Genomes and Genes
Summary: Sodium or sodium compounds used in foods or as a food. The most frequently used compounds are sodium chloride or sodium glutamate.
Publications229 found, 100 shown here
- Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research GroupF M Sacks
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
N Engl J Med 344:3-10. 2001..We studied the effect of different levels of dietary sodium, in conjunction with the Dietary Approaches to Stop Hypertension (DASH) diet, which is rich in vegetables, ..
- How far should salt intake be reduced?Feng J He
Blood Pressure Unit, St George s Hospital Medical School, Cranmer Terrace, London, England
Hypertension 42:1093-9. 2003..A further reduction to 3 g/d will have a much greater effect and should now become the long-term target for population salt intake worldwide...
- Effects of dietary sodium reduction on blood pressure in subjects with resistant hypertension: results from a randomized trialEduardo Pimenta
Hypertension Unit, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Brisbane, QLD, Australia
Hypertension 54:475-81. 2009Observational studies indicate a significant relation between dietary sodium and level of blood pressure. However, the role of salt sensitivity in the development of resistant hypertension is unknown...
- Urinary sodium excretion and cardiovascular mortality in Finland: a prospective studyJ Tuomilehto
Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
Lancet 357:848-51. 2001..We aimed to find out whether salt intake, measured by 24 h urinary sodium excretion, is an independent risk factor for cardiovascular disease frequency and mortality, and all-cause mortality...
- Effect of renin-angiotensin-aldosterone system inhibition, dietary sodium restriction, and/or diuretics on urinary kidney injury molecule 1 excretion in nondiabetic proteinuric kidney disease: a post hoc analysis of a randomized controlled trialFemke Waanders
Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Am J Kidney Dis 53:16-25. 2009..We hypothesized that a decrease in proteinuria by using therapeutic interventions is associated with decreased urinary KIM-1 levels...
- Long-term effects of weight loss and dietary sodium reduction on incidence of hypertensionJ He
Department of Epidemiology, the Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112 2699, USA
Hypertension 35:544-9. 2000To examine the long-term effects of weight loss and dietary sodium reduction on the incidence of hypertension, we studied 181 men and women who participated in the Trials of Hypertension Prevention, phase 1, in Baltimore, Md...
- Effect of dietary sodium intake on blood lipids: results from the DASH-sodium trialDavid W Harsha
Pennington Biomedical Research Center, Baton Rouge, LA, USA
Hypertension 43:393-8. 2004..There were no significant interactions between the effects of sodium and the DASH diet on serum lipids. In conclusion, changes in dietary sodium intake over the range of 50 to 150 mmol/d did not affect blood lipid concentrations.
- Estimate of the benefits of a population-based reduction in dietary sodium additives on hypertension and its related health care costs in CanadaMichel R Joffres
Simon Fraser University, Burnaby, British Columbia, Canada
Can J Cardiol 23:437-43. 2007..Reductions in dietary sodium additives significantly lower systolic and diastolic blood pressure, and population reductions in dietary ..
- Relations between dietary sodium and potassium intakes and mortality from cardiovascular disease: the Japan Collaborative Cohort Study for Evaluation of Cancer RisksMitsumasa Umesawa
Department of Public Health Medicine, Graduate School of Comprehensive Human Sciences, and the Institute of Community Medicine, University of Tsukuba, Tsukuba, Japan
Am J Clin Nutr 88:195-202. 2008..Limited evidence is available about the relations between sodium and potassium intakes and cardiovascular disease in the general population...
- Effect of aerobic exercise training on blood pressure sensitivity to dietary sodium in older hypertensivesD R Dengel
School of Kinesiology, University of Minnesota, Minneapolis, 55455, USA
J Hum Hypertens 20:372-8. 2006..exercise training has been shown to lower blood pressure (BP) in older adults, its effect on BP sensitivity to dietary sodium (Na(+)) is unknown...
- Effects of aging and alterations in dietary sodium intake on total nitric oxide productionR J Schmidt
Departments of Medicine and Physiology, West Virginia University, Morgantown, WV 26506, USA
Am J Kidney Dis 37:900-8. 2001..Limitations of blood and urine measurements of NO(2) + NO(3) and cGMP as indices of NO activity are discussed...
- A review of methods to measure dietary sodium intakeBrooke Bentley
Student College of Nursing, University of Kentucky, Lexington, KY, USA
J Cardiovasc Nurs 21:63-7. 2006With the rising prevalence of heart failure, it is imperative to investigate reasons for dietary sodium nonadherence and to develop evidence-based interventions to promote adherence...
- Central angiotensin modulation of baroreflex control of renal sympathetic nerve activity in the rat: influence of dietary sodiumG F DiBona
Department of Internal Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
Acta Physiol Scand 177:285-9. 2003..an intact blood-brain barrier to assess the role of endogenous angII of brain origin and (c) alterations in dietary sodium intake, a known physiological regulator of activity of the renin-angiotensin system (RAS), to assess the ..
- ACE inhibition has adverse renal effects during dietary sodium restriction in proteinuric and healthy ratsI Hamming
Department of Pathology and Laboratory Medicine, University Medical Center Groningen and University of Groningen, The Netherlands
J Pathol 209:129-39. 2006..Further studies should elucidate the mechanisms underlying these observations and their impact on long-term renoprotection...
- Dietary sodium deprivation evokes activation of brain regional neurons and down-regulation of angiotensin II type 1 receptor and angiotensin-convertion enzyme mRNA expressionB Lu
Department of Physiology and Pathophysiology, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, School of Medicine, Xi an Jiaotong University, 76 W Yanta Road, Xi an, 710061, PR China
Neuroscience 164:1303-11. 2009..system (RAAS) is implicated in the induction of sodium appetite in rats and that different dietary sodium intakes influence the mRNA expression of central and peripheral RAAS components...
- Changes in urinary stone risk factors in hypocitraturic calcium oxalate stone formers treated with dietary sodium supplementationMarshall L Stoller
Department of Urology, School of Medicine, University of California San Francisco, San Francisco, California, USA
J Urol 181:1140-4. 2009We investigated the effects of supplemental dietary sodium on risk factors for urinary stone disease in stone forming patients with hypocitraturia.
- Sodium in the Finnish diet: II trends in dietary sodium intake and comparison between intake and 24-h excretion of sodiumH Reinivuo
Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
Eur J Clin Nutr 60:1160-7. 2006To estimate cross-sectional and long-term dietary sodium intakes and sources in Finland, and to evaluate the validity of 48-h recall to assess sodium intake.
- Heritability of blood pressure responses to dietary sodium and potassium intake in a Chinese populationDongfeng Gu
Cardiovascular Institute and Fu Wai Hospital, Beijing, China
Hypertension 50:116-22. 2007..We examined the heritability of blood pressure responses to dietary sodium and potassium intake in a family feeding study among 1906 study participants living in rural North China...
- Influence of dietary sodium on the blood pressure and renal sympathetic nerve activity responses to intracerebroventricular angiotensin II and angiotensin III in anaesthetized ratsBelinda L Houghton
Department of Physiology, Windle Building, University College Cork, College Road, Cork, Republic of Ireland
Exp Physiol 95:282-95. 2010..c.v. AngII and AngIII; (2) highlight an important role for peripheral V(1) receptors during these responses; and (3) differentiate the effects of AngII and AngIII on blood pressure and RSNA...
- Sodium intake and mortality follow-up in the Third National Health and Nutrition Examination Survey (NHANES III)Hillel W Cohen
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Gen Intern Med 23:1297-302. 2008..Sodium restriction is commonly recommended as a measure to lower blood pressure and thus reduce cardiovascular disease (CVD) and all-cause mortality. However, some studies have observed higher mortality associated with lower sodium intake...
- Increased dietary sodium alters Fos expression in the lamina terminalis during intravenous angiotensin II infusionSteven L Bealer
Department of Pharmacology and Toxicology, College of Pharmacy, 20 South 3000 East, Rm 201, University of Utah, Salt Lake City, UT 84121, USA
Exp Neurol 204:299-306. 2007These studies examined the effects of increased dietary sodium on expression of Fos, the protein product of c-fos, in forebrain structures in the rat following intravenous infusion with angiotensin II (AngII)...
- High-salt diet induces gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pylori colonization in C57BL/6 miceJ G Fox
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA
Cancer Res 59:4823-8. 1999..pylori colonization. Furthermore, elevated salt intake may potentiate H. pylori-associated carcinogenesis by inducing proliferation, pit cell hyperplasia, and glandular atrophy...
- Dietary sodium as a risk factor for osteoporosis: where is the evidence?Birgit Teucher
Nutrition Division, Institute of Food Research, Norwich NR4 7UA, UK
Proc Nutr Soc 62:859-66. 2003..g. salt sensitivity). The reasons for inter-individual variability should be explored using post-genomic techniques...
- Role of dietary sodium in osteoporosisRobert P Heaney
Creighton University, Omaha, Nebraska 68178, USA
J Am Coll Nutr 25:271S-276S. 2006..Given the relative difficulty of the former, and the ancillary benefits of the latter, it would seem that the optimal strategy to protect the skeleton is to ensure adequate calcium and potassium intakes...
- A further subgroup analysis of the effects of the DASH diet and three dietary sodium levels on blood pressure: results of the DASH-Sodium TrialGeorge A Bray
Pennington Biomedical Research Center, Baton Rouge, Lousiana, USA
Am J Cardiol 94:222-7. 2004....
- Reducing dietary sodium and decreases in cardiovascular disease in CanadaErika D Penz
Department of Medicine, University of Calgary, Calgary, Alberta
Can J Cardiol 24:497-1. 2008Increases in dietary sodium increase blood pressure, whereas emerging evidence confirms that the reduction in dietary sodium results in reduced cardiovascular events.
- Effect of renin-angiotensin system activation by dietary sodium restriction and upright position on plasma leptin concentration in patients with essential hypertensionMarcin Adamczak
Department of Nephrology, Endocrinology and Metabolic Diseases, Silesian Medical University, Katowice, Poland
Med Sci Monit 8:CR473-7. 2002..containing 100-120 mmol sodium per day and after 8 hours overnight bed rest, and a second time after 3 days of dietary sodium restriction (10-20 mmol daily) and 3 hours in upright position...
- Dietary sodium intake and subsequent risk of cardiovascular disease in overweight adultsJ He
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
JAMA 282:2027-34. 1999b>Dietary sodium is positively associated with blood pressure, and ecological and animal studies both have suggested that high dietary sodium intake increases stroke mortality.
- Renal denervation chronically lowers arterial pressure independent of dietary sodium intake in normal ratsFrederic Jacob
Department of Physiology, Lillehei Heart Institute, University of Minnesota, Minneapolis 55455, USA
Am J Physiol Heart Circ Physiol 284:H2302-10. 2003..Overall, there were no between-group differences in sodium or water balance in either protocol. We conclude that renal nerves support basal levels of AP, irrespective of dietary sodium intake in normal rats.
- Reducing dietary sodium intake: the Canadian contextSusan I Barr
Food, Nutrition, and Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
Appl Physiol Nutr Metab 35:1-8. 2010..men and two thirds of Canadian women have sodium intakes above the UL, Health Canada's Working Group on Dietary Sodium Reduction has been charged with developing, implementing, and overseeing a strategy to reduce Canadians' ..
- Blood pressure response to changes in sodium and potassium intake: a metaregression analysis of randomised trialsJ M Geleijnse
Division of Human Nutrition and Epidemiology, Wageningen University, The Netherlands
J Hum Hypertens 17:471-80. 2003..51 vs -0.34 mmHg, P=0.074). In conclusion, reduced intake of sodium and increased intake of potassium could make an important contribution to the prevention of hypertension, especially in populations with elevated blood pressure...
- Dietary sodium and target organ damage in essential hypertensionGuilhem du Cailar
Department of Internal Medicine and Hypertension, Hopital Lapeyronie, Montpellier, France
Am J Hypertens 15:222-9. 2002In addition to its widely contested influence on arterial pressure, dietary sodium may exert some nonpressure-related effects on left ventricular mass in humans...
- Sodium intake affects urinary albumin excretion especially in overweight subjectsJ C Verhave
Division of Nephrology, Department of Medicine, University Medical Center Groningen, Groningen University Institute of Drug Exploration (GUIDE, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
J Intern Med 256:324-30. 2004..RESULTS: The results show a positive relationship between dietary sodium intake and urinary albumin excretion...
- Changes in dietary sodium consumption modulate GLUT4 gene expression and early steps of insulin signalingMaristela Mitiko Okamoto
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 1524 05508-900, , Brazil
Am J Physiol Regul Integr Comp Physiol 286:R779-85. 2004..In the present study we investigated the influence of dietary sodium on 1) GLUT4 gene expression, by No the n and Western blotting analysis; 2) in vivo GLUT4 protein translocation,..
- The dietary sodium-blood pressure plot "stiffens"Alexei Y Bagrov
Hypertension 44:22-4. 2004
- Dietary sodium restriction rapidly improves large elastic artery compliance in older adults with systolic hypertensionPhillip E Gates
Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
Hypertension 44:35-41. 2004We determined the temporal effects of dietary sodium restriction on large elastic artery compliance and systolic blood pressure (SBP) in 12 untreated, older (64+/-2 years) men and women (6 each) with stage 1 systolic hypertension...
- Dietary sodium: the dark horse amongst cardiovascular and renal risk factorsAlbert Mimran
Department of Internal Medicine, , Montpellier Cedex, France
Nephrol Dial Transplant 23:2138-41. 2008
- Reducing the public health burden from elevated blood pressure levels in the United States by lowering intake of dietary sodiumStephen Havas
Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, 21201, USA
Am J Public Health 94:19-22. 2004..Such a reduction would greatly enhance the chances of attaining the Healthy People 2010 objectives and would save at least 150 000 lives annually. This issue warrants public health intervention...
- Dietary sodium intake regulates the ubiquitin-protein ligase nedd4-2 in the renal collecting systemDominique Loffing-Cueni
University of Fribourg, Department of Medicine Anatomy, Route Albert Gockel 1, CH 1700 Fribourg, Switzerland
J Am Soc Nephrol 17:1264-74. 2006..It is concluded that Nedd4-2 abundance is regulated by Na(+) diet, by a mechanism that likely involves aldosterone. This regulation may contribute to adaptation of apical ENaC activity to altered Na(+) intake...
- Activated vitamin D attenuates left ventricular abnormalities induced by dietary sodium in Dahl salt-sensitive animalsNatalya Bodyak
Cardiovascular Division and Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 104:16810-5. 2007..In summary, PC attenuates the development of LV alterations in DSS rats, and these effects should be examined in human clinical trials...
- Evidence relating dietary sodium to cardiovascular diseaseMichael H Alderman
Albert Einstein College of Medicine, Dept of Epidemiology and Population Health, Bronx, New York 10461, USA
J Am Coll Nutr 25:256S-261S. 2006The expectation that dietary sodium intake might influence cardiovascular disease occurrence has been based upon its impact on blood pressure (BP)...
- Randomized trials of sodium reduction: an overviewJ A Cutler
Division of Epidemiology and Clinical Applications, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Am J Clin Nutr 65:643S-651S. 1997..The blood pressure reduction that would result from a substantial lowering of dietary sodium in the US population could reduce cardiovascular morbidity and mortality.
- Evidence-based politics of salt and blood pressureQais Al-Awqati
Kidney Int 69:1707-8. 2006
- Abnormal expression of ENaC and SGK1 mRNA induced by dietary sodium in Dahl salt-sensitively hypertensive ratsWataru Aoi
Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
Cell Biol Int 31:1288-91. 2007..the kidney of Dahl salt-sensitive (DS) rats was abnormally regulated by aldosterone, however it is unknown if dietary sodium affects the expression of ENaC and serum and glucocorticoid-regulated kinase 1 (SGK1), which plays an ..
- Dietary sodium intake and mortality: the National Health and Nutrition Examination Survey (NHANES I)M H Alderman
Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Lancet 351:781-5. 1998Population-wide restriction of dietary sodium has been recommended. However, little evidence directly links sodium intake to morbidity and mortality...
- Presidential Address: 21st Scientific Meeting of the International Society of Hypertension: dietary sodium and cardiovascular disease: the 'J'-shaped relationMichael H Alderman
Albert Einstein College of Medicine, Department of Epidemiology and Population Health, 1300 Morris Park Avenue, Bronx, New York 10461, USA
J Hypertens 25:903-7. 2007
- Extrarenal ETB plays a significant role in controlling cardiovascular responses to high dietary sodium in ratsMamoru Ohkita
Department of Pediatrics, University of Michigan, Ann Arbor 48109 0656, USA
Hypertension 45:940-6. 2005..caused by an absence of renal ET(B) signaling and performed a series of experiments to examine the effect of dietary sodium (Na) on endothelin-1 (ET1) expression and renal function in wild-type (WT) and ET(B)-deficient rats...
- Reducing the population burden of cardiovascular disease by reducing sodium intake: a report of the Council on Science and Public HealthBarry D Dickinson
American Medical Association, 515 N State St, Chicago, IL 60610, USA
Arch Intern Med 167:1460-8. 2007..In the continued absence of voluntary measures adopted by the food industry, new regulations will be required to achieve lower sodium concentrations in processed and prepared foods...
- Sodium intake and risk of death from stroke in Japanese men and womenChisato Nagata
Department of Epidemiology and Preventive Medicine, Gifu University School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
Stroke 35:1543-7. 2004..The purpose of this study was to examine the relation between sodium intake and death from stroke in a population-based cohort of Japanese men and women...
- Effects of dietary sodium and magnesium on cyclosporin A-induced hypertension and nephrotoxicity in spontaneously hypertensive ratsE M Mervaala
Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
Hypertension 29:822-7. 1997..In the present study, the effects of dietary sodium and magnesium on CsA toxicity were examined in spontaneously hypertensive rats...
- Effects of dietary sodium and genetic background on angiotensinogen and Renin in mousePierre Lantelme
Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City, USA
Hypertension 39:1007-14. 2002..The response of this tubular renin-angiotensin system to stepwise changes in dietary sodium was investigated in 2 mouse strains, the sodium-sensitive inbred C57BL/6 and the sodium-resistant CD1 outbred...
- The feasibility of implementing a dietary sodium reduction intervention among free-living normotensive individuals in south west NigeriaAdebowale A Adeyemo
College of Medicine, University of Ibadan, Nigeria
Ethn Dis 12:207-12. 2002..In this study, we tested the feasibility of achieving a reduction in dietary sodium intake in free-living individuals using a dietary intervention among 82 free-living normotensive adults in ..
- Neuronal responsiveness to central Na+ in 2 congenic strains of Dahl salt-sensitive ratsBing S Huang
University of Ottawa Heart Institute, Ottawa, Ontario, Canada
Hypertension 49:1315-20. 2007..However, neither of them contributes to the increase in cerebrospinal fluid [Na(+)] induced by high salt...
- The contribution of brain angiotensin II to the baroreflex regulation of renal sympathetic nerve activity in conscious normotensive and hypertensive ratsChunlong Huang
Department of Physiology, Aras Windle, University College Cork, Cork, Republic of Ireland
J Physiol 574:597-604. 2006..indicate that in the conscious state, the tonic inhibitory action of brain angiotensin II on the baroreflex regulation of renal sympathetic nerve activity was unaffected by raised dietary sodium, but its role was enhanced in the SHRSPs.
- Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channelKiyoshi Nakagawa
Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
J Clin Invest 116:1696-702. 2006..It is expected that these results could lead to new strategies for the early diagnosis and clinical management of this devastating disease...
- Chronic blockade of neuronal nitric oxide synthase does not affect long-term control of blood pressure in normal, saline-drinking or deoxycorticosterone-treated ratsRosemary Wangensteen
, Facultad de Medicina, , Unidad Experimental, Hospital Virgen de las Nieves, Granada, Spain
Exp Physiol 88:243-50. 2003..Furthermore, the nNOS blockade does not interfere with the counterbalance between renin and an increased sodium intake or retention...
- Circulating coupling factor 6 in human hypertension: role of reactive oxygen speciesTomohiro Osanai
Second Deparment of Internal Medicine, Hirosaki University School of Medicine, Japan
J Hypertens 21:2323-8. 2003..Coupling factor 6 is an endogenous inhibitor of prostacyclin synthesis and might function as an endogenous vasoconstrictor in the fashion of a circulating hormone in rats. We investigated the role of coupling factor 6 in human hypertension...
- The impact of daily sodium intake on posttransplant hypertension in kidney allograft recipientsK Keven
Ankara University School of Medicine, Department of Nephrology, Ankara, Turkey
Transplant Proc 38:1323-6. 2006..Although dietary sodium restriction is a widely recommended nonpharmacological measure for control of blood pressure (BP), no detailed ..
- Negative regulators of sodium transport in the kidney: key factors in understanding salt-sensitive hypertension?Bernard C Rossier
Institut de Pharmacologie et de Toxicologie, Universite de Lausanne, Lausanne, Switzerland
J Clin Invest 111:947-50. 2003
- The in vivo effects of Tulbhagia violacea on blood pressure in a salt-sensitive rat modelIrene Mackraj
Pfizer Molecular Biology Research Facility, University of KwaZulu Natal, Durban 4000, South Africa
J Ethnopharmacol 117:263-9. 2008..The in vivo effects of Tulbhagia violacea on systemic arterial blood pressure and on the renin-angiotensin system in a Dahl salt-sensitive rat model were investigated...
- Role of AT1 and AT2 receptor subtypes in salt-sensitive hypertension induced by sensory nerve degenerationY Huang
Department of Medicine, Michigan State University, East Lansing, Michigan 48824, USA
J Hypertens 19:1841-6. 2001..Furthermore, PD 123319 attenuates the development of hypertension in salt-loaded rats neonatally treated with capsaicin, indicating that the AT2 receptor contributes to the increase in blood pressure...
- Prevention of salt-induced hypertension and fibrosis by AT1-receptor blockers in Dahl S ratsBinhui Liang
From the Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
J Cardiovasc Pharmacol 51:457-66. 2008..In Dahl S rats, AT1-receptor stimulation seems to play a critical role in salt-induced hypertension and fibrosis, but a lesser role in tissue hypertrophy...
- Enhanced sodium sensitivity and disturbed circadian rhythm of blood pressure in essential hypertensionTakashi Uzu
Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
J Hypertens 24:1627-32. 2006....
- Salt sensitivity: a consequence of the metabolic syndrome?Olle Melander
J Hypertens 24:1475-7. 2006
- Salt and hypertension: a phylogenetic perspectiveArye Lev-Ran
Maccabi Health Services, Petah-Tikva, Israel
Diabetes Metab Res Rev 21:118-31. 2005....
- Renal interstitial Ca2+ during sodium loading of normotensive and Dahl-salt hypertensive ratsCassandra E Palmer
Cardiovascular Disease Research Program, Biomedical/Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA
Am J Hypertens 16:771-6. 2003....
- Investigation of aldosterone-synthase inhibition in ratsJoël Ménard
INSERM U652, Paris, France
J Hypertens 24:1147-55. 2006..In-vivo investigation of aldosterone-synthase inhibitors requires experimental models to characterize the biological effects of these compounds...
- G-protein beta-3 subunit gene C825 T polymorphism: influence on plasma sodium and potassium concentrations in essential hypertensive patientsDolores Nieto Martín
Unidad de Hipertensión Arterial y Lípidos, Servicio de Medicina Interna, Hospitales Universitarios Virgen del Rocio, Avenida Manuel Siurot s n, 41013 Sevilla, Spain
Life Sci 77:2879-86. 2005....
- [Abnormalities of renal sodium transport and blood pressure sensitivity to salt]M Burnier
Service de Néphrologie et Hypertension, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 17, 1011 Lausanne, Switzerland
Nephrol Ther 3:S94-8. 2007..There is now also extending experimental, clinical, genetic and epidemiological evidence suggesting that proximal tubular function is an important determinant of the blood pressure response to salt that would deserve a greater attention...
- Plasma sodium: ignored and underestimatedFeng J He
Blood Pressure Unit, St. George's Hospital Medical School, London, UK
Hypertension 45:98-102. 2005..Small changes in plasma sodium alter extracellular volume, which may influence blood pressure. Changes in plasma sodium may also affect blood pressure directly...
- [Renin-angiotensin-aldosterone system and natriuretic peptide system--reference to cardiovascular diseases]Hirofumi Yasue
Kumamoto Aging Research Institute
Nippon Rinsho 62:164-9. 2004
- Low-dose lithium combined with captopril prevents stroke and improves survival in salt-loaded, stroke-prone spontaneously hypertensive ratsJihong Xu
Institute of Pharmacology, University Hospital of Schleswig-Holstein, Campus Kiel, Germany
J Hypertens 23:2277-85. 2005..This effect was independent of a reduction in blood pressure...
- Diet and blood pressure in South Africa: Intake of foods containing sodium, potassium, calcium, and magnesium in three ethnic groupsKaren E Charlton
Chronic Diseases of Lifestyle Unit, Medical Research Council, Tygerberg, South Africa
Nutrition 21:39-50. 2005....
- Salt-sensitive blood pressure in mice with increased expression of aldosterone synthaseNatalia Makhanova
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 701 Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
Hypertension 51:134-40. 2008....
- Sodium and potassium in the pathogenesis of hypertensionHoracio J Adrogue
Department of Medicine, Baylor College of Medicine, Houston, USA
N Engl J Med 356:1966-78. 2007
- Pulse-pressure-driven neutral lipid accumulation and correlative proinflammatory markers of accelerated atherogenesisCharles R Kiefer
Department of Hospital Laboratories, UMass Memorial Medical Center, One Biotech Park, Suite 200, 365 Plantation Street, Worcester, MA 01605 2376, USA
Atherosclerosis 183:17-24. 2005..weaning on a high-saturated fat, high-cholesterol diet until early adolescence (age 12 weeks), at which point dietary sodium was increased, and changes in blood pressure, serum analytes and histologic markers were tracked...
- Effects of changes in sodium balance on plasma and kidney angiotensin II levels in anesthetized and conscious Ren-2 transgenic ratsZuzana Husková
Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
J Hypertens 24:517-27. 2006....
- [Promoter variants of aldosterone synthase gene (CYP11B2) and salt-sensitivity of blood pressure]Agnieszka Wrona
Samodzielna Pracownia Patobiochemii i Biologii Molekularnej Pomorskiej AM w Szczecinie
Pol Arch Med Wewn 111:191-7. 2004..Our preliminary results suggest the lack of association of the T(-344)C CYP11B2 polymorphism with salt-sensitive hypertension as well as with activity of plasma renin-angiotensin-aldosterone system in Caucasian patients...
- Congenic strains reveal the effect of the renin gene on skeletal muscle angiogenesis induced by electrical stimulationMicheline M de Resende
Biotechnology and Bioengineering Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Physiol Genomics 33:33-40. 2008..The present study emphasizes the importance of maintaining normal renin regulation as well as ANG II levels during the angiogenesis process with a combination of physiological, genetic, and pharmacological manipulation of the RAS...
- Uninephrectomy in young age or chronic salt loading causes salt-sensitive hypertension in adult ratsMattias Carlström
Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
Hypertension 49:1342-50. 2007..In conclusion, at a young age after completed nephrogenesis, uninephrectomy or chronic salt loading causes renal and cardiovascular injury with salt-sensitive hypertension...
- Hypertension, Na+/Ca2+ exchanger, and Na+, K+-ATPaseT Iwamoto
Department of Pharmacology, School of Medicine, Fukuoka University, Fukuoka, Japan
Kidney Int 69:2148-54. 2006..This proposed pathway may have enabled us to explain how to link dietary salt to hypertension...
- Dietary sodium and blood pressureDaniel W Jones
Office of the Vice Chancellor, University of Mississippi Medical Center, 2500 North State Street Jackson, MS 39216-4505, USA
Hypertension 43:932-5. 2004
- Sodium and potassium excretion in normotensive and hypertensive population in KashmirR A Jan
Department of Medicine, Sher-i-Kashmir Institute of Medical Sciences, Srinagar
J Assoc Physicians India 54:22-6. 2006..20) in patients with hypertension. Thus sodium and potassium excretion, Na+-K+ molar ratio and body mass index has direct bearing in perpetuation or causation of hypertension in Kashmir which may be related to intake of salt tea...
- A missing link between a high salt intake and blood pressure increaseMakoto Katori
Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, Japan
J Pharmacol Sci 100:370-90. 2006..Furthermore, pharmaceutical development of renal kallikrein releasers, such as K(ATP) channel blockers, and renal kininase inhibitors, such as ebelactone B, may lead to the development of novel antihypertensive drugs...
- [Salt restriction in treatment of diabetes mellitus]Masahiro Motokawa
Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences
Nippon Rinsho 63:417-23. 2005
- Dopaminergic modulation of aldosterone secretions on changes of sodium intake in aldosterone-producing adenomaKwan-Dun Wu
Department of Internal Medicine, National Taiwan University Hospital, Taipei
Am J Hypertens 15:609-14. 2002..On HS, the nonsuppressible subjects, with less dopaminergic inhibition of aldosterone secretion, had less urinary DA excretion and greater BP elevation. The renal and adrenal dopaminergic activities are regulated in a parallel fashion...
- Chronic activation of plasma renin is log-linearly related to dietary sodium and eliminates natriuresis in response to a pulse change in total body sodiumMads Kjolby
Department of Physiology and Pharmacology, Institute of Medical Biology, University of Southern Denmark, Odense, Denmark
Am J Physiol Regul Integr Comp Physiol 294:R17-25. 2008..RAAS variables are log-linearly related to sodium intake over a >250-fold range in sodium intake, defining dietary sodium function lines that are simple measures of the sodium sensitivity of the RAAS...
- Low-renin hypertension, altered sodium homeostasis, and an alpha-adducin polymorphismFrederick D Grant
Endocrinology Hypertension Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Hypertension 39:191-6. 2002..2%) were homozygous for the 460Trp allele. The systolic blood pressure response to changes in dietary sodium was significantly greater in subjects homozygous for the 460Trp allele (25 +/- 4 mm Hg) compared with subjects ..
- Role of angiotensin converting enzyme genotype in sodium sensitivity in older hypertensivesD R Dengel
School of Kinesiology and Leisure Studies, University of Minnesota, Minneapolis 55455, USA
Am J Hypertens 14:1178-84. 2001Individuals differ in their blood pressure (BP) response to changes in dietary sodium (Na+) intake. It is possible that differences in BP responses to dietary Na+ are influenced by genes.
- Role of renin-angiotensin-aldosterone system in salt-sensitive hypertension induced by sensory denervationY Huang
Department of Medicine, Michigan State University, East Lansing, Michigan 48824, USA
Am J Physiol Heart Circ Physiol 281:H2143-9. 2001..Therefore, insufficiently suppressed PRA and PAL in response to HS intake by sensory denervation may contribute to increased salt sensitivity and account for effectiveness of spironolactone in lowering blood pressure in this model...
- Renal and hormonal responses to direct renin inhibition with aliskiren in healthy humansNaomi D L Fisher
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Circulation 117:3199-205. 2008..We predicted that blockade with the direct oral renin inhibitor aliskiren would produce renal vascular responses exceeding those induced by angiotensin-converting enzyme inhibitors and angiotensin receptor blockers...
- Salt-sensitive hypertension in ANP knockout mice: potential role of abnormal plasma renin activityL G Melo
Department of Physiology, University of Toronto, Ontario, Canada
Am J Physiol 274:R255-61. 1998....
- Role of the renin-angiotensin system during alterations of sodium intake in conscious miceB C Cholewa
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Am J Physiol Regul Integr Comp Physiol 281:R987-93. 2001..These studies indicate that the physiological suppression of circulating ANG II may be required to maintain a constancy of arterial pressure during alterations in sodium intake in normal mice...
- Renal endothelin ET(A)/ET(B) receptor imbalance differentiates salt-sensitive from salt-resistant spontaneous hypertensionL Rothermund
, Benjamin Franklin Hospital, , Berlin, Germany
Hypertension 37:275-80. 2001..05). Thus, activation of the renal ET system together with an increased ET(A)/ET(B) receptor ratio may contribute to the development and progression of SS-SH...
- [Recent trends in studies of the etiology of hypertension: Renal mechanism of blood pressure regulation]S Ito
Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Tohoku University School of Medicine
Nippon Rinsho 59:872-7. 2001..mechanism, hypertension can be classified as salt-sensitive or non-salt-sensitive based on the response to dietary sodium loading...
- Coordinate regulation of canine glomeruli and adrenal angiotensin receptors by dietary sodium manipulationW Zheng
Division of Nephrology and Hypertension, Department of Medicine, Georgetown University, Washington DC 20007-2145, USA
Kidney Int 59:1881-90. 2001BACKGROUND: This study evaluated the effects of dietary sodium manipulation in dogs on the regulation of canine angiotensin receptors (cAT1 and cAT2) in the kidney and adrenal...
- [Sodium and hypertension]H E De Wardener
Department of Chemical Pathology, Charing Cross and Westminster Medical School, London
Arch Mal Coeur Vaiss 89:9-15. 1996..Essential hypertension would appear to be as much a renal disturbance related to the intake of sodium as hypertension secondary to renal disease...
- New salt-sensitivity metrics: variability-adjusted blood pressure change and the urinary sodium-to-creatinine ratioJohn M Flack
Department of Internal Medicine, Wayne State University School of Medicine and the Detroit Medical Center, Michigan 48201, USA
Ethn Dis 12:10-9. 2002..Estimated 24-hour urinary sodium excretion was 133.6 mmol; the average urinary sodium-to-creatinine ratio was 0.74...
- The occurrence of parathyroid hypertensive factor (PHF) in Dahl ratsR Z Lewanczuk
Department of Physiology, University of Alberta, Edmonton, Canada
Am J Hypertens 6:758-62. 1993..50, P = .0077). These results show that Dahl-S rats are capable of expressing PHF-like activity, which is induced by increasing dietary salt intakes.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Role of cyclooxygenase-2 in the prolonged regulation of renal functionFrancisco Roig
, Facultad de Medicina, Murcia, Spain
Hypertension 40:721-8. 2002....
- Plasma sodium-potassium ATPase inhibition activity in low- and normal-renin hypertensionP Keane
Foothills Provincial General Hospital, Faculty of Medicine, University of Calgary, Alberta, Canada
Am J Hypertens 4:9-13. 1991..384, P = .019). Plasma NKAIA is related to mean arterial pressure or urinary sodium excretion depending on the dietary sodium intake, and is related to sodium-induced changes in MAP in low and normal renin hypertensive patients.
- Sodium and Cardiovascular Disease in Patients with Chronic Kidney DiseaseJiang He; Fiscal Year: 2010..The few prospective epidemiologic studies that examined the relationship between dietary sodium and potassium intake and risk of CVD provided contradictory findings...
- Sodium and Cardiovascular Disease in Patients with Chronic Kidney DiseaseJiang He; Fiscal Year: 2009..The few prospective epidemiologic studies that examined the relationship between dietary sodium and potassium intake and risk of CVD provided contradictory findings...
- HYPERTENSION IN POPULATIONS OF WEST AFRICAN ORIGINRichard Cooper; Fiscal Year: 2007..propose to examine in further detail the role of the two most potent hypertensive risk factors, namely dietary sodium and obesity...
- NITRIC OXIDE AND HEREDITARY LOW-RENIN HYPERTENSIONPaul Sanders; Fiscal Year: 1993..of salt-sensitive hypertension; 2) demonstrate modulation of NO production in response to changes in dietary sodium chloride intake and/or L-arginine and determine the role of NO and L-arginine on renal handling of sodium ..
- REVERSAL OF MYOCARDIAL HYPERTROPHY IN HYPERTENSIONSubha Sen; Fiscal Year: 1993..Influential factors are dietary sodium, catecholamines, and many pharmacological agents used as antihypertensive drugs...
- REVERSAL OF MYOCARDIAL HYPERTROPHY IN HYPERTENSIONSubha Sen; Fiscal Year: 2002..Influential factors are dietary sodium, catecholamines, and many pharmacological agents used as antihypertensive drugs...
- Beta2-Adrenergic Receptor Gene Variation and Cardiovascular Control in HumansJohn Eisenach; Fiscal Year: 2009..to sympathoexcitatory maneuvers like mental stress and handgrip, 2-mediated cardiac and vascular function, and dietary sodium manipulation...
- Beta2-Adrenergic Receptor Gene Variation and Cardiovascular Control in HumansJohn Eisenach; Fiscal Year: 2009..to sympathoexcitatory maneuvers like mental stress and handgrip, 2-mediated cardiac and vascular function, and dietary sodium manipulation...
- Beta2-Adrenergic Receptor Gene Variation and Cardiovascular Control in HumansJohn H Eisenach; Fiscal Year: 2010..to sympathoexcitatory maneuvers like mental stress and handgrip, 2-mediated cardiac and vascular function, and dietary sodium manipulation...
- INTRARENAL REGULATION OF SODIUM EXCRETIONJohn Burnett; Fiscal Year: 2004..Recognizing the increase of dietary sodium intake in the US, the hypothesis that dietary sodium excess contributes to progressive ventricular remodeling ..
- Degenerative Changes in the Taste SystemLYNNETTE MCCLUSKEY; Fiscal Year: 2007..Indeed, there is evidence that dietary sodium restriction is immunosuppressive...
- gamma-MSH and Sodium MetabolismMichael Humphreys; Fiscal Year: 2007Variations in dietary sodium intake initiate integrated adjustments in neural and hormonal systems regulating sodium excretion by the kidneys in order to maintain overall sodium balance...
- SODIUM INTAKE AND CALCIUM RETENTION IN ADOLESCENT GIRLSConnie Weaver; Fiscal Year: 2001..The primary aim of this proposal is to test the hypothesis that high dietary sodium increases the calcium intakes required for optimal calcium retention in both black and white adolescent girls...
- INTRARENAL REGULATION OF SODIUM EXCRETIONJohn Burnett; Fiscal Year: 2000..While dietary sodium restriction is employed as the first step in the treatment of CHF to limit sodium accumulation, we hypothesize ..
- REGULATION OF THICK ASCENDING LIMB ACID-BASE TRANSPORTDavid Good; Fiscal Year: 1993..the effects on individual membrane transporters of factors such as vasopressin, dietary sodium intake, and chronic metabolic acidosis that regulate transcellular bicarbonate absorption, III...
- Family-Based Genome-wide Association Study for Salt-Sensitivity of Blood PressureJiang He; Fiscal Year: 2010..to localize and identify genetic variants which determine an individual's blood pressure (BP) response to dietary sodium intake by conducting a two-stage genome-wide association (GWA) study using the data and DNA specimens ..
- A Family Partnership Intervention for Heart FailureSandra Dunbar; Fiscal Year: 2009..Patient variables and measures are dietary sodium (24-hour urinary sodium), medication adherence to HF drugs including angiotensin converting enzyme inhibitors ..
- NEURAL CONTROL OF FLUID HOMEOSTASIS IN HYPERTENSIONGregory Fink; Fiscal Year: 2001..This is particularly the case where dietary sodium chloride (salt) intake is high...
- VASOPRESSIN RECEPTOR AND HYPERTENSIONMarc Thibonnier; Fiscal Year: 1992..and DOCA-salt hypertensive models) of the regulation of both types of AVP receptors during alterations of dietary sodium intake, of circulating AVP concentration and of blood pressure...