Genomes and Genes
Summary: Compounds containing the -SH radical.
Publications296 found, 100 shown here
- Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione coupleF Q Schafer
Free Radical Research Institute and ESR Facility, The University of Iowa, Iowa City, IA 52242 1101, USA
Free Radic Biol Med 30:1191-212. 2001..These are the first steps toward a new quantitative biology, which hopefully will provide a rationale and understanding of the cellular mechanisms associated with cell growth and development, signaling, and reductive or oxidative stress...
- Protein S-nitrosylation: purview and parametersDouglas T Hess
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Nat Rev Mol Cell Biol 6:150-66. 2005..S-nitrosylation thereby conveys a large part of the ubiquitous influence of nitric oxide (NO) on cellular signal transduction, and provides a mechanism for redox-based physiological regulation...
- Thiol chemistry and specificity in redox signalingChristine C Winterbourn
Free Radical Research Group and the National Research Centre for Growth and Development, Department of Pathology, University of Otago, Christchurch, New Zealand
Free Radic Biol Med 45:549-61. 2008..We discuss areas where observations in cell systems can be rationalized with the reactivity of specific oxidants and where further work is needed to understand the mechanisms involved...
- Disulfide bonds as switches for protein functionPhilip J Hogg
Centre for Vascular Research, University of New South Wales, and Department of Haematology, Prince of Wales Hospital, NSW, Australia
Trends Biochem Sci 28:210-4. 2003..The function of some secreted soluble proteins and cell-surface receptors is controlled by cleavage of one or more of their disulfide bonds; this cleavage is mediated by catalysts or facilitators that are specific for their substrate...
- Generating disulfides enzymatically: reaction products and electron acceptors of the endoplasmic reticulum thiol oxidase Ero1pEinav Gross
Department of Structural Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
Proc Natl Acad Sci U S A 103:299-304. 2006..These findings provide insight into mechanisms for regenerating oxidized Ero1p and maintaining disulfide bond formation under anaerobic conditions in the endoplasmic reticulum...
- Mechanisms of reversible protein glutathionylation in redox signaling and oxidative stressMOLLY M GALLOGLY
Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, and the Louis Stokes Cleveland Veterans Affairs Medical Research Center, Cleveland, OH 44106 4965, United States
Curr Opin Pharmacol 7:381-91. 2007..Accordingly, this review focuses primarily on mechanisms of catalysis in mammalian systems...
- Cellular glutathione and thiols metabolismDale A Dickinson
Department of Environmental Health Sciences, Center for Free Radical Biology, School of Public Health, University of Alabama at Birmingham, 1530 3rd Avenue S, RPHB 317, Birmingham, AL 35294 0022, USA
Biochem Pharmacol 64:1019-26. 2002....
- Quantifying the global cellular thiol-disulfide statusRosa E Hansen
Department of Biology, University of Copenhagen, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
Proc Natl Acad Sci U S A 106:422-7. 2009..Accordingly, protein thiols are likely to be directly involved in the cellular defense against oxidative stress...
- Molecular mechanisms and potential clinical significance of S-glutathionylationIsabella Dalle-Donne
Department of Biology, University of Milan, Milan, Italy
Antioxid Redox Signal 10:445-73. 2008..Recently, specific PSSG have been identified in the inferior parietal lobule in Alzheimer's disease. However, much investigation is needed to clarify the actual involvement of protein S-glutathionylation in many human diseases...
- Ratiometric detection of mitochondrial thiols with a two-photon fluorescent probeChang Su Lim
Department of Chemistry, Korea University, 1 Anamdong, Seoul 136 701, Korea
J Am Chem Soc 133:11132-5. 2011....
- Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxideC C Winterbourn
Department of Pathology, Christchurch School of Medicine, New Zealand
Free Radic Biol Med 27:322-8. 1999..Due to the complexity of the chain reaction, no study so far has been able to obtain accurate values and we consider the best estimates to be in the 30 to 1000 M(-1) s(-1) range...
- S-glutathionylation in protein redox regulationIsabella Dalle-Donne
Department of Biology, University of Milan, I 20133 Milan, Italy
Free Radic Biol Med 43:883-98. 2007..In this review, we describe recent breakthroughs in our understanding of the potential role of protein S-glutathionylation in the redox regulation of signal transduction...
- Cysteinylation and homocysteinylation of plasma protein thiols during ageing of healthy human beingsR Rossi
Department of Evolutionary Biology, University of Siena, Siena, Italy
J Cell Mol Med 13:3131-40. 2009..The drop in the plasma level of protein sulphydryl groups suggests depletion and/or impairment of the antioxidant capacity of plasma, likely related to an alteration of the delicate balance between the different redox forms of thiols...
- Redox modifications of protein-thiols: emerging roles in cell signalingSaibal Biswas
Department of Biochemistry, Dr Ambedkar College, Nagpur, Maharashtra State, India
Biochem Pharmacol 71:551-64. 2006....
- Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transportEric J Niesor
Pharmaceuticals Division, F Hoffmann La Roche Ltd, Basel, Switzerland
J Lipid Res 51:3443-54. 2010..These data suggest that modulation of CETP activity by dalcetrapib does not inhibit CETP-induced pre-β-HDL formation, which may be required to increase reverse cholesterol transport...
- A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injuryTracy A Prime
MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, United Kingdom
Proc Natl Acad Sci U S A 106:10764-9. 2009..These results support the idea that selectively targeting NO(*) donors to mitochondria is an effective strategy to reversibly modulate respiration and to protect mitochondria against ischemia-reperfusion injury...
- Quick measurement of protein sulfhydryls with Ellman's reagent and with 4,4'-dithiodipyridineChristian K Riener
Institute of Biophysics, J Kepler University, Altenberger Str 69, A 4040 Linz, Austria
Anal Bioanal Chem 373:266-76. 2002..Electronic supplementary material to this paper can be obtained by using the Springer Link server located at http://dx.doi.org/10.1007/s00216-002-1347-2...
- Thiolated polymers--thiomers: development and in vitro evaluation of chitosan-thioglycolic acid conjugatesC E Kast
Institute of Pharmaceutical Technology and Biopharmaceutics, Center of Pharmacy, University of Vienna, Austria
Biomaterials 22:2345-52. 2001..According to these results. chitosan-TGA conjugates represent a promising tool for the development of mucoadhesive drug delivery systems...
- H2S signals through protein S-sulfhydrationAsif K Mustafa
Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Sci Signal 2:ra72. 2009..Sulfhydration augments GAPDH activity and enhances actin polymerization. Sulfhydration thus appears to be a physiologic posttranslational modification for proteins...
- The disulfide proteome and other reactive cysteine proteomes: analysis and functional significanceMarika Lindahl
Instituto de Bioquimica Vegetal y Fotosintesis, Consejo Superior de Investigaciones Científicas Universidad de Sevilla, Centro de Investigaciones Cientificas Isla de la Cartuja, Seville, Spain
Antioxid Redox Signal 14:2581-642. 2011..Thus, combined with biochemistry and genetics, disulfide proteomics has a significant potential to contribute to new discoveries on redox regulation and signaling...
- Hepatocyte-targeting single galactose-appended naphthalimide: a tool for intracellular thiol imaging in vivoMin Hee Lee
Department of Chemistry, Korea University, Seoul, 136 701, Korea
J Am Chem Soc 134:1316-22. 2012....
- Redox state of glutathione in human plasmaD P Jones
Department of Biochemistry, Atlanta, GA, USA
Free Radic Biol Med 28:625-35. 2000..These results suggest that E(h) values for GSSG/2GSH and CySS-mono-Gly/(Cys. CysGly) may provide useful means to quantitatively express the oxidant/antioxidant balance in clinical and epidemiologic studies...
- Albumin-bound low molecular weight thiols analysis in plasma and carotid plaques by CEAngelo Zinellu
Dept Biomedical Sciences, University of Sassari, Sassari, Italy
J Sep Sci 33:126-31. 2010..Due to the elevated sensitivity (LOD of 0.3 pM for all thiols), also low molecular weight thiols bound to albumin filtered in tissues could be quantified...
- Thiol metabolism play significant role during cadmium detoxification by Ceratophyllum demersum LSeema Mishra
Ecotoxicology and Bioremediation Group, National Botanical Research Institute, Rana Pratap Marg, Lucknow, Uttar Pradesh, India
Bioresour Technol 100:2155-61. 2009..In conclusion, under Cd stress, plants adapted to a new metabolic equilibrium of thiols through coordinated synthesis and consumption to combat Cd toxicity and to accumulate it...
- Thiol-based redox switches in eukaryotic proteinsNicolas Brandes
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
Antioxid Redox Signal 11:997-1014. 2009..Finally, we introduce the redox-sensitive protein tyrosine phosphatase PTP1B to illustrate that reversibility is one of the fundamental aspects of redox-regulation...
- Allosteric disulfide bondsBryan Schmidt
Centre for Vascular Research, University of New South Wales and Department of Haematology, Prince of Wales Hospital, Sydney, New South Wales 2052, Australia
Biochemistry 45:7429-33. 2006..We suggest that the -RHStaple configuration is a hallmark of allosteric disulfides. About 1 in 15 of all structurally determined disulfides is a potential allosteric bond...
- Is raising HDL a futile strategy for atheroprotection?Tisha Joy
Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada, N6A 5K8
Nat Rev Drug Discov 7:143-55. 2008..In this article, we review the complexity of HDL metabolism, discuss clinical-trial data for HDL-raising agents, including possible reasons for the failure of torcetrapib, and consider the potential for future HDL-based therapies...
- The high reactivity of peroxiredoxin 2 with H(2)O(2) is not reflected in its reaction with other oxidants and thiol reagentsAlexander V Peskin
Free Radical Research Group, Department of Pathology, University of Otago, P O Box 4345, Christchurch, New Zealand
J Biol Chem 282:11885-92. 2007..These results demonstrate that peroxiredoxin 2 has a tertiary structure that facilitates reaction of the active site thiol with hydrogen peroxide while restricting its reactivity with other thiol reagents...
- Palladacycles catalyse the oxidation of critical thiols of the mitochondrial membrane proteins and lead to mitochondrial permeabilization and cytochrome c release associated with apoptosisDebora P Santana
Centro Interdisciplinar de Investigação Bioquímica CIIB, Universidade de Mogi das Cruzes UMC, Av Dr Cândido Xavier de Almeida e Souza, 200 Mogi das Cruzes, Sao Paulo, Brazil
Biochem J 417:247-56. 2009..Besides the contribution to clarify the pro-apoptotic mechanism of PdC, this study shows that the catalysis of specific protein thiol cross-linkage is enough to induce mitochondrial permeabilization and cytochrome c release...
- Elaboration and characterization of thiolated chitosan-coated acrylic nanoparticlesIrene Bravo-Osuna
Laboratoire de Physicochimie, Pharmacotechnie et Biopharmacie, UMR CNRS 8612 Université Paris XI, Faculte de Pharmacie, 5, rue J B Clement, 92296 Chatenay Malabry, France
Int J Pharm 316:170-5. 2006..This new system, combining both the advantages of thiolated polymers and colloidal particles can be proposed as an original drug carrier system for mucosal delivery of biotechnology products...
- CGFS-type monothiol glutaredoxins from the cyanobacterium Synechocystis PCC6803 and other evolutionary distant model organisms possess a glutathione-ligated [2Fe-2S] clusterAntoine Picciocchi
CEA, iBiTec S, SBIGeM, LBI, Bat 142 CEA Saclay, F 91191 Gif sur Yvette Cedex, France
Biochemistry 46:15018-26. 2007..In light of these results, the involvement of these enzymes in the sensing of iron and/or the biogenesis and transfer of Fe-S cluster is discussed...
- Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin deliveryLichen Yin
State Key Laboratory of Genetic Engineering, Department of Pharmaceutical Sciences, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, China
Biomaterials 30:5691-700. 2009..Biocompatibility assessment revealed lack of toxicity of TMC-Cys NP. Therefore, self-assembled nanoparticles between TMC-Cys and protein drugs could be an effective and safe oral delivery system...
- Plastidial thioredoxin z interacts with two fructokinase-like proteins in a thiol-dependent manner: evidence for an essential role in chloroplast development in Arabidopsis and Nicotiana benthamianaBorjana Arsova
Max Planck Institute of Molecular Plant Physiology, Golm, Germany
Plant Cell 22:1498-515. 2010..Taken together, our data strongly suggest an important role for TRX z and both FLNs in the regulation of PEP-dependent transcription in chloroplasts...
- Quantifying changes in the thiol redox proteome upon oxidative stress in vivoLars I Leichert
Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 North University, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 105:8197-202. 2008..These experiments illustrate that OxICAT, which can be used in a variety of different cell types and organisms, is a powerful tool to identify, quantify, and monitor oxidative thiol modifications in vivo...
- Nitric oxide and thiol groupsB Gaston
University of Virginia Health System, Box 386, Charlottesville, VA 22908, USA
Biochim Biophys Acta 1411:323-33. 1999..These reactions are promising targets for the development of new medical therapies...
- Chloroplast monothiol glutaredoxins as scaffold proteins for the assembly and delivery of [2Fe-2S] clustersSibali Bandyopadhyay
Department of Chemistry, Centre for Metalloenzyme Studies, University of Georgia, Athens, GA, USA
EMBO J 27:1122-33. 2008..Alternatively, they may function in the storage and/or delivery of preformed Fe-S clusters or in the regulation of the chloroplastic Fe-S cluster assembly machinery...
- Nitric oxide activates TRP channels by cysteine S-nitrosylationTakashi Yoshida
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615 8510, Japan
Nat Chem Biol 2:596-607. 2006..These findings reveal the structural motif for the NO-sensitive activation gate in TRP channels and indicate that NO sensors are a new functional category of cellular receptors extending over different TRP families...
- Bacillithiol is an antioxidant thiol produced in BacilliGerald L Newton
Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, USA
Nat Chem Biol 5:625-7. 2009..Bacillithiol is the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid and most probably functions as an antioxidant. Bacillithiol, like the structurally similar mycothiol, may serve as a substitute for glutathione...
- Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted moleculeAmy Trott
Department of Microbiology and Molecular Genetics, University of Texas Medical School, Houston, TX 77030, USA
Mol Biol Cell 19:1104-12. 2008....
- Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloproteinAlbena T Dinkova-Kostova
The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, The Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Biochemistry 44:6889-99. 2005..Keap1 is a zinc-thiol protein endowed with a delicate switch controlled by both metal-binding and thiol reactivity...
- Role of ABC transporter MRPA, gamma-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovaniAngana Mukherjee
School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, India
J Antimicrob Chemother 59:204-11. 2007..The present work investigates the mechanism of resistance to SAG in parasites isolated from patients who are unresponsive to SAG...
- Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groupsA T Dinkova-Kostova
Department of Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 98:3404-9. 2001..This enhancement correlates with more rapid reactivity of the ortho-hydroxylated derivatives with model sulfhydryl compounds. Proton NMR spectroscopy provides no evidence for increased electrophilicity of the beta-vinyl carbons (the ..
- Cell-surface thiols affect cell entry of disulfide-conjugated peptidesSoline Aubry
UPMC Universite Paris 06, UMR 7613, Synthesis, Structure, and Function of Bioactive Molecules, Paris, France
FASEB J 23:2956-67. 2009....
- Mechanistic and kinetic details of catalysis of thiol-disulfide exchange by glutaredoxins and potential mechanisms of regulationMOLLY M GALLOGLY
Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106 4965, USA
Antioxid Redox Signal 11:1059-81. 2009..Part II presents potential mechanisms for in vivo regulation of Grx activity, providing avenues for future studies...
- The polarization of T(h)1/T(h)2 balance is dependent on the intracellular thiol redox status of macrophages due to the distinctive cytokine productionYukie Murata
Basic Research Laboratories, Ajinomoto Co Inc, 1 1 Suzuki cho, Kawasaki ku, Kawasaki 210 0861, Japan
Int Immunol 14:201-12. 2002..The findings implicate that the alteration in Mp functions because altered intracellular glutathione may play a relevant role in the pathological progression of inflammation...
- Ursodeoxycholic acid prevents selenite-induced oxidative stress and alleviates cataract formation: In vitro and in vivo studiesHui Ping Qi
Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, China
Mol Vis 18:151-60. 2012..To evaluate the antioxidative and anticataractogenic potential effect of ursodeoxycholic acid (UDCA) on selenite-induced cataract in vitro and in vivo...
- PEG hydrogels formed by thiol-ene photo-click chemistry and their effect on the formation and recovery of insulin-secreting cell spheroidsChien Chi Lin
Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University at Indianapolis, IN 46202, USA
Biomaterials 32:9685-95. 2011....
- Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trialZahi A Fayad
Translational and Molecular Imaging Institute and Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029, USA
Lancet 378:1547-59. 2011..dal-PLAQUE is the first multicentre study using novel non-invasive multimodality imaging to assess structural and inflammatory indices of atherosclerosis as primary endpoints...
- Substrate-, wavelength-, and time-dependent plasmon-assisted surface catalysis reaction of 4-nitrobenzenethiol dimerizing to p,p'-dimercaptoazobenzene on Au, Ag, and Cu filmsBin Dong
Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, P O Box 603 146, Beijing 100190, PR China
Langmuir 27:10677-82. 2011..Our experimental results revealed that optimal experimental conditions can be rationally chosen to control (accelerate or restrain) this reaction. The experimental results are also confirmed by theoretical calculations...
- Aryl methyl sulfides as substrates for rhodium-catalyzed alkyne carbothiolation: arene functionalization with activating group recyclingJoel F Hooper
Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK
J Am Chem Soc 134:2906-9. 2012..The utility of the alkenyl sulfide products is also demonstrated in simple carbo- and heterocycle-forming processes. We also provide mechanistic evidence for the course of this new process...
- Evaluation of low molecular mass thiols content in carotid atherosclerotic plaquesAngelo Zinellu
Dipartimento di Scienze Biomediche, Universita di Sassari, Italy Istituto Nazionale Biostrutture e Biosistemi, Osilo, Italy
Clin Biochem 42:796-801. 2009....
- Simple biosensor with high selectivity and sensitivity: thiol-specific biomolecular probing and intracellular imaging by AIE fluorogen on a TLC plate through a thiol-ene click mechanismYang Liu
Department of Chemistry, Institute of Molecular Functional Materials, The Hong Kong University of Science and Technology HKUST, Clear Water Bay, Kowloon, Hong Kong, China
Chemistry 16:8433-8. 2010..Clear fluorescence images were taken when living cells were stained by using TPE-MI as a visualization agent, affording a facile fluorescent maker for mapping the distribution of thiol species in cellular systems...
- Biosynthetic and iron metabolism is regulated by thiol proteome changes dependent on glutaredoxin-2 and mitochondrial peroxiredoxin-1 in Saccharomyces cerevisiaeBrian McDonagh
Department of Biochemistry and Molecular Biology and Córdoba Maimónides Institute for Biomedical Research IMIBIC, University of Cordoba, 14071 Cordoba, Spain
J Biol Chem 286:15565-76. 2011..Strikingly, requirement of Grx2p for these events places dithiolic Grx2 in the framework of iron metabolism...
- Characterization of natural antimony resistance in Leishmania donovani isolatesMukul K Mittal
Division of Biochemistry, Central Drug Research Institute, Lucknow, India
Am J Trop Med Hyg 76:681-8. 2007..These results suggest the possible role of thiols and MRPA in antimony resistance in field isolates...
- Thiol/disulfide redox states in signaling and sensingYoung Mi Go
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, GA 30322, USA
Crit Rev Biochem Mol Biol 48:173-81. 2013..Biological responses to cadmium, a widespread environmental agent, are used to illustrate the utility of these advances to the understanding of complex pleiotropic toxicities...
- Expression and activity of sulfate transporters and APS reductase in curly kale in response to sulfate deprivation and re-supplyAleksandra Koralewska
Laboratory of Plant Physiology, University of Groningen, 9750 AA Haren, The Netherlands
J Plant Physiol 166:168-79. 2009....
- Fluorescent and colorimetric probes for detection of thiolsXiaoqiang Chen
Department of Chemistry and Nano Science BK 21, Ewha Womans University, Seoul 120 750, Korea
Chem Soc Rev 39:2120-35. 2010....
- A two-photon fluorescent probe for thiols in live cells and tissuesJun Han Lee
Department of Chemistry, Korea University, 1 Anamdong, Seoul, 136 701, Korea
J Am Chem Soc 132:1216-7. 2010....
- Disulfide exchange in domain 2 of CD4 is required for entry of HIV-1Lisa J Matthias
Centre for Thrombosis and Vascular Research, School of Medical Sciences, University of New South Wales and Department of Haematology, Prince of Wales Hospital, Sydney, NSW 2052, Australia
Nat Immunol 3:727-32. 2002..These findings indicate that redox changes in CD4 D2 are important for HIV-1 entry and represent a new target for HIV-1 entry inhibitors...
- Endothelial function and aminothiol biomarkers of oxidative stress in healthy adultsSalman Ashfaq
Division of Cardiology, University of Kansas School of Medicine, Wichita, USA
Hypertension 52:80-5. 2008....
- Modulation of cell surface protein free thiols: a potential novel mechanism of action of the sesquiterpene lactone parthenolideJolanta Skalska
James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, United States of America
PLoS ONE 4:e8115. 2009..Given recent data to suggest that the redox status of extracellular protein thiol groups (i.e. exofacial thiols) effects cell behavior, we hypothesized that redox active anti-cancer agents would modulate exofacial protein thiols...
- Vicinal thiols are required for activation of the αIIbβ3 platelet integrinN Manickam
Division of Hematology, Department of Medicine, The University of Texas Health Science Center, San Antonio, TX, USA
J Thromb Haemost 9:1207-15. 2011..These thiols provide a mechanism to regulate protein function. We previously found that thiols in both αIIb and β3 of the αIIbβ3 fibrinogen receptor were required for platelet aggregation...
- Thioredoxin targets of the plant chloroplast lumen and their implications for plastid functionMichael Hall
Department of Chemistry, Umea3 University, Umea3, Sweden
Proteomics 10:987-1001. 2010..Our results indicate that redox-controlled reactions in the chloroplast lumen play essential roles in the function of photosystem II and the regulation of adaptation to light intensity...
- Mucoadhesive effect of thiolated PEG stearate and its modified NLC for ocular drug deliveryJie Shen
School of Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China
J Control Release 137:217-23. 2009..05), compared with the NLC without thiomer modification...
- Thiolated chitosans: development and in vitro evaluation of an oral tobramycin sulphate delivery systemJuliane Hombach
Institute of Pharmacy, Leopold Franzens University Innsbruck, Innrain 52, Josef Moller Haus, 6020 Innsbruck, Austria
Eur J Pharm Sci 33:1-8. 2008..The developed drug delivery system containing chitosan-NAC and glutathione is a promising tool for oral tobramycin sulphate administration showing improved gastrointestinal uptake and a sustained release...
- Vascular effects and safety of dalcetrapib in patients with or at risk of coronary heart disease: the dal-VESSEL randomized clinical trialThomas F Luscher
Department of Cardiology, Cardiovascular Centre, University of Zurich, 8091 Zurich, Switzerland
Eur Heart J 33:857-65. 2012..gov number NCT00655538)...
- Reaction based fluorescent probes for hydrogen sulfideChunrong Liu
Department of Chemistry, Washington State University, Pullman, Washington 99164, USA
Org Lett 14:2184-7. 2012..Other biological thiols such as cysteine and glutathione did not pursue the reaction and therefore did not turn on the fluorescence/consume the substrates. The probes showed good selectivity and sensitivity for hydrogen sulfide...
- A rhodamine-based fluorescent probe containing a Se-N bond for detecting thiols and its application in living cellsBo Tang
Chemical Engineering and Materials Science, Engineering Research Center of Pesticide and Medicine Intermediate Clean Production, College of Chemistry, Ministry of Education, Shandong Normal University, Jinan, People s Republic of China
J Am Chem Soc 129:11666-7. 2007
- Preactivated thiomers as mucoadhesive polymers for drug deliveryJaved Iqbal
Department of Pharmaceutical Technology, Leopold Franzens University Innsbruck, Innsbruck, Austria
Biomaterials 33:1528-35. 2012..Thus, on the basis of achieved results the pre-activated thiomers seem to represent a promising generation of mucoadhesive polymers which are safe to use for prolonged residence time of drug delivery systems to target various mucosa...
- SIN-1 cytotoxicity to PC12 cells is mediated by thiol-sensitive short-lived substances generated through SIN-1 decomposition in culture mediumKanako Konishi
Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, Japan
Nitric Oxide 20:270-8. 2009..These results suggest that SIN-1 cytotoxicity in PC12 cells is mediated via the generation of cytotoxic substances in the medium during its decomposition...
- Tumor-specific targeting of sodium borocaptate (BSH) to malignant glioma by transferrin-PEG liposomes: a modality for boron neutron capture therapyAtsushi Doi
Department of Neurosurgery, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka 569 8686, Japan
J Neurooncol 87:287-94. 2008..To improve a drug delivery in BNCT, we devised transferrin-conjugated polyethylene-glycol liposome encapsulating sodium borocaptate (TF-PEG-BSH)...
- Chitosan-graft-6-mercaptonicotinic acid: synthesis, characterization, and biocompatibilityGioconda Millotti
Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold Franzens University, Innrain 52c, Josef Moller Haus, Innsbruck, Austria
Biomacromolecules 10:3023-7. 2009..The reactivity of thiol groups was in the same range at pH 3 and pH 6.8. According to these results, chitosan-6 mercaptonicotinic acid seems to have some promising features to be used particularly for mucoadhesive formulations...
- Direct observation of disulfide isomerization in a single proteinJorge Alegre-Cebollada
Department of Biological Sciences, Columbia University, Northwest Corner Building, 550 West 120 Street, New York, New York 10027, USA
Nat Chem 3:882-7. 2011..This allowed us to measure, for the first time, the kinetics of disulfide-bond isomerization in a protein...
- Redox proteomics: identification of oxidatively modified proteinsPietro Ghezzi
Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy
Proteomics 3:1145-53. 2003....
- Different effects of compounds decreasing cholesteryl ester transfer protein activity on lipoprotein metabolismEric J Niesor
Pharmaceuticals Division, F Hoffmann La Roche Ltd, Basel, Switzerland
Curr Opin Lipidol 22:288-95. 2011....
- Gastroprotective mechanisms of Citrus lemon (Rutaceae) essential oil and its majority compounds limonene and β-pinene: involvement of heat-shock protein-70, vasoactive intestinal peptide, glutathione, sulfhydryl compounds, nitric oxide and prostaglandin EAriane Leite Rozza
Morphology Department, Biosciences Institute, Univ Estadual Paulista, Botucatu, SP, Brazil
Chem Biol Interact 189:82-9. 2011..CL gastroprotective mechanism is involved with PGE₂. PIN did not present gastroprotective activity...
- Anacetrapib and dalcetrapib: two novel cholesteryl ester transfer protein inhibitorsMarta A Miyares
Pharmacy Department, Jackson Memorial Hospital, Miami, FL, USA
Ann Pharmacother 45:84-94. 2011....
- Drevogenin D prevents selenite-induced oxidative stress and calpain activation in cultured rat lensP G Biju
Department of Biochemistry, University of Kerala, Kerala, India
Mol Vis 13:1121-9. 2007..The purpose of the study was to evaluate the role of Drevogenin D, a triterpenoid aglycone, isolated from Dregea volubilis in preventing selenite-induced, calcium-activated, calpain-mediated proteolysis in cultured rat lenses...
- Cystic fibrosis transmembrane conductance regulator: using differential reactivity toward channel-permeant and channel-impermeant thiol-reactive probes to test a molecular model for the poreChristopher Alexander
Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239, USA
Biochemistry 48:10078-88. 2009..The results provide an initial validation of two, new molecular models for CFTR and suggest that molecular dynamics simulation will be a useful tool for unraveling the structural basis of anion conduction by CFTR...
- Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damageRaquel Requejo
MRC Mitochondrial Biology Unit, Wellcome Trust MRC Building, Cambridge, UK
FEBS J 277:1465-80. 2010..Therefore, exposed protein thiols are the dominant free thiol within the cell and may play a critical role in intracellular antioxidant defences against oxidative damage...
- OxyR: a molecular code for redox-related signalingSung Oog Kim
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Cell 109:383-96. 2002....
- Tuning of shell and core characteristics of chitosan-decorated acrylic nanoparticlesI Bravo-Osuna
CNRS, UMR CNRS 8612, Faculte de Pharmacie, 5 rue J B Clement, 92296 Chatenay Malabry, France
Eur J Pharm Sci 30:143-54. 2007..Positive surface charge values were obtained in all cases. In addition, evidences of the presence of thiol groups were obtained (0.03-0.16 x 10(-3)micromol/cm(2) of nanoparticle)...
- A bystander effect observed in boron neutron capture therapy: a study of the induction of mutations in the HPRT locusYuko Kinashi
Research Reactor Institute, Kyoto University, Osaka, Japan
Int J Radiat Oncol Biol Phys 68:508-14. 2007..The BSH-containing cells were irradiated with alpha-particles produced by the 10B(n,alpha)7Li reaction, whereas cells without boron were affected only by the 1H(n,gamma)2H and 14N(n,rho)14C reactions...
- Monofunctional gold nanoparticles prepared via a noncovalent-interaction-based solid-phase modification approachXiong Liu
Nanoscience Technology Center and Department of Chemistry, University of Central Florida, 12424 Research Parkway Suit 400, Orlando, FL 32826, USA
Small 2:1126-9. 2006
- Thiols in cellular redox signalling and controlL K Moran
Unit of Critical Care, The Royal Brompton Hospital, Imperial College School of Medicine. Sydney Street, London, SW3 6NP, UK
Curr Med Chem 8:763-72. 2001..Particular attention has been paid to the importance of thiols and thiol-containing molecules in these processes...
- S-glutathionylation: from redox regulation of protein functions to human diseasesDaniela Giustarini
Department of Neuroscience, University of Siena, Siena, Italy
J Cell Mol Med 8:201-12. 2004..S-glutathionylated proteins are now actively investigated with reference to problems of biological interest and as possible biomarkers of human diseases associated with oxidative/nitrosative stress...
- Kinetics and mechanism of the reaction of cysteine and hydrogen peroxide in aqueous solutionDayong Luo
Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40506, USA
J Pharm Sci 94:304-16. 2005..A thorough understanding of the mechanism in aqueous solution will provide valuable background information for current studies aimed at elucidating the influence of such factors on thiol oxidation in solid-state formulations...
- Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosisMd Firoz Mian
Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang 790 784, South Korea
Chem Biol Interact 171:57-66. 2008..From the present results, it is more likely that not cell detachment but the proteolytic cleavage (or inhibition) of FAK is a key modulator as well as a promising indicator of apoptosis in epithelial cells under oxidative stress...
- Glutathione peroxidase, thioredoxin, and membrane protein changes in erythrocytes predict ribavirin-induced anemiaIgnazio Grattagliano
Section of Internal Medicine, Department of Internal Medicine and Public Medicine, University of Bari, Bari, Italy
Clin Pharmacol Ther 78:422-32. 2005..Low erythrocyte membrane protein sulfhydril concentrations are a risk factor for ribavirin-induced anemia. We further studied the role of oxidative stress and erythrocyte membrane alterations in ribavirin-induced anemia...
- Quantification of thiol-containing amino acids linked by disulfides to LDLAngelo Zinellu
University of Sassari, Viale San Pietro 43 B, 07100 Sassari, Italy
Clin Chem 51:658-60. 2005
- Intracellular targeting of sodium mercaptoundecahydrododecaborate (BSH) to solid tumors by transferrin-PEG liposomes, for boron neutron-capture therapy (BNCT)Kazuo Maruyama
Department of Pharmaceutics, Teikyo University, Sagamiko, Kanagawa 199 0195, Japan
J Control Release 98:195-207. 2004..These results suggest that BSH-encapsulating TF-PEG liposomes may be useful as a new intracellular targeting carrier in BNCT therapy for cancer...
- Reactive oxygen metabolites and prooxidant status in children with Down's syndromeM Carratelli
Diacron S.r.l, Diagnostic Division, Grosseto, Italy
Int J Clin Pharmacol Res 21:79-84. 2001..The new test available for measuring reactive oxygen species in serum proved to be reliable and useful as an early marker of tissue damage...
- Oxidoreduction of protein thiols in redox regulationP Ghezzi
Mario Negri Institute, Via Eritrea 62, 20157 Milan, Italy
Biochem Soc Trans 33:1378-81. 2005..This review discusses the evolution of the concept of redox regulation from that of oxidative stress and the redox state of protein cysteines in different cellular compartments...
- Proteomics of Arabidopsis redox proteins in response to methyl jasmonateSophie Alvarez
Department of Botany and Zoology, Genetics Institute, The Plant Molecular and Cellular Biology Program, University of Florida, Gainesville, FL 32611, USA
J Proteomics 73:30-40. 2009..Identification of redox proteins and their cysteine residues involved in the redox regulation allows for a deeper understanding of the jasmonate signaling networks...
- Bioelectronic detector with monoamine oxidase for halitosis monitoringT Minamide
Graduate School of Engineering, Tokai University, Hiratsuka, Japan
Analyst 130:1490-4. 2005..The output of bio-detector showed behaviour of halitosis level changes in a day such as increasing with passage of time and decreasing after eating...
- Plasma thiols redox status by laser-induced fluorescence capillary electrophoresisCiriaco Carru
Chair of Clinical Biochemistry, University of Sassari, Viale San Pietro 43 B, I 07100 Sassari, Italy
Electrophoresis 25:882-9. 2004..Linearity, reproducibility, analytical recovery, and sensitivity were evaluated. The assay was used to measure the thiols redox status in 15 plasma samples from healthy volunteers...
- Analysis of plasma thiols by high-performance liquid chromatography with ultraviolet detectionE Bald
Department of Environmental Chemistry, University of Lodz, 163 Pomorska Street, 90 236 Lodz, Poland
J Chromatogr A 1032:109-15. 2004..The method is linear within the physiological and pathological ranges of thiols and is applied for plasma samples donated by apparently healthy volunteers...
- Age-related influence on thiol, disulfide, and protein-mixed disulfide levels in human plasmaDaniela Giustarini
Department of Neuroscience, Pharmacology Unit, University of Siena, Via A Moro 4, I 53100, Siena, Italy
J Gerontol A Biol Sci Med Sci 61:1030-8. 2006..The occurrence of two distinct regulatory systems for plasmatic pools of glutathione/cysteinylglycine on the one hand and cysteine/homocysteine on the other hand is hypothesized...
- Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: thiomer/GSH systemsA Bernkop-Schnürch
Institute of Pharmaceutical Technology and Biopharmaceutics, Center of Pharmacy, University of Vienna, Althanstr 14, A 1090 Vienna, Austria
J Control Release 93:95-103. 2003....
- Identification of thioredoxin h-reducible disulphides in proteomes by differential labelling of cysteines: insight into recognition and regulation of proteins in barley seeds by thioredoxin hKenji Maeda
Department of Chemistry, Carlsberg Laboratory, Copenhagen, Denmark
Proteomics 5:1634-44. 2005..For the first time, specificity of thioredoxin h for particular disulphide bonds is demonstrated, providing a basis to study structural aspects of the recognition mechanism and regulation of target proteins...
- A sensitive method for the quantitative measurement of protein thiol modification in response to oxidative stressAimee Landar
Department of Pathology, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Free Radic Biol Med 40:459-68. 2006..Thus, we have developed a versatile, cost-effective standard that can be used in proteomic methods to quantitate biotin tags in response to oxidative stress...
- BIOLOGY OF MYOCARDIAL ISCHEMIAMark Entman; Fiscal Year: 1990..of oxidative stress by measuring lipid hydroxy-acids and hydroperoxides as well as the redox of various sulfhydryl compounds (glutathione, protein mixed disulfides) in cardiac lymph and myocardial biopsy samples...
- MYLEOPEROXIDASE AND LEUKOCYTE GRANULE COMPONENTSEDWIN THOMAS; Fiscal Year: 1992..in H202 production and an oxidant for extracellular reductants such as ascorbate (vitamin C) and sulfhydryl compounds. Oxidation of these reductants by 02-increases H202 production and consumes the reductants so that they can'..
- ANTAGONISM OF SELENIUM FUNCTION BY MERCAPTANSGERALD COMBS; Fiscal Year: 1990..The results can be expected to yield information relevant to both the mode of action of mercaptans and the metabolic function of Se...
- MECHANISM-BASED THERAPEUTICS EXPLOITING TUMOR BIOLOGYFrancis Sirotnak; Fiscal Year: 1999..The mechanism of activation of lysosomal folyl polyglutamate hydrolase by endogenous reduced sulfhydryl compounds will also be examined...
- Metabolic effects of chemical interactions in toxicityDean Jones; Fiscal Year: 2005....
- Metabolic analysis in human sulfur amino acid deficiencyDean Jones; Fiscal Year: 2005..g., 300 samples/day with a flow cell), results will show whether this approach could be useful for nutritional assessment of complex metabolic effects of SAA intake. ..
- PP2A-Like Constitutive ERK/MAPK Phosphatase in BrainTimothy Foley; Fiscal Year: 2003....
- NOVEL NONINDUCIBLE THYMIDYLATE SYNTHASE INHIBITORSAleem Gangjee; Fiscal Year: 2004....
- Third Generation Antiopportunistic AgentsAleem Gangjee; Fiscal Year: 2003..Screening against tuberculosis (NIAID) and tumor cells in culture (NCI) is also proposed. ..
- Novel, P. jirovecii Specific Antipneumocystis AgentsAleem Gangjee; Fiscal Year: 2009..These agents could be used alone or in combination to treat PCP thus providing novel agents against a new target. ..
- Pediatric Severe Asthma: Role of Oxidant Stress and Alveolar Macrophage FunctionAnne Fitzpatrick; Fiscal Year: 2009..This proposal will lay the foundation for further studies, and the mechanisms identified may ultimately be targeted in future interventional trials. ..
- Dietary Cysteine:Conceptal Response to Oxidative StressCraig Harris; Fiscal Year: 2002....
- Novel Single, Dual and Multitargeted Inhibitors of RTKsAleem Gangjee; Fiscal Year: 2007..abstract_text> ..
- STRUCTURE BASED ANALOGS AS ANTIOPPORTUNISTIC AGENTSAleem Gangjee; Fiscal Year: 2001..The analogues synthesized will also be submitted for screening against tuberculosis (NIAID) parasitic diseases (WHO) and tumor cells in culture (NCI). ..
- Alpha Folate Receptor Mediated GARFTase Inhibitors as Selective Antitumor AgentsAleem Gangjee; Fiscal Year: 2010....
- Single Agents with Designed Combination Chemotherapy PotentialAleem Gangjee; Fiscal Year: 2010..abstract_text> ..
- Antitumor Antimitotics That Reverse Tumor ResistanceAleem Gangjee; Fiscal Year: 2010..The study will also further define the mechanism of action of the novel series and could afford agents for clinical use. ..
- Nanoparticles for Molecular MRI of AtherosclerosisZahi Fayad; Fiscal Year: 2008..These studies will provide the basis for future advances in experimental studies of atherosclerogenesis and new clinical applications of non-invasive, in vivo MR imaging of atherosclerotic lesions. [unreadable] [unreadable] [unreadable]..
- Isothiocyanates in the Chemoprevention of Bladder CancerYuesheng Zhang; Fiscal Year: 2007..Aim 5 will determine the efficacy of an orally administered ITC in inhibiting N-butyl-N- (4-hydroxybutyl)-nitrosamine-induced bladder tumorigenesis in F344 rats. ..
- Human Lung Chromium Toxicity: Role of cytochrome b5Charles Myers; Fiscal Year: 2007..They will provide a deeper understanding of the mechanisms underlying Cr(VI) toxicity in human lung, and will lead to new insights on the role of b5 in toxicant activation [unreadable] [unreadable]..
- Vision Research Infrastructure Development Grant (R24)FRANK GIBLIN; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- SYNTHESIS OF SPONGISTATIN ANTITUMOR AGENTSAMOS SMITH; Fiscal Year: 2007..abstract_text> ..
- Portable Analyzer for On-site Monitoring of Worker Exposure to Toxic MetalsCharles Timchalk; Fiscal Year: 2007..Ultimately, the sensor for metal ions will be combined with the sensor for creatinine so that the exposure monitoring can be performed with "spot" urine instead of 24-hr urine. [unreadable] [unreadable] [unreadable]..
- CVN-12p1 Chimeras and Combinations for AIDS MicrobiocidesIrwin Chaiken; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Novel Methods for in Vivo Imaging of Tissue OxygenationPeriannan Kuppusamy; Fiscal Year: 2008..The technology should offer exciting new opportunities in the field of biomedical imaging of free radicals and oxygen. ..
- Biomimetic Studies of NO-binding Respiratory Chain HemesJAMES COLLMAN; Fiscal Year: 2008..An emphasis will be placed on kinetic and mechanistic studies to elucidate the putitive reaction pathways of CcO and NOR. ..
- Multifunctional reagents for proteomic analysisCHRISTIAN SCHONEICH; Fiscal Year: 2008..unreadable] [unreadable]..
- Obesity, Inflammation and Thrombosis: LOOK AHEADChristie M Ballantyne; Fiscal Year: 2010....
- Polynuclear Clusters in Nitrogenase-Structure ReactivityDimitri Coucouvanis; Fiscal Year: 2007..abstract_text> ..
- PKC Modulators for the Treatment of Alzheimer's diseaseAlan Kozikowski; Fiscal Year: 2008..For the best compounds from Aim 2, perform studies in triple transgenic mice to ascertain effects on Abeta and sAPPalpha levels and plaque formation in vivo. ..
- Design and Development of Pharmacotherapies for Treating Stimulant AbuseFrank Ivy Carroll; Fiscal Year: 2010..3) To continue on a limited basis our development of selected 3-phenyltropane analogs as second-generation pharmacotherapies to treat cocaine addiction. ..
- COCAINE: A STUDY OF THE BIOCHEMICAL MECHANISM OF ACTIONFrank Carroll; Fiscal Year: 2007..abstract_text> ..
- SYNTHESIS OF ANTICANCER AGENTSK C Nicolaou; Fiscal Year: 2010..abstract_text> ..
- MOLECULAR BASIS OF HIGH DENSITY LIPOPROTEIN DEFICIENCYERNST SCHAEFER; Fiscal Year: 2009..The results of this work will provide important insight into the contribution of allelic variation in the pathways of HDL metabolism, inflammation, and insulin resistance to the complex phenotype of low HDL-C. ..
- Cd2+, Metallothionein and Transcriptional Control of Na+ Glucose Co-Transporter 1DAVID PETERING; Fiscal Year: 2009..abstract_text> ..
- NOVEL PHARMACOTHERAPY FOR TREATMENT OF COCAINE ADDICTIONFrank Carroll; Fiscal Year: 2008..abstract_text> ..
- NEW SYNTHETIC METHODS FOR ANTICANCER RESEARCHLANNY LIEBESKIND; Fiscal Year: 2001..Using cyclobutenedione methodology as a seminal component of each system, metallaquinones and porphyrin quinones are being developed as novel anticancer agents. ..
- DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISKERNST SCHAEFER; Fiscal Year: 2003..abstract_text> ..
- EPR IMAGING OF TUMOR HETEROGENEITY AND OXYGENATIONPeriannan Kuppusamy; Fiscal Year: 2003..Information obtained from these studies should enable the development and optimization of therapeutic modalities for cancer treatment. ..
- POSTTRANSLATIONAL MODIFICATION/STRUCTURE-FUNCTION OF BONErdjan Salih; Fiscal Year: 2003....
- MAC 1/LFA 1/P150 95 AND PMN LEUKOCYTE FUNCTIONChristie Ballantyne; Fiscal Year: 2002..3. Characterize the contribution of each CD11 integrin on the host response to common bacterial and fungal pathogens in vitro and in vivo. ..
- MERCURY NEPHROTOXICITY AFTER A REDUCTION OF RENAL MASSRUDOLFS ZALUPS; Fiscal Year: 2002..abstract_text> ..
- HPLC DETECTION OF RADICAL INTERMEDIATESDetcho Stoyanovsky; Fiscal Year: 2002..The method is expected to display several orders of magnitude higher sensitivity than then traditional ESR spin trapping technique and may be a new approach in assays of oxidative stress. ..
- MODELING OF MIXED LIGAND THERAPY FOR IRON OVERLOADRobert Hider; Fiscal Year: 2002..We aim to define the principles and potential candidates for optimal mixed ligand therapy for iron overload. ..
- OUTER MEMBRANE CYTOCHROMES--TOPOLOGY AND FUNCTIONCharles Myers; Fiscal Year: 2002..They will also contribute to environmental health by expanding our knowledge on the mechanisms by which manganese, iron, and various heavy metals are mobilized into water supplies. ..
- SYNTHESIS OF CHLOROPEPTINS, GP120 CD4 BINDING INHIBITORSAMOS SMITH; Fiscal Year: 2001..abstract_text> ..
- BIOLOGICAL STUDIES OF PIPERIDINE ANALOGS OF COCAINEAlan Kozikowski; Fiscal Year: 2001..4. For compounds meeting set criteria, to further evaluate their behavioral pharmacological profile in animals using intravenous drug self-administration and drug discrimination procedures. ..
- CHANNEL-MEDIATED RBC DEHYDRATION IN SICKLE CELL DISEASEAlicia Rivera; Fiscal Year: 2003..It is additionally significant, because it will provide the means for the applicant to establish an independent research career and to become competitive for a tenure-track assistant professional position. ..
- INTERLEUKIN 5 RECEPTOR RECOGNITION, MIMETICS, ANTAGONISMIrwin Chaiken; Fiscal Year: 2004..And it will yield antagonist strategies which could lead to molecular tools for therapeutic intervention in asthma and other allergic diseases. ..
- DESIGN OF LIGANDS SELECTIVE FOR THE DAG SUPERFAMILYAlan Kozikowski; Fiscal Year: 2002..To assess the effect of alterations in the ligand's hydrophobic side chain on its tumor promoting activity, studies of skin hyperplasia will be conducted. ..
- MECHANISMS OF NO-MEDIATED PROTEIN S-NITROSYLATION IN EAEOSCAR BIZZOZERO; Fiscal Year: 2007..abstract_text> ..
- Pharmacogenetics of the Statin ResponseERNST SCHAEFER; Fiscal Year: 2006..These results can be used to formulate guidelines for identifying elderly subjects for statin treatment to prevent future CHD. ..
- International Conference on Biological Inorganic ChemistryDimitri Coucouvanis; Fiscal Year: 2005..A major use of the support sought in this application will assist mainly the junior participants of the meeting and particularly women and minorities among them. ..
- In Vivo EPR Imaging of Redox Status and Thiols in TumorPeriannan Kuppusamy; Fiscal Year: 2007..The results will enable a better understanding of the development of drug resistance in ovarian cancer and offer efficient diagnosis for effective treatment of ovarian cancer patients. ..
- CONFERENCE/WORKSHOP ON EPR SPECTROSCOPY AND IMAGINGPeriannan Kuppusamy; Fiscal Year: 2005..S. members of the International Advisory Committee for this meeting. Particular emphasis will be given to the minority and women scientists, encouraging their active participation. ..
- Polynuclear Clusters in Biology - Structure, ReactivityDimitri Coucouvanis; Fiscal Year: 2005..The function of the catecholate ligands in these compounds, as storage sites of oxidizing equivalents, will be determined. ..
- Identification and Significance of Protein AdductsSerrine Lau; Fiscal Year: 2008..abstract_text> ..
- METABOLISM AND TOXICITY OF HYDROQUINONE-THIOETHERSSerrine Lau; Fiscal Year: 2003..The overall goals of this aim are to characterize the Eker animal model in which the effects of environmental influences (chemical exposure) on a genetic predisposition to cancer are determined. ..
- NMR systems : 2 Bruker Avance 500 ConsolesAMOS SMITH; Fiscal Year: 2006..The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease. [unreadable] [unreadable] [unreadable]..
- Design and Synthesis of HIV-1 Protease InhibitorsAMOS SMITH; Fiscal Year: 2004....
- PROSTANOID MEDIATED CYOPROTECTIONSerrine Lau; Fiscal Year: 2001..Experiments detailed in the Preliminary Data and Experimental sections of this grant application directly address this deficiency in our knowledge. ..
- H2S PRODUCTION AND VIRULENCE OF TREPONEMA DENTICOLALianrui Chu; Fiscal Year: 2007..denticola to produce H2S from glutathione. The outcomes will elucidate the mechanisms of action that each member of the enzyme pathway plays in the virulence capacity of T. denticola. ..