sulfhydryl compounds

Summary

Summary: Compounds containing the -SH radical.

Top Publications

  1. ncbi Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
    F Q Schafer
    Free Radical Research Institute and ESR Facility, The University of Iowa, Iowa City, IA 52242 1101, USA
    Free Radic Biol Med 30:1191-212. 2001
  2. ncbi Protein S-nitrosylation: purview and parameters
    Douglas T Hess
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Mol Cell Biol 6:150-66. 2005
  3. ncbi Thiol chemistry and specificity in redox signaling
    Christine C Winterbourn
    Free Radical Research Group and the National Research Centre for Growth and Development, Department of Pathology, University of Otago, Christchurch, New Zealand
    Free Radic Biol Med 45:549-61. 2008
  4. ncbi Elaboration and characterization of thiolated chitosan-coated acrylic nanoparticles
    Irene Bravo-Osuna
    Laboratoire de Physicochimie, Pharmacotechnie et Biopharmacie, , , 5, , 92296 Chatenay Malabry, France
    Int J Pharm 316:170-5. 2006
  5. ncbi Palladacycles catalyse the oxidation of critical thiols of the mitochondrial membrane proteins and lead to mitochondrial permeabilization and cytochrome c release associated with apoptosis
    Debora P Santana
    Centro Interdisciplinar de Investigação Bioquímica CIIB, Universidade de Mogi das Cruzes UMC, Av Dr Cândido Xavier de Almeida e Souza, 200 Mogi das Cruzes, Sao Paulo, Brazil
    Biochem J 417:247-56. 2009
  6. ncbi S-glutathionylation in protein redox regulation
    Isabella Dalle-Donne
    Department of Biology, University of Milan, I 20133 Milan, Italy
    Free Radic Biol Med 43:883-98. 2007
  7. ncbi Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule
    Amy Trott
    Department of Microbiology and Molecular Genetics, University of Texas Medical School, Houston, TX 77030, USA
    Mol Biol Cell 19:1104-12. 2008
  8. ncbi Nitric oxide activates TRP channels by cysteine S-nitrosylation
    Takashi Yoshida
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615 8510, Japan
    Nat Chem Biol 2:596-607. 2006
  9. ncbi The high reactivity of peroxiredoxin 2 with H(2)O(2) is not reflected in its reaction with other oxidants and thiol reagents
    Alexander V Peskin
    Free Radical Research Group, Department of Pathology, University of Otago, P O Box 4345, Christchurch, New Zealand
    J Biol Chem 282:11885-92. 2007
  10. ncbi Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport
    Eric J Niesor
    Pharmaceuticals Division, F Hoffmann La Roche Ltd, Basel, Switzerland
    J Lipid Res 51:3443-54. 2010

Research Grants

  1. CHEMICAL SYNTESIS OF BETA MANNO- AND RHAMNOPYRANOSIDES
    David Crich; Fiscal Year: 2001
  2. A metabolomic model of aging in the common marmoset
    DANIEL EDWARD LEE PROMISLOW; Fiscal Year: 2010
  3. Methods and Mechanisms in Carbohydrate Chemistry
    David Crich; Fiscal Year: 2003
  4. Methods and Mechanisms in Carbohydrate Chemistry
    David Crich; Fiscal Year: 2007
  5. Nuclear and Cytoplasmic Redox in Oxidative Stress
    Dean Jones; Fiscal Year: 2007
  6. Chemical Synthesis of Beta-Manno and Rehamnopyranosides
    David Crich; Fiscal Year: 2007
  7. Nuclear and Cytoplasmic Redox in Oxidative Stress
    Dean Jones; Fiscal Year: 2009
  8. Thioredoxin-2 protection against mitochondrial oxidative toxicity
    Dean P Jones; Fiscal Year: 2010
  9. Nuclear and Cytoplasmic Redox in Oxidative Stress
    Dean P Jones; Fiscal Year: 2010
  10. MITOCHONDRIA IN CHEMICAL-INDUCED APOPTOSIS
    Dean Jones; Fiscal Year: 2007

Detail Information

Publications225 found, 100 shown here

  1. ncbi Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
    F Q Schafer
    Free Radical Research Institute and ESR Facility, The University of Iowa, Iowa City, IA 52242 1101, USA
    Free Radic Biol Med 30:1191-212. 2001
    ..These are the first steps toward a new quantitative biology, which hopefully will provide a rationale and understanding of the cellular mechanisms associated with cell growth and development, signaling, and reductive or oxidative stress...
  2. ncbi Protein S-nitrosylation: purview and parameters
    Douglas T Hess
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Mol Cell Biol 6:150-66. 2005
    ..S-nitrosylation thereby conveys a large part of the ubiquitous influence of nitric oxide (NO) on cellular signal transduction, and provides a mechanism for redox-based physiological regulation...
  3. ncbi Thiol chemistry and specificity in redox signaling
    Christine C Winterbourn
    Free Radical Research Group and the National Research Centre for Growth and Development, Department of Pathology, University of Otago, Christchurch, New Zealand
    Free Radic Biol Med 45:549-61. 2008
    ..We discuss areas where observations in cell systems can be rationalized with the reactivity of specific oxidants and where further work is needed to understand the mechanisms involved...
  4. ncbi Elaboration and characterization of thiolated chitosan-coated acrylic nanoparticles
    Irene Bravo-Osuna
    Laboratoire de Physicochimie, Pharmacotechnie et Biopharmacie, , , 5, , 92296 Chatenay Malabry, France
    Int J Pharm 316:170-5. 2006
    ..This new system, combining both the advantages of thiolated polymers and colloidal particles can be proposed as an original drug carrier system for mucosal delivery of biotechnology products...
  5. ncbi Palladacycles catalyse the oxidation of critical thiols of the mitochondrial membrane proteins and lead to mitochondrial permeabilization and cytochrome c release associated with apoptosis
    Debora P Santana
    Centro Interdisciplinar de Investigação Bioquímica CIIB, Universidade de Mogi das Cruzes UMC, Av Dr Cândido Xavier de Almeida e Souza, 200 Mogi das Cruzes, Sao Paulo, Brazil
    Biochem J 417:247-56. 2009
    ..Besides the contribution to clarify the pro-apoptotic mechanism of PdC, this study shows that the catalysis of specific protein thiol cross-linkage is enough to induce mitochondrial permeabilization and cytochrome c release...
  6. ncbi S-glutathionylation in protein redox regulation
    Isabella Dalle-Donne
    Department of Biology, University of Milan, I 20133 Milan, Italy
    Free Radic Biol Med 43:883-98. 2007
    ..In this review, we describe recent breakthroughs in our understanding of the potential role of protein S-glutathionylation in the redox regulation of signal transduction...
  7. ncbi Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule
    Amy Trott
    Department of Microbiology and Molecular Genetics, University of Texas Medical School, Houston, TX 77030, USA
    Mol Biol Cell 19:1104-12. 2008
    ....
  8. ncbi Nitric oxide activates TRP channels by cysteine S-nitrosylation
    Takashi Yoshida
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615 8510, Japan
    Nat Chem Biol 2:596-607. 2006
    ..These findings reveal the structural motif for the NO-sensitive activation gate in TRP channels and indicate that NO sensors are a new functional category of cellular receptors extending over different TRP families...
  9. ncbi The high reactivity of peroxiredoxin 2 with H(2)O(2) is not reflected in its reaction with other oxidants and thiol reagents
    Alexander V Peskin
    Free Radical Research Group, Department of Pathology, University of Otago, P O Box 4345, Christchurch, New Zealand
    J Biol Chem 282:11885-92. 2007
    ..These results demonstrate that peroxiredoxin 2 has a tertiary structure that facilitates reaction of the active site thiol with hydrogen peroxide while restricting its reactivity with other thiol reagents...
  10. ncbi Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport
    Eric J Niesor
    Pharmaceuticals Division, F Hoffmann La Roche Ltd, Basel, Switzerland
    J Lipid Res 51:3443-54. 2010
    ..These data suggest that modulation of CETP activity by dalcetrapib does not inhibit CETP-induced pre-β-HDL formation, which may be required to increase reverse cholesterol transport...
  11. ncbi Drevogenin D prevents selenite-induced oxidative stress and calpain activation in cultured rat lens
    P G Biju
    Department of Biochemistry, University of Kerala, Kerala, India
    Mol Vis 13:1121-9. 2007
    ..The purpose of the study was to evaluate the role of Drevogenin D, a triterpenoid aglycone, isolated from Dregea volubilis in preventing selenite-induced, calcium-activated, calpain-mediated proteolysis in cultured rat lenses...
  12. ncbi Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial
    Zahi A Fayad
    Translational and Molecular Imaging Institute and Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Lancet 378:1547-59. 2011
    ..dal-PLAQUE is the first multicentre study using novel non-invasive multimodality imaging to assess structural and inflammatory indices of atherosclerosis as primary endpoints...
  13. ncbi Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
    A T Dinkova-Kostova
    Department of Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:3404-9. 2001
    ..This enhancement correlates with more rapid reactivity of the ortho-hydroxylated derivatives with model sulfhydryl compounds. Proton NMR spectroscopy provides no evidence for increased electrophilicity of the beta-vinyl carbons (the ..
  14. ncbi Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage
    Raquel Requejo
    MRC Mitochondrial Biology Unit, Wellcome Trust MRC Building, Cambridge, UK
    FEBS J 277:1465-80. 2010
    ..Therefore, exposed protein thiols are the dominant free thiol within the cell and may play a critical role in intracellular antioxidant defences against oxidative damage...
  15. ncbi OxyR: a molecular code for redox-related signaling
    Sung Oog Kim
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 109:383-96. 2002
    ....
  16. ncbi Cystic fibrosis transmembrane conductance regulator: using differential reactivity toward channel-permeant and channel-impermeant thiol-reactive probes to test a molecular model for the pore
    Christopher Alexander
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Biochemistry 48:10078-88. 2009
    ..The results provide an initial validation of two, new molecular models for CFTR and suggest that molecular dynamics simulation will be a useful tool for unraveling the structural basis of anion conduction by CFTR...
  17. ncbi A sensitive method for the quantitative measurement of protein thiol modification in response to oxidative stress
    Aimee Landar
    Department of Pathology, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Free Radic Biol Med 40:459-68. 2006
    ..Thus, we have developed a versatile, cost-effective standard that can be used in proteomic methods to quantitate biotin tags in response to oxidative stress...
  18. ncbi Cell-surface thiols affect cell entry of disulfide-conjugated peptides
    Soline Aubry
    UPMC Universite Paris 06, UMR 7613, Synthesis, Structure, and Function of Bioactive Molecules, Paris, France
    FASEB J 23:2956-67. 2009
    ....
  19. ncbi Tuning of shell and core characteristics of chitosan-decorated acrylic nanoparticles
    I Bravo-Osuna
    CNRS, UMR CNRS 8612, Faculte de Pharmacie, 5 rue J B Clement, 92296 Chatenay Malabry, France
    Eur J Pharm Sci 30:143-54. 2007
    ..Positive surface charge values were obtained in all cases. In addition, evidences of the presence of thiol groups were obtained (0.03-0.16 x 10(-3)micromol/cm(2) of nanoparticle)...
  20. ncbi A bystander effect observed in boron neutron capture therapy: a study of the induction of mutations in the HPRT locus
    Yuko Kinashi
    Research Reactor Institute, Kyoto University, Osaka, Japan
    Int J Radiat Oncol Biol Phys 68:508-14. 2007
    ..The BSH-containing cells were irradiated with alpha-particles produced by the 10B(n,alpha)7Li reaction, whereas cells without boron were affected only by the 1H(n,gamma)2H and 14N(n,rho)14C reactions...
  21. ncbi Monofunctional gold nanoparticles prepared via a noncovalent-interaction-based solid-phase modification approach
    Xiong Liu
    Nanoscience Technology Center and Department of Chemistry, University of Central Florida, 12424 Research Parkway Suit 400, Orlando, FL 32826, USA
    Small 2:1126-9. 2006
  22. ncbi Evidence that the heme regulatory motifs in heme oxygenase-2 serve as a thiol/disulfide redox switch regulating heme binding
    Li Yi
    Department of Biochemistry, University of Nebraska, Lincoln, Nebraska 68588 0664, USA
    J Biol Chem 282:21056-67. 2007
    ....
  23. ncbi Pink-eyed dilution protein modulates arsenic sensitivity and intracellular glutathione metabolism
    Liliana Staleva
    The Ronald O Perelman Department of Dermatology, New York University School of Medicine, New York, New York 10016, USA
    Mol Biol Cell 13:4206-20. 2002
    ..Our data demonstrate that the pink-eyed dilution protein increases cellular sensitivity to arsenicals and other metalloids and can modulate intracellular glutathione metabolism...
  24. ncbi Mucoadhesive thiolated chitosans as platforms for oral controlled drug delivery: synthesis and in vitro evaluation
    Marta Roldo
    Institute of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Vienna, Austria
    Eur J Pharm Biopharm 57:115-21. 2004
    ..These results contribute to the development of new delivery systems exhibiting improved mucoadhesive properties...
  25. ncbi Isotope-coded affinity tag (ICAT) approach to redox proteomics: identification and quantitation of oxidant-sensitive cysteine thiols in complex protein mixtures
    Mahadevan Sethuraman
    Vascular Biology Unit, Cardiovascular Proteomics Center, and Mass Spectrometry Resource, Boston University School of Medicine, Boston, MA 02118, USA
    J Proteome Res 3:1228-33. 2004
    ....
  26. ncbi Thiol-disulfide balance: from the concept of oxidative stress to that of redox regulation
    Pietro Ghezzi
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Antioxid Redox Signal 7:964-72. 2005
    ..This review discusses the importance of protein oxidation in redox regulation in view of the recent data originating from the application of redox proteomics to identify redox-sensitive targets...
  27. ncbi Molecular mechanisms and potential clinical significance of S-glutathionylation
    Isabella Dalle-Donne
    Department of Biology, University of Milan, Milan, Italy
    Antioxid Redox Signal 10:445-73. 2008
    ..Recently, specific PSSG have been identified in the inferior parietal lobule in Alzheimer's disease. However, much investigation is needed to clarify the actual involvement of protein S-glutathionylation in many human diseases...
  28. ncbi Protein thiol modifications visualized in vivo
    Lars I Leichert
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA
    PLoS Biol 2:e333. 2004
    ..Remarkably, a number of these proteins were previously or are now shown to be redox regulated...
  29. ncbi Thiolated polymers--thiomers: development and in vitro evaluation of chitosan-thioglycolic acid conjugates
    C E Kast
    Institute of Pharmaceutical Technology and Biopharmaceutics, Center of Pharmacy, University of Vienna, Austria
    Biomaterials 22:2345-52. 2001
    ..According to these results. chitosan-TGA conjugates represent a promising tool for the development of mucoadhesive drug delivery systems...
  30. ncbi Dalcetrapib: no off-target toxicity on blood pressure or on genes related to the renin-angiotensin-aldosterone system in rats
    E S G Stroes
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Br J Pharmacol 158:1763-70. 2009
    ..The effects of dalcetrapib (RO4607381/JTT-705) and torcetrapib on haemodynamics and the renin-angiotensin-aldosterone system (RAAS) were therefore assessed in a rat model...
  31. ncbi Mechanistic and kinetic details of catalysis of thiol-disulfide exchange by glutaredoxins and potential mechanisms of regulation
    MOLLY M GALLOGLY
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    Antioxid Redox Signal 11:1059-81. 2009
    ..Part II presents potential mechanisms for in vivo regulation of Grx activity, providing avenues for future studies...
  32. ncbi Transcriptional regulation via cysteine thiol modification: a novel molecular strategy for chemoprevention and cytoprotection
    Hye-Kyung Na
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul, South Korea
    Mol Carcinog 45:368-80. 2006
    ....
  33. ncbi 5,6-Dihydrocyclopenta[c][1,2]-dithiole-3(4H)-thione is a promising cancer chemopreventive agent in the urinary bladder
    Joseph D Paonessa
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Chem Biol Interact 180:119-26. 2009
    ..In conclusion, CPDT potently and preferentially induces Phase 2 enzymes in the bladder epithelium and Nrf2 is its key mediator...
  34. ncbi Oxidative stress in cataractogenesis
    Sonja Cekic
    Eye Clinic, Clinic Centre Nis, Bulevar dr Zorana Đinđića 48, 18000 Nis, Serbia
    Bosn J Basic Med Sci 10:265-9. 2010
    ....
  35. ncbi Anacetrapib and dalcetrapib: two novel cholesteryl ester transfer protein inhibitors
    Marta A Miyares
    Pharmacy Department, Jackson Memorial Hospital, Miami, FL, USA
    Ann Pharmacother 45:84-94. 2011
    ....
  36. ncbi Identification of an unintended consequence of Nrf2-directed cytoprotection against a key tobacco carcinogen plus a counteracting chemopreventive intervention
    Joseph D Paonessa
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 71:3904-11. 2011
    ..Thus, CPDT exemplifies a counteracting solution to the dilemma posed by Nrf2...
  37. ncbi A novel role for cytochrome c: Efficient catalysis of S-nitrosothiol formation
    Swati Basu
    Department of Physics, Wake Forest University, Winston Salem, NC 27109, USA
    Free Radic Biol Med 48:255-63. 2010
    ....
  38. ncbi GEA3162, a nitric oxide-releasing agent, activates non-store-operated Ca2+ entry and inhibits store-operated Ca2+ entry pathways in neutrophils through thiol oxidation
    Mei-Feng Hsu
    Department of Biochemistry, School of Medicine, China Medical University, Taichung, Taiwan, Republic of China
    Eur J Pharmacol 535:43-52. 2006
    ..The dual effects of GEA3162 on the regulation of the external Ca2+ entry are mainly through the thiol modification of target protein(s) residing on the outside of the plasma membrane...
  39. ncbi Kinetic and thermodynamic aspects of cellular thiol-disulfide redox regulation
    Kristine Steen Jensen
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Antioxid Redox Signal 11:1047-58. 2009
    ..This is accomplished by enzymes, such as the oxidoreductases, that direct reactions in thermodynamically favorable directions by decreasing the activation energy barrier...
  40. ncbi Cysteinylation and homocysteinylation of plasma protein thiols during ageing of healthy human beings
    R Rossi
    Department of Evolutionary Biology, University of Siena, Siena, Italy
    J Cell Mol Med 13:3131-40. 2009
    ..The drop in the plasma level of protein sulphydryl groups suggests depletion and/or impairment of the antioxidant capacity of plasma, likely related to an alteration of the delicate balance between the different redox forms of thiols...
  41. ncbi Bound homocysteine, cysteine, and cysteinylglycine distribution between albumin and globulins
    Glen L Hortin
    Department of Laboratory Medicine, Warren Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Chem 52:2258-64. 2006
    ..Major portions of homocysteine (Hcy), cysteine (Cys), cysteinylglycine (CysGly), and glutathione in serum are covalently bound to proteins via disulfides. Albumin has been considered the dominant binding protein...
  42. ncbi Age-related influence on thiol, disulfide, and protein-mixed disulfide levels in human plasma
    Daniela Giustarini
    Department of Neuroscience, Pharmacology Unit, University of Siena, Via A Moro 4, I 53100, Siena, Italy
    J Gerontol A Biol Sci Med Sci 61:1030-8. 2006
    ..The occurrence of two distinct regulatory systems for plasmatic pools of glutathione/cysteinylglycine on the one hand and cysteine/homocysteine on the other hand is hypothesized...
  43. ncbi The cataract-associated R14C mutant of human gamma D-crystallin shows a variety of intermolecular disulfide cross-links: a Raman spectroscopic study
    Ajay Pande
    Department of Chemistry, Life Sciences Research Building, University at Albany, State University of New York, Albany, New York 12222, USA
    Biochemistry 48:4937-45. 2009
    ....
  44. ncbi The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability
    M Conrad
    Institute of Clinical Molecular Biology and Tumour Genetics, GSF Research Centre for Environment and Health, Munich, Germany
    Mol Cell Biol 25:7637-44. 2005
    ..We conclude that nPHGPx, by acting as a protein thiol peroxidase in vivo, contributes to the structural stability of sperm chromatin...
  45. ncbi Quantification of oxidative posttranslational modifications of cysteine thiols of p21ras associated with redox modulation of activity using isotope-coded affinity tags and mass spectrometry
    Mahadevan Sethuraman
    Vascular Biology Unit, Boston University School of Medicine, Boston, MA 02118, USA
    Free Radic Biol Med 42:823-9. 2007
    ..The quantitative changes in thiol modification caused by GSSG associated with increased activity demonstrate the potential importance of redox modulation of p21ras...
  46. ncbi The potential of transferrin-pendant-type polyethyleneglycol liposomes encapsulating decahydrodecaborate-(10)B (GB-10) as (10)B-carriers for boron neutron capture therapy
    Shin Ichiro Masunaga
    Particle Radiation Oncology Research Laboratory, Kyoto University, Kumatori, Osaka, Japan
    Int J Radiat Oncol Biol Phys 66:1515-22. 2006
    ..To evaluate GB-10-encapsulating transferrin (TF)-pendant-type polyethyleneglycol (PEG) liposomes as tumor-targeting (10)B-carriers for boron neutron capture therapy...
  47. ncbi Quantification and identification of mitochondrial proteins containing vicinal dithiols
    Raquel Requejo
    MRC Mitochondrial Biology Unit, Cambridge, UK
    Arch Biochem Biophys 504:228-35. 2010
    ..These findings are consistent with roles for mitochondrial vicinal dithiol proteins in antioxidant defence and redox signalling and these methodologies will enable these roles to be explored...
  48. ncbi Effect of different mouthrinses on morning breath
    D van Steenberghe
    Department of Periodontology, Oral Pathology and Maxillo-Facial Surgery, Faculty of Medicine, Catholic University of Leuven, Belgium
    J Periodontol 72:1183-91. 2001
    ..CHX-Alc and CHX-CPC-Zn mouthrinses result in a significant reduction of the microbial load of tongue and saliva...
  49. ncbi Measuring mitochondrial protein thiol redox state
    Raquel Requejo
    Medical Research Council Mitochondrial Biology Unit, Wellcome Trust MRC Building, Cambridge, UK
    Methods Enzymol 474:123-47. 2010
    ..Here we outline some of the approaches that can be used to accomplish these goals and thereby infer the multiple roles of mammalian mitochondrial protein thiols in antioxidant defense and redox signaling...
  50. ncbi Quantifying changes in the thiol redox proteome upon oxidative stress in vivo
    Lars I Leichert
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 North University, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 105:8197-202. 2008
    ..These experiments illustrate that OxICAT, which can be used in a variety of different cell types and organisms, is a powerful tool to identify, quantify, and monitor oxidative thiol modifications in vivo...
  51. ncbi Thiol-disulfide exchange in an immunoglobulin-like fold: structure of the N-terminal domain of DsbD
    Celia W Goulding
    Howard Hughes Medical Institute and Laboratory of Structural Biology and Molecular Medicine, UCLA DOE, P O Box 951570, Los Angeles, California 90095 1570, USA
    Biochemistry 41:6920-7. 2002
    ..A model is discussed whereby the immunoglobulin fold of DsbD(N) may provide for the discriminating interaction with thioredoxin-like factors, thereby triggering movement of the phenylalanine cap followed by disulfide rearrangement...
  52. ncbi Tumor-specific targeting of sodium borocaptate (BSH) to malignant glioma by transferrin-PEG liposomes: a modality for boron neutron capture therapy
    Atsushi Doi
    Department of Neurosurgery, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka 569 8686, Japan
    J Neurooncol 87:287-94. 2008
    ..To improve a drug delivery in BNCT, we devised transferrin-conjugated polyethylene-glycol liposome encapsulating sodium borocaptate (TF-PEG-BSH)...
  53. ncbi Positive and negative feedback regulatory loops of thiol-oxidative stress response mediated by an unstable isoform of sigmaR in actinomycetes
    Min Sik Kim
    Laboratory of Molecular Microbiology, School of Biological Sciences and Institute of Microbiology, Seoul National University, Seoul, Korea
    Mol Microbiol 73:815-25. 2009
    ..We observed that sigH gene, the sigR orthologue in Mycobacterium smegmatis, produces an unstable larger isoform of sigma(H) upon induction by thiol-oxidative stress...
  54. ncbi Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling
    Sue Goo Rhee
    Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 38:1543-52. 2005
    ..This reversible overoxidation may represent an adaptation unique to eukaryotic cells that accommodates the intracellular messenger function of H(2)O(2), but experimental validation of such speculation is yet to come...
  55. ncbi Mucosal sulfhydryl compounds evaluation by in vivo electron spin resonance spectroscopy in mice with experimental colitis
    H Togashi
    Second Department of Internal Medicine, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Gut 52:1291-6. 2003
    ..A decrease in colonic mucosal SH compounds affects the redox status of the mucosa, resulting in vulnerability to further attacks. Therefore, there is a strong need for in vivo evaluation of SH compounds in the colonic mucosa...
  56. ncbi Nile Red-adsorbed gold nanoparticle matrixes for determining aminothiols through surface-assisted laser desorption/ionization mass spectrometry
    Yu-Fen Huang
    Department of Chemistry, National Taiwan University, 1, Section 4, Roosevelt Road, Taipei, Taiwan
    Anal Chem 78:1485-93. 2006
    ..We validated the applicability of our method through the analyses of GSH in red blood cells and of Cys in plasma; we believe that this approach has great potential for diagnosis...
  57. ncbi Suitability of boron carriers for BNCT: accumulation of boron in malignant and normal liver cells after treatment with BPA, BSH and BA
    F I Chou
    Nuclear Science and Technology Development Center, National Tsing Hua University, Taiwan, ROC
    Appl Radiat Isot 67:S105-8. 2009
    ..BSH had higher retention in liver but low level in pancreas and spleen appears to be a better candidate BNCT drug for hepatoma. These preliminary results provide useful information on future application of BNCT for hepatoma...
  58. ncbi Role of protein -SH groups in redox homeostasis--the erythrocyte as a model system
    P Di Simplicio
    Department of Environmental Biology, University of Siena, Via Mattioli 4, Siena, 53100, Italy
    Arch Biochem Biophys 355:145-52. 1998
    ..Species with relatively high PSH reactivity and glucose 6-phosphate dehydrogenase activity, such as the rat, therefore had a higher antioxidant capacity than species (calf) in which these parameters were relatively low...
  59. ncbi Mechanisms of gastroprotection by lansoprazole pretreatment against experimentally induced injury in rats: role of mucosal oxidative damage and sulfhydryl compounds
    Gianfranco Natale
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Toxicol Appl Pharmacol 195:62-72. 2004
    ..F(2alpha) (indices of lipid peroxidation), as well as a decrease in the levels of mucosal sulfhydryl compounds, assayed as reduced glutathione (GSH)...
  60. ncbi Reversible cysteine-targeted oxidation of proteins during renal oxidative stress
    Philip Eaton
    The Centre for Cardiovascular Biology and Medicine, The Rayne Institute, St Thomas Hospital, King s College London, London, United Kingdom
    J Am Soc Nephrol 14:S290-6. 2003
    ..These represent proteins that may be functionally regulated by S-thiolation and thus could undergo a change in activity or function after renal ischemia and reperfusion...
  61. ncbi Purification and characterization of thiol-specific antioxidant protein from human red blood cell: a new type of antioxidant protein
    Y S Lim
    Department of Biochemistry, Pai Chai University, Taejon, Republic of Korea
    Biochem Biophys Res Commun 199:199-206. 1994
    ..These observations suggest that HRPRP could act as a new type of antioxidant protein to maintain the RBC integrity by scavenging reactive oxygen species...
  62. ncbi Identification of thioredoxin h-reducible disulphides in proteomes by differential labelling of cysteines: insight into recognition and regulation of proteins in barley seeds by thioredoxin h
    Kenji Maeda
    Department of Chemistry, Carlsberg Laboratory, Copenhagen, Denmark
    Proteomics 5:1634-44. 2005
    ..For the first time, specificity of thioredoxin h for particular disulphide bonds is demonstrated, providing a basis to study structural aspects of the recognition mechanism and regulation of target proteins...
  63. ncbi Functionally active t1-t1 interfaces revealed by the accessibility of intracellular thiolate groups in kv4 channels
    Guangyu Wang
    Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Gen Physiol 126:55-69. 2005
    ..These results conclusively demonstrate that the T1--T1 interface of Kv4 channels is functionally active and dynamic, and that critical reactive thiolate groups in this interface may not be protected by Zn(2+) binding...
  64. ncbi The relationship between plasma levels of oxidized and reduced thiols and early atherosclerosis in healthy adults
    Salman Ashfaq
    Division of Cardiology, University of Kansas School of Medicine, Wichita, Kansas, USA
    J Am Coll Cardiol 47:1005-11. 2006
    ..This finding supports a role for oxidative stress in the pathogenesis of premature atherosclerosis, and its measurement may help in the early identification of asymptomatic subjects at risk of atherosclerotic disease...
  65. ncbi Redox modifications of protein-thiols: emerging roles in cell signaling
    Saibal Biswas
    Department of Biochemistry, Dr. Ambedkar College, Nagpur, Maharashtra State, India
    Biochem Pharmacol 71:551-64. 2006
    ....
  66. ncbi Defining the plant disulfide proteome
    Kyunghee Lee
    Division of Applied Life Science, Gyeongsang National University, Chinju, Korea
    Electrophoresis 25:532-41. 2004
    ..Possible functions of disulfide bonding in these proteins are discussed...
  67. ncbi Probing the disulfide folding pathway of insulin-like growth factor-I
    S J Milner
    GroPep Pty, Ltd, Adelaide, Australia
    Biotechnol Bioeng 62:693-703. 1999
    ..Finally, we apply this pathway to IGF-I and conclude that the divergence in the in vitro folding pathway of IGF-I is caused by non-native interactions involving Glu3 that stabilize the alternative structure...
  68. ncbi Quantifying the global cellular thiol-disulfide status
    Rosa E Hansen
    Department of Biology, University of Copenhagen, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    Proc Natl Acad Sci U S A 106:422-7. 2009
    ..Accordingly, protein thiols are likely to be directly involved in the cellular defense against oxidative stress...
  69. ncbi Self-assembled monolayers of thiolates on metals as a form of nanotechnology
    J Christopher Love
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Chem Rev 105:1103-69. 2005
  70. ncbi Dosimetric study of boron neutron capture therapy with borocaptate sodium (BSH)/lipiodol emulsion (BSH/lipiodol-BNCT) for treatment of multiple liver tumors
    Minoru Suzuki
    Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, Osaka, Japan
    Int J Radiat Oncol Biol Phys 58:892-6. 2004
    ....
  71. ncbi General method to identify and enrich vicinal thiol proteins present in intact cells in the oxidized, disulfide state
    C Gitler
    Department of Membrane Research and Biophysics, Weizmann Institute of Science, Rehovot, Israel
    Anal Biochem 252:48-55. 1997
    ..This method allows sensitive direct identification of vicinal thiol proteins that participate in redox regulation and those that are targets to oxidative stress conditions...
  72. ncbi Biodistribution of 10B in a rat liver tumor model following intra-arterial administration of sodium borocaptate (BSH)/degradable starch microspheres (DSM) emulsion
    Minoru Suzuki
    Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, Noda, Kumatori cho, Sennan gun, Osaka 590 0494, Japan
    Appl Radiat Isot 61:933-7. 2004
    ..However, the high (10)B accumulation in the liver tumors following intra-arterial administration of BSH/DSM emulsion suggests that BSH/DSM-BNCT has the potential for application to malignant tumors in other sites...
  73. ncbi Detection of reactive oxygen species-sensitive thiol proteins by redox difference gel electrophoresis: implications for mitochondrial redox signaling
    Thomas R Hurd
    Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust Medical Research Council Building, Hills Road, Cambridge, UK
    J Biol Chem 282:22040-51. 2007
    ..Thiol redox modification affected enzyme activity, suggesting that the reversible modification of enzyme activity by ROS from the respiratory chain may be an important and unexplored mode of mitochondrial redox signaling...
  74. ncbi The role of low molecular weight thiols in T lymphocyte proliferation and IL-2 secretion
    Tanja Hadzic
    Department of Pathology, University of Iowa, Iowa City, 52242, USA
    J Immunol 175:7965-72. 2005
    ..Importantly, exogenous IL-2 completely overcame BSO-induced block of T cell proliferation. These results demonstrate that T cell proliferation is regulated by thiol-sensitive pathway involving IL-2...
  75. ncbi Role of protein disulfide isomerase and other thiol-reactive proteins in HIV-1 envelope protein-mediated fusion
    Wu Ou
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Building 4, Room 336, Bethesda, MD 20892, USA
    Virology 350:406-17. 2006
    ..We discuss the implications of these observations for identification of molecules involved in disulfide rearrangements in Env during fusion...
  76. ncbi Biochemical and biological aspects of protein thiolation in cells and plasma
    Paolo Di Simplicio
    Department of Neuroscience, Pharmacology Unit, University of Siena, Siena, Italy
    Antioxid Redox Signal 7:951-63. 2005
    ..Here we provide an overview of protein thiolation/dethiolation processes, with an emphasis on recent developments and future perspectives in this field...
  77. ncbi Thiol-based redox metabolism of protozoan parasites
    Sylke Muller
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, DD1 5EH, Dundee, UK
    Trends Parasitol 19:320-8. 2003
    ..In Plasmodium falciparum, the crystal structures of glutathione reductase and glutamate dehydrogenase are now available; another drug target, thioredoxin reductase, has been demonstrated to be essential for the malarial parasite...
  78. ncbi Safety and tolerability of dalcetrapib
    Evan A Stein
    Metabolic and Atherosclerosis Research Center, Cincinnati, OH, USA
    Am J Cardiol 104:82-91. 2009
    ....
  79. ncbi The dual functions of thiol-based peroxidases in H2O2 scavenging and signaling
    Simon Fourquet
    CEA, DSV, iBiTecS, Laboratoire Stress Oxydants et Cancer, CEA Saclay, Gif sur Yvette France
    Antioxid Redox Signal 10:1565-76. 2008
    ..We then discuss possible thiol peroxidase physiologic functions, based on selected observations made in microorganisms and mammals...
  80. ncbi Factors affecting S-homocysteinylation of LDL apoprotein B
    Angelo Zinellu
    Dipartimento di Scienze Biomediche, Cattedra di Biochimica Clinica, Universita degli Studi di Sassari, Sassari, Italy
    Clin Chem 52:2054-9. 2006
    ..Because oxidation and/or homocysteinylation may increase atherogenicity of LDL, we investigated S-homocysteinylation of LDL as a possible contributor to atherosclerosis pathogenesis...
  81. ncbi Piezo dispensed microarray of multivalent chelating thiols for dissecting complex protein-protein interactions
    Goran Klenkar
    Division of Molecular and Applied Physics, Department of Physics, Chemistry, and Biology, , , Sweden
    Anal Chem 78:3643-50. 2006
    ..Thus, multiplexed monitoring of binding phenomena at various compositions (receptor densities) offers a powerful tool to dissect protein-protein interactions...
  82. ncbi Evidence for inactivation of cysteine proteases by reactive carbonyls via glycation of active site thiols
    Jingmin Zeng
    The Heart Research Institute, 145 Missenden Road, Sydney, NSW 2050, Australia
    Biochem J 398:197-206. 2006
    ..This process may contribute to the accumulation of modified proteins in tissues of people with diabetes and age-related pathologies, including atherosclerosis, cataract and Alzheimer's disease...
  83. ncbi Association between oral malodor and measurements obtained using a new sulfide monitor
    Praweena Sopapornamorn
    Department of Oral Health Promotion, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo, Japan
    J Dent 34:770-4. 2006
    ..The purpose of this study was to evaluate the ability of a new volatile sulfur compounds (VSCs) monitor to assess oral malodor in subjects and compare its performance with those of organoleptic testing and gas chromatography...
  84. ncbi Dominant-negative modification reveals the regulatory function of the multimeric cysteine synthase protein complex in transgenic tobacco
    Markus Wirtz
    Heidelberg Institute of Plant Sciences, University of Heidelberg, 69120 Heidelberg, Germany
    Plant Cell 19:625-39. 2007
    ..These data provide evidence that the CSC and its subcellular compartmentation play a crucial role in the control of Cys biosynthesis, a unique function for a plant metabolic protein complex...
  85. ncbi Biochemical characterization of cholesteryl ester transfer protein inhibitors
    Mollie Ranalletta
    Merck Research Laboratories, Rahway, NJ 07065, USA
    J Lipid Res 51:2739-52. 2010
    ..Each CETP inhibitor induced tight binding of CETP to HDL, indicating that these inhibitors promote the formation of a complex between CETP and HDL, resulting in inhibition of CETP activity...
  86. ncbi Persistent S-nitrosation of complex I and other mitochondrial membrane proteins by S-nitrosothiols but not nitric oxide or peroxynitrite: implications for the interaction of nitric oxide with mitochondria
    Christina C Dahm
    Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust/Medical Research Council Building, Hills Road, Cambridge CB2 2XY, United Kingdom
    J Biol Chem 281:10056-65. 2006
    ..These findings point to a significant role for complex I S-nitrosation and consequent dysfunction during nitrosative stress in disorders such as Parkinson disease and sepsis...
  87. ncbi Thiol metabolism and antioxidant systems complement each other during arsenate detoxification in Ceratophyllum demersum L
    Seema Mishra
    Ecotoxicology and Bioremediation Group, National Botanical Research Institute, Rana Pratap Marg, Lucknow 226001, India
    Aquat Toxicol 86:205-15. 2008
    ....
  88. ncbi Effects of N-acetylcysteine and glutathione ethyl ester drops on streptozotocin-induced diabetic cataract in rats
    Shu Zhang
    Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Mol Vis 14:862-70. 2008
    ..To evaluate the effect of N-acetylcysteine (NAC) and glutathione ethyl ester (GSH-EE) eye drops on the progression of diabetic cataract formation induced by streptozotocin (STZ)...
  89. ncbi A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury
    Tracy A Prime
    MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, United Kingdom
    Proc Natl Acad Sci U S A 106:10764-9. 2009
    ..These results support the idea that selectively targeting NO(*) donors to mitochondria is an effective strategy to reversibly modulate respiration and to protect mitochondria against ischemia-reperfusion injury...
  90. ncbi The Role of zinc in the disulphide stress-regulated anti-sigma factor RsrA from Streptomyces coelicolor
    Wei Li
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    J Mol Biol 333:461-72. 2003
    ..Redox stress induces disulphide bond formation amongst zinc-ligating residues, expelling the metal ion and stabilising a structure incapable of binding the sigma factor...
  91. ncbi Proteomic analysis of S-nitrosylation and denitrosylation by resin-assisted capture
    Michael T Forrester
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, USA
    Nat Biotechnol 27:557-9. 2009
    ..This methodology is readily adapted to analyzing diverse cysteine-based protein modifications, including S-acylation...
  92. ncbi Cysteine regulation of protein function--as exemplified by NMDA-receptor modulation
    Stuart A Lipton
    Center for Neuroscience and Aging, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Trends Neurosci 25:474-80. 2002
    ..This article reviews the basis for these molecular cysteine switches, drawing on the NMDA receptor as an exemplary protein, and proposes a molecular model for the action of S-nitrosylation based on recently derived crystal structures...
  93. ncbi Protein-thiol oxidation, from single proteins to proteome-wide analyses
    Natacha Le Moan
    CEA, DSV, iBiTecS, SBIGeM, Laboratoire Stress Oxydants et Cancer, Gif sur Yvette, France
    Methods Mol Biol 476:181-98. 2008
    ..Proteome-wide approaches also contributed to establish the functions of the thioredoxin and glutathione pathways in eukaryotic cytoplasmic thiol-redox control...
  94. ncbi Copper dependence of the biotin switch assay: modified assay for measuring cellular and blood nitrosated proteins
    Xunde Wang
    Pulmonary and Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 44:1362-72. 2008
    ..The addition of copper to ascorbate allows for a simple assay modification that dramatically increases sensitivity while maintaining specificity...
  95. ncbi Conformational fluctuations coupled to the thiol-disulfide transfer between thioredoxin and arsenate reductase in Bacillus subtilis
    You Li
    Beijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
    J Biol Chem 282:11078-83. 2007
    ..Our current studies provide novel insights into understanding the reaction mechanisms of the thioredoxin-arsenate reductase pathway...
  96. ncbi ortho- and meta-substituted aromatic thiols are efficient redox buffers that increase the folding rate of a disulfide-containing protein
    Jonathan D Gough
    Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA
    J Biotechnol 125:39-47. 2006
    ..In the presence of the common denaturant guanidine hydrochloride (0.5M) aromatic thiols provided 100% yield of active protein while maintaining equivalent folding rates...
  97. ncbi Homocysteine- and cysteine-mediated growth defect is not associated with induction of oxidative stress response genes in yeast
    Arun Kumar
    Institute of Genomics and Integrative Biology, Mall Road, Delhi-110007, India
    Biochem J 396:61-9. 2006
    ....
  98. ncbi Global methods to monitor the thiol-disulfide state of proteins in vivo
    Lars I Leichert
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, 48109-1048, USA
    Antioxid Redox Signal 8:763-72. 2006
    ..This review will provide an overview of the current techniques, focus on approaches to quantitatively describe the extent of thiol modification in vivo, and summarize their applications...
  99. ncbi The organoselenium compound 1,4-phenylenebis(methylene)selenocyanate inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorgenesis and enhances glutathione-related antioxidant levels in A/J mouse lung
    John P Richie
    Department of Health Evaluation Sciences, Penn State Cancer Institute, Penn State University, Milton S. Hershey Medical Center, PA 17033, USA
    Chem Biol Interact 161:93-103. 2006
    ....
  100. ncbi Thioredoxin reductase is essential for thiol/disulfide redox control and oxidative stress survival of the anaerobe Bacteroides fragilis
    Edson R Rocha
    Department of Microbiology and Immunology, East Carolina University Brody School of Medicine, 600 Moye Blvd, Greenville, NC 27834, USA
    J Bacteriol 189:8015-23. 2007
    ..Taken together, these data strongly suggest that TrxB/Trx is the major, if not the sole, thiol/disulfide redox system in this anaerobe required for survival and abscess formation in a peritoneal cavity infection model...
  101. ncbi Thiol-based regulation of redox-active glutamate-cysteine ligase from Arabidopsis thaliana
    Leslie M Hicks
    Donald Danforth Plant Science Center, St Louis, Missouri 63132, USA
    Plant Cell 19:2653-61. 2007
    ....

Research Grants126 found, 100 shown here

  1. CHEMICAL SYNTESIS OF BETA MANNO- AND RHAMNOPYRANOSIDES
    David Crich; Fiscal Year: 2001
    ....
  2. A metabolomic model of aging in the common marmoset
    DANIEL EDWARD LEE PROMISLOW; Fiscal Year: 2010
    ..The acquired knowledge has the potential to explain causes of variation in traits of aging within individuals and also differences in aging among individuals in human populations. ..
  3. Methods and Mechanisms in Carbohydrate Chemistry
    David Crich; Fiscal Year: 2003
    ..It is hoped that an enhanced understanding of the poor reactivity of these species will enable the development of protecting groups and conditions to circumvent it. ..
  4. Methods and Mechanisms in Carbohydrate Chemistry
    David Crich; Fiscal Year: 2007
    ....
  5. Nuclear and Cytoplasmic Redox in Oxidative Stress
    Dean Jones; Fiscal Year: 2007
    ....
  6. Chemical Synthesis of Beta-Manno and Rehamnopyranosides
    David Crich; Fiscal Year: 2007
    ....
  7. Nuclear and Cytoplasmic Redox in Oxidative Stress
    Dean Jones; Fiscal Year: 2009
    ....
  8. Thioredoxin-2 protection against mitochondrial oxidative toxicity
    Dean P Jones; Fiscal Year: 2010
    ..This is of considerable importance because therapeutic agents which eliminate reactive species could also disrupt normal signaling. ..
  9. Nuclear and Cytoplasmic Redox in Oxidative Stress
    Dean P Jones; Fiscal Year: 2010
    ....
  10. MITOCHONDRIA IN CHEMICAL-INDUCED APOPTOSIS
    Dean Jones; Fiscal Year: 2007
    ..Aims 1 and 2 will substantially add to basic knowledge of human mtTrx and Aims 3 and 4 will define whether mtTrx has a central function in protection against chemical-induced toxicity. ..
  11. Chemical Synthesis of Beta Manno-and Rhamnopyranosides
    David Crich; Fiscal Year: 2005
    ..Accordingly, it is necessary that any truly valuable method be demonstrated to be readily transferable between the two phases. ..
  12. Nuclear and Cytoplasmic Redox in Oxidative Stress
    Dean Jones; Fiscal Year: 2005
    ....
  13. Metabolic effects of chemical interactions in toxicity
    Dean Jones; Fiscal Year: 2005
    ....
  14. Thioredoxin-2 protection against mitochondrial oxidative toxicity
    Dean P Jones; Fiscal Year: 2011
    ..This is of considerable importance because therapeutic agents which eliminate reactive species could also disrupt normal signaling. ..
  15. Metabolic analysis in human sulfur amino acid deficiency
    Dean Jones; Fiscal Year: 2005
    ..g., 300 samples/day with a flow cell), results will show whether this approach could be useful for nutritional assessment of complex metabolic effects of SAA intake. ..
  16. MITOCHONDRIA IN CHEMICAL-INDUCED APOPTOSIS
    Dean Jones; Fiscal Year: 2001
    ..These studies will clarify the role of mitochondria in chemical-induced cell death and provide important new information concerning the mechanistic basis for apoptotic cell death induced by mitochondrial toxicants. ..
  17. PP2A-Like Constitutive ERK/MAPK Phosphatase in Brain
    Timothy Foley; Fiscal Year: 2003
    ....
  18. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
    ..The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease. ..
  19. SYNTHESIS OF PHYLLANTHOSIDE RELATED ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 1991
    ..Once such features are identified, the design of new and possibly more effective antitumor drugs should be feasible...
  20. Pilot-Scale Libraries for High-throughput Screening
    AMOS SMITH; Fiscal Year: 2007
    ....
  21. Structural Biology of the S. elongatus Circadian Clock
    Martin Egli; Fiscal Year: 2010
    ....
  22. Design and Synthesis of HIV-1 Protease Inhibitors
    AMOS SMITH; Fiscal Year: 2004
    ....
  23. METABOLISM AND TOXICITY OF HYDROQUINONE-THIOETHERS
    Serrine Lau; Fiscal Year: 2003
    ..The overall goals of this aim are to characterize the Eker animal model in which the effects of environmental influences (chemical exposure) on a genetic predisposition to cancer are determined. ..
  24. SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTER
    Serrine Lau; Fiscal Year: 2007
    ..This last goal is synergistic with the objective of extending basic research discoveries into the clinical and public health arenas. ..