sulfhydryl compounds

Summary

Summary: Compounds containing the -SH radical.

Top Publications

  1. ncbi Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
    F Q Schafer
    Free Radical Research Institute and ESR Facility, The University of Iowa, Iowa City, IA 52242 1101, USA
    Free Radic Biol Med 30:1191-212. 2001
  2. ncbi Protein S-nitrosylation: purview and parameters
    Douglas T Hess
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Mol Cell Biol 6:150-66. 2005
  3. pmc Quantifying the global cellular thiol-disulfide status
    Rosa E Hansen
    Department of Biology, University of Copenhagen, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    Proc Natl Acad Sci U S A 106:422-7. 2009
  4. doi Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial
    Zahi A Fayad
    Translational and Molecular Imaging Institute and Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Lancet 378:1547-59. 2011
  5. ncbi Redox modifications of protein-thiols: emerging roles in cell signaling
    Saibal Biswas
    Department of Biochemistry, Dr Ambedkar College, Nagpur, Maharashtra State, India
    Biochem Pharmacol 71:551-64. 2006
  6. doi Cysteinylation and homocysteinylation of plasma protein thiols during ageing of healthy human beings
    R Rossi
    Department of Evolutionary Biology, University of Siena, Siena, Italy
    J Cell Mol Med 13:3131-40. 2009
  7. pmc Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport
    Eric J Niesor
    Pharmaceuticals Division, F Hoffmann La Roche Ltd, Basel, Switzerland
    J Lipid Res 51:3443-54. 2010
  8. ncbi Quick measurement of protein sulfhydryls with Ellman's reagent and with 4,4'-dithiodipyridine
    Christian K Riener
    Institute of Biophysics, J Kepler University, Altenberger Str 69, A 4040 Linz, Austria
    Anal Bioanal Chem 373:266-76. 2002
  9. ncbi Thiolated polymers--thiomers: development and in vitro evaluation of chitosan-thioglycolic acid conjugates
    C E Kast
    Institute of Pharmaceutical Technology and Biopharmaceutics, Center of Pharmacy, University of Vienna, Austria
    Biomaterials 22:2345-52. 2001
  10. ncbi S-glutathionylation in protein redox regulation
    Isabella Dalle-Donne
    Department of Biology, University of Milan, I 20133 Milan, Italy
    Free Radic Biol Med 43:883-98. 2007

Detail Information

Publications263 found, 100 shown here

  1. ncbi Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
    F Q Schafer
    Free Radical Research Institute and ESR Facility, The University of Iowa, Iowa City, IA 52242 1101, USA
    Free Radic Biol Med 30:1191-212. 2001
    ..These are the first steps toward a new quantitative biology, which hopefully will provide a rationale and understanding of the cellular mechanisms associated with cell growth and development, signaling, and reductive or oxidative stress...
  2. ncbi Protein S-nitrosylation: purview and parameters
    Douglas T Hess
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Mol Cell Biol 6:150-66. 2005
    ..S-nitrosylation thereby conveys a large part of the ubiquitous influence of nitric oxide (NO) on cellular signal transduction, and provides a mechanism for redox-based physiological regulation...
  3. pmc Quantifying the global cellular thiol-disulfide status
    Rosa E Hansen
    Department of Biology, University of Copenhagen, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    Proc Natl Acad Sci U S A 106:422-7. 2009
    ..Accordingly, protein thiols are likely to be directly involved in the cellular defense against oxidative stress...
  4. doi Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial
    Zahi A Fayad
    Translational and Molecular Imaging Institute and Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Lancet 378:1547-59. 2011
    ..dal-PLAQUE is the first multicentre study using novel non-invasive multimodality imaging to assess structural and inflammatory indices of atherosclerosis as primary endpoints...
  5. ncbi Redox modifications of protein-thiols: emerging roles in cell signaling
    Saibal Biswas
    Department of Biochemistry, Dr Ambedkar College, Nagpur, Maharashtra State, India
    Biochem Pharmacol 71:551-64. 2006
    ....
  6. doi Cysteinylation and homocysteinylation of plasma protein thiols during ageing of healthy human beings
    R Rossi
    Department of Evolutionary Biology, University of Siena, Siena, Italy
    J Cell Mol Med 13:3131-40. 2009
    ..The drop in the plasma level of protein sulphydryl groups suggests depletion and/or impairment of the antioxidant capacity of plasma, likely related to an alteration of the delicate balance between the different redox forms of thiols...
  7. pmc Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport
    Eric J Niesor
    Pharmaceuticals Division, F Hoffmann La Roche Ltd, Basel, Switzerland
    J Lipid Res 51:3443-54. 2010
    ..These data suggest that modulation of CETP activity by dalcetrapib does not inhibit CETP-induced pre-β-HDL formation, which may be required to increase reverse cholesterol transport...
  8. ncbi Quick measurement of protein sulfhydryls with Ellman's reagent and with 4,4'-dithiodipyridine
    Christian K Riener
    Institute of Biophysics, J Kepler University, Altenberger Str 69, A 4040 Linz, Austria
    Anal Bioanal Chem 373:266-76. 2002
    ..Electronic supplementary material to this paper can be obtained by using the Springer Link server located at http://dx.doi.org/10.1007/s00216-002-1347-2...
  9. ncbi Thiolated polymers--thiomers: development and in vitro evaluation of chitosan-thioglycolic acid conjugates
    C E Kast
    Institute of Pharmaceutical Technology and Biopharmaceutics, Center of Pharmacy, University of Vienna, Austria
    Biomaterials 22:2345-52. 2001
    ..According to these results. chitosan-TGA conjugates represent a promising tool for the development of mucoadhesive drug delivery systems...
  10. ncbi S-glutathionylation in protein redox regulation
    Isabella Dalle-Donne
    Department of Biology, University of Milan, I 20133 Milan, Italy
    Free Radic Biol Med 43:883-98. 2007
    ..In this review, we describe recent breakthroughs in our understanding of the potential role of protein S-glutathionylation in the redox regulation of signal transduction...
  11. ncbi Molecular mechanisms and potential clinical significance of S-glutathionylation
    Isabella Dalle-Donne
    Department of Biology, University of Milan, Milan, Italy
    Antioxid Redox Signal 10:445-73. 2008
    ..Recently, specific PSSG have been identified in the inferior parietal lobule in Alzheimer's disease. However, much investigation is needed to clarify the actual involvement of protein S-glutathionylation in many human diseases...
  12. pmc Quantifying changes in the thiol redox proteome upon oxidative stress in vivo
    Lars I Leichert
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 North University, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 105:8197-202. 2008
    ..These experiments illustrate that OxICAT, which can be used in a variety of different cell types and organisms, is a powerful tool to identify, quantify, and monitor oxidative thiol modifications in vivo...
  13. ncbi The high reactivity of peroxiredoxin 2 with H(2)O(2) is not reflected in its reaction with other oxidants and thiol reagents
    Alexander V Peskin
    Free Radical Research Group, Department of Pathology, University of Otago, P O Box 4345, Christchurch, New Zealand
    J Biol Chem 282:11885-92. 2007
    ..These results demonstrate that peroxiredoxin 2 has a tertiary structure that facilitates reaction of the active site thiol with hydrogen peroxide while restricting its reactivity with other thiol reagents...
  14. doi Is raising HDL a futile strategy for atheroprotection?
    Tisha Joy
    Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada, N6A 5K8
    Nat Rev Drug Discov 7:143-55. 2008
    ..In this article, we review the complexity of HDL metabolism, discuss clinical-trial data for HDL-raising agents, including possible reasons for the failure of torcetrapib, and consider the potential for future HDL-based therapies...
  15. doi Fluorescent and colorimetric probes for detection of thiols
    Xiaoqiang Chen
    Department of Chemistry and Nano Science BK 21, Ewha Womans University, Seoul 120 750, Korea
    Chem Soc Rev 39:2120-35. 2010
    ....
  16. ncbi Elaboration and characterization of thiolated chitosan-coated acrylic nanoparticles
    Irene Bravo-Osuna
    Laboratoire de Physicochimie, Pharmacotechnie et Biopharmacie, UMR CNRS 8612 Université Paris XI, Faculte de Pharmacie, 5, rue J B Clement, 92296 Chatenay Malabry, France
    Int J Pharm 316:170-5. 2006
    ..This new system, combining both the advantages of thiolated polymers and colloidal particles can be proposed as an original drug carrier system for mucosal delivery of biotechnology products...
  17. doi Palladacycles catalyse the oxidation of critical thiols of the mitochondrial membrane proteins and lead to mitochondrial permeabilization and cytochrome c release associated with apoptosis
    Debora P Santana
    Centro Interdisciplinar de Investigação Bioquímica CIIB, Universidade de Mogi das Cruzes UMC, Av Dr Cândido Xavier de Almeida e Souza, 200 Mogi das Cruzes, Sao Paulo, Brazil
    Biochem J 417:247-56. 2009
    ..Besides the contribution to clarify the pro-apoptotic mechanism of PdC, this study shows that the catalysis of specific protein thiol cross-linkage is enough to induce mitochondrial permeabilization and cytochrome c release...
  18. ncbi Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, The Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biochemistry 44:6889-99. 2005
    ..Keap1 is a zinc-thiol protein endowed with a delicate switch controlled by both metal-binding and thiol reactivity...
  19. ncbi Nitric oxide activates TRP channels by cysteine S-nitrosylation
    Takashi Yoshida
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615 8510, Japan
    Nat Chem Biol 2:596-607. 2006
    ..These findings reveal the structural motif for the NO-sensitive activation gate in TRP channels and indicate that NO sensors are a new functional category of cellular receptors extending over different TRP families...
  20. ncbi Allosteric disulfide bonds
    Bryan Schmidt
    Centre for Vascular Research, University of New South Wales and Department of Haematology, Prince of Wales Hospital, Sydney, New South Wales 2052, Australia
    Biochemistry 45:7429-33. 2006
    ..We suggest that the -RHStaple configuration is a hallmark of allosteric disulfides. About 1 in 15 of all structurally determined disulfides is a potential allosteric bond...
  21. pmc Bacillithiol is an antioxidant thiol produced in Bacilli
    Gerald L Newton
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, USA
    Nat Chem Biol 5:625-7. 2009
    ..Bacillithiol is the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid and most probably functions as an antioxidant. Bacillithiol, like the structurally similar mycothiol, may serve as a substitute for glutathione...
  22. pmc Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule
    Amy Trott
    Department of Microbiology and Molecular Genetics, University of Texas Medical School, Houston, TX 77030, USA
    Mol Biol Cell 19:1104-12. 2008
    ....
  23. ncbi The polarization of T(h)1/T(h)2 balance is dependent on the intracellular thiol redox status of macrophages due to the distinctive cytokine production
    Yukie Murata
    Basic Research Laboratories, Ajinomoto Co Inc, 1 1 Suzuki cho, Kawasaki ku, Kawasaki 210 0861, Japan
    Int Immunol 14:201-12. 2002
    ..The findings implicate that the alteration in Mp functions because altered intracellular glutathione may play a relevant role in the pathological progression of inflammation...
  24. pmc Mechanistic and kinetic details of catalysis of thiol-disulfide exchange by glutaredoxins and potential mechanisms of regulation
    MOLLY M GALLOGLY
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    Antioxid Redox Signal 11:1059-81. 2009
    ..Part II presents potential mechanisms for in vivo regulation of Grx activity, providing avenues for future studies...
  25. doi Thioredoxin targets of the plant chloroplast lumen and their implications for plastid function
    Michael Hall
    Department of Chemistry, Umea3 University, Umea3, Sweden
    Proteomics 10:987-1001. 2010
    ..Our results indicate that redox-controlled reactions in the chloroplast lumen play essential roles in the function of photosystem II and the regulation of adaptation to light intensity...
  26. doi Hepatocyte-targeting single galactose-appended naphthalimide: a tool for intracellular thiol imaging in vivo
    Min Hee Lee
    Department of Chemistry, Korea University, Seoul, 136 701, Korea
    J Am Chem Soc 134:1316-22. 2012
    ....
  27. ncbi Thiolated chitosans: development and in vitro evaluation of an oral tobramycin sulphate delivery system
    Juliane Hombach
    Institute of Pharmacy, Leopold Franzens University Innsbruck, Innrain 52, Josef Moller Haus, 6020 Innsbruck, Austria
    Eur J Pharm Sci 33:1-8. 2008
    ..The developed drug delivery system containing chitosan-NAC and glutathione is a promising tool for oral tobramycin sulphate administration showing improved gastrointestinal uptake and a sustained release...
  28. doi Mucoadhesive effect of thiolated PEG stearate and its modified NLC for ocular drug delivery
    Jie Shen
    School of Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China
    J Control Release 137:217-23. 2009
    ..05), compared with the NLC without thiomer modification...
  29. ncbi A rhodamine-based fluorescent probe containing a Se-N bond for detecting thiols and its application in living cells
    Bo Tang
    Chemical Engineering and Materials Science, Engineering Research Center of Pesticide and Medicine Intermediate Clean Production, College of Chemistry, Ministry of Education, Shandong Normal University, Jinan, People s Republic of China
    J Am Chem Soc 129:11666-7. 2007
  30. pmc Vascular effects and safety of dalcetrapib in patients with or at risk of coronary heart disease: the dal-VESSEL randomized clinical trial
    Thomas F Luscher
    Department of Cardiology, Cardiovascular Centre, University of Zurich, 8091 Zurich, Switzerland
    Eur Heart J 33:857-65. 2012
    ..gov number NCT00655538)...
  31. pmc Reaction based fluorescent probes for hydrogen sulfide
    Chunrong Liu
    Department of Chemistry, Washington State University, Pullman, Washington 99164, USA
    Org Lett 14:2184-7. 2012
    ..Other biological thiols such as cysteine and glutathione did not pursue the reaction and therefore did not turn on the fluorescence/consume the substrates. The probes showed good selectivity and sensitivity for hydrogen sulfide...
  32. pmc Preactivated thiomers as mucoadhesive polymers for drug delivery
    Javed Iqbal
    Department of Pharmaceutical Technology, Leopold Franzens University Innsbruck, Innsbruck, Austria
    Biomaterials 33:1528-35. 2012
    ..Thus, on the basis of achieved results the pre-activated thiomers seem to represent a promising generation of mucoadhesive polymers which are safe to use for prolonged residence time of drug delivery systems to target various mucosa...
  33. doi Ratiometric detection of mitochondrial thiols with a two-photon fluorescent probe
    Chang Su Lim
    Department of Chemistry, Korea University, 1 Anamdong, Seoul 136 701, Korea
    J Am Chem Soc 133:11132-5. 2011
    ....
  34. doi Tumor-specific targeting of sodium borocaptate (BSH) to malignant glioma by transferrin-PEG liposomes: a modality for boron neutron capture therapy
    Atsushi Doi
    Department of Neurosurgery, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka 569 8686, Japan
    J Neurooncol 87:287-94. 2008
    ..To improve a drug delivery in BNCT, we devised transferrin-conjugated polyethylene-glycol liposome encapsulating sodium borocaptate (TF-PEG-BSH)...
  35. ncbi Redox proteomics: identification of oxidatively modified proteins
    Pietro Ghezzi
    Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy
    Proteomics 3:1145-53. 2003
    ....
  36. pmc Direct observation of disulfide isomerization in a single protein
    Jorge Alegre-Cebollada
    Department of Biological Sciences, Columbia University, Northwest Corner Building, 550 West 120 Street, New York, New York 10027, USA
    Nat Chem 3:882-7. 2011
    ..This allowed us to measure, for the first time, the kinetics of disulfide-bond isomerization in a protein...
  37. doi Chitosan-graft-6-mercaptonicotinic acid: synthesis, characterization, and biocompatibility
    Gioconda Millotti
    Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold Franzens University, Innrain 52c, Josef Moller Haus, Innsbruck, Austria
    Biomacromolecules 10:3023-7. 2009
    ..The reactivity of thiol groups was in the same range at pH 3 and pH 6.8. According to these results, chitosan-6 mercaptonicotinic acid seems to have some promising features to be used particularly for mucoadhesive formulations...
  38. doi SIN-1 cytotoxicity to PC12 cells is mediated by thiol-sensitive short-lived substances generated through SIN-1 decomposition in culture medium
    Kanako Konishi
    Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, Japan
    Nitric Oxide 20:270-8. 2009
    ..These results suggest that SIN-1 cytotoxicity in PC12 cells is mediated via the generation of cytotoxic substances in the medium during its decomposition...
  39. doi Albumin-bound low molecular weight thiols analysis in plasma and carotid plaques by CE
    Angelo Zinellu
    Dept Biomedical Sciences, University of Sassari, Sassari, Italy
    J Sep Sci 33:126-31. 2010
    ..Due to the elevated sensitivity (LOD of 0.3 pM for all thiols), also low molecular weight thiols bound to albumin filtered in tissues could be quantified...
  40. doi Different effects of compounds decreasing cholesteryl ester transfer protein activity on lipoprotein metabolism
    Eric J Niesor
    Pharmaceuticals Division, F Hoffmann La Roche Ltd, Basel, Switzerland
    Curr Opin Lipidol 22:288-95. 2011
    ....
  41. doi Thiol chemistry and specificity in redox signaling
    Christine C Winterbourn
    Free Radical Research Group and the National Research Centre for Growth and Development, Department of Pathology, University of Otago, Christchurch, New Zealand
    Free Radic Biol Med 45:549-61. 2008
    ..We discuss areas where observations in cell systems can be rationalized with the reactivity of specific oxidants and where further work is needed to understand the mechanisms involved...
  42. doi Anacetrapib and dalcetrapib: two novel cholesteryl ester transfer protein inhibitors
    Marta A Miyares
    Pharmacy Department, Jackson Memorial Hospital, Miami, FL, USA
    Ann Pharmacother 45:84-94. 2011
    ....
  43. doi Gastroprotective mechanisms of Citrus lemon (Rutaceae) essential oil and its majority compounds limonene and β-pinene: involvement of heat-shock protein-70, vasoactive intestinal peptide, glutathione, sulfhydryl compounds, nitric oxide and prostaglandin E
    Ariane Leite Rozza
    Morphology Department, Biosciences Institute, Univ Estadual Paulista, Botucatu, SP, Brazil
    Chem Biol Interact 189:82-9. 2011
    ..CL gastroprotective mechanism is involved with PGE₂. PIN did not present gastroprotective activity...
  44. pmc Drevogenin D prevents selenite-induced oxidative stress and calpain activation in cultured rat lens
    P G Biju
    Department of Biochemistry, University of Kerala, Kerala, India
    Mol Vis 13:1121-9. 2007
    ..The purpose of the study was to evaluate the role of Drevogenin D, a triterpenoid aglycone, isolated from Dregea volubilis in preventing selenite-induced, calcium-activated, calpain-mediated proteolysis in cultured rat lenses...
  45. doi Cell-surface thiols affect cell entry of disulfide-conjugated peptides
    Soline Aubry
    UPMC Universite Paris 06, UMR 7613, Synthesis, Structure, and Function of Bioactive Molecules, Paris, France
    FASEB J 23:2956-67. 2009
    ....
  46. pmc Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
    A T Dinkova-Kostova
    Department of Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:3404-9. 2001
    ..This enhancement correlates with more rapid reactivity of the ortho-hydroxylated derivatives with model sulfhydryl compounds. Proton NMR spectroscopy provides no evidence for increased electrophilicity of the beta-vinyl carbons (the ..
  47. ncbi Tuning of shell and core characteristics of chitosan-decorated acrylic nanoparticles
    I Bravo-Osuna
    CNRS, UMR CNRS 8612, Faculte de Pharmacie, 5 rue J B Clement, 92296 Chatenay Malabry, France
    Eur J Pharm Sci 30:143-54. 2007
    ..Positive surface charge values were obtained in all cases. In addition, evidences of the presence of thiol groups were obtained (0.03-0.16 x 10(-3)micromol/cm(2) of nanoparticle)...
  48. pmc Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage
    Raquel Requejo
    MRC Mitochondrial Biology Unit, Wellcome Trust MRC Building, Cambridge, UK
    FEBS J 277:1465-80. 2010
    ..Therefore, exposed protein thiols are the dominant free thiol within the cell and may play a critical role in intracellular antioxidant defences against oxidative damage...
  49. ncbi OxyR: a molecular code for redox-related signaling
    Sung Oog Kim
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 109:383-96. 2002
    ....
  50. pmc Cystic fibrosis transmembrane conductance regulator: using differential reactivity toward channel-permeant and channel-impermeant thiol-reactive probes to test a molecular model for the pore
    Christopher Alexander
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Biochemistry 48:10078-88. 2009
    ..The results provide an initial validation of two, new molecular models for CFTR and suggest that molecular dynamics simulation will be a useful tool for unraveling the structural basis of anion conduction by CFTR...
  51. ncbi A bystander effect observed in boron neutron capture therapy: a study of the induction of mutations in the HPRT locus
    Yuko Kinashi
    Research Reactor Institute, Kyoto University, Osaka, Japan
    Int J Radiat Oncol Biol Phys 68:508-14. 2007
    ..The BSH-containing cells were irradiated with alpha-particles produced by the 10B(n,alpha)7Li reaction, whereas cells without boron were affected only by the 1H(n,gamma)2H and 14N(n,rho)14C reactions...
  52. ncbi Monofunctional gold nanoparticles prepared via a noncovalent-interaction-based solid-phase modification approach
    Xiong Liu
    Nanoscience Technology Center and Department of Chemistry, University of Central Florida, 12424 Research Parkway Suit 400, Orlando, FL 32826, USA
    Small 2:1126-9. 2006
  53. ncbi Reactive oxygen metabolites and prooxidant status in children with Down's syndrome
    M Carratelli
    Diacron S.r.l, Diagnostic Division, Grosseto, Italy
    Int J Clin Pharmacol Res 21:79-84. 2001
    ..The new test available for measuring reactive oxygen species in serum proved to be reliable and useful as an early marker of tissue damage...
  54. ncbi Analysis of plasma thiols by high-performance liquid chromatography with ultraviolet detection
    E Bald
    Department of Environmental Chemistry, University of Lodz, 163 Pomorska Street, 90 236 Lodz, Poland
    J Chromatogr A 1032:109-15. 2004
    ..The method is linear within the physiological and pathological ranges of thiols and is applied for plasma samples donated by apparently healthy volunteers...
  55. doi Proteomics of Arabidopsis redox proteins in response to methyl jasmonate
    Sophie Alvarez
    Department of Botany and Zoology, Genetics Institute, The Plant Molecular and Cellular Biology Program, University of Florida, Gainesville, FL 32611, USA
    J Proteomics 73:30-40. 2009
    ..Identification of redox proteins and their cysteine residues involved in the redox regulation allows for a deeper understanding of the jasmonate signaling networks...
  56. ncbi Plasma thiols redox status by laser-induced fluorescence capillary electrophoresis
    Ciriaco Carru
    Chair of Clinical Biochemistry, University of Sassari, Viale San Pietro 43 B, I 07100 Sassari, Italy
    Electrophoresis 25:882-9. 2004
    ..Linearity, reproducibility, analytical recovery, and sensitivity were evaluated. The assay was used to measure the thiols redox status in 15 plasma samples from healthy volunteers...
  57. ncbi Bioelectronic detector with monoamine oxidase for halitosis monitoring
    T Minamide
    Graduate School of Engineering, Tokai University, Hiratsuka, Japan
    Analyst 130:1490-4. 2005
    ..The output of bio-detector showed behaviour of halitosis level changes in a day such as increasing with passage of time and decreasing after eating...
  58. ncbi Oxidoreduction of protein thiols in redox regulation
    P Ghezzi
    Mario Negri Institute, Via Eritrea 62, 20157 Milan, Italy
    Biochem Soc Trans 33:1378-81. 2005
    ..This review discusses the evolution of the concept of redox regulation from that of oxidative stress and the redox state of protein cysteines in different cellular compartments...
  59. ncbi Redox state of glutathione in human plasma
    D P Jones
    Department of Biochemistry, Atlanta, GA, USA
    Free Radic Biol Med 28:625-35. 2000
    ..These results suggest that E(h) values for GSSG/2GSH and CySS-mono-Gly/(Cys. CysGly) may provide useful means to quantitatively express the oxidant/antioxidant balance in clinical and epidemiologic studies...
  60. ncbi A sensitive method for the quantitative measurement of protein thiol modification in response to oxidative stress
    Aimee Landar
    Department of Pathology, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Free Radic Biol Med 40:459-68. 2006
    ..Thus, we have developed a versatile, cost-effective standard that can be used in proteomic methods to quantitate biotin tags in response to oxidative stress...
  61. ncbi Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: thiomer/GSH systems
    A Bernkop-Schnürch
    Institute of Pharmaceutical Technology and Biopharmaceutics, Center of Pharmacy, University of Vienna, Althanstr 14, A 1090 Vienna, Austria
    J Control Release 93:95-103. 2003
    ....
  62. ncbi The role of thiols and disulfides in platelet function
    David W Essex
    Department of Medicine Division of Hematology, The University of Texas Health Science Center at San Antonio, 78229, USA
    Antioxid Redox Signal 6:736-46. 2004
    ..We here provide an overview of this field with a focus on recent developments, and conclude with a working model...
  63. ncbi Age-related influence on thiol, disulfide, and protein-mixed disulfide levels in human plasma
    Daniela Giustarini
    Department of Neuroscience, Pharmacology Unit, University of Siena, Via A Moro 4, I 53100, Siena, Italy
    J Gerontol A Biol Sci Med Sci 61:1030-8. 2006
    ..The occurrence of two distinct regulatory systems for plasmatic pools of glutathione/cysteinylglycine on the one hand and cysteine/homocysteine on the other hand is hypothesized...
  64. ncbi Identification of thioredoxin h-reducible disulphides in proteomes by differential labelling of cysteines: insight into recognition and regulation of proteins in barley seeds by thioredoxin h
    Kenji Maeda
    Department of Chemistry, Carlsberg Laboratory, Copenhagen, Denmark
    Proteomics 5:1634-44. 2005
    ..For the first time, specificity of thioredoxin h for particular disulphide bonds is demonstrated, providing a basis to study structural aspects of the recognition mechanism and regulation of target proteins...
  65. ncbi Thiol-disulfide balance: from the concept of oxidative stress to that of redox regulation
    Pietro Ghezzi
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Antioxid Redox Signal 7:964-72. 2005
    ..This review discusses the importance of protein oxidation in redox regulation in view of the recent data originating from the application of redox proteomics to identify redox-sensitive targets...
  66. pmc Pink-eyed dilution protein modulates arsenic sensitivity and intracellular glutathione metabolism
    Liliana Staleva
    The Ronald O Perelman Department of Dermatology, New York University School of Medicine, New York, New York 10016, USA
    Mol Biol Cell 13:4206-20. 2002
    ..Our data demonstrate that the pink-eyed dilution protein increases cellular sensitivity to arsenicals and other metalloids and can modulate intracellular glutathione metabolism...
  67. ncbi Isotope-coded affinity tag (ICAT) approach to redox proteomics: identification and quantitation of oxidant-sensitive cysteine thiols in complex protein mixtures
    Mahadevan Sethuraman
    Vascular Biology Unit, Cardiovascular Proteomics Center, and Mass Spectrometry Resource, Boston University School of Medicine, Boston, MA 02118, USA
    J Proteome Res 3:1228-33. 2004
    ....
  68. ncbi Evidence that the heme regulatory motifs in heme oxygenase-2 serve as a thiol/disulfide redox switch regulating heme binding
    Li Yi
    Department of Biochemistry, University of Nebraska, Lincoln, Nebraska 68588 0664, USA
    J Biol Chem 282:21056-67. 2007
    ....
  69. ncbi Mucoadhesive thiolated chitosans as platforms for oral controlled drug delivery: synthesis and in vitro evaluation
    Marta Roldo
    Institute of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Vienna, Austria
    Eur J Pharm Biopharm 57:115-21. 2004
    ..These results contribute to the development of new delivery systems exhibiting improved mucoadhesive properties...
  70. pmc Protein thiol modifications visualized in vivo
    Lars I Leichert
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA
    PLoS Biol 2:e333. 2004
    ..Remarkably, a number of these proteins were previously or are now shown to be redox regulated...
  71. ncbi CGFS-type monothiol glutaredoxins from the cyanobacterium Synechocystis PCC6803 and other evolutionary distant model organisms possess a glutathione-ligated [2Fe-2S] cluster
    Antoine Picciocchi
    CEA, iBiTec S, SBIGeM, LBI, Bat 142 CEA Saclay, F 91191 Gif sur Yvette Cedex, France
    Biochemistry 46:15018-26. 2007
    ..In light of these results, the involvement of these enzymes in the sensing of iron and/or the biogenesis and transfer of Fe-S cluster is discussed...
  72. doi Cholesterylestertransfer protein inhibition and endothelial function in type II hyperlipidemia
    Frank Hermann
    University Hospital Zurich, Zurich, Switzerland
    Thromb Res 123:460-5. 2009
    ....
  73. pmc Profiling protein thiol oxidation in tumor cells using sulfenic acid-specific antibodies
    Young Ho Seo
    Life Sciences Institute and Department of Chemistry, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Proc Natl Acad Sci U S A 106:16163-8. 2009
    ....
  74. pmc The cataract-associated R14C mutant of human gamma D-crystallin shows a variety of intermolecular disulfide cross-links: a Raman spectroscopic study
    Ajay Pande
    Department of Chemistry, Life Sciences Research Building, University at Albany, State University of New York, Albany, New York 12222, USA
    Biochemistry 48:4937-45. 2009
    ....
  75. ncbi Changes in thiol content and expression of glutathione redox system genes in the hippocampus and cerebellum in Alzheimer's disease
    M Y Aksenov
    Sanders-Brown Center on Aging, University of Kentucky, 101 Sanders-Brown Building, 800 South Limestone, Lexington, KY 40536-0230, USA
    Neurosci Lett 302:141-5. 2001
    ..This study suggests that protective antioxidant gene responses are insufficient to counteract the increased oxidative damage of proteins in a vulnerable region of the AD brain...
  76. pmc Biochemical characterization of cholesteryl ester transfer protein inhibitors
    Mollie Ranalletta
    Merck Research Laboratories, Rahway, NJ 07065, USA
    J Lipid Res 51:2739-52. 2010
    ..Each CETP inhibitor induced tight binding of CETP to HDL, indicating that these inhibitors promote the formation of a complex between CETP and HDL, resulting in inhibition of CETP activity...
  77. ncbi A modular cross-linking approach for exploring protein interactions
    Michelle Trester-Zedlitz
    Laboratories of Synthetic Protein Chemistry, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Am Chem Soc 125:2416-25. 2003
    ..This integrated approach has been applied to the study of cross-linking between the components of the heterodimeric protein complex negative cofactor 2...
  78. ncbi Protein thiol oxidation in health and disease: techniques for measuring disulfides and related modifications in complex protein mixtures
    Philip Eaton
    Department of Cardiology, Cardiovascular Division, The Rayne Institute, St Thomas Hospital, King s College London, London SE1 7EH, UK
    Free Radic Biol Med 40:1889-99. 2006
    ....
  79. pmc Dalcetrapib: no off-target toxicity on blood pressure or on genes related to the renin-angiotensin-aldosterone system in rats
    E S G Stroes
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Br J Pharmacol 158:1763-70. 2009
    ..The effects of dalcetrapib (RO4607381/JTT-705) and torcetrapib on haemodynamics and the renin-angiotensin-aldosterone system (RAAS) were therefore assessed in a rat model...
  80. ncbi Transcriptional regulation via cysteine thiol modification: a novel molecular strategy for chemoprevention and cytoprotection
    Hye Kyung Na
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul, South Korea
    Mol Carcinog 45:368-80. 2006
    ....
  81. doi Endothelial function and aminothiol biomarkers of oxidative stress in healthy adults
    Salman Ashfaq
    Division of Cardiology, University of Kansas School of Medicine, Wichita, USA
    Hypertension 52:80-5. 2008
    ....
  82. doi Fluorescence imaging of cellular glutathione using a latent rhodamine
    Marcos M Pires
    Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907 2084, USA
    Org Lett 10:837-40. 2008
    ..Importantly, RhoSS was demonstrated to respond to changing levels of glutathione in cells. This compound represents a class of rationally designed latent fluorophores with exciting potential for monitoring cellular thiols...
  83. doi Long-term effects of oxidative stress in volleyball players
    J Martinovic
    Faculty of Pharmacy, University of Belgrade, Institute of Medical Biochemistry, Belgrade, Serbia
    Int J Sports Med 30:851-6. 2009
    ..042). The significantly lower superoxide anion was found between Group 3 and Group 1 (377+/-187 vs. 1183+/-905; p=0.001). Oxidative stress status parameters adequately discriminated 68.5% of athletes with different training experience...
  84. pmc A novel role for cytochrome c: Efficient catalysis of S-nitrosothiol formation
    Swati Basu
    Department of Physics, Wake Forest University, Winston Salem, NC 27109, USA
    Free Radic Biol Med 48:255-63. 2010
    ....
  85. pmc Identification of an unintended consequence of Nrf2-directed cytoprotection against a key tobacco carcinogen plus a counteracting chemopreventive intervention
    Joseph D Paonessa
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 71:3904-11. 2011
    ..Thus, CPDT exemplifies a counteracting solution to the dilemma posed by Nrf2...
  86. ncbi Oxidative stress in cataractogenesis
    Sonja Cekic
    Eye Clinic, Clinic Centre Nis, Bulevar dr Zorana Đinđića 48, 18000 Nis, Serbia
    Bosn J Basic Med Sci 10:265-9. 2010
    ....
  87. pmc 5,6-Dihydrocyclopenta[c][1,2]-dithiole-3(4H)-thione is a promising cancer chemopreventive agent in the urinary bladder
    Joseph D Paonessa
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Chem Biol Interact 180:119-26. 2009
    ..In conclusion, CPDT potently and preferentially induces Phase 2 enzymes in the bladder epithelium and Nrf2 is its key mediator...
  88. pmc The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability
    M Conrad
    Institute of Clinical Molecular Biology and Tumour Genetics, GSF Research Centre for Environment and Health, Munich, Germany
    Mol Cell Biol 25:7637-44. 2005
    ..We conclude that nPHGPx, by acting as a protein thiol peroxidase in vivo, contributes to the structural stability of sperm chromatin...
  89. doi Kinetic and thermodynamic aspects of cellular thiol-disulfide redox regulation
    Kristine Steen Jensen
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Antioxid Redox Signal 11:1047-58. 2009
    ..This is accomplished by enzymes, such as the oxidoreductases, that direct reactions in thermodynamically favorable directions by decreasing the activation energy barrier...
  90. ncbi GEA3162, a nitric oxide-releasing agent, activates non-store-operated Ca2+ entry and inhibits store-operated Ca2+ entry pathways in neutrophils through thiol oxidation
    Mei Feng Hsu
    Department of Biochemistry, School of Medicine, China Medical University, Taichung, Taiwan, Republic of China
    Eur J Pharmacol 535:43-52. 2006
    ..The dual effects of GEA3162 on the regulation of the external Ca2+ entry are mainly through the thiol modification of target protein(s) residing on the outside of the plasma membrane...
  91. ncbi Bound homocysteine, cysteine, and cysteinylglycine distribution between albumin and globulins
    Glen L Hortin
    Department of Laboratory Medicine, Warren Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Chem 52:2258-64. 2006
    ..Major portions of homocysteine (Hcy), cysteine (Cys), cysteinylglycine (CysGly), and glutathione in serum are covalently bound to proteins via disulfides. Albumin has been considered the dominant binding protein...
  92. pmc Mucosal sulfhydryl compounds evaluation by in vivo electron spin resonance spectroscopy in mice with experimental colitis
    H Togashi
    Second Department of Internal Medicine, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Gut 52:1291-6. 2003
    ..A decrease in colonic mucosal SH compounds affects the redox status of the mucosa, resulting in vulnerability to further attacks. Therefore, there is a strong need for in vivo evaluation of SH compounds in the colonic mucosa...
  93. ncbi Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling
    Sue Goo Rhee
    Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 38:1543-52. 2005
    ..This reversible overoxidation may represent an adaptation unique to eukaryotic cells that accommodates the intracellular messenger function of H(2)O(2), but experimental validation of such speculation is yet to come...
  94. ncbi Effect of different mouthrinses on morning breath
    D van Steenberghe
    Department of Periodontology, Oral Pathology and Maxillo-Facial Surgery, Faculty of Medicine, Catholic University of Leuven, Belgium
    J Periodontol 72:1183-91. 2001
    ..CHX-Alc and CHX-CPC-Zn mouthrinses result in a significant reduction of the microbial load of tongue and saliva...
  95. doi Suitability of boron carriers for BNCT: accumulation of boron in malignant and normal liver cells after treatment with BPA, BSH and BA
    F I Chou
    Nuclear Science and Technology Development Center, National Tsing Hua University, Taiwan, ROC
    Appl Radiat Isot 67:S105-8. 2009
    ..BSH had higher retention in liver but low level in pancreas and spleen appears to be a better candidate BNCT drug for hepatoma. These preliminary results provide useful information on future application of BNCT for hepatoma...
  96. doi Measuring mitochondrial protein thiol redox state
    Raquel Requejo
    Medical Research Council Mitochondrial Biology Unit, Wellcome Trust MRC Building, Cambridge, UK
    Methods Enzymol 474:123-47. 2010
    ..Here we outline some of the approaches that can be used to accomplish these goals and thereby infer the multiple roles of mammalian mitochondrial protein thiols in antioxidant defense and redox signaling...
  97. pmc Quantification of oxidative posttranslational modifications of cysteine thiols of p21ras associated with redox modulation of activity using isotope-coded affinity tags and mass spectrometry
    Mahadevan Sethuraman
    Vascular Biology Unit, Boston University School of Medicine, Boston, MA 02118, USA
    Free Radic Biol Med 42:823-9. 2007
    ..The quantitative changes in thiol modification caused by GSSG associated with increased activity demonstrate the potential importance of redox modulation of p21ras...
  98. doi Positive and negative feedback regulatory loops of thiol-oxidative stress response mediated by an unstable isoform of sigmaR in actinomycetes
    Min Sik Kim
    Laboratory of Molecular Microbiology, School of Biological Sciences and Institute of Microbiology, Seoul National University, Seoul, Korea
    Mol Microbiol 73:815-25. 2009
    ..We observed that sigH gene, the sigR orthologue in Mycobacterium smegmatis, produces an unstable larger isoform of sigma(H) upon induction by thiol-oxidative stress...
  99. ncbi Nile Red-adsorbed gold nanoparticle matrixes for determining aminothiols through surface-assisted laser desorption/ionization mass spectrometry
    Yu Fen Huang
    Department of Chemistry, National Taiwan University, 1, Section 4, Roosevelt Road, Taipei, Taiwan
    Anal Chem 78:1485-93. 2006
    ..We validated the applicability of our method through the analyses of GSH in red blood cells and of Cys in plasma; we believe that this approach has great potential for diagnosis...
  100. doi Quantification and identification of mitochondrial proteins containing vicinal dithiols
    Raquel Requejo
    MRC Mitochondrial Biology Unit, Cambridge, UK
    Arch Biochem Biophys 504:228-35. 2010
    ..These findings are consistent with roles for mitochondrial vicinal dithiol proteins in antioxidant defence and redox signalling and these methodologies will enable these roles to be explored...
  101. ncbi Role of protein -SH groups in redox homeostasis--the erythrocyte as a model system
    P Di Simplicio
    Department of Environmental Biology, University of Siena, Via Mattioli 4, Siena, 53100, Italy
    Arch Biochem Biophys 355:145-52. 1998
    ..Species with relatively high PSH reactivity and glucose 6-phosphate dehydrogenase activity, such as the rat, therefore had a higher antioxidant capacity than species (calf) in which these parameters were relatively low...

Research Grants126 found, 100 shown here

  1. Chemical Synthesis of Beta Manno-and Rhamnopyranosides
    David Crich; Fiscal Year: 2005
    ..Accordingly, it is necessary that any truly valuable method be demonstrated to be readily transferable between the two phases. ..
  2. CHEMICAL SYNTESIS OF BETA MANNO- AND RHAMNOPYRANOSIDES
    David Crich; Fiscal Year: 2001
    ....
  3. Methods and Mechanisms in Carbohydrate Chemistry
    David Crich; Fiscal Year: 2003
    ..It is hoped that an enhanced understanding of the poor reactivity of these species will enable the development of protecting groups and conditions to circumvent it. ..
  4. Chemical Synthesis of Beta-Manno and Rehamnopyranosides
    David Crich; Fiscal Year: 2007
    ....
  5. Methods and Mechanisms in Carbohydrate Chemistry
    David Crich; Fiscal Year: 2007
    ....
  6. Thioredoxin-2 protection against mitochondrial oxidative toxicity
    Dean P Jones; Fiscal Year: 2011
    ..This is of considerable importance because therapeutic agents which eliminate reactive species could also disrupt normal signaling. ..
  7. Thioredoxin-2 protection against mitochondrial oxidative toxicity
    Dean P Jones; Fiscal Year: 2010
    ..This is of considerable importance because therapeutic agents which eliminate reactive species could also disrupt normal signaling. ..
  8. A metabolomic model of aging in the common marmoset
    DANIEL EDWARD LEE PROMISLOW; Fiscal Year: 2010
    ..The acquired knowledge has the potential to explain causes of variation in traits of aging within individuals and also differences in aging among individuals in human populations. ..
  9. Nuclear and Cytoplasmic Redox in Oxidative Stress
    Dean P Jones; Fiscal Year: 2010
    ....
  10. Metabolic effects of chemical interactions in toxicity
    Dean Jones; Fiscal Year: 2005
    ....
  11. MITOCHONDRIA IN CHEMICAL-INDUCED APOPTOSIS
    Dean Jones; Fiscal Year: 2007
    ..Aims 1 and 2 will substantially add to basic knowledge of human mtTrx and Aims 3 and 4 will define whether mtTrx has a central function in protection against chemical-induced toxicity. ..
  12. Nuclear and Cytoplasmic Redox in Oxidative Stress
    Dean Jones; Fiscal Year: 2007
    ....
  13. Nuclear and Cytoplasmic Redox in Oxidative Stress
    Dean Jones; Fiscal Year: 2009
    ....
  14. Nuclear and Cytoplasmic Redox in Oxidative Stress
    Dean Jones; Fiscal Year: 2005
    ....
  15. MITOCHONDRIA IN CHEMICAL-INDUCED APOPTOSIS
    Dean Jones; Fiscal Year: 2001
    ..These studies will clarify the role of mitochondria in chemical-induced cell death and provide important new information concerning the mechanistic basis for apoptotic cell death induced by mitochondrial toxicants. ..
  16. Metabolic analysis in human sulfur amino acid deficiency
    Dean Jones; Fiscal Year: 2005
    ..g., 300 samples/day with a flow cell), results will show whether this approach could be useful for nutritional assessment of complex metabolic effects of SAA intake. ..
  17. PP2A-Like Constitutive ERK/MAPK Phosphatase in Brain
    Timothy Foley; Fiscal Year: 2003
    ....
  18. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
    ..The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease. ..
  19. Structural Biology of the S. elongatus Circadian Clock
    Martin Egli; Fiscal Year: 2010
    ....
  20. Pilot-Scale Libraries for High-throughput Screening
    AMOS SMITH; Fiscal Year: 2007
    ....
  21. SYNTHESIS OF PHYLLANTHOSIDE RELATED ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 1991
    ..Once such features are identified, the design of new and possibly more effective antitumor drugs should be feasible...
  22. Design and Synthesis of HIV-1 Protease Inhibitors
    AMOS SMITH; Fiscal Year: 2004
    ....
  23. METABOLISM AND TOXICITY OF HYDROQUINONE-THIOETHERS
    Serrine Lau; Fiscal Year: 2003
    ..The overall goals of this aim are to characterize the Eker animal model in which the effects of environmental influences (chemical exposure) on a genetic predisposition to cancer are determined. ..