahman
    Division of Product Quality and Research, Center of Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993 002, USA
    Pharm Dev Technol 17:457-65. 2012
    ..physicochemical, mechanical properties, and stability characteristics of cocrystal of carbamazepine (CBZ) using saccharin (SAC) as a coformer...
  15. ncbi Enduring effects of environmental enrichment on novelty seeking, saccharin and ethanol intake in two rat lines (RHA/Verh and RLA/Verh) differing in incentive-seeking behavior
    A Fernandez-Teruel
    Medical Psychology Unit, Department of Psychiatry and Forensic Medicine, School of Medicine, Autonomous University of Barcelona, Bellaterra 08193, Barcelona, Spain
    Pharmacol Biochem Behav 73:225-31. 2002
    ..behavior in the hole board (including novel objects under the holes), as well as for their preference for saccharin-water and ethanol-water in a two-bottle free-choice paradigm...
  16. ncbi Saccharin and other artificial sweeteners in soils: estimated inputs from agriculture and households, degradation, and leaching to groundwater
    Ignaz J Buerge
    Plant Protection Chemistry, Swiss Federal Research Station Agroscope, Wädenswil, Switzerland
    Environ Sci Technol 45:615-21. 2011
    ..The sweetener saccharin is also registered as additive in piglet feed...
  17. ncbi Bioavailability of indomethacin-saccharin cocrystals
    Min Sook Jung
    College of Pharmacy, Chungnam National University, Daejeon, South Korea Department of Health Sciences, Lulea University of Technology, Lulea, Sweden
    J Pharm Pharmacol 62:1560-8. 2010
    ..The cocrystal of indomethacin (IND), a Biopharmaceutical Classification System class II drug, with saccharin (SAC) has been shown to have higher solubility than IND at all pH...
  18. ncbi Bitter taste receptors for saccharin and acesulfame K
    Christina Kuhn
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Molecular Genetics, 14558 Nuthetal, Germany
    J Neurosci 24:10260-5. 2004
    Weight-conscious subjects and diabetics use the sulfonyl amide sweeteners saccharin and acesulfame K to reduce their calorie and sugar intake...
  19. ncbi Cocaine self-administration punished by i.v. histamine in rat models of high and low drug abuse vulnerability: effects of saccharin preference, impulsivity, and sex
    Nathan A Holtz
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA Electronic address
    Physiol Behav 122:32-8. 2013
    ..animal models of high and low vulnerability to drug abuse: rats selectively bred for high (HiS) and low (LoS) saccharin consumption, rats selected for high (HiI) and low (LoI) impulsivity, and sex differences...
  20. ncbi Lever conditioned stimulus-directed autoshaping induced by saccharin-ethanol unconditioned stimulus solution: effects of ethanol concentration and trial spacing
    Arthur Tomie
    Department of Psychology and Center of Alcohol Studies, Rutgers University, 607 Allison Road, New Brunswick, NJ 08903, USA
    Alcohol 30:35-44. 2003
    Two experiments were designed to evaluate whether brief access to a saccharin-ethanol solution would function as an effective unconditioned stimulus (US) in Pavlovian-autoshaping procedures...
  21. pmc Attenuation of saccharin-seeking in rats by orexin/hypocretin receptor 1 antagonist
    Angie M Cason
    Department of Neurosciences, Medical University of South Carolina, Basic Science Building 406, 173 Ashley Avenue, MSC 510, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 228:499-507. 2013
    ..Because sucrose reinforcement has both a hedonic and caloric component, it remains unknown what aspect of this reward drives its reinforcing value...
  22. ncbi Ingestional responses to metabolic challenges in rats selectively bred for high and low saccharin intake
    Dennis A VanderWeele
    Department of Psychology, Occidental College, 1600 Campus Road, Los Angeles, CA 90041, USA
    Physiol Behav 75:97-104. 2002
    Rats selectively bred on the basis of saccharin intake also differ on some measures of emotional reactivity. The present studies were designed to contribute to our understanding of this association...
  23. ncbi Genotoxicity testing of low-calorie sweeteners: aspartame, acesulfame-K, and saccharin
    Atrayee Bandyopadhyay
    Centre of Advanced Study, Cell and Chromosome Research, Department of Botany, University of Calcutta, Kolkata, India
    Drug Chem Toxicol 31:447-57. 2008
    ..ASP; 7, 14, 28, and 35 mg/kg body weight), acesulfame-K (ASK; 150, 300, and 600 mg/kg body weight), and saccharin (50, 100, and 200 mg/kg body weight) individually...
  24. ncbi Ethanol consumption in rats selectively bred for differential saccharin intake
    N K Dess
    Department of Psychology, Occidental College, Los Angeles, CA 90041, USA
    Alcohol 16:275-8. 1998
    Rat lines selectively bred for high ethanol consumption consume more saccharin solution than do their low-ethanol-consuming counterparts...
  25. ncbi Ethanol, saccharin, and quinine: early ontogeny of taste responsiveness and intake
    Andrey P Kozlov
    Center for Developmental Psychobiology, Department of Psychology, Binghamton University, Binghamton, New York 13902 6000, USA
    Alcohol Clin Exp Res 32:294-305. 2008
    ..Therefore, the present study compared responsiveness to ethanol and solutions with bitter (quinine) and sweet (saccharin) taste in terms of intake and palatability across the first 2 weeks of postnatal life.
  26. ncbi Regulation of intravenous cocaine self-administration in rats selectively bred for high (HiS) and low (LoS) saccharin intake
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN, 55455, USA
    Psychopharmacology (Berl) 190:331-41. 2007
    Rats selectively bred for high saccharin (HiS) intake consume more alcohol and acquire intravenous (i.v.) cocaine self-administration more rapidly than their low saccharin (LoS)-consuming counterparts...
  27. ncbi Responses to basic taste qualities in rats selectively bred for high versus low saccharin intake
    N K Dess
    Occidental College, 1600 Campus Rd, 90041, Los Angeles, CA, USA
    Physiol Behav 69:247-57. 2000
    Rats selectively bred for relatively high (HiS) and relatively low (LoS) saccharin intake were offered sweet (sucrose), bitter (quinine, sucrose octaacetate), salty (sodium chloride), starchy (Polycose((R))), and sour (citric acid) ..
  28. ncbi Consumption of SC45647 and sucralose by rats selectively bred for high and low saccharin intake
    Nancy K Dess
    Department of Psychology, Occidental College, 1600 Campus Road, Los Angeles, CA 90041, USA
    Chem Senses 34:211-20. 2009
    ..The present paper focused on consumption by Occidental High- (HiS) and Low-Saccharin (LoS)-consuming rats in 23-h 2-bottle tests of 2 sweeteners for which few data from rats are available: SC45647 ..
  29. ncbi Self-administration of ethanol and saccharin in newborn rats: effects on suckling plasticity
    E S Petrov
    Center for Developmental Psychobiology, Department of Psychology, State University of New York at Binghamton, 13902 6000, USA
    Behav Neurosci 115:1318-31. 2001
    Responsiveness to a surrogate nipple providing water, saccharin, 5% ethanol, or 10% ethanol was tested in newborn rats naive to suckling (3-5 hr old) on Postnatal Day (P) 0 and in older neonates with regular suckling experience on P1 or ..
  30. pmc Environmental enrichment protects against the acquisition of cocaine self-administration in adult male rats, but does not eliminate avoidance of a drug-associated saccharin cue
    Matthew D Puhl
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Behav Pharmacol 23:43-53. 2012
    ..rats from acquiring cocaine self-administration and from the resultant drug-induced devaluation of a natural saccharin reward cue. Adult male Sprague-Dawley rats were implanted with intravenous jugular catheters...
  31. pmc Differential orexin/hypocretin expression in addiction-prone and -resistant rats selectively bred for high (HiS) and low (LoS) saccharin intake
    Nathan A Holtz
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
    Neurosci Lett 522:12-5. 2012
    Rats that have been selectively bred for high (HiS) saccharin intake demonstrate elevated drug-seeking behavior in several phases of addiction compared to those bred for low (LoS) saccharin intake...
  32. ncbi Bitter taste of saccharin and acesulfame-K
    John Horne
    Department of Food Science, Cornell University, Ithaca, NY 14853, USA
    Chem Senses 27:31-8. 2002
    The relationships among suprathreshold taste responses to acesulfame-K, Na-saccharin and 6-n-propylthiouracil (PROP) were examined in two studies...
  33. pmc Multiple sweet receptors and transduction pathways revealed in knockout mice by temperature dependence and gurmarin sensitivity
    Tadahiro Ohkuri
    Graduate School of Dental Science, Kyushu University, Fukuoka, 812 8582, Japan
    Am J Physiol Regul Integr Comp Physiol 296:R960-71. 2009
    ..All three KO mice exhibited no detectable responses to SC45647, and their responses to saccharin displayed neither GS nor a TDI...
  34. ncbi Measurement of the relative sweetness of stevia extract, aspartame and cyclamate/saccharin blend as compared to sucrose at different concentrations
    H M Cardello
    Department of Food and Nutrition, FCF UNESP, Araraquara, SP, Brazil
    Plant Foods Hum Nutr 54:119-30. 1999
    ..Bertoni] leaf extract (SrB) and the mixture cyclamate/saccharin--two parts of cyclamate and one part of saccharin--(C/S) with the increase in their concentrations, and in ..
  35. pmc Polymorphisms in the taste receptor gene (Tas1r3) region are associated with saccharin preference in 30 mouse strains
    D R Reed
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 24:938-46. 2004
    The results of recent studies suggest that the mouse Sac (saccharin preference) locus is identical to the Tas1r3 (taste receptor) gene...
  36. ncbi Peripheral ghrelin enhances sweet taste food consumption and preference, regardless of its caloric content
    Emmanuel Disse
    Laboratory of Metabolism, Division of Endocrinology, Diabetology and Nutrition, Department of Internal Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Physiol Behav 101:277-81. 2010
    ..We therefore attempted to delineate the involvement of ghrelin in the modulation of non-caloric but highly rewarding consumption...
  37. ncbi A TAS1R receptor-based explanation of sweet 'water-taste'
    Veronica Galindo-Cuspinera
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    Nature 441:354-7. 2006
    ..This 'rebound' activity occurs when equilibrium forces on the two-state allosteric sweet receptors result in their coordinated shift to the activated state upon being released from inhibition by rinsing...
  38. ncbi Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin
    Alexey N Pronin
    Senomyx, 4767 Nexus Centre Drive, San Diego, California 92121, USA
    Curr Biol 17:1403-8. 2007
    ..The same hT2R43 gene allele makes people more sensitive to the bitterness of an artificial sweetener, saccharin. In addition, a closely related gene's (hT2R44's) allele also makes people more sensitive to the bitterness of ..
  39. ncbi Saccharin as a sugar surrogate revisited
    James C Smith
    Department of Psychology, The Florida State University, Tallahassee, FL 32306 1270, USA
    Appetite 38:155-60. 2002
    ..The second paper by Collier and Novell (1967) reported that saccharin was similar to sucrose in that intake increased and then decreased as concentration increased, although in ..
  40. ncbi Failure to change exploration or saccharin preference in rats exposed to chronic mild stress
    R B Harris
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Physiol Behav 63:91-100. 1997
    Chronic mild stress (CMS) exposes animals to unpredictable stressors. Reduced consumption of sucrose or saccharin solutions by CMS rats has been used as a putative measure of anhedonia, typical of depression...
  41. ncbi Effects of chronic mild stress on sexual behavior, locomotor activity and consumption of sucrose and saccharine solutions
    Janne Grønli
    Department of Biomedicine, Section of Physiology, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
    Physiol Behav 84:571-7. 2005
    ..It is concluded that CMS induces comparable alterations to some depression-like symptoms in humans. Saccharine consumption is not a reliable indicator of the hedonic responsiveness to CMS...
  42. pmc Delay discounting of saccharin in rhesus monkeys
    Kevin B Freeman
    Division of Neurobiology and Behavior Research, Department of Psychiatry and Human Behavior, The University of Mississippi Medical Center, Jackson, MS 39216, United States
    Behav Processes 82:214-8. 2009
    ..In the present study, rhesus monkeys were allowed to choose in discrete trials between 0.05% saccharin delivered in different amounts and with different delays...
  43. ncbi Effects of bremazocine on self-administration of smoked cocaine base and orally delivered ethanol, phencyclidine, saccharin, and food in rhesus monkeys: a behavioral economic analysis
    Kelly P Cosgrove
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
    J Pharmacol Exp Ther 301:993-1002. 2002
    ..of bremazocine, the effects of bremazocine pretreatment on the oral self-administration of phencyclidine (PCP), saccharin, and food were also examined...
  44. ncbi The male rat carcinogens limonene and sodium saccharin are not mutagenic to male Big Blue rats
    S D Turner
    Molecular Immunology Programme, The Babraham Institute, Babraham Hall, Babraham, Cambridgeshire CB24AT, UK
    Mutagenesis 16:329-32. 2001
    Limonene and sodium saccharin are male rat specific carcinogens giving rise to renal and bladder tumours, respectively...
  45. ncbi GABAergic transmission in the rat ventral pallidum mediates a saccharin palatability shift in conditioned taste aversion
    Tadashi Inui
    Division of Behavioral Physiology, Department of Behavioral Sciences, Graduate School of Human Sciences, Osaka University, 1 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Eur J Neurosci 30:110-5. 2009
    ..Initially, rats received a paired presentation of 5 mm saccharin or 0.3 mm quinine solution with an intraperitoneal injection of 0...
  46. ncbi Intravenous cocaine and heroin self-administration in rats selectively bred for differential saccharin intake: phenotype and sex differences
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, Medical School, Box 392 Mayo, Minneapolis 55455, USA
    Psychopharmacology (Berl) 161:304-13. 2002
    Rats selectively bred for high intake of a sweet saccharin solution (HiS) consume more ethanol than their low-saccharin intake (LoS) counterparts...
  47. ncbi Alteration of voluntary ethanol and saccharin consumption by the neurosteroid allopregnanolone in mice
    Rachna S Sinnott
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University and Department of Veterans Affairs Medical Center, Portland, OR 97201, USA
    Psychopharmacology (Berl) 162:438-47. 2002
    ..Recent findings indicate that ethanol (EtOH) and ALLOP share common mechanisms of action and that ALLOP may modulate some of EtOH's abuse-related effects...
  48. ncbi Disruption of operant oral self-administration of ethanol, sucrose, and saccharin by the AMPA/kainate antagonist, NBQX, but not the AMPA antagonist, GYKI 52466
    D N Stephens
    Laboratory of Experimental Psychology, University of Sussex, Falmer, Brighton, United Kingdom
    Alcohol Clin Exp Res 23:1914-20. 1999
    ..We therefore examined the role of non-NMDA glutamate-receptors in mediating the reinforcing properties of ethanol in an oral self-administration paradigm...
  49. ncbi Uroplakins and cytokeratins in the regenerating rat urothelium after sodium saccharin treatment
    R Romih
    Institute of Cell Biology, Medical Faculty, Ljubljana, Slovenia
    Histochem Cell Biol 109:263-9. 1998
    A sodium saccharin (NaSac) diet was used to induce cell damage and regeneration in the urothelium of the male rat urinary bladder...
  50. ncbi Quantitative trait loci associated with short-term intake of sucrose, saccharin and quinine solutions in laboratory mice
    D A Blizard
    Center for Developmental and Health Genetics and Intercollege Graduate Program in Genetics, The Pennsylvania State University, University Park 16802, USA
    Chem Senses 24:373-85. 1999
    ..study was simultaneously to map two genetic loci which, collectively, have a large effect on intake of sucrose, saccharin and quinine solutions in mice...
  51. ncbi Cocaine-induced suppression of saccharin intake: a model of drug-induced devaluation of natural rewards
    Patricia Sue Grigson
    Department of Behavioral Science, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Behav Neurosci 116:321-33. 2002
    In Experiment 1, water-deprived Sprague-Dawley rats were given 5 min access to saccharin. This tube retracted, an empty tube advanced, and the rats were given 1 hr to lick the empty tube on a fixed-ratio 10 lick contingency to self-..
  52. pmc Positional cloning of the mouse saccharin preference (Sac) locus
    A A Bachmanov
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Chem Senses 26:925-33. 2001
    Differences in sweetener intake among inbred strains of mice are partially determined by allelic variation of the saccharin preference (Sac) locus...
  53. ncbi Facilitation of aggressive and sexual behaviors by saccharin deprivation in rats
    Irina V Belozertseva
    Laboratory of Behavioral Pharmacology, Institute of Pharmacology, Pavlov Medical University, 6 8 Lev Tolstoy Street, St Petersburg 197089, Russia
    Physiol Behav 80:531-9. 2004
    ..DE) phenomenon is expressed as an increase in the level of free choice consumption of drugs, alcohol, or saccharin following a period of forced abstinence in humans and in several species of laboratory animals...
  54. pmc Sweetener preference of C57BL/6ByJ and 129P3/J mice
    A A Bachmanov
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Chem Senses 26:905-13. 2001
    ..Three main patterns of strain differences were evident. First, sucrose, maltose, saccharin, acesulfame-K, sucralose and SC-45647 were preferred by both strains, but the B6 mice had lower preference ..
  55. pmc Intense sweetness surpasses cocaine reward
    Magalie Lenoir
    University Bordeaux 2, Universite Bordeaux 1, CNRS, UMR 5227, Bordeaux, France
    PLoS ONE 2:e698. 2007
    ..Though there are many biological commonalities between sweetened diets and drugs of abuse, the addictive potential of the former relative to the latter is currently unknown...
  56. ncbi Stress-induced attenuation of acoustic startle in low-saccharin-consuming rats
    Mitzi Gonzales
    Department of Psychology, Occidental College, Los Angeles, CA 90041, USA
    Biol Psychol 79:193-9. 2008
    ..The Occidental low (LoS) and high (HiS) saccharin-consuming rats, which differ in emotional reactivity, are useful in this effort...
  57. ncbi Impulsivity on a Go/No-go task for intravenous cocaine or food in male and female rats selectively bred for high and low saccharin intake
    Justin J Anker
    Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Behav Pharmacol 19:615-29. 2008
    ..inhibition) using cocaine or food reward in addiction-prone and addiction-resistant rats that were bred for high saccharin (HiS) or low saccharin (LoS) intake, respectively...
  58. ncbi Reduction in preference for saccharin by repeated unpredictable stress in mice and its prevention by imipramine
    Andrew Harkin
    Department of Pharmacology, National University of Ireland, Galway
    J Psychopharmacol 16:115-23. 2002
    ..Intermittently, CMS was discontinued and the mice were presented with both water and a palatable saccharin solution (0.1% w/v) in a two-bottle choice test overnight (15 h)...
  59. ncbi Intake of saccharin, salt, and ethanol solutions is increased by infusion of a mu opioid agonist into the nucleus accumbens
    Min Zhang
    Department of Psychiatry, University of Wisconsin Madison, 53719, USA
    Psychopharmacology (Berl) 159:415-23. 2002
    ..Our previous studies have shown that mu opioid stimulation of the nucleus accumbens preferentially augments intake of palatable food containing sucrose and fat...
  60. pmc Cocaine-induced c-Fos expression in rats selectively bred for high or low saccharin intake and in rats selected for high or low impulsivity
    Paul S Regier
    Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    Behav Brain Res 233:271-9. 2012
    ..In this study we used rats that had been selectively bred for high vs. low saccharin intake and rats selected for high vs. low impulsivity for food...
  61. ncbi Lateral parabrachial lesions impair lithium chloride-induced aversive responses but not saccharin-induced flavor preference
    Montserrat Navarro
    Departamento de Neurociencia y Ciencias de la Salud, Universidad de Almeria, 04120 Almeria, Spain
    Brain Res 990:195-202. 2003
    ..Finally, all the animals were tested in a free discriminative flavor-preference task induced by saccharin, a non-caloric reinforcer, which precludes visceral feedback as essential in acquiring the learned response...
  62. pmc Operant responding for sucrose by rats bred for high or low saccharin consumption
    Blake A Gosnell
    Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Ave, St Paul, MN 55108, USA
    Physiol Behav 99:529-33. 2010
    ..For example, rats selectively bred to consume high (HiS) or low (LoS) amounts of a 0.1% saccharin solution (when compared to water consumption), show corresponding differences across several measures of cocaine ..
  63. ncbi Indomethacin-saccharin cocrystal: design, synthesis and preliminary pharmaceutical characterization
    Srinivas Basavoju
    Department of Health Science, Lulea University of Technology, Lulea, S 971 87, Sweden
    Pharm Res 25:530-41. 2008
    ..To design and prepare cocrystals of indomethacin using crystal engineering approaches, with the ultimate objective of improving the physical properties of indomethacin, especially solubility and dissolution rate...
  64. ncbi Selective breeding for differential saccharin intake as an animal model of drug abuse
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
    Behav Pharmacol 19:435-60. 2008
    A positive relationship between the consumption of sweetened dietary substances (e.g. saccharin and sucrose) and drug abuse has been reported in both the human and other animal literature...
  65. ncbi Usage of saccharin in food products and its intake by the population of Lucknow, India
    Meenakshi Tripathi
    Food Toxicology Laboratory, Industrial Toxicology Research Centre, Mahatma Gandhi Marg, P O Box 80, Lucknow 226001, India
    Food Addit Contam 23:1265-75. 2006
    A survey of the usage patterns of the artificial sweetener, saccharin, in edible products and a study of its intake pattern in different population groups has been carried out...
  66. ncbi The NMDA receptor channel blocker memantine and opioid receptor antagonist naltrexone inhibit the saccharin deprivation effect in rats
    E Zakharova
    Institute of Pharmacology, I P Pavlov Medical University, St Petersburg 197089, Russia
    Behav Pharmacol 15:273-8. 2004
    ..The present study aimed to evaluate the effects of these drugs on the development and expression of the saccharin deprivation effect in adult male Wistar rats...
  67. ncbi Effects of topiramate on ethanol and saccharin consumption and preferences in C57BL/6J mice
    Kara I Gabriel
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Alcohol Clin Exp Res 29:75-80. 2005
    ..The current experiment examined the effects of topiramate on ethanol drinking in mice using a continuous access, two-bottle choice procedure...
  68. ncbi Estimated intake of the artificial sweeteners acesulfame-K, aspartame, cyclamate and saccharin in a group of Swedish diabetics
    N G Ilbäck
    Toxicology Division, National Food Administration, Uppsala, Sweden
    Food Addit Contam 20:99-114. 2003
    ..a Swedish study on the estimated intake of the artificial sweeteners acesulfame-K, aspartame, cyclamate and saccharin by children (0-15 years) and adult male and female diabetics (types I and II) of various ages (16-90 years)...
  69. ncbi Single-locus control of saccharin intake in BXD/Ty recombinant inbred (RI) mice: some methodological implications for RI strain analysis
    J K Belknap
    Research Service 151W, VA Medical Center, Portland Oregon
    Behav Genet 22:81-100. 1992
    The sac locus, with a major effect on saccharin preference, was discovered by Fuller (1974) in C57BL/6J (B6), DBA/2J (D2), and derived crosses, and is now supported in the BXD/Ty recombinant inbred (RI) series by a marked bimodal ..
  70. pmc No relationship between sequence variation in protein coding regions of the Tas1r3 gene and saccharin preference in rats
    Ke Lu
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Chem Senses 30:231-40. 2005
    ..whether mice and rats share the same Tas1r3 alleles, and whether this gene might explain the large difference in saccharin preference among rats. We conducted three experiments to test this...
  71. pmc High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4
    X Li
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    Mamm Genome 12:13-6. 2001
    The Sac (saccharin preference) locus affecting mouse behavioral and neural responsiveness to sweeteners has been mapped to distal Chr 4...
  72. ncbi Single-locus control of saccharin preference in mice
    J L Fuller
    J Hered 65:33-6. 1974
  73. ncbi Mapping of QTL influencing saccharin consumption in the selectively bred alcohol-preferring and -nonpreferring rat lines
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    Behav Genet 32:57-67. 2002
    ..b>Saccharin consumption (ml/48 h) and saccharin intake (ml/kg/day) were also measured in the F2 sample and were ..
  74. ncbi Genetic correlational analyses of ethanol reward and aversion phenotypes in short-term selected mouse lines bred for ethanol drinking or ethanol-induced conditioned taste aversion
    Tamara J Phillips
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Neurosci 119:892-910. 2005
    ..Compared with STDRLO, STDRHI mice consumed more saccharin and less quinine, exhibited greater ethanol-induced conditioned place preference (CPP), and showed reduced ..
  75. ncbi Metabotropic glutamate receptor antagonists but not NMDA antagonists affect conditioned taste aversion acquisition in the parabrachial nucleus of rats
    Karel Vales
    Institute of Physiology, Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic
    Exp Brain Res 169:50-7. 2006
    ..neurotransmission in the PBN during CTA demonstrated that the extracellular level of glutamate rises during saccharin drinking (Bielavska et al. in Brain Res 887:413-417, 2000)...
  76. ncbi Cocaine-induced conditioned taste avoidance over extended conditioned stimulus-unconditioned stimulus intervals
    K B Freeman
    Psychopharmacology Laboratory, Department of Psychology, American University, Washington, DC 20016, USA
    Behav Pharmacol 16:591-5. 2005
    ..Using saccharin as the conditioned stimulus, two taste-drug pairings were followed by six extinction trials during which ..
  77. ncbi Single experience learning of host fruit selection by lepidopteran larvae
    Maciej A Pszczolkowski
    Department of Entomology, Washington State University, Pullman, 99163, USA
    Physiol Behav 86:168-75. 2005
    ..We speculate that conjunction of preference induction with short retention time and averse conditioning with long retention time provide an optimal adaptive strategy of host fruit selection for codling moth neonates...
  78. ncbi The taste of sickness: lipopolysaccharide-induced finickiness in rats
    Arnaud Aubert
    EA 3248, Psychobiologie des Emotions, Faculte des Sciences, DESCO, Parc de Grandmont, F 37200 Tours, France
    Physiol Behav 84:437-44. 2005
    ..In a first experiment, the effects of lipopolysaccharide-induced sickness were assessed on preference for saccharin and aversion for quinine in rats using the two-bottle test paradigm...
  79. ncbi Requirement of NMDA receptor reactivation for consolidation and storage of nondeclarative taste memory revealed by inducible NR1 knockout
    Zhenzhong Cui
    Center for Systems Neurobiology, Department of Pharmacology, Boston University, Boston, MA 02118, USA
    Eur J Neurosci 22:755-63. 2005
    ....
  80. ncbi An assessment of sex differences in nicotine-induced conditioned taste aversions
    Jennifer A Rinker
    Psychopharmacology Laboratory, Department of Psychology, American University, Washington, DC 20016, USA
    Pharmacol Biochem Behav 88:427-31. 2008
    ..To address this issue, in the present experiment male and female rats were given limited access to saccharin followed by an intraperitoneal (i.p.) injection of either vehicle or nicotine (0.4, 0.8 or 1.2 mg/kg)...
  81. ncbi Calcium deprivation increases the palatability of calcium solutions in rats
    Stuart A McCaughey
    Monell Chemical Senses Center, 3500 Market St, Philadelphia, PA 19104 3308, USA
    Physiol Behav 84:335-42. 2005
    ..HCl, 2.5 mM sodium saccharin, and deionized water...
  82. ncbi Further evidence for conditioned taste aversion induced by forced swimming
    Takahisa Masaki
    Psychology Section, Department of Integrated Psychological Science, Kwansei Gakuin University, Nishinomiya, 662 8501, Japan
    Physiol Behav 84:9-15. 2005
    ..These results, taken together, suggest that energy expenditure caused by physical exercise might be involved in the development of taste aversion...
  83. ncbi Odor of taste stimuli in conditioned "taste" aversion learning
    Elizabeth D Capaldi
    Department of Psychology, University at Buffalo, Buffalo, NY 14260, USA
    Behav Neurosci 118:1400-8. 2004
    ..In Experiment 1, saccharin or salt were either mixed in distilled water, so the rats could taste and smell them, or presented on disks ..
  84. ncbi 5,7-dihydroxytryptamine lesions of the dorsal and median raphe nuclei interfere with lithium-induced conditioned gaping, but not conditioned taste avoidance, in rats
    Cheryl L Limebeer
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada
    Behav Neurosci 118:1391-9. 2004
    ..implanted with intraoral cannulas for fluid delivery and received a single conditioning trial in which 2-min saccharin infusion was followed by either lithium or saline administration...
  85. pmc Higher locomotor response to cocaine in female (vs. male) rats selectively bred for high (HiS) and low (LoS) saccharin intake
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, United States
    Pharmacol Biochem Behav 88:94-104. 2007
    Rats selectively bred for high saccharin consumption (HiS) self-administer more oral ethanol and i.v. cocaine than those selectively bred for low saccharin consumption (LoS)...
  86. ncbi Neurons in dopamine-rich areas of the rat medial midbrain predominantly encode the outcome-related rather than behavioural switching properties of conditioned stimuli
    David I G Wilson
    School of Psychology, University of St Andrews, St Mary s, Quadrangle, South Street, St Andrews, Fife, Scotland KY16 9JP, UK
    Eur J Neurosci 23:205-18. 2006
    ..to conditioned stimuli in the task, which varied according to the outcome with which they were associated (saccharin or quinine solution) and according to whether they triggered a switch in the ongoing sequence of the animal's ..
  87. pmc Facilitation of taste memory acquisition by experiencing previous novel taste is protein-synthesis dependent
    Maayan Merhav
    Department of Neurobiology and Ethology, Faculty for Science, Haifa University, Haifa 30905, Israel
    Learn Mem 15:501-7. 2008
    ..Moreover, the results imply that learning is enhanced on the level of acquisition but not of molecular consolidation...
  88. pmc Glucocorticoids enhance taste aversion memory via actions in the insular cortex and basolateral amygdala
    Maria Isabel Miranda
    Departamento de Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Queretaro, 76230, Mexico
    Learn Mem 15:468-76. 2008
    ..0 or 3.0 mg/kg) administered subcutaneously to male Sprague-Dawley rats immediately after the pairing of saccharin consumption with the visceral malaise-inducing agent lithium chloride (LiCl) dose-dependently increased aversion ..
  89. ncbi Taste-immunosuppression engram: reinforcement and extinction
    Maj Britt Niemi
    Institute for Behavioral Sciences, ETH Zurich, Zurich, Switzerland
    J Neuroimmunol 188:74-9. 2007
    ..Here we demonstrate that the saccharin taste can be associated with the immunosuppressive agent cyclosporine A, and that such taste-immune associative ..
  90. pmc Taste solution preferences of C57BL/6J and 129X1/SvJ mice: influence of age, sex, and diet
    Michael G Tordoff
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Chem Senses 32:655-71. 2007
    ..given a series of 48-h 2-bottle tests with a choice between water and one of the following taste solutions: 2 mM saccharin, 5 mM citric acid, 30 microM quinine hydrochloride, 75 mM sodium chloride (NaCl), 10 mM inosine monophosphate (..
  91. pmc Appetitive sensitization by amphetamine does not reduce its ability to produce conditioned taste aversion to saccharin
    John Scott-Railton
    Department of Psychiatry, The University of Chicago, 5841 S Maryland Avenue, MC 3077, Chicago, IL 60637, USA
    Behav Brain Res 175:305-14. 2006
    ..It is concluded that amphetamine sensitization alone does not modulate this drug's ability to produce CTA. Implications of these findings for anatomically based associative and non-associative models of CTA and the US-PEE are discussed...
  92. ncbi Ethanol intake in the juvenile, adolescent, and adult rat: effects of age and prior exposure to ethanol
    Eric M Truxell
    Department of Psychology, Binghamton University, Binghamton, New York 13902 6000, USA
    Alcohol Clin Exp Res 31:755-65. 2007
    ..How this initial experience with ethanol affected subsequent affinity for ethanol intake was later assessed using 2-bottle choice preference tests...
  93. ncbi Acquisition of i.v. cocaine self-administration in adolescent and adult male rats selectively bred for high and low saccharin intake
    Jennifer L Perry
    University of Kentucky, BBSRB, Room 248F, 741 S Limestone, Lexington, KY 40536 0509, United States
    Physiol Behav 91:126-33. 2007
    Adolescence and excessive intake of saccharin have each been previously associated with enhanced vulnerability to drug abuse...
  94. ncbi Effects of central and basolateral amygdala lesions on conditioned taste aversion and latent inhibition
    Justin St Andre
    Department of Psychology, University of Illinois at Chicago, Chicago, IL 60607, USA
    Behav Neurosci 121:90-9. 2007
    ..The pattern of results suggests that the CTA deficit in rats with BLA lesions may be a secondary consequence of a disruption of perceived stimulus novelty...
  95. pmc Conditioned preference for sweet stimuli in OLETF rat: effects of food deprivation
    Bart C De Jonghe
    Dept of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State Univ, University Park, PA 16802, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1819-27. 2007
    ..54% for OLETF and LETO rats, respectively) during the test. When a noncaloric saccharin solution is used as US, OLETF rats show a higher preference for the saccharin-associated flavor relative to LETO ..
  96. ncbi Forebrain structures specifically activated by conditioned taste aversion
    G Ferreira
    Laboratoire Comportement, Neurobiologie et Adaptation, UMR 6175 INRA CNRS Universite de Tours Haras Nationaux, Nouzilly, France
    Behav Neurosci 120:952-62. 2006
    ..No significant variation of Fos expression was measured in the perirhinal cortex. Several forebrain areas may be sites of taste-malaise convergence during CTA acquisition depending on the strength of the aversion...
  97. ncbi Age and interstimulus interval in forward and backward long-trace taste-aversion conditioning
    Eli Minnier
    Susquehanna University, USA
    Percept Mot Skills 105:1223-6. 2007
    ..As reported with forward conditioning, stress may alter metabolic rate such that the intervals at which associations can be formed are shortened...
  98. ncbi Effects of neuropeptide Y on feeding microstructure: dissociation of appetitive and consummatory actions
    John Paul Baird
    Department of Psychology, Amherst College, Amherst, MA 01002, USA
    Behav Neurosci 120:937-51. 2006
    The effects of intracerebroventricular application of Neuropeptide Y (NPY) on licking microstructure for sucrose, saccharin, and water solutions were evaluated. In Experiment 1, NPY increased meal size for three sucrose concentrations (0...
  99. ncbi Effects of alcohol and saccharin deprivations on concurrent ethanol and saccharin operant self-administration by alcohol-preferring (P) rats
    Jamie E Toalston
    Department of Psychology, Purdue School of Science, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Alcohol 42:277-84. 2008
    ..The objective of the present study was to determine the effects of ethanol and saccharin (SACC) deprivations on operant oral self-administration...
  100. ncbi Familiarization and cross-familiarization of wheel running and LiCl in conditioned taste aversion
    Sadahiko Nakajima
    Psychology Section, Department of Integrated Psychological Science, Kwansei Gakuin University, Nishinomiya 662 8501, Japan
    Physiol Behav 88:1-11. 2006
    ..This US crossover effect suggests the possibility that wheel running and LiCl injection share a common or similar physiological mechanism in inducing taste aversion...
  101. ncbi Nicotine-induced conditioned taste aversion in the rat: effects of ethanol
    Agnieszka Korkosz
    Department of Pharmacology, Institute of Psychiatry and Neurology, 9 Sobieskiego St, PL 02957, Warsaw, Poland
    Eur J Pharmacol 537:99-105. 2006
    ..Wistar rats were trained to associate nicotine injections with a novel tasting fluid (0.1% saccharin) in the conditioned taste aversion procedure. Nicotine (0.3 mg/kg, s.c...

Research Grants63

  1. Mechanisms of comorbidity between epilepsy and depression
    Andrey M Mazarati; Fiscal Year: 2013
    ..equivalents of depression - despair, as examined in the forced swim test, and anhedonia, analyzed using saccharin consumption taste preference test...
  2. Neurobiological basis of Depression as a Comorbidity in Epilepsy
    Andrey M Mazarati; Fiscal Year: 2010
    ..tests (forced swim test to examine an ability to adapt active strategies in inescapable stressful situation;saccharin intake to examine an ability to experience pleasure;food intake to examine appetite), biochemical assays of ..
  3. Genetic controls of mineral consumption
    Michael G Tordoff; Fiscal Year: 2013
    ..lines that isolate a QTL on Chr 17 that has impressively high LOD scores for CaCl2 preference (LOD = 45) and saccharin preference (LOD = 100)...
  4. Uncertainty and stimulant self-administration
    PAUL R VEZINA; Fiscal Year: 2013
    ..following exposure to a number of drugs and cross-sensitization between drugs and non-drug reinforcers such as saccharin has been reported...
  5. Hedonic vs. Metabolic Processing by the Nucleus Accumbens
    James Edgar McCutcheon; Fiscal Year: 2013
    ..For Aims 1 and 2, sucrose will be compared to the non-caloric sweetener saccharin. In Aim 3, intragastric infu- sions of nutrient will be paired with intraoral infusions of flavored saccharin...
  6. Development of Age-Appropriate Fast Disintegrating Pediatric Granules and Tablets
    MOJI ADEYEYE; Fiscal Year: 2009
    ..In Specific Aim 1, interaction of drugs with excipients such as sweeteners (e.g., saccharin, sucralose, sucrose) and diluents/binder (e.g...
  7. Fat, sweet taste, and cocaine reinforcement in obese and lean Zucker rats
    Kevin B Freeman; Fiscal Year: 2012
    ..investigate the relative reinforcing efficacy of sweet taste, a component of sugar reinforcement, by comparing saccharin reward in Ob and Le rats in Specific Aim 2...
  8. GABAergic Mechanisms of Comorbid Alcohol and Nicotine Dependence
    Kelly P Cosgrove; Fiscal Year: 2013
    ..Group 4, a control condition, will self-administer saccharin for 24 weeks and will be imaged at 1 day, 8 days and 12 weeks after termination of saccharin...
  9. Characterizing Alpha5* Nicotinic Receptors in Alcohol and Nicotine Co-Dependence
    Raymond L White; Fiscal Year: 2010
    ..drinking model we developed that enables ethanol and nicotine to be consumed together without the need for saccharin. In the second part of the project, we will combine clinical studies and genetics to determine whether genetic ..
  10. Effects of Clopazine and haloperidol on responding
    Danielle Gulick; Fiscal Year: 2010
    ..determine whether the hamster shows a higher motivation to consume alcohol and isocaloric sucrose, compared to saccharin, water, and food, in an OSA paradigm;and (4) to determine whether HAL, but not CLOZ, will decrease the ..
  11. ENVIRONMENTAL AND PHARMACOLOGICAL CONTROL OF DRUG ABUSE
    Marilyn Carroll; Fiscal Year: 2000
    ..Chronic access to cocaine will be restored, and behavior maintained by food, a glucose and saccharin (G+S) solution will be measured when cocaine access is terminated...
  12. Neural Mechanisms fo Extinction and Spontaneous Recovery
    G Mickley; Fiscal Year: 2009
    ..Research design and methods: We will create CTAs in rats by pairing the taste of saccharin (SAC;CS) with an i.p...
  13. Role of Orexin in Conditioned Responding for Saccharin: Implications for Obesity
    Angie Cason; Fiscal Year: 2013
    ..studies outlined in this proposal will use a combination of optogenetic and pharmacological techniques to investigate the specific orexin circuitry that mediates conditioned responding to sweets during cue-elicited saccharin-seeking.
  14. NEUROPHARMACOLOGY OF ETHANOL REINFORCEMENT
    George Koob; Fiscal Year: 2002
    ..deprived male and female rats will be trained to self-administer ethanol in daily 30 minute sessions using a saccharin fade out procedure...
  15. SUCROSE AND/OR FAT INGESTION EFFECT ON OPIOIDS
    Allen Levine; Fiscal Year: 2003
    ..We propose four sets of studies to test this hypothesis: Do palatable foods or solutions (containing sucrose, saccharin and/or fat) result in an increase in gene expression of opioid peptides in brain sites known to be involved in ..
  16. Assessing Impulsivity in High Alcohol Preferring Mice
    Brandon Oberlin; Fiscal Year: 2009
    ..Our general hypothesis is that the HAP mice will show higher impulsivity with saccharin rewards than the Low Alcohol Preferring mice...
  17. NONCARIOGENIC INTENSE NATURAL SWEETNERS
    ALAN KINGHORN; Fiscal Year: 1993
    ..three substances approved for use in the United States as high-intensity (non-nutritive) sweeteners, namely, saccharin and aspartame, and acesulfame K, which are used in place of sucrose in foods, beverages, and medicines...
  18. BRAIN-PITUITARY-ADRENAL INTERRELATIONSHIPS
    Mary Dallman; Fiscal Year: 2007
    ..Sucrose, but not saccharin to drink will reduce activity in the recruited central stress response network...
  19. ORALLY DELIVERED COCAINE AS A REINFORCER
    RICHARD MEISCH; Fiscal Year: 1992
    ..the available liquid -- a cocaine solution, the vehicle (water), or a solution containing a non-drug reinforcer (saccharin), (2) the amount of behavior subjects must emit prior to drug delivery (specifically, the size of a fixed-ratio ..
  20. NALTREXONE/ETHANOL INTERACTION--PHARMACOLOGICAL ANALYSIS
    Gail Winger; Fiscal Year: 1999
    ..a number of opioid antagonist and lithium will be evaluated in these monkeys and in monkeys drinking sucrose or saccharin in preference to water...
  21. Drugs of Abuse, Gender Differences, and Protection by Sweets
    Angie Cason; Fiscal Year: 2010
    DESCRIPTION (provided by candidate): Rats will suppress intake of a saccharin solution that predicts either the passive or the active (i.e., self-) administration of a drug of abuse...
  22. ADOLESCENT ETOH WITHDRAWAL: EFFECT ON ADULT RESPONSE
    Danielle Graham; Fiscal Year: 2001
    ..During conditioning animals will receive 15 minutes unlimited access to a .15% saccharin solution. Following the removal of the saccharin bottles, all animals will receive a 2...
  23. NEUROBEHAVIORAL TOXICITY FROM ALUMINUM
    Robert Yokel; Fiscal Year: 1980
    ..the rabbit in a classical conditioning experimental paradigm, magnitude and retention of an acquired aversion to saccharin solution which has been paired with aversive rotation in the conditioned taste aversion paradigm, extent and ..
  24. DeltaFosB and Reward Comparison in Mice
    CHRISTOPHER FREET; Fiscal Year: 2009
    ..of elevated AFosB on preference for natural rewards by evaluating two-bottle preference tests for a rewarding (saccharin), neutral (NaCI), and aversive (quinine) taste stimuli...
  25. GABA RECEPTOR MECHANISMS IN ALCOHOL REINFORCEMENT
    HARRY JUNE; Fiscal Year: 2001
    ..e., saccharin), or similar post-ingestional caloric properties (i.e., sucrose)...
  26. Progesterone as a Treatment for Cocaine Abuse in Rats with Differing Vulnerabilit
    JUSTIN ANKER; Fiscal Year: 2009
    ..These populations include: male vs. female, high vs. low impulsive, and high vs. low saccharin preferring rats...
  27. Neural Substrates of Drug-Induced Reward Devaluation
    ANNE BALDWIN; Fiscal Year: 2005
    Rats will suppress intake of a saccharin solution that predicts either passively administered or self-administered drugs of abuse...
  28. CELL CELL COMMUNICATION IN CARCINOGENESIS
    James Trosko; Fiscal Year: 1999
    ..Based on (a) the demonstration that many chemical tumor promoters (i. e., TPA, DDT, TCDD, saccharin, phenobarbital, etc...
  29. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2009
    ..It will advance our understanding of the basic mechanisms involved in the development of food preferences and may provide insights into the clinical treatment of overeating and obesity. ..
  30. Alcohol Modulation of Brain Reward Pathways
    Allen Levine; Fiscal Year: 2004
    ..Rather, central administered ethanol resulted in conditioned taste preference acceptance when paired with saccharin intake...
  31. COCAINE ABUSE: EFFECTS ON BRAIN SEXUAL DIFFERENTIATION
    ROBERT MC GIVERN; Fiscal Year: 1992
    ..Behaviors to be studied will include masculine and feminine reproductive behavior potentials, scent marking and saccharin preference...
  32. Operant Responding in Opioid-Deficient Mice
    Malcolm Low; Fiscal Year: 2004
    ..The primary behavioral task to assess reward is operant responding for food, saccharin, or morphine...
  33. ALCOHOL APPETITE--A NUTRIENT CONDITIONING ANALYSIS
    Karen Ackroff; Fiscal Year: 2001
    ..It will advance our basic knowledge of the psychobiology of alcohol appetite and may provide practical benefits for controlling alcohol consumption in humans. ..
  34. TASTE MATCHING--GUSTATORY EQUIVALENCE CLASSES
    Paul Breslin; Fiscal Year: 2001
    ..or more of the four qualities, then it should be possible to match compounds with complex tastes, like that of saccharin which is described as sweet and bitter, with mixtures of compounds that are more purely sweet and bitter...
  35. DRUGS OF ABUSE, REWARD COMPARISON, AND THE THALAMUS
    Patricia Sue Grigson; Fiscal Year: 2010
    Rats avoid intake of a saccharin conditioned stimulus (CS) when paired with a drug of abuse (LeMagnen, 1969;for reviews, see Gamzu, Vincent, &Boff, 1985;Goudie, 1987;Hunt &Amit, 1987)...
  36. EARLY HUSBANDRY INFLUENCES ON ADULT PHENOTYPE
    MICHAEL TORDOFF; Fiscal Year: 2009
    ..The results will lead to better environmental controls in future work and, asa direct consequence, easierand more rapid progress with genetic analyses. ..
  37. Vulnerability to Drug Abuse and Treatment Efficacy: Animal Models
    Marilyn E Carroll; Fiscal Year: 2010
    ..The proposed research will show how enhanced drug-seeking behavior in vulnerable phenotypes can be reduced at the most critical, vulnerable phases of drug abuse through behavioral and pharmacological interventions. ..
  38. GUSTATORY THALAMUS AND TASTE GUIDED BEHAVIOR
    STEPHEN REILLY; Fiscal Year: 2004
    ..The results of the research proposed in this application will significantly enhance our understanding of the information processing role(s) of the thalamic taste area of the rat. ..
  39. Prenatal ethanol, social behavior, and prefrontal cortex
    Derek Hamilton; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  40. MOLECULAR MECHANISMS OF CONDITIONED TASTE AVERSION
    THOMAS HOUPT; Fiscal Year: 2004
    ..These experiments will contribute to an understanding of the neural pathways and molecular mechanisms underlying changes in food preferences that occur in eating disorders such as obesity and anorexia nervosa. ..
  41. Behavioral and Neural Effects of High Magnetic Fields
    THOMAS HOUPT; Fiscal Year: 2009
    ..behavioral level, magnetic field exposure induced a conditioned taste aversion after pairing with the taste of saccharin. At the neural level, the same exposure induced specific and significant c- Fos , a marker of neuronal ..
  42. Is ethanol rewarding or aversive?
    Chuang Liu; Fiscal Year: 2008
    ..experiments: (I) Use intake measures and ultrasonic vocalizations to test whether ethanol-induced suppression of saccharin intake is mediated by rewarding or aversive properties...
  43. Diet, Obesity and Stress
    Yvonne Ulrich Lai; Fiscal Year: 2005
    ..abstract_text> ..
  44. NEUROCHEMISTRY OF ALCOHOL PREFERENCE
    Nicholas Grahame; Fiscal Year: 2003
    ..Overall, by increasing basic knowledge of neural, genetic, and behavioral mechanisms underlying excessive drinking, these studies may further development of drug-based treatments for alcoholism. ..
  45. PERIPHERAL GUSTATORY PROCESSING
    MARION ELIZABETH FRANK; Fiscal Year: 2010
    ..Also, elimination of taste disorders would improve the quality of life that depends on enjoyment of food and drink, a universal human need contributing much to human sociality. ..
  46. Gene expression associated with the CNS reinforcing act*
    ZACHARY RODD HENRICKS; Fiscal Year: 2003
    ..The results of the proposed project will provide valuable information on neuronal systems and receptors within the extended amygdala involved in mediating the rewarding properties of alcohol. ..
  47. CENTRAL GUSTATORY ELECTROPHYSIOLOGY IN MICE
    Stuart McCaughey; Fiscal Year: 2005
    ..abstract_text> ..
  48. BRAIN GALANIN RECEPTORS AND EPILEPSY
    Andrey Mazarati; Fiscal Year: 2006
    ..abstract_text> ..
  49. Human Salty and Bitter Taste Mechanisms
    MARION FRANK; Fiscal Year: 2007
    ..Greater understanding of gustatory perceptual processing in humans may lead to better management of taste disorders such as distressful salty-bitter dysgeusias and excessive salt intake. ..
  50. Neural Basis of Ethanol Sensitization/Drinking in Mice
    Nicholas Grahame; Fiscal Year: 2008
    ..The hypothesis is that associative forms of neural and behavioral plasticity underlie both the acquisition of excessive drinking and LMS, and that the amygdala may lie at the heart of this interaction. ..
  51. IBANGS Annual Meeting support
    John Crabbe; Fiscal Year: 2005
    ..This young society represents an opportunity to attract a core group of young investigators to alcohol research during their formative years. ..
  52. GENETICS OF ALCOHOL RELATED INGESTIVE BEHAVIORS IN MICE
    Alexander Bachmanov; Fiscal Year: 2007
    ..Through these three aims, we intend to isolate loci involved in ethanol preference, identify candidate genes for these loci in mice, and specify their human orthologs. ..
  53. BIOBEHAVIORAL MECHANISMS OF HIGH-FAT DIET HYPERPHAGIA
    Zoe Warwick; Fiscal Year: 2005
    ..An increased understanding of the underlying determinants of high-fat diet hyperphagia has the potential to inform and positively impact clinical and public health strategies aimed at promoting a healthier level of fat intake. ..
  54. Metabolic Changes During Aging: A Role for Melatonin
    DENNIS RASMUSSEN; Fiscal Year: 2003
    ....
  55. Role of Amygdala in Ethanol Reinforcement and Anxiety
    Amanda Roberts; Fiscal Year: 2005
    ..This INIA makes use of several Genetic Animal Models Core Components, relates well to other INIA UOls, and also will provide input to the Gene Expression, Imaging and the Bioinformatics Cores. ..
  56. A Cross-Cultural Longitudinal Assessment of FASD (U24)
    Tatiana Foroud; Fiscal Year: 2005
    ..abstract_text> ..
  57. Bupropion and Secondary Motivational Effects of Nicotine
    ANTHONY RAUHUT; Fiscal Year: 2005
    ..S. population to 12% and 16%, accordingly. ..
  58. ADOLESCENT ETOH EXPOSURE: EFFECT ON ADULT ETOH RESPONSE
    JAIME DIAZ GRANADOS; Fiscal Year: 2003
    ..abstract_text> ..
  59. Chronic stress intensifies incentive relativity
    Mary Dallman; Fiscal Year: 2006
    ..abstract_text> ..
  60. MECHANISMS OF PERIPHERAL FAT DETECTION
    Timothy A Gilbertson; Fiscal Year: 2010
    ..abstract_text> ..
  61. Naltrexone sensitivity during responding for ethanol.
    Keith Williams; Fiscal Year: 2006
    ..These studies should suggest behavioral and environmental factors that may enhance or attenuate NTX's use in treating human alcoholism [unreadable] [unreadable]..
  62. PSYCHOPHYSICAL EVALUATION OF TASTE FUNCTION
    Alan C Spector; Fiscal Year: 2010
    ..These experiments will psychophysically define the contribution of an important class of taste receptors to normal gustatory function in the mouse model, which is becoming widely adopted for study of mammalian chemosensory processes. ..
  63. MECHANISMS OF PERIPHERAL FAT DETECTION
    TIMOTHY GILBERTSON; Fiscal Year: 2008
    ..abstract_text> ..