oxygen radioisotopes

Summary

Summary: Unstable isotopes of oxygen that decay or disintegrate emitting radiation. O atoms with atomic weights 13, 14, 15, 19, and 20 are radioactive oxygen isotopes.

Top Publications

  1. pmc Automatic generation of absolute myocardial blood flow images using [15O]H2O and a clinical PET/CT scanner
    Hendrik J Harms
    Department of Nuclear Medicine and PET Research, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 38:930-9. 2011
  2. ncbi Parametric imaging of myocardial blood flow with 15O-water and PET using the basis function method
    Hiroshi Watabe
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, Osaka, Japan
    J Nucl Med 46:1219-24. 2005
  3. ncbi Human cerebral circulation: positron emission tomography studies
    Hiroshi Ito
    Department of Nuclear Medicine and Radiology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Ann Nucl Med 19:65-74. 2005
  4. ncbi Evaluation of basis function and linear least squares methods for generating parametric blood flow images using 15O-water and Positron Emission Tomography
    Ronald Boellaard
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    Mol Imaging Biol 7:273-85. 2005
  5. doi Myocardial perfusion quantitation with 15O-labelled water PET: high reproducibility of the new cardiac analysis software (Carimas)
    Sergey V Nesterov
    Turku PET Centre, University of Turku, P O Box 52, Turku, 20521, Finland
    Eur J Nucl Med Mol Imaging 36:1594-602. 2009
  6. ncbi Development of motion correction technique for cardiac (15)O-water PET study using an optical motion tracking system
    Kazuhiro Koshino
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Ann Nucl Med 24:1-11. 2010
  7. ncbi Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET: comparison with 15O-labelled water PET
    Keiichiro Yoshinaga
    Department of Photobiology, Division of Molecular Cellular Imaging, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, Hokkaido, Japan
    Eur J Nucl Med Mol Imaging 37:2233-41. 2010
  8. doi Parametric images of myocardial viability using a single 15O-H2O PET/CT scan
    Hendrik J Harms
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 52:745-9. 2011
  9. ncbi Low-dose quantitative myocardial blood flow imaging using 15O-water and PET without attenuation correction
    Mark Lubberink
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Nucl Med 51:575-80. 2010
  10. ncbi Rapid quantitative measurement of CMRO(2) and CBF by dual administration of (15)O-labeled oxygen and water during a single PET scan-a validation study and error analysis in anesthetized monkeys
    Nobuyuki Kudomi
    Department of Investigative Radiology, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Fujishirodai, Suita, Osaka, Japan
    J Cereb Blood Flow Metab 25:1209-24. 2005

Detail Information

Publications141 found, 100 shown here

  1. pmc Automatic generation of absolute myocardial blood flow images using [15O]H2O and a clinical PET/CT scanner
    Hendrik J Harms
    Department of Nuclear Medicine and PET Research, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 38:930-9. 2011
    ..The aim of this study was to develop a method for generating reproducible, high-quality and quantitative parametric MBF images with minimal user intervention...
  2. ncbi Parametric imaging of myocardial blood flow with 15O-water and PET using the basis function method
    Hiroshi Watabe
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, Osaka, Japan
    J Nucl Med 46:1219-24. 2005
    ..The basis function method linearizes the solution of the 1-tissue-compartment model, which results in a computationally much faster method than the conventional nonlinear least-squares fitting method in estimating the parameters...
  3. ncbi Human cerebral circulation: positron emission tomography studies
    Hiroshi Ito
    Department of Nuclear Medicine and Radiology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Ann Nucl Med 19:65-74. 2005
    ..These findings should be considered in future studies of the pathophysiology of cerebrovascular diseases...
  4. ncbi Evaluation of basis function and linear least squares methods for generating parametric blood flow images using 15O-water and Positron Emission Tomography
    Ronald Boellaard
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    Mol Imaging Biol 7:273-85. 2005
    ..In this paper the performance of basis function and linear least squares methods for generating parametric flow data were evaluated...
  5. doi Myocardial perfusion quantitation with 15O-labelled water PET: high reproducibility of the new cardiac analysis software (Carimas)
    Sergey V Nesterov
    Turku PET Centre, University of Turku, P O Box 52, Turku, 20521, Finland
    Eur J Nucl Med Mol Imaging 36:1594-602. 2009
    ..The goal of this study was to assess the reproducibility of results the package provides for myocardial perfusion (MP) quantitation using (15)O-labelled water...
  6. ncbi Development of motion correction technique for cardiac (15)O-water PET study using an optical motion tracking system
    Kazuhiro Koshino
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Ann Nucl Med 24:1-11. 2010
    ..We developed a motion correction system using an optical motion-tracking device to detect a subject's global movement for cardiac study...
  7. ncbi Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET: comparison with 15O-labelled water PET
    Keiichiro Yoshinaga
    Department of Photobiology, Division of Molecular Cellular Imaging, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, Hokkaido, Japan
    Eur J Nucl Med Mol Imaging 37:2233-41. 2010
    ....
  8. doi Parametric images of myocardial viability using a single 15O-H2O PET/CT scan
    Hendrik J Harms
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 52:745-9. 2011
    ..The aim of this study was to generate parametric PTI images from a (15)O-H(2)O PET/CT scan without an additional (15)O-CO scan...
  9. ncbi Low-dose quantitative myocardial blood flow imaging using 15O-water and PET without attenuation correction
    Mark Lubberink
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Nucl Med 51:575-80. 2010
    ..The purpose of the present study was to assess the accuracy of these MBF measurements in the absence of attenuation correction...
  10. ncbi Rapid quantitative measurement of CMRO(2) and CBF by dual administration of (15)O-labeled oxygen and water during a single PET scan-a validation study and error analysis in anesthetized monkeys
    Nobuyuki Kudomi
    Department of Investigative Radiology, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Fujishirodai, Suita, Osaka, Japan
    J Cereb Blood Flow Metab 25:1209-24. 2005
    ..These results show that this fast technique has an ability for accurate assessment of CBF/CMRO(2) and also allows multiple assessment at different physiologic conditions...
  11. ncbi Accuracy of a method using short inhalation of (15)O-O(2) for measuring cerebral oxygen extraction fraction with PET in healthy humans
    Naoya Hattori
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Nucl Med 45:765-70. 2004
    ..The purpose of this study was to test the accuracy of the short-inhalation technique for estimating OEF in healthy human volunteers...
  12. ncbi Assessment of myocardial perfusion by dynamic O-15-labeled water PET imaging: validation of a new fast factor analysis
    Itaru Adachi
    Department of Medical Radiology, University Hospital Zurich, Zurich, Switzerland
    J Nucl Cardiol 14:698-705. 2007
    ..Conventional FA methods generating images from sinograms (sinoFA) are time-consuming, whereas FA can be performed on the reconstructed images (reconFA) in a fraction of time. We validated the MBF values obtained by reconFA versus sinoFA...
  13. ncbi Perfusable tissue index obtained by positron emission tomography as a marker of myocardial viability in patients with ischemic ventricular dysfunction
    Hideki Itoh
    Department of Cardiology, Kanazawa Cardiovascular Hospital and Kanazawa University, Japan
    Circ J 66:341-4. 2002
    ..038, p<0.0001) and was similar to that of the control segments. After revascularization, the PTI correlated with the SD of wall motion (p<0.05, r=0.58). PTI may be a good predictor of contractile recovery after revascularization...
  14. ncbi Improvement of algorithm for quantification of regional myocardial blood flow using 15O-water with PET
    Chietsugu Katoh
    Department of Tracer Kinetics, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    J Nucl Med 45:1908-16. 2004
    ..Subsequently, a uniform input function was calculated for each subject using a time-activity curve in the 3D whole myocardial ROI. The uniform input function allows the mathematically simple and robust algorithm to estimate rMBF...
  15. ncbi Motion detection and correction for dynamic ( 15)O-water myocardial perfusion PET studies
    Alexandru Naum
    Turku PET Centre, University of Turku, P O Box 52, 20521 Turku, Finland
    Eur J Nucl Med Mol Imaging 32:1378-83. 2005
    ....
  16. ncbi The perfusable tissue index: a marker of myocardial viability
    Paul Knaapen
    Department of Cardiology, University Medical Center, Amsterdam, The Netherlands
    J Nucl Cardiol 10:684-91. 2003
  17. ncbi Intersubject variability and reproducibility of 15O PET studies
    Jonathan P Coles
    The Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 26:48-57. 2006
    ..While ideally each centre should develop its own bank of such data, the figures provided will allow initial generic approximations of sample size for such studies...
  18. ncbi Blood flow and metabolism in locally advanced breast cancer: relationship to response to therapy
    David A Mankoff
    Division of Nuclear Medicine, Box 346113, University of Washington, 1959 E Pacific Street, Seattle, WA 98195, USA
    J Nucl Med 43:500-9. 2002
    ....
  19. ncbi Quantitative cerebral H2(15)O perfusion PET without arterial blood sampling, a method based on washout rate
    Valerie Treyer
    PET Center, Division of Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    Eur J Nucl Med Mol Imaging 30:572-80. 2003
    ..It does not require arterial blood sampling, yields quantitative voxel-by-voxel maps of rCBF, and is computationally efficient and easy to implement...
  20. ncbi Measurement of left ventricular volumes and function with O-15-labeled carbon monoxide gated positron emission tomography: comparison with magnetic resonance imaging
    Hadassa A Hofman
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Cardiol 12:639-44. 2005
    ..The aim of this study was to compare LV volumes and function as measured by routinely acquired blood pool images by use of gated O-15-labeled CO PET with the reference technique, cardiovascular magnetic resonance imaging (MRI)...
  21. doi Quantitative parametric perfusion images using 15O-labeled water and a clinical PET/CT scanner: test-retest variability in lung cancer
    Astrid A M van der Veldt
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 51:1684-90. 2010
    ..The purpose of the present study was to assess validity and reproducibility of dynamic H(2)(15)O PET/CT scans for measuring tumor perfusion and validate the quantitative accuracy of parametric perfusion images...
  22. ncbi Quantitative comparison of the bolus and steady-state methods for measurement of cerebral perfusion and oxygen metabolism: positron emission tomography study using 15O-gas and water
    H Okazawa
    PET Unit, Research Institute, Shiga Medical Center, Moriyama, Japan
    J Cereb Blood Flow Metab 21:793-803. 2001
    ..Increase in CBV without a change in V0 suggested the increase might mainly be caused by venous dilatation in the ischemic regions...
  23. pmc Low radiation dose imaging of myocardial perfusion and coronary angiography with a hybrid PET/CT scanner
    S Kajander
    Turku PET Centre, Turku, Finland
    Clin Physiol Funct Imaging 29:81-8. 2009
    ..To test the image quality and feasibility of a sequential low radiation dose protocol for hybrid cardiac PET/CT angiography (CTA)...
  24. ncbi Quantification of subendocardial and subepicardial blood flow using 15O-labeled water and PET: experimental validation
    Ornella Rimoldi
    Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, United Kingdom
    J Nucl Med 47:163-72. 2006
    ....
  25. ncbi Absolute quantification of myocardial blood flow with H(2)(15)O and 3-dimensional PET: an experimental validation
    Klaus P Schafers
    Medical Research Council Clinical Sciences Centre and National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, United Kingdom
    J Nucl Med 43:1031-40. 2002
    ..The purpose of this study was to assess a 3-dimensional (3D)-only PET scanner (ECAT EXACT3D) for its use in the absolute quantification of myocardial blood flow (MBF) using H(2)(15)O...
  26. ncbi Coupling of porcine bone blood flow and metabolism in high-turnover bone disease measured by [(15)O]H(2)O and [(18)F]fluoride ion positron emission tomography
    Morand Piert
    Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, Germany
    Eur J Nucl Med Mol Imaging 29:907-14. 2002
    ..The increased bone metabolism in high-turnover bone disease after gastrectomy is mainly related to an up-regulation of the amount of ionic exchange of [(18)F]fluoride with the bone matrix, while tracer delivery remains unchanged...
  27. ncbi Quantification of regional myocardial blood flow using dynamic H2(15)O PET and factor analysis
    J Y Ahn
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Nucl Med 42:782-7. 2001
    ..93). CONCLUSION: rMBF can be measured robustly by factor analysis using dynamic myocardial H2(15)O PET images without additional C15O blood-pool PET...
  28. ncbi Assessment of hypoxia and perfusion in human brain tumors using PET with 18F-fluoromisonidazole and 15O-H2O
    Matthias Bruehlmeier
    Paul Scherrer Institute, Center for Radiopharmaceutical Science, Villigen, Switzerland
    J Nucl Med 45:1851-9. 2004
    ..Hypoxia predicts poor treatment response of malignant tumors. We used PET with (18)F-fluoromisonidazole ((18)F-FMISO) and (15)O-H(2)O to measure in vivo hypoxia and perfusion in patients with brain tumors...
  29. ncbi Reduction of coronary flow reserve in areas with and without ischemia on stress perfusion imaging in patients with coronary artery disease: a study using oxygen 15-labeled water PET
    Keiichiro Yoshinaga
    Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Nucl Cardiol 10:275-83. 2003
    ..We evaluated coronary flow reserve (CFR) using oxygen 15-labeled water in areas with and without ischemia on technetium 99m tetrofosmin stress perfusion SPECT in patients with angiographically documented CAD...
  30. ncbi A PET study after treatment with an anxiety-provoking agent, m-chlorophenyl-piperazine, in conscious rhesus monkeys
    Hiroyuki Takamatsu
    Medical and Pharmacological Research Center Foundation, Inoyama Town, Hakui City, Ishikawa, Japan
    J Nucl Med 44:1516-21. 2003
    ....
  31. ncbi Activation of a residual cortical network during painful stimulation in long-term postanoxic vegetative state: a 15O-H2O PET study
    Jan Kassubek
    Department of Neurology, University of Freiburg, Breisacher Str 64, Freiburg, 79106 Germany
    J Neurol Sci 212:85-91. 2003
    ..In conclusion, the regional activity found at the cortical level indicates that a residual pain-related cerebral network remains active in long-term PVS patients...
  32. ncbi Changes in human cerebral blood flow and myocardial blood flow during mental stress measured by dual positron emission tomography
    Hiroshi Ito
    Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Ann Nucl Med 17:381-6. 2003
    ..Sympathetic stimulation is reported to cause cerebral vasoconstriction and reduce CBF in animals. Although such a sympathetic response was observed in relation to mental stress, no significant change in CBF was observed in our subjects...
  33. ncbi Generation of parametric image of regional myocardial blood flow using H(2)(15)O dynamic PET and a linear least-squares method
    Jae Sung Lee
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Nucl Med 46:1687-95. 2005
    ....
  34. ncbi Effect of regional tracer delay on CBF in healthy subjects measured with dynamic susceptibility contrast-enhanced MRI: comparison with 15O-PET
    Masanobu Ibaraki
    Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, 6 10 Senshu Kubota machi, Akita 010 0874, Japan
    Magn Reson Med Sci 4:27-34. 2005
    ..SVD-CBFs with and without correction for the delay were compared with CBF measured by positron emission tomography (PET-CBF), which is regarded as the gold standard for quantification of CBF...
  35. ncbi Pharmacological modulation of prefrontal cortical activity during a working memory task in young and older humans: a PET study with physostigmine
    Ulderico Freo
    Laboratory of Clinical Biochemistry, Medical School, University of Pisa, Via Roma, 55, I 56126 Pisa, Italy
    Am J Psychiatry 162:2061-70. 2005
    ..The current study was designed to determine how healthy aging influences the neural response to working memory before and during pharmacological potentiation of the cholinergic system...
  36. ncbi Acute changes in regional cerebral (18)F-FDG kinetics in patients with traumatic brain injury
    Naoya Hattori
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 6948, USA
    J Nucl Med 45:775-83. 2004
    ..The purpose of this study was to characterize contusional, pericontusional, and remote regions of TBI by estimating glucose transporter and hexokinase activities on the basis of (18)F-FDG kinetic modeling...
  37. ncbi Sequential H(2)(15)O PET studies in baboons: before and after amphetamine
    Julie C Price
    Department of Radiology, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Nucl Med 43:1090-100. 2002
    ..A common assumption in bolus injection PET studies of this type is that cerebral blood flow (CBF) does not vary during the scan. The goal of this work was to examine the effect of AMPH administration on sequential PET measures of CBF...
  38. ncbi Defining ischemic burden after traumatic brain injury using 15O PET imaging of cerebral physiology
    Jonathan P Coles
    The Division of Anesthesia, and The Wolfson Brain Imaging Center, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 24:191-201. 2004
    ..We conclude that this technique is a valid and useful tool for quantifying ischemic burden after traumatic brain injury...
  39. ncbi Spectral analysis of 99mTc-HMPAO for estimating cerebral blood flow: a comparison with H2(15)O PET
    Masashi Takasawa
    Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Japan
    Ann Nucl Med 18:243-9. 2004
    ..The SA method should be especially useful for activation studies involving pharmacological intervention and/or clinical cases with an increased CBF...
  40. ncbi Brain blood-flow alterations induced by therapeutic vagus nerve stimulation in partial epilepsy: II. prolonged effects at high and low levels of stimulation
    Thomas R Henry
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Epilepsia 45:1064-70. 2004
    ..To measure vagus nerve stimulation (VNS)-induced cerebral blood flow (CBF) effects after prolonged VNS and to compare these effects with immediate VNS effects on CBF...
  41. ncbi Regional cerebral blood flow responses to smoking in tobacco smokers after overnight abstinence
    Jon Kar Zubieta
    Department of Psychiatry, Mental Health Research Institute, 205 Zina Pitcher Pl, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Am J Psychiatry 162:567-77. 2005
    ..The purpose of the study was to determine the effects of cigarette smoking on brain regional function in a group of chronic smokers by using cerebral blood flow (CBF) measures and positron emission tomography (PET)...
  42. ncbi Common and constrasting areas of activation for abstract and concrete concepts: an H2 15O PET study
    Christine Whatmough
    Lady Davis Institutue and McGill University, Montreal, Quebec, Canada
    J Cogn Neurosci 16:1211-26. 2004
    ..Increased processing complexity may proceed in a posterior-anterior direction in the lateral temporal cortex...
  43. ncbi Determination of kinetic rate constants for 2-[18F]fluoro-2-deoxy-D-glucose and partition coefficient of water in conscious macaques and alterations in aging or anesthesia examined on parametric images with an anatomic standardization technique
    Akihiro Noda
    Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan
    J Cereb Blood Flow Metab 23:1441-7. 2003
    ..The occipital cortex was also the most affected region. The tissue-blood partition coefficient of water was decreased globally...
  44. pmc Neural correlates of the emergence of consciousness of thirst
    Gary Egan
    The Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria 3010, Australia
    Proc Natl Acad Sci U S A 100:15241-6. 2003
    ....
  45. ncbi Cerebral and cerebellar activation in power and precision grip movements: an H2 15O positron emission tomography study
    Masashi Takasawa
    Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka, Japan
    J Cereb Blood Flow Metab 23:1378-82. 2003
    ..Our findings indicate no difference in brain activation between the acts of power grip and precision grip without a target object...
  46. ncbi Assessment of myocardial blood flow using 15O-water and 1-11C-acetate in rats with small-animal PET
    Pilar Herrero
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 47:477-85. 2006
    ..This feasibility study was undertaken to determine whether myocardial blood flow (MBF, mL/g/min) could be quantified noninvasively in small rodents using microPET and 15O-water or 1-11C-acetate...
  47. ncbi Direct comparison between 2-dimensional and 3-dimensional PET acquisition modes for myocardial blood flow absolute quantification with O-15 water and N-13 ammonia
    Véronique Roelants
    Department of Nuclear Medicine, Universite Catholique de Louvain, Cliniques Universitaires St Luc, Brussels, Belgium
    J Nucl Cardiol 13:220-4. 2006
    ..The study aim was to directly compare 2D and 3D acquisition modes for the evaluation of absolute myocardial blood flow (MBF) over a wide range of flow values...
  48. ncbi Quantitative measurement of regional cerebrovascular reactivity to acetazolamide using 123I-N-isopropyl-p-iodoamphetamine autoradiography with SPECT: validation study using H2 15O with PET
    Kuniaki Ogasawara
    Department of Neurosurgery, Iwate Medical University, 19 1 Uchimaru, Morioka 020 8505, Japan
    J Nucl Med 44:520-5. 2003
    ..To validate the accuracy of (123)I-IMP-ARG for quantifying regional cerebrovascular reactivity (rCVR) to acetazolamide, we compared rCVR determined using (123)I-IMP-ARG with that determined using H(2)(15)O PET...
  49. ncbi Accuracy of PET in predicting functional recovery after revascularisation in patients with chronic ischaemic dysfunction: head-to-head comparison between blood flow, glucose utilisation and water-perfusable tissue fraction
    Jeroen J Bax
    Leiden University Medical Center, The Netherlands
    Eur J Nucl Med Mol Imaging 29:721-7. 2002
    ..It is concluded that metabolic imaging is superior to perfusion-based indexes for assessment of the potential for functional recovery after revascularisation...
  50. ncbi Impairment of nonverbal recognition in Alzheimer disease: a PET O-15 study
    K E Anderson
    Cognitive Neuroscience Division, Taub Institute for Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Neurology 69:32-41. 2007
    ..To characterize deficits in nonverbal recognition memory and functional brain changes associated with these deficits in Alzheimer disease (AD)...
  51. ncbi Paralimbic and medial prefrontal cortical involvement in neuroendocrine responses to traumatic stimuli
    Israel Liberzon
    Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USA
    Am J Psychiatry 164:1250-8. 2007
    ..The authors used [(15)O]H(2)O positron emission tomography (PET) on subjects with posttraumatic stress disorder (PTSD) to study these circuits...
  52. ncbi Gray matter blood flow change is unevenly distributed during moderate isocapnic hypoxia in humans
    Andrew P Binks
    University of New England, Portland, Maine, USA
    J Appl Physiol (1985) 104:212-7. 2008
    ..This may be relevant to conditions such as altitude, breath-hold diving, and obstructive sleep apnea, and may have implications for functional brain imaging studies that involve hypoxia...
  53. ncbi Validation of myocardial perfusion reserve measurements using regularized factor images of H(2)(15)O dynamic PET scans
    F Frouin
    , , , Paris, France
    J Nucl Med 42:1737-46. 2001
    ..The method reduces exposure to radiation and examination time and lowers the cost of MPR protocols using a PET scanner...
  54. ncbi Age-related changes in muscarinic cholinergic receptors in the living brain: a PET study using N-[11C]methyl-4-piperidyl benzilate combined with cerebral blood flow measurement in conscious monkeys
    T Kakiuchi
    Central Research Laboratory, Hamamatsu Photonics K.K, 5000 Hirakuchi, Hamakita, Shizuoka 434-8601, Japan
    Brain Res 916:22-31. 2001
    ....
  55. ncbi Cochlear implant benefits in deafness rehabilitation: PET study of temporal voice activations
    Arnaud Coez
    CEA INSERM U797 Research Unit Neuroimaging and Psychiatry, Service Hospitalier Frederic Joliot, IFR49, Orsay, France
    J Nucl Med 49:60-7. 2008
    ..To test this hypothesis, we studied the activation of human temporal voice areas (TVA) using a well-standardized PET paradigm adapted from previous functional MRI (fMRI) studies...
  56. ncbi Constant-infusion H(2)15O PET and acetazolamide challenge in the assessment of cerebral perfusion status
    Bruno Weber
    Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
    J Nucl Med 45:1344-50. 2004
    ..There is considerable discrepancy regarding the optimal time point of imaging after ACZ injection. The purpose of this study was to continuously monitor cerebral blood flow (CBF) after ACZ using constant-infusion H(2)(15)O PET...
  57. ncbi Blood-to-brain glucose transport, cerebral glucose metabolism, and cerebral blood flow are not increased after hypoglycemia
    S A Segel
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Diabetes 50:1911-7. 2001
    ..They do not exclude regional increments in blood-to-brain glucose transport. Alternatively, the fundamental alteration might lie beyond the blood-brain barrier...
  58. ncbi Can [15O]water be used to evaluate drugs?
    P Herscovitch
    PET Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    J Clin Pharmacol . 2001
    ..Numerous investigators have successfully applied the method to study a wide variety of centrally acting drugs. In summary, then, the answer to the question, "Can [15O]water be used to evaluate drugs?" is a definitive yes...
  59. ncbi Effect of vascular radioactivity on regional values of cerebral blood flow: evaluation of methods for H(2)(15)O PET to distinguish cerebral perfusion from blood volume
    H Okazawa
    McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Canada
    J Nucl Med 42:1032-9. 2001
    ..The 3-WI method could provide rCBF values that are less influenced by vascular radioactivity and also show differences in V(0) in PET activation studies...
  60. ncbi Acute effect of 3-(4-acetamido)-butyrril-lorazepam (DDS2700) on brain function assessed by PET at rest and during attentive tasks
    R M Moresco
    INB-CNR, University of Milan-Statale, University of Milan-Bicocca, H. S. Raffaele, Milano, Italy
    Nucl Med Commun 22:399-404. 2001
    ..PET assessment by [18F]FDG and water may provide complementary information in pharmacodynamic studies...
  61. ncbi Separation of input function for rapid measurement of quantitative CMRO2 and CBF in a single PET scan with a dual tracer administration method
    Nobuyuki Kudomi
    Department of Investigative Radiology, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, 5 7 1, Fujishirodai, Suita, Osaka 565 8565, Japan
    Phys Med Biol 52:1893-908. 2007
    ..We concluded that the present calculation based methods could be of use for quantitatively calculating CBF and CMRO(2) with the DARG approach...
  62. ncbi Effects of levodopa infusion on motor activation responses in Parkinson's disease
    A Feigin
    Center for Neurosciences, North Shore LIJ Research Institute, Manhasset, NY 11030, USA
    Neurology 59:220-6. 2002
    ..In this study, the authors used PET to assess the effects of levodopa on motor activation responses and determined how these changes related to on-line recordings of movement speed and accuracy...
  63. ncbi Database of normal human cerebral blood flow measured by SPECT: I. Comparison between I-123-IMP, Tc-99m-HMPAO, and Tc-99m-ECD as referred with O-15 labeled water PET and voxel-based morphometry
    Hiroshi Ito
    Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Ann Nucl Med 20:131-8. 2006
    ..The regional distribution of tissue fractions of gray matter determined by voxel-based morphometry was also compared with SPECT and PET CBF distributions...
  64. ncbi Effects of left ventricular volume and ejection on myocardial blood flow measured by oxygen-15 water positron emission tomography in coronary heart disease
    Wolfgang M Schaefer
    Department of Nuclear Medicine, University Hospital, Aachen, Germany
    Am J Cardiol 91:469-72. 2003
  65. ncbi Repeatability of cold pressor test-induced flow increase assessed with H(2)(15)O and PET
    Patrick T Siegrist
    Nuclear Cardiology, Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland
    J Nucl Med 47:1420-6. 2006
    ..The aim of this study was to evaluate the repeatability of endothelium-related myocardial blood flow (MBF) responses to cold pressor testing (CPT) as assessed by PET...
  66. ncbi Proposal of blood volume-corrected model for quantification of regional cerebral blood flow with H2 15O-PET and its application to AVF
    Chie Seki
    Department of Radiology, Faculty of Medicine, The University of Tokyo, 3 7 1 Hongo, Tokyo, Japan
    Radiat Med 24:260-8. 2006
    ..We attempted to surpass the assumption of abnormal vascular conditions where the vascular tracer activity is significant by introducing the vascular component into the model...
  67. ncbi Multitracer study with positron emission tomography in Creutzfeldt-Jakob disease
    Henry Engler
    Department of Neurology, Uppsala University Hospital, Uppsala, Sweden
    Eur J Nucl Med Mol Imaging 30:85-95. 2003
    ..In conclusion, the PET findings obtained using DED and FDG paralleled neuropathological findings indicating neuronal dysfunction and astrocytosis, changes that are found in CJD...
  68. ncbi Imaging of cerebral blood flow and metabolism
    Jonathan P Coles
    University Department of Anaesthesia, Addenbrooke s Hospital, Cambridge, UK
    Curr Opin Anaesthesiol 19:473-80. 2006
    ..To review the techniques for imaging cerebral blood flow and metabolism following injury to the brain...
  69. ncbi Cortical processing of noxious somatosensory stimuli in the persistent vegetative state
    S Laureys
    Cyclotron Research Center, University of Liège B30, Department of Neurology, CHU B35, Sart Tilman, 4000 Liege, Belgium
    Neuroimage 17:732-41. 2002
    ..However, this activation of primary cortex seems to be isolated and dissociated from higher-order associative cortices...
  70. ncbi Evaluation of a commercial PET tomograph-based system for the quantitative assessment of rCBF, rOEF and rCMRO2 by using sequential administration of 15O-labeled compounds
    Miho Shidahara
    Department of Investigative Radiology, National Cardio Vascular Center, Research Institute, Suita, Osaka, Japan
    Ann Nucl Med 16:317-27. 2002
    ..This suggested the need for a dynamic acquisition of a sinogram with a short interval. The proposed strategy provided an accurate quantification of CBF and OEF by PET with 15O-tracers...
  71. ncbi Topography of cortical activation differs for fundamental and harmonic frequencies of the steady-state visual-evoked responses. An EEG and PET H215O study
    M A Pastor
    Department of the Neurological Sciences, Center for Applied Medical Research, University of Navarra School of Medicine and the Clínica Universitaria de Navarra, Pamplona, Spain
    Cereb Cortex 17:1899-905. 2007
    ..Our finding suggests that the inferior portion of the banks of the parieto-occipital sulci contains association visual cortex involved in the processing of stimuli that can be as simple as a flickering light source...
  72. ncbi Functional abnormalities in the neural circuitry of reading in men with nonsyndromic clefts of the lip or palate
    Grant Goldsberry
    Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Cleft Palate Craniofac J 43:683-90. 2006
    ..By using radioactively labeled water (O(15)), regional brain blood flow was obtained during the performance of three simple reading tasks: reading unrelated words, reading unrelated sentences, and reading a story...
  73. pmc Transitions between dynamical states of differing stability in the human brain
    Andreas Meyer-Lindenberg
    Clinical Brain Disorders Branch, National Institute of Mental Health, and Human Cortical Physiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:10948-53. 2002
    ....
  74. ncbi PET tracer technology for monitoring focal epilepsies
    Matthias J Koepp
    National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Expert Rev Med Devices 4:191-200. 2007
    ....
  75. doi Regional cerebral blood flow and glucose metabolism during propofol anaesthesia in healthy subjects studied with positron emission tomography
    L Schlünzen
    Department of Neuroanaesthesiology, Aarhus University Hospitals, Denmark
    Acta Anaesthesiol Scand 56:248-55. 2012
    ..With the present study, we wanted to assess quantitatively the effects of propofol on rCBF and rGMR in the same healthy volunteers measured with positron emission tomography (PET)...
  76. doi Renal cortical and medullary blood flow during modest saline loading in humans
    M Damkjær
    Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
    Acta Physiol (Oxf) 205:472-83. 2012
    ..Studies in anaesthetized animals generally support the concept in contrast to measurements in conscious animals. We hypothesized that saline-induced natriuresis is associated with changes in RMBF in humans...
  77. doi A universal and multiplex kinase assay using γ-[(18)O(4)]-ATP
    Chuan Fu
    Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, PR China
    Chem Commun (Camb) 49:2795-7. 2013
    ..Using this approach, the effectiveness and specificity of inhibitors on several kinases could be readily determined...
  78. ncbi Long-term consequences of switching handedness: a positron emission tomography study on handwriting in "converted" left-handers
    Hartwig R Siebner
    Sobell Department of Neurophysiology, Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 22:2816-25. 2002
    ....
  79. ncbi Electrical admittance for filling of the heart during lower body negative pressure in humans
    Y Cai
    Department of Anesthesia, Rigshospitalet, DK 2100 Copenhagen, Denmark
    J Appl Physiol (1985) 89:1569-76. 2000
    ..84 (P < 0.05). The results suggest that thoracic electrical admittance of intracellular water can be applied to evaluate changes in blood volume of the heart during LBNP in humans...
  80. ncbi Changes in regional cerebral blood flow elicited by craving memories in abstinent opiate-dependent subjects
    M R Daglish
    Psychopharmacology Unit, School of Medical Sciences, University of Bristol, Bristol, UK
    Am J Psychiatry 158:1680-6. 2001
    ..CONCLUSIONS: The patterns of cerebral activation reflect the different brain regions mediating the salience of opiate-related stimuli and the subjective experience of craving for opiates...
  81. ncbi Precise localization of dysfunctional areas in vertebro-basilar infarction by FDG- and O-15-H2O-PET using standardized image analysis and image registration to 3-D MR
    F D Juengling
    Department of Radiology, University Hospital Freiburg, Germany
    Nuklearmedizin 38:341-4. 1999
    ....
  82. ncbi [The regional cerebral blood flow pattern of the normal human brain and its factorial structure]
    G V Kataeva
    Fiziol Cheloveka 33:5-10. 2007
  83. pmc External globus pallidus stimulation modulates brain connectivity in Huntington's disease
    Noémie Ligot
    Laboratoire de Cartographie Fonctionnelle du Cerveau, ULB Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    J Cereb Blood Flow Metab 31:41-6. 2011
    ..These data indicate that GPe stimulation modulates functional integration in HD patients in accordance with the basal ganglia-thalamocortical circuit model...
  84. ncbi Prefrontal contributions to delayed spatial and object alternation: a positron emission tomography study
    David H Zald
    Department of Psychology, Vanderbilt University, USA
    Neuropsychology 16:182-9. 2002
    ..Additional activations localized to several nonfrontal regions suggest caution in interpreting alternation deficits in patients as strictly reflecting frontal lobe impairment...
  85. ncbi Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy
    Tomas Furmark
    Department of Psychology, Uppsala University, Box 1225, SE 751 42 Uppsala, Sweden
    Arch Gen Psychiatry 59:425-33. 2002
    ..Neurofunctional changes underlying effective antianxiety treatments are incompletely characterized. This study explored the effects of citalopram and cognitive-behavioral therapy on regional cerebral blood flow (rCBF) in social phobia...
  86. ncbi Brain activation during human male ejaculation revisited
    Janniko R Georgiadis
    Department of Anatomy and Embryology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Neuroreport 18:553-7. 2007
    ..This revision offers a new and more accurate insight into the brain regions involved in human male ejaculation...
  87. ncbi [Effect of flumazenil on the regional cerebral blood flow measured by [15O]-butanol PET scan and transcranial Doppler ultrasonography]
    Csaba Munkácsy
    Debreceni Egyetem, Orvos és Egészségtudományi Centrum, Neurológiai Klinika, Debrecen
    Orv Hetil 143:1327-30. 2002
    ..001) in the intact brain tissue on the other side. The TCD measurements showed no significant differences between the blood flow in the MCAs supplying the affected and the contralateral lobe...
  88. ncbi Mechanism of the oxidation of sulfides by dioxiranes. 1. Intermediacy of a 10-S-4 hypervalent sulfur adduct
    María Elena González-Núñez
    Departamento de Quimica Organica, Universidad de Valencia, Avda V Andres Estelles s n, 46100 Burjassot, Valencia, Spain
    J Am Chem Soc 124:9154-63. 2002
    ....
  89. doi Stroke volume measurements with first-pass dynamic positron emission tomography: comparison with cardiovascular magnetic resonance
    Paul Knaapen
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Cardiol 15:218-24. 2008
    ..The aim of this study was to compare first-pass derived SV with cardiovascular magnetic resonance imaging (CMR)-obtained values in a larger population of subjects...
  90. pmc Theory of mind and schizophrenia: a positron emission tomography study of medication-free patients
    Nancy C Andreasen
    Department of Psychiatry, The University of Iowa Carver College of Medicine, 200 Hawkins Drive, Room W278GH, Iowa City, IA 52242 1057, USA
    Schizophr Bull 34:708-19. 2008
    ..This capacity, critical for social competence, is impaired in schizophrenia. We undertook a study of TOM in a group of patients with schizophrenia and healthy controls...
  91. doi Photophobia in migraine: an interictal PET study of cortical hyperexcitability and its modulation by pain
    Nicolas Boulloche
    Service de Neurologie et Explorations Fonctionnelles du Système Nerveux, CHU Rangueil, 31059 Toulouse Cedex 9, France
    J Neurol Neurosurg Psychiatry 81:978-84. 2010
    ..In clinical studies, an inter-relation between light perception and trigeminal nociception has been demonstrated in migraineurs but not in controls. The purpose of the study was to verify this interaction by functional imaging...
  92. doi Vasodilatory effect of adenosine triphosphate does not change cerebral blood flow: a PET study with (15)O-water
    Raihan Hussain
    Biomedical Imaging Research Center BIRC, University of Fukui, 23 3 Shimoaizuki, Matsuoka, Eiheiji cho, Fukui, 910 1193, Japan
    Ann Nucl Med 23:717-23. 2009
    ..To investigate the effect of ATP on cerebral blood flow (CBF) and cerebral vessels, (15)O-water positron emission tomography (PET) studies were performed to evaluate changes in CBF and blood volume before and after ATP administration...
  93. ncbi Optimization of the injected activity in dynamic 3D PET: a generalized approach using patient-specific NECs as demonstrated by a series of 15O-H2O scans
    Matthew D Walker
    School of Cancer and Imaging Sciences, Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom
    J Nucl Med 50:1409-17. 2009
    ..The magnitude of the injected activity (A(0)) has a direct impact on the statistical quality of PET images. This study aimed to develop a generalized method for maximizing the statistical quality of dynamic PET images by optimizing A(0)...
  94. ncbi Patterns of regional brain activation associated with different forms of motor learning
    M Ghilardi
    Center for Neurobiology and Behavior, Center for Neurobiology and Behavior, NYS Psychiatric Institute, Columbia College of Physicians and Surgeons, PI Annex Room 819, 10032, New York, NY, USA
    Brain Res 871:127-45. 2000
    ..These tasks can be used to assess specific aspects of motor learning with imaging in health and disease...
  95. ncbi Interdependence of regional and global cerebral blood flow during visual stimulation: an O-15-butanol positron emission tomography study
    L J Kemna
    , , Germany
    J Cereb Blood Flow Metab 21:664-70. 2001
    ..At low PETCO2, the activation-induced flow changes are moderately damped, whereas at high PETCO2, they are nearly lost (deltaCBF (+/-SD): 52% +/- 25%, 68% +/- 22%, 16% +/- 25% at PETCO2 = 20, 40, 70 mm Hg, respectively)...
  96. ncbi Cerebral blood flow changes induced by pedunculopontine nucleus stimulation in patients with advanced Parkinson's disease: a [(15)O] H2O PET study
    Benedicte Ballanger
    Toronto Western Research Institute Division of Brain, Imaging and Behaviour Systems Neuroscience, UHN, University of Toronto, Toronto, Ontario, Canada
    Hum Brain Mapp 30:3901-9. 2009
    ..Whether these findings are associated with the DBS-PPN clinical effect remains to be proven. However, they suggest that PPN modulation may induce functional changes in neural networks associated with the control of lower limb movements...
  97. ncbi In vivo measurement of cerebral blood flow: a review of methods and applications
    P D Griffiths
    Section of Academic Radiology, University of Sheffield, UK
    Vasc Med 6:51-60. 2001
    ..Applications of magnetic resonance and X-ray computed tomographic methods are reviewed and illustrated by examples from the authors' radiological practice...
  98. doi Evaluation of coronary endothelial dysfunction in healthy young smokers: Cold pressor test using [(15)O]H(2)O PET
    Kyung Hoon Hwang
    Department of Nuclear Medicine, The Gachon University Gil Hospital of Korea, 1198, Guwol dong, Namdong gu, Incheon 405 760, Republic of Korea
    Appl Radiat Isot 67:1199-203. 2009
    ..81+/-1.99 vs. 5.03+/-1.27ml/g/min; P=NS). This study shows that [(15)O]H(2)O PET analysis can reveal that endothelial dysfunction occurs in even young smokers of about 6 pack years...
  99. doi Parametric renal blood flow imaging using [15O]H2O and PET
    Nobuyuki Kudomi
    Turku PET Centre, University of Turku, Turku, Finland
    Eur J Nucl Med Mol Imaging 36:683-91. 2009
    ..ml/ml) to be negligible. The aim of this study was to develop a method for calculating parametric images of RBF (K(1), k(2)) as well as V(A) without fixing the partition coefficient by the basis function method (BFM)...
  100. ncbi Blind separation of cardiac components and extraction of input function from H(2)(15)O dynamic myocardial PET using independent component analysis
    J S Lee
    Department of Nuclear Medicine Seoul National University College of Medicine, Seoul, Korea
    J Nucl Med 42:938-43. 2001
    ..45 + 0.98x; r = 0.95, P < 0.000). CONCLUSION: ICA, a rapid and reliable method for extraction of the pure physiologic components, was a valid and useful method for quantification of the regional MBF using H(2)(15)O PET...
  101. ncbi Enhanced stimulation of glucose uptake by insulin increases exercise-stimulated glucose uptake in skeletal muscle in humans: studies using [15O]O2, [15O]H2O, [18F]fluoro-deoxy-glucose, and positron emission tomography
    P Nuutila
    Department of Medicine, University of Turku, Finland
    Diabetes 49:1084-91. 2000
    ..05). We conclude that whereas acute exercise per se increases glucose uptake via increasing glucose delivery, good insulin sensitivity modulates exercise-induced increases in glucose uptake by enhancing cellular glucose extraction...

Research Grants95

  1. An fMRI Study of the Impact of Stress on Drug Addiction
    Clinton D Kilts; Fiscal Year: 2010
    ....
  2. IMAGING THE RESPONSE OF LOCALLY ADVANCED BREAST CANCER
    David Mankoff; Fiscal Year: 1999
    ....
  3. PET to Measure Breast Cancer Bone Metastasis Response
    David A Mankoff; Fiscal Year: 2010
    ....
  4. Diagnosis of IM Nodal Metastases in Breast Cancer
    David Mankoff; Fiscal Year: 2002
    ..This diagnostic study will provide important data to direct future internal mammary radiotherapy trials. ..
  5. IMAGING THE RESPONSE OF LOCALLY ADVANCED BREAST CANCER
    David Mankoff; Fiscal Year: 2005
    ..In this amended application, we focus on recent progress that has strengthened our preliminary data and further supports our proposed investigations of the biology of advanced breast cancer and its relationship to therapeutic response. ..
  6. Diagnosis of IM Nodal Metastases in Breast Cancer
    David Mankoff; Fiscal Year: 2003
    ..This diagnostic study will provide important data to direct future internal mammary radiotherapy trials. ..
  7. PET to Measure Breast Cancer Bone Metastasis Response
    David Mankoff; Fiscal Year: 2009
    ....
  8. PET to Measure Breast Cancer Bone Metastasis Response
    David Mankoff; Fiscal Year: 2007
    ....
  9. IMAGING THE RESPONSE OF LOCALLY ADVANCED BREAST CANCER
    David Mankoff; Fiscal Year: 2003
    ..In this amended application, we focus on recent progress that has strengthened our preliminary data and further supports our proposed investigations of the biology of advanced breast cancer and its relationship to therapeutic response. ..
  10. IMAGING THE RESPONSE OF LOCALLY ADVANCED BREAST CANCER
    David Mankoff; Fiscal Year: 2004
    ..In this amended application, we focus on recent progress that has strengthened our preliminary data and further supports our proposed investigations of the biology of advanced breast cancer and its relationship to therapeutic response. ..
  11. Diagnosis of IM Nodal Metastases in Breast Cancer
    David Mankoff; Fiscal Year: 2004
    ..This diagnostic study will provide important data to direct future internal mammary radiotherapy trials. ..
  12. IMAGING THE RESPONSE OF LOCALLY ADVANCED BREAST CANCER
    David Mankoff; Fiscal Year: 2006
    ..In this amended application, we focus on recent progress that has strengthened our preliminary data and further supports our proposed investigations of the biology of advanced breast cancer and its relationship to therapeutic response. ..
  13. PET to Measure Breast Cancer Bone Metastasis Response
    David Mankoff; Fiscal Year: 2008
    ....
  14. IMAGING THE RESPONSE OF LOCALLY ADVANCED BREAST CANCER
    David Mankoff; Fiscal Year: 2002
    ..In this amended application, we focus on recent progress that has strengthened our preliminary data and further supports our proposed investigations of the biology of advanced breast cancer and its relationship to therapeutic response. ..
  15. Diagnosis of IM Nodal Metastases in Breast Cancer
    David Mankoff; Fiscal Year: 2001
    ..This diagnostic study will provide important data to direct future internal mammary radiotherapy trials. ..
  16. IMAGING THE RESPONSE OF LOCALLY ADVANCED BREAST CANCER
    David Mankoff; Fiscal Year: 2000
    ....
  17. ONTOGENY OF GABAA RECEPTOR COMPLEX MEASURED WITH PET
    Otto Muzik; Fiscal Year: 2001
    ..abstract_text> ..
  18. Neuroscience Studies on Early Detection of Schizophrenia
    Beng Choon Ho; Fiscal Year: 2008
    ..Taken together, the training program and research plan provide the potential for scientific discovery as well as support for the establishment of an independent research career. ..
  19. Cocaine Dependence and Cognitive Control of Behavior
    Clinton Kilts; Fiscal Year: 2006
    ..The long-term goal of these studies is to develop a novel understanding of the processes related to the acquisition, maintenance and social consequences of cocaine addiction. [unreadable] [unreadable]..
  20. Motor learning and memory in health and disease
    Reza Shadmehr; Fiscal Year: 2010
    ....
  21. Motor learning and memory in health and disease
    Reza Shadmehr; Fiscal Year: 2003
    ..We ask how this change affects the generalization function. Is the brain different in the way it responds to an error after a memory has consolidated vs. early in the learning phase? ..
  22. "CRCNS: A Bayesian Framework for Sensorimotor Learning and Control"
    Reza Shadmehr; Fiscal Year: 2006
    ..Development of this new theoretical framework will ultimately shed light on the computations that are performed by structures in the brain that participate in control of our movements. ..
  23. Neurochemistry of Opiate Abuse Risk in Chronic Pain
    Jon Kar Zubieta; Fiscal Year: 2006
    ..g., pain variability, distress in responses to variations in pain, impulsive choice and rewarding responses to acute opiate administration). ..
  24. REGIONAL LUNG FUNCTION IN ACUTE LUNG INJURY
    Guido Musch; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable]..
  25. Predicting Placebo Responses Across Disease States
    Jon Kar Zubieta; Fiscal Year: 2010
    ..The proposed studies benefit from unique features of the scientific environment, subject populations, or employ useful collaborative arrangements. There is evidence of institutional support. ..
  26. The Amygdala: Emotional Modulation of Attention
    David Zald; Fiscal Year: 2009
    ..Thus, the study will be able to address the effects of amygdala lesions with a degree of precision that has been unattainable in previous research on the human amygdala. ..
  27. Treatment of Hypochondriasis with CBT &/or SSRI
    Brian Fallon; Fiscal Year: 2008
    ..Most recently, the 2004 National Advisory Mental Health Council's Workgroup on Clinical Trials stated: "the portfolio must include more research in this area"...
  28. BIOMEDICAL ENGINEERING TRAINING PROGRAM
    Reza Shadmehr; Fiscal Year: 2007
    ..Program coursework includes graduate level courses in life sciences plus advanced courses in engineering, mathematics, and biology. The core of the program is research training in the research laboratories of the Program faculty. ..
  29. PET Evalutaion of Hemorrhagic Shock and Resuscitation
    Vibhudutta Awasthi; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  30. Individual Differences in Extrastriatal DA Release
    David Zald; Fiscal Year: 2008
    ..abstract_text> ..
  31. Research Training in Nuclear Molecular Imaging
    Alan Fischman; Fiscal Year: 2007
    ..abstract_text> ..
  32. Neurochemistry of Opiate Abuse Risk in Chronic Pain
    Jon Kar Zubieta; Fiscal Year: 2007
    ..g., pain variability, distress in responses to variations in pain, impulsive choice and rewarding responses to acute opiate administration). ..
  33. Graduate Training in Psychology and Neuroimaging
    Stephen Kosslyn; Fiscal Year: 2007
    ..Throughout their training, students will be co-advised by one Harvard Psychology and one Martinos Center faculty. ..
  34. PET Evaluation of Hemorrhagic Shock and Resuscitation
    Vibhudutta Awasthi; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  35. Neuropharmacology of Cocaine in Nonhuman Primates
    Leonard Howell; Fiscal Year: 2008
    ....
  36. Quantitative and Non-invasive Imaging of Oxygen Metabolism in Human Brain
    Xiao Hong Zhu; Fiscal Year: 2010
    ..It will also provide a great opportunity for moving forward the translational medical research, ultimately, leading to a clinical imaging tool for diagnosis of brain diseases. ..
  37. Quantitative and Non-invasive Imaging of Oxygen Metabolism in Human Brain
    Xiao Hong Zhu; Fiscal Year: 2010
    ..It will also provide a great opportunity for moving forward the translational medical research, ultimately, leading to a clinical imaging tool for diagnosis of brain diseases. ..
  38. Neural Circuits in Women with Abuse and PTSD
    JAMES DOUGLAS BREMNER; Fiscal Year: 2010
    ..We hypothesize that paroxetine will result in an improvement in memory function, increased hippocampal volume and NAA, and increased frontal and hippocampal function ..
  39. The Amygdala: Emotional Modulation of Attention
    David H Zald; Fiscal Year: 2010
    ..Thus, the study will be able to address the effects of amygdala lesions with a degree of precision that has been unattainable in previous research on the human amygdala. ..
  40. Predicting Placebo Responses Across Disease States
    Jon Kar Zubieta; Fiscal Year: 2009
    ..The proposed studies benefit from unique features of the scientific environment, subject populations, or employ useful collaborative arrangements. There is evidence of institutional support. ..
  41. Treatment of Hypochondriasis with CBT &/or SSRI
    Brian Fallon; Fiscal Year: 2009
    ..Most recently, the 2004 National Advisory Mental Health Council's Workgroup on Clinical Trials stated: "the portfolio must include more research in this area"...
  42. Effect of Prone Position on Ventilator-Induced Lung Injury
    Guido Musch; Fiscal Year: 2010
    ..In this research, we will test whether promoting uniform lung inflation and tidal expansion by prone positioning reduces neutrophil metabolic activation, an early and important event in the pathogenesis of VILI. ..
  43. Individual Differences in Extrastriatal DA Release
    David Zald; Fiscal Year: 2009
    ..abstract_text> ..
  44. "CRCNS: A Bayesian Framework for Sensorimotor Learning and Control"
    Reza Shadmehr; Fiscal Year: 2008
    ..Development of this new theoretical framework will ultimately shed light on the computations that are performed by structures in the brain that participate in control of our movements. ..
  45. AN FMRI STUDY OF RELATIVE REWARD PROCESSING IN ADOLESCENTS AND ADULTS
    Jatin Vaidya; Fiscal Year: 2008
    ..Based on this research, it will be possible to develop prevention and treatment programs that take into consideration motivational processes that may be unique to adolescents. [unreadable] [unreadable] [unreadable]..
  46. Event-related neuroimaging of human memory formation
    DANIEL SCHACTER; Fiscal Year: 2008
    ..The proposed studies will increase our understanding of how memories are constructed, and will also contribute to efforts to improve memory. ..
  47. Interaction of Smoking and Chronic Pain at Neurochemical and Phenotypic Levels
    Jon Kar Zubieta; Fiscal Year: 2010
    ..Neural responses will then be related to the individual pain report and severity of nicotine addiction. ..
  48. Neuropharmacology of Cocaine in Nonhuman Primates
    Leonard Howell; Fiscal Year: 2007
    ....
  49. The Long Island Parkinson's Disease Center
    Andrew Feigin; Fiscal Year: 2003
    ..abstract_text> ..
  50. Motor learning and memory in health and disease
    Reza Shadmehr; Fiscal Year: 2006
    ..We ask how this change affects the generalization function. Is the brain different in the way it responds to an error after a memory has consolidated vs. early in the learning phase? [unreadable] [unreadable]..
  51. Treatment of Hypochondriasis with CBT &/or SSRI
    Brian Fallon; Fiscal Year: 2006
    ..Most recently, the 2004 National Advisory Mental Health Council's Workgroup on Clinical Trials stated: "the portfolio must include more research in this area"...
  52. PET AND MRI IMAGING OF PERSISTENT LYME ENCEPHALOPATHY
    Brian Fallon; Fiscal Year: 2003
    ..This study will enhance our understanding of the pathophysiology and treatment of patients suffering with the disabling effects of persistent Lyme encephalopathy. ..
  53. Motor learning and memory in health and disease
    Reza Shadmehr; Fiscal Year: 2004
    ..We ask how this change affects the generalization function. Is the brain different in the way it responds to an error after a memory has consolidated vs. early in the learning phase? ..
  54. BRAIN BLOOD FLOW IMAGING OF COCAINE WITHDRAWAL & CRAVING
    ANNA CHILDRESS; Fiscal Year: 2002
    ..Intentionally, we use manipulations with direct clinical relevance. The revealed substrates may well be relevant for other substance, and non-substance, addictions. ..
  55. BEHAVIORAL GENETICS--MODELS/MECHANISMS OF SCHIZOPHRENIA
    Clinton Kilts; Fiscal Year: 2002
    ..abstract_text> ..
  56. IMAGING MARKERS FOR ASSESSING PROGRESSION IN MOVEMENT
    Andrew Feigin; Fiscal Year: 2003
    ..The extension of this career development award will allow the candidate to become a fully independent and productive clinical scientist. ..
  57. An fMRI Study of the Impact of Stress on Drug Addiction
    Clinton Kilts; Fiscal Year: 2007
    ....
  58. HIPPOCAMPUS IN WOMEN WITH CHILDHOOD ABUSE RELATED PTSD
    JAMES BREMNER; Fiscal Year: 2000
    ..We hypothesize a relationship between a failure in hippocampal activation and hippocampal volume reduction in patients with PTSD. ..
  59. Cognitive Enhancers Explored with PET Imaging
    Susan Schultz; Fiscal Year: 2003
    ....
  60. Event-related neuroimaging of human memory formation
    DANIEL SCHACTER; Fiscal Year: 2009
    ..The proposed studies will increase our understanding of how memories are constructed, and will also contribute to efforts to improve memory. ..
  61. Mechanisms of Depression in CVD
    JAMES BREMNER; Fiscal Year: 2008
    ..Understanding brain-based mechanisms by which depression increases mortality from CVD has the potential to lead to new treatments for this disorder. ..
  62. Extinction of Limbic Activation to "Unseen" Cocaine Cues
    ANNA CHILDRESS; Fiscal Year: 2009
    ..The current project tests whether extinction of the brain response to cocaine cues can occur outside awareness, and whether extinction can be facilitated by the partial agonist varenicline. ..
  63. Elderly Cancer Survivors: Cognitive Outcomes and Markers of Neurodegeneration
    Susan Schultz; Fiscal Year: 2009
    ..By exploring the underlying mechanisms for neurodegeneration, specific testable treatments and prevention strategies may ultimately be developed. ..
  64. Brain Blood Flow Imaging of Cocaine Withdrawal&Craving
    ANNA CHILDRESS; Fiscal Year: 2004
    ..Intentionally, we use manipulations with direct clinical relevance. The revealed substrates may well be relevant for other substance, and non-substance, addictions. ..
  65. Cognition-Emotion-HPA Interaction: Translation Network
    Israel Liberzon; Fiscal Year: 2007
    ..It will provide a foundation for larger translational science projects and a context for training the translational scientists of the future. [unreadable] [unreadable]..
  66. Event-related neuroimaging of human memory formation
    DANIEL SCHACTER; Fiscal Year: 2005
    ..The proposed studies will increase our understanding of how memories are constructed, and will also contribute to efforts to improve memory. ..
  67. Consolidation of Motor Skills & Sleep Homeostasis in Parkinson's Disease
    M Ghilardi; Fiscal Year: 2007
    ..Consistent with the goals of NINDS, these studies will provide the basis for a rational therapeutic approach to enhancing sleep homeostasis in PD patients to improve their motor skills and quality of life. ..
  68. Cocaine Dependence and Cognitive Control of Behavior
    Clinton Kilts; Fiscal Year: 2005
    ..The long-term goal of these studies is to develop a novel understanding of the processes related to the acquisition, maintenance and social consequences of cocaine addiction. ..
  69. STAGES OF MOTOR SKILL CONSOLIDATION IN THE HUMAN BRAIN
    Reza Shadmehr; Fiscal Year: 2002
    ..With a better understanding of how the normal brain learns a new motor skills and how time influences its representation, we will better understand motor learning and rehabilitation processes in the damaged brain. ..
  70. EVENT RELATED NEUROIMAGING OF HUMAN MEMORY FORMATION
    DANIEL SCHACTER; Fiscal Year: 2002
    ..The proposed studies will provide new information about the neuroanatomical bases of encoding processes and thereby contribute to the further development of rehabilitation efforts. ..
  71. GABA B AGONISTS IN HUMAN COCAINE DEPENDENCE
    ANNA CHILDRESS; Fiscal Year: 2002
    ..Dependent variables in Study 2 will include drug use as measured by frequent urine toxicologies, ambient and cue-elicited craving. treatment retention, and standard measures of clinical function. ..
  72. Individual Differences in Extrastriatal DA Release
    David Zald; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  73. Treatment of Hypochondriasis with CBT &/or SSRI
    Brian Fallon; Fiscal Year: 2007
    ..Most recently, the 2004 National Advisory Mental Health Council's Workgroup on Clinical Trials stated: "the portfolio must include more research in this area"...
  74. HIPPOCAMPUS IN WOMEN WITH CHILDHOOD ABUSE RELATED PTSD
    JAMES BREMNER; Fiscal Year: 2001
    ..We hypothesize a relationship between a failure in hippocampal activation and hippocampal volume reduction in patients with PTSD. ..
  75. Training Program in Neuroimaging Sciences
    JAMES BREMNER; Fiscal Year: 2007
    ..Clinical research training is offered in imaging techniques (PET, MRI, fMRI, spectroscopy) with applications to mental health. ..
  76. Neurochemical Endophenotype Responses to Pain-Stress
    Jon Kar Zubieta; Fiscal Year: 2007
    ....
  77. Motor Learning in Parkinson's Disease
    M Ghilardi; Fiscal Year: 2002
    ....
  78. Motor learning and memory in health and disease
    Reza Shadmehr; Fiscal Year: 2009
    ....
  79. Motor learning and memory in health and disease
    Reza Shadmehr; Fiscal Year: 2007
    ..abstract_text> ..
  80. Motor learning and memory in health and disease
    Reza Shadmehr; Fiscal Year: 2005
    ..We ask how this change affects the generalization function. Is the brain different in the way it responds to an error after a memory has consolidated vs. early in the learning phase? ..
  81. Neural Circuits in Women with Abuse and PTSD
    JAMES BREMNER; Fiscal Year: 2007
    ..We hypothesize that paroxetine will result in an improvement in memory function, increased hippocampal volume and NAA, and increased frontal and hippocampal function ..
  82. Neurochemical Endophenotype Responses to Pain-Stress
    Jon Kar Zubieta; Fiscal Year: 2006
    ....
  83. An fMRI Study of the Impact of Stress on Drug Addiction
    Clinton Kilts; Fiscal Year: 2009
    ....
  84. Neurochemical Endophenotype Responses to Pain-Stress
    Jon Kar Zubieta; Fiscal Year: 2004
    ....
  85. Event-related neuroimaging of human memory formation
    DANIEL SCHACTER; Fiscal Year: 2006
    ..The proposed studies will increase our understanding of how memories are constructed, and will also contribute to efforts to improve memory. ..
  86. Mental Health Research Education Grant (R25)
    Israel Liberzon; Fiscal Year: 2007
    ..This program strives to foster the development of mental health researchers by providing the training, structure, and resources that are necessary to begin an academic, research-focused career in psychiatry. ..
  87. Neural Circuits in Women with Abuse and PTSD
    JAMES BREMNER; Fiscal Year: 2009
    ..We hypothesize that paroxetine will result in an improvement in memory function, increased hippocampal volume and NAA, and increased frontal and hippocampal function ..
  88. STAGES OF MOTOR SKILL CONSOLIDATION IN THE HUMAN BRAIN
    Reza Shadmehr; Fiscal Year: 2001
    ..With a better understanding of how the normal brain learns a new motor skills and how time influences its representation, we will better understand motor learning and rehabilitation processes in the damaged brain. ..
  89. Neural Circuits in Women with Abuse and PTSD
    JAMES BREMNER; Fiscal Year: 2004
    ..We hypothesize increased SC responses will correlate with increased amygdala/decreased prefrontal function in PTSD. Secondary exploratory analyses will compare brain activation patterns in early onset to adult onset PTSD. ..