sulfates

Summary

Summary: Inorganic salts of sulfuric acid.

Top Publications

  1. ncbi Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica
    Jing Wang
    Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China
    Int J Biol Macromol 42:127-32. 2008
  2. doi Interplay of SLIM1 and miR395 in the regulation of sulfate assimilation in Arabidopsis
    Cintia G Kawashima
    School of Biological Sciences, University of East Anglia, Norwich, UK
    Plant J 66:863-76. 2011
  3. doi The ecology and biotechnology of sulphate-reducing bacteria
    Gerard Muyzer
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Nat Rev Microbiol 6:441-54. 2008
  4. ncbi A marine microbial consortium apparently mediating anaerobic oxidation of methane
    A Boetius
    Max Planck Institute for Marine Microbiology, Bremen, Germany
    Nature 407:623-6. 2000
  5. doi Control of sulfur partitioning between primary and secondary metabolism
    Sarah G Mugford
    Department of Metabolic Biology, John Innes Centre, Norwich NR4 7UH, UK
    Plant J 65:96-105. 2011
  6. doi A preponderantly 4-sulfated, 3-linked galactan from the green alga Codium isthmocladum
    Eduardo H C Farias
    Laboratório de Biotecnologia de Polímeros Naturais, Departamento de Bioquimica, Universidade Federal do Rio Grande do Norte, Natal, RN, 59072 970, Brazil
    Glycobiology 18:250-9. 2008
  7. doi MicroRNA395 mediates regulation of sulfate accumulation and allocation in Arabidopsis thaliana
    Gang Liang
    Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming, Yunnan 650223, China
    Plant J 62:1046-57. 2010
  8. doi Focus on antivirally active sulfated polysaccharides: from structure-activity analysis to clinical evaluation
    Tuhin Ghosh
    Department of Chemistry, Natural Products Laboratory, University of Burdwan, WB 713 104, India
    Glycobiology 19:2-15. 2009
  9. pmc Nutritional homeostasis in batch and steady-state culture of yeast
    Alok J Saldanha
    Department of Genetics, Stanford University Medical School, Stanford, CA 94305, USA
    Mol Biol Cell 15:4089-104. 2004
  10. pmc Comparative analysis of methane-oxidizing archaea and sulfate-reducing bacteria in anoxic marine sediments
    V J Orphan
    Monterey Bay Aquarium Research Institute, 7700 Sandholdt Rd, P O Box 628, Moss Landing, California 95039
    Appl Environ Microbiol 67:1922-34. 2001

Research Grants

  1. SYNTHESIS OF GLYCOSAMINOGLYCAN OLIGOSACCHARIDES
    Robert Linhardt; Fiscal Year: 2004
  2. Chemoenzymatic Synthesis of Glycosaminoglycan Oligos
    Robert Linhardt; Fiscal Year: 2009
  3. Chemoenzymatic Synthesis of Glycosaminoglycan Oligos
    Robert Linhardt; Fiscal Year: 2007
  4. MUCOPOLYSACCHARIDOSES AND CATHEPSIN K
    Dieter Bromme; Fiscal Year: 2007
  5. Correction of neural abnormalities in Hurler syndrome
    Pankaj Gupta; Fiscal Year: 2003
  6. STRUCTURE OF ANTIMITOGENIC MESANGIAL HEPARAN SULFATES
    Aimin Wang; Fiscal Year: 2002
  7. IN VIVO ROLE OF PROTEOGLYCANS IN GROWTH FACTOR SIGNALING
    J Marsh; Fiscal Year: 2001
  8. CARCINOGENESIS: HIGHLY REACTIVE NITROSAMINES
    RICHARD LOEPPKY; Fiscal Year: 1993
  9. Stereoselective Atom Transfer
    KARL BARRY SHARPLESS; Fiscal Year: 2010
  10. MATRIX METALLOPROTEINASES AND NEURONS IN FOCAL ISCHEMIA
    Gregory Del Zoppo; Fiscal Year: 2007

Detail Information

Publications322 found, 100 shown here

  1. ncbi Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica
    Jing Wang
    Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China
    Int J Biol Macromol 42:127-32. 2008
    ..Available data obtained with in vitro models suggested that the ratio of sulfate content/fucose was an effective indicator to antioxidant activity of the samples...
  2. doi Interplay of SLIM1 and miR395 in the regulation of sulfate assimilation in Arabidopsis
    Cintia G Kawashima
    School of Biological Sciences, University of East Anglia, Norwich, UK
    Plant J 66:863-76. 2011
    ..Thus, miR395 is an integral part of the regulatory circuit controlling plant sulfate assimilation with a complex mechanism of action...
  3. doi The ecology and biotechnology of sulphate-reducing bacteria
    Gerard Muyzer
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Nat Rev Microbiol 6:441-54. 2008
    ..Although SRB have been studied for more than a century, it is only with the recent emergence of new molecular biological and genomic techniques that we have begun to obtain detailed information on their way of life...
  4. ncbi A marine microbial consortium apparently mediating anaerobic oxidation of methane
    A Boetius
    Max Planck Institute for Marine Microbiology, Bremen, Germany
    Nature 407:623-6. 2000
    ..These aggregates were abundant in gas-hydrate-rich sediments with extremely high rates of methane-based sulphate reduction, and apparently mediate anaerobic oxidation of methane...
  5. doi Control of sulfur partitioning between primary and secondary metabolism
    Sarah G Mugford
    Department of Metabolic Biology, John Innes Centre, Norwich NR4 7UH, UK
    Plant J 65:96-105. 2011
    ..Thus, at least in Arabidopsis, the interplay between APS reductase and APS kinase is important for sulfur partitioning between the primary and secondary metabolism...
  6. doi A preponderantly 4-sulfated, 3-linked galactan from the green alga Codium isthmocladum
    Eduardo H C Farias
    Laboratório de Biotecnologia de Polímeros Naturais, Departamento de Bioquimica, Universidade Federal do Rio Grande do Norte, Natal, RN, 59072 970, Brazil
    Glycobiology 18:250-9. 2008
    ..A comparison of sulfated galactans from different marine taxonomic groups revealed similar backbones of 3-beta-D-Galp-1...
  7. doi MicroRNA395 mediates regulation of sulfate accumulation and allocation in Arabidopsis thaliana
    Gang Liang
    Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming, Yunnan 650223, China
    Plant J 62:1046-57. 2010
    ..Our research showed that miR395 is involved in the regulation of sulfate accumulation and allocation by targeting APS genes and SULTR2;1, respectively...
  8. doi Focus on antivirally active sulfated polysaccharides: from structure-activity analysis to clinical evaluation
    Tuhin Ghosh
    Department of Chemistry, Natural Products Laboratory, University of Burdwan, WB 713 104, India
    Glycobiology 19:2-15. 2009
    ..This review summarizes experimental evidence indicating that sulfated polysaccharides might become increasingly important in drug development for the prevention of sexually transmitted diseases in the near future...
  9. pmc Nutritional homeostasis in batch and steady-state culture of yeast
    Alok J Saldanha
    Department of Genetics, Stanford University Medical School, Stanford, CA 94305, USA
    Mol Biol Cell 15:4089-104. 2004
    ....
  10. pmc Comparative analysis of methane-oxidizing archaea and sulfate-reducing bacteria in anoxic marine sediments
    V J Orphan
    Monterey Bay Aquarium Research Institute, 7700 Sandholdt Rd, P O Box 628, Moss Landing, California 95039
    Appl Environ Microbiol 67:1922-34. 2001
    ....
  11. ncbi Structure of a fucoidan from the brown seaweed Fucus evanescens C.Ag
    Maria I Bilan
    N D Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninskii prosp 47, 119991 Moscow, Russian Federation
    Carbohydr Res 337:719-30. 2002
    ..Additional sulfate occupies position 4 in a part of 3-linked fucose residues, whereas a part of the remaining hydroxyl groups is randomly acetylated...
  12. pmc Sulphur flux through the sulphate assimilation pathway is differently controlled by adenosine 5'-phosphosulphate reductase under stress and in transgenic poplar plants overexpressing gamma-ECS, SO, or APR
    Ursula Scheerer
    Albert Ludwigs University Freiburg, Institute of Forest Botany and Tree Physiology, Chair of Tree Physiology, Georges Köhler Allee 053 054, Freiburg, Germany
    J Exp Bot 61:609-22. 2010
    ..A possible loss of control under certain conditions, that is Cd treatment, Acetochlor treatment, and in APR overexpressing poplar, is discussed...
  13. ncbi Sulfated seaweed polysaccharides as antiviral agents
    Elsa B Damonte
    Virologia, Departamento de Quimica Biologica, CIHIDECAR CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellon 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina
    Curr Med Chem 11:2399-419. 2004
    ....
  14. ncbi Methane as fuel for anaerobic microorganisms
    Rudolf K Thauer
    Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Strasse, D 35043 Marburg, Germany
    Ann N Y Acad Sci 1125:158-70. 2008
    ..The first step in methane oxidation is most likely the exergonic formation of 2-methylsuccinate from fumarate and methane catalyzed by a glycine-radical enzyme...
  15. doi Genes of primary sulfate assimilation are part of the glucosinolate biosynthetic network in Arabidopsis thaliana
    Ruslan Yatusevich
    Botanisches Institut der Universitat zu Koln, Otto Fischer Str 6, D 50674 Köln, Germany
    Plant J 62:1-11. 2010
    ..Altogether the data revealed that the MYB transcription factors regulate genes of primary sulfate metabolism and that the genes involved in the synthesis of activated sulfate are part of the glucosinolate biosynthesis network...
  16. doi A cultured greigite-producing magnetotactic bacterium in a novel group of sulfate-reducing bacteria
    Christopher T Lefèvre
    Laboratoire de Bioenergetique Cellulaire, UMR 6191, Commissariat à l Energie Atomique Cadarache, Direction des Sciences du Vivant, Institut de Biologie Environnementale et Biotechnologie, Saint Paul lez Durance, France
    Science 334:1720-3. 2011
    ..Genomic analysis of BW-1 reveals the presence of two different magnetosome gene clusters, suggesting that one may be responsible for greigite biomineralization and the other for magnetite...
  17. ncbi Desulfohalobium utahense sp. nov., a moderately halophilic, sulfate-reducing bacterium isolated from Great Salt Lake
    Trine Fredlund Jakobsen
    Department of Microbiology, University of Aarhus, Ny Munkegade Building 1540, DK 8000 Aarhus C, Denmark
    Int J Syst Evol Microbiol 56:2063-9. 2006
    ..On the basis of phenotypic and genotypic characteristics, the novel species Desulfohalobium utahense sp. nov. is proposed, with strain EtOH3(T) (=VKM B-2384(T)=DSM 17720(T)) as the type strain...
  18. ncbi Desulfonauticus submarinus gen. nov., sp. nov., a novel sulfate-reducing bacterium isolated from a deep-sea hydrothermal vent
    Carine Audiffrin
    IRD, UR 101 Extrêmophiles, IFR BAIM, Universités de Provence et de la Méditerranée, ESIL, Case 925, 163 avenue de la Méditerranée, 13288 Marseille Cedex 09, France
    Int J Syst Evol Microbiol 53:1585-90. 2003
    ..nov., sp. nov...
  19. doi Chapter 7. Tyrosine sulfation of HIV-1 coreceptors and other chemokine receptors
    Hyeryun Choe
    Department of Pediatrics, Harvard Medical School, Perlmutter Laboratory, Children s Hospital, Boston, Massachusetts, USA
    Methods Enzymol 461:147-70. 2009
    ..Here we describe the use of these various approaches to study the role of tyrosine sulfation of chemokine receptors in ligand binding and HIV-1 entry...
  20. ncbi Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp
    Hyi Seung Lee
    Marine Natural Products Laboratory, Korea Ocean Research and Development Institute, Ansan PO Box 29, Seoul 425 600, Republic of Korea
    Bioorg Med Chem Lett 17:2483-6. 2007
    Two sesterterpene sulfates (1-2) were isolated from tropical sponge Hippospongia sp. and their inhibitory activities against isocitrate lyase (ICL) from the rice blast fungus Mgnaporthe grisea were evaluated...
  21. doi The key enzyme of sulfate assimilation, adenosine 5'-phosphosulfate reductase, is regulated by HY5 in Arabidopsis
    Bok Rye Lee
    Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK
    Plant J 67:1042-54. 2011
    ..Altogether, these data show that HY5 plays an important role in regulation of APR gene expression and plant sulfate assimilation...
  22. doi Evaluating the possible genotoxic, mutagenic and tumor cell proliferation-inhibition effects of a non-anticoagulant, but antithrombotic algal heterofucan
    Jailma Almeida-Lima
    Departamento de Bioquimica, Universidade Federal do Rio Grande do Norte, Av Senador Salgado Filho, Lagoa Nova, CEP 59072 970, Natal, Brazil
    J Appl Toxicol 30:708-15. 2010
    ..In conclusion, this study indicates that the S. schröederi fucan A was not found to be genotoxic or mutagenic compound; thus it could be used in new antithrombotic drug development...
  23. pmc Chondroitin-4-sulfation negatively regulates axonal guidance and growth
    Hang Wang
    Developmental Neurobiology Section, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 121:3083-91. 2008
    ..Thus, our findings show that specific sulfation along the carbohydrate backbone carries instructions to regulate neuronal function...
  24. pmc Effects of temperature and pressure on sulfate reduction and anaerobic oxidation of methane in hydrothermal sediments of Guaymas Basin
    Jens Kallmeyer
    Max Planck Institute for Marine Microbiology, 28359 Bremen, Germany
    Appl Environ Microbiol 70:1231-3. 2004
    ..A maximum SR of several micromoles per cubic centimeter per day was found at between 60 and 95 degrees C and 2.2 x 10(7) and 4.5 x 10(7) Pa. Maximal AOM was observed at 35 to 90 degrees C but generally accounted for less than 5% of SR...
  25. ncbi The three desulfoglucosinolate sulfotransferase proteins in Arabidopsis have different substrate specificities and are differentially expressed
    Marion Klein
    Institute for Botany, University of Hannover, Germany
    FEBS J 273:122-36. 2006
    ..High (500 microM) and low (50 microM) sulfate concentrations in the medium did not influence the levels of expression...
  26. doi Plant sulfate assimilation genes: redundancy versus specialization
    Stanislav Kopriva
    John Innes Centre, Norwich, NR4 7UH, UK
    Plant Cell Rep 28:1769-80. 2009
    ..We will also compare the genomic organization of sulfate assimilation in the model plant Arabidopsis thaliana with other plant species to find common and species-specific features of the pathway...
  27. ncbi Morin sulfates/glucuronides exert anti-inflammatory activity on activated macrophages and decreased the incidence of septic shock
    Shih Hua Fang
    Department of Microbiology, School of Medicine, China Medical University, Taichung 404, Taiwan
    Life Sci 74:743-56. 2003
    ..In this study, the effects of morin and its sulfates/glucuronides on the production of nitric oxide (NO) and cytokines from lipopolysaccharide (LPS)-activated ..
  28. pmc Drug targets in mycobacterial sulfur metabolism
    Devayani P Bhave
    Chemical Biology Ph D Program, University of Michigan, Ann Arbor, Michigan, 48109 2216, USA
    Infect Disord Drug Targets 7:140-58. 2007
    ..In this light, we also summarize recent progress in the development of inhibitors of sulfur metabolism enzymes...
  29. ncbi The biology and enzymology of protein tyrosine O-sulfation
    Kevin L Moore
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, The Department of Medicine, University of Oklahoma Health Sciences Center, USA
    J Biol Chem 278:24243-6. 2003
  30. ncbi Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats
    Elisabeth Wenzel
    German Research Center for Food Chemistry, Garching, Germany
    Mol Nutr Food Res 49:482-94. 2005
    ..The lack of effect on the chemopreventive parameters is probably due to the formation of various resveratrol conjugates reducing its bioavailability in the rat...
  31. ncbi Bacterial diversity and activity along a salinity gradient in soda lakes of the Kulunda Steppe (Altai, Russia)
    Mirjam J Foti
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Extremophiles 12:133-45. 2008
    ..Furthermore, the increase of sodium carbonate/bicarbonate seemed to affect the composition of the microbial community in soda lakes, but not the rate of sulfate reduction...
  32. pmc Candidate sulfonated and sulfated topical microbicides: comparison of anti-human immunodeficiency virus activities and mechanisms of action
    Irini A Scordi-Bello
    Department of Medicine, Mount Sinai School of Medicine, Box 1090, New York, NY 10029, USA
    Antimicrob Agents Chemother 49:3607-15. 2005
    ..When mixed with cervicovaginal lavage fluid, SPs maintain inhibitory activity at concentrations achievable in formulations...
  33. pmc Mitosomes in Entamoeba histolytica contain a sulfate activation pathway
    Fumika Mi-ichi
    Department of Parasitology, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    Proc Natl Acad Sci U S A 106:21731-6. 2009
    ..These results suggest that sulfate activation is the major function of mitosomes in E. histolytica and that E. histolytica mitosomes represent a unique mitochondrion-related organelle with remarkable diversity...
  34. ncbi Novel microbial communities of the Haakon Mosby mud volcano and their role as a methane sink
    Helge Niemann
    Max Planck Institute for Marine Microbiology, 28359 Bremen, Germany
    Nature 443:854-8. 2006
    ..This mechanism limits the capacity of the microbial methane filter at active marine mud volcanoes to <40% of the total flux...
  35. ncbi Antioxidant activity of different sulfate content derivatives of polysaccharide extracted from Ulva pertusa (Chlorophyta) in vitro
    Huimin Qi
    Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China
    Int J Biol Macromol 37:195-9. 2005
    ..Thirdly, HU4 (sulfate content, 30.8%) and HU5 (sulfate content, 32.8%) showed more pronounce chelating ability on ferrous ion at high concentration than other samples...
  36. ncbi In vitro demonstration of anaerobic oxidation of methane coupled to sulphate reduction in sediment from a marine gas hydrate area
    Katja Nauhaus
    Max Planck Institut für Marine Mikrobiologie, D 28359 Bremen, Germany
    Environ Microbiol 4:296-305. 2002
    ..Hence, the experiments did not provide evidence for one of these compounds acting as a free extracellular intermediate (intercellular shuttle) during AOM by the presently investigated consortia...
  37. ncbi Towards the phylogeny of APS reductases and sirohaem sulfite reductases in sulfate-reducing and sulfur-oxidizing prokaryotes
    W M Hipp
    Institut für Mikrobiologie and Biotechnologie, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    Microbiology 143:2891-902. 1997
    ..The aprA gene was demonstrated to be a suitable DNA probe for the identification of apr genes from organisms of different phylogenetic positions. PCR primers and conditions for the amplification of apr homologous regions are described...
  38. pmc The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism
    Kathryne S Auernik
    Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695 7905, USA
    Appl Environ Microbiol 74:682-92. 2008
    ..Many hypothetical proteins were also differentially transcribed, indicating that aspects of the iron and sulfur metabolism of M. sedula remain to be identified and characterized...
  39. pmc Multiple lateral transfers of dissimilatory sulfite reductase genes between major lineages of sulfate-reducing prokaryotes
    M Klein
    Lehrstuhl fur Mikrobiologie, Technische Universitat Munchen, D 85350 Freising, Germany
    J Bacteriol 183:6028-35. 2001
    ....
  40. doi Structure and mechanism of an inverting alkylsulfatase from Pseudomonas sp. DSM6611 specific for secondary alkyl sulfates
    Tanja Knaus
    Institute of Biochemistry, Graz University of Technology, Graz, Austria
    FEBS J 279:4374-84. 2012
    ..from Pseudomonas aeruginosa (SdsA1), Pisa1 showed a preference for secondary rather than primary alkyl sulfates, and enantioselectively hydrolyzed the (R)-enantiomer of rac-2-octyl sulfate, yielding (S)-2-octanol with ..
  41. pmc Sulfated steroids as natural ligands of mouse pheromone-sensing neurons
    Francesco Nodari
    Department of Anatomy and Neurobiology, School of Medicine, Washington University in St Louis, St Louis, Missouri 63110, USA
    J Neurosci 28:6407-18. 2008
    ..These results provide an unprecedented characterization of the signals available for chemical communication among mice...
  42. pmc 6-Sulphated chondroitins have a positive influence on axonal regeneration
    Rachel Lin
    Department of Clinical Neurosciences, Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e21499. 2011
    ....
  43. doi Seasonal and cell type specific expression of sulfate transporters in the phloem of Populus reveals tree specific characteristics for SO(4)(2-) storage and mobilization
    Jasmin Dürr
    Chair of Tree Physiology, Institute of Forest Botany and Tree Physiology, Albert Ludwigs University Freiburg, Georges Köhler Allee 053 054, 79110 Freiburg, Germany
    Plant Mol Biol 72:499-517. 2010
    ..However, PtaSULTR1;1 abundance correlated negatively with sulfate content in leaves, supporting its function in phloem loading. Taken together, these findings indicate a transcriptional regulation of sulfate distribution in poplar trees...
  44. doi Desulfovibrio piezophilus sp. nov., a piezophilic, sulfate-reducing bacterium isolated from wood falls in the Mediterranean Sea
    Saber Khelaifia
    IRD, UMR 180, IFR BAIM, Universités de Provence et de la Méditerranée, ESIL case 925, 163 Avenue de Luminy, F 13288 Marseille Cedex 9, France
    Int J Syst Evol Microbiol 61:2706-11. 2011
    ..nov...
  45. pmc Disruption of adenosine-5'-phosphosulfate kinase in Arabidopsis reduces levels of sulfated secondary metabolites
    Sarah G Mugford
    Department of Metabolic Biology, John Ines Centre, Norwich, Norfolk NR4 7UH, United Kingdom
    Plant Cell 21:910-27. 2009
    ..The data indicate that the APK1 and APK2 isoforms of APS kinase play a major role in the synthesis of secondary sulfated metabolites and are required for normal growth rates...
  46. doi Regulation of sulfate uptake and assimilation--the same or not the same?
    Jean Claude Davidian
    Unite Mixte de Recherche, Biochimie et Physiologie Moleculaire des Plantes, Montpellier SupAgro CNRS INRA UM2, 2 Place Pierre Viala, 34060 Montpellier Cedex 2, France
    Mol Plant 3:314-25. 2010
    ..Here, we review the current knowledge on regulation of these processes, with special attention given to similarities and differences...
  47. ncbi Iron corrosion by novel anaerobic microorganisms
    Hang T Dinh
    Max Planck Institute for Marine Microbiology, Celsiusstrasse 1, 28359 Bremen, Germany
    Nature 427:829-32. 2004
    ..Similarly, a newly isolated Methanobacterium-like archaeon produced methane with iron faster than do known hydrogen-using methanogens, again suggesting a more direct access to electrons from iron than via hydrogen consumption...
  48. pmc Microbial links between sulfate reduction and metal retention in uranium- and heavy metal-contaminated soil
    Jana Sitte
    Institute of Ecology, Friedrich Schiller University Jena, D 07743 Jena, Germany
    Appl Environ Microbiol 76:3143-52. 2010
    ..Our results suggest that (i) ongoing sulfate reduction in contaminated soil resulted in in situ metal attenuation and (ii) the fate of uranium mobility is not predictable and may lead to downstream contamination of adjacent ecosystems...
  49. doi The sulfate transporter family in wheat: tissue-specific gene expression in relation to nutrition
    Peter Buchner
    Rothamsted Research, Plant Science Department, West Common, Harpenden, Hertfordshire, UK
    Mol Plant 3:374-89. 2010
    ....
  50. doi How sulphate-reducing microorganisms cope with stress: lessons from systems biology
    Jizhong Zhou
    Stephenson Research and Technology Center, 101 David L Boren Blvd, Institut for Environmental Genomics and Department of Botany and Microbiology, University of Oklahoma, Norman, Oklahoma 73019, USA
    Nat Rev Microbiol 9:452-66. 2011
    ....
  51. ncbi Deposition and cycling of sulfur controls mercury accumulation in Isle Royale fish
    Paul E Drevnick
    Department of Zoology, Miami University, Oxford, Ohio 45056, USA
    Environ Sci Technol 41:7266-72. 2007
    ..Therefore, reductions in anthropogenic sulfur emissions may provide a synergistic solution to the mercury problem in sulfate-limited freshwaters...
  52. pmc The 3'-phosphoadenosine 5'-phosphosulfate transporters, PAPST1 and 2, contribute to the maintenance and differentiation of mouse embryonic stem cells
    Norihiko Sasaki
    Laboratory of Cell Biology, Department of Bioinformatics, Faculty of Engineering, Soka University, Hachioji, Tokyo, Japan
    PLoS ONE 4:e8262. 2009
    ..We propose that PAPST-dependent sulfation of HS or CS chains, which is regulated developmentally, regulates the extrinsic signaling required for the maintenance and normal differentiation of mESCs...
  53. ncbi Old age and gender influence the pharmacokinetics of inhaled manganese sulfate and manganese phosphate in rats
    David C Dorman
    CIIT Centers for Health Research, Research Triangle Park, NC 27709 2137, USA
    Toxicol Appl Pharmacol 197:113-24. 2004
    ..Data from this study should prove useful in developing dosimetry models for manganese that consider age or gender as potential sensitivity factors...
  54. ncbi Regulation of sulphate assimilation by glutathione in poplars (Populus tremula x P. alba) of wild type and overexpressing gamma-glutamylcysteine synthetase in the cytosol
    Tanja Hartmann
    Albert Ludwigs University of Freiburg, Institute of Forest Botany and Tree Physiology, Georges Köhler Allee 053, D 79110 Freiburg, Germany
    J Exp Bot 55:837-45. 2004
    ..However, OAS measurements revealed that OAS cannot be the only signal responsible for the lack of feedback regulation of APR by GSH in the transgenic poplars...
  55. ncbi Anticoagulant properties of a sulfated galactan preparation from a marine green alga, Codium cylindricum
    K Matsubara
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, 719 1197, Okayama, Japan
    Int J Biol Macromol 28:395-9. 2001
    ..The anticoagulant did not potentiate antithrombin III (AT III) and heparin cofactor II (HC II), thus the anticoagulant mechanism would be different from that of other anticoagulants isolated so far from the genus Codium...
  56. ncbi Structure and antiviral activity of sulfated fucans from Stoechospermum marginatum
    Utpal Adhikari
    Natural Products Laboratory, Department of Chemistry, The University of Burdwan, Golapbag, Burdwan, West Bengal 713 104, India
    Phytochemistry 67:2474-82. 2006
    ..No direct inactivating effect on virions was observed in a virucidal assay. The absence of anticoagulant activity at concentrations near EC50 confirmed that there was no correlation between the antiviral and anticoagulant properties...
  57. pmc Molecular characterization of sulfate-reducing bacteria in the Guaymas Basin
    Ashita Dhillon
    Marine Biological Laboratory, The Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, NASA Astrobiology Institute, 7 MBL Street, Woods Hole, MA 02543, USA
    Appl Environ Microbiol 69:2765-72. 2003
    ..In addition, the dsrAB sequencing approach revealed a novel group of sulfate-reducing prokaryotes that could not be identified by 16S rRNA sequencing...
  58. ncbi Sulfated polysaccharides from the red seaweed Georgiella confluens
    Adriana A Kolender
    Departamento de Quimica Organica, CIHIDECAR CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellon 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina
    Carbohydr Res 337:57-68. 2002
    ....
  59. ncbi Anti-herpes simplex virus activity of sulfated galactans from the red seaweeds Gymnogongrus griffithsiae and Cryptonemia crenulata
    Laura B Talarico
    Laboratorio de Virologia, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon 2, 1428 Buenos Aires, Argentina
    Int J Biol Macromol 34:63-71. 2004
    ..Most importantly, a significant protection against a murine vaginal infection with HSV-2 was afforded by topical treatment with the sulfated galactans...
  60. ncbi The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans
    Maria E R Duarte
    Departamento de Bioquimica e Biologia Molecular, Universidade Federal do Parana, P O Box 19046, CEP 81531 990, Curitiba, Parana, Brazil
    Carbohydr Res 339:335-47. 2004
    ..Rhodomelaceae, Ceramiales), is made up of A-units highly substituted with sulfate groups on C-2 (28-30%), sulfates on C-2 and 4,6-O-(1'-carboxyethylidene) groups (9-15%), and only the C-2 sulfate groups (5-8%) with small amounts ..
  61. pmc A Sinorhizobium meliloti lipopolysaccharide mutant altered in cell surface sulfation
    David H Keating
    Howard Hughes Medical Institute Department of Biology, Stanford University, Stanford, California 94305, USA
    J Bacteriol 184:6681-9. 2002
    ..Finally, we determined that the lps-212 mutation resulted in a reduced ability to elicit the formation of plant nodules and by altered infection thread structures that aborted prematurely...
  62. pmc Heterofucans from the brown seaweed Canistrocarpus cervicornis with anticoagulant and antioxidant activities
    Rafael Barros Gomes Camara
    Laboratory of Biotechnology of Natural Polymers, Department of Biochemistry, Federal University of Rio Grande do Norte, Natal RN, Brazil
    Mar Drugs 9:124-38. 2011
    ..cervicornis polysaccharides as anticoagulants and antioxidants. Further purification steps and additional studies on structural features as well as in vivo experiments are needed to test the viability of their use as therapeutic agents...
  63. ncbi A fucoidan fraction from Ascophyllum nodosum
    M F Marais
    , , BP 53, F-38041, Grenoble, France
    Carbohydr Res 336:155-9. 2001
    ..Such diversity in the structural features of this fucoidan may be of importance for its various biological properties...
  64. doi Structural characteristics and in vitro macrophage activation of acetyl fucoidan from Cladosiphon okamuranus
    Takeshi Teruya
    The United Graduate School of Agricultural Sciences, Kagoshima University, 1 21 24, Korimoto, Kagoshima 890 0065, Japan
    Glycoconj J 26:1019-28. 2009
    ..The results suggested that CAF induced macrophage activation through membrane receptors TLR4, CD14 and SRA, and MAPK signaling pathways...
  65. ncbi Isolation and characterization of a sulfated polysaccharide from the brown alga Sargassum patens and determination of its anti-herpes activity
    Wen Zhu
    Department of Biology, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Biochem Cell Biol 81:25-33. 2003
    ..3, 5.5, and 4.1 microg/mL, respectively. The 50% cytotoxic concentration (CC50) of SP-2a on the growth of normal Vero cell line was more than 4000 microg/mL. Therefore SP-2a of S. patens may be a potent agent for treating HSV infections...
  66. doi Structural and functional insights into sulfated galactans: a systematic review
    Vitor H Pomin
    Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA
    Glycoconj J 27:1-12. 2010
    ..This review will present an overview about the principle structural and functional information of SGs. Other important aspects concerning occurrence, biology, phylogeny, and future directions, will also be reported...
  67. pmc Sulfate assimilation in eukaryotes: fusions, relocations and lateral transfers
    Nicola J Patron
    School of Botany, University of Melbourne, Victoria 3010, Australia
    BMC Evol Biol 8:39. 2008
    ....
  68. ncbi Physiological roles and regulation of mammalian sulfate transporters
    D Markovich
    Department of Physiology and Pharmacology, University of Queensland, Brisbane, Queensland, Australia
    Physiol Rev 81:1499-533. 2001
    ....
  69. ncbi Biology and function of the reversible sulfation pathway catalysed by human sulfotransferases and sulfatases
    M W Coughtrie
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, UK
    Chem Biol Interact 109:3-27. 1998
    ..The genetic and environmental factors which are known to influence the activity and expression of human SULTs and sulfatases are also reviewed...
  70. doi Unequal functional redundancy between the two Arabidopsis thaliana high-affinity sulphate transporters SULTR1;1 and SULTR1;2
    Marie Barberon
    Centre International d Etudes Supérieures en Sciences Agronomiques, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Universite Montpellier II, Montpellier, France
    New Phytol 180:608-19. 2008
    ..The SULTR1;1 and SULTR1;2 genes display unequal functional redundancy, which leaves open for SULTR1;1 the possibility of displaying an additional function besides its role in sulphate membrane transport...
  71. ncbi Thermodesulfobacterium hydrogeniphilum sp. nov., a thermophilic, chemolithoautotrophic, sulfate-reducing bacterium isolated from a deep-sea hydrothermal vent at Guaymas Basin, and emendation of the genus Thermodesulfobacterium
    Christian Jeanthon
    UMR 6539, Centre National de la Recherche Scientifique and Université de Bretagne Occidentale, Institut Universitaire Europeen de la Mer, Plouzane, France
    Int J Syst Evol Microbiol 52:765-72. 2002
    ..nov. The type strain is SL6T (= DSM 14290T = JCM 11239T). Because of the phenotypic characteristics of the novel species, it is also proposed that the description of the genus Thermodesulfobacterium requires emendation...
  72. ncbi Leaf developmental stage affects sulfate depletion and specific sulfate transporter expression during sulfur deprivation in Brassica napus L
    S Parmar
    Department of Plant Sciences, Rothamsted Research, West Common, Harpenden, Hertfordshire AL5 2JQ, UK
    Plant Biol (Stuttg) 9:647-53. 2007
    ..Expression patterns indicated that both differences in intracellular sulfate pools and localised aspects of the signal transduction pathway link tissue sulfate-status and sulfur-nutrition regulated gene expression...
  73. ncbi Proteoglycan sulfation in cartilage and cell cultures from patients with sulfate transporter chondrodysplasias: relationship to clinical severity and indications on the role of intracellular sulfate production
    A Rossi
    Department of Biochemistry Alessandro Castellani, University of Pavia, Italy
    Matrix Biol 17:361-9. 1998
    ....
  74. ncbi A disaccharide repeat unit is the major structure in fucoidans from two species of brown algae
    L Chevolot
    Laboratoire de Recherches sur les Macromolecules, Unité de Recherche Marine 2 et Unité Mixte de Recherche CNRS 7540, Universite Paris Nord, Villetaneuse, France
    Carbohydr Res 330:529-35. 2001
    ..The fraction LMWF has in vitro anticoagulant activity, indicating that the above structure may be partly responsible for biological activity in the native fucoidan...
  75. ncbi Human multidrug resistance protein 8 (MRP8/ABCC11), an apical efflux pump for steroid sulfates, is an axonal protein of the CNS and peripheral nervous system
    M Bortfeld
    Division of Tumor Biochemistry, German Cancer Research Center, University of Heidelberg, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Neuroscience 137:1247-57. 2006
    ..the integral membrane protein ABCC11 (multidrug resistance protein 8) as an ATP-dependent efflux pump for steroid sulfates, including dehydroepiandrosterone 3-sulfate, and localize it to axons of the human CNS and peripheral nervous ..
  76. pmc The effects of components of fine particulate air pollution on mortality in california: results from CALFINE
    Bart Ostro
    Office of Environmental Health Hazard Assessment, 16th Floor, 1515 Clay St, Oakland, CA 94612, USA
    Environ Health Perspect 115:13-9. 2007
    ..5 pm in diameter (PM2.5). Little is known, however, about the relative effects of PM2.5 constituents. We examined associations between 19 PM2.5 components and daily mortality in six California counties...
  77. ncbi The antiviral activity of sulfated polysaccharides against dengue virus is dependent on virus serotype and host cell
    L B Talarico
    Laboratorio de Virologia, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
    Antiviral Res 66:103-10. 2005
    ..Therefore, the variations in antiviral activity of the polysaccharides depending on the viral serotype and the host cell may be ascribed to differences in the virus-cell interaction leading to virus entry...
  78. ncbi Molecular mechanisms of phosphate and sulphate transport in plants
    F W Smith
    CSIRO Tropical Agriculture, Cunningham Laboratory, 306 Carmody Road, St Lucia, Australia
    Biochim Biophys Acta 1465:236-45. 2000
    ..These data, together with functional characterisation of the transporters, are enabling the roles of various transporters in the overall phosphate and sulphate nutrition of plants to be defined...
  79. pmc Phylogenetic analysis reveals multiple lateral transfers of adenosine-5'-phosphosulfate reductase genes among sulfate-reducing microorganisms
    Michael W Friedrich
    Max Planck Institute for Terrestrial Microbiology, D 35043 Marburg, Germany
    J Bacteriol 184:278-89. 2002
    ..Bacteriol. 183:6028-6035, 2001), was also amplified and sequenced. Phylogenetic comparison of DsrAB- and ApsA-based trees suggests a frequent involvement of gram-positive and thermophilic SRB in lateral gene transfer events among SRB...
  80. ncbi Effect of glucose on assimilatory sulphate reduction in Arabidopsis thaliana roots
    Holger Hesse
    Max Planck Institute for Molecular Plant Physiology, Department of Molecular Physiology, Am Muehlenberg 1, D 14476 Golm, Germany
    J Exp Bot 54:1701-9. 2003
    ..Furthermore, signals originating from nitrogen and carbon metabolism regulate APR synergistically...
  81. pmc Combined genomic and proteomic approaches identify gene clusters involved in anaerobic 2-methylnaphthalene degradation in the sulfate-reducing enrichment culture N47
    Drazenka Selesi
    Institute of Groundwater Ecology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    J Bacteriol 192:295-306. 2010
    ..The present work provides the first insight into the genetic basis of anaerobic 2-methylnaphthalene metabolism and delivers implications for understanding contaminant degradation...
  82. ncbi Reverse methanogenesis: testing the hypothesis with environmental genomics
    Steven J Hallam
    Monterey Bay Aquarium Research Institute, Moss Landing, CA 95064, USA
    Science 305:1457-62. 2004
    ..These genome-based observations support previous hypotheses and provide an informed foundation for metabolic modeling of anaerobic methane oxidation...
  83. pmc Complex signaling network in regulation of adenosine 5'-phosphosulfate reductase by salt stress in Arabidopsis roots
    Anna Koprivova
    Department of Metabolic Biology, John Innes Centre, Norwich, UK
    Plant Physiol 146:1408-20. 2008
    ..These results demonstrate an extensive posttranscriptional regulation of plant APR and reveal that the sulfate assimilation pathway is controlled by a complex network of multiple signals on different regulatory levels...
  84. ncbi Isotopic evidence for microbial sulphate reduction in the early Archaean era
    Y Shen
    Danish Center for Earth System Science, and Institute of Biology, Odense University, SDU
    Nature 410:77-81. 2001
    ....
  85. pmc Cadmium-induced sulfate uptake in maize roots
    Fabio F Nocito
    Dipartimento di Produzione Vegetale, Universita degli Studi di Milano, Via Celoria 2, 20133 Milano, Italy
    Plant Physiol 129:1872-9. 2002
    ....
  86. doi Enrichment of anaerobic methanotrophs in sulfate-reducing membrane bioreactors
    Roel J W Meulepas
    Sub Department of Environmental Technology, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    Biotechnol Bioeng 104:458-70. 2009
    ....
  87. doi Application of bacteria involved in the biological sulfur cycle for paper mill effluent purification
    Albert J H Janssen
    Sub Department of Environmental Technology, Wageningen University, Wageningen, The Netherlands
    Sci Total Environ 407:1333-43. 2009
    ..The sludge was also successfully used in investigation on sulfate reduction with carbon monoxide as the electron donor and the conversion of methanethiol. This shows the biotechnological potential of this complex reactor biomass...
  88. doi The chloroplast sulfate transport system in the green alga Chlamydomonas reinhardtii
    Pia Lindberg
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720 3102, USA
    Planta 228:951-61. 2008
    ..reinhardtii, specifically recognized by polyclonal antibodies against SulP and Sabc. These results suggest the presence and function in C. reinhardtii of a Sbp-SulP-SulP2-Sabc chloroplast envelope sulfate transporter holocomplex...
  89. pmc Sultr4;1 mutant seeds of Arabidopsis have an enhanced sulphate content and modified proteome suggesting metabolic adaptations to altered sulphate compartmentalization
    Hélène Zuber
    UMR102 Genetics and Ecophysiology of Grain Legumes, INRA, F 21000 Dijon, France
    BMC Plant Biol 10:78. 2010
    ..The low-affinity sulphate transporters SULTR4;1 and SULTR4;2 have been localized to the vacuolar membrane, where they may facilitate sulphate efflux from the vacuole...
  90. pmc Propionate and butyrate dependent bacterial sulfate reduction at extremely haloalkaline conditions and description of Desulfobotulus alkaliphilus sp. nov
    D Y Sorokin
    Winogradsky Institute of Microbiology, Russian Academy of Sciences, Prospect 60 let Octyabrya 7 2, 117811, Moscow, Russia
    Extremophiles 14:71-7. 2010
    ..The strain represents the first haloalkaliphilic representative of the family Desulfobacteraceae and is described as Desulfobotulus alkaliphilus sp. nov...
  91. ncbi Sulphate respiration from hydrogen in Desulfovibrio bacteria: a structural biology overview
    Pedro M Matias
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Apartado 127, 2781 901 Oeiras, Portugal
    Prog Biophys Mol Biol 89:292-329. 2005
    ..Therefore, a thorough understanding of the sulphate respiratory chain in Desulfovibrio remains a challenging task...
  92. doi Anti-herpetic activity of a sulfated xylomannan from Scinaia hatei
    Pinaki Mandal
    Natural Products Laboratory, Department of Chemistry, The University of Burdwan, Golapbag, Burdwan, West Bengal 713 104, India
    Phytochemistry 69:2193-9. 2008
    ..Sulfate groups, when present, are located at C-4 of alpha-(1-->3)-linked D-mannopyranosyl units, and appeared to be very important for the anti-herpetic activity of this polymer...
  93. pmc The dual transcriptional regulator CysR in Corynebacterium glutamicum ATCC 13032 controls a subset of genes of the McbR regulon in response to the availability of sulphide acceptor molecules
    Christian Ruckert
    Institut für Systembiologie and Genomforschung, Universitat Bielefeld, Universitatsstr 25, D 33615 Bielefeld, Germany
    BMC Genomics 9:483. 2008
    ..Therefore, it is an interesting candidate for study to further the understanding of the regulation of sulphur metabolism in C. glutamicum...
  94. ncbi Uranium immobilization by sulfate-reducing biofilms
    Haluk Beyenal
    Center for Biofilm Engineering and Department of Civil Engineering, Montana State University, Bozeman, Montana 59717 3980, USA
    Environ Sci Technol 38:2067-74. 2004
    ..Selected-area electron diffraction pattern and crystallographic analysis of transmission electron microscope lattice-fringe images confirmed the structure of precipitated U as being that of uraninite...
  95. ncbi Low marine sulphate and protracted oxygenation of the Proterozoic biosphere
    Linda C Kah
    Department of Earth and Planetary Sciences, University of Tennessee, Knoxville, Tennessee 37996, USA
    Nature 431:834-8. 2004
    ....
  96. pmc Hyposulfatemia, growth retardation, reduced fertility, and seizures in mice lacking a functional NaSi-1 gene
    Paul A Dawson
    School of Biomedical Sciences, University of Queensland, Brisbane 4072, Australia
    Proc Natl Acad Sci U S A 100:13704-9. 2003
    ..Spontaneous clonic seizures were observed in Nas1-/- mice from 8 months of age. These data demonstrate NaSi-1 is essential for maintaining sulfate homeostasis, and its expression is necessary for a wide range of physiological functions...
  97. pmc Structure-activity relationships for hydroxylated polychlorinated biphenyls as substrates and inhibitors of rat sulfotransferases and modification of these relationships by changes in thiol status
    Yungang Liu
    Division of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA
    Drug Metab Dispos 37:1065-72. 2009
    ..This alteration in specificity of rSULT1A1 for certain OH-PCBs suggests that conditions of oxidative stress may significantly alter the sulfation of some OH-PCBs in the rat...
  98. pmc The seed composition of Arabidopsis mutants for the group 3 sulfate transporters indicates a role in sulfate translocation within developing seeds
    Hélène Zuber
    INRA, UMR102 Genetics and Ecophysiology of Grain Legumes, Dijon, France
    Plant Physiol 154:913-26. 2010
    ..Metabolic adjustments were also revealed, some of which could release sulfur from glucosinolates...
  99. ncbi Heparan sulfates expressed in the distal lung are required for Fgf10 binding to the epithelium and for airway branching
    Konstantin I Izvolsky
    Pulmonary Ctr, Boston Univ School of Medicine, 80 E Concord St R 304, Boston, MA 02118, USA
    Am J Physiol Lung Cell Mol Physiol 285:L838-46. 2003
    ..Here we use an immunohistochemistry-based binding assay to show that O-sulfated heparan sulfates (HS) are critical for Fgf10 binding to the distal epithelium...
  100. pmc Tyrosine sulfation is prevalent in human chemokine receptors important in lung disease
    Justin Liu
    Section of Neurobiology, Physiology and Behavior, University of California, Davis, 1 Shields Avenue, Davis, CA 95616, USA
    Am J Respir Cell Mol Biol 38:738-43. 2008
    ..Recognition that tyrosine sulfation is found in most clinically relevant chemokine receptors could help the development of specific receptor-ligand antagonists to modulate events important in airway diseases...
  101. ncbi The role of soluble components in ambient fine particles-induced changes in human lungs and blood
    Yuh Chin T Huang
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC, USA
    Inhal Toxicol 15:327-42. 2003
    ....

Research Grants68

  1. SYNTHESIS OF GLYCOSAMINOGLYCAN OLIGOSACCHARIDES
    Robert Linhardt; Fiscal Year: 2004
    ..Heparin, heparan sulfate, chondroitin sulfates, dermatan sulfate, and hyaluronic acid are all members of this family...
  2. Chemoenzymatic Synthesis of Glycosaminoglycan Oligos
    Robert Linhardt; Fiscal Year: 2009
    ..Heparin, heparan sulfate, chondroitin sulfates, dermatan sulfate, and hyaluronic acid are all members of this family...
  3. Chemoenzymatic Synthesis of Glycosaminoglycan Oligos
    Robert Linhardt; Fiscal Year: 2007
    ..Heparin, heparan sulfate, chondroitin sulfates, dermatan sulfate, and hyaluronic acid are all members of this family...
  4. MUCOPOLYSACCHARIDOSES AND CATHEPSIN K
    Dieter Bromme; Fiscal Year: 2007
    ..Chondroitin- and keratan sulfates enhance the collagenolytic activity of the protease, while dermatan and heparan sulfates are potent inhibitors...
  5. Correction of neural abnormalities in Hurler syndrome
    Pankaj Gupta; Fiscal Year: 2003
    ..They will compare the structure and binding properties of heparan sulfates from Hurler and normal MSC, identify the mechanism(s) by which abnormal glycosaminoglycas in Hurler cells lead to ..
  6. STRUCTURE OF ANTIMITOGENIC MESANGIAL HEPARAN SULFATES
    Aimin Wang; Fiscal Year: 2002
    DESCRIPTION (adapted from the application) Heparan sulfates (HSs) and heparin, proposed as endogenous defending molecules in the "glomerular self-defense", are inhibitors of mesangial cell growth in human proliferative nephritides, in ..
  7. IN VIVO ROLE OF PROTEOGLYCANS IN GROWTH FACTOR SIGNALING
    J Marsh; Fiscal Year: 2001
    ..Following this, we have also found that mutations in the Drosophila syndecan gene, a major source of heparan sulfates in vertebrates, interact genetically with mutations of dishevelled, a key component of the wingless signaling ..
  8. CARCINOGENESIS: HIGHLY REACTIVE NITROSAMINES
    RICHARD LOEPPKY; Fiscal Year: 1993
    ..The resulting sulfates are expected to rapidly produce reactive 3-alkyl-5-hydroxy-1,2,3,- oxadiazolinium ions, which upon proton loss ..
  9. Stereoselective Atom Transfer
    KARL BARRY SHARPLESS; Fiscal Year: 2010
    ..Chief among these are epoxides, aziridines, cyclic sulfates, and episulfonium ions. New methods for the synthesis and manipulation of these intermediates are discussed...
  10. MATRIX METALLOPROTEINASES AND NEURONS IN FOCAL ISCHEMIA
    Gregory Del Zoppo; Fiscal Year: 2007
    ..preliminary data, we propose that enzymes which degrade matrix heparan sulfate proteoglycans (HSPGs) and heparan sulfates (HSs) are generated following MCA:O, simultaneously with the matrix metalloproteinase pro-MMP-2, and are ..