Summary: Inorganic salts of sulfuric acid.

Top Publications

  1. ncbi Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica
    Jing Wang
    Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China
    Int J Biol Macromol 42:127-32. 2008
  2. ncbi Structure of a fucoidan from the brown seaweed Fucus evanescens C.Ag
    Maria I Bilan
    N D Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninskii prosp 47, 119991 Moscow, Russian Federation
    Carbohydr Res 337:719-30. 2002
  3. pmc Chemical structures and bioactivities of sulfated polysaccharides from marine algae
    Guangling Jiao
    National Research Council Canada, Institute for Marine Biosciences, Halifax, NS, B3H 3Z1, Canada
    Mar Drugs 9:196-223. 2011
  4. ncbi A marine microbial consortium apparently mediating anaerobic oxidation of methane
    A Boetius
    Max Planck Institute for Marine Microbiology, Bremen, Germany
    Nature 407:623-6. 2000
  5. ncbi Reverse methanogenesis: testing the hypothesis with environmental genomics
    Steven J Hallam
    Monterey Bay Aquarium Research Institute, Moss Landing, CA 95064, USA
    Science 305:1457-62. 2004
  6. ncbi The ecology and biotechnology of sulphate-reducing bacteria
    Gerard Muyzer
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Nat Rev Microbiol 6:441-54. 2008
  7. ncbi A preponderantly 4-sulfated, 3-linked galactan from the green alga Codium isthmocladum
    Eduardo H C Farias
    Laboratório de Biotecnologia de Polímeros Naturais, Departamento de Bioquimica, Universidade Federal do Rio Grande do Norte, Natal, RN, 59072 970, Brazil
    Glycobiology 18:250-9. 2008
  8. ncbi Focus on antivirally active sulfated polysaccharides: from structure-activity analysis to clinical evaluation
    Tuhin Ghosh
    Department of Chemistry, Natural Products Laboratory, University of Burdwan, WB 713 104, India
    Glycobiology 19:2-15. 2009
  9. ncbi MicroRNA395 mediates regulation of sulfate accumulation and allocation in Arabidopsis thaliana
    Gang Liang
    Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming, Yunnan 650223, China
    Plant J 62:1046-57. 2010
  10. pmc Nutritional homeostasis in batch and steady-state culture of yeast
    Alok J Saldanha
    Department of Genetics, Stanford University Medical School, Stanford, CA 94305, USA
    Mol Biol Cell 15:4089-104. 2004

Detail Information

Publications354 found, 100 shown here

  1. ncbi Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica
    Jing Wang
    Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China
    Int J Biol Macromol 42:127-32. 2008
    ..Available data obtained with in vitro models suggested that the ratio of sulfate content/fucose was an effective indicator to antioxidant activity of the samples...
  2. ncbi Structure of a fucoidan from the brown seaweed Fucus evanescens C.Ag
    Maria I Bilan
    N D Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninskii prosp 47, 119991 Moscow, Russian Federation
    Carbohydr Res 337:719-30. 2002
    ..Additional sulfate occupies position 4 in a part of 3-linked fucose residues, whereas a part of the remaining hydroxyl groups is randomly acetylated...
  3. pmc Chemical structures and bioactivities of sulfated polysaccharides from marine algae
    Guangling Jiao
    National Research Council Canada, Institute for Marine Biosciences, Halifax, NS, B3H 3Z1, Canada
    Mar Drugs 9:196-223. 2011
    ..It will then review the recent findings on the anticoagulant/antithrombotic, antiviral, immuno-inflammatory, antilipidemic and antioxidant activities of sulfated polysaccharides and their potential for therapeutic application...
  4. ncbi A marine microbial consortium apparently mediating anaerobic oxidation of methane
    A Boetius
    Max Planck Institute for Marine Microbiology, Bremen, Germany
    Nature 407:623-6. 2000
    ..These aggregates were abundant in gas-hydrate-rich sediments with extremely high rates of methane-based sulphate reduction, and apparently mediate anaerobic oxidation of methane...
  5. ncbi Reverse methanogenesis: testing the hypothesis with environmental genomics
    Steven J Hallam
    Monterey Bay Aquarium Research Institute, Moss Landing, CA 95064, USA
    Science 305:1457-62. 2004
    ..These genome-based observations support previous hypotheses and provide an informed foundation for metabolic modeling of anaerobic methane oxidation...
  6. ncbi The ecology and biotechnology of sulphate-reducing bacteria
    Gerard Muyzer
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Nat Rev Microbiol 6:441-54. 2008
    ..Although SRB have been studied for more than a century, it is only with the recent emergence of new molecular biological and genomic techniques that we have begun to obtain detailed information on their way of life...
  7. ncbi A preponderantly 4-sulfated, 3-linked galactan from the green alga Codium isthmocladum
    Eduardo H C Farias
    Laboratório de Biotecnologia de Polímeros Naturais, Departamento de Bioquimica, Universidade Federal do Rio Grande do Norte, Natal, RN, 59072 970, Brazil
    Glycobiology 18:250-9. 2008
    ..A comparison of sulfated galactans from different marine taxonomic groups revealed similar backbones of 3-beta-D-Galp-1...
  8. ncbi Focus on antivirally active sulfated polysaccharides: from structure-activity analysis to clinical evaluation
    Tuhin Ghosh
    Department of Chemistry, Natural Products Laboratory, University of Burdwan, WB 713 104, India
    Glycobiology 19:2-15. 2009
    ..This review summarizes experimental evidence indicating that sulfated polysaccharides might become increasingly important in drug development for the prevention of sexually transmitted diseases in the near future...
  9. ncbi MicroRNA395 mediates regulation of sulfate accumulation and allocation in Arabidopsis thaliana
    Gang Liang
    Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming, Yunnan 650223, China
    Plant J 62:1046-57. 2010
    ..Our research showed that miR395 is involved in the regulation of sulfate accumulation and allocation by targeting APS genes and SULTR2;1, respectively...
  10. pmc Nutritional homeostasis in batch and steady-state culture of yeast
    Alok J Saldanha
    Department of Genetics, Stanford University Medical School, Stanford, CA 94305, USA
    Mol Biol Cell 15:4089-104. 2004
  11. ncbi Novel microbial communities of the Haakon Mosby mud volcano and their role as a methane sink
    Helge Niemann
    Max Planck Institute for Marine Microbiology, 28359 Bremen, Germany
    Nature 443:854-8. 2006
    ..This mechanism limits the capacity of the microbial methane filter at active marine mud volcanoes to <40% of the total flux...
  12. pmc Comparative analysis of methane-oxidizing archaea and sulfate-reducing bacteria in anoxic marine sediments
    V J Orphan
    Monterey Bay Aquarium Research Institute, 7700 Sandholdt Rd, P O Box 628, Moss Landing, California 95039
    Appl Environ Microbiol 67:1922-34. 2001
  13. ncbi Sulfated seaweed polysaccharides as antiviral agents
    Elsa B Damonte
    Virologia, Departamento de Quimica Biologica, CIHIDECAR CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellon 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina
    Curr Med Chem 11:2399-419. 2004
  14. ncbi Methane as fuel for anaerobic microorganisms
    Rudolf K Thauer
    Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Strasse, D 35043 Marburg, Germany
    Ann N Y Acad Sci 1125:158-70. 2008
    ..The first step in methane oxidation is most likely the exergonic formation of 2-methylsuccinate from fumarate and methane catalyzed by a glycine-radical enzyme...
  15. pmc Drug targets in mycobacterial sulfur metabolism
    Devayani P Bhave
    Chemical Biology Ph D Program, University of Michigan, Ann Arbor, Michigan, 48109 2216, USA
    Infect Disord Drug Targets 7:140-58. 2007
    ..In this light, we also summarize recent progress in the development of inhibitors of sulfur metabolism enzymes...
  16. ncbi A disaccharide repeat unit is the major structure in fucoidans from two species of brown algae
    L Chevolot
    Laboratoire de Recherches sur les Macromolecules, Unité de Recherche Marine 2 et Unité Mixte de Recherche CNRS 7540, Universite Paris Nord, Villetaneuse, France
    Carbohydr Res 330:529-35. 2001
    ..The fraction LMWF has in vitro anticoagulant activity, indicating that the above structure may be partly responsible for biological activity in the native fucoidan...
  17. ncbi Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats
    Elisabeth Wenzel
    German Research Center for Food Chemistry, Garching, Germany
    Mol Nutr Food Res 49:482-94. 2005
    ..The lack of effect on the chemopreventive parameters is probably due to the formation of various resveratrol conjugates reducing its bioavailability in the rat...
  18. pmc Dendritic polyglycerol sulfates as multivalent inhibitors of inflammation
    Jens Dernedde
    Zentralinstitut für Laboratoriumsmedizin und Pathobiochemie, Charite Universitatsmedizin, 12203 Berlin, Germany
    Proc Natl Acad Sci U S A 107:19679-84. 2010
    ..Based on this rationale we investigated synthetic dendritic polyglycerol sulfates (dPGS) as macromolecular inhibitors that operate via a multivalent binding mechanism mimicking naturally ..
  19. ncbi Regulation of sulfate uptake and assimilation--the same or not the same?
    Jean Claude Davidian
    Unite Mixte de Recherche, Biochimie et Physiologie Moleculaire des Plantes, Montpellier SupAgro CNRS INRA UM2, 2 Place Pierre Viala, 34060 Montpellier Cedex 2, France
    Mol Plant 3:314-25. 2010
    ..Here, we review the current knowledge on regulation of these processes, with special attention given to similarities and differences...
  20. ncbi Structure and mechanism of an inverting alkylsulfatase from Pseudomonas sp. DSM6611 specific for secondary alkyl sulfates
    Tanja Knaus
    Institute of Biochemistry, Graz University of Technology, Graz, Austria
    FEBS J 279:4374-84. 2012
    ..from Pseudomonas aeruginosa (SdsA1), Pisa1 showed a preference for secondary rather than primary alkyl sulfates, and enantioselectively hydrolyzed the (R)-enantiomer of rac-2-octyl sulfate, yielding (S)-2-octanol with ..
  21. pmc Chondroitin-4-sulfation negatively regulates axonal guidance and growth
    Hang Wang
    Developmental Neurobiology Section, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 121:3083-91. 2008
    ..Thus, our findings show that specific sulfation along the carbohydrate backbone carries instructions to regulate neuronal function...
  22. ncbi Desulfonauticus submarinus gen. nov., sp. nov., a novel sulfate-reducing bacterium isolated from a deep-sea hydrothermal vent
    Carine Audiffrin
    IRD, UR 101 Extrêmophiles, IFR BAIM, Universités de Provence et de la Méditerranée, ESIL, Case 925, 163 avenue de la Méditerranée, 13288 Marseille Cedex 09, France
    Int J Syst Evol Microbiol 53:1585-90. 2003
    ..nov., sp. nov...
  23. ncbi A cultured greigite-producing magnetotactic bacterium in a novel group of sulfate-reducing bacteria
    Christopher T Lefèvre
    Laboratoire de Bioenergetique Cellulaire, UMR 6191, Commissariat à l Energie Atomique Cadarache, Direction des Sciences du Vivant, Institut de Biologie Environnementale et Biotechnologie, Saint Paul lez Durance, France
    Science 334:1720-3. 2011
    ..Genomic analysis of BW-1 reveals the presence of two different magnetosome gene clusters, suggesting that one may be responsible for greigite biomineralization and the other for magnetite...
  24. ncbi Evaluating the possible genotoxic, mutagenic and tumor cell proliferation-inhibition effects of a non-anticoagulant, but antithrombotic algal heterofucan
    Jailma Almeida-Lima
    Departamento de Bioquimica, Universidade Federal do Rio Grande do Norte, Av Senador Salgado Filho, Lagoa Nova, CEP 59072 970, Natal, Brazil
    J Appl Toxicol 30:708-15. 2010
    ..In conclusion, this study indicates that the S. schröederi fucan A was not found to be genotoxic or mutagenic compound; thus it could be used in new antithrombotic drug development...
  25. ncbi Control of sulfur partitioning between primary and secondary metabolism
    Sarah G Mugford
    Department of Metabolic Biology, John Innes Centre, Norwich NR4 7UH, UK
    Plant J 65:96-105. 2011
    ..Thus, at least in Arabidopsis, the interplay between APS reductase and APS kinase is important for sulfur partitioning between the primary and secondary metabolism...
  26. ncbi Crystal structure of ATP sulfurylase from Penicillium chrysogenum: insights into the allosteric regulation of sulfate assimilation
    I J MacRae
    Section of Molecular and Cellular Biology and Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, USA
    Biochemistry 40:6795-804. 2001
    ..On the other hand, a surface "trench" links each catalytic site in one triad with an allosteric site in the other triad. This trench may be a vestigial feature of a bifunctional ("PAPS synthetase") ancestor of fungal ATP sulfurylase...
  27. ncbi Sulfation of thyroid hormone and dopamine during human development: ontogeny of phenol sulfotransferases and arylsulfatase in liver, lung, and brain
    K Richard
    Department of Obstetrics and Gynecology, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom DD1 9SY
    J Clin Endocrinol Metab 86:2734-42. 2001
  28. ncbi Thermodesulfobacterium hydrogeniphilum sp. nov., a thermophilic, chemolithoautotrophic, sulfate-reducing bacterium isolated from a deep-sea hydrothermal vent at Guaymas Basin, and emendation of the genus Thermodesulfobacterium
    Christian Jeanthon
    UMR 6539, Centre National de la Recherche Scientifique and Université de Bretagne Occidentale, Institut Universitaire Europeen de la Mer, Plouzane, France
    Int J Syst Evol Microbiol 52:765-72. 2002
    ..nov. The type strain is SL6T (= DSM 14290T = JCM 11239T). Because of the phenotypic characteristics of the novel species, it is also proposed that the description of the genus Thermodesulfobacterium requires emendation...
  29. pmc The regulation of sulfur metabolism in Mycobacterium tuberculosis
    Stavroula K Hatzios
    Department of Chemistry, University of California, Berkeley, Berkeley, California, United States of America
    PLoS Pathog 7:e1002036. 2011
    ..From this global analysis, we have identified a subset of sulfur-metabolizing enzymes that are sensitive to multiple regulatory cues and may be strong candidates for therapeutic intervention...
  30. pmc MET4, a leucine zipper protein, and centromere-binding factor 1 are both required for transcriptional activation of sulfur metabolism in Saccharomyces cerevisiae
    D Thomas
    Laboratoire d Enzymologie due Centre National de la Recherche Scientifique, Gif sur Yvette, France
    Mol Cell Biol 12:1719-27. 1992
    ..This regulation was shown to depend on both MET4 and CBF1. The obtained results suggest that the binding of CBF1 to its cognate sequences increases the ability of MET4 to stimulate transcription of the MET genes...
  31. ncbi The three desulfoglucosinolate sulfotransferase proteins in Arabidopsis have different substrate specificities and are differentially expressed
    Marion Klein
    Institute for Botany, University of Hannover, Germany
    FEBS J 273:122-36. 2006
    ..High (500 microM) and low (50 microM) sulfate concentrations in the medium did not influence the levels of expression...
  32. ncbi Plant sulfate assimilation genes: redundancy versus specialization
    Stanislav Kopriva
    John Innes Centre, Norwich, NR4 7UH, UK
    Plant Cell Rep 28:1769-80. 2009
    ..We will also compare the genomic organization of sulfate assimilation in the model plant Arabidopsis thaliana with other plant species to find common and species-specific features of the pathway...
  33. ncbi The biology and enzymology of protein tyrosine O-sulfation
    Kevin L Moore
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, The Department of Medicine, University of Oklahoma Health Sciences Center, USA
    J Biol Chem 278:24243-6. 2003
  34. pmc Candidate sulfonated and sulfated topical microbicides: comparison of anti-human immunodeficiency virus activities and mechanisms of action
    Irini A Scordi-Bello
    Department of Medicine, Mount Sinai School of Medicine, Box 1090, New York, NY 10029, USA
    Antimicrob Agents Chemother 49:3607-15. 2005
    ..When mixed with cervicovaginal lavage fluid, SPs maintain inhibitory activity at concentrations achievable in formulations...
  35. ncbi Bacterial diversity and activity along a salinity gradient in soda lakes of the Kulunda Steppe (Altai, Russia)
    Mirjam J Foti
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Extremophiles 12:133-45. 2008
    ..Furthermore, the increase of sodium carbonate/bicarbonate seemed to affect the composition of the microbial community in soda lakes, but not the rate of sulfate reduction...
  36. pmc Mitosomes in Entamoeba histolytica contain a sulfate activation pathway
    Fumika Mi-ichi
    Department of Parasitology, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    Proc Natl Acad Sci U S A 106:21731-6. 2009
    ..These results suggest that sulfate activation is the major function of mitosomes in E. histolytica and that E. histolytica mitosomes represent a unique mitochondrion-related organelle with remarkable diversity...
  37. ncbi Antioxidant activity of different sulfate content derivatives of polysaccharide extracted from Ulva pertusa (Chlorophyta) in vitro
    Huimin Qi
    Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China
    Int J Biol Macromol 37:195-9. 2005
    ..Thirdly, HU4 (sulfate content, 30.8%) and HU5 (sulfate content, 32.8%) showed more pronounce chelating ability on ferrous ion at high concentration than other samples...
  38. pmc Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins
    Lianchun Wang
    Department of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0687, USA
    J Clin Invest 110:127-36. 2002
    ..Such analogs may prove useful as therapeutically effective inhibitors of inflammation...
  39. ncbi Long-term inhalable particles and other air pollutants related to mortality in nonsmokers
    D E Abbey
    Loma Linda University, Loma Linda, California 92350, USA
    Am J Respir Crit Care Med 159:373-82. 1999
    ..inhalable particles less than 10 microm in diameter (PM10) (1973- 1992) and other air pollutants-total suspended sulfates, sulfur dioxide, ozone (O3), and nitrogen dioxide-were related to 1977-1992 mortality in a cohort of 6,338 ..
  40. ncbi Sulfation patterns of glycosaminoglycans encode molecular recognition and activity
    Cristal I Gama
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Nat Chem Biol 2:467-73. 2006
  41. ncbi Particulate matter in the atmosphere: which particle properties are important for its effects on health?
    R M Harrison
    Division of Environmental Health and Risk Management, University of Birmingham, Edgbaston, UK
    Sci Total Environ 249:85-101. 2000
    ..The issue of particle size is currently unclear and more research is warranted...
  42. pmc Sulfated steroids as natural ligands of mouse pheromone-sensing neurons
    Francesco Nodari
    Department of Anatomy and Neurobiology, School of Medicine, Washington University in St Louis, St Louis, Missouri 63110, USA
    J Neurosci 28:6407-18. 2008
    ..These results provide an unprecedented characterization of the signals available for chemical communication among mice...
  43. ncbi Towards the phylogeny of APS reductases and sirohaem sulfite reductases in sulfate-reducing and sulfur-oxidizing prokaryotes
    W M Hipp
    Institut für Mikrobiologie and Biotechnologie, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    Microbiology 143:2891-902. 1997
    ..The aprA gene was demonstrated to be a suitable DNA probe for the identification of apr genes from organisms of different phylogenetic positions. PCR primers and conditions for the amplification of apr homologous regions are described...
  44. ncbi In vitro demonstration of anaerobic oxidation of methane coupled to sulphate reduction in sediment from a marine gas hydrate area
    Katja Nauhaus
    Max Planck Institut für Marine Mikrobiologie, D 28359 Bremen, Germany
    Environ Microbiol 4:296-305. 2002
    ..Hence, the experiments did not provide evidence for one of these compounds acting as a free extracellular intermediate (intercellular shuttle) during AOM by the presently investigated consortia...
  45. pmc The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism
    Kathryne S Auernik
    Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695 7905, USA
    Appl Environ Microbiol 74:682-92. 2008
    ..Many hypothetical proteins were also differentially transcribed, indicating that aspects of the iron and sulfur metabolism of M. sedula remain to be identified and characterized...
  46. pmc Multiple lateral transfers of dissimilatory sulfite reductase genes between major lineages of sulfate-reducing prokaryotes
    M Klein
    Lehrstuhl fur Mikrobiologie, Technische Universitat Munchen, D 85350 Freising, Germany
    J Bacteriol 183:6028-35. 2001
  47. ncbi Expression and activity of sulfate transporters and APS reductase in curly kale in response to sulfate deprivation and re-supply
    Aleksandra Koralewska
    Laboratory of Plant Physiology, University of Groningen, 9750 AA Haren, The Netherlands
    J Plant Physiol 166:168-79. 2009
  48. ncbi Chemical characteristic and anticoagulant activity of the sulfated polysaccharide isolated from Monostroma latissimum (Chlorophyta)
    Wenjun Mao
    Institute of Marine Drug and Food, Ocean University of China, 5 Yusan road, Qingdao 266003, China
    Int J Biol Macromol 44:70-4. 2009
    ..The anticoagulant property of the sulfated polysaccharide was mainly attributed to powerful potentiation thrombin by heparin cofactor II...
  49. ncbi Overview of anticoagulant activity of sulfated polysaccharides from seaweeds in relation to their structures, focusing on those of green seaweeds
    M Ciancia
    Catedra de Quimica de Biomoleculas, Departamento de Biologia Aplicada y Alimentos, Facultad de Agronomia, Universidad de Buenos Aires, Av San Martin 4453, 1417 Buenos Aires, Argentina
    Curr Med Chem 17:2503-29. 2010
    ..Other mechanisms are also proposed and these differences could be attributed to the diversity of structures of the polysaccharides evaluated and to the fact that one compound may have more than one target protease...
  50. ncbi In vitro cell growth of marine archaeal-bacterial consortia during anaerobic oxidation of methane with sulfate
    Katja Nauhaus
    Max Planck Institute for Marine Microbiology, Celsiusstrasse 1, D 28359 Bremen, Germany
    Environ Microbiol 9:187-96. 2007
  51. pmc Effects of temperature and pressure on sulfate reduction and anaerobic oxidation of methane in hydrothermal sediments of Guaymas Basin
    Jens Kallmeyer
    Max Planck Institute for Marine Microbiology, 28359 Bremen, Germany
    Appl Environ Microbiol 70:1231-3. 2004
    ..A maximum SR of several micromoles per cubic centimeter per day was found at between 60 and 95 degrees C and 2.2 x 10(7) and 4.5 x 10(7) Pa. Maximal AOM was observed at 35 to 90 degrees C but generally accounted for less than 5% of SR...
  52. ncbi Genes of primary sulfate assimilation are part of the glucosinolate biosynthetic network in Arabidopsis thaliana
    Ruslan Yatusevich
    Botanisches Institut der Universitat zu Koln, Otto Fischer Str 6, D 50674 Köln, Germany
    Plant J 62:1-11. 2010
    ..Altogether the data revealed that the MYB transcription factors regulate genes of primary sulfate metabolism and that the genes involved in the synthesis of activated sulfate are part of the glucosinolate biosynthesis network...
  53. ncbi Quantitative trait loci analysis of nitrate storage in Arabidopsis leading to an investigation of the contribution of the anion channel gene, AtCLC-c, to variation in nitrate levels
    Hisatomi Harada
    National Institute of Livestock and Grassland Science, 768, Senbonmatsu, NASU, Tochigi, 329 2793, Japan
    J Exp Bot 55:2005-14. 2004
    ..These and published results suggest that multiple genes affect nitrate concentrations in plants and that AtCLC-c and other members of the AtCLC gene family play some role in this...
  54. pmc Genome sequence of the deltaproteobacterial strain NaphS2 and analysis of differential gene expression during anaerobic growth on naphthalene
    Raymond J DiDonato
    Microbiology Department, University of Massachusetts, Amherst, Massachusetts, USA
    PLoS ONE 5:e14072. 2010
    ..To further characterize pathways involved in naphthalene degradation in NaphS2, the draft genome was sequenced, and gene and protein expression examined...
  55. pmc Overestimation of the abundance of sulfate-reducing bacteria in human feces by quantitative PCR targeting the Desulfovibrio 16S rRNA gene
    C T Christophersen
    CSIRO Food and Nutritional Sciences, Gate 13, Kintore Avenue, Adelaide 5000, South Australia, Australia
    Appl Environ Microbiol 77:3544-6. 2011
    ..We show that the 16S rRNA gene assay overestimated SRB abundance in feces from 24 adults compared to QPCR assays using primers targeting two genes involved in SRB energy metabolism...
  56. ncbi In vitro and in vivo immunomodulatory activity of sulfated polysaccharides from Enteromorpha prolifera
    Jin Kyung Kim
    Department of Biomedical Science, Catholic University of Daegu, Gyeongsan, Gyeongbuk, 712 702, Korea
    Int J Biol Macromol 49:1051-8. 2011
    ..These in vitro and in vivo results suggest that the sulfated polysaccharides are strong immunostimulators...
  57. pmc Contrasting patterns of niche partitioning between two anaerobic terminal oxidizers of organic matter
    Brian B Oakley
    University of Warwick, School of Life Sciences, Coventry, UK
    ISME J 6:905-14. 2012
    ..We concluded that niche partitioning can be an important force structuring microbial populations, with biotic and abiotic components having very different effects depending on the physiology and ecology of each taxon...
  58. ncbi The key enzyme of sulfate assimilation, adenosine 5'-phosphosulfate reductase, is regulated by HY5 in Arabidopsis
    Bok Rye Lee
    Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK
    Plant J 67:1042-54. 2011
    ..Altogether, these data show that HY5 plays an important role in regulation of APR gene expression and plant sulfate assimilation...
  59. pmc Sulphur limitation and early sulphur deficiency responses in poplar: significance of gene expression, metabolites, and plant hormones
    Anne Honsel
    Albert Ludwigs University Freiburg, Institute of Forest Botany and Tree Physiology, Freiburg, Germany
    J Exp Bot 63:1873-93. 2012
    ..Despite these consequences, the impact of S depletion on growth of poplar plants appears to be less severe than in Brassicaceae such as Arabidopsis thaliana or Brassica sp...
  60. pmc A tyrosine-sulfated CCR5-mimetic peptide promotes conformational transitions in the HIV-1 envelope glycoprotein
    Jo Ann Kwong
    Department of Pediatrics, Harvard Medical School, Children s Hospital, Boston, Massachusetts 02115, USA
    J Virol 85:7563-71. 2011
    ..DM1 has significant advantages over other inhibitors that target both coreceptor and CD4-binding sites, and it may serve as a lead for a new class of HIV-1 inhibitor peptides...
  61. ncbi Did sulfate availability facilitate the evolutionary expansion of chlorophyll a+c phytoplankton in the oceans?
    S Ratti
    Laboratorio di Fisiologia delle Alghe, Dipartimento di Scienze del Mare, Universita Politecnica delle Marche, Ancona, Italy
    Geobiology 9:301-12. 2011
  62. pmc Structure-activity relationships for hydroxylated polychlorinated biphenyls as inhibitors of the sulfation of dehydroepiandrosterone catalyzed by human hydroxysteroid sulfotransferase SULT2A1
    Edugie J Ekuase
    Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, United States
    Chem Res Toxicol 24:1720-8. 2011
  63. ncbi Physiological roles and regulation of mammalian sulfate transporters
    D Markovich
    Department of Physiology and Pharmacology, University of Queensland, Brisbane, Queensland, Australia
    Physiol Rev 81:1499-533. 2001
  64. pmc 6-Sulphated chondroitins have a positive influence on axonal regeneration
    Rachel Lin
    Department of Clinical Neurosciences, Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e21499. 2011
  65. ncbi Seasonal and cell type specific expression of sulfate transporters in the phloem of Populus reveals tree specific characteristics for SO(4)(2-) storage and mobilization
    Jasmin Dürr
    Chair of Tree Physiology, Institute of Forest Botany and Tree Physiology, Albert Ludwigs University Freiburg, Georges Köhler Allee 053 054, 79110 Freiburg, Germany
    Plant Mol Biol 72:499-517. 2010
    ..However, PtaSULTR1;1 abundance correlated negatively with sulfate content in leaves, supporting its function in phloem loading. Taken together, these findings indicate a transcriptional regulation of sulfate distribution in poplar trees...
  66. ncbi The sulfate transporter family in wheat: tissue-specific gene expression in relation to nutrition
    Peter Buchner
    Rothamsted Research, Plant Science Department, West Common, Harpenden, Hertfordshire, UK
    Mol Plant 3:374-89. 2010
  67. ncbi Iron corrosion by novel anaerobic microorganisms
    Hang T Dinh
    Max Planck Institute for Marine Microbiology, Celsiusstrasse 1, 28359 Bremen, Germany
    Nature 427:829-32. 2004
    ..Similarly, a newly isolated Methanobacterium-like archaeon produced methane with iron faster than do known hydrogen-using methanogens, again suggesting a more direct access to electrons from iron than via hydrogen consumption...
  68. pmc Microbial links between sulfate reduction and metal retention in uranium- and heavy metal-contaminated soil
    Jana Sitte
    Institute of Ecology, Friedrich Schiller University Jena, D 07743 Jena, Germany
    Appl Environ Microbiol 76:3143-52. 2010
    ..Our results suggest that (i) ongoing sulfate reduction in contaminated soil resulted in in situ metal attenuation and (ii) the fate of uranium mobility is not predictable and may lead to downstream contamination of adjacent ecosystems...
  69. pmc Disruption of adenosine-5'-phosphosulfate kinase in Arabidopsis reduces levels of sulfated secondary metabolites
    Sarah G Mugford
    Department of Metabolic Biology, John Ines Centre, Norwich, Norfolk NR4 7UH, United Kingdom
    Plant Cell 21:910-27. 2009
    ..The data indicate that the APK1 and APK2 isoforms of APS kinase play a major role in the synthesis of secondary sulfated metabolites and are required for normal growth rates...
  70. ncbi Desulfovibrio piezophilus sp. nov., a piezophilic, sulfate-reducing bacterium isolated from wood falls in the Mediterranean Sea
    Saber Khelaifia
    IRD, UMR 180, IFR BAIM, Universités de Provence et de la Méditerranée, ESIL case 925, 163 Avenue de Luminy, F 13288 Marseille Cedex 9, France
    Int J Syst Evol Microbiol 61:2706-11. 2011
  71. ncbi Deposition and cycling of sulfur controls mercury accumulation in Isle Royale fish
    Paul E Drevnick
    Department of Zoology, Miami University, Oxford, Ohio 45056, USA
    Environ Sci Technol 41:7266-72. 2007
    ..Therefore, reductions in anthropogenic sulfur emissions may provide a synergistic solution to the mercury problem in sulfate-limited freshwaters...
  72. pmc The 3'-phosphoadenosine 5'-phosphosulfate transporters, PAPST1 and 2, contribute to the maintenance and differentiation of mouse embryonic stem cells
    Norihiko Sasaki
    Laboratory of Cell Biology, Department of Bioinformatics, Faculty of Engineering, Soka University, Hachioji, Tokyo, Japan
    PLoS ONE 4:e8262. 2009
    ..We propose that PAPST-dependent sulfation of HS or CS chains, which is regulated developmentally, regulates the extrinsic signaling required for the maintenance and normal differentiation of mESCs...
  73. ncbi How sulphate-reducing microorganisms cope with stress: lessons from systems biology
    Jizhong Zhou
    Stephenson Research and Technology Center, 101 David L Boren Blvd, Institut for Environmental Genomics and Department of Botany and Microbiology, University of Oklahoma, Norman, Oklahoma 73019, USA
    Nat Rev Microbiol 9:452-66. 2011
  74. ncbi Structure and antiviral activity of sulfated fucans from Stoechospermum marginatum
    Utpal Adhikari
    Natural Products Laboratory, Department of Chemistry, The University of Burdwan, Golapbag, Burdwan, West Bengal 713 104, India
    Phytochemistry 67:2474-82. 2006
    ..No direct inactivating effect on virions was observed in a virucidal assay. The absence of anticoagulant activity at concentrations near EC50 confirmed that there was no correlation between the antiviral and anticoagulant properties...
  75. ncbi Regulation of sulphate assimilation by glutathione in poplars (Populus tremula x P. alba) of wild type and overexpressing gamma-glutamylcysteine synthetase in the cytosol
    Tanja Hartmann
    Albert Ludwigs University of Freiburg, Institute of Forest Botany and Tree Physiology, Georges Köhler Allee 053, D 79110 Freiburg, Germany
    J Exp Bot 55:837-45. 2004
    ..However, OAS measurements revealed that OAS cannot be the only signal responsible for the lack of feedback regulation of APR by GSH in the transgenic poplars...
  76. ncbi The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans
    Maria E R Duarte
    Departamento de Bioquimica e Biologia Molecular, Universidade Federal do Parana, P O Box 19046, CEP 81531 990, Curitiba, Parana, Brazil
    Carbohydr Res 339:335-47. 2004
    ..Rhodomelaceae, Ceramiales), is made up of A-units highly substituted with sulfate groups on C-2 (28-30%), sulfates on C-2 and 4,6-O-(1'-carboxyethylidene) groups (9-15%), and only the C-2 sulfate groups (5-8%) with small amounts ..
  77. ncbi Anticoagulant properties of a sulfated galactan preparation from a marine green alga, Codium cylindricum
    K Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, 719 1197, Okayama, Japan
    Int J Biol Macromol 28:395-9. 2001
    ..The anticoagulant did not potentiate antithrombin III (AT III) and heparin cofactor II (HC II), thus the anticoagulant mechanism would be different from that of other anticoagulants isolated so far from the genus Codium...
  78. pmc Molecular characterization of sulfate-reducing bacteria in the Guaymas Basin
    Ashita Dhillon
    Marine Biological Laboratory, The Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, NASA Astrobiology Institute, 7 MBL Street, Woods Hole, MA 02543, USA
    Appl Environ Microbiol 69:2765-72. 2003
    ..In addition, the dsrAB sequencing approach revealed a novel group of sulfate-reducing prokaryotes that could not be identified by 16S rRNA sequencing...
  79. ncbi Sulfated polysaccharides from the red seaweed Georgiella confluens
    Adriana A Kolender
    Departamento de Quimica Organica, CIHIDECAR CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellon 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina
    Carbohydr Res 337:57-68. 2002
  80. ncbi Old age and gender influence the pharmacokinetics of inhaled manganese sulfate and manganese phosphate in rats
    David C Dorman
    CIIT Centers for Health Research, Research Triangle Park, NC 27709 2137, USA
    Toxicol Appl Pharmacol 197:113-24. 2004
    ..Data from this study should prove useful in developing dosimetry models for manganese that consider age or gender as potential sensitivity factors...
  81. ncbi Anti-herpes simplex virus activity of sulfated galactans from the red seaweeds Gymnogongrus griffithsiae and Cryptonemia crenulata
    Laura B Talarico
    Laboratorio de Virologia, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon 2, 1428 Buenos Aires, Argentina
    Int J Biol Macromol 34:63-71. 2004
    ..Most importantly, a significant protection against a murine vaginal infection with HSV-2 was afforded by topical treatment with the sulfated galactans...
  82. ncbi Isolation and characterization of a sulfated polysaccharide from the brown alga Sargassum patens and determination of its anti-herpes activity
    Wen Zhu
    Department of Biology, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Biochem Cell Biol 81:25-33. 2003
    ..3, 5.5, and 4.1 microg/mL, respectively. The 50% cytotoxic concentration (CC50) of SP-2a on the growth of normal Vero cell line was more than 4000 microg/mL. Therefore SP-2a of S. patens may be a potent agent for treating HSV infections...
  83. ncbi A fucoidan fraction from Ascophyllum nodosum
    M F Marais
    , , BP 53, F-38041, Grenoble, France
    Carbohydr Res 336:155-9. 2001
    ..Such diversity in the structural features of this fucoidan may be of importance for its various biological properties...
  84. ncbi Structural characteristics and in vitro macrophage activation of acetyl fucoidan from Cladosiphon okamuranus
    Takeshi Teruya
    The United Graduate School of Agricultural Sciences, Kagoshima University, 1 21 24, Korimoto, Kagoshima 890 0065, Japan
    Glycoconj J 26:1019-28. 2009
    ..The results suggested that CAF induced macrophage activation through membrane receptors TLR4, CD14 and SRA, and MAPK signaling pathways...
  85. pmc A Sinorhizobium meliloti lipopolysaccharide mutant altered in cell surface sulfation
    David H Keating
    Howard Hughes Medical Institute Department of Biology, Stanford University, Stanford, California 94305, USA
    J Bacteriol 184:6681-9. 2002
    ..Finally, we determined that the lps-212 mutation resulted in a reduced ability to elicit the formation of plant nodules and by altered infection thread structures that aborted prematurely...
  86. pmc Heterofucans from the brown seaweed Canistrocarpus cervicornis with anticoagulant and antioxidant activities
    Rafael Barros Gomes Camara
    Laboratory of Biotechnology of Natural Polymers, Department of Biochemistry, Federal University of Rio Grande do Norte, Natal RN, Brazil
    Mar Drugs 9:124-38. 2011
    ..cervicornis polysaccharides as anticoagulants and antioxidants. Further purification steps and additional studies on structural features as well as in vivo experiments are needed to test the viability of their use as therapeutic agents...
  87. ncbi Structural and functional insights into sulfated galactans: a systematic review
    Vitor H Pomin
    Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA
    Glycoconj J 27:1-12. 2010
    ..This review will present an overview about the principle structural and functional information of SGs. Other important aspects concerning occurrence, biology, phylogeny, and future directions, will also be reported...
  88. pmc Regulation of sulfate assimilation by nitrogen in Arabidopsis
    A Koprivova
    Institute of Plant Physiology, Altenbergrain 21, CH 3013 Bern, Switzerland
    Plant Physiol 122:737-46. 2000
    ..Our data demonstrate that sulfate reduction is regulated by nitrogen nutrition at the transcriptional level and that OAS plays a major role in this regulation...
  89. pmc Crystal structure of ATP sulfurylase from Saccharomyces cerevisiae, a key enzyme in sulfate activation
    T C Ullrich
    Max Planck Institut fur Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    EMBO J 20:316-29. 2001
    ..Despite having similar folds and active site design, examination of the active site of ATPS and comparison with known structures of related nucleotidylyl transferases reveal a novel ATP binding mode that is peculiar to ATP sulfurylases...
  90. ncbi Anaerobic degradation of naphthalene by a pure culture of a novel type of marine sulphate-reducing bacterium
    A Galushko
    Fakultat fur Biologie, Universitat Konstanz, Germany
    Environ Microbiol 1:415-20. 1999
    ..Quantification of substrate consumption, sulphide formation and formed cell mass revealed that naphthalene was completely oxidized with sulphate as the electron acceptor...
  91. pmc Proteins induced by sulfate limitation in Escherichia coli, Pseudomonas putida, or Staphylococcus aureus
    M A Kertesz
    Institute of Microbiology, Swiss Federal Institute of Technology, ETH Zentrum, Zurich
    J Bacteriol 175:1187-90. 1993
    ..aureus was seen to increase by up to 140-fold, suggesting that the proteins induced under these conditions may be involved in sulfur metabolism. We propose that these proteins are members of a sulfate starvation-induced stimulon...
  92. ncbi Chapter 7. Tyrosine sulfation of HIV-1 coreceptors and other chemokine receptors
    Hyeryun Choe
    Department of Pediatrics, Harvard Medical School, Perlmutter Laboratory, Children s Hospital, Boston, Massachusetts, USA
    Methods Enzymol 461:147-70. 2009
    ..Here we describe the use of these various approaches to study the role of tyrosine sulfation of chemokine receptors in ligand binding and HIV-1 entry...
  93. ncbi The sulfate activation locus of Escherichia coli K12: cloning, genetic, and enzymatic characterization
    T S Leyh
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
    J Biol Chem 263:2409-16. 1988
    ..The genes are adjacent and are transcribed counterclockwise on the E. coli chromosome in the order cysDNC. cysN and cysC are within the same operon and cysDNC are not in an operon containing cysHIJ...
  94. ncbi Morin sulfates/glucuronides exert anti-inflammatory activity on activated macrophages and decreased the incidence of septic shock
    Shih Hua Fang
    Department of Microbiology, School of Medicine, China Medical University, Taichung 404, Taiwan
    Life Sci 74:743-56. 2003
    ..In this study, the effects of morin and its sulfates/glucuronides on the production of nitric oxide (NO) and cytokines from lipopolysaccharide (LPS)-activated ..
  95. ncbi Heparin/heparan sulfate biosynthesis: processive formation of N-sulfated domains
    Pernilla Carlsson
    Department of Medical Biochemistry and Microbiology at Uppsala University, Uppsala, Sweden
    J Biol Chem 283:20008-14. 2008
    ..We speculate that similar mechanisms may apply also to the regulation of HS biosynthesis in the living cell...
  96. ncbi Kinetics of heat-assisted persulfate oxidation of methyl tert-butyl ether (MTBE)
    Kun Chang Huang
    Environmental Research Institute, University of Connecticut, Storrs 06269, USA
    Chemosphere 49:413-20. 2002
    ..Additionally, MTBE degradation by persulfate in a groundwater was much slower than in phosphate-buffer solutions, most likely due to the presence of bicarbonate ions (radical scavengers) in the groundwater...
  97. ncbi Mechanism of mild acid hydrolysis of galactan polysaccharides with highly ordered disaccharide repeats leading to a complete series of exclusively odd-numbered oligosaccharides
    Bo Yang
    Glycoscience and Glycoengineering Laboratory, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China
    FEBS J 276:2125-37. 2009
    ..It is highly unusual to obtain exclusively odd-numbered oligosaccharides from polysaccharides composed of ordered disaccharide repeats...
  98. pmc Sulfate assimilation in eukaryotes: fusions, relocations and lateral transfers
    Nicola J Patron
    School of Botany, University of Melbourne, Victoria 3010, Australia
    BMC Evol Biol 8:39. 2008
  99. ncbi Biology and function of the reversible sulfation pathway catalysed by human sulfotransferases and sulfatases
    M W Coughtrie
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, UK
    Chem Biol Interact 109:3-27. 1998
    ..The genetic and environmental factors which are known to influence the activity and expression of human SULTs and sulfatases are also reviewed...
  100. ncbi Unequal functional redundancy between the two Arabidopsis thaliana high-affinity sulphate transporters SULTR1;1 and SULTR1;2
    Marie Barberon
    Centre International d Etudes Supérieures en Sciences Agronomiques, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Universite Montpellier II, Montpellier, France
    New Phytol 180:608-19. 2008
    ..The SULTR1;1 and SULTR1;2 genes display unequal functional redundancy, which leaves open for SULTR1;1 the possibility of displaying an additional function besides its role in sulphate membrane transport...
  101. ncbi Proteoglycan sulfation in cartilage and cell cultures from patients with sulfate transporter chondrodysplasias: relationship to clinical severity and indications on the role of intracellular sulfate production
    A Rossi
    Department of Biochemistry Alessandro Castellani, University of Pavia, Italy
    Matrix Biol 17:361-9. 1998

Research Grants62

  1. Synthetic Oligosaccharides for Probing Infection and Innate Immunity
    Geert Jan Boons; Fiscal Year: 2013
    ..synthesis of libraries of lipopolysaccharides (LPS), glycosylphosphatidylinositol (GPI) anchors and chondroitin sulfates (CS), and employ the resulting compounds to examine in detail the molecular aspects of several infectious and ..
  2. Expression of Heparan Sulfate 6-O-Endosulfatases in Idiopathic Pulmonary Fibrosis
    Xinping Yue; Fiscal Year: 2010
    ..HS) 6-O-endosulfatase 1 and 2 (Sulf1 and Sulf2), which are novel cell surface sulfatases that remove the 6-O-sulfates from specific HS intra-chain sites...
  3. Air pollution exposure and COPD in the Framingham Heart Study
    Mary B Rice; Fiscal Year: 2013 short-term exposure to air pollutants (fine particulate matter, black carbon, ozone, nitrogen oxides, sulfates and metals) will impair lung function by spirometry and DLCO after adjustment for smoking...
    Gregory J del Zoppo; Fiscal Year: 2010
    ..preliminary data, we propose that enzymes which degrade matrix heparan sulfate proteoglycans (HSPGs) and heparan sulfates (HSs) are generated following MCA:O, simultaneously with the matrix metalloproteinase pro-MMP-2, and are ..
  5. Trapping HIV in mucus with IgG antibodies
    SAMUEL LAI; Fiscal Year: 2012
    ..from reaching and binding to heparan-sulfate coated surface to mimic the initial adhesive steps of HIV to heparan sulfates of syndecans on target cells...
  6. Identification of Flavonoid Metabolites
    Jennifer S Brodbelt; Fiscal Year: 2010
    ..We will use commercially available enzymes to produce glucuronides and sulfates from parent flavonoid aglycones...
  7. Sulfatase Activated Fluorescent Probes for In Vivo Diagnostic Imaging of Cancer
    ..Although it is known that sulfatases can hydrolyze diverse aryl sulfates, slight modifications to the dye scaffolds (e.g...
  8. An Artificial Golgi: Controlled GAG Synthesis and Screening
    ROBERT J contact LINHARDT; Fiscal Year: 2010
    ..The proposed effort impacts human health by developing an artificial Golgi to synthesize a library of heparan sulfates and heparan sulfate oligosaccharides...
  9. Mechanisms and Functions of Human Sulfotransferases
    Guangping Chen; Fiscal Year: 2009
    ..The inhibition and activation effect of clinically important drug sulfates on catalytic activities of human SULTs will be investigated. E...
  10. Regulation of SULT1A1 in Human Breast
    SUSAN A KADLUBAR; Fiscal Year: 2012
    ..Because SULT1A1 sulfates the active metabolites of TAM and sulfation is generally considered to be a detoxification/elimination pathway, ..
  11. Mechanisms of Air Pollution Health Effects in Subjects with Heart Failure
    Gregory A Wellenius; Fiscal Year: 2011
    ..5), black carbon (BC, a measure of traffic-related pollution), sulfates (a measure of regional pollution), gaseous pollutants (CO, N02, S02, ozone), and meteorologic data...
  12. Nuclear Receptor Regulation of Bile Acid Sulfation
    ANDREW JOSEPH LICKTEIG; Fiscal Year: 2012
    ..1 and 2 is expected to confirm (1) that induction of Sults in mouse liver results in enhanced formation of BA sulfates, and (2) which Sults are responsible for BA-sulfation...
  13. Function of the MRP Family
    James M Gallo; Fiscal Year: 2013
    ..PMEA, restricts penetration of this agent into brain, and like Mrp3, functions in the basolateral extrusion of sulfates from hepatocytes...
  14. Function of the MRP Family
    Gary D Kruh; Fiscal Year: 2010
    ..PMEA, restricts penetration of this agent into brain, and like Mrp3, functions in the basolateral extrusion of sulfates from hepatocytes...
  15. Post-biosynthetic remodeling of heparan sulfate
    Joseph Zaia; Fiscal Year: 2013
    ..This research will explore the structure-function relationships of vascular heparan sulfates in order to inform efforts to develop protein binding microarrays, drugs and therapeutics.
    Dieter Bromme; Fiscal Year: 2007
    ..Chondroitin- and keratan sulfates enhance the collagenolytic activity of the protease, while dermatan and heparan sulfates are potent inhibitors...
    Arnold Caplan; Fiscal Year: 1999
    ..and structural information gained from the first experimental program to study subtle changes in chondroitin sulfates of chick aggrecan obtained from chick limb bud chondrocytes cultured and extracted at different developmental ..
  18. Novel Approaches to Structure/Function Analyses of Heparan Sulfate in vivo
    HANNES ERICH BUELOW; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Heparan sulfates (HS) are abundant and molecularly complex sugars of the extracellular space...
    ROGER LAINE; Fiscal Year: 1993
    ..Observations dating from 1988 showed that L- selectin (GP90mel) bound to polymeric fucose-sulfates (fucoidin), polyphosphomannans, and inhibited binding of lymphocytes to high endothelial venules...
    Mortimer Levitz; Fiscal Year: 1993
    ..The steroids to be assayed are the sulfates of 16 alpha hydroxydehydroepiandrosterone, androst-5-ene-3 beta, 16 alpha, 17 beta-triol, 16 alpha--..
  21. Correction of neural abnormalities in Hurler syndrome
    Pankaj Gupta; Fiscal Year: 2003
    ..They will compare the structure and binding properties of heparan sulfates from Hurler and normal MSC, identify the mechanism(s) by which abnormal glycosaminoglycas in Hurler cells lead to ..
  22. Stereoselective Atom Transfer
    KARL BARRY SHARPLESS; Fiscal Year: 2010
    ..Chief among these are epoxides, aziridines, cyclic sulfates, and episulfonium ions. New methods for the synthesis and manipulation of these intermediates are discussed...
  23. Antithrombotic Activity of Ascidian Glycosaminoglycans
    DOUGLAS TOLLEFSEN; Fiscal Year: 2004
    ..Dermatan sulfate is a related polymer that specifically activates HCII. Dermatan sulfates and heparin isolated from the marine invertebrates Styela plicata and Ascidia nigra differ from mammalian ..
    Aimin Wang; Fiscal Year: 2002
    DESCRIPTION (adapted from the application) Heparan sulfates (HSs) and heparin, proposed as endogenous defending molecules in the "glomerular self-defense", are inhibitors of mesangial cell growth in human proliferative nephritides, in ..
    ALLEN HORWITZ; Fiscal Year: 1992
    Mammalian sulfatases are a diverse group of enzymes which hydrolize steroid, mucopolysaccharide and glycolipid sulfates. The sulfatase deficiency disorders include a number of lysosomal storage diseases, and are a significant cause of ..
    J Marsh; Fiscal Year: 2001
    ..Following this, we have also found that mutations in the Drosophila syndecan gene, a major source of heparan sulfates in vertebrates, interact genetically with mutations of dishevelled, a key component of the wingless signaling ..
    BURTON TROPP; Fiscal Year: 1980
    ..These will include phosphonates, sulfates, and sulfonates, as well as phosphate species of special interest...
    ELVIN KABAT; Fiscal Year: 1992
    ..its VH and VL amino acid sequence as well the sequences of human monoclonal IgMs specific for chondroitin sulfates and Klebsiella K antigens, the group B antimeningococcal antibodies and those associated with motor neuron disease...
    ISIDORE DANISHEFSKY; Fiscal Year: 1991
    ..Detailed investigations will be performed on specific fractions on heparins and heparan sulfates from different animal and tissue sources with the purpose of defining the location of certain units or sequences ..
    Christopher Ross; Fiscal Year: 1991
    ..Heparan sulfates may serve to protect bFGF from proteolytic degradation, maintain it in insoluble form until released to exert its ..
    THEODORE WIDLANSKI; Fiscal Year: 1993
    ..Our goal is the synthesis and biological testing of sulfonate analogues of steroid sulfates to be used as antitumor agents. Sulfated carbohydrates are also play very important biological roles...
    M Thaler; Fiscal Year: 1980
    ..partial protection from the hepatotoxic effects of lithocholic acid by forming non-toxic, polar lithocholate sulfates. Our studies have shown that bile acid sulfotransferase is inducible in fetal liver by exposure to maternal ..
  33. Genetic Variation in Estrogen Sulfation Genes and Endometrial Cancer Risk
    VERONICA SETIAWAN; Fiscal Year: 2009
    ..Estrogen sulfotransferases catalyze the conversion of biologically active estrogens to inactive estrogen sulfates, thereby "diverting" these hormones from both receptor mediated and genotoxic pathways leading to carcinogenesis...
    David Pritchard; Fiscal Year: 1999
    ..The second specific aim is to determine the specificity of GBS hyaluronate lyase for chondroitin sulfates. Preliminary experiments revealed that GBS hyaluronate lyase cleavage of chondroitin sulfate occurs only at (31-4 ..
  35. Non-anticoagulant ODS Heparin in Myocardial Infarction
    ALAN CARDIN; Fiscal Year: 2002
    ..reductive alkalinization during lyophilization that selectively and quantitatively removes the 2-O and 3- O sulfates necessary for binding antithrombin III, critical for heparin's anti-coagulant effect...
  36. Neurosteroids and Smith-Lemli-Optiz Syndrome
    Cedric Shackleton; Fiscal Year: 2005
    ..These form two groups, steroid sulfates and allopregnanolone, which have opposing interactions with the MRs, and it has been suggested that their balance ..
  37. Pharmacogenetics of Sulfate Conjugation
    VIRGIL JORDAN; Fiscal Year: 2006
    ..SULTI El is a distinct SULT isoform that also sulfates estrogens...
    K Sharpless; Fiscal Year: 1999
    ..The main thrust relies on conversion of the diols into epoxide-like synthons, such as 1,2-cyclic sulfates. This work has a "synthetic methods" orientation but also includes planned syntheses of various biologically ..
    John Baker; Fiscal Year: 1992
    ..Keratan sulfates are constituents of cartilage and bone. they are heterogenous and polydisperse...
    Shantu Amin; Fiscal Year: 2000
    ..parent hydrocarbons, conjugated derivatives (chemical or biosynthetic such as glutathiones, glucuronides, and sulfates), and labeled (3H, 13C, 4C) analogs...
    Mary K Howett; Fiscal Year: 2003
    ..c.) Establishment of formulated alkyl sulfates as topical microbicides that can be applied to the vagina and provide protection from HPVs in addition to the ..
  42. Correction of Hurler syndrome by multipotent stem cells
    Pankaj Gupta; Fiscal Year: 2007
    ..During an R03 grant, we found that 1) structurally abnormal heparan sulfates (HS) in Hurler MAPC have defective binding interactions with FGF-2, thus impairing its biological activity on ..
    Thomas Haines; Fiscal Year: 1980
    ..The work is designed to explore the conformations of the lipids and a hypothetical structure of the bilayer which bases its stability on protonated sulfates. NMR, X-ray, and other physical methods are being utilized for these studies.
  44. The structural basis for APP cleavability
    Ya Ha; Fiscal Year: 2009
    ..Since heparin binding to APP reversed the effect of the mutation, it was hypothesized that intracellular heparan sulfates, by forming complexes with APP inside the cell, could function to inhibit the proteolytic reaction...
  45. A Thermo Electron LTQ Mass Spectrometer
    Joseph Zaia; Fiscal Year: 2006
    ..2) the role of N-linked glycosylation in submandibular gland development (Kukuruzinska); (3) the role of heparan sulfates in vascular smooth muscle cell proliferation (Nugent); (4) the primary and post-trranslational modification ..
  46. Glycosaminoglycan-Protein Binding
    Joseph Zaia; Fiscal Year: 2006
    ..abstract_text> ..
  47. The Glycocalyx and Endothelial Barrier Regulation
    RANDAL DULL; Fiscal Year: 2005
    ..This K08 will provide the foundation for a research career dedicated to understanding the molecular mechanisms of endothelial barrier regulation. ..
  48. Novel Risk Factors for Kidney Stone Formation
    Eric Taylor; Fiscal Year: 2008
    ..At the completion of this career development award, Dr. Taylor will have a unique combination of skills and experience that will enable him to succeed as an independent clinical investigator. ..
    Thomas Walle; Fiscal Year: 2005
    ..The findings from the proposed studies should help us understand the bioavailability of the flavonoids, facilitating optimization of the chemopreventive utility of these natural or synthetic compounds. ..
    Martin Ronis; Fiscal Year: 2006
    ..The role of CYP2E1 and free radicals in the skeletal toxicity of ethanol during these periods will also be studied. ..
  51. K12 Expression: Cornea-Type Epithelial Differentiation
    WINSTON KAO; Fiscal Year: 2008
    ..Aim 3 is to examine roles of Fos on corneal-type epithelium differentiation and corneal wound healing as described in Aim 2. ..
  52. Novel Genes Involved in Drug Response
    Ruthann Nichols; Fiscal Year: 2002
    ..Ultimately, our research will determine the role of these gene products in mediating the effect of nicotine in humans. ..
    Rahul Kuver; Fiscal Year: 2003
    ..3. Compare and contrast the mechanisms of activation of ABCA1 via the cAMP responsive and the LXRalpha/RXR- responsive pathways. ..
  54. Mice Overexpressing rtTA and Cre in Corneal Epithelium
    WINSTON KAO; Fiscal Year: 2004
    ..These mouse lines will be useful in preparing mouse lines for studies of altered genetic functions from the corneal epithelium-specific gene ablation and overexpression of reporter genes. ..
  55. Development of Hydrogel Spinal Disc Replacement
    Barbara Boyan; Fiscal Year: 2004
    ..abstract_text> ..
    Edward Harris; Fiscal Year: 2005
    ..This type 1 receptor is the only known HA receptor to bind and internalize HA and Chondroitin Sulfates (CS) though clathrin-mediated endocytosis...
  57. Structural and biophysical analysis of a viral IRES
    JEFFREY KIEFT; Fiscal Year: 2009
    ..Finally, we will solve the crystal structure of the complete IRES RNA, to include the domain critical for binding the 40S subunit as well as the domain proposed to occupy the P-site on the ribosome. ..
  58. Gonadal vs. Genomic Influences on Xenobiotic Metabolism
    LAURA VAN WINKLE; Fiscal Year: 2008
    ..The proposed studies are relevant to diseases associated with pulmonary remodeling and PAH activation, such as lung cancer. ..
  59. Allosteric Coupling in Homomeric Cys-loop Receptors
    STEVEN SINE; Fiscal Year: 2009
    ..Knowledge of how Cys-loop receptors operate at the molecular level is essential to developing therapeutic strategies and drugs with fewer side effects. ..