salts

Summary

Summary: Substances produced from the reaction between acids and bases; compounds consisting of a metal (positive) and nonmetal (negative) radical. (Grant & Hackh's Chemical Dictionary, 5th ed)

Top Publications

  1. ncbi Ion pairs and the thermotolerance of proteins from hyperthermophiles: a "traffic rule" for hot roads
    A Karshikoff
    Centre for Structural Biochemistry, Karolinska Institutet, Novum, 14157 Huddinge, Sweden
    Trends Biochem Sci 26:550-6. 2001
  2. ncbi Seasonal flows on warm Martian slopes
    Alfred S McEwen
    Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ 85721, USA
    Science 333:740-3. 2011
  3. doi Transgenic expression of MYB15 confers enhanced sensitivity to abscisic acid and improved drought tolerance in Arabidopsis thaliana
    Zhenhua Ding
    State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    J Genet Genomics 36:17-29. 2009
  4. ncbi Direct interaction of a divergent CaM isoform and the transcription factor, MYB2, enhances salt tolerance in arabidopsis
    Jae Hyuk Yoo
    Division of Applied Life Science BK21 program, Plant Molecular Biology and Biotechnology Research Center, and Environmental Biotechnology National Core Research Center, Gyeongsang National University, Jinju 660 701, Korea
    J Biol Chem 280:3697-706. 2005
  5. pmc SOS2 promotes salt tolerance in part by interacting with the vacuolar H+-ATPase and upregulating its transport activity
    Giorgia Batelli
    Institute for Integrative Genome Biology and Department of Botany and Plant Sciences, University of California, Riverside, California 92521, USA
    Mol Cell Biol 27:7781-90. 2007
  6. ncbi Salt shield: intracellular salts provide cellular protection against ionizing radiation in the halophilic archaeon, Halobacterium salinarum NRC-1
    A Kish
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    Environ Microbiol 11:1066-78. 2009
  7. doi Effects of salts on internal DNA pressure and mechanical properties of phage capsids
    Alex Evilevitch
    Department of Physics, Carnegie Mellon University, PA 15213, USA
    J Mol Biol 405:18-23. 2011
  8. ncbi Three novel, structurally unique spirocyclic alkaloids from the halotolerant B-17 fungal strain of Aspergillus variecolor
    Wen Liang Wang
    Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China
    Chem Biodivers 4:2913-9. 2007
  9. ncbi Important roles of drought- and cold-inducible genes for galactinol synthase in stress tolerance in Arabidopsis thaliana
    Teruaki Taji
    Laboratory of Plant Molecular Biology, RIKEN Tsukuba Institute, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    Plant J 29:417-26. 2002
  10. doi When do water-insoluble polyion-surfactant ion complex salts "redissolve" by added excess surfactant?
    Salomé dos Santos
    Division of Physical Chemistry, Department of Chemistry, Lund University, P O Box 124, SE 22100 Lund, Sweden
    Langmuir 27:592-603. 2011

Detail Information

Publications314 found, 100 shown here

  1. ncbi Ion pairs and the thermotolerance of proteins from hyperthermophiles: a "traffic rule" for hot roads
    A Karshikoff
    Centre for Structural Biochemistry, Karolinska Institutet, Novum, 14157 Huddinge, Sweden
    Trends Biochem Sci 26:550-6. 2001
    ..This feature is less evident in proteins from thermophilic organisms and is absent from mesophile-derived proteins...
  2. ncbi Seasonal flows on warm Martian slopes
    Alfred S McEwen
    Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ 85721, USA
    Science 333:740-3. 2011
    ..Liquid brines near the surface might explain this activity, but the exact mechanism and source of water are not understood...
  3. doi Transgenic expression of MYB15 confers enhanced sensitivity to abscisic acid and improved drought tolerance in Arabidopsis thaliana
    Zhenhua Ding
    State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    J Genet Genomics 36:17-29. 2009
    ....
  4. ncbi Direct interaction of a divergent CaM isoform and the transcription factor, MYB2, enhances salt tolerance in arabidopsis
    Jae Hyuk Yoo
    Division of Applied Life Science BK21 program, Plant Molecular Biology and Biotechnology Research Center, and Environmental Biotechnology National Core Research Center, Gyeongsang National University, Jinju 660 701, Korea
    J Biol Chem 280:3697-706. 2005
    ..Therefore, we suggest that a specific CaM isoform mediates salt-induced Ca2+ signaling through the activation of an MYB transcriptional activator, thereby resulting in salt tolerance in plants...
  5. pmc SOS2 promotes salt tolerance in part by interacting with the vacuolar H+-ATPase and upregulating its transport activity
    Giorgia Batelli
    Institute for Integrative Genome Biology and Department of Botany and Plant Sciences, University of California, Riverside, California 92521, USA
    Mol Cell Biol 27:7781-90. 2007
    ..Our results suggest that regulation of V-ATPase activity is an additional key function of SOS2 in coordinating changes in ion transport during salt stress and in promoting salt tolerance...
  6. ncbi Salt shield: intracellular salts provide cellular protection against ionizing radiation in the halophilic archaeon, Halobacterium salinarum NRC-1
    A Kish
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    Environ Microbiol 11:1066-78. 2009
    ..The finding that not only Mn/Fe but also the presence of halides can decrease the oxidative damage to DNA and proteins emphasizes the significance of the intracellular milieu in determining microbial radiation resistance...
  7. doi Effects of salts on internal DNA pressure and mechanical properties of phage capsids
    Alex Evilevitch
    Department of Physics, Carnegie Mellon University, PA 15213, USA
    J Mol Biol 405:18-23. 2011
    ..The model also predicts the stiffness of other DNA-filled capsids, which we confirm using bacteriophage ϕ29 and herpes simplex virus type 1 particles...
  8. ncbi Three novel, structurally unique spirocyclic alkaloids from the halotolerant B-17 fungal strain of Aspergillus variecolor
    Wen Liang Wang
    Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China
    Chem Biodivers 4:2913-9. 2007
    ..All compounds were shown to exhibit weak cytotoxic and antioxidant activities...
  9. ncbi Important roles of drought- and cold-inducible genes for galactinol synthase in stress tolerance in Arabidopsis thaliana
    Teruaki Taji
    Laboratory of Plant Molecular Biology, RIKEN Tsukuba Institute, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    Plant J 29:417-26. 2002
    ....
  10. doi When do water-insoluble polyion-surfactant ion complex salts "redissolve" by added excess surfactant?
    Salomé dos Santos
    Division of Physical Chemistry, Department of Chemistry, Lund University, P O Box 124, SE 22100 Lund, Sweden
    Langmuir 27:592-603. 2011
    ..A number of stoichiometric polyion-surfactant ion "complex salts" were synthesized and they consisted of akyltrimethylammonium surfactant ions of two different alkyl chain lengths ..
  11. ncbi Contribution of surface salt bridges to protein stability
    P Strop
    Biochemistry Option, California Institute of Technology, Pasadena, California 91125, USA
    Biochemistry 39:1251-5. 2000
    ..5 kcal mol(-)(1). The entropic cost of making a surface salt bridge involving the protein's backbone is reduced, since the backbone has already been immobilized upon protein folding...
  12. ncbi Bartter syndromes and other salt-losing tubulopathies
    Robert Kleta
    Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Nephron Physiol 104:p73-80. 2006
    ..We summarize recent findings in the field in the context of human diseases and a pathophysiologic basis for their treatment...
  13. ncbi Dominant role of prostaglandin E2 EP4 receptor in furosemide-induced salt-losing tubulopathy: a model for hyperprostaglandin E syndrome/antenatal Bartter syndrome
    Rolf M Nusing
    Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt 60590, Germany
    J Am Soc Nephrol 16:2354-62. 2005
    ..In summary, these findings demonstrate that the EP4 receptor mediates PGE2-induced renin secretion and that EP1, EP3, and EP4 receptors all contribute to enhanced PGE2-mediated salt and water excretion in the HPS/aBS model...
  14. ncbi Electrostatic and hydrophobic interactions play a major role in the stability and refolding of halophilic proteins
    Tsutomu Arakawa
    Alliance Protein Laboratories, 3957 Corte Cancion, Thousand Oaks, CA 91360, USA
    Protein Pept Lett 11:125-32. 2004
    In general, halophilic proteins are stable only in the presence of salts at high concentrations...
  15. doi Salt bridges in the hyperthermophilic protein Ssh10b are resilient to temperature increases
    Meng Ge
    Key Laboratory of Bioinformatics, Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    J Biol Chem 283:31690-6. 2008
    ..Implications of this finding are useful for engineering proteins with enhanced thermostability...
  16. pmc Generation of oxidant response to copper and iron nanoparticles and salts: Stimulation by ascorbate
    Robert H Rice
    Department of Environmental Toxicology, University of California, Davis, CA 95616, USA
    Chem Biol Interact 181:359-65. 2009
    ..Soluble salts of copper and iron exhibited the same contrast in activities as the respective combustion-generated particles...
  17. pmc Role of the WNK-activated SPAK kinase in regulating blood pressure
    Fatema H Rafiqi
    University of Dundee, Scotland, UK
    EMBO Mol Med 2:63-75. 2010
    ..See accompanying Closeup by Maria Castañeda-Bueno and Gerald Gamba (DOI 10.1002/emmm.200900059)...
  18. doi Drug salts and solubilization: modeling the influence of cyclodextrins on oral absorption
    Ece Dilber Gamsiz
    Department of Chemical Engineering, Northeastern University, 342 Snell Engineering Center, Boston, MA 02115, USA
    Ann Biomed Eng 39:455-68. 2011
    ..Modeling enabled examination of which physical and chemical properties result in oral absorption enhancement or decrement for drug salt administered as a physical mixture with CD...
  19. ncbi Sensitive electrospray mass spectrometry analysis of one-bead-one-compound peptide libraries labeled by quaternary ammonium salts
    Remigiusz Bąchor
    University of Wrocław, ul F Joliot Curie 14, 50 383 Wrocław, Poland
    Mol Divers 16:613-8. 2012
    ..The application of an efficient method of peptide derivatization by quaternary ammonium salts (QAS) formation increases ionization efficiency and reduces the detection limit, allowing analysis of trace ..
  20. ncbi Structure--activity relationship and preclinical evaluation of carbon-11-labeled ammonium salts as PET--myocardial perfusion imaging agents
    Ohad Ilovich
    Cyclotron Radiochemistry Unit Nuclear Medicine Department, Hadassah Hebrew University Hospital, Jerusalem, 91120, Israel
    Mol Imaging Biol 14:625-36. 2012
    ..Due to the limited availability of suitable positron emission tomography (PET) tracers, the majority of myocardial perfusion imaging (MPI) scans is performed using SPECT rather than PET...
  21. doi Quaternary ammonium salts and their antimicrobial potential: targets or nonspecific interactions?
    Maximilian Tischer
    Institute of Pharmacy and Food Chemistry, University of Wurzburg, Wurzburg, Germany
    ChemMedChem 7:22-31. 2012
    ..This review discusses the structure-activity relationships and the modes of action of the various series of (bis)quaternary ammonium compounds...
  22. ncbi Role of dissolved salts in thermophoresis of DNA: lattice-Boltzmann-based simulations
    Audrey Hammack
    Department of Chemistry, University of Texas at Tyler, Tyler, Texas, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 83:031915. 2011
    ..Brownian dynamics simulation to investigate the dependence of DNA thermophoresis on its interaction with dissolved salts. We find the thermal diffusion coefficient D{T} depends on the molecule size, in contrast with previous ..
  23. doi Physicochemical characterization of creatine N-methylguanidinium salts
    Brandon T Gufford
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska, USA
    J Diet Suppl 7:240-52. 2010
    ..As a zwitterionic compound, creatine can form salts at the N-methyl guanidinium or carboxylic acid functional groups...
  24. ncbi Sensory attributes of complex tasting divalent salts are mediated by TRPM5 and TRPV1 channels
    Celine E Riera
    Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne, Switzerland
    J Neurosci 29:2654-62. 2009
    Complex tasting divalent salts (CTDS) are present in our daily diet, contributing to multiple poorly understood taste sensations...
  25. ncbi Preparation of macroporous biodegradable PLGA scaffolds for cell attachment with the use of mixed salts as porogen additives
    Hong Ru Lin
    Department of Applied Chemistry, Chia Nan University of Pharmacy and Science, Tainan, Taiwan 717
    J Biomed Mater Res 63:271-9. 2002
    ..In addition, the polymer/salts/solvent mixture can be easily handled and molded into scaffolds of any specific shape-for example, thin sheet, ..
  26. pmc Structural basis for the enhanced thermal stability of alcohol dehydrogenase mutants from the mesophilic bacterium Clostridium beijerinckii: contribution of salt bridging
    Oren Bogin
    Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    Protein Sci 11:2561-74. 2002
    ....
  27. ncbi Modification of anomalous swelling in multilamellar vesicles induced by alkali halide salts
    S S Korreman
    Department of Mathematics and Physics (IMFUFA, Roskilde University, Denmark
    Eur Biophys J 30:121-8. 2001
    By use of small-angle X-ray scattering it is shown that addition of alkali halide salts in small amounts (0-200 mM) shifts the repeat spacing in multilamellar DC13PC vesicles and alters the anomalous swelling behaviour close to the main ..
  28. doi Eliminating inhibition of enzymatic hydrolysis by lignosulfonate in unwashed sulfite-pretreated aspen using metal salts
    Hao Liu
    State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China
    Bioresour Technol 101:9120-7. 2010
    ..These results demonstrate that applying divalent metal salts eliminates the need for washing, thereby saving considerable process water and cost for production of chemicals ..
  29. ncbi Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity
    Timothy A Hill
    Advanced Synthetic Materials Group, Chemistry Building, School Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia
    Bioorg Med Chem Lett 14:3275-8. 2004
    ..However, introduction of a hydrophobic collar proximal to the charged site was beneficial to dynamin GTPase inhibitory action. The most potent compound was myristoyl trimethyl ammonium bromide (MTMAB, IC(50) 3.15 microM)...
  30. ncbi Fiberoptic infrared spectroscopy: a novel tool for the analysis of urine and urinary salts in situ and in real time
    Shmuel Cytron
    Department of Urology, Barzilai Medical Center, Ashkelon, Israel
    Urology 61:231-5. 2003
    To use infrared fiberoptic spectroscopy for the analysis of urinary salts in real time and with no sample processing; and to assess the practical role of this method for the quantitative measurement of the composition of urine and for ..
  31. doi Media composition: salts and osmolality
    Jay M Baltz
    Department of Obstetrics and Gynecology, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada
    Methods Mol Biol 912:61-80. 2012
    The main components of embryo culture media are salts, which dissociate into their component inorganic ions in aqueous solution...
  32. doi Catalytic conversion of dihydroxyacetone to lactic acid using metal salts in water
    Carolus B Rasrendra
    Chemical Engineering Department, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    ChemSusChem 4:768-77. 2011
    We herein present a study on the application of homogeneous catalysts in the form of metal salts on the conversion of trioses, such as dihydroxyacetone (DHA), and glyceraldehyde (GLY) to lactic acid (LA) in water...
  33. ncbi Field amplified injection in the presence of salts for capillary electrophoresis
    Z K Shihabi
    Pathology Department, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157, USA
    J Chromatogr A 853:3-9. 1999
    b>Salts in the sample are detrimental to the stacking by the field-amplified injection. However, physiological samples often contain salts at levels of about 1% which can diminish the peak height or cause band spreading instead of stacking...
  34. ncbi Some magnesium salts and a mixture of magnesium and calcium salts accelerate skin barrier recovery
    M Denda
    Shiseido Research Center 2, 2 12 1 Fukuura, Kanazwa ku, Yokohama, 236 8643, Japan
    Arch Dermatol Res 291:560-3. 1999
    The effects of four different magnesium salts on the cutaneous barrier recovery rate after barrier disruption were evaluated...
  35. doi Unexpected reactivity of Au25(SCH2CH2Ph)18 nanoclusters with salts
    Manzhou Zhu
    Department of Chemistry, Anhui University, Hefei, Anhui 230026, PR China
    Nanoscale 3:1703-7. 2011
    ..of the chemical reactivity of thiolate-protected [Au(25)(SCH(2)CH(2)Ph)(18)](0) nanoclusters with two types of salts, including tetraoctylammonium halide (TOAX) and NaX...
  36. doi Salt tolerance in soybean
    Tsui Hung Phang
    Department of Biology, Chinese University of Hong Kong, Shatin, Hong Kong, China
    J Integr Plant Biol 50:1196-212. 2008
    ..In this review, we tried to integrate the relevant works on soybean and proposes a working model to describe its salt stress responses at the molecular level...
  37. ncbi Synthesis and structure of selected quaternary N-(1,4-anhydro-5-deoxy-2,3-O-isopropylidene-D,L-ribitol-5-yl)ammonium salts
    Eugenia Skorupa
    Department of Chemistry, University of Gdansk, Sobieskiego 18, PL 80 952 Gdansk, Poland
    Carbohydr Res 339:2355-62. 2004
    ..syntheses have been developed for quaternary N-(1,4-anhydro-5-deoxy-2,3-O-isopropylidene-D,L-ribitol-5-yl)ammonium salts derived from five aromatic amines, pyridine, 2-methylpyridine, 3-carbamoylpyridine, 4-(N,N-dimethylamino)pyridine, ..
  38. ncbi Effect of deicing salts on urban soils and health status of roadside trees in the Opole region
    Izabela Czerniawska-Kusza
    Department of Land Protection, University of Opole, Oleska 22, 45 052 Opole, Poland
    Environ Toxicol 19:296-301. 2004
    This article reports on a study whose aim was to evaluate the impact of snow removal salts on urban soil properties and the health of roadside trees...
  39. ncbi Malsegregation as a possible mechanism of aneuploidy induction by metal salts in MRC-5 human cells
    A I Seoane
    Centro de Investigaciones en Genética Básica y Aplicada, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina
    Environ Mol Mutagen 40:200-6. 2002
    ..The aim of the present study was to provide evidence that the aneugenic effect of some metal salts is the consequence of malsegregation at anaphase and that it is not caused by nondisjunction mechanisms...
  40. ncbi The correlation of RNase A enzymatic activity with the changes in the distance between Nepsilon2-His12 and N delta1-His119 upon addition of stabilizing and destabilizing salts
    A A Moosavi-Movahedi
    Institute of Biochemistry and Biophysics, University of Tehran, Iran
    Protein J 25:117-25. 2006
    The effect of stabilizing and destabilizing salts on the catalytic behavior of ribonuclease A (RNase A) was investigated at pH 7.5 and 25 degrees C, using spectrophotometric, viscometric and molecular dynamic methods...
  41. ncbi Effect of salts on the stability and folding of staphylococcal nuclease
    C Nishimura
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    Biochemistry 40:2113-28. 2001
    ..nuclease (SNase) at neutral pH are significantly perturbed by the presence of moderate to high concentrations of salts. Very substantial increases in stability toward thermal and urea denaturation were observed; for example, 0...
  42. doi MALDI imaging mass spectrometry of lipids by adding lithium salts to the matrix solution
    Christopher D Cerruti
    Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, Gif sur Yvette, France
    Anal Bioanal Chem 401:75-87. 2011
    ..A new sample preparation method is proposed, involving the use of lithium salts in the matrix solution in order to simplify the mass spectra with only lithium-cationized molecules instead of a ..
  43. ncbi Analytical microscopy observations of rat enterocytes after oral administration of soluble salts of lanthanides, actinides and elements of group III-A of the periodic chart
    C Floren
    Service de Gastro Enterologie, Hĵpital St Antoine, Paris, France
    Cell Mol Biol (Noisy-le-grand) 47:419-25. 2001
    ..barrier of nine elements (three of the group III-A, four lanthanides and two actinides), absorbed as soluble salts, has been studied by two microanalytical methods: electron probe X-ray micro analysis (EPMA) and secondary ion ..
  44. doi Exploration of potential prodrug approach of the bis-thiazolium salts T3 and T4 for orally delivered antimalarials
    Sergio A Caldarelli
    Institut des Biomolecules Max Mousseron, UMR CNRS, Universite Montpellier, France
    Bioorg Med Chem Lett 20:3953-6. 2010
    ..and biological evaluation of a series of 37 compounds as precursors of potent antimalarial bis-thiazolium salts (T3 and T4)...
  45. doi Study of ion-paired iridium complexes (soft salts) and their application in organic light emitting diodes
    Chao Wu
    Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, California 90089, USA
    J Am Chem Soc 132:3133-9. 2010
    Three Ir-based materials were synthesized through metathesis reaction between halide and alkali metal salts of two cationic and three anionic Ir complexes, respectively...
  46. ncbi Uptake of atmospheric mercury by deionized water and aqueous solutions of inorganic salts at acidic, neutral and alkaline pH
    D T Waite
    Environment Canada, Regina, SK
    Chemosphere 49:341-51. 2002
    ..The low pH solutions of various salt concentrations and the high pH solutions of high salt concentrations tested in this study generally showed a greater tendency to absorb and retain atmospheric Hg0 than those at a pH closer to neutral...
  47. doi Synthesis and antimicrobial activity of some pyridinium salts
    Vildan Alptüzün
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, 35100, Bornova, Izmir, Turkey
    Molecules 14:5203-15. 2009
    ....
  48. ncbi Effects of high concentration of salts on the esterase activity and structure of a kiwifruit peptidase, actinidain
    Koichi Morimoto
    Department of Biotechnological Science, Kinki University, Nishimitani, Kinokawa, Wakayama 649 6493
    J Biochem 139:1065-71. 2006
    Effects of salts on the activity and stability of actinidain were examined. With increasing salt concentration up to 0...
  49. pmc Halophilic enzyme activation induced by salts
    Gabriel Ortega
    Structural Biology Unit, CIC bioGUNE, Bizkaia Technology Park, Building 800, 48160 Derio, Spain
    Sci Rep 1:6. 2011
    ..This model has been successfully applied to reengineer Hv LigN into an enzyme that is catalytically active in the presence of NaCl...
  50. doi Nanomechanical recognition of N-methylammonium salts
    Marco Dionisio
    Department of Organic and Industrial Chemistry, University of Parma, and INSTM, UdR Parma, Parco Area delle Scienze 17A, 43124 Parma, Italy
    J Am Chem Soc 134:2392-8. 2012
    ..we demonstrate how the energy of the molecular recognition between a supramolecular host and small alkylammonium salts can be harnessed to perform a nanomechanical task in a univocal way...
  51. doi The influence of condition on permeation of Ca(II) ions from solutions of selected calcium's salts through model membrane
    Barbara Dolińska
    Biochefa Pharmaceutical Research and Production Plant, Kasztanowa 3, Sosnowiec, Poland
    Biol Trace Elem Res 140:95-102. 2011
    ..Process was traced depending on the concentration of the appropriate calcium's salts (1, 2.5, and 5 mmol/l) and pH value of acceptor environment (1.3, 6.2, and 7...
  52. ncbi Effect of salts addition on hydrogen production by C. acetobutylicum
    H Alshiyab
    School of Bioscience and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia
    Pak J Biol Sci 11:2193-200. 2008
    The objective of this study is to investigate the effect of salts addition to fermentation medium on hydrogen production, under anaerobic batch culture system...
  53. pmc Fast and high-yield microreactor syntheses of ortho-substituted [(18)F]fluoroarenes from reactions of [(18)F]fluoride ion with diaryliodonium salts
    Joong Hyun Chun
    PET Radiopharmaceutical Sciences Section, Molecular Imaging Branch, National Institute of Mental Health, Rm B3 C346A, Building 10, 10 Center Drive, Bethesda, Maryland 20892 1003, USA
    J Org Chem 75:3332-8. 2010
    ..7 min) with diaryliodonium salts. The microreactor provided a very convenient means for running sequential reactions rapidly with small amounts of ..
  54. pmc Improved matrix-assisted laser desorption/ionization mass spectrometric detection of glycosaminoglycan disaccharides as cesium salts
    Tatiana N Laremore
    Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Rapid Commun Mass Spectrom 21:1315-20. 2007
    ..The lithium, sodium, potassium, rubidium, and cesium salts of SOS were analyzed by UV-MALDI-time-of-flight (TOF)MS using an ionic liquid matrix, bis-1,1,3,3-..
  55. ncbi Effects of salts on protein-surface interactions: applications for column chromatography
    Kouhei Tsumoto
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwanoha, Kashiwa 277 8562, Japan
    J Pharm Sci 96:1677-90. 2007
    ..Most column chromatographies require salts, whether inorganic or organic, for binding, elution or simply better recovery and resolution...
  56. ncbi The polyamine spermine protects against high salt stress in Arabidopsis thaliana
    Koji Yamaguchi
    Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi 980 8577, Japan
    FEBS Lett 580:6783-8. 2006
    ..The data suggest that the absence of spermine causes an imbalance in Ca(2+) homeostasis in the mutant plant. Based on the data obtained, we propose a model for a role of spermine in high salt stress responses...
  57. ncbi Chitosans as nasal absorption enhancers of peptides: comparison between free amine chitosans and soluble salts
    P Tengamnuay
    Department of Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    Int J Pharm 197:53-67. 2000
    A total of three free amine chitosans (CS J, CS L and CS H) and two soluble chitosan salts (CS G and CS HCl) were evaluated for their efficacy and safety as nasal absorption enhancers of peptides based on in situ nasal perfusion and ..
  58. ncbi Effects of engineered salt bridges on the stability of subtilisin BPN'
    C R Erwin
    Corporate Research Division, Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, OH 45239 8707
    Protein Eng 4:87-97. 1990
    ....
  59. ncbi An equilibrium thermodynamic model of the sequestration of calcium phosphate by casein micelles and its application to the calculation of the partition of salts in milk
    Carl Holt
    Hannah Research Institute, KA6 5HL Ayr, UK
    Eur Biophys J 33:421-34. 2004
    ..From this model, a method of calculating the partition of milk salts into diffusible and non-diffusible fractions is obtained...
  60. ncbi Transition metal salts-catalyzed aza-Michael reactions of enones with carbamates
    Shu Kobayashi
    Graduate School of Pharmaceutical Science, The University of Tokyo and CREST, Japan Science and Technology Corporation JST, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Org Lett 4:1319-22. 2002
    Several transition metal salts were found to catalyze aza-Michael reactions of enones with carbamates efficiently. The catalytic activity was strongly dependent on the nature of the metal salts...
  61. doi Systematic study of hydration patterns of phosphoric(V) acid and its mono-, di-, and tripotassium salts in aqueous solution
    Maciej Smiechowski
    Department of Physical Chemistry, Chemical Faculty, Gdansk University of Technology, Narutowicza 11 12, 80 233 Gdansk, Poland
    J Phys Chem B 113:7650-61. 2009
    ..Further interpretation of the energetic and structural properties of hydrating water is enabled by calculating intermolecular interaction energy of water and probability distributions for interatomic oxygen-oxygen distance...
  62. ncbi Relationship between apatite-forming ability and mechanical properties of bioactive PMMA-based bone cement modified with calcium salts and alkoxysilane
    Atsushi Sugino
    Graduate School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    J Mater Sci Mater Med 19:1399-405. 2008
    ..revealed that modification using gamma-methacryloxypropyltrimethoxysilane (MPS) and water-soluble calcium salts such as calcium acetate and calcium hydroxide was effective for providing the PMMA-based bone cement with apatite-..
  63. ncbi Correlation between thermal aggregation and stability of lysozyme with salts described by molar surface tension increment: an exceptional propensity of ammonium salts as aggregation suppressor
    Atsushi Hirano
    Institute of Applied Physics, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki, 305 8573, Japan
    Protein J 26:423-33. 2007
    ..This paper investigates the process of thermal aggregation of lysozyme in the presence of various types of salts. The simple law was found; the aggregation rate of lysozyme increased with increasing melting temperature of the ..
  64. ncbi Atypical effect of salts on the thermodynamic stability of human prion protein
    Adrian C Apetri
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 278:22187-92. 2003
    ..Previous studies indicate that salts promote conformational conversion of the recombinant prion protein into a PrPSc-like form...
  65. ncbi Thermostable variants constructed via the structure-guided consensus method also show increased stability in salts solutions and homogeneous aqueous-organic media
    E Vazquez-Figueroa
    School of Chemical and Biomolecular Engineering, Parker H Petit Institute for Bioengineering and Bioscience, Atlanta, GA 30332 0363, USA
    Protein Eng Des Sel 21:673-80. 2008
    ..method also showed improved stability in solutions with high concentrations of kosmotropic and chaotropic salts and water-miscible organic solvents...
  66. ncbi Electrophysiological responses to salts from antennal chaetoid taste sensilla of the ground beetle Pterostichus aethiops
    Enno Merivee
    Estonian Agricultural University, Institute of Plant Protection, 64 Kreutzwaldi Street, 51014 Tartu, Estonia
    J Insect Physiol 50:1001-13. 2004
    ..1797) (Coleoptera, Carabidae) respond to salts, the three sensory cells, A-, B- and C-cells, producing action potentials that are distinguished by differences in ..
  67. pmc Toward the physical basis of thermophilic proteins: linking of enriched polar interactions and reduced heat capacity of unfolding
    Huan Xiang Zhou
    Institute of Molecular Biophysics and Department of Physics, Florida State University, Tallahassee, FL 32306, USA
    Biophys J 83:3126-33. 2002
    ..A reduced DeltaC(p) might serve as an indicator for the contribution of polar interactions to folding stability...
  68. doi Chitosan and its salts for mucosal and transmucosal delivery
    Maria Cristina Bonferoni
    University of Pavia, Department of Pharmaceutical Chemistry, Pavia, Italy
    Expert Opin Drug Deliv 6:923-39. 2009
    This review considers the application of chitosan and its salts in the delivery of drugs intended to act locally towards diseases of the mucosa itself (mucosal delivery), and to undergo systemic absorption by means of transmucosal routes ..
  69. doi Mesomorphic imidazolium salts: new vectors for efficient siRNA transfection
    William Dobbs
    Institut de Physique et Chimie des Materiaux de Strasbourg, UMR 7504, CNRS Universite de Strasbourg, BP 43, 23 rue du Loess, F 67034 Strasbourg Cedex 2, France
    J Am Chem Soc 131:13338-46. 2009
    ..The two series of salts possess a rich thermotropic mesomorphism, chain-length dependent...
  70. pmc Thermotoga maritima ribonuclease III. Characterization of thermostable biochemical behavior and analysis of conserved base pairs that function as reactivity epitopes for the Thermotoga 23S rRNA precursor
    Lilian Nathania
    Department of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, USA
    Biochemistry 49:7164-78. 2010
    ..These results indicate the conservation, across a broad phylogenetic distance, of positive and negative determinants of reactivity of bacterial RNase III substrates...
  71. doi Antimicrobial activities and cellular responses to natural silicate clays and derivatives modified by cationic alkylamine salts
    Shan Hui Hsu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei 10617 Taiwan, Republic of China
    ACS Appl Mater Interfaces 1:2556-64. 2009
    ..The derivatives of NSP (NSP-S) which were modified by C18-fatty amine salts via ionic exchange association exhibited the highest antibacterial activity in the aqueous state among all clays...
  72. ncbi Conformation and stability of alpha-helical membrane proteins. 2. Influence of pH and salts on stability and unfolding of rhodopsin
    Reiner Vogel
    Biophysics Group, Institut für Molekulare Medizin und Zellforschung, Albert Ludwigs Universitat Freiburg, Hermann Herder Strasse 9, D 79104 Freiburg, Germany
    Biochemistry 41:3536-45. 2002
    ..We further characterized the influence of salts on the stability of the rhodopsin helix bundle, which was found to follow the Hofmeister series...
  73. doi Haloarchaeal diversity in 23, 121 and 419 MYA salts
    J S Park
    Canadian Institute for Advanced Research, Program in Integrated Microbial Diversity, and Department of Biology, Dalhousie University, Halifax, Canada
    Geobiology 7:515-23. 2009
    ..The DNA demonstrates that unknown haloarchaea and the Halobacterium were key components in ancient hypersaline environments. Halorubrum and Haloarcula appear to be a dominant group in relatively modern hypersaline habitats...
  74. ncbi Contribution of surface salt bridges to protein stability: guidelines for protein engineering
    George I Makhatadze
    Department of Biochemistry and Molecular Biology, College of Medicine, Penn State University, 500 UniversityDrive, Hershey, PA 17033 2390, USA
    J Mol Biol 327:1135-48. 2003
    ..Implications of these findings for engineering proteins with enhanced thermostability are discussed...
  75. pmc Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils
    Aneta T Petkova
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0520, USA
    Biochemistry 45:498-512. 2006
    ..These models apply to Abeta(1-40) fibrils grown with gentle agitation. We also present evidence for different internal quaternary contacts in Abeta(1-40) fibrils grown without agitation, which are morphologically distinct...
  76. pmc Global transcriptional, physiological, and metabolite analyses of the responses of Desulfovibrio vulgaris hildenborough to salt adaptation
    Zhili He
    Institute for Environmental Genomics and Department of Botany and Microbiology, University of Oklahoma, Norman, Oklahoma 73019, USA
    Appl Environ Microbiol 76:1574-86. 2010
    ..A conceptual model that links the observed results to currently available knowledge is proposed to increase our understanding of the mechanisms of D. vulgaris adaptation to elevated NaCl levels...
  77. pmc A rigidifying salt-bridge favors the activity of thermophilic enzyme at high temperatures at the expense of low-temperature activity
    Sonia Y Lam
    School of Life Sciences, Centre for Protein Science and Crystallography, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    PLoS Biol 9:e1001027. 2011
    ..Here we employed a thermophilic acylphosphatase from Pyrococcus horikoshii and its homologous mesophilic acylphosphatase from human as a model to study how local rigidity of an active-site residue affects the enzymatic activity...
  78. pmc Diffusion, exclusion, and specific binding in a large channel: a study of OmpF selectivity inversion
    Antonio Alcaraz
    Departamento de Fisica, Universitat Jaume I, 12080 Castellon, Spain
    Biophys J 96:56-66. 2009
    ..Second, the higher anionic (versus cationic) transport rate expected for bulk solutions of chloride salts of divalent cations is the leading cause of the measured anionic selectivity of the channel...
  79. ncbi Effect of salts on the structural behavior of hPrP alpha2-helix-derived analogues: the counterion perspective
    Luisa Ronga
    Dipartimento delle Scienze Biologiche, C I R Pe B, Università Federico II di Napoli and Istituto di Bioimmagini e Biostrutture, CNR, Via Mezzocannone 16, 80134 Napoli, Italy
    J Pept Sci 12:790-5. 2006
    ..Employment of various sodium salts allowed us to highlight the fact that chaotropic anions favor unstructured conformation, whereas kosmotropic ..
  80. ncbi Polyaniline nanofiber composites with metal salts: chemical sensors for hydrogen sulfide
    Shabnam Virji
    Materials Processing and Evaluation Department, Space Materials Laboratory, The Aerospace Corporation, P O Box 92957 M2 248, Los Angeles, CA 90009, USA
    Small 1:624-7. 2005
  81. pmc Resurrecting abandoned proteins with pure water: CD and NMR studies of protein fragments solubilized in salt-free water
    Minfen Li
    Department of Biological Sciences, Faculty of Science, Yong Loo Lin School of Mediciine, National Univeristy of Singapore, Singapore
    Biophys J 91:4201-9. 2006
    ..Our discovery not only gives a novel insight into the properties of insoluble proteins, but also sheds the first light that we know of on previously unknown regimes associated with proteins...
  82. ncbi Temperature and amiloride alter taste nerve responses to Na+, K+, and NH+4 salts in rats
    R F Lundy
    Department of Psychology, Florida State University, Tallahassee 32306 1051, USA
    Brain Res 744:309-17. 1997
    ..Taste nerve responses to all Na+ and NH4+ salts, but not K/ salts, were significantly smaller at 25 degrees C than at 35 degrees C...
  83. pmc Changes in phosphatidylcholine headgroup tilt and water order induced by monovalent salts: molecular dynamics simulations
    Jonathan N Sachs
    Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biophys J 86:3772-82. 2004
    The association between monovalent salts and neutral lipid bilayers is known to influence global bilayer structural properties such as headgroup conformational fluctuations and the dipole potential...
  84. ncbi Influence of salts and phenolic compounds on olive mill wastewater detoxification using superabsorbent polymers
    L C Davies
    Centre of Biological and Chemical Engineering, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisbon, Portugal
    Bioresour Technol 95:259-68. 2004
    ..the absorption capacity was evaluated for the principal absorption-inhibition constituent of OMW, mineral salts and for phytotoxic-components, the phenolic compounds...
  85. ncbi The Nha1 antiporter of Saccharomyces cerevisiae mediates sodium and potassium efflux
    M A Bañuelos
    Laboratoire de Microbiologie et de Genetique, Université Louis Pasteur CNRS, Strasbourg, France
    Microbiology 144:2749-58. 1998
    ..Both systems have a complementary action to maintain the intracellular steady-state concentration of K+ and Na+...
  86. ncbi DNA-mediated phase behavior of microsphere suspensions
    Paul L Biancaniello
    Department of Physics and Astronomy, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Langmuir 23:2688-93. 2007
    ..Computational analysis assigns a 4 kBT attraction between pairs of complementary microspheres at the destabilizing fluid --> fluid + aggregates transition...
  87. ncbi Morphology of actin assemblies in response to polycation and salts
    Hyuck Joon Kwon
    Graduate School of Science, Hokkaido University, Sapporo 060 0810, Japan, and SORST, JST, Sapporo, 060 0810, Japan
    Biomacromolecules 6:3005-9. 2005
    ..Our results indicate that the semiflexible polyelectrolyte nature of F-actins is important for controlling the morphology and growth of actin architectures in cells...
  88. ncbi Transport of antimony salts by Arabidopsis thaliana protoplasts over-expressing the human multidrug resistance-associated protein 1 (MRP1/ABCC1)
    Landry Gayet
    CEA Cadarache, DSV DEVM LEMS, UMR 6191 CNRS CEA Université Aix Marseille II, 13108 St Paul lez Durance, France
    FEBS Lett 580:6891-7. 2006
    ..In these plants, expression of MRP1 did not increase plant resistance to antimony salts (Sb(III)), a classical glutathione-conjugate substrate of MRP1...
  89. ncbi Fermentation of 12% (w/v) glucose to 1.2 M lactate by Escherichia coli strain SZ194 using mineral salts medium
    S Zhou
    Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA
    Biotechnol Lett 28:663-70. 2006
    ..B, strain SZ194, was developed that produces over 1 M D-lactate from glucose (or sucrose) in 72 h using mineral salts medium supplemented with 1 mM: betaine in simple anaerobic fermentations. Rates and yields were highest at pH 7.5...
  90. pmc A DEAD-box protein alone promotes group II intron splicing and reverse splicing by acting as an RNA chaperone
    Sabine Mohr
    Institute for Cellular and Molecular Biology, Department of Chemistry and Biochemistry and Section of Molecular Genetics and Microbiology, School of Biological Sciences, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 103:3569-74. 2006
    ..More generally, our results provide additional evidence for the widespread role of RNA chaperones in folding cellular RNAs...
  91. ncbi Occupational hypersensitivity to metal salts, including platinum, in the secondary industry
    A Cristaudo
    Servizio di Allergologia, Istituto San Gallicano, IRCCS, Rome, Italy
    Allergy 60:159-64. 2005
    ..Our aim was to determine the prevalence and the clinical characteristics of hypersensitivity to platinum salts and to other elements of the platinum group.
  92. ncbi Composite formation from hydroxyapatite with sodium and potassium salts of polyphosphazene
    Y E Greish
    Intercollege Materials Research Laboratory, The Pennsylvania State University, University Park, PA 16802, USA
    J Mater Sci Mater Med 16:613-20. 2005
    ..In the presence of 1% by weight of polyphosphazenes, composites comprised of SHAp and calcium cross-linked polymer salts were formed. Thus a mechanism for binding between polymer chains was established...
  93. pmc Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels
    Kimberley B Craven
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195 7290, USA
    J Gen Physiol 124:663-77. 2004
    ..Discovering that one portion of the COOH terminus, the CNBD, can be in the activated configuration while the other portion, the C-linker, is not activated has lead us to suggest a novel modular gating scheme for HCN and CNG channels...
  94. ncbi Identification of conserved prolyl residue important for transport activity and the substrate specificity range of yeast plasma membrane Na+/H+ antiporters
    Olga Kinclova-Zimmermannova
    Department of Membrane Transport, Institute of Physiology AS CR, Prague 4, 142 20, Czech Republic
    J Biol Chem 280:30638-47. 2005
    ..This is the first evidence that a non-polar amino acid residue is important for the substrate specificity and activity of yeast Nha antiporters...
  95. ncbi Betaine tripled the volumetric productivity of D(-)-lactate by Escherichia coli strain SZ132 in mineral salts medium
    S Zhou
    Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA
    Biotechnol Lett 28:671-6. 2006
    ..productivity, and D-lactate tolerance in Escherichia coli B strain SZ132 during batch fermentation in mineral salts medium with 10% (w/v) sugar...
  96. pmc Pore forming polyalkylpyridinium salts from marine sponges versus synthetic lipofection systems: distinct tools for intracellular delivery of cDNA and siRNA
    Debra McLaggan
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    BMC Biotechnol 6:6. 2006
    Haplosclerid marine sponges produce pore forming polyalkylpyridinium salts (poly-APS), which can be used to deliver macromolecules into cells...
  97. ncbi Micronuclei assay and FISH analysis in human lymphocytes treated with six metal salts
    L Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, Universita di Pisa, Pisa, Italy
    Environ Mol Mutagen 34:279-84. 1999
    ..In this investigation, Al (III), Cd (II), Hg (II), Sb (V), Te (VI), and Tl (I) salts were considered...
  98. ncbi Effect of ethanolamine salts and enhancers on the percutaneous absorption of piroxicam from a pressure sensitive adhesive matrix
    Hyun Ah Cheong
    College of Pharmacy, Chosun University, 375 Seosuk dong, Dong Gu, Gwangju 501 759, South Korea
    Eur J Pharm Sci 18:149-53. 2003
    ..studied the effect of permeation enhancers on the skin permeation of piroxicam or piroxicam-ethanolamine (PX-EA) salts from an acrylic adhesive matrix...
  99. pmc Reversibility of beta-amyloid self-assembly: effects of pH and added salts assessed by fluorescence photobleaching recovery
    Nadia J Edwin
    Department of Chemistry and Macromolecular Studies Group, Louisiana State University, Baton Rouge, 70803, USA
    Biomacromolecules 11:341-7. 2010
    ..Oligomeric aggregates were found by fluorescence photobleaching recovery to respond readily to pH and salt conditions. Changing these external cues leads to formation or disassembly of aggregates smaller than 100 nm within minutes...
  100. doi Facile microwave-assisted synthesis of cyclic amidinium salts
    Adila Aidouni
    Center for Education and Research on Macromolecules, Institut de Chimie B6a, Universite de Liege, Sart Tilman par 4000 Liège, Belgium
    J Comb Chem 10:886-92. 2008
    The cyclization of N,N'-dialkyl or diaryl ethane-1,2-diamines or propane-1,3-diamines with inorganic ammonium salts and orthoesters proceeds briskly under microwave irradiation to afford the corresponding imidazolinium or ..
  101. ncbi Cyclodextrin complexes of salts of acidic drugs. Thermodynamic properties, structural features, and pharmaceutical applications
    E Redenti
    R and D Department, Chiesi Farmaceutici s p a, Via Palermo 26 A, 43100 Parma, Italy
    J Pharm Sci 90:979-86. 2001
    ....

Research Grants76

  1. IMMUNOPATHOGENESIS OF BERYLLIUM DISEASE
    Lee Newman; Fiscal Year: 1999
    ..When beryllium-reactive T cells are stimulated with beryllium salts in vitro, gamma-interferon protein and mRNA levels are unusually elevated and unusually sustained, suggesting that ..
  2. LIVER/INTESTINAL METABOLISM ON BILE ACIDS/CHOLESTEROL
    Phillip Hylemon; Fiscal Year: 2001
    ..C isoforms in vivo in liver and ileum (Vlahcevic, Stravitz, Heuman, Hylemon); [2] a) Quantify adsorption of bile salts to model membranes; b) Develop and validate a general quantitative model of bile salt-membrane adsorption; c) ..
  3. LIVER/INTESTINAL METABOLISM ON BILE ACIDS/CHOLESTEROL
    Phillip Hylemon; Fiscal Year: 1999
    ..C isoforms in vivo in liver and ileum (Vlahcevic, Stravitz, Heuman, Hylemon); [2] a) Quantify adsorption of bile salts to model membranes; b) Develop and validate a general quantitative model of bile salt-membrane adsorption; c) ..
  4. LIVER/INTESTINAL METABOLISM ON BILE ACIDS/CHOLESTEROL
    Phillip Hylemon; Fiscal Year: 2000
    ..C isoforms in vivo in liver and ileum (Vlahcevic, Stravitz, Heuman, Hylemon); [2] a) Quantify adsorption of bile salts to model membranes; b) Develop and validate a general quantitative model of bile salt-membrane adsorption; c) ..
  5. Metal Toxicant Effects on Small Heat-Shock Proteins in Kidney Podocytes
    William Smoyer; Fiscal Year: 2001
    ..compounds or occupational or environmental exposure or environmental exposure to inorganic mercury salts. However cadmium has also been reported to induce glomerular disease in addition to its well-known toxicity to ..
  6. A Ribozyme Rescue Strategy for Dry Age-Related Macular Degeneration
    John Sullivan; Fiscal Year: 2009
    ..autofluorescence under blue light excitation due to the dominant presence of toxic bis-retinoid pyridinium salts (A2E) and retinaldehyde dimers (RetDi)...
  7. Understanding the role of bile as a mechanism for improved glucose homeostasis fo
    APRIL DAWN STRADER; Fiscal Year: 2010
    ..in the resolution of type-II diabetes is the exposure of the lower intestine to higher concentrations of bile salts. As mentioned above, the interposed ileum is exposed to high concentrations of biliopancreatic secretions...
  8. Understanding the role of bile as a mechanism for improved glucose homeostasis fo
    APRIL STRADER; Fiscal Year: 2009
    ..in the resolution of type-II diabetes is the exposure of the lower intestine to higher concentrations of bile salts. As mentioned above, the interposed ileum is exposed to high concentrations of biliopancreatic secretions...
  9. Diet and Gastrointestinal Cancer Risk in African Americans and Rural Africans
    STEPHEN O KEEFE; Fiscal Year: 2009
    ..producing bacteria in AAs which are stimulated by high animal fat diets to produce carcinogenic secondary bile salts. In contrast, a high resistant starch diet stimulates mucosal-protective Lactobacillus species were, indeed, found ..
  10. EFFECTS OF BILE ACIDS ON CALCIUM AND IRON ABSORPTION
    Edward Moore; Fiscal Year: 1990
    Several previous studies have shown that whole bile and/or bile salts enhance absorption of both iron and calcium...
  11. Molecular Analysis of NeoAdjuvant Platinum in Triple Negative Breast Cancer
    MARK DANIEL contact PEGRAM; Fiscal Year: 2010
    ..5%) patients had histopathologic confirmation of TNBC. All patients received neoadjuvant platinum salts. Pathologic complete response (pCR) was strictly defined as no residual invasive disease in breast and axilla...
  12. Molecular Analysis of NeoAdjuvant Platinum in Triple Negative Breast Cancer
    Mark Pegram; Fiscal Year: 2009
    ..5%) patients had histopathologic confirmation of TNBC. All patients received neoadjuvant platinum salts. Pathologic complete response (pCR) was strictly defined as no residual invasive disease in breast and axilla...
  13. Development of stable and rapidly acting adjuvanted vaccines for biodefense
    Robert Brey; Fiscal Year: 2009
    ..Most vaccines are formulated in aqueous buffers and suspensions with aluminum salts adjuvants, vaccine immunogens degrade and lose potency (and efficacy)...
  14. Au/Pt Catalysis in the Synthesis of Elaborate N-Heterocycles: Methodology Develop
    Liming Zhang; Fiscal Year: 2010
    ..Au catalysis has attracted tremendous attention lately due to the exceptional capacities of Au salts/complexes in activating alkynes/allenes/alkenes. Pt catalysts, mostly PtCl2, have shown similar reactivities...
  15. Au/Pt Catalysis in the Synthesis of Elaborate N-Heterocycles: Methodology Develop
    Liming Zhang; Fiscal Year: 2009
    ..Au catalysis has attracted tremendous attention lately due to the exceptional capacities of Au salts/complexes in activating alkynes/allenes/alkenes. Pt catalysts, mostly PtCl2, have shown similar reactivities...
  16. MOLECULAR PHYSIOLOGY OF BILIARY LIPID SECRETION
    David Cohen; Fiscal Year: 1999
    ..physicochemical and molecular biological experiments to delineate the hepatocellular mechanisms whereby bile salts promote biliary secretion of cholesterol together with highly specific phosphatidylcholines...
  17. ROLE OF CHLORIDE IN SODIUM-DEPENDENT HYPERTENSION
    Theodore Kurtz; Fiscal Year: 1990
    ..If so, "hidden" sources of dietary Na+, i.e. nonchloride sodium salts such as sodium bicarbonate or ascorbate, may not be as important in the pathogenesis of hypertension as has been ..
  18. CHOLESTEROL SOLUBILIZATION IN BILE
    Sum Lee; Fiscal Year: 1990
    ..lipid with extremely poor water solubility, is solubilized in bile in two different forms - micelles of bile salts, phospholipids and cholesterol, and vesicles of phospholipids and cholesterol...
  19. Reasons for poor durability of resin-dentin bonds
    David H Pashley; Fiscal Year: 2010
    ..We noted that CHX contains biguanide groups that form acidic addition salts with a cationic charge delocated over the five neighboring secondary amine nitrogen atoms of the biguanides...
  20. Reasons for poor durability of resin-dentin bonds
    David Pashley; Fiscal Year: 2009
    ..We noted that CHX contains biguanide groups that form acidic addition salts with a cationic charge delocated over the five neighboring secondary amine nitrogen atoms of the biguanides...
  21. EFFECT OF ELECTROLYTES ON NONIONIC SURFACTANTS
    HANS SCHOTT; Fiscal Year: 1980
    ..Our systematic investigations on the effects of electrolytes on nonionic surfactants have shown that only salts of sodium, potassium and ammonium salt out nonionic surfactants, reducing their solubility...
  22. ION PAIR ALDOL ADDITION REACTIONS
    Andrew Streitwieser; Fiscal Year: 1999
    ..the reaction is now most often run in non-polar solvents, such as tetrahydrofuran (THF), frequently with lithium salts of carbonyl compounds (lithium enolates)...
  23. Diet and Gastrointestinal Cancer Risk in African Americans and Rural Africans
    STEPHEN JD O apos KEEFE; Fiscal Year: 2010
    ..producing bacteria in AAs which are stimulated by high animal fat diets to produce carcinogenic secondary bile salts. In contrast, a high resistant starch diet stimulates mucosal-protective Lactobacillus species were, indeed, found ..
  24. EXPLT BASIS FOR ALCOHOL AND COCAINE STROKES ROLE OF MG2+
    Burton Altura; Fiscal Year: 1991
    ..Preliminary, in-situ experiments indicate that administration of Mg salts results in dose-dependent inhibition of the alcohol and cocaine-induced cerebral microvascular spasms and ..
  25. Male Subfertility By Ni2+ Poisoning of Ca2+ Channels ?
    Susan Benoff; Fiscal Year: 2000
    Nickel is widely used in steel alloys and as metal plate. Nickel salts are well-recognized as allergens and carcinogens...
  26. Male Subfertility By Ni2+ Poisoning of Ca2+ Channels ?
    Susan Benoff; Fiscal Year: 2001
    Nickel is widely used in steel alloys and as metal plate. Nickel salts are well-recognized as allergens and carcinogens...
  27. EXPLT BASIS FOR ALCOHOL AND COCAINE STROKES ROLE OF MG2+
    Burton Altura; Fiscal Year: 1990
    ..Preliminary, in-situ experiments indicate that administration of Mg salts results in dose-dependent inhibition of the alcohol and cocaine-induced cerebral microvascular spasms and ..
  28. EXPLT BASIS FOR ALCOHOL AND COCAINE STROKES ROLE OF MG2+
    Burton Altura; Fiscal Year: 1992
    ..Preliminary, in-situ experiments indicate that administration of Mg salts results in dose-dependent inhibition of the alcohol and cocaine-induced cerebral microvascular spasms and ..
  29. EXPLT BASIS FOR ALCOHOL AND COCAINE STROKES ROLE OF MG2+
    Burton Altura; Fiscal Year: 1993
    ..Preliminary, in-situ experiments indicate that administration of Mg salts results in dose-dependent inhibition of the alcohol and cocaine-induced cerebral microvascular spasms and ..
  30. MOLECULAR PHYSIOLOGY OF BILIARY LIPID SECRETION
    David Cohen; Fiscal Year: 2000
    ..physicochemical and molecular biological experiments to delineate the hepatocellular mechanisms whereby bile salts promote biliary secretion of cholesterol together with highly specific phosphatidylcholines...
  31. CHEMOSENSORY TRANSDUCTION IN TASTE CELLS
    Stephen Roper; Fiscal Year: 1992
    ..The project will focus on how two specific classes of chemical stimuli, acids and calcium salts, affect taste receptor cells. These are both important taste stimuli in man and animals...
  32. NEURAL CONTROL OF THE GALLBLADDER
    Gary M Mawe; Fiscal Year: 2010
    ..Recent reports suggest that decreased gallbladder motility is caused by elevated cholesterol and hydrophobic salts in the bile, and that ensuing inflammation and impairments in gallbladder emptying lead to stone formation...
  33. NEURAL CONTROL OF THE GALLBLADDER
    Gary Mawe; Fiscal Year: 2009
    ..Recent reports suggest that decreased gallbladder motility is caused by elevated cholesterol and hydrophobic salts in the bile, and that ensuing inflammation and impairments in gallbladder emptying lead to stone formation...
  34. DNA and RNA Stability in Glycine Betaine, TMAO, and Urea Solutions: Correlating S
    JEFFREY JAMES contact SCHWINEFUS; Fiscal Year: 2010
    ..provided by applicant): Cellular biochemical reactions involving nucleic acids occur in aqueous solutions of salts, cosolutes, and biopolymers, such as proteins...
  35. Raman spectroscopy probes for assisting stereotactic breast biopsy needle placeme
    Stephen Fulghum; Fiscal Year: 2009
    ..Microcalcifications are small, solid deposits of calcium salts, often associated with cancerous lesions, which strongly absorb x-rays and thus show up as high-contrast shadows ..
  36. HEPATIC PATHWAYS OF HEME AND BILIRUBIN METABOLISM
    John Gollan; Fiscal Year: 1990
    ..Specifically, the role of membranes as a medium for the intracellular transport of lipophilic substrates and bile salts will be studied using native E.R. and model membranes, and an ultra-rapid filtration system...
  37. HEPATIC PATHWAYS OF HEME AND BILIRUBIN METABOLISM
    John Gollan; Fiscal Year: 1993
    ..Specifically, the role of membranes as a medium for the intracellular transport of lipophilic substrates and bile salts will be studied using native E.R. and model membranes, and an ultra-rapid filtration system...
  38. METABOLISM OF APO-E-RICH HDL BY HEPATIC LIPASE
    B Waite; Fiscal Year: 1993
    ..to regulate the balance of dietary cholesterol intake, cholesterol synthesis and cholesterol excretion as bile salts leads to hypercholesterolemia and atherosclerosis...
  39. DEVELOPING SOLUTES AS STRUCTURAL/MECHANISTIC PROBES OF PROTEIN-DNA INTERACTIONS
    M Thomas Record; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Biochemically-significant small molecules (Hofmeister salts, osmolytes, denaturants, collectively referred to as solutes) exert often large, specific effects on fundamental biological processes ..
  40. DEVELOPING SOLUTES AS STRUCTURAL/MECHANISTIC PROBES OF PROTEIN-DNA INTERACTIONS
    M Thomas Record; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Biochemically-significant small molecules (Hofmeister salts, osmolytes, denaturants, collectively referred to as solutes) exert often large, specific effects on fundamental biological processes ..
  41. New Methods for the Expedited Synthesis of C11 and F18 PET Tracers
    Salvatore D Lepore; Fiscal Year: 2010
    ..of a new class of reactive entities that are uniquely activated by metal cations that form part of the nuclide salts most often used in the synthesis of PET agents (e.g. K18F and K11CN)...
  42. SENSORY CODING IN TASTE
    David Smith; Fiscal Year: 1999
    ..Adapted From The Investigator s Abstract): Recent studies have provided insights into the transduction of sodium salts and acids by taste receptor cells and the organization of chemical sensitivities in neurons of the afferent ..
  43. SENSORY CODING IN TASTE
    David Smith; Fiscal Year: 2000
    ..Adapted From The Investigator s Abstract): Recent studies have provided insights into the transduction of sodium salts and acids by taste receptor cells and the organization of chemical sensitivities in neurons of the afferent ..
  44. PROTEIN INHIBITORS OF CALCIUM PHOSPHATE PRECIPITATION
    David Schlesinger; Fiscal Year: 1990
    Human saliva is highly supersaturated with respect to basic calcium phosphate salts. However, precipitation of these salts from saliva and crystal growth of calcium phosphates onto dental enamel do not occur under normal physiological ..
  45. EFFECT OF MUCIN HYPERSECRETION ON GALLBLADDER PHYSIOLOGY
    Mitchell Shiffman; Fiscal Year: 1991
    ..aims of the present study are: 1) to determine if GBM acts as a barrier to the diffusion of electrolytes, bile salts and biliary lipids; 2) to determine if this barrier property alters the ability of the GB to modify GB bile; and 3)..
  46. DEVELOPMENT OF THE SENSE OF TASTE
    Charlotte Mistretta; Fiscal Year: 1993
    ..of the taste system in mammals, there is a striking increase in neural responsiveness to NaCl compared to other salts. Developmental differences in salt taste responses are accompanied by neural rearrangements that alter number of ..
  47. DEVELOPMENT OF THE SENSE OF TASTE
    Charlotte Mistretta; Fiscal Year: 1990
    ..of the taste system in mammals, there is a striking increase in neural responsiveness to NaCl compared to other salts. Developmental differences in salt taste responses are accompanied by neural rearrangements that alter number of ..
  48. DEVELOPMENT OF THE SENSE OF TASTE
    Charlotte Mistretta; Fiscal Year: 1991
    ..of the taste system in mammals, there is a striking increase in neural responsiveness to NaCl compared to other salts. Developmental differences in salt taste responses are accompanied by neural rearrangements that alter number of ..
  49. DEVELOPMENT OF THE SENSE OF TASTE
    Charlotte Mistretta; Fiscal Year: 1992
    ..of the taste system in mammals, there is a striking increase in neural responsiveness to NaCl compared to other salts. Developmental differences in salt taste responses are accompanied by neural rearrangements that alter number of ..
  50. MECHANISMS OF BILE SALT MEDIATED CHOLESTEROL ABSORPTION
    Patrick Tso; Fiscal Year: 2001
    Previous data from other laboratories as well as ours demonstrated that bile salts play an important role in the absorption of cholesterol by the small intestine and its role extends beyond the solubilization of cholesterol...
  51. MECHANISMS OF BILE SALT MEDIATED CHOLESTEROL ABSORPTION
    Patrick Tso; Fiscal Year: 2000
    Previous data from other laboratories as well as ours demonstrated that bile salts play an important role in the absorption of cholesterol by the small intestine and its role extends beyond the solubilization of cholesterol...
  52. MECHANISMS OF BILE SALT MEDIATED CHOLESTEROL ABSORPTION
    Patrick Tso; Fiscal Year: 2002
    Previous data from other laboratories as well as ours demonstrated that bile salts play an important role in the absorption of cholesterol by the small intestine and its role extends beyond the solubilization of cholesterol...
  53. The Critical Role of Bile Salts:Gut Protection in Critical Illness
    Eric Strauch; Fiscal Year: 2009
    Our objective is to show that bile salts have significant beneficial effects on the intestinal mucosa, through the activation of the transcription factors c-myc and NF-:B...
  54. MECHANISMS OF BILE SALT MEDIATED CHOLESTEROL ABSORPTION
    Patrick Tso; Fiscal Year: 1999
    Previous data from other laboratories as well as ours demonstrated that bile salts play an important role in the absorption of cholesterol by the small intestine and its role extends beyond the solubilization of cholesterol...
  55. Preclinical development of a novel antibacterial for Clostridium difficile diseas
    George E Wright; Fiscal Year: 2010
    ..Compound 359E and analogs are tertiary amines, readily form water soluble salts, and are highly effective against Cdiff in vitro and in vivo...
  56. Protein Stabilization in Ionic Liquids
    Gloria Elliott; Fiscal Year: 2009
    ..ILs are synthesized from imidazolium-based actions and highly fluorinated anions, ILs can also be formulated from salts, sugars, amino acids, and biomolecules that exist in nature - many of which have already been approved as ..
  57. LIVER/INTESTINAL METABOLISM OF BILE ACIDS AND LIPIDS
    ZDRAVKO VLAHCEVIC; Fiscal Year: 1992
    ..formation of secondary bile acids by intestinal bacteria; and c) determine the mechanism by which hydrophobic bile salts cause cell injury and explore the basis for hepatoprotective action of ursodeoxycholate...
  58. NORMAL & PATHOLOGICAL ENAMEL MINERALIZATION
    Takaaki Aoba; Fiscal Year: 1990
    ..pathological enamel mineralization is to determine: a) the driving force for precipitation of calcium phosphate salts during amelogenesis, b) the cellular role in establishing such a driving force, and c) the possible regulatory ..
  59. MYOGENIC DISORDERS OF THE GALLBLADDER
    Jose Behar; Fiscal Year: 2001
    ..will study the myogenic abnormalities responsible for creating this GB environment and examine hydrophobic bile salts and reactive oxygen species (ROS) as possible aggressive factors...
  60. MYOGENIC DISORDERS OF THE GALLBLADDER
    Jose Behar; Fiscal Year: 2002
    ..will study the myogenic abnormalities responsible for creating this GB environment and examine hydrophobic bile salts and reactive oxygen species (ROS) as possible aggressive factors...
  61. HEPATOCELLULAR TRANSPORT OF SMALL HYDROPHOBIC COMPOUNDS
    STEPHEN ZUCKER; Fiscal Year: 1991
    ..g. bilirubin) and other small hydrophobic molecular species (e.g. bile salts) are transported within the hepatocyte and, specifically, to delineate the role of intracellular membranes and ..