unithiol

Summary

Summary: A chelating agent used as an antidote to heavy metal poisoning.

Top Publications

  1. ncbi Mercury elimination with oral DMPS, DMSA, vitamin C, and glutathione: an observational clinical review
    Peter J Muran
    Longevity Healthcare Center, San Luis Obispo, CA, USA
    Altern Ther Health Med 12:70-5. 2006
  2. ncbi The Mt. Diwata study on the Philippines 2000-treatment of mercury intoxicated inhabitants of a gold mining area with DMPS (2,3-dimercapto-1-propane-sulfonic acid, Dimaval)
    S Bose-O'Reilly
    Institute of Forensic Medicine, Ludwig Maximilians University, Munich, Germany
    Sci Total Environ 307:71-82. 2003
  3. pmc Mobilization of mercury and arsenic in humans by sodium 2,3-dimercapto-1-propane sulfonate (DMPS)
    H V Aposhian
    Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721 0106, USA
    Environ Health Perspect 106:1017-25. 1998
  4. ncbi Effects of BSO, GSH, Vit-C and DMPS on the nephrotoxicity of mercury
    Zhaofa Xu
    Department of Environmental Health, School of Public Health, China Medical University, Shenyang, People s Republic of China
    Toxicol Ind Health 23:403-10. 2007
  5. ncbi Anticopper efficacy of captopril and sodium dimercaptosulphonate in patients with Wilson's disease
    Xiao Ping Wang
    College of Life Sciences, University of Science and Technology of China, Hefei, PR China
    Funct Neurol 18:149-53. 2003
  6. ncbi Severe acute copper sulphate poisoning: a case report
    Andreja Sinkovic
    Maribor Teaching Hospital, Maribor, Slovenia
    Arh Hig Rada Toksikol 59:31-5. 2008
  7. ncbi 2,3-Dimercaptopropanol, 2,3-dimercaptopropane-1-sulfonic acid, and meso-2,3-dimercaptosuccinic acid inhibit delta-aminolevulinate dehydratase from human erythrocytes in vitro
    C W Nogueira
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria CEP 97105 900, RS, Brazil
    Environ Res 94:254-61. 2004
  8. ncbi Dental amalgam affects urinary selenium excretion
    Paul Johan Høl
    Department of Odontology Dental Biomaterials, University of Bergen, Norway
    Biol Trace Elem Res 85:137-47. 2002
  9. ncbi Vanadium detoxification: on the interaction of oxovanadium(IV) and other vanadium species with 2,3-dimercapto-1-propanesulfonate
    Patricia A M Williams
    Centro de Quimica Inorganica CEQUINOR CONICET, UNLP, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, C Correo 962, 1900 La Plata, Argentina
    J Inorg Biochem 102:1195-8. 2008
  10. ncbi Fanconi's syndrome, acute renal failure, and tonsil ulcerations after colloidal bismuth subcitrate intoxication
    Petr Hruz
    Department of Internal Medicine Clinic B, Division of Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
    Am J Kidney Dis 39:E18. 2002

Research Grants

  1. Dense Medium Plasma Remediation of VOCs in Groundwater
    Yonghui Ma; Fiscal Year: 2007
  2. RENAL TRANSPORT OF ORGANIC CHELATORS OF HEAVY METALS
    Stephen Wright; Fiscal Year: 2004
  3. Leptin Control of Obesity
    Mary Clark; Fiscal Year: 2005
  4. MERCURY NEPHROTOXICITY AFTER A REDUCTION OF RENAL MASS
    RUDOLFS ZALUPS; Fiscal Year: 2002
  5. TRANSPORT AND TOXICITY OF MERCURY IN THE NEPHRON
    RUDOLFS ZALUPS; Fiscal Year: 2006
  6. METALLOTHIONEIN, MERCURY AND MONOCYTE ACTIVATION
    RUDOLFS ZALUPS; Fiscal Year: 2006
  7. MECHANISMS FOR RENAL UPTAKE OF MERCURY
    CHRISTY BRIDGES; Fiscal Year: 2005
  8. Role of Multidrug Resistance Proteins 2 and/or 4, and DMPS and DMSA in the Renal
    CHRISTY BRIDGES; Fiscal Year: 2008
  9. 2D Nano-flow Mass Spectrometry System
    ELIZABETH KOMIVES; Fiscal Year: 2006
  10. BIOPHYSICAL STUDIES OF LRP LIGANDS INTERACTIONS
    ELIZABETH KOMIVES; Fiscal Year: 2003

Detail Information

Publications211 found, 100 shown here

  1. ncbi Mercury elimination with oral DMPS, DMSA, vitamin C, and glutathione: an observational clinical review
    Peter J Muran
    Longevity Healthcare Center, San Luis Obispo, CA, USA
    Altern Ther Health Med 12:70-5. 2006
    ..This protocol yielded an average 69% reduction of urine mercury by provocation analysis...
  2. ncbi The Mt. Diwata study on the Philippines 2000-treatment of mercury intoxicated inhabitants of a gold mining area with DMPS (2,3-dimercapto-1-propane-sulfonic acid, Dimaval)
    S Bose-O'Reilly
    Institute of Forensic Medicine, Ludwig Maximilians University, Munich, Germany
    Sci Total Environ 307:71-82. 2003
    ..Adverse side effects were rarely reported. Only in one case the medication had to be terminated after the first application due to an allergic skin reaction...
  3. pmc Mobilization of mercury and arsenic in humans by sodium 2,3-dimercapto-1-propane sulfonate (DMPS)
    H V Aposhian
    Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721 0106, USA
    Environ Health Perspect 106:1017-25. 1998
    ..Because South American animals studied were deficient in arsenite methyltransferase, a hypothesis is presented that arsenite and arsenite methyltransferase may have had a role in the evolution of some South American animals...
  4. ncbi Effects of BSO, GSH, Vit-C and DMPS on the nephrotoxicity of mercury
    Zhaofa Xu
    Department of Environmental Health, School of Public Health, China Medical University, Shenyang, People s Republic of China
    Toxicol Ind Health 23:403-10. 2007
    ..To study the effects of BSO, GSH, Vit-C and DMPS on the nephrotoxicity of mercury...
  5. ncbi Anticopper efficacy of captopril and sodium dimercaptosulphonate in patients with Wilson's disease
    Xiao Ping Wang
    College of Life Sciences, University of Science and Technology of China, Hefei, PR China
    Funct Neurol 18:149-53. 2003
    ..The authors also discuss recent experience of the overall treatment in China...
  6. ncbi Severe acute copper sulphate poisoning: a case report
    Andreja Sinkovic
    Maribor Teaching Hospital, Maribor, Slovenia
    Arh Hig Rada Toksikol 59:31-5. 2008
    ..In addition, antidotes such as methylene blue for methaemoglobinaemia and chelating agent such as DMPS improve morbidity and survival of severely poisoned victims...
  7. ncbi 2,3-Dimercaptopropanol, 2,3-dimercaptopropane-1-sulfonic acid, and meso-2,3-dimercaptosuccinic acid inhibit delta-aminolevulinate dehydratase from human erythrocytes in vitro
    C W Nogueira
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria CEP 97105 900, RS, Brazil
    Environ Res 94:254-61. 2004
    ..ZnCl(2) (1 microM) added, in the reaction mixture, increased enzyme activity and DTT (100 microM) totally restored the enzyme activity for all chelating agents tested...
  8. ncbi Dental amalgam affects urinary selenium excretion
    Paul Johan Høl
    Department of Odontology Dental Biomaterials, University of Bergen, Norway
    Biol Trace Elem Res 85:137-47. 2002
    ..4 microg) and without (39.4 microg) amalgam-related symptoms (p = 0.15). The findings indicate that individuals exposed to low levels of elemental mercury from dental amalgam excrete less selenium to urine than unexposed individuals...
  9. ncbi Vanadium detoxification: on the interaction of oxovanadium(IV) and other vanadium species with 2,3-dimercapto-1-propanesulfonate
    Patricia A M Williams
    Centro de Quimica Inorganica CEQUINOR CONICET, UNLP, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, C Correo 962, 1900 La Plata, Argentina
    J Inorg Biochem 102:1195-8. 2008
    ..DMPS produces also the slow reduction of a V2O5 suspension at pH 7.1. The results of this study suggest that DMPS may be a potentially useful detoxification agent for vanadium...
  10. ncbi Fanconi's syndrome, acute renal failure, and tonsil ulcerations after colloidal bismuth subcitrate intoxication
    Petr Hruz
    Department of Internal Medicine Clinic B, Division of Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
    Am J Kidney Dis 39:E18. 2002
    ..Treatment with the chelating agent DMPS in combination with hemodialysis is highly effective in reducing the serum bismuth level in patients with acute renal failure...
  11. ncbi Lead-induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats
    Geetu Saxena
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    J Biochem Mol Toxicol 18:221-33. 2004
    ....
  12. ncbi DMPS and N-acetylcysteine induced renal toxicity in mice exposed to mercury
    Ricardo Brandão
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, 97105 900, Santa Maria, RS, Brazil
    Biometals 19:389-98. 2006
    ..In conclusion, therapies with (PhSe)2, DMPS and NAC following mercury exposure must be better studied because the formation of more toxic complexes with mercury, which can mainly damage renal tissue...
  13. ncbi Chelation in metal intoxication: influence of cysteine or N-acetyl cysteine on the efficacy of 2,3-dimercaptopropane-1-sulphonate in the treatment of cadmium toxicity
    Sushil K Tandon
    Chemical Toxicology, Industrial Toxicology Research Centre, Lucknow, India
    J Appl Toxicol 22:67-71. 2002
    ..The results have shown a limited benefit of cysteine or N-acetyl cysteine administration on the efficacy of DMPS in the treatment of cadmium intoxication...
  14. pmc MRP2 and the DMPS- and DMSA-mediated elimination of mercury in TR(-) and control rats exposed to thiol S-conjugates of inorganic mercury
    Christy C Bridges
    Mercer University School of Medicine, Division of Basic Medical Sciences, Macon, Georgia 31207, USA
    Toxicol Sci 105:211-20. 2008
    ..Overall, these data support our hypothesis that Mrp2 is involved in the DMPS and DMSA-mediated extraction of the body burden of Hg2+...
  15. ncbi Identification of a mechanism by which the methylmercury antidotes N-acetylcysteine and dimercaptopropanesulfonate enhance urinary metal excretion: transport by the renal organic anion transporter-1
    Albert S Koh
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Mol Pharmacol 62:921-6. 2002
    ..This is the first molecular identification of a transport mechanism by which these antidotes may enhance urinary excretion of toxic metals...
  16. ncbi Effect of sodium 2,3-dimercaptopropane-1-sulphonate (DMPS) on chronic daunorubicin toxicity in rabbits: comparison with dexrazoxane
    Radomír Hrdina
    Department of Pharmacology and Toxicology, Charles University, Prague, Faculty of Pharmacy, Hradec Kralove
    Acta Medica (Hradec Kralove) 45:99-105. 2002
    ..The underlying cause may consist in the fact that DMPS does not efficiently chelate tissue iron and thus may not prevent the formation of oxygen free radicals...
  17. ncbi Mercury toxicity and antioxidants: Part 1: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity
    Lyn Patrick
    Altern Med Rev 7:456-71. 2002
    ..This review of the literature will assess the role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity...
  18. ncbi Intravenous injection of metallic mercury: case report and course of mercury during chelation therapy with DMPS
    Birgit Vallant
    Karl Franzens University Graz, Institute of Chemistry Analytical Chemistry, Graz, Austria
    Clin Toxicol (Phila) 46:566-9. 2008
    ..Although several cases of i.v. injection of metallic mercury have been reported, it still remains an uncommon event...
  19. ncbi Metal chelators change the human sperm motility pattern
    Nicolai Wroblewski
    Center for Dermatology and Andrology, Justus Liebig University, Giessen, Germany
    Fertil Steril 79:1584-9. 2003
    ..To investigate the influence of zinc on the generation of motility...
  20. ncbi Vitamin C, glutathione, or lipoic acid did not decrease brain or kidney mercury in rats exposed to mercury vapor
    H Vasken Aposhian
    Department of Molecular and Cellular Biology, The University of Arizona, Tucson, Arizona 85721 0106, USA
    J Toxicol Clin Toxicol 41:339-47. 2003
    ..Some medical practitioners prescribe GSH and vitamin C alone or in combination with DMPS or DMSA for patients with mercury exposure that is primarily due to the mercury vapor emitted by dental amalgams...
  21. ncbi The renal Na(+)-dependent dicarboxylate transporter, NaDC-3, translocates dimethyl- and disulfhydryl-compounds and contributes to renal heavy metal detoxification
    Birgitta C Burckhardt
    Zentrum Physiologie und Pathophysiologie, Abteilung Vegetative Physiologie und Pathophysiologie, Georg August Universitat, Gottingen, Germany
    J Am Soc Nephrol 13:2628-38. 2002
    ..The data suggest that NaDC-3 is an essential component in the delivery of uncomplexed antidotes for renal heavy metal detoxification...
  22. ncbi [Fatty acid composition of lipids in erythrocytes and blood plasma in cadmium intoxication and its correction with unitiol]
    Iu I Hubs'kyĭ
    Bohomolets National Medical University, Kyiv
    Ukr Biokhim Zh 75:103-5. 2003
    ..It makes possible to assume the disturbance of both the erythrocytes membrane structure and metabolism in the erythrocyte. Unitiol injection promotes the normalisation of the indices under investigation...
  23. ncbi Stevens-Johnson syndrome in a child with chronic mercury exposure and 2,3-dimercaptopropane-1-sulfonate (DMPS) therapy
    A A A Van der Linde
    Canisius Wilhelmina Hospital, Pediatrics, Nijmegen, Netherlands
    Clin Toxicol (Phila) 46:479-81. 2008
    ..The most important step in the management of SJS is early recognition and immediate withdrawal of the causative agent. We present a patient with SJS associated with dimercaptopropane-1-sulfonate (DMPS) therapy...
  24. ncbi Interaction of the metal chelator DMPS with OAT1 and OAT3 in intact isolated rabbit renal proximal tubules
    A Lungkaphin
    Department of Physiology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Am J Physiol Renal Physiol 286:F68-76. 2004
    ..These data suggest that, whereas both OAT1 and OAT3 probably transport DMPSH, DMPSS transport may be limited to OAT3. This is the first evidence showing that both OAT1 and OAT3 can transport DMPS across the basolateral membrane of RPT...
  25. pmc Multidrug resistance proteins and the renal elimination of inorganic mercury mediated by 2,3-dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid
    Christy C Bridges
    Mercer University School of Medicine, Division of Basic Medical Sciences, 1550 College Street, Macon, GA 31207, USA
    J Pharmacol Exp Ther 324:383-90. 2008
    ..Collectively, these data support a role for Mrp2 in the DMPS- and DMSA-mediated elimination of Hg(2+) from the kidney...
  26. ncbi Effect of sodium dimercaptopropanesulfonate on antagonism of tetramethylenedisulphotetramine to GABA receptor
    C Y Zhang
    Department of Pharmacology, Wenzhou Medical College, Wenzhou 325027, China
    Acta Pharmacol Sin 22:435-9. 2001
    ..005), (0.128 +/- 0.007), and (0.125 +/- 0.008), respectively]. CONCLUSION: The inhibitory effects of DMPS on the antagonism of TETS to GABA receptor are due to the increase in the GABA binding to its receptors in brain caused by DMPS..
  27. ncbi Increase of renal excretion of organo-mercury compounds like methlymercury by DMPS (2,3-Dimercapto-1-propanesulfonic acid, Dimaval)
    Gustav Drasch
    Institute of Forensic Medicine, Ludwig Maximilians University, Munich, Germany
    Clin Toxicol (Phila) 45:266-9. 2007
    ..1 for organic Hg. There was a trend that females responded better to DMPS than males. It was concluded that DMPS increases the renal excretion of organic bound Hg as it does for inorganic Hg, but to a lesser extent...
  28. ncbi 2,3-Dimercaptopropanol, 2,3-dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid increase lead-induced inhibition of delta-aminolevulinate dehydratase in vitro and ex vivo
    F W Santos
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Av Roraima CCNE, Predio 18, CEP 97105 900, Santa Maria, RS, Brazil
    Toxicol In Vitro 20:317-23. 2006
    ..In fact, BAL and DMPS increase the inhibitory effect of lead on delta-ALA-D activity from mice blood. The complexes formed (lead and chelators) were more inhibitory than lead alone in kidney and liver enzyme activity, ex vivo...
  29. ncbi Prognos in the diagnosis of amalgam hypersensitivity a diagnostic case-control study
    Wolfgang Kohler
    Centre for Complementary Medicine Research, Department of Internal Medicine II, echnische Universität München, Germany
    Forsch Komplementmed 14:18-24. 2007
    ..We aimed to investigate whether the Prognos device might be a useful tool in the diagnosis of disorders suspected to be due to dental amalgam fillings...
  30. ncbi Cadmium inhibits delta-aminolevulinate dehydratase from rat lung in vitro: interaction with chelating and antioxidant agents
    Cristiane Luchese
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105 900, RS, Brazil
    Chem Biol Interact 165:127-37. 2007
    ..In contrast, these compounds potentiated the inhibition induced by Cd(2+) in rat lung...
  31. ncbi Dithiol compounds at low concentrations increase arsenite toxicity
    Kun Yan Jan
    Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan, ROC
    Toxicol Sci 90:432-9. 2006
    ..Therefore, the present results suggest the necessity of reevaluating the therapeutic effect of these dithiol compounds for arsenic poisoning...
  32. ncbi DMPS reverts morphologic and mitochondrial damage in OK cells exposed to toxic concentrations of HgCl2
    Pilar Carranza-Rosales
    División de Biología Celular y Molecular Centro de Investigación Biomédica del Noreste IMSS Administración de Correos No 4, Apartado Postal 020, Colonia Independencia, Monterrey, NL, CP 64720, Mexico
    Cell Biol Toxicol 23:163-76. 2007
    ..DMPS also showed potent antioxidant activity in vitro. Mitochondrial protection could be the cellular mechanism mediated by DMPS in OK cells exposed to a toxic concentration of HgCl(2)...
  33. ncbi GEA3162, a nitric oxide-releasing agent, activates non-store-operated Ca2+ entry and inhibits store-operated Ca2+ entry pathways in neutrophils through thiol oxidation
    Mei Feng Hsu
    Department of Biochemistry, School of Medicine, China Medical University, Taichung, Taiwan, Republic of China
    Eur J Pharmacol 535:43-52. 2006
    ..The dual effects of GEA3162 on the regulation of the external Ca2+ entry are mainly through the thiol modification of target protein(s) residing on the outside of the plasma membrane...
  34. ncbi Antioxidants and metallothionein levels in mercury-treated mice
    R Brandao
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, 97105 900, Santa Maria, RS, Brazil
    Cell Biol Toxicol 22:429-38. 2006
    ..Mercuric chloride poisoning caused an increase in hepatic and renal MT levels and antioxidant treatments did not modify this parameter. Our data indicated a lack of therapeutic effect of the antioxidants tested...
  35. ncbi [Mercury concentration in cerebrospinal fluid in patients with chronic mercury poisoning]
    Wei Wei Liu
    Guangzhou Prevention and Treatment Center for Occuqational Disease, Guangzhou 510620, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 24:403-5. 2006
    ..To investigate the changes of mercury (Hg) levels in cerebrospinal fluid (CSF) in patients with chronic mercury poisoning and elucidate the neurotoxic mechanism of mercury...
  36. ncbi Arsenic induced blood and brain oxidative stress and its response to some thiol chelators in rats
    Swaran J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    Life Sci 77:2324-37. 2005
    ..However, further studies are required for the choice of appropriate dose, duration of treatment and possible effects on other major organs...
  37. ncbi [Elemental mercury embolism in the lung]
    V Botnaru
    Catedra Medicină Internă nr 2, Universitatea de Stat de Medicinal si Farmacie Nicolae Testemiţanu, Chisinau, Republica Moldova
    Pneumologia 53:109-14. 2004
    ..At follow-up at 2 years, he was well, with none of the renal, gastrointestinal, or neurologic effects that can result from the oxidation of mercury. The clinical and radiological course of the patient is described...
  38. ncbi BAL modulates glutamate transport in synaptosomes and synaptic vesicles from rat brain
    C W Nogueira
    , ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Neuroreport 12:511-4. 2001
    ..The data reported here provide some evidence of glutamate involvement in BAL-induced neurotoxicity by demonstrating direct effects of BAL on glutamatergic system modulation...
  39. ncbi Analysis of time-dependent recovery from beryllium toxicity following chelation therapy and antioxidant supplementation
    Sonia Johri
    Laboratory of Toxicology and Reproductive Biology, School of Studies in Zoology, Jiwaji University, Gwalior, India
    Indian J Exp Biol 42:798-802. 2004
    ..Thus it can be concluded that DPA+Se is a better therapeutic agent as compared to DMPS+Se and GSH...
  40. ncbi Efforts to control the errant products of a targeted in vivo generator
    Jaspreet Singh Jaggi
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 65:4888-95. 2005
    ..0001). Metal chelation, diuresis with furosemide or chlorothiazide, and competitive metal blockade may be used as adjuvant therapies to modify the renal accumulation of 225Ac daughters...
  41. ncbi [Logistic regression analysis of factors influencing clinical therapeutic effect on acute tetramine poisoning]
    Li heng Wang
    Guangxi Institute of Occupational Disease, Nanning 530021, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 22:26-8. 2004
    ..To investigate the factors affecting clinical therapeutic effect on acute tetramine poisoning...
  42. ncbi Effects of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on tissue and urine mercury levels following prolonged methylmercury exposure in rats
    S D Pingree
    Department of Environmental Health, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, Washington 98105, USA
    Toxicol Sci 61:224-33. 2001
    ..In light of this observation, the inability of DMPS to reduce Hg2+ levels in brain or blood may explain the inefficacy of DMPS and similar chelating agents in the remediation of neurotoxicity associated with prolonged MMH exposure...
  43. ncbi Quantitative evaluation of urinary porphyrins as a measure of kidney mercury content and mercury body burden during prolonged methylmercury exposure in rats
    S D Pingree
    Department of Environmental Health, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, Washington 98105, USA
    Toxicol Sci 61:234-40. 2001
    ..These findings demonstrate that urinary porphyrin concentrations relate quantitatively to DMPS-mobilizable mercury in the kidney and, therefore, serve as a biochemical measure of renal mercury content...
  44. ncbi Chronic arsenic toxicity: clinical features, epidemiology, and treatment: experience in West Bengal
    D N Guha Mazumder
    Dept of Medicine and Gastroenterology, Institute of Post Graduate Medical Education and Research, Kolkata, India
    J Environ Sci Health A Tox Hazard Subst Environ Eng 38:141-63. 2003
    ..People should be advised to stop drinking As contaminated water or exposure to As from any other source. The various clinical manifestations should be treated symptomatically...
  45. ncbi [Expression of angiotensin converting enzyme and angiotensin converting enzyme 2 gene in lung of paraquat poisoning rats and protection of sodium dimercaptopropane sulfonate]
    Qiao meng Qiu
    Emergency Medical Department, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 28:275-9. 2010
    ..To investigate the expression of angiotensin converting enzyme (ACE) and ACE2 Gene in lung of paraquat poisoning rats and the protection of sodium dimercaptopropane sulfonate (Na-DMPS)...
  46. ncbi Stimulation of intracellular Ca2+ elevation in neutrophils by thiol-oxidizing phenylarsine oxide
    Jih Pyang Wang
    Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
    Biochem Pharmacol 69:1225-34. 2005
    ....
  47. pmc Arsenic accumulation by Pseudomonas stutzeri and its response to some thiol chelators
    D N Joshi
    Laboratory of Biochemistry, B R D School of Biosciences, Sardar Patel University, Vallabh Vidyanagar, 388 120, Gujarat, India
    Environ Health Prev Med 13:257-63. 2008
    ..The aim of this study is to examine arsenic accumulation by Pseudomonas stutzeri and its response to some thiol chelators, DMPS and MiADMSA...
  48. ncbi Influence of heavy metals upon the retention and mobilization of polonium-210 in rats
    J Rencova
    Centre of Occupational Health, National Institute of Public Health, Srobarova 48, 100 42 Praha, Czech Republic
    Int J Radiat Biol 80:769-76. 2004
    ....
  49. ncbi Pharmacists' role in the post-discharge management of patients with heart failure: a literature review
    A Ponniah
    School of Pharmacy and Medical Sciences, Sansom Institute, University of South Australia, Adelaide, SA, Australia
    J Clin Pharm Ther 32:343-52. 2007
    ..The aim of this literature review was to assess the role of pharmacists in the provision of post-charge services for heart failure patients...
  50. ncbi The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury
    James P K Rooney
    Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Toxicology 234:145-56. 2007
    ....
  51. ncbi The toxicity of tri-substituted benzenes to the protozoan ciliate Spirostomum ambiguum
    Grzegorz Nałgcz-Jawecki
    Department of Environmental Health Sciences, The University of Medicine, Warsaw, Poland
    Chemosphere 46:333-7. 2002
    ..The Spirotox was less sensitive than these other bioassays for the majority of these compounds, with an exception found for the dinitro derivatives...
  52. ncbi Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning
    Cristina M L Carvalho
    Research Institute for Medicines and Pharmaceutical Sciences, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal
    FASEB J 25:370-81. 2011
    ..These results stress the role of TrxR as a target of mercurials and provide the mechanism of selenite as a detoxification agent for mercury poisoning...
  53. pmc Effect of DMPS and DMSA on the placental and fetal disposition of methylmercury
    C C Bridges
    Division of Basic Medical Sciences, Mercer University School of Medicine, 1550 College Street, Macon, GA 31207, USA
    Placenta 30:800-5. 2009
    ..The results of the current study are the first to show that DMPS and DMSA are capable of extracting mercuric ions, not only from maternal tissues, but also from placental and fetal tissues following maternal exposure to CH3Hg+...
  54. ncbi [Expression of thrombomodulin, endothelial protein C receptor in lung tissue of acute paraquat poisoned rats and intervention of sodium dimercaptopropane sulfonate]
    Zhong qiu Lu
    Emergency Medical Department, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 27:453-6. 2009
    ..To observe the expression and effect of thrombomodulin (TM) mRNA and endothelial protein C receptor (EPCR) mRNA in lung tissue of acute paraquat poisoned rats, and intervention of sodium dimercaptopropane sulfonate (Na-DMPS)...
  55. ncbi Effect of sodium bicarbonate as a pharmaceutical formulation excipient on the interaction of fluvastatin with membrane phospholipids
    Germain Larocque
    Department of Chemistry, Pharmaqam NanoQAM, Universite du Quebec a Montreal, P O Box 8888, Downtown Station, Montreal, QC, H3C 3P8, Canada
    Eur Biophys J 39:1637-47. 2010
    ....
  56. ncbi Experiential learning as part of pharmacist supplementary prescribing training: feedback from trainees and their mentors
    Johnson George
    School of Pharmacy, The Robert Gordon University, Schoolhill, Aberdeen, Scotland
    Ann Pharmacother 41:1031-8. 2007
    ..During the PLP, a designated medical practitioner (DMP) supervises and supports the trainee to develop competence in prescribing...
  57. pmc Gadolinium ions block mechanosensitive channels by altering the packing and lateral pressure of anionic lipids
    Yury A Ermakov
    The Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Moscow, Russia
    Biophys J 98:1018-27. 2010
    ..This pressure can "squeeze" the channel and shift the equilibrium toward the closed state...
  58. ncbi N,N-dimethyl phytosphingosine induces caspase-8-dependent cytochrome c release and apoptosis through ROS generation in human leukemia cells
    Byeong Mo Kim
    Korea Institute of Radiological and Medical Sciences, Gongneung dong, Nowon Gu, Seoul, Republic of Korea
    Toxicol Appl Pharmacol 239:87-97. 2009
    ..Our results also suggest that ROS are critical regulators of caspase-8-mediated apoptosis in DMPS-treated leukemia cells...
  59. pmc Evaluation of a community-based inner-city disease management program for postmyocardial infarction patients: a randomized controlled trial
    Wendy Young
    Department of Health Policy, Management and Evaluation, Faculty of Medicine, University of Toronto, Toronto, Ont
    CMAJ 169:905-10. 2003
    ..Evaluations of cardiac DMPs delivered by home health nurses are required...
  60. pmc Characteristics, management and attainment of lipid target levels in diabetic and cardiac patients enrolled in Disease Management Program versus those in routine care: LUTZ registry
    Kurt Bestehorn
    Medical Department, MSD Sharp and Dohme GmbH, Haar, Germany
    BMC Public Health 9:280. 2009
    ..Little is known about the characteristics, treatment and target attainment lipid levels of these patients enrolled in DMPs compared to patients in routine care (non-DMP)...
  61. ncbi The role of glutathione on the cytotoxic effects and cellular uptake of diphenylarsinic acid, a degradation product of chemical warfare agents
    Takafumi Ochi
    Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, 199 0195 Sagamiko Kanagawa, Japan
    Arch Toxicol 80:486-91. 2006
    ..These results suggest that GSH plays a role in regulating the formation of DPA-GS and cellular uptake...
  62. ncbi Effect of four thiol-containing chelators on disposition of orally administered mercuric chloride
    J B Nielsen
    Department of Environmental Medicine, Odense University, Denmark
    Hum Exp Toxicol 10:423-30. 1991
    ....
  63. ncbi Disease management programs for depression: a systematic review and meta-analysis of randomized controlled trials
    Angela Neumeyer-Gromen
    Federal Institute for Occupational Safety and Health, 10317 Berlin, Germany
    Med Care 42:1211-21. 2004
    ..Substantial deficits in the care of depression make the provision of new evidence-based care models a matter of increasing importance. So far, disease management programs (DMPs) have not been systematically assessed...
  64. ncbi Affinity of four polar neurotransmitters for lipid bilayer membranes
    Chunhua Wang
    Research Unit for Functional Biomaterials, NSM, Roskilde University, 1 Universitetsvej, DK 4000 Roskilde, Denmark
    J Phys Chem B 115:196-203. 2011
    ..However, the strong variability in interaction strengths also shows that this attraction is not an inherent property of all neurotransmitters...
  65. ncbi Heart failure disease management program experience in 4,545 heart failure admissions to a community hospital
    Antonio Pazin-Filho
    Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Am Heart J 158:459-66. 2009
    ..Linkage to electronic records and state vital statistics enabled examination of the CHF population including individuals participating and those ineligible for the program...
  66. ncbi Chronic arsenic poisoning
    Alan H Hall
    Department of Emergency Medicine, Division of Toxicology, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA
    Toxicol Lett 128:69-72. 2002
    ..Treatment may incklude the use of chelating agents such as dimercaprol (BAL), dimercaptosuccinic acid (DMSA), and dimercaptopanesulfonic acid (DMPS)...
  67. ncbi Oxidation of proximal protein sulfhydryls by phenanthraquinone, a component of diesel exhaust particles
    Yoshito Kumagai
    Department of Environmental Medicine, Institute of Community Medicine, and Master s Program in Environmental Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Chem Res Toxicol 15:483-9. 2002
    ..From these findings, it is suggested that phenanthraquinone-mediated destruction of protein sulfhydryls appears to involve the oxidation of presumably proximal thiols and the reduction of molecular oxygen...
  68. pmc Determination of monomethylarsonous acid, a key arsenic methylation intermediate, in human urine
    X C Le
    University of Alberta, Department of Public Health Sciences, Edmonton, Alberta, Canada
    Environ Health Perspect 108:1015-8. 2000
    ..Along with the presence of MMA(III), there was an increase in the relative concentration of MMA(V) and a decrease in DMA(V) in the urine samples collected after the DMPS ingestion...
  69. ncbi [Occupational acute mercury intoxication--a case report]
    Renata Złotkowska
    Zakładu Epidemiologii, Oddziału Chorób Zawodowych, Instytutu Medycyny Pracy i Zdrowia Srodowiskowego w Sosnowcu
    Med Pr 53:315-7. 2002
    ..A control ambulatory examination (one and a half year later) did not reveal health effects of acute exposure to mercury vapors...
  70. ncbi Treatment of creosote-contaminated groundwater in a peat/sand permeable barrier--a column study
    Grete Rasmussen
    Center for Soil and Environmental Research Jordforsk, Frederik A Dahlsvei 20, 1432 Aas, Norway
    J Hazard Mater 93:285-306. 2002
    ..The results imply that a peat/sand barrier can treat creosote-contaminated groundwater. Modifications might be needed for enhanced removal of DMPs and TMPs, and oxygen supply might be necessary in aquifers with low oxygen content...
  71. ncbi The MAP kinase pathway is involved in odontoblast stimulation via p38 phosphorylation
    Stephane Simon
    Laboratoire de Physiopathologie Orale Moléculaire, INSERM, Centre de Recherche des Cordeliers, Paris, France
    J Endod 36:256-9. 2010
    ..Based on these observations, we hypothesized that p38 expression might be upregulated, and the protein activated by phosphorylation, when odontoblasts are stimulated such as during tertiary reactionary dentinogenesis...
  72. ncbi Gaseous NO2 as a regulator for ammonia oxidation of Nitrosomonas eutropha
    I Schmidt
    Institut fur Allgemeine Botanik, Abteilung Mikrobiologie, Universitat Hamburg, Germany
    Antonie Van Leeuwenhoek 79:311-8. 2001
    ..DMPS was inhibitory to nitrification under oxic conditions, while increased amounts of NO or NO2 led to increased oxidation activities...
  73. ncbi Chemical characterization of emissions from vegetable oil processing and their contribution to aerosol mass using the organic molecular markers approach
    I G Kavouras
    Environmental Chemical Processes Laboratory, Division of Environmental and Analytical Chemistry, Department of Chemistry, University of Crete, Heraclion, Greece
    J Air Waste Manag Assoc 51:552-61. 2001
    ..However, the profile of DMPs at receptor sites was similar to that observed for diesel particulates. These differences indicated that the contribution of vegetable oil processing emissions to the atmosphere was negligible...
  74. pmc Differences in the substrate binding regions of renal organic anion transporters 1 (OAT1) and 3 (OAT3)
    BETHZAIDA ASTORGA
    Dept of Pharmacology, College of Medicine, University of Arizona, Tucson, USA
    Am J Physiol Renal Physiol 301:F378-86. 2011
    ..Consistent with their homolog-specific selectivities, these data highlight structural differences in the substrate binding regions of OAT1 and OAT3...
  75. ncbi Acute mercury intoxication and use of chelating agents
    M Boscolo
    Anesthesiology, Resuscitation and Antalgic Therapy Service, Spirito Santo Hospital, Pescara, Italy
    J Biol Regul Homeost Agents 23:217-23. 2009
    ..Such agents, recommended only for the treatment of acute Hg poisoning, should not be used for patients suffering from neurological diseases in which environmental Hg exposure is hypothesised...
  76. pmc Digital music players cause interference with interrogation telemetry for pacemakers and implantable cardioverter-defibrillators without affecting device function
    Gregory Webster
    Department of Cardiology, Children s Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Heart Rhythm 5:545-50. 2008
    ..A preliminary study reported interference in 50% of patients whose devices were interrogated near Apple iPods...
  77. ncbi Effect of Mg2+ versus Ca2+ on the behavior of annexin A5 in a membrane-bound state
    Zahia Fezoua-Boubegtiten
    Laboratoire de Chimie et Biologie des Membranes et des Nano Objets, UMR CBMN, CNRS Université Bordeaux ENITAB, IECB, Pessac, France
    Eur Biophys J 40:641-9. 2011
    ..We conclude that the embedded Mg(2+) ions inside the AnxA5 structure are not able to link the protein to the phosphate group of the phospholipids for this reason...
  78. ncbi Two-year outcome of a prospective, controlled study of a disease management programme for elderly patients with heart failure
    Donatella Del Sindaco
    Division of Cardiology, Cardiogeriatric Department, INRCA Institute of Care and Research, Rome, Italy
    J Cardiovasc Med (Hagerstown) 8:324-9. 2007
    ..The aim of this study was to determine the long-term efficacy of a hybrid DMP in consecutive older outpatients...
  79. ncbi Color discrimination impairment in workers exposed to mercury vapor
    Pavel Urban
    National Institute of Public Health, Srobarova 48, 100 48 10 Prague, Czech Republic
    Neurotoxicology 24:711-6. 2003
    ..To study color discrimination impairment in workers exposed to elemental mercury (Hg) vapor...
  80. ncbi Gas chromatographic-mass spectrometric analysis of biomarkers related to folate and cobalamin status in human serum after dimercaptopropanesulfonate reduction and heptafluorobutyl chloroformate derivatization
    Petr Simek
    Biology Centre, Laboratory of Analytical Biochemistry, Academy of Sciences of the Czech Republic, Branisovska 31, CZ 370 05 Ceske Budejovice, Czech Republic
    Anal Chem 80:5776-82. 2008
    ..The results suggest that the new combined procedure of DMPS reduction and HFBCF derivatization make the method efficient for diagnostics of folate and cobalamin status as well as for screening of amino acidic metabolites in body fluids...
  81. ncbi [Metal poisoning]
    A Ferrer
    Unidad de Toxicología Clínica, Hospital Clinico Universitario, San Juan Bosco 15, 50009 Zaragoza, Spain
    An Sist Sanit Navar 26:141-53. 2003
    ..Toxicokinetic characteristics, mechanism of action, clinical picture and treatment of some of the most relevant metals and metalloids: lead, mercury and arsenic, are considered...
  82. ncbi Neurotoxicity of dental amalgam is mediated by zinc
    D Lobner
    Department of Biomedical Sciences, Marquette University, 561 N 15th Street, Rm 426, Milwaukee, WI 53201, USA
    J Dent Res 82:243-6. 2003
    ..These results indicate that amalgam is toxic to nerve cells in culture by releasing zinc. While zinc is known to be neurotoxic, ingestion of zinc is not a major concern because zinc levels in the body are tightly regulated...
  83. pmc Diazeniumdiolate reactivity in model membrane systems
    Bach T Dinh
    Department of Chemistry and Biochemistry, George Mason University, 4400 University Drive, Fairfax, VA 22030, USA
    Nitric Oxide 18:113-21. 2008
    ....
  84. ncbi Increased urinary excretion of carnitine and acylcarnitine by mercuric chloride is reversed by 2,3-dimercapto-1-propanesulfonic acid in rats
    Waleed A Al-Madani
    College of Science, King Saud University, Riyadh, Saudi Arabia
    Int J Toxicol 29:313-7. 2010
    ..However, the ratio of urinary AC:FC was significantly decreased by HgCl(2). Pretreatment with DMPS offered statistically significant protection against HgCl(2)-induced alterations in various urinary carnitine fractions in rats...
  85. ncbi The ACR Managed Care Committee: focusing private payers on radiology issues
    Christopher G Ullrich
    Charlotte Radiology PA, Charlotte, NC 28203 5823, USA
    J Am Coll Radiol 4:115-8. 2007
    ..Working together through the ACR promotes the integrity of our profession and the quality of care patients want and deserve...
  86. ncbi [Prognosis and treatment of fulminant Wilson's disease]
    Yi Tian
    Center for Liver Disease Research, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 36:1111-4. 2011
    ..To explore the effective treatment and prognostic factors for fulminant Wilson's disease (FWD)...
  87. ncbi [Results of a survey of insurance customers participating in a DMP for diabetes mellitus type 2 of BARMER Health Insurance, Neubrandenburg]
    T Elkeles
    Hochschule Neubrandenburg, Fachbereich Gesundheit und Pflege, Neubrandenburg, Germany
    Gesundheitswesen 69:18-25. 2007
    ..In future, quality assurance studies should be carried out in order to validate surveys addressing participants in DMPs and, conversely, surveys of DMP participants should be conducted to validate quality assurance findings...
  88. ncbi Case study: targeted high-throughput sequencing of mitochondrial genomes from extinct cave bears via direct multiplex PCR sequencing (DMPS)
    Mathias Stiller
    Department of Biology, The Pennsylvania State University, 320 Mueller Laboratory, University Park, PA 16802, USA
    Methods Mol Biol 840:171-6. 2012
    ..In this chapter, I describe an experiment that uses DMPS with different primer sets and on both modern and ancient DNA templates...
  89. ncbi Influence of glutathione chemical effectors in the response of maize to arsenic exposure
    Raquel Requejo
    Department of Biochemistry and Molecular Biology, ETSIAM, University of Cordoba, Campus de Rabanales, Edificio Severo Ochoa, Ctra N IVa Km 396, 14071 Cordoba, Spain
    J Plant Physiol 169:649-56. 2012
    ..5- and 4.0-fold by DMS and DMPS. Therefore, tolerance and accumulation of arsenic by maize could be manipulated pharmacologically by chemical effectors of GSH...
  90. ncbi Views of pharmacists and mentors on experiential learning for pharmacist supplementary prescribing trainees
    Johnson George
    School of Pharmacy, The Robert Gordon University, Schoolhill, Aberdeen, Scotland, UK
    Pharm World Sci 30:265-71. 2008
    ..To explore the views and experiences of pharmacists and their mentoring designated medical practitioners (DMPs) about the 'period of learning in practice' (PLP) as part of supplementary prescribing (SP) training...
  91. ncbi Effect of salt on the interaction of Hal18 with lipid membranes
    Sarah R Dennison
    School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, UK
    Eur Biophys J 41:769-76. 2012
    ..This concept is supported by lysis data. Overall, it would appear that this peptide is a potential candidate for future AMP design for use in high salt environments...
  92. ncbi Enhancement of TLR-mediated innate immune responses by peptidoglycans through NOD signaling
    H Takada
    Department of Microbiology and Immunology, Tohoku University Graduate School of Dentistry, Aoba ku, Sendai, Japan
    Curr Pharm Des 12:4163-72. 2006
    ..Considering these findings altogether, in host-bacteria interactions, host cells should recognize bacteria via both TLRs and NODs, which might induce synergistic innate and adaptive immune responses...
  93. ncbi Preferences of Japanese rheumatoid arthritis patients in treatment decision-making
    Akiko Aoki
    Department of General Medicine, Tokyo Medical University Hachioji Medical Center, Tatemachi 1163, Hachioji, Tokyo, 193 0998, Japan
    Mod Rheumatol 23:891-6. 2013
    ..In addition, we evaluated the factors associated with patients' preferences for decision-making...
  94. ncbi Toward tailored disease management for type 2 diabetes
    Arianne M J Elissen
    Department of Health Services Research, CAPHRI School for Public Health and Primary Care, Maastricht University, The Netherlands
    Am J Manag Care 18:619-30. 2012
    ..To assess the differentiated effects of population-based disease management programs (DMPs) for type 2 diabetes on intermediary clinical outcomes in The Netherlands...
  95. ncbi [Long-term follow-up after intravenous injection of mercury--two cases report]
    Halina Goszcz
    Oddział Toksykologii i Chorób Wewnetrznych, Szpitala Specjalistycznego im Ludwika Rydygiera w Krakowie
    Przegl Lek 69:580-4. 2012
    ..Mercury depots in the lung are still present. The blood and urine mercury concentration is low (13.7 microg/L and 2.53 microg/L). In mean time she gave birth two healthy children. Further patients evaluation is necessary...
  96. pmc The role of chelation in the treatment of arsenic and mercury poisoning
    Michael J Kosnett
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University of Colorado School of Medicine, 1630 Welton, Suite 300, Denver, CO, 80202, USA
    J Med Toxicol 9:347-54. 2013
    ..DMPS (unithiol) and DMSA (succimer), dithiol water-soluble analogs of BAL, were developed in the Soviet Union and China in the ..
  97. ncbi Minimal-change nephrotic syndrome due to occupational mercury vapor inhalation
    G Campbell
    Departments of Nephrology, St James University Hospital, Leeds, London, UK
    Clin Nephrol 72:216-9. 2009
    ..He remains well with normal renal function, blood pressure and normal blood and urine mercury concentrations...
  98. ncbi Quality of diabetes care in Austrian diabetic patients willing to participate in a DMP - at baseline
    Maria Flamm
    Institute of General Practice, Family Medicine and Preventive Medicine, Paracelsus Medical University, Salzburg, Austria
    Wien Klin Wochenschr 123:436-43. 2011
    ..We therefore investigated the baseline characteristics of patients willing to enrol in the Austrian DMP for diabetes mellitus type 2 ("Therapie aktiv"), and their quality of care...
  99. ncbi Use of structure-controlled polymers as high performance powder dispersants in the silicone oil phase
    Ayano Nakamura
    Shiseido Research Center, Tsuzuki ku, Yokohama, Japan
    J Oleo Sci 56:245-51. 2007
    ..These results mean that such a tri-block copolymer would make it possible to develop consumer demanded sunscreens...
  100. ncbi Quantification and identification of mitochondrial proteins containing vicinal dithiols
    Raquel Requejo
    MRC Mitochondrial Biology Unit, Cambridge, UK
    Arch Biochem Biophys 504:228-35. 2010
    ..These findings are consistent with roles for mitochondrial vicinal dithiol proteins in antioxidant defence and redox signalling and these methodologies will enable these roles to be explored...

Research Grants23

  1. Dense Medium Plasma Remediation of VOCs in Groundwater
    Yonghui Ma; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  2. RENAL TRANSPORT OF ORGANIC CHELATORS OF HEAVY METALS
    Stephen Wright; Fiscal Year: 2004
    ..The proposed studies will result in a new, general model of the cellular strategy for secretion of a diverse array of xenobiotic OAs, and a more specific understanding of the action of heavy metal chelators on renal cells. ..
  3. Leptin Control of Obesity
    Mary Clark; Fiscal Year: 2005
    ..These parameters were collected prior to, and at 3 monthly intervals during the 2-year study in 323 women either on DMPA or control. ..
  4. MERCURY NEPHROTOXICITY AFTER A REDUCTION OF RENAL MASS
    RUDOLFS ZALUPS; Fiscal Year: 2002
    ..abstract_text> ..
  5. TRANSPORT AND TOXICITY OF MERCURY IN THE NEPHRON
    RUDOLFS ZALUPS; Fiscal Year: 2006
    ..to date, of the mechanisms involved in the uptake of inorganic mercuric ions along pars recta segments of the proximal tubule, which are the segments of the nephron most vulnerable to the nephrotoxic effects of mercury ..
  6. METALLOTHIONEIN, MERCURY AND MONOCYTE ACTIVATION
    RUDOLFS ZALUPS; Fiscal Year: 2006
    ....
  7. MECHANISMS FOR RENAL UPTAKE OF MERCURY
    CHRISTY BRIDGES; Fiscal Year: 2005
    ..These studies are important in that they will determine the exact mechanisms that participate in the transport of mercury across the plasma membranes of the proximal tubular cells. ..
  8. Role of Multidrug Resistance Proteins 2 and/or 4, and DMPS and DMSA in the Renal
    CHRISTY BRIDGES; Fiscal Year: 2008
    ..These data will serve as the basis for the development of additional treatments for mercury poisoning. [unreadable] [unreadable] [unreadable] [unreadable]..
  9. 2D Nano-flow Mass Spectrometry System
    ELIZABETH KOMIVES; Fiscal Year: 2006
    ..Hook and D. T. O'Connor will analyze the biosynthesis of bioactive peptides. Professor R. Tsien will explore the possibilities of using ReAsH reagents to discover proteins in close proximity in the cell. [unreadable] [unreadable]..
  10. BIOPHYSICAL STUDIES OF LRP LIGANDS INTERACTIONS
    ELIZABETH KOMIVES; Fiscal Year: 2003
    ..In particular, we will probe the role of hepara sulfate proteoglycans in the reaction. (5) Determine the structures of minimal fragments of LRP ligands bound to minimal fragments of the LRP extracellular domain. ..
  11. Growth factor effects on dental pulp cells
    DOUGLAS LOBNER; Fiscal Year: 2008
    ..As a method of maintaining the viability of these cells we are proposing studying the effects of naturally occurring substances called growth factors on dental pulp cells. [unreadable] [unreadable] [unreadable]..
  12. Acquisition of an MALDI TOF-TOF Mass Spectrometer
    ELIZABETH KOMIVES; Fiscal Year: 2005
    ..For this project, the MALDI-TOF-TOF will enable measurements of amide deuteration down to the single amino acid level. ..
  13. Morphine versus Methadone as First Line Strong Opioid for Cancer Pain
    Eduardo Bruera; Fiscal Year: 2009
    ..Relevance to Public Health: In this study, we will test if methadone is better than morphine in cancer pain control, quality of life, and is more cost-effective. ..
  14. Methylphenidate for Fatigue in Advanced Cancer Patients
    Eduardo Bruera; Fiscal Year: 2009
    ....
  15. Directed Proteomics of Alzheimer's Related Proteins
    ELIZABETH KOMIVES; Fiscal Year: 2008
    ..4) Quantitative proteomics (ICAT) will be applied to age-correlated, AD and healthy brain lysates to develop a correlation between amounts of APP and LRP 1-protein interaction complexes and Abeta production. ..
  16. Parenteral Hydration in Advanced Cancer Patients: A Randomized Controlled Trial
    Eduardo Bruera; Fiscal Year: 2009
    ..In this study, we will test if giving fluid through the vein will improve the symptoms, delay confusion and prolong life in patients who are no longer to drink at the end of life. ..
  17. Technology for DNA Damage Analysis and Biomarkers
    X Le; Fiscal Year: 2004
    ..The technology will also be useful for monitoring DNA damage induced by anticancer agents and for studying DNA repair, which is an essential protection mechanism against cancer initiation. ..
  18. MECHANISMS OF INJURY POTENTIATION BY GROWTH FACTORS
    DOUGLAS LOBNER; Fiscal Year: 2004
    ..It is believed that these studies will aid in determining under what conditions growth factor induced potentiation of cell death may be of concern regarding their therapeutic use, and how those concerns may be addressed. ..
  19. Structure and Activation of Protein Kinase C Enzymes
    JULIANNE SANDO; Fiscal Year: 2006
    ..If time permits, examination of additional isozymes will be initiated. ..
  20. MOLECULAR TOXICOLOGY IN HUMAN KIDNEY CELLS
    Lawrence Lash; Fiscal Year: 2007
    ..Achievement of these aims should build on our previous work in human kidney cells and extend it to provide a much more complete understanding of the various and complex ways in which DCVC affects the human kidney [unreadable] [unreadable]..
  21. GLUTATHIONE AND MITOCHONDRIA IN TOXIC RENAL INJURY
    Lawrence Lash; Fiscal Year: 2003
    ..This information may have therapeutic applications for prevention of renal cellular injury or for understanding mitochondrial diseases or age-related decreases that occur in mitochondrial function. ..