sulfhydryl compounds

Summary

Summary: Compounds containing the -SH radical.

Top Publications

  1. ncbi Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
    F Q Schafer
    Free Radical Research Institute and ESR Facility, The University of Iowa, Iowa City, IA 52242 1101, USA
    Free Radic Biol Med 30:1191-212. 2001
  2. ncbi Protein S-nitrosylation: purview and parameters
    Douglas T Hess
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Mol Cell Biol 6:150-66. 2005
  3. ncbi Thiol chemistry and specificity in redox signaling
    Christine C Winterbourn
    Free Radical Research Group and the National Research Centre for Growth and Development, Department of Pathology, University of Otago, Christchurch, New Zealand
    Free Radic Biol Med 45:549-61. 2008
  4. ncbi Disulfide bonds as switches for protein function
    Philip J Hogg
    Centre for Vascular Research, University of New South Wales, and Department of Haematology, Prince of Wales Hospital, NSW, Australia
    Trends Biochem Sci 28:210-4. 2003
  5. pmc Generating disulfides enzymatically: reaction products and electron acceptors of the endoplasmic reticulum thiol oxidase Ero1p
    Einav Gross
    Department of Structural Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 103:299-304. 2006
  6. ncbi Mechanisms of reversible protein glutathionylation in redox signaling and oxidative stress
    MOLLY M GALLOGLY
    Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, and the Louis Stokes Cleveland Veterans Affairs Medical Research Center, Cleveland, OH 44106 4965, United States
    Curr Opin Pharmacol 7:381-91. 2007
  7. ncbi Cellular glutathione and thiols metabolism
    Dale A Dickinson
    Department of Environmental Health Sciences, Center for Free Radical Biology, School of Public Health, University of Alabama at Birmingham, 1530 3rd Avenue S, RPHB 317, Birmingham, AL 35294 0022, USA
    Biochem Pharmacol 64:1019-26. 2002
  8. pmc Quantifying the global cellular thiol-disulfide status
    Rosa E Hansen
    Department of Biology, University of Copenhagen, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    Proc Natl Acad Sci U S A 106:422-7. 2009
  9. ncbi Molecular mechanisms and potential clinical significance of S-glutathionylation
    Isabella Dalle-Donne
    Department of Biology, University of Milan, Milan, Italy
    Antioxid Redox Signal 10:445-73. 2008
  10. ncbi Ratiometric detection of mitochondrial thiols with a two-photon fluorescent probe
    Chang Su Lim
    Department of Chemistry, Korea University, 1 Anamdong, Seoul 136 701, Korea
    J Am Chem Soc 133:11132-5. 2011

Research Grants

Detail Information

Publications296 found, 100 shown here

  1. ncbi Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
    F Q Schafer
    Free Radical Research Institute and ESR Facility, The University of Iowa, Iowa City, IA 52242 1101, USA
    Free Radic Biol Med 30:1191-212. 2001
    ..These are the first steps toward a new quantitative biology, which hopefully will provide a rationale and understanding of the cellular mechanisms associated with cell growth and development, signaling, and reductive or oxidative stress...
  2. ncbi Protein S-nitrosylation: purview and parameters
    Douglas T Hess
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Mol Cell Biol 6:150-66. 2005
    ..S-nitrosylation thereby conveys a large part of the ubiquitous influence of nitric oxide (NO) on cellular signal transduction, and provides a mechanism for redox-based physiological regulation...
  3. ncbi Thiol chemistry and specificity in redox signaling
    Christine C Winterbourn
    Free Radical Research Group and the National Research Centre for Growth and Development, Department of Pathology, University of Otago, Christchurch, New Zealand
    Free Radic Biol Med 45:549-61. 2008
    ..We discuss areas where observations in cell systems can be rationalized with the reactivity of specific oxidants and where further work is needed to understand the mechanisms involved...
  4. ncbi Disulfide bonds as switches for protein function
    Philip J Hogg
    Centre for Vascular Research, University of New South Wales, and Department of Haematology, Prince of Wales Hospital, NSW, Australia
    Trends Biochem Sci 28:210-4. 2003
    ..The function of some secreted soluble proteins and cell-surface receptors is controlled by cleavage of one or more of their disulfide bonds; this cleavage is mediated by catalysts or facilitators that are specific for their substrate...
  5. pmc Generating disulfides enzymatically: reaction products and electron acceptors of the endoplasmic reticulum thiol oxidase Ero1p
    Einav Gross
    Department of Structural Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 103:299-304. 2006
    ..These findings provide insight into mechanisms for regenerating oxidized Ero1p and maintaining disulfide bond formation under anaerobic conditions in the endoplasmic reticulum...
  6. ncbi Mechanisms of reversible protein glutathionylation in redox signaling and oxidative stress
    MOLLY M GALLOGLY
    Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, and the Louis Stokes Cleveland Veterans Affairs Medical Research Center, Cleveland, OH 44106 4965, United States
    Curr Opin Pharmacol 7:381-91. 2007
    ..Accordingly, this review focuses primarily on mechanisms of catalysis in mammalian systems...
  7. ncbi Cellular glutathione and thiols metabolism
    Dale A Dickinson
    Department of Environmental Health Sciences, Center for Free Radical Biology, School of Public Health, University of Alabama at Birmingham, 1530 3rd Avenue S, RPHB 317, Birmingham, AL 35294 0022, USA
    Biochem Pharmacol 64:1019-26. 2002
    ....
  8. pmc Quantifying the global cellular thiol-disulfide status
    Rosa E Hansen
    Department of Biology, University of Copenhagen, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    Proc Natl Acad Sci U S A 106:422-7. 2009
    ..Accordingly, protein thiols are likely to be directly involved in the cellular defense against oxidative stress...
  9. ncbi Molecular mechanisms and potential clinical significance of S-glutathionylation
    Isabella Dalle-Donne
    Department of Biology, University of Milan, Milan, Italy
    Antioxid Redox Signal 10:445-73. 2008
    ..Recently, specific PSSG have been identified in the inferior parietal lobule in Alzheimer's disease. However, much investigation is needed to clarify the actual involvement of protein S-glutathionylation in many human diseases...
  10. ncbi Ratiometric detection of mitochondrial thiols with a two-photon fluorescent probe
    Chang Su Lim
    Department of Chemistry, Korea University, 1 Anamdong, Seoul 136 701, Korea
    J Am Chem Soc 133:11132-5. 2011
    ....
  11. ncbi Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide
    C C Winterbourn
    Department of Pathology, Christchurch School of Medicine, New Zealand
    Free Radic Biol Med 27:322-8. 1999
    ..Due to the complexity of the chain reaction, no study so far has been able to obtain accurate values and we consider the best estimates to be in the 30 to 1000 M(-1) s(-1) range...
  12. ncbi S-glutathionylation in protein redox regulation
    Isabella Dalle-Donne
    Department of Biology, University of Milan, I 20133 Milan, Italy
    Free Radic Biol Med 43:883-98. 2007
    ..In this review, we describe recent breakthroughs in our understanding of the potential role of protein S-glutathionylation in the redox regulation of signal transduction...
  13. ncbi Cysteinylation and homocysteinylation of plasma protein thiols during ageing of healthy human beings
    R Rossi
    Department of Evolutionary Biology, University of Siena, Siena, Italy
    J Cell Mol Med 13:3131-40. 2009
    ..The drop in the plasma level of protein sulphydryl groups suggests depletion and/or impairment of the antioxidant capacity of plasma, likely related to an alteration of the delicate balance between the different redox forms of thiols...
  14. ncbi Redox modifications of protein-thiols: emerging roles in cell signaling
    Saibal Biswas
    Department of Biochemistry, Dr Ambedkar College, Nagpur, Maharashtra State, India
    Biochem Pharmacol 71:551-64. 2006
    ....
  15. pmc Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport
    Eric J Niesor
    Pharmaceuticals Division, F Hoffmann La Roche Ltd, Basel, Switzerland
    J Lipid Res 51:3443-54. 2010
    ..These data suggest that modulation of CETP activity by dalcetrapib does not inhibit CETP-induced pre-β-HDL formation, which may be required to increase reverse cholesterol transport...
  16. pmc A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury
    Tracy A Prime
    MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, United Kingdom
    Proc Natl Acad Sci U S A 106:10764-9. 2009
    ..These results support the idea that selectively targeting NO(*) donors to mitochondria is an effective strategy to reversibly modulate respiration and to protect mitochondria against ischemia-reperfusion injury...
  17. ncbi Quick measurement of protein sulfhydryls with Ellman's reagent and with 4,4'-dithiodipyridine
    Christian K Riener
    Institute of Biophysics, J Kepler University, Altenberger Str 69, A 4040 Linz, Austria
    Anal Bioanal Chem 373:266-76. 2002
    ..Electronic supplementary material to this paper can be obtained by using the Springer Link server located at http://dx.doi.org/10.1007/s00216-002-1347-2...
  18. ncbi Thiolated polymers--thiomers: development and in vitro evaluation of chitosan-thioglycolic acid conjugates
    C E Kast
    Institute of Pharmaceutical Technology and Biopharmaceutics, Center of Pharmacy, University of Vienna, Austria
    Biomaterials 22:2345-52. 2001
    ..According to these results. chitosan-TGA conjugates represent a promising tool for the development of mucoadhesive drug delivery systems...
  19. pmc H2S signals through protein S-sulfhydration
    Asif K Mustafa
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Sci Signal 2:ra72. 2009
    ..Sulfhydration augments GAPDH activity and enhances actin polymerization. Sulfhydration thus appears to be a physiologic posttranslational modification for proteins...
  20. ncbi The disulfide proteome and other reactive cysteine proteomes: analysis and functional significance
    Marika Lindahl
    Instituto de Bioquimica Vegetal y Fotosintesis, Consejo Superior de Investigaciones Científicas Universidad de Sevilla, Centro de Investigaciones Cientificas Isla de la Cartuja, Seville, Spain
    Antioxid Redox Signal 14:2581-642. 2011
    ..Thus, combined with biochemistry and genetics, disulfide proteomics has a significant potential to contribute to new discoveries on redox regulation and signaling...
  21. ncbi Hepatocyte-targeting single galactose-appended naphthalimide: a tool for intracellular thiol imaging in vivo
    Min Hee Lee
    Department of Chemistry, Korea University, Seoul, 136 701, Korea
    J Am Chem Soc 134:1316-22. 2012
    ....
  22. ncbi Redox state of glutathione in human plasma
    D P Jones
    Department of Biochemistry, Atlanta, GA, USA
    Free Radic Biol Med 28:625-35. 2000
    ..These results suggest that E(h) values for GSSG/2GSH and CySS-mono-Gly/(Cys. CysGly) may provide useful means to quantitatively express the oxidant/antioxidant balance in clinical and epidemiologic studies...
  23. ncbi Albumin-bound low molecular weight thiols analysis in plasma and carotid plaques by CE
    Angelo Zinellu
    Dept Biomedical Sciences, University of Sassari, Sassari, Italy
    J Sep Sci 33:126-31. 2010
    ..Due to the elevated sensitivity (LOD of 0.3 pM for all thiols), also low molecular weight thiols bound to albumin filtered in tissues could be quantified...
  24. ncbi Thiol metabolism play significant role during cadmium detoxification by Ceratophyllum demersum L
    Seema Mishra
    Ecotoxicology and Bioremediation Group, National Botanical Research Institute, Rana Pratap Marg, Lucknow, Uttar Pradesh, India
    Bioresour Technol 100:2155-61. 2009
    ..In conclusion, under Cd stress, plants adapted to a new metabolic equilibrium of thiols through coordinated synthesis and consumption to combat Cd toxicity and to accumulate it...
  25. pmc Thiol-based redox switches in eukaryotic proteins
    Nicolas Brandes
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Antioxid Redox Signal 11:997-1014. 2009
    ..Finally, we introduce the redox-sensitive protein tyrosine phosphatase PTP1B to illustrate that reversibility is one of the fundamental aspects of redox-regulation...
  26. ncbi Allosteric disulfide bonds
    Bryan Schmidt
    Centre for Vascular Research, University of New South Wales and Department of Haematology, Prince of Wales Hospital, Sydney, New South Wales 2052, Australia
    Biochemistry 45:7429-33. 2006
    ..We suggest that the -RHStaple configuration is a hallmark of allosteric disulfides. About 1 in 15 of all structurally determined disulfides is a potential allosteric bond...
  27. ncbi Is raising HDL a futile strategy for atheroprotection?
    Tisha Joy
    Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada, N6A 5K8
    Nat Rev Drug Discov 7:143-55. 2008
    ..In this article, we review the complexity of HDL metabolism, discuss clinical-trial data for HDL-raising agents, including possible reasons for the failure of torcetrapib, and consider the potential for future HDL-based therapies...
  28. ncbi The high reactivity of peroxiredoxin 2 with H(2)O(2) is not reflected in its reaction with other oxidants and thiol reagents
    Alexander V Peskin
    Free Radical Research Group, Department of Pathology, University of Otago, P O Box 4345, Christchurch, New Zealand
    J Biol Chem 282:11885-92. 2007
    ..These results demonstrate that peroxiredoxin 2 has a tertiary structure that facilitates reaction of the active site thiol with hydrogen peroxide while restricting its reactivity with other thiol reagents...
  29. ncbi Palladacycles catalyse the oxidation of critical thiols of the mitochondrial membrane proteins and lead to mitochondrial permeabilization and cytochrome c release associated with apoptosis
    Debora P Santana
    Centro Interdisciplinar de Investigação Bioquímica CIIB, Universidade de Mogi das Cruzes UMC, Av Dr Cândido Xavier de Almeida e Souza, 200 Mogi das Cruzes, Sao Paulo, Brazil
    Biochem J 417:247-56. 2009
    ..Besides the contribution to clarify the pro-apoptotic mechanism of PdC, this study shows that the catalysis of specific protein thiol cross-linkage is enough to induce mitochondrial permeabilization and cytochrome c release...
  30. ncbi Elaboration and characterization of thiolated chitosan-coated acrylic nanoparticles
    Irene Bravo-Osuna
    Laboratoire de Physicochimie, Pharmacotechnie et Biopharmacie, UMR CNRS 8612 Université Paris XI, Faculte de Pharmacie, 5, rue J B Clement, 92296 Chatenay Malabry, France
    Int J Pharm 316:170-5. 2006
    ..This new system, combining both the advantages of thiolated polymers and colloidal particles can be proposed as an original drug carrier system for mucosal delivery of biotechnology products...
  31. ncbi CGFS-type monothiol glutaredoxins from the cyanobacterium Synechocystis PCC6803 and other evolutionary distant model organisms possess a glutathione-ligated [2Fe-2S] cluster
    Antoine Picciocchi
    CEA, iBiTec S, SBIGeM, LBI, Bat 142 CEA Saclay, F 91191 Gif sur Yvette Cedex, France
    Biochemistry 46:15018-26. 2007
    ..In light of these results, the involvement of these enzymes in the sensing of iron and/or the biogenesis and transfer of Fe-S cluster is discussed...
  32. ncbi Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery
    Lichen Yin
    State Key Laboratory of Genetic Engineering, Department of Pharmaceutical Sciences, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, China
    Biomaterials 30:5691-700. 2009
    ..Biocompatibility assessment revealed lack of toxicity of TMC-Cys NP. Therefore, self-assembled nanoparticles between TMC-Cys and protein drugs could be an effective and safe oral delivery system...
  33. pmc Plastidial thioredoxin z interacts with two fructokinase-like proteins in a thiol-dependent manner: evidence for an essential role in chloroplast development in Arabidopsis and Nicotiana benthamiana
    Borjana Arsova
    Max Planck Institute of Molecular Plant Physiology, Golm, Germany
    Plant Cell 22:1498-515. 2010
    ..Taken together, our data strongly suggest an important role for TRX z and both FLNs in the regulation of PEP-dependent transcription in chloroplasts...
  34. pmc Quantifying changes in the thiol redox proteome upon oxidative stress in vivo
    Lars I Leichert
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 North University, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 105:8197-202. 2008
    ..These experiments illustrate that OxICAT, which can be used in a variety of different cell types and organisms, is a powerful tool to identify, quantify, and monitor oxidative thiol modifications in vivo...
  35. ncbi Nitric oxide and thiol groups
    B Gaston
    University of Virginia Health System, Box 386, Charlottesville, VA 22908, USA
    Biochim Biophys Acta 1411:323-33. 1999
    ..These reactions are promising targets for the development of new medical therapies...
  36. pmc Chloroplast monothiol glutaredoxins as scaffold proteins for the assembly and delivery of [2Fe-2S] clusters
    Sibali Bandyopadhyay
    Department of Chemistry, Centre for Metalloenzyme Studies, University of Georgia, Athens, GA, USA
    EMBO J 27:1122-33. 2008
    ..Alternatively, they may function in the storage and/or delivery of preformed Fe-S clusters or in the regulation of the chloroplastic Fe-S cluster assembly machinery...
  37. ncbi Nitric oxide activates TRP channels by cysteine S-nitrosylation
    Takashi Yoshida
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615 8510, Japan
    Nat Chem Biol 2:596-607. 2006
    ..These findings reveal the structural motif for the NO-sensitive activation gate in TRP channels and indicate that NO sensors are a new functional category of cellular receptors extending over different TRP families...
  38. pmc Bacillithiol is an antioxidant thiol produced in Bacilli
    Gerald L Newton
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, USA
    Nat Chem Biol 5:625-7. 2009
    ..Bacillithiol is the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid and most probably functions as an antioxidant. Bacillithiol, like the structurally similar mycothiol, may serve as a substitute for glutathione...
  39. pmc Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule
    Amy Trott
    Department of Microbiology and Molecular Genetics, University of Texas Medical School, Houston, TX 77030, USA
    Mol Biol Cell 19:1104-12. 2008
    ....
  40. ncbi Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, The Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biochemistry 44:6889-99. 2005
    ..Keap1 is a zinc-thiol protein endowed with a delicate switch controlled by both metal-binding and thiol reactivity...
  41. ncbi Role of ABC transporter MRPA, gamma-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani
    Angana Mukherjee
    School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, India
    J Antimicrob Chemother 59:204-11. 2007
    ..The present work investigates the mechanism of resistance to SAG in parasites isolated from patients who are unresponsive to SAG...
  42. pmc Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
    A T Dinkova-Kostova
    Department of Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:3404-9. 2001
    ..This enhancement correlates with more rapid reactivity of the ortho-hydroxylated derivatives with model sulfhydryl compounds. Proton NMR spectroscopy provides no evidence for increased electrophilicity of the beta-vinyl carbons (the ..
  43. ncbi Cell-surface thiols affect cell entry of disulfide-conjugated peptides
    Soline Aubry
    UPMC Universite Paris 06, UMR 7613, Synthesis, Structure, and Function of Bioactive Molecules, Paris, France
    FASEB J 23:2956-67. 2009
    ....
  44. pmc Mechanistic and kinetic details of catalysis of thiol-disulfide exchange by glutaredoxins and potential mechanisms of regulation
    MOLLY M GALLOGLY
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
    Antioxid Redox Signal 11:1059-81. 2009
    ..Part II presents potential mechanisms for in vivo regulation of Grx activity, providing avenues for future studies...
  45. ncbi The polarization of T(h)1/T(h)2 balance is dependent on the intracellular thiol redox status of macrophages due to the distinctive cytokine production
    Yukie Murata
    Basic Research Laboratories, Ajinomoto Co Inc, 1 1 Suzuki cho, Kawasaki ku, Kawasaki 210 0861, Japan
    Int Immunol 14:201-12. 2002
    ..The findings implicate that the alteration in Mp functions because altered intracellular glutathione may play a relevant role in the pathological progression of inflammation...
  46. pmc Ursodeoxycholic acid prevents selenite-induced oxidative stress and alleviates cataract formation: In vitro and in vivo studies
    Hui Ping Qi
    Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, China
    Mol Vis 18:151-60. 2012
    ..To evaluate the antioxidative and anticataractogenic potential effect of ursodeoxycholic acid (UDCA) on selenite-induced cataract in vitro and in vivo...
  47. pmc PEG hydrogels formed by thiol-ene photo-click chemistry and their effect on the formation and recovery of insulin-secreting cell spheroids
    Chien Chi Lin
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University at Indianapolis, IN 46202, USA
    Biomaterials 32:9685-95. 2011
    ....
  48. pmc Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial
    Zahi A Fayad
    Translational and Molecular Imaging Institute and Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Lancet 378:1547-59. 2011
    ..dal-PLAQUE is the first multicentre study using novel non-invasive multimodality imaging to assess structural and inflammatory indices of atherosclerosis as primary endpoints...
  49. ncbi Substrate-, wavelength-, and time-dependent plasmon-assisted surface catalysis reaction of 4-nitrobenzenethiol dimerizing to p,p'-dimercaptoazobenzene on Au, Ag, and Cu films
    Bin Dong
    Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, P O Box 603 146, Beijing 100190, PR China
    Langmuir 27:10677-82. 2011
    ..Our experimental results revealed that optimal experimental conditions can be rationally chosen to control (accelerate or restrain) this reaction. The experimental results are also confirmed by theoretical calculations...
  50. ncbi Aryl methyl sulfides as substrates for rhodium-catalyzed alkyne carbothiolation: arene functionalization with activating group recycling
    Joel F Hooper
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK
    J Am Chem Soc 134:2906-9. 2012
    ..The utility of the alkenyl sulfide products is also demonstrated in simple carbo- and heterocycle-forming processes. We also provide mechanistic evidence for the course of this new process...
  51. ncbi Evaluation of low molecular mass thiols content in carotid atherosclerotic plaques
    Angelo Zinellu
    Dipartimento di Scienze Biomediche, Universita di Sassari, Italy Istituto Nazionale Biostrutture e Biosistemi, Osilo, Italy
    Clin Biochem 42:796-801. 2009
    ....
  52. ncbi Simple biosensor with high selectivity and sensitivity: thiol-specific biomolecular probing and intracellular imaging by AIE fluorogen on a TLC plate through a thiol-ene click mechanism
    Yang Liu
    Department of Chemistry, Institute of Molecular Functional Materials, The Hong Kong University of Science and Technology HKUST, Clear Water Bay, Kowloon, Hong Kong, China
    Chemistry 16:8433-8. 2010
    ..Clear fluorescence images were taken when living cells were stained by using TPE-MI as a visualization agent, affording a facile fluorescent maker for mapping the distribution of thiol species in cellular systems...
  53. pmc Biosynthetic and iron metabolism is regulated by thiol proteome changes dependent on glutaredoxin-2 and mitochondrial peroxiredoxin-1 in Saccharomyces cerevisiae
    Brian McDonagh
    Department of Biochemistry and Molecular Biology and Córdoba Maimónides Institute for Biomedical Research IMIBIC, University of Cordoba, 14071 Cordoba, Spain
    J Biol Chem 286:15565-76. 2011
    ..Strikingly, requirement of Grx2p for these events places dithiolic Grx2 in the framework of iron metabolism...
  54. ncbi Characterization of natural antimony resistance in Leishmania donovani isolates
    Mukul K Mittal
    Division of Biochemistry, Central Drug Research Institute, Lucknow, India
    Am J Trop Med Hyg 76:681-8. 2007
    ..These results suggest the possible role of thiols and MRPA in antimony resistance in field isolates...
  55. ncbi Thiol/disulfide redox states in signaling and sensing
    Young Mi Go
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Crit Rev Biochem Mol Biol 48:173-81. 2013
    ..Biological responses to cadmium, a widespread environmental agent, are used to illustrate the utility of these advances to the understanding of complex pleiotropic toxicities...
  56. ncbi Expression and activity of sulfate transporters and APS reductase in curly kale in response to sulfate deprivation and re-supply
    Aleksandra Koralewska
    Laboratory of Plant Physiology, University of Groningen, 9750 AA Haren, The Netherlands
    J Plant Physiol 166:168-79. 2009
    ....
  57. ncbi Fluorescent and colorimetric probes for detection of thiols
    Xiaoqiang Chen
    Department of Chemistry and Nano Science BK 21, Ewha Womans University, Seoul 120 750, Korea
    Chem Soc Rev 39:2120-35. 2010
    ....
  58. ncbi A two-photon fluorescent probe for thiols in live cells and tissues
    Jun Han Lee
    Department of Chemistry, Korea University, 1 Anamdong, Seoul, 136 701, Korea
    J Am Chem Soc 132:1216-7. 2010
    ....
  59. ncbi Disulfide exchange in domain 2 of CD4 is required for entry of HIV-1
    Lisa J Matthias
    Centre for Thrombosis and Vascular Research, School of Medical Sciences, University of New South Wales and Department of Haematology, Prince of Wales Hospital, Sydney, NSW 2052, Australia
    Nat Immunol 3:727-32. 2002
    ..These findings indicate that redox changes in CD4 D2 are important for HIV-1 entry and represent a new target for HIV-1 entry inhibitors...
  60. pmc Endothelial function and aminothiol biomarkers of oxidative stress in healthy adults
    Salman Ashfaq
    Division of Cardiology, University of Kansas School of Medicine, Wichita, USA
    Hypertension 52:80-5. 2008
    ....
  61. pmc Modulation of cell surface protein free thiols: a potential novel mechanism of action of the sesquiterpene lactone parthenolide
    Jolanta Skalska
    James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 4:e8115. 2009
    ..Given recent data to suggest that the redox status of extracellular protein thiol groups (i.e. exofacial thiols) effects cell behavior, we hypothesized that redox active anti-cancer agents would modulate exofacial protein thiols...
  62. ncbi Vicinal thiols are required for activation of the αIIbβ3 platelet integrin
    N Manickam
    Division of Hematology, Department of Medicine, The University of Texas Health Science Center, San Antonio, TX, USA
    J Thromb Haemost 9:1207-15. 2011
    ..These thiols provide a mechanism to regulate protein function. We previously found that thiols in both αIIb and β3 of the αIIbβ3 fibrinogen receptor were required for platelet aggregation...
  63. ncbi Thioredoxin targets of the plant chloroplast lumen and their implications for plastid function
    Michael Hall
    Department of Chemistry, Umea3 University, Umea3, Sweden
    Proteomics 10:987-1001. 2010
    ..Our results indicate that redox-controlled reactions in the chloroplast lumen play essential roles in the function of photosystem II and the regulation of adaptation to light intensity...
  64. ncbi Mucoadhesive effect of thiolated PEG stearate and its modified NLC for ocular drug delivery
    Jie Shen
    School of Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China
    J Control Release 137:217-23. 2009
    ..05), compared with the NLC without thiomer modification...
  65. ncbi Thiolated chitosans: development and in vitro evaluation of an oral tobramycin sulphate delivery system
    Juliane Hombach
    Institute of Pharmacy, Leopold Franzens University Innsbruck, Innrain 52, Josef Moller Haus, 6020 Innsbruck, Austria
    Eur J Pharm Sci 33:1-8. 2008
    ..The developed drug delivery system containing chitosan-NAC and glutathione is a promising tool for oral tobramycin sulphate administration showing improved gastrointestinal uptake and a sustained release...
  66. pmc Vascular effects and safety of dalcetrapib in patients with or at risk of coronary heart disease: the dal-VESSEL randomized clinical trial
    Thomas F Luscher
    Department of Cardiology, Cardiovascular Centre, University of Zurich, 8091 Zurich, Switzerland
    Eur Heart J 33:857-65. 2012
    ..gov number NCT00655538)...
  67. pmc Reaction based fluorescent probes for hydrogen sulfide
    Chunrong Liu
    Department of Chemistry, Washington State University, Pullman, Washington 99164, USA
    Org Lett 14:2184-7. 2012
    ..Other biological thiols such as cysteine and glutathione did not pursue the reaction and therefore did not turn on the fluorescence/consume the substrates. The probes showed good selectivity and sensitivity for hydrogen sulfide...
  68. ncbi A rhodamine-based fluorescent probe containing a Se-N bond for detecting thiols and its application in living cells
    Bo Tang
    Chemical Engineering and Materials Science, Engineering Research Center of Pesticide and Medicine Intermediate Clean Production, College of Chemistry, Ministry of Education, Shandong Normal University, Jinan, People s Republic of China
    J Am Chem Soc 129:11666-7. 2007
  69. pmc Preactivated thiomers as mucoadhesive polymers for drug delivery
    Javed Iqbal
    Department of Pharmaceutical Technology, Leopold Franzens University Innsbruck, Innsbruck, Austria
    Biomaterials 33:1528-35. 2012
    ..Thus, on the basis of achieved results the pre-activated thiomers seem to represent a promising generation of mucoadhesive polymers which are safe to use for prolonged residence time of drug delivery systems to target various mucosa...
  70. ncbi SIN-1 cytotoxicity to PC12 cells is mediated by thiol-sensitive short-lived substances generated through SIN-1 decomposition in culture medium
    Kanako Konishi
    Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, Japan
    Nitric Oxide 20:270-8. 2009
    ..These results suggest that SIN-1 cytotoxicity in PC12 cells is mediated via the generation of cytotoxic substances in the medium during its decomposition...
  71. ncbi Tumor-specific targeting of sodium borocaptate (BSH) to malignant glioma by transferrin-PEG liposomes: a modality for boron neutron capture therapy
    Atsushi Doi
    Department of Neurosurgery, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka 569 8686, Japan
    J Neurooncol 87:287-94. 2008
    ..To improve a drug delivery in BNCT, we devised transferrin-conjugated polyethylene-glycol liposome encapsulating sodium borocaptate (TF-PEG-BSH)...
  72. ncbi Chitosan-graft-6-mercaptonicotinic acid: synthesis, characterization, and biocompatibility
    Gioconda Millotti
    Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold Franzens University, Innrain 52c, Josef Moller Haus, Innsbruck, Austria
    Biomacromolecules 10:3023-7. 2009
    ..The reactivity of thiol groups was in the same range at pH 3 and pH 6.8. According to these results, chitosan-6 mercaptonicotinic acid seems to have some promising features to be used particularly for mucoadhesive formulations...
  73. pmc Direct observation of disulfide isomerization in a single protein
    Jorge Alegre-Cebollada
    Department of Biological Sciences, Columbia University, Northwest Corner Building, 550 West 120 Street, New York, New York 10027, USA
    Nat Chem 3:882-7. 2011
    ..This allowed us to measure, for the first time, the kinetics of disulfide-bond isomerization in a protein...
  74. ncbi Redox proteomics: identification of oxidatively modified proteins
    Pietro Ghezzi
    Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy
    Proteomics 3:1145-53. 2003
    ....
  75. ncbi Different effects of compounds decreasing cholesteryl ester transfer protein activity on lipoprotein metabolism
    Eric J Niesor
    Pharmaceuticals Division, F Hoffmann La Roche Ltd, Basel, Switzerland
    Curr Opin Lipidol 22:288-95. 2011
    ....
  76. ncbi Gastroprotective mechanisms of Citrus lemon (Rutaceae) essential oil and its majority compounds limonene and β-pinene: involvement of heat-shock protein-70, vasoactive intestinal peptide, glutathione, sulfhydryl compounds, nitric oxide and prostaglandin E
    Ariane Leite Rozza
    Morphology Department, Biosciences Institute, Univ Estadual Paulista, Botucatu, SP, Brazil
    Chem Biol Interact 189:82-9. 2011
    ..CL gastroprotective mechanism is involved with PGE₂. PIN did not present gastroprotective activity...
  77. ncbi Anacetrapib and dalcetrapib: two novel cholesteryl ester transfer protein inhibitors
    Marta A Miyares
    Pharmacy Department, Jackson Memorial Hospital, Miami, FL, USA
    Ann Pharmacother 45:84-94. 2011
    ....
  78. pmc Drevogenin D prevents selenite-induced oxidative stress and calpain activation in cultured rat lens
    P G Biju
    Department of Biochemistry, University of Kerala, Kerala, India
    Mol Vis 13:1121-9. 2007
    ..The purpose of the study was to evaluate the role of Drevogenin D, a triterpenoid aglycone, isolated from Dregea volubilis in preventing selenite-induced, calcium-activated, calpain-mediated proteolysis in cultured rat lenses...
  79. pmc Cystic fibrosis transmembrane conductance regulator: using differential reactivity toward channel-permeant and channel-impermeant thiol-reactive probes to test a molecular model for the pore
    Christopher Alexander
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Biochemistry 48:10078-88. 2009
    ..The results provide an initial validation of two, new molecular models for CFTR and suggest that molecular dynamics simulation will be a useful tool for unraveling the structural basis of anion conduction by CFTR...
  80. pmc Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage
    Raquel Requejo
    MRC Mitochondrial Biology Unit, Wellcome Trust MRC Building, Cambridge, UK
    FEBS J 277:1465-80. 2010
    ..Therefore, exposed protein thiols are the dominant free thiol within the cell and may play a critical role in intracellular antioxidant defences against oxidative damage...
  81. ncbi OxyR: a molecular code for redox-related signaling
    Sung Oog Kim
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 109:383-96. 2002
    ....
  82. ncbi Tuning of shell and core characteristics of chitosan-decorated acrylic nanoparticles
    I Bravo-Osuna
    CNRS, UMR CNRS 8612, Faculte de Pharmacie, 5 rue J B Clement, 92296 Chatenay Malabry, France
    Eur J Pharm Sci 30:143-54. 2007
    ..Positive surface charge values were obtained in all cases. In addition, evidences of the presence of thiol groups were obtained (0.03-0.16 x 10(-3)micromol/cm(2) of nanoparticle)...
  83. ncbi A bystander effect observed in boron neutron capture therapy: a study of the induction of mutations in the HPRT locus
    Yuko Kinashi
    Research Reactor Institute, Kyoto University, Osaka, Japan
    Int J Radiat Oncol Biol Phys 68:508-14. 2007
    ..The BSH-containing cells were irradiated with alpha-particles produced by the 10B(n,alpha)7Li reaction, whereas cells without boron were affected only by the 1H(n,gamma)2H and 14N(n,rho)14C reactions...
  84. ncbi Monofunctional gold nanoparticles prepared via a noncovalent-interaction-based solid-phase modification approach
    Xiong Liu
    Nanoscience Technology Center and Department of Chemistry, University of Central Florida, 12424 Research Parkway Suit 400, Orlando, FL 32826, USA
    Small 2:1126-9. 2006
  85. ncbi Thiols in cellular redox signalling and control
    L K Moran
    Unit of Critical Care, The Royal Brompton Hospital, Imperial College School of Medicine. Sydney Street, London, SW3 6NP, UK
    Curr Med Chem 8:763-72. 2001
    ..Particular attention has been paid to the importance of thiols and thiol-containing molecules in these processes...
  86. ncbi S-glutathionylation: from redox regulation of protein functions to human diseases
    Daniela Giustarini
    Department of Neuroscience, University of Siena, Siena, Italy
    J Cell Mol Med 8:201-12. 2004
    ..S-glutathionylated proteins are now actively investigated with reference to problems of biological interest and as possible biomarkers of human diseases associated with oxidative/nitrosative stress...
  87. ncbi Kinetics and mechanism of the reaction of cysteine and hydrogen peroxide in aqueous solution
    Dayong Luo
    Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40506, USA
    J Pharm Sci 94:304-16. 2005
    ..A thorough understanding of the mechanism in aqueous solution will provide valuable background information for current studies aimed at elucidating the influence of such factors on thiol oxidation in solid-state formulations...
  88. ncbi Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis
    Md Firoz Mian
    Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang 790 784, South Korea
    Chem Biol Interact 171:57-66. 2008
    ..From the present results, it is more likely that not cell detachment but the proteolytic cleavage (or inhibition) of FAK is a key modulator as well as a promising indicator of apoptosis in epithelial cells under oxidative stress...
  89. ncbi Glutathione peroxidase, thioredoxin, and membrane protein changes in erythrocytes predict ribavirin-induced anemia
    Ignazio Grattagliano
    Section of Internal Medicine, Department of Internal Medicine and Public Medicine, University of Bari, Bari, Italy
    Clin Pharmacol Ther 78:422-32. 2005
    ..Low erythrocyte membrane protein sulfhydril concentrations are a risk factor for ribavirin-induced anemia. We further studied the role of oxidative stress and erythrocyte membrane alterations in ribavirin-induced anemia...
  90. ncbi Quantification of thiol-containing amino acids linked by disulfides to LDL
    Angelo Zinellu
    University of Sassari, Viale San Pietro 43 B, 07100 Sassari, Italy
    Clin Chem 51:658-60. 2005
  91. ncbi Intracellular targeting of sodium mercaptoundecahydrododecaborate (BSH) to solid tumors by transferrin-PEG liposomes, for boron neutron-capture therapy (BNCT)
    Kazuo Maruyama
    Department of Pharmaceutics, Teikyo University, Sagamiko, Kanagawa 199 0195, Japan
    J Control Release 98:195-207. 2004
    ..These results suggest that BSH-encapsulating TF-PEG liposomes may be useful as a new intracellular targeting carrier in BNCT therapy for cancer...
  92. ncbi Reactive oxygen metabolites and prooxidant status in children with Down's syndrome
    M Carratelli
    Diacron S.r.l, Diagnostic Division, Grosseto, Italy
    Int J Clin Pharmacol Res 21:79-84. 2001
    ..The new test available for measuring reactive oxygen species in serum proved to be reliable and useful as an early marker of tissue damage...
  93. ncbi Oxidoreduction of protein thiols in redox regulation
    P Ghezzi
    Mario Negri Institute, Via Eritrea 62, 20157 Milan, Italy
    Biochem Soc Trans 33:1378-81. 2005
    ..This review discusses the evolution of the concept of redox regulation from that of oxidative stress and the redox state of protein cysteines in different cellular compartments...
  94. ncbi Proteomics of Arabidopsis redox proteins in response to methyl jasmonate
    Sophie Alvarez
    Department of Botany and Zoology, Genetics Institute, The Plant Molecular and Cellular Biology Program, University of Florida, Gainesville, FL 32611, USA
    J Proteomics 73:30-40. 2009
    ..Identification of redox proteins and their cysteine residues involved in the redox regulation allows for a deeper understanding of the jasmonate signaling networks...
  95. ncbi Bioelectronic detector with monoamine oxidase for halitosis monitoring
    T Minamide
    Graduate School of Engineering, Tokai University, Hiratsuka, Japan
    Analyst 130:1490-4. 2005
    ..The output of bio-detector showed behaviour of halitosis level changes in a day such as increasing with passage of time and decreasing after eating...
  96. ncbi Plasma thiols redox status by laser-induced fluorescence capillary electrophoresis
    Ciriaco Carru
    Chair of Clinical Biochemistry, University of Sassari, Viale San Pietro 43 B, I 07100 Sassari, Italy
    Electrophoresis 25:882-9. 2004
    ..Linearity, reproducibility, analytical recovery, and sensitivity were evaluated. The assay was used to measure the thiols redox status in 15 plasma samples from healthy volunteers...
  97. ncbi Analysis of plasma thiols by high-performance liquid chromatography with ultraviolet detection
    E Bald
    Department of Environmental Chemistry, University of Lodz, 163 Pomorska Street, 90 236 Lodz, Poland
    J Chromatogr A 1032:109-15. 2004
    ..The method is linear within the physiological and pathological ranges of thiols and is applied for plasma samples donated by apparently healthy volunteers...
  98. ncbi Age-related influence on thiol, disulfide, and protein-mixed disulfide levels in human plasma
    Daniela Giustarini
    Department of Neuroscience, Pharmacology Unit, University of Siena, Via A Moro 4, I 53100, Siena, Italy
    J Gerontol A Biol Sci Med Sci 61:1030-8. 2006
    ..The occurrence of two distinct regulatory systems for plasmatic pools of glutathione/cysteinylglycine on the one hand and cysteine/homocysteine on the other hand is hypothesized...
  99. ncbi Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: thiomer/GSH systems
    A Bernkop-Schnürch
    Institute of Pharmaceutical Technology and Biopharmaceutics, Center of Pharmacy, University of Vienna, Althanstr 14, A 1090 Vienna, Austria
    J Control Release 93:95-103. 2003
    ....
  100. ncbi Identification of thioredoxin h-reducible disulphides in proteomes by differential labelling of cysteines: insight into recognition and regulation of proteins in barley seeds by thioredoxin h
    Kenji Maeda
    Department of Chemistry, Carlsberg Laboratory, Copenhagen, Denmark
    Proteomics 5:1634-44. 2005
    ..For the first time, specificity of thioredoxin h for particular disulphide bonds is demonstrated, providing a basis to study structural aspects of the recognition mechanism and regulation of target proteins...
  101. ncbi A sensitive method for the quantitative measurement of protein thiol modification in response to oxidative stress
    Aimee Landar
    Department of Pathology, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Free Radic Biol Med 40:459-68. 2006
    ..Thus, we have developed a versatile, cost-effective standard that can be used in proteomic methods to quantitate biotin tags in response to oxidative stress...

Research Grants65

  1. BIOLOGY OF MYOCARDIAL ISCHEMIA
    Mark Entman; Fiscal Year: 1990
    ..of oxidative stress by measuring lipid hydroxy-acids and hydroperoxides as well as the redox of various sulfhydryl compounds (glutathione, protein mixed disulfides) in cardiac lymph and myocardial biopsy samples...
  2. MYLEOPEROXIDASE AND LEUKOCYTE GRANULE COMPONENTS
    EDWIN THOMAS; Fiscal Year: 1992
    ..in H202 production and an oxidant for extracellular reductants such as ascorbate (vitamin C) and sulfhydryl compounds. Oxidation of these reductants by 02-increases H202 production and consumes the reductants so that they can'..
  3. ANTAGONISM OF SELENIUM FUNCTION BY MERCAPTANS
    GERALD COMBS; Fiscal Year: 1990
    ..The results can be expected to yield information relevant to both the mode of action of mercaptans and the metabolic function of Se...
  4. MECHANISM-BASED THERAPEUTICS EXPLOITING TUMOR BIOLOGY
    Francis Sirotnak; Fiscal Year: 1999
    ..The mechanism of activation of lysosomal folyl polyglutamate hydrolase by endogenous reduced sulfhydryl compounds will also be examined...
  5. Metabolic effects of chemical interactions in toxicity
    Dean Jones; Fiscal Year: 2005
    ....
  6. Metabolic analysis in human sulfur amino acid deficiency
    Dean Jones; Fiscal Year: 2005
    ..g., 300 samples/day with a flow cell), results will show whether this approach could be useful for nutritional assessment of complex metabolic effects of SAA intake. ..
  7. PP2A-Like Constitutive ERK/MAPK Phosphatase in Brain
    Timothy Foley; Fiscal Year: 2003
    ....
  8. NOVEL NONINDUCIBLE THYMIDYLATE SYNTHASE INHIBITORS
    Aleem Gangjee; Fiscal Year: 2004
    ....
  9. Third Generation Antiopportunistic Agents
    Aleem Gangjee; Fiscal Year: 2003
    ..Screening against tuberculosis (NIAID) and tumor cells in culture (NCI) is also proposed. ..
  10. Novel, P. jirovecii Specific Antipneumocystis Agents
    Aleem Gangjee; Fiscal Year: 2009
    ..These agents could be used alone or in combination to treat PCP thus providing novel agents against a new target. ..
  11. Pediatric Severe Asthma: Role of Oxidant Stress and Alveolar Macrophage Function
    Anne Fitzpatrick; Fiscal Year: 2009
    ..This proposal will lay the foundation for further studies, and the mechanisms identified may ultimately be targeted in future interventional trials. ..
  12. Dietary Cysteine:Conceptal Response to Oxidative Stress
    Craig Harris; Fiscal Year: 2002
    ....
  13. Novel Single, Dual and Multitargeted Inhibitors of RTKs
    Aleem Gangjee; Fiscal Year: 2007
    ..abstract_text> ..
  14. STRUCTURE BASED ANALOGS AS ANTIOPPORTUNISTIC AGENTS
    Aleem Gangjee; Fiscal Year: 2001
    ..The analogues synthesized will also be submitted for screening against tuberculosis (NIAID) parasitic diseases (WHO) and tumor cells in culture (NCI). ..
  15. Alpha Folate Receptor Mediated GARFTase Inhibitors as Selective Antitumor Agents
    Aleem Gangjee; Fiscal Year: 2010
    ....
  16. Single Agents with Designed Combination Chemotherapy Potential
    Aleem Gangjee; Fiscal Year: 2010
    ..abstract_text> ..
  17. Antitumor Antimitotics That Reverse Tumor Resistance
    Aleem Gangjee; Fiscal Year: 2010
    ..The study will also further define the mechanism of action of the novel series and could afford agents for clinical use. ..
  18. Nanoparticles for Molecular MRI of Atherosclerosis
    Zahi Fayad; Fiscal Year: 2008
    ..These studies will provide the basis for future advances in experimental studies of atherosclerogenesis and new clinical applications of non-invasive, in vivo MR imaging of atherosclerotic lesions. [unreadable] [unreadable] [unreadable]..
  19. Isothiocyanates in the Chemoprevention of Bladder Cancer
    Yuesheng Zhang; Fiscal Year: 2007
    ..Aim 5 will determine the efficacy of an orally administered ITC in inhibiting N-butyl-N- (4-hydroxybutyl)-nitrosamine-induced bladder tumorigenesis in F344 rats. ..
  20. Human Lung Chromium Toxicity: Role of cytochrome b5
    Charles Myers; Fiscal Year: 2007
    ..They will provide a deeper understanding of the mechanisms underlying Cr(VI) toxicity in human lung, and will lead to new insights on the role of b5 in toxicant activation [unreadable] [unreadable]..
  21. Vision Research Infrastructure Development Grant (R24)
    FRANK GIBLIN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  22. SYNTHESIS OF SPONGISTATIN ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 2007
    ..abstract_text> ..
  23. Portable Analyzer for On-site Monitoring of Worker Exposure to Toxic Metals
    Charles Timchalk; Fiscal Year: 2007
    ..Ultimately, the sensor for metal ions will be combined with the sensor for creatinine so that the exposure monitoring can be performed with "spot" urine instead of 24-hr urine. [unreadable] [unreadable] [unreadable]..
  24. CVN-12p1 Chimeras and Combinations for AIDS Microbiocides
    Irwin Chaiken; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  25. Novel Methods for in Vivo Imaging of Tissue Oxygenation
    Periannan Kuppusamy; Fiscal Year: 2008
    ..The technology should offer exciting new opportunities in the field of biomedical imaging of free radicals and oxygen. ..
  26. Biomimetic Studies of NO-binding Respiratory Chain Hemes
    JAMES COLLMAN; Fiscal Year: 2008
    ..An emphasis will be placed on kinetic and mechanistic studies to elucidate the putitive reaction pathways of CcO and NOR. ..
  27. Multifunctional reagents for proteomic analysis
    CHRISTIAN SCHONEICH; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  28. Obesity, Inflammation and Thrombosis: LOOK AHEAD
    Christie M Ballantyne; Fiscal Year: 2010
    ....
  29. Polynuclear Clusters in Nitrogenase-Structure Reactivity
    Dimitri Coucouvanis; Fiscal Year: 2007
    ..abstract_text> ..
  30. PKC Modulators for the Treatment of Alzheimer's disease
    Alan Kozikowski; Fiscal Year: 2008
    ..For the best compounds from Aim 2, perform studies in triple transgenic mice to ascertain effects on Abeta and sAPPalpha levels and plaque formation in vivo. ..
  31. Design and Development of Pharmacotherapies for Treating Stimulant Abuse
    Frank Ivy Carroll; Fiscal Year: 2010
    ..3) To continue on a limited basis our development of selected 3-phenyltropane analogs as second-generation pharmacotherapies to treat cocaine addiction. ..
  32. COCAINE: A STUDY OF THE BIOCHEMICAL MECHANISM OF ACTION
    Frank Carroll; Fiscal Year: 2007
    ..abstract_text> ..
  33. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  34. MOLECULAR BASIS OF HIGH DENSITY LIPOPROTEIN DEFICIENCY
    ERNST SCHAEFER; Fiscal Year: 2009
    ..The results of this work will provide important insight into the contribution of allelic variation in the pathways of HDL metabolism, inflammation, and insulin resistance to the complex phenotype of low HDL-C. ..
  35. Cd2+, Metallothionein and Transcriptional Control of Na+ Glucose Co-Transporter 1
    DAVID PETERING; Fiscal Year: 2009
    ..abstract_text> ..
  36. NOVEL PHARMACOTHERAPY FOR TREATMENT OF COCAINE ADDICTION
    Frank Carroll; Fiscal Year: 2008
    ..abstract_text> ..
  37. NEW SYNTHETIC METHODS FOR ANTICANCER RESEARCH
    LANNY LIEBESKIND; Fiscal Year: 2001
    ..Using cyclobutenedione methodology as a seminal component of each system, metallaquinones and porphyrin quinones are being developed as novel anticancer agents. ..
  38. DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISK
    ERNST SCHAEFER; Fiscal Year: 2003
    ..abstract_text> ..
  39. EPR IMAGING OF TUMOR HETEROGENEITY AND OXYGENATION
    Periannan Kuppusamy; Fiscal Year: 2003
    ..Information obtained from these studies should enable the development and optimization of therapeutic modalities for cancer treatment. ..
  40. POSTTRANSLATIONAL MODIFICATION/STRUCTURE-FUNCTION OF BON
    Erdjan Salih; Fiscal Year: 2003
    ....
  41. MAC 1/LFA 1/P150 95 AND PMN LEUKOCYTE FUNCTION
    Christie Ballantyne; Fiscal Year: 2002
    ..3. Characterize the contribution of each CD11 integrin on the host response to common bacterial and fungal pathogens in vitro and in vivo. ..
  42. MERCURY NEPHROTOXICITY AFTER A REDUCTION OF RENAL MASS
    RUDOLFS ZALUPS; Fiscal Year: 2002
    ..abstract_text> ..
  43. HPLC DETECTION OF RADICAL INTERMEDIATES
    Detcho Stoyanovsky; Fiscal Year: 2002
    ..The method is expected to display several orders of magnitude higher sensitivity than then traditional ESR spin trapping technique and may be a new approach in assays of oxidative stress. ..
  44. MODELING OF MIXED LIGAND THERAPY FOR IRON OVERLOAD
    Robert Hider; Fiscal Year: 2002
    ..We aim to define the principles and potential candidates for optimal mixed ligand therapy for iron overload. ..
  45. OUTER MEMBRANE CYTOCHROMES--TOPOLOGY AND FUNCTION
    Charles Myers; Fiscal Year: 2002
    ..They will also contribute to environmental health by expanding our knowledge on the mechanisms by which manganese, iron, and various heavy metals are mobilized into water supplies. ..
  46. SYNTHESIS OF CHLOROPEPTINS, GP120 CD4 BINDING INHIBITORS
    AMOS SMITH; Fiscal Year: 2001
    ..abstract_text> ..
  47. BIOLOGICAL STUDIES OF PIPERIDINE ANALOGS OF COCAINE
    Alan Kozikowski; Fiscal Year: 2001
    ..4. For compounds meeting set criteria, to further evaluate their behavioral pharmacological profile in animals using intravenous drug self-administration and drug discrimination procedures. ..
  48. CHANNEL-MEDIATED RBC DEHYDRATION IN SICKLE CELL DISEASE
    Alicia Rivera; Fiscal Year: 2003
    ..It is additionally significant, because it will provide the means for the applicant to establish an independent research career and to become competitive for a tenure-track assistant professional position. ..
  49. INTERLEUKIN 5 RECEPTOR RECOGNITION, MIMETICS, ANTAGONISM
    Irwin Chaiken; Fiscal Year: 2004
    ..And it will yield antagonist strategies which could lead to molecular tools for therapeutic intervention in asthma and other allergic diseases. ..
  50. DESIGN OF LIGANDS SELECTIVE FOR THE DAG SUPERFAMILY
    Alan Kozikowski; Fiscal Year: 2002
    ..To assess the effect of alterations in the ligand's hydrophobic side chain on its tumor promoting activity, studies of skin hyperplasia will be conducted. ..
  51. MECHANISMS OF NO-MEDIATED PROTEIN S-NITROSYLATION IN EAE
    OSCAR BIZZOZERO; Fiscal Year: 2007
    ..abstract_text> ..
  52. Pharmacogenetics of the Statin Response
    ERNST SCHAEFER; Fiscal Year: 2006
    ..These results can be used to formulate guidelines for identifying elderly subjects for statin treatment to prevent future CHD. ..
  53. International Conference on Biological Inorganic Chemistry
    Dimitri Coucouvanis; Fiscal Year: 2005
    ..A major use of the support sought in this application will assist mainly the junior participants of the meeting and particularly women and minorities among them. ..
  54. In Vivo EPR Imaging of Redox Status and Thiols in Tumor
    Periannan Kuppusamy; Fiscal Year: 2007
    ..The results will enable a better understanding of the development of drug resistance in ovarian cancer and offer efficient diagnosis for effective treatment of ovarian cancer patients. ..
  55. CONFERENCE/WORKSHOP ON EPR SPECTROSCOPY AND IMAGING
    Periannan Kuppusamy; Fiscal Year: 2005
    ..S. members of the International Advisory Committee for this meeting. Particular emphasis will be given to the minority and women scientists, encouraging their active participation. ..
  56. Polynuclear Clusters in Biology - Structure, Reactivity
    Dimitri Coucouvanis; Fiscal Year: 2005
    ..The function of the catecholate ligands in these compounds, as storage sites of oxidizing equivalents, will be determined. ..
  57. Identification and Significance of Protein Adducts
    Serrine Lau; Fiscal Year: 2008
    ..abstract_text> ..
  58. METABOLISM AND TOXICITY OF HYDROQUINONE-THIOETHERS
    Serrine Lau; Fiscal Year: 2003
    ..The overall goals of this aim are to characterize the Eker animal model in which the effects of environmental influences (chemical exposure) on a genetic predisposition to cancer are determined. ..
  59. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
    ..The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease. [unreadable] [unreadable] [unreadable]..
  60. Design and Synthesis of HIV-1 Protease Inhibitors
    AMOS SMITH; Fiscal Year: 2004
    ....
  61. PROSTANOID MEDIATED CYOPROTECTION
    Serrine Lau; Fiscal Year: 2001
    ..Experiments detailed in the Preliminary Data and Experimental sections of this grant application directly address this deficiency in our knowledge. ..
  62. H2S PRODUCTION AND VIRULENCE OF TREPONEMA DENTICOLA
    Lianrui Chu; Fiscal Year: 2007
    ..denticola to produce H2S from glutathione. The outcomes will elucidate the mechanisms of action that each member of the enzyme pathway plays in the virulence capacity of T. denticola. ..