dietary sodium

Summary

Summary: Sodium or sodium compounds used in foods or as a food. The most frequently used compounds are sodium chloride or sodium glutamate.

Top Publications

  1. ncbi Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group
    F M Sacks
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 344:3-10. 2001
  2. pmc Activated vitamin D attenuates left ventricular abnormalities induced by dietary sodium in Dahl salt-sensitive animals
    Natalya Bodyak
    Cardiovascular Division and Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 104:16810-5. 2007
  3. pmc Effects of dietary sodium reduction on blood pressure in subjects with resistant hypertension: results from a randomized trial
    Eduardo Pimenta
    Hypertension Unit, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Brisbane, QLD, Australia
    Hypertension 54:475-81. 2009
  4. ncbi Dietary sodium and the incidence of hypertension in the Chinese population: a review of nationwide surveys
    Zhiquan Liu
    Cardiovascular Division, Department of Internal Medicine, First Affiliated Hospital, Xi an Jiaotong University Medical School, Xi an, People s Republic of China
    Am J Hypertens 22:929-33. 2009
  5. ncbi A review of methods to measure dietary sodium intake
    Brooke Bentley
    Student College of Nursing, University of Kentucky, Lexington, KY, USA
    J Cardiovasc Nurs 21:63-7. 2006
  6. ncbi Blood pressure response to changes in sodium and potassium intake: a metaregression analysis of randomised trials
    J M Geleijnse
    Division of Human Nutrition and Epidemiology, Wageningen University, The Netherlands
    J Hum Hypertens 17:471-80. 2003
  7. doi Dietary sodium: the dark horse amongst cardiovascular and renal risk factors
    Albert Mimran
    Department of Internal Medicine, Hopital Lapeyronie, Montpellier Cedex, France
    Nephrol Dial Transplant 23:2138-41. 2008
  8. ncbi Sodium in the Finnish diet: II trends in dietary sodium intake and comparison between intake and 24-h excretion of sodium
    H Reinivuo
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Eur J Clin Nutr 60:1160-7. 2006
  9. ncbi ACE inhibition has adverse renal effects during dietary sodium restriction in proteinuric and healthy rats
    I Hamming
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen and University of Groningen, The Netherlands
    J Pathol 209:129-39. 2006
  10. pmc Effect of renin-angiotensin-aldosterone system inhibition, dietary sodium restriction, and/or diuretics on urinary kidney injury molecule 1 excretion in nondiabetic proteinuric kidney disease: a post hoc analysis of a randomized controlled trial
    Femke Waanders
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Kidney Dis 53:16-25. 2009

Detail Information

Publications245 found, 100 shown here

  1. ncbi Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group
    F M Sacks
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 344:3-10. 2001
    ..We studied the effect of different levels of dietary sodium, in conjunction with the Dietary Approaches to Stop Hypertension (DASH) diet, which is rich in vegetables, ..
  2. pmc Activated vitamin D attenuates left ventricular abnormalities induced by dietary sodium in Dahl salt-sensitive animals
    Natalya Bodyak
    Cardiovascular Division and Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 104:16810-5. 2007
    ..In summary, PC attenuates the development of LV alterations in DSS rats, and these effects should be examined in human clinical trials...
  3. pmc Effects of dietary sodium reduction on blood pressure in subjects with resistant hypertension: results from a randomized trial
    Eduardo Pimenta
    Hypertension Unit, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Brisbane, QLD, Australia
    Hypertension 54:475-81. 2009
    Observational studies indicate a significant relation between dietary sodium and level of blood pressure. However, the role of salt sensitivity in the development of resistant hypertension is unknown...
  4. ncbi Dietary sodium and the incidence of hypertension in the Chinese population: a review of nationwide surveys
    Zhiquan Liu
    Cardiovascular Division, Department of Internal Medicine, First Affiliated Hospital, Xi an Jiaotong University Medical School, Xi an, People s Republic of China
    Am J Hypertens 22:929-33. 2009
    ..High dietary salt consumption is considered a risk factor for hypertension...
  5. ncbi A review of methods to measure dietary sodium intake
    Brooke Bentley
    Student College of Nursing, University of Kentucky, Lexington, KY, USA
    J Cardiovasc Nurs 21:63-7. 2006
    With the rising prevalence of heart failure, it is imperative to investigate reasons for dietary sodium nonadherence and to develop evidence-based interventions to promote adherence...
  6. ncbi Blood pressure response to changes in sodium and potassium intake: a metaregression analysis of randomised trials
    J M Geleijnse
    Division of Human Nutrition and Epidemiology, Wageningen University, The Netherlands
    J Hum Hypertens 17:471-80. 2003
    ..51 vs -0.34 mmHg, P=0.074). In conclusion, reduced intake of sodium and increased intake of potassium could make an important contribution to the prevention of hypertension, especially in populations with elevated blood pressure...
  7. doi Dietary sodium: the dark horse amongst cardiovascular and renal risk factors
    Albert Mimran
    Department of Internal Medicine, Hopital Lapeyronie, Montpellier Cedex, France
    Nephrol Dial Transplant 23:2138-41. 2008
  8. ncbi Sodium in the Finnish diet: II trends in dietary sodium intake and comparison between intake and 24-h excretion of sodium
    H Reinivuo
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Eur J Clin Nutr 60:1160-7. 2006
    To estimate cross-sectional and long-term dietary sodium intakes and sources in Finland, and to evaluate the validity of 48-h recall to assess sodium intake.
  9. ncbi ACE inhibition has adverse renal effects during dietary sodium restriction in proteinuric and healthy rats
    I Hamming
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen and University of Groningen, The Netherlands
    J Pathol 209:129-39. 2006
    ..Further studies should elucidate the mechanisms underlying these observations and their impact on long-term renoprotection...
  10. pmc Effect of renin-angiotensin-aldosterone system inhibition, dietary sodium restriction, and/or diuretics on urinary kidney injury molecule 1 excretion in nondiabetic proteinuric kidney disease: a post hoc analysis of a randomized controlled trial
    Femke Waanders
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Kidney Dis 53:16-25. 2009
    ..We hypothesized that a decrease in proteinuria by using therapeutic interventions is associated with decreased urinary KIM-1 levels...
  11. ncbi A further subgroup analysis of the effects of the DASH diet and three dietary sodium levels on blood pressure: results of the DASH-Sodium Trial
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, Lousiana, USA
    Am J Cardiol 94:222-7. 2004
    ....
  12. ncbi Dietary sodium intake modulates myocardial relaxation responsiveness to angiotensin II
    Jonathan S Williams
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Transl Res 148:49-54. 2006
    b>Dietary sodium alters renovascular responsiveness to angiotensin II (Ang II) in normal subjects. Evidence supports a connection among dietary sodium, the rennin-angiotensin system, and myocardial function...
  13. ncbi The role of vasopressin in essential hypertension. Plasma levels and effects of the V1 receptor antagonist OPC-21268 during different dietary sodium intakes
    Y Kawano
    Division of Hypertension and Nephrology, National Cardiovascular Center, Osaka, Japan
    Am J Hypertens 10:1240-4. 1997
    ..Our results suggest that VP does not play an important role in mild essential hypertension through its action on the V1 receptors regardless of dietary sodium intake.
  14. ncbi Structural vascular changes in hypertension: role of angiotensin II, dietary sodium supplementation, and sympathetic stimulation, alone and in combination in rats
    G Simon
    Department of Medicine, VA Medical Center, Minneapolis, MN 55417, USA
    Hypertension 37:255-60. 2001
    Elevated circulating angiotensin (Ang) II levels, dietary sodium, and sympathetic stimulation are recurrent themes of hypertension research, but their in vivo interaction in physiologically meaningful doses has not been adequately ..
  15. pmc Knowledge, attitudes and behaviours related to dietary sodium among 35- to 50-year-old Ontario residents
    Sophia Papadakis
    Minto Prevention and Rehabilitation Centre, University of Ottawa Heart Institute, Ottawa, Ontario
    Can J Cardiol 26:e164-9. 2010
    Excessive consumption of dietary sodium is an important public health issue. Little is known about the knowledge, attitudes and behaviours related to sodium consumption among Canadians.
  16. ncbi Dietary sodium promotes increased water intake and urine volume in cats
    Amanda J Hawthorne
    Waltham Centre for Pet Nutrition, Waltham on the Wolds, Leicestershire, UK
    J Nutr 134:2128S-2129S. 2004
  17. ncbi High dietary sodium blunts affects of angiotensin-converting enzyme inhibition on vascular angiotensin I-to-angiotensin II conversion in rats
    Menno J A Kocks
    Department of Internal Medicine, Division of Nephrology, University of Groningen, The Netherlands
    J Cardiovasc Pharmacol 42:601-6. 2003
    ..To investigate whether high-dietary sodium-induced effects on vascular conversion of Ang I might be involved in the sodium-induced blunting of the ..
  18. ncbi Dietary sodium intake and its relation to human health: a summary of the evidence
    Alexander G Logan
    University of Toronto, Toronto, Canada
    J Am Coll Nutr 25:165-9. 2006
  19. ncbi Long-term effects of dietary sodium intake on cytokines and neurohormonal activation in patients with recently compensated congestive heart failure
    Gaspare Parrinello
    Department of Internal Medicine, University of Palermo, Italy
    J Card Fail 15:864-73. 2009
    ..A growing body of evidence suggests that the fluid accumulation plays a key role in the pathophysiology of heart failure (HF) and that the inflammatory and neurohormonal activation contribute strongly to the progression of this disorder...
  20. ncbi Reducing dietary sodium intake: the Canadian context
    Susan I Barr
    Food, Nutrition, and Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    Appl Physiol Nutr Metab 35:1-8. 2010
    ..men and two thirds of Canadian women have sodium intakes above the UL, Health Canada's Working Group on Dietary Sodium Reduction has been charged with developing, implementing, and overseeing a strategy to reduce Canadians' ..
  21. ncbi Clustering of endothelial markers of vascular damage in human salt-sensitive hypertension: influence of dietary sodium load and depletion
    C Ferri
    University La Sapienza, Chair of I Clinica Medica, Andrea Cesalpino Foundation, Departments of Experimental Medicine, A s, University of L Aquila, L Aquila, Italy
    Hypertension 32:862-8. 1998
    ..Our findings support the hypothesis that salt sensitivity is correlated with an increased risk for developing hypertension-related cardiovascular damage...
  22. ncbi Modulation by dietary sodium intake of melanocortin 3 receptor mRNA and protein abundance in the rat kidney
    Xi Ping Ni
    Division of Nephrology, San Francisco General Hospital, California, USA
    Am J Physiol Regul Integr Comp Physiol 290:R560-7. 2006
    ..001). No significant increase occurred in the cortex. The increase in MC3-R expression induced by dietary sodium was observed in inner medullary collecting duct (IMCD) cells isolated from the kidneys of HSD rats, suggesting ..
  23. ncbi Effect of dietary sodium chloride on gastro-oesophageal reflux: a randomized controlled trial
    Marissa C Aanen
    Gastrointestinal Research Unit, University Medical Center, Utrecht, The Netherlands
    Scand J Gastroenterol 41:1141-6. 2006
    ..The objective of this study was to investigate the effect of increased dietary NaCl intake on gastro-oesophageal reflux and reflux mechanisms...
  24. ncbi The influence of dietary sodium on blood pressure
    Norman K Hollenberg
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical Center, Boston, MA 02115, USA
    J Am Coll Nutr 25:240S-246S. 2006
    ..On the bright side, prognosis is improved substantially by the array of antihypertensive drugs available today...
  25. ncbi Effects of dietary sodium and magnesium on cyclosporin A-induced hypertension and nephrotoxicity in spontaneously hypertensive rats
    E M Mervaala
    Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
    Hypertension 29:822-7. 1997
    ..In the present study, the effects of dietary sodium and magnesium on CsA toxicity were examined in spontaneously hypertensive rats...
  26. ncbi High dietary sodium intake increases white adipose tissue mass and plasma leptin in rats
    Miriam H Fonseca-Alaniz
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 1524 Prof Lineu Prestes Ave, 05508 900, Sao Paulo, SP, Brazil
    Obesity (Silver Spring) 15:2200-8. 2007
    ..Salt restriction has been reported to increase white adipose tissue (WAT) mass in rodents. The objective of this study was to investigate the effect of different sodium content diets on the lipogenic and lipolytic activities of WAT...
  27. ncbi Influence of an enriched dietary sodium chloride regime during gestation and suckling and post-natally on the ontogeny of hypertension in the rat
    N Hazon
    Department of Zoology, University of Sheffield, UK
    J Hypertens 6:517-24. 1988
    ..abstract truncated at 250 words)..
  28. pmc Dietary sodium effects on heart rate variability in salt sensitivity of blood pressure
    Jessica D McNeely
    Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    Psychophysiology 45:405-11. 2008
    High dietary sodium intake is a risk factor for hypertension, and heart rate variability (HRV) is decreased in hypertension. Effects of dietary sodium intake on HRV of normotensive persons have not, however, been investigated to date...
  29. pmc Effects of aging and alterations in dietary sodium intake on total nitric oxide production
    R J Schmidt
    Departments of Medicine and Physiology, West Virginia University, Morgantown, WV 26506, USA
    Am J Kidney Dis 37:900-8. 2001
    ..Limitations of blood and urine measurements of NO(2) + NO(3) and cGMP as indices of NO activity are discussed...
  30. ncbi Dietary sodium deprivation evokes activation of brain regional neurons and down-regulation of angiotensin II type 1 receptor and angiotensin-convertion enzyme mRNA expression
    B Lu
    Department of Physiology and Pathophysiology, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, School of Medicine, Xi an Jiaotong University, 76 W Yanta Road, Xi an, 710061, PR China
    Neuroscience 164:1303-11. 2009
    ..system (RAAS) is implicated in the induction of sodium appetite in rats and that different dietary sodium intakes influence the mRNA expression of central and peripheral RAAS components...
  31. ncbi Changes in urinary stone risk factors in hypocitraturic calcium oxalate stone formers treated with dietary sodium supplementation
    Marshall L Stoller
    Department of Urology, School of Medicine, University of California San Francisco, San Francisco, California, USA
    J Urol 181:1140-4. 2009
    We investigated the effects of supplemental dietary sodium on risk factors for urinary stone disease in stone forming patients with hypocitraturia.
  32. ncbi How far should salt intake be reduced?
    Feng J He
    Blood Pressure Unit, St George s Hospital Medical School, Cranmer Terrace, London, England
    Hypertension 42:1093-9. 2003
    ..A further reduction to 3 g/d will have a much greater effect and should now become the long-term target for population salt intake worldwide...
  33. pmc Estimate of the benefits of a population-based reduction in dietary sodium additives on hypertension and its related health care costs in Canada
    Michel R Joffres
    Simon Fraser University, Burnaby, British Columbia, Canada
    Can J Cardiol 23:437-43. 2007
    ..Reductions in dietary sodium additives significantly lower systolic and diastolic blood pressure, and population reductions in dietary ..
  34. pmc Surface expression of sodium channels and transporters in rat kidney: effects of dietary sodium
    Gustavo Frindt
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY 10065, USA
    Am J Physiol Renal Physiol 297:F1249-55. 2009
    ..We conclude that cleavage of gamma-ENaC and its expression at the apical surface play a major role in the regulation of renal Na reabsorption...
  35. ncbi The dietary sodium-blood pressure plot "stiffens"
    Alexei Y Bagrov
    Hypertension 44:22-4. 2004
  36. ncbi Extrarenal ETB plays a significant role in controlling cardiovascular responses to high dietary sodium in rats
    Mamoru Ohkita
    Department of Pediatrics, University of Michigan, Ann Arbor 48109 0656, USA
    Hypertension 45:940-6. 2005
    ..caused by an absence of renal ET(B) signaling and performed a series of experiments to examine the effect of dietary sodium (Na) on endothelin-1 (ET1) expression and renal function in wild-type (WT) and ET(B)-deficient rats...
  37. ncbi Urinary sodium excretion and cardiovascular mortality in Finland: a prospective study
    J Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Lancet 357:848-51. 2001
    ..We aimed to find out whether salt intake, measured by 24 h urinary sodium excretion, is an independent risk factor for cardiovascular disease frequency and mortality, and all-cause mortality...
  38. pmc Heritability of blood pressure responses to dietary sodium and potassium intake in a Chinese population
    Dongfeng Gu
    Cardiovascular Institute and Fu Wai Hospital, Beijing, China
    Hypertension 50:116-22. 2007
    ..We examined the heritability of blood pressure responses to dietary sodium and potassium intake in a family feeding study among 1906 study participants living in rural North China...
  39. ncbi Benefits of and barriers to dietary sodium adherence
    Janet L Welch
    Indiana University School of Nursing, Indianapolis, USA
    West J Nurs Res 28:162-80; discussion 181-9. 2006
    Failure to limit dietary sodium leads to thirst, large fluid weight gain, and poor outcomes in patients receiving hemodialysis...
  40. ncbi Dietary sodium intake and subsequent risk of cardiovascular disease in overweight adults
    J He
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
    JAMA 282:2027-34. 1999
    b>Dietary sodium is positively associated with blood pressure, and ecological and animal studies both have suggested that high dietary sodium intake increases stroke mortality.
  41. ncbi Effect of renin-angiotensin system activation by dietary sodium restriction and upright position on plasma leptin concentration in patients with essential hypertension
    Marcin Adamczak
    Department of Nephrology, Endocrinology and Metabolic Diseases, Silesian Medical University, Katowice, Poland
    Med Sci Monit 8:CR473-7. 2002
    ..This study was undertaken to assess the relationship between RAS and plasma leptin concentration in hypertensive patients under conditions of normal and restricted sodium supply and upright position...
  42. ncbi Dietary sodium as a risk factor for osteoporosis: where is the evidence?
    Birgit Teucher
    Nutrition Division, Institute of Food Research, Norwich NR4 7UA, UK
    Proc Nutr Soc 62:859-66. 2003
    ..g. salt sensitivity). The reasons for inter-individual variability should be explored using post-genomic techniques...
  43. ncbi Sodium intake and risk of death from stroke in Japanese men and women
    Chisato Nagata
    Department of Epidemiology and Preventive Medicine, Gifu University School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Stroke 35:1543-7. 2004
    ..The purpose of this study was to examine the relation between sodium intake and death from stroke in a population-based cohort of Japanese men and women...
  44. ncbi Effect of dietary sodium intake on blood lipids: results from the DASH-sodium trial
    David W Harsha
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Hypertension 43:393-8. 2004
    ..There were no significant interactions between the effects of sodium and the DASH diet on serum lipids. In conclusion, changes in dietary sodium intake over the range of 50 to 150 mmol/d did not affect blood lipid concentrations.
  45. ncbi Long-term effects of weight loss and dietary sodium reduction on incidence of hypertension
    J He
    Department of Epidemiology, the Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112 2699, USA
    Hypertension 35:544-9. 2000
    To examine the long-term effects of weight loss and dietary sodium reduction on the incidence of hypertension, we studied 181 men and women who participated in the Trials of Hypertension Prevention, phase 1, in Baltimore, Md...
  46. pmc Sodium intake and mortality follow-up in the Third National Health and Nutrition Examination Survey (NHANES III)
    Hillel W Cohen
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Gen Intern Med 23:1297-302. 2008
    ..Sodium restriction is commonly recommended as a measure to lower blood pressure and thus reduce cardiovascular disease (CVD) and all-cause mortality. However, some studies have observed higher mortality associated with lower sodium intake...
  47. pmc Reducing dietary sodium and decreases in cardiovascular disease in Canada
    Erika D Penz
    Department of Medicine, University of Calgary, Calgary, Alberta
    Can J Cardiol 24:497-1. 2008
    Increases in dietary sodium increase blood pressure, whereas emerging evidence confirms that the reduction in dietary sodium results in reduced cardiovascular events.
  48. ncbi Relations between dietary sodium and potassium intakes and mortality from cardiovascular disease: the Japan Collaborative Cohort Study for Evaluation of Cancer Risks
    Mitsumasa Umesawa
    Department of Public Health Medicine, Graduate School of Comprehensive Human Sciences, and the Institute of Community Medicine, University of Tsukuba, Tsukuba, Japan
    Am J Clin Nutr 88:195-202. 2008
    ..Limited evidence is available about the relations between sodium and potassium intakes and cardiovascular disease in the general population...
  49. ncbi Efficacy of nonpharmacologic interventions in adults with high-normal blood pressure: results from phase 1 of the Trials of Hypertension Prevention. Trials of Hypertension Prevention Collaborative Research Group
    P K Whelton
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University School of Hygiene and Public Health, Baltimore, USA
    Am J Clin Nutr 65:652S-660S. 1997
    ..These results suggest that both weight loss and sodium reduction provide an effective means to prevent hypertension. The long-term effects of both of these interventions are being tested in phase 2 of the trial...
  50. pmc Increased dietary sodium alters Fos expression in the lamina terminalis during intravenous angiotensin II infusion
    Steven L Bealer
    Department of Pharmacology and Toxicology, College of Pharmacy, 20 South 3000 East, Rm 201, University of Utah, Salt Lake City, UT 84121, USA
    Exp Neurol 204:299-306. 2007
    These studies examined the effects of increased dietary sodium on expression of Fos, the protein product of c-fos, in forebrain structures in the rat following intravenous infusion with angiotensin II (AngII)...
  51. ncbi Effect of aerobic exercise training on blood pressure sensitivity to dietary sodium in older hypertensives
    D R Dengel
    School of Kinesiology, University of Minnesota, Minneapolis, 55455, USA
    J Hum Hypertens 20:372-8. 2006
    ..exercise training has been shown to lower blood pressure (BP) in older adults, its effect on BP sensitivity to dietary sodium (Na(+)) is unknown...
  52. ncbi Renal denervation chronically lowers arterial pressure independent of dietary sodium intake in normal rats
    Frederic Jacob
    Department of Physiology, Lillehei Heart Institute, University of Minnesota, Minneapolis 55455, USA
    Am J Physiol Heart Circ Physiol 284:H2302-10. 2003
    ..Overall, there were no between-group differences in sodium or water balance in either protocol. We conclude that renal nerves support basal levels of AP, irrespective of dietary sodium intake in normal rats.
  53. ncbi Dietary sodium intake and mortality: the National Health and Nutrition Examination Survey (NHANES I)
    M H Alderman
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Lancet 351:781-5. 1998
    Population-wide restriction of dietary sodium has been recommended. However, little evidence directly links sodium intake to morbidity and mortality...
  54. ncbi Dietary sodium and target organ damage in essential hypertension
    Guilhem du Cailar
    Department of Internal Medicine and Hypertension, Hopital Lapeyronie, Montpellier, France
    Am J Hypertens 15:222-9. 2002
    In addition to its widely contested influence on arterial pressure, dietary sodium may exert some nonpressure-related effects on left ventricular mass in humans...
  55. ncbi Changes in dietary sodium consumption modulate GLUT4 gene expression and early steps of insulin signaling
    Maristela Mitiko Okamoto
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 1524 05508 900, Sao Paulo, Brazil
    Am J Physiol Regul Integr Comp Physiol 286:R779-85. 2004
    ..In the present study we investigated the influence of dietary sodium on 1) GLUT4 gene expression, by No the n and Western blotting analysis; 2) in vivo GLUT4 protein translocation,..
  56. ncbi Abnormal expression of ENaC and SGK1 mRNA induced by dietary sodium in Dahl salt-sensitively hypertensive rats
    Wataru Aoi
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Cell Biol Int 31:1288-91. 2007
    ..the kidney of Dahl salt-sensitive (DS) rats was abnormally regulated by aldosterone, however it is unknown if dietary sodium affects the expression of ENaC and serum and glucocorticoid-regulated kinase 1 (SGK1), which plays an ..
  57. ncbi Randomized trials of sodium reduction: an overview
    J A Cutler
    Division of Epidemiology and Clinical Applications, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Am J Clin Nutr 65:643S-651S. 1997
    ..The blood pressure reduction that would result from a substantial lowering of dietary sodium in the US population could reduce cardiovascular morbidity and mortality.
  58. ncbi Dietary sodium intake regulates the ubiquitin-protein ligase nedd4-2 in the renal collecting system
    Dominique Loffing-Cueni
    University of Fribourg, Department of Medicine Anatomy, Route Albert Gockel 1, CH 1700 Fribourg, Switzerland
    J Am Soc Nephrol 17:1264-74. 2006
    ..It is concluded that Nedd4-2 abundance is regulated by Na(+) diet, by a mechanism that likely involves aldosterone. This regulation may contribute to adaptation of apical ENaC activity to altered Na(+) intake...
  59. ncbi Evidence relating dietary sodium to cardiovascular disease
    Michael H Alderman
    Albert Einstein College of Medicine, Dept of Epidemiology and Population Health, Bronx, New York 10461, USA
    J Am Coll Nutr 25:256S-261S. 2006
    The expectation that dietary sodium intake might influence cardiovascular disease occurrence has been based upon its impact on blood pressure (BP)...
  60. pmc Reducing the public health burden from elevated blood pressure levels in the United States by lowering intake of dietary sodium
    Stephen Havas
    Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, 21201, USA
    Am J Public Health 94:19-22. 2004
    ..Such a reduction would greatly enhance the chances of attaining the Healthy People 2010 objectives and would save at least 150 000 lives annually. This issue warrants public health intervention...
  61. ncbi The feasibility of implementing a dietary sodium reduction intervention among free-living normotensive individuals in south west Nigeria
    Adebowale A Adeyemo
    College of Medicine, University of Ibadan, Nigeria
    Ethn Dis 12:207-12. 2002
    ..In this study, we tested the feasibility of achieving a reduction in dietary sodium intake in free-living individuals using a dietary intervention among 82 free-living normotensive adults in ..
  62. ncbi Influence of dietary sodium on the blood pressure and renal sympathetic nerve activity responses to intracerebroventricular angiotensin II and angiotensin III in anaesthetized rats
    Belinda L Houghton
    Department of Physiology, Windle Building, University College Cork, College Road, Cork, Republic of Ireland
    Exp Physiol 95:282-95. 2010
    ..c.v. AngII and AngIII; (2) highlight an important role for peripheral V(1) receptors during these responses; and (3) differentiate the effects of AngII and AngIII on blood pressure and RSNA...
  63. ncbi Presidential Address: 21st Scientific Meeting of the International Society of Hypertension: dietary sodium and cardiovascular disease: the 'J'-shaped relation
    Michael H Alderman
    Albert Einstein College of Medicine, Department of Epidemiology and Population Health, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    J Hypertens 25:903-7. 2007
  64. ncbi Dietary sodium intake and asthma: an epidemiological and clinical review
    T D Mickleborough
    Department of Kinesiology, Human Performance and Exercise Biochemistry Laboratory, Indiana University, Bloomington, Indiana 47401, USA
    Int J Clin Pract 60:1616-24. 2006
    ..factors that may have contributed to the rise in the prevalence of asthma over the past few decades, and dietary sodium has been considered to be a dietary constituent which may be implicated in this phenomenon...
  65. ncbi Role of dietary sodium in osteoporosis
    Robert P Heaney
    Creighton University, Omaha, Nebraska 68178, USA
    J Am Coll Nutr 25:271S-276S. 2006
    ..Given the relative difficulty of the former, and the ancillary benefits of the latter, it would seem that the optimal strategy to protect the skeleton is to ensure adequate calcium and potassium intakes...
  66. ncbi Evidence-based politics of salt and blood pressure
    Qais Al-Awqati
    Kidney Int 69:1707-8. 2006
  67. ncbi Central angiotensin modulation of baroreflex control of renal sympathetic nerve activity in the rat: influence of dietary sodium
    G F DiBona
    Department of Internal Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
    Acta Physiol Scand 177:285-9. 2003
    ..an intact blood-brain barrier to assess the role of endogenous angII of brain origin and (c) alterations in dietary sodium intake, a known physiological regulator of activity of the renin-angiotensin system (RAS), to assess the ..
  68. ncbi Sodium intake affects urinary albumin excretion especially in overweight subjects
    J C Verhave
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, Groningen University Institute of Drug Exploration GUIDE, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Intern Med 256:324-30. 2004
    ..To examine the relationship between sodium intake and urinary albumin excretion, being an established risk marker for later cardiovascular morbidity and mortality...
  69. ncbi Dietary sodium restriction rapidly improves large elastic artery compliance in older adults with systolic hypertension
    Phillip E Gates
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Hypertension 44:35-41. 2004
    We determined the temporal effects of dietary sodium restriction on large elastic artery compliance and systolic blood pressure (SBP) in 12 untreated, older (64+/-2 years) men and women (6 each) with stage 1 systolic hypertension...
  70. ncbi High-salt diet induces gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pylori colonization in C57BL/6 mice
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cancer Res 59:4823-8. 1999
    ..pylori colonization. Furthermore, elevated salt intake may potentiate H. pylori-associated carcinogenesis by inducing proliferation, pit cell hyperplasia, and glandular atrophy...
  71. ncbi Effects of dietary sodium and genetic background on angiotensinogen and Renin in mouse
    Pierre Lantelme
    Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City, USA
    Hypertension 39:1007-14. 2002
    ..The response of this tubular renin-angiotensin system to stepwise changes in dietary sodium was investigated in 2 mouse strains, the sodium-sensitive inbred C57BL/6 and the sodium-resistant CD1 outbred...
  72. ncbi Reducing the population burden of cardiovascular disease by reducing sodium intake: a report of the Council on Science and Public Health
    Barry D Dickinson
    American Medical Association, 515 N State St, Chicago, IL 60610, USA
    Arch Intern Med 167:1460-8. 2007
    ..In the continued absence of voluntary measures adopted by the food industry, new regulations will be required to achieve lower sodium concentrations in processed and prepared foods...
  73. ncbi Investigation of aldosterone-synthase inhibition in rats
    Joël Ménard
    INSERM U652, Paris, France
    J Hypertens 24:1147-55. 2006
    ..In-vivo investigation of aldosterone-synthase inhibitors requires experimental models to characterize the biological effects of these compounds...
  74. ncbi A missing link between a high salt intake and blood pressure increase
    Makoto Katori
    Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, Japan
    J Pharmacol Sci 100:370-90. 2006
    ..Furthermore, pharmaceutical development of renal kallikrein releasers, such as K(ATP) channel blockers, and renal kininase inhibitors, such as ebelactone B, may lead to the development of novel antihypertensive drugs...
  75. pmc The contribution of brain angiotensin II to the baroreflex regulation of renal sympathetic nerve activity in conscious normotensive and hypertensive rats
    Chunlong Huang
    Department of Physiology, Aras Windle, University College Cork, Cork, Republic of Ireland
    J Physiol 574:597-604. 2006
    ..indicate that in the conscious state, the tonic inhibitory action of brain angiotensin II on the baroreflex regulation of renal sympathetic nerve activity was unaffected by raised dietary sodium, but its role was enhanced in the SHRSPs.
  76. ncbi Sodium and potassium excretion in normotensive and hypertensive population in Kashmir
    R A Jan
    Department of Medicine, Sher I Kashmir Institute of Medical Sciences, Srinagar
    J Assoc Physicians India 54:22-6. 2006
    ..20) in patients with hypertension. Thus sodium and potassium excretion, Na+-K+ molar ratio and body mass index has direct bearing in perpetuation or causation of hypertension in Kashmir which may be related to intake of salt tea...
  77. ncbi Hypertension, Na+/Ca2+ exchanger, and Na+, K+-ATPase
    T Iwamoto
    Department of Pharmacology, School of Medicine, Fukuoka University, Fukuoka, Japan
    Kidney Int 69:2148-54. 2006
    ..This proposed pathway may have enabled us to explain how to link dietary salt to hypertension...
  78. pmc Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel
    Kiyoshi Nakagawa
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Clin Invest 116:1696-702. 2006
    ..It is expected that these results could lead to new strategies for the early diagnosis and clinical management of this devastating disease...
  79. ncbi Nonmodulating trait may precede the development of hypertension
    M S Gordon
    Endocrine-Hypertension Division, Brigham and Women's Hospital, Boston, Massachusetts 02115-5817
    Am J Hypertens 7:789-93. 1994
    ..We conclude that the nonmodulating trait may be a heritable defect that leads to the development of hypertension and is not an epiphenomenon...
  80. ncbi [Promoter variants of aldosterone synthase gene (CYP11B2) and salt-sensitivity of blood pressure]
    Agnieszka Wrona
    Samodzielna Pracownia Patobiochemii i Biologii Molekularnej Pomorskiej AM w Szczecinie
    Pol Arch Med Wewn 111:191-7. 2004
    ..Our preliminary results suggest the lack of association of the T(-344)C CYP11B2 polymorphism with salt-sensitive hypertension as well as with activity of plasma renin-angiotensin-aldosterone system in Caucasian patients...
  81. ncbi Low-dose lithium combined with captopril prevents stroke and improves survival in salt-loaded, stroke-prone spontaneously hypertensive rats
    Jihong Xu
    Institute of Pharmacology, University Hospital of Schleswig Holstein, Campus Kiel, Germany
    J Hypertens 23:2277-85. 2005
    ..In the present study, we investigated the effects of a low-dose combination treatment with lithium and captopril on survival and stroke prevention in salt-loaded, stroke-prone spontaneously hypertensive rats (SHRSP)...
  82. ncbi [Renin-angiotensin-aldosterone system and natriuretic peptide system--reference to cardiovascular diseases]
    Hirofumi Yasue
    Kumamoto Aging Research Institute
    Nihon Rinsho 62:164-9. 2004
  83. ncbi Plasma sodium: ignored and underestimated
    Feng J He
    Blood Pressure Unit, St George s Hospital Medical School, London, UK
    Hypertension 45:98-102. 2005
    ..Small changes in plasma sodium alter extracellular volume, which may influence blood pressure. Changes in plasma sodium may also affect blood pressure directly...
  84. ncbi Diet and blood pressure in South Africa: Intake of foods containing sodium, potassium, calcium, and magnesium in three ethnic groups
    Karen E Charlton
    Chronic Diseases of Lifestyle Unit, Medical Research Council, Tygerberg, South Africa
    Nutrition 21:39-50. 2005
    ....
  85. ncbi Salt and hypertension: a phylogenetic perspective
    Arye Lev-Ran
    Maccabi Health Services, Petah Tikva, Israel
    Diabetes Metab Res Rev 21:118-31. 2005
    ....
  86. ncbi Effects of changes in sodium balance on plasma and kidney angiotensin II levels in anesthetized and conscious Ren-2 transgenic rats
    Zuzana Husková
    Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    J Hypertens 24:517-27. 2006
    ....
  87. ncbi [Salt restriction in treatment of diabetes mellitus]
    Masahiro Motokawa
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences
    Nihon Rinsho 63:417-23. 2005
  88. ncbi G-protein beta-3 subunit gene C825 T polymorphism: influence on plasma sodium and potassium concentrations in essential hypertensive patients
    Dolores Nieto Martín
    Unidad de Hipertensión Arterial y Lípidos, Servicio de Medicina Interna, Hospitales Universitarios Virgen del Rocio, Avenida Manuel Siurot s n, 41013 Sevilla, Spain
    Life Sci 77:2879-86. 2005
    ....
  89. ncbi Pulse-pressure-driven neutral lipid accumulation and correlative proinflammatory markers of accelerated atherogenesis
    Charles R Kiefer
    Department of Hospital Laboratories, UMass Memorial Medical Center, One Biotech Park, Suite 200, 365 Plantation Street, Worcester, MA 01605 2376, USA
    Atherosclerosis 183:17-24. 2005
    ..weaning on a high-saturated fat, high-cholesterol diet until early adolescence (age 12 weeks), at which point dietary sodium was increased, and changes in blood pressure, serum analytes and histologic markers were tracked...
  90. ncbi The impact of daily sodium intake on posttransplant hypertension in kidney allograft recipients
    K Keven
    Ankara University School of Medicine, Department of Nephrology, Ankara, Turkey
    Transplant Proc 38:1323-6. 2006
    ..Although dietary sodium restriction is a widely recommended nonpharmacological measure for control of blood pressure (BP), no detailed ..
  91. ncbi Salt sensitivity: a consequence of the metabolic syndrome?
    Olle Melander
    J Hypertens 24:1475-7. 2006
  92. ncbi Enhanced sodium sensitivity and disturbed circadian rhythm of blood pressure in essential hypertension
    Takashi Uzu
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    J Hypertens 24:1627-32. 2006
    ....
  93. ncbi Long-term effect of nifedipine and hydrochlorothiazide on blood pressure and sodium homeostasis at varying levels of salt intake in mildly hypertensive patients
    F C Luft
    Department of Internal Medicine-Nephrology, , Germany
    Am J Hypertens 4:752-60. 1991
    ..The PRA appears inactivated, although not lowered. The effects of NIF on BP may be at least in part related to the natriuresis and blunting of PRA.(ABSTRACT TRUNCATED AT 250 WORDS)..
  94. ncbi Salt sensitivity of children with low birth weight
    Giacomo D Simonetti
    Department of Nephrology, Inselspital, Bern University Hospital, University of Bern, Berne, Switzerland
    Hypertension 52:625-30. 2008
    ..Whether the changes in renal growth are causative or are the consequence of the same abnormal "fetal programming" awaits clarification...
  95. ncbi Renin and aldosterone are higher and the hyperinsulinemic effect of salt restriction greater in subjects with risk factors clustering
    B M Egan
    Department of Pharmacology, Medical University of South Carolina, Charleston 29425
    Am J Hypertens 7:886-93. 1994
    ..Plasma renin activity also tended to increase more on the low salt diet in the high risk group. Ambulatory blood pressures were greater on the low than the high salt diet only in the high risk group.(ABSTRACT TRUNCATED AT 250 WORDS)..
  96. ncbi Renal and hormonal responses to direct renin inhibition with aliskiren in healthy humans
    Naomi D L Fisher
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Circulation 117:3199-205. 2008
    ..We predicted that blockade with the direct oral renin inhibitor aliskiren would produce renal vascular responses exceeding those induced by angiotensin-converting enzyme inhibitors and angiotensin receptor blockers...
  97. ncbi Salt-sensitive hypertension in ANP knockout mice: potential role of abnormal plasma renin activity
    L G Melo
    Department of Physiology, University of Toronto, Ontario, Canada
    Am J Physiol 274:R255-61. 1998
    ....
  98. ncbi Prevention of salt-induced hypertension and fibrosis by AT1-receptor blockers in Dahl S rats
    Binhui Liang
    From the Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Cardiovasc Pharmacol 51:457-66. 2008
    ..In Dahl S rats, AT1-receptor stimulation seems to play a critical role in salt-induced hypertension and fibrosis, but a lesser role in tissue hypertrophy...
  99. ncbi The in vivo effects of Tulbhagia violacea on blood pressure in a salt-sensitive rat model
    Irene Mackraj
    Pfizer Molecular Biology Research Facility, University of KwaZulu Natal, Durban 4000, South Africa
    J Ethnopharmacol 117:263-9. 2008
    ..The in vivo effects of Tulbhagia violacea on systemic arterial blood pressure and on the renin-angiotensin system in a Dahl salt-sensitive rat model were investigated...
  100. ncbi Congenic strains reveal the effect of the renin gene on skeletal muscle angiogenesis induced by electrical stimulation
    Micheline M de Resende
    Biotechnology and Bioengineering Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 33:33-40. 2008
    ..The present study emphasizes the importance of maintaining normal renin regulation as well as ANG II levels during the angiogenesis process with a combination of physiological, genetic, and pharmacological manipulation of the RAS...
  101. ncbi Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase
    Natalia Makhanova
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 701 Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
    Hypertension 51:134-40. 2008
    ....

Research Grants64

  1. Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular Function
    ANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010
    ..Americans enrolled in the NIH-funded ONOSS study to examine the following before and after a 6 week period of dietary sodium supplementation: Aim #1: determine blood pressure (BP)(cuff and ambulatory 24 hour), arterial stiffness (AS), ..
  2. Endogenous Aldosterone and Glucose Homeostasis
    JAMES MATTHEW LUTHER; Fiscal Year: 2013
    ..We anticipate that targeted RAAS inhibition will minimize the adverse metabolic effects of dietary sodium restriction or diuretic administration, and improve glucose tolerance...
  3. Diet and pathophysiology of heart failure with preserved ejection fraction
    Scott L Hummel; Fiscal Year: 2013
    ..In 'salt-sensitive'animal models, high dietary sodium intake induces oxidative stress and inflammation in the heart, kidneys, and vasculature that cause HFpEF...
  4. Nutrition Intervention to Reduce Symptoms in Patients with Advanced Heart Failure
    Terry A Lennie; Fiscal Year: 2013
    ..Therefore, the purposes of this study are to test the effects of a 6-month nutrition intervention o dietary sodium reduction combined with supplementation of lycopene and omega-3 fatty acids on heart failure symptoms, health-..
  5. Vascular Endothelial Dysfunction in Older Adults: Dietary Sodium Restriction
    Kristen Jablonski; Fiscal Year: 2010
    ..Research Project: This project will determine the efficacy of dietary sodium restriction (DSR) to improve vascular endothelial function, a key expression of vascular aging, as assessed by ..
  6. Beta2-Adrenergic Receptor Gene Variation and Cardiovascular Control in Humans
    John H Eisenach; Fiscal Year: 2012
    ..maneuvers like mental stress and handgrip, [unreadable]2-mediated cardiac and vascular function, and dietary sodium manipulation...
  7. Family-Based Genome-wide Association Study for Salt-Sensitivity of Blood Pressure
    Jiang He; Fiscal Year: 2011
    ..to localize and identify genetic variants which determine an individual's blood pressure (BP) response to dietary sodium intake by conducting a two-stage genome-wide association (GWA) study using the data and DNA specimens ..
  8. Modifying Lifestyle in Prehypertensive Older Rural Women
    CAROL HALL PULLEN; Fiscal Year: 2010
    ..Approaches to Stop Hypertension (DASH) diet that is high in fruits, vegetables and low fat dairy products;dietary sodium reduction;regular endurance physical activity supplemented by resistance exercise;and weight reduction by ..
  9. Multigene Kinase Network, Kidney Transport and Salt in Essential Hypertension
    Paul A Welling; Fiscal Year: 2010
    ..disorder of hypertension and hyperkalemia, to control kidney salt excretion and maintain blood pressure;2) Dietary sodium and potassium differently trigger signaling through the STK39/WNK pathway to regulate the activity of a key ..
  10. Vitamin D Deficiency Augments Renin-Angiotensin System Activity in Obesity
    Anand Vaidya; Fiscal Year: 2011
    ..on the RAS, all subjects will be washed-out of any medications that interfere with the RAS, and maintained in dietary sodium, potassium, and calcium balance...
  11. GRK4 and development of salt sensitivity
    Pedro A Jose; Fiscal Year: 2012
    ..However, dietary sodium restriction may not be beneficial to all...
  12. Experience of Managing ESRD Dietary Modications
    MAYA NICOLE CLARK; Fiscal Year: 2011
    ..Self-management of dietary sodium and fluid restriction are critical to ensuring positive health outcomes for ESRD patients requiring ..
  13. Discovery of Gene Variants and Mechanisms Underlying Salt-Sensitive Hypertension
    Laura A Cox; Fiscal Year: 2013
    ..Major obstacles include difficulty controlling dietary sodium in human studies and availability of large, salt-na[unreadable]ve human populations to identify sodium-..
  14. Sodium Sensitivity and Risk of Hypertension
    Jiang He; Fiscal Year: 2011
    ..In addition, we will repeat the dietary sodium and potassium interventions as well as the cold pressor test in a random sub-sample of GenSalt study ..
  15. Aldosterone-independent regulation of ENaC by systemic salt
    Oleh Pochynyuk; Fiscal Year: 2013
    ..and inhibitory Bradykinin (BK) cascades is necessary for proper adaptation of ENaC activity to variations in dietary sodium. Our preliminary work strongly supports our central hypothesis that Ang II directly stimulates ENaC-mediated ..
  16. Coordination of Renal K and Na Transport by Vesicle Traffic
    James B Wade; Fiscal Year: 2013
    ..to either conserve sodium or excrete potassium, depending on whether aldosterone is induced by a change in dietary sodium or potassium...
  17. Effects of Dietary Sodium and Potassium Intake on Subclinical and Clinical Cardio
    Cheryl Anderson; Fiscal Year: 2012
    ..The objectives of Dr. Anderson's research plan are to examine the main and interactive effects of dietary sodium and potassium intake (measured by 24-hour urinary excretion) on echocardiographic left ventricular (LV) mass ..
  18. Sodium and Cardiovascular Disease in Patients with Chronic Kidney Disease
    Jiang He; Fiscal Year: 2010
    ..The few prospective epidemiologic studies that examined the relationship between dietary sodium and potassium intake and risk of CVD provided contradictory findings...
  19. MINORITY SCHOOL FACULTY DEVELOPMENT AWARD
    HALCYON WATKINS; Fiscal Year: 1992
    ..development of hypertension and urinary sodium excretion in genetic hypertensive rats on different levels of dietary sodium intake...
  20. REVERSAL OF MYOCARDIAL HYPERTROPHY IN HYPERTENSION
    Subha Sen; Fiscal Year: 2002
    ..Influential factors are dietary sodium, catecholamines, and many pharmacological agents used as antihypertensive drugs...
  21. gamma-MSH and Sodium Metabolism
    Michael Humphreys; Fiscal Year: 2007
    Variations in dietary sodium intake initiate integrated adjustments in neural and hormonal systems regulating sodium excretion by the kidneys in order to maintain overall sodium balance...
  22. EFFECT OF SODIUM ON BAROREFLEX FUNCTION IN MAN
    Mark Creager; Fiscal Year: 1991
    ..II and vasopressin will be measured in 45 normotensive and 45 hypertensive subjects during low and high dietary sodium intake...
  23. A Family Partnership Intervention for Heart Failure
    Sandra Dunbar; Fiscal Year: 2009
    ..Patient variables and measures are dietary sodium (24-hour urinary sodium), medication adherence to HF drugs including angiotensin converting enzyme inhibitors ..
  24. SODIUM-POTASSIUM BLOOD PRESSURE TRIAL IN CHILDREN
    Alan Sinaiko; Fiscal Year: 1991
    ..This project will test the hypothesis that a reduction of dietary sodium and/or an increase in the potassium-sodium ratio will decrease the rate of rise in blood pressure during ..
  25. Etiology of Age-Related Defects in Urine Concentration
    Ying Tian; Fiscal Year: 2001
    ..water (dehydration, Aim 1); 2) increased extracellular fluid water (water loading, Aim 2); and 3) altered dietary sodium intake (low, normal, and high NaCl diet, Aim 3)...
  26. 24,25-DIHYDROXYVITAMIN D: MARKER OF SALT SENSITIVITY
    Connie Weaver; Fiscal Year: 2001
    ..The primary aim of this proposal is to test the hypothesis that high dietary sodium increases the calcium intakes required for optimal calcium retention in both black and white adolescent girls...
  27. NEURAL CONTROL OF FLUID HOMEOSTASIS IN HYPERTENSION
    Gregory Fink; Fiscal Year: 2001
    ..This is particularly the case where dietary sodium chloride (salt) intake is high...
  28. HUMORAL MECHANISMS IN CARDIAC HYPERTROPHY
    Shirley Smith; Fiscal Year: 1991
    ..b>Dietary sodium has been shown to affect the concentration of AII and the atrial granules which contain a natriuretic hormone...
  29. NEUROHUMORAL CONTROL OF BLOOD VOLUME
    Thomas Peterson; Fiscal Year: 1992
    ..of the renal nerves and/or increases in ANF for eliciting the renal excretory responses to chronic changes in dietary sodium intake, (4) to determine if the level of sodium intake affects the magnitude of and renal nerve and ANF ..
  30. CHRONIC STRESS & SODIUM EFFECTS ON HYPERTENSION
    JAYLAN TURKKAN; Fiscal Year: 1991
    ..and after six months of exposure to daily behavioral stress sessions combined with daily ingestion of excess dietary sodium. Controls will receive stress only...
  31. STRESS, SODIUM, AND BLOOD PRESSURE REGULATION
    Thomas Pickering; Fiscal Year: 1990
    ..Half of the subjects in each group will be randomized to take slow release sodium capsules to increase their dietary sodium by 100 meq/day, and the other half matching placebo...
  32. RENAL HEMODYNAMIC ABNORMALITIES IN EARLY DIABETES
    NORMAN BANK; Fiscal Year: 1991
    ..Long-term studies will be carried out to determine whether dietary sodium restriction prevents renal pathologic changes of diabetes and proteinuria...
  33. Tissue Kallikrein, Oxidative Stress and Renal Fibrosis
    Julie Chao; Fiscal Year: 2007
    ..salt-induced hypertension and end-stage renal failure, as well as with blood pressure responses to changes in dietary sodium restriction...
  34. ABNORMAL PRESSURE NATRIURESIS IN HYPERTENSION
    Joey Granger; Fiscal Year: 2009
    ..renal medullary endothelin system plays a greater role in regulating sodium excretion and blood pressure as dietary sodium intake is increased 2) To test the hypothesis that the reduction in sodium excretion and elevation in arterial ..
  35. Gene-Environment Interactions and Stroke Susceptibility
    Myriam Fornage; Fiscal Year: 2004
    ..The role of dietary sodium and potassium in modulating the onset of stroke has been well documented both in humans and animal models...
  36. DIETARY SODIUM RESTRICTION IN GENERAL MEDICAL
    Myron Weinberger; Fiscal Year: 1991
    ..b>Dietary sodium restriction has been advocated for the primary or adjunctive treatment of essential hypertension but practical ..
  37. SODIUM, HYPERTENSION, AND RENAL A2-RECEPTORS
    WILLIAM PETTINGER; Fiscal Year: 1992
    b>Dietary sodium intake can have a profound influence on blood pressure of hypertensive patients...
  38. INSULIN ACTION, SODIUM AND EXERCISE IN HYPERTENSION
    Donald Dengel; Fiscal Year: 1999
    ..These metabolic changes may raise BP in the elderly by increasing sensitivity to dietary sodium and causing sodium and water retention to reduce renal plasma flow (RPF) and increase glomerular filtration ..
  39. SODIUM & NEUROPEPTIDES IN STRESS INDUCED HYPERTENSION
    JULIANNA SZILAGYI; Fiscal Year: 1991
    ..three models of stress (territorial stress, rotation stress and isolation stress) while being exposed to three dietary sodium regimes (low, normal, high sodium)...
  40. STRESS, SODIUM, AND BLOOD PRESSURE REGULATION
    GERALD DIBONA; Fiscal Year: 1991
    ..is designed to determine the physiological and pathophysiological factors involved in the interaction between dietary sodium intake and environmental stress in relation to the pathogenesis of hypertension...
  41. DIETARY CONTROL AND PREVENTION OF HYPERTENSION
    RICHARD GILLUM; Fiscal Year: 1980
    ..2. Weight maintenance plus dietary sodium restriction to 70 mEq sodium per day...
  42. PATTERNS OF CARDIOVASCULAR REACTIVITY IN BLACKS
    Norman Anderson; Fiscal Year: 1991
    ..vascular and neuroendocrine reactivity will be examined as a function of resting blood pressure level, dietary sodium intake, and socioeconomic status...
  43. Plasticity of Gustatory Primary Afferent Circuitry
    Olivia May; Fiscal Year: 2004
    ..fields have been identified as regions undergoing considerable plasticity in response to restriction of dietary sodium during development...
  44. VASCULAR EFFECTS OF INHIBITORY BEHAVIORAL ADAPTATIONS
    David Anderson; Fiscal Year: 1980
    ..Dogs will be exposed to (a) stress conditioning in a context of dietary sodium restriction, (b) salt loading without stress conditioning, or (c) stress conditioning plus salt loading over ..
  45. End organ damage in children with primary hypertension
    Deborah Jones; Fiscal Year: 2009
    ..members with hypertension, insulin resistance, low birth weight or intrauterine growth retardation and liberal dietary sodium. Therefore, it seems intuitive that prevention of adult cardiovascular disease should begin during childhood...
  46. ADOLESCENT BLOOD PRESSURE VARIATION AND VENTRICULAR
    CRAIG EWART; Fiscal Year: 1990
    ..if a tendency to hyperkinetic circulation and higher prevailing BP exacerbated by personality, stress, and dietary sodium lead to increase LVH at follow-up...
  47. TRANSTELEPHONIC MONITORING OF HYPERTENSION IN AFRICAN AM
    WILLIAM GENTHE; Fiscal Year: 2000
    ..3) Achievement of appropriate lifestyle changes (weight loss, dietary sodium and fat restriction, increase in exercise, decrease in alcohol intake, and smoking cessation) that will ..
  48. NEUROBEHAVIORAL BASES OF STRESS-INDUCED HYPERTENSION
    James Lawler; Fiscal Year: 1991
    ..A number of hypotheses relating the interactions between dietary sodium intake, tail shock stress, exercise and genetic history of hypertension will be tested in animals - with ..
  49. TREATMENT OF MILD HYPERTENSION STUDY (TOMHS)
    Richard Grimm; Fiscal Year: 1991
    ..group also is advised nonpharmacologic methods to control their blood pressure including weight loss, dietary sodium reduction, alcohol reduction and increased leisure-time physical activity...
  50. CENTRAL CONTROL OF OXYTOCIN RELEASE DURING GESTATION
    STEVEN BEALER; Fiscal Year: 2008
    ..abstract_text> ..
  51. Altered Baroreflex Responses by Dietary Sodium
    STEVEN BEALER; Fiscal Year: 2003
    The along objectives of this research project are to understand the mechanisms through which dietary sodium modifies baroreflex sensitivity...
  52. Beta-2 Receptor Polymorphisms and Vasodilation in Humans
    John Eisenach; Fiscal Year: 2007
    ..My long-term career goal is to become an independent investigator performing physiology and pharmacology studies directed at the genomics of the cardiovascular system in humans. ..
  53. BMI, Nutrition, Inflammation and Heart Failure Outcomes
    Terry Lennie; Fiscal Year: 2007
    ..An understanding of the underlying mechanisms may also allow application of these findings to underweight patients resulting in improved outcomes for these patients. ..
  54. Neurobehavioral Control of Body Fluid Balance in Mouse
    Alan Johnson; Fiscal Year: 2009
    ..heat) challenges. These studies will be especially important for understanding mechanisms underlying pathological conditions such as hypertension and congestive heart failure where excess thirst and sodium intake have been documented. ..
  55. Angiotensin II Mediates Early Changes in Diabetic Kidney
    Helmy Siragy; Fiscal Year: 2007
    ..The proposed studies will help understand the mechanisms that are involved in diabetic the development of new therapeutic modalities to prevent or slowdown the development ..
  56. AT2 Receptor Modulates Renal Angiotensin II Levels
    Helmy Siragy; Fiscal Year: 2005
    ..Data obtained from this proposal will lead to increased understanding of the pathophysiology of hypertension and development of novel therapies for its management. ..
  57. SEX HORMONES AND BODY FLUID REGULATION
    NINA STACHENFELD; Fiscal Year: 2003
    ....