ferric compounds

Summary

Summary: Inorganic or organic compounds containing trivalent iron.

Top Publications

  1. ncbi Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
    Ajay Kumar Gupta
    Crusade Laboratories Limited, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, Scotland, UK
    Biomaterials 26:3995-4021. 2005
  2. ncbi Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging
    Y X Wang
    Department of Radiology, Erasmus University Medical Center-Dijkzigt, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Eur Radiol 11:2319-31. 2001
  3. pmc SreA-mediated iron regulation in Aspergillus fumigatus
    Markus Schrettl
    Divisions of Molecular Biology Biocenter, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Mol Microbiol 70:27-43. 2008
  4. ncbi Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging
    Jae Hyun Lee
    Department of Chemistry and Nanomedical National Core Research Center, Yonsei University, Seoul 120 749, Korea
    Nat Med 13:95-9. 2007
  5. ncbi Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy
    I Jolanda M de Vries
    Department of Tumor Immunology, Radboud University Nijmegen Medical Center and Nijmegen Center for Molecular Life Sciences, Geert Grooteplein 28, 6500 HB Nijmegen, The Netherlands
    Nat Biotechnol 23:1407-13. 2005
  6. ncbi Recent advances in iron oxide nanocrystal technology for medical imaging
    Claire Corot
    Guerbet Research, BP 57400, 95943 Roissy CDG, France
    Adv Drug Deliv Rev 58:1471-504. 2006
  7. pmc In vivo MRI cell tracking: clinical studies
    Jeff W M Bulte
    Russell H Morgan Department of Radiology, Division of MR Research, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    AJR Am J Roentgenol 193:314-25. 2009
  8. doi Ferric carboxymaltose in patients with heart failure and iron deficiency
    Stefan D Anker
    Department of Cardiology, Campus Virchow Klinikum, Charite Universitatsmedizin, Berlin
    N Engl J Med 361:2436-48. 2009
  9. ncbi Intracellular uptake of anionic superparamagnetic nanoparticles as a function of their surface coating
    C Wilhelm
    Laboratoire des Milieux Désordonnés et Hétérogènes UMR7603, Universite Pierre et Marie Curie, Tour 13, Case 86, 4 place Jussieu, 75005 Paris, France
    Biomaterials 24:1001-11. 2003
  10. pmc Size, charge and concentration dependent uptake of iron oxide particles by non-phagocytic cells
    Daniel L J Thorek
    Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, PA 19104, USA
    Biomaterials 29:3583-90. 2008

Research Grants

  1. Biomimetic Studies of NO-binding Respiratory Chain Hemes
    JAMES COLLMAN; Fiscal Year: 2007
  2. Quantitative Subharmonic Breast Imaging
    Flemming Forsberg; Fiscal Year: 2010
  3. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2007
  4. Pathobiology of Kidney Disease: Role of Iron
    Rajiv Agarwal; Fiscal Year: 2008
  5. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2005
  6. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2004
  7. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2006
  8. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2003
  9. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2010
  10. DETERMINING THE GENETICS OF RESTLESS LEGS SYNDROME
    Christopher Earley; Fiscal Year: 2002

Detail Information

Publications280 found, 100 shown here

  1. ncbi Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
    Ajay Kumar Gupta
    Crusade Laboratories Limited, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, Scotland, UK
    Biomaterials 26:3995-4021. 2005
    ..This review discusses the synthetic chemistry, fluid stabilization and surface modification of superparamagnetic iron oxide nanoparticles, as well as their use for above biomedical applications...
  2. ncbi Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging
    Y X Wang
    Department of Radiology, Erasmus University Medical Center-Dijkzigt, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Eur Radiol 11:2319-31. 2001
    ..Iron oxide particles for bowel contrast are coated with insoluble material, and all iron oxide particles for intravenous injection are biodegradable. Superparamagnetic agents open up an important field for research in MR imaging...
  3. pmc SreA-mediated iron regulation in Aspergillus fumigatus
    Markus Schrettl
    Divisions of Molecular Biology Biocenter, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Mol Microbiol 70:27-43. 2008
    ..As all detrimental effects of sreA disruption are restricted to iron-replete conditions these data underscore that A. fumigatus faces iron-depleted conditions during infection...
  4. ncbi Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging
    Jae Hyun Lee
    Department of Chemistry and Nanomedical National Core Research Center, Yonsei University, Seoul 120 749, Korea
    Nat Med 13:95-9. 2007
    ..Also, we successfully visualized small tumors implanted in a mouse. Such high-performance, nanotechnology-based molecular probes could enhance the ability to visualize other biological events critical to diagnostics and therapeutics...
  5. ncbi Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy
    I Jolanda M de Vries
    Department of Tumor Immunology, Radboud University Nijmegen Medical Center and Nijmegen Center for Molecular Life Sciences, Geert Grooteplein 28, 6500 HB Nijmegen, The Netherlands
    Nat Biotechnol 23:1407-13. 2005
    ..MRI cell tracking using iron oxides appears clinically safe and well suited to monitor cellular therapy in humans...
  6. ncbi Recent advances in iron oxide nanocrystal technology for medical imaging
    Claire Corot
    Guerbet Research, BP 57400, 95943 Roissy CDG, France
    Adv Drug Deliv Rev 58:1471-504. 2006
    ..Stem cell migration and immune cell trafficking, as well as targeted iron oxide nanoparticles for molecular imaging studies, are at the stage of proof of concept, mainly in animal models...
  7. pmc In vivo MRI cell tracking: clinical studies
    Jeff W M Bulte
    Russell H Morgan Department of Radiology, Division of MR Research, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    AJR Am J Roentgenol 193:314-25. 2009
    ..The purpose of this review is to describe the principles of MRI cell tracking with superparamagnetic iron oxides and the four clinical trials that have been performed...
  8. doi Ferric carboxymaltose in patients with heart failure and iron deficiency
    Stefan D Anker
    Department of Cardiology, Campus Virchow Klinikum, Charite Universitatsmedizin, Berlin
    N Engl J Med 361:2436-48. 2009
    ....
  9. ncbi Intracellular uptake of anionic superparamagnetic nanoparticles as a function of their surface coating
    C Wilhelm
    Laboratoire des Milieux Désordonnés et Hétérogènes UMR7603, Universite Pierre et Marie Curie, Tour 13, Case 86, 4 place Jussieu, 75005 Paris, France
    Biomaterials 24:1001-11. 2003
    ..Kinetics of cellular particle uptake for different cell lines are quantitated using two new complementary assays (Magnetophoresis and Electron Spin Resonance)...
  10. pmc Size, charge and concentration dependent uptake of iron oxide particles by non-phagocytic cells
    Daniel L J Thorek
    Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, PA 19104, USA
    Biomaterials 29:3583-90. 2008
    ..Our results show that an unconventional highly cationic particle configuration at 107nm maximized MR contrast of T cells, outperforming the widely utilized USPIO (<50nm)...
  11. doi A novel intravenous iron formulation for treatment of anemia in inflammatory bowel disease: the ferric carboxymaltose (FERINJECT) randomized controlled trial
    Stefanie Kulnigg
    Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Am J Gastroenterol 103:1182-92. 2008
    ....
  12. ncbi Ultra-large-scale syntheses of monodisperse nanocrystals
    Jongnam Park
    National Creative Research Center for Oxide Nanocrystalline Materials and School of Chemical Engineering, Seoul National University, Seoul 151 744, Korea
    Nat Mater 3:891-5. 2004
    ..The current synthetic procedure is very general and nanocrystals of many transition metal oxides were successfully synthesized using a very similar procedure...
  13. doi Toxicity evaluations of superparamagnetic iron oxide nanoparticles: cell "vision" versus physicochemical properties of nanoparticles
    Morteza Mahmoudi
    National Cell Bank, Pasteur Institute of Iran, Tehran, 1316943551 Iran
    ACS Nano 5:7263-76. 2011
    ....
  14. ncbi Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications
    Ajay Kumar Gupta
    Laboratory for Nanoparticle Research, Formulation and Development Department, Torrent Research Centre, TPL, Village Bhat, Dist Gandhinagar 382 428, Gujarat, India
    Nanomedicine (Lond) 2:23-39. 2007
    ..We have reviewed the various biomedical applications with some of the most recent uses of magnetic nanoparticles for early detection of cancer, diabetes and atherosclerosis...
  15. pmc Stimulating the in situ activity of Geobacter species to remove uranium from the groundwater of a uranium-contaminated aquifer
    Robert T Anderson
    Department of Microbiology, University of Massachusetts, Morrill Science Center, Amherst, Massachusetts 01003, USA
    Appl Environ Microbiol 69:5884-91. 2003
    ..These results demonstrate that in situ bioremediation of uranium-contaminated groundwater is feasible but suggest that the strategy should be optimized to better maintain long-term activity of Geobacter species...
  16. ncbi In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals
    Yong Min Huh
    Yonsei Nano Medical Core Research Center, Department of Radiology, Yonsei University, Seoul 120 752, Korea
    J Am Chem Soc 127:12387-91. 2005
    ..Our study finds that high performance in vivo MR diagnosis of cancer is achievable by utilizing improved and multifunctional material properties of iron oxide nanocrystal probes...
  17. pmc Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
    Xiang Hong Peng
    Department of Medical Oncology Hematology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Int J Nanomedicine 3:311-21. 2008
    ..We review recent advances in the development of targeted IO nanoparticles for tumor imaging and therapy...
  18. doi Size-dependent toxicity of metal oxide particles--a comparison between nano- and micrometer size
    Hanna L Karlsson
    Unit for Analytical Toxicology, Department of Biosciences and Nutrition, Novum, Karolinska Insitutet, SE 141 57 Huddinge, Stockholm, Sweden
    Toxicol Lett 188:112-8. 2009
    ..In conclusion, nanoparticles are not always more toxic than micrometer particles, but the high toxicity of CuO nanoparticles shows that the nanolevel gives rise to specific concern...
  19. ncbi Iron oxide nanoparticles for sustained delivery of anticancer agents
    Tapan K Jain
    Department of Pharmaceutical Sciences, College of Pharmacy, Nebraska Medical Center, Omaha, Nebraska 68198 6025, USA
    Mol Pharm 2:194-205. 2005
    ..This nanoparticle formulation can be used as a universal drug carrier system for systemic administration of water-insoluble drugs while simultaneously allowing magnetic targeting and/or imaging...
  20. pmc Rationale and design of Ferinject assessment in patients with IRon deficiency and chronic Heart Failure (FAIR-HF) study: a randomized, placebo-controlled study of intravenous iron supplementation in patients with and without anaemia
    Stefan D Anker
    Department of Cardiology, Charite, Campus Virchow Klinikum, Augustenburger Platz 1, Berlin D 13353, Germany
    Eur J Heart Fail 11:1084-91. 2009
    ..gov NCT00520780) was designed to determine the effect of i.v. iron repletion therapy using ferric carboxymaltose on self-reported patient global assessment (PGA) and New York Heart Association (NYHA) in patients with CHF and ID...
  21. doi Assessing iron oxide nanoparticle toxicity in vitro: current status and future prospects
    Stefaan J H Soenen
    Interdisciplinary Research Centre, Laboratory of BioNanoColloids, K U Leuven Campus Kortrijk, E Sabbelaan 53, B 8500 Kortrijk, Belgium
    Nanomedicine (Lond) 5:1261-75. 2010
    ..e., cell-associated) nanoparticle levels, which could help to advance any progress in this highly important research topic...
  22. ncbi Iron-oxide labeling and outcome of transplanted mesenchymal stem cells in the infarcted myocardium
    Yoram Amsalem
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer 52621, Israel
    Circulation 116:I38-45. 2007
    ..We sought to determine whether mesenchymal stem cell (MSC) outcome is affected by SPIO labeling in a rat model of myocardial infarction...
  23. doi FERGIcor, a randomized controlled trial on ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease
    Rayko Evstatiev
    Department of Medicine 3, Division of Gastroenterology and Hepatology, Christian Doppler Laboratory for Molecular Cancer Chemoprevention, Medical University of Vienna, Vienna, Austria
    Gastroenterology 141:846-853.e1-2. 2011
    ..We compared the efficacy and safety of a novel fixed-dose ferric carboxymaltose regimen (FCM) with individually calculated iron sucrose (IS) doses in patients with inflammatory bowel disease (IBD) and IDA...
  24. doi Cytotoxic effects of iron oxide nanoparticles and implications for safety in cell labelling
    Stefaan J H Soenen
    Lab of BioNanoColloids, Interdisciplinary Research Centre, Katholieke Universiteit Leuven, Campus Kortrijk, B8500 Kortrijk, Belgium
    Biomaterials 32:195-205. 2011
    ..These results highlight the importance of in-depth cytotoxic evaluation of cell labelling studies as at non-toxic concentrations, some particles appear to be less suitable for the MR visualization of labelled cells...
  25. ncbi In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors
    Moritz F Kircher
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Cancer Res 63:6838-46. 2003
    ..Together, these results demonstrate that CLIO-HD is uniquely suited for quantitative repetitive MRI of adoptively transferred cells and that this approach may be particularly useful for evaluating novel cell-based therapies in vivo...
  26. doi Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial
    Darlington O Okonko
    Clinical Cardiology, NHLI, Imperial College London, London, United Kingdom
    J Am Coll Cardiol 51:103-12. 2008
    ..We tested the hypothesis that intravenous iron improves exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure (CHF) and iron deficiency...
  27. ncbi Intravenous ferric carboxymaltose compared with oral iron in the treatment of postpartum anemia: a randomized controlled trial
    David B Van Wyck
    Arizona Health Sciences Center, University of Arizona College of Medicine, 1821 East Elm Street, Tucson, AZ 85719, USA
    Obstet Gynecol 110:267-78. 2007
    ..To estimate efficacy of rapid, large-dose intravenous (IV) administration of ferric carboxymaltose compared with oral iron therapy in anemic postpartum women...
  28. ncbi Intravenous iron alone for the treatment of anemia in patients with chronic heart failure
    Aidan P Bolger
    Department of Clinical Cardiology, The Heart Hospital, London, United Kingdom
    J Am Coll Cardiol 48:1225-7. 2006
    ..This study was undertaken to assess the hematologic, clinical, and biochemical response to intravenous iron in patients with chronic heart failure (CHF) and anemia...
  29. pmc MRI-visible micellar nanomedicine for targeted drug delivery to lung cancer cells
    Jagadeesh Setti Guthi
    Department of Pharmacology, Simmons Comprehensive Cancer Center, Department of Internal Medicine, Division of Translational Research, and Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Mol Pharm 7:32-40. 2010
    ..3 +/- 6.4 nM and 73.6 +/- 6.3 nM, respectively; p < 0.005). The integrated diagnostic and therapeutic design of MFM nanomedicine potentially allows for image-guided, target-specific treatment of lung cancer...
  30. doi Iron oxide nanoparticle-containing microbubble composites as contrast agents for MR and ultrasound dual-modality imaging
    Zhe Liu
    Department of Experimental Molecular Imaging ExMI, Helmholtz Institute for Biomedical Engineering, Medical Faculty, RWTH Aachen University, Aachen 52074, Germany
    Biomaterials 32:6155-63. 2011
    ....
  31. pmc Formulation of novel lipid-coated magnetic nanoparticles as the probe for in vivo imaging
    Huey Chung Huang
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Biomed Sci 16:86. 2009
    ..Here, we formulated new cationic lipid nanoparticles containing SPIOs feasible for in vivo imaging...
  32. ncbi Microbial nanowires: a new paradigm for biological electron transfer and bioelectronics
    Nikhil S Malvankar
    Department of Microbiology, University of Massachusetts, Amherst, 203, Morrill Science Center IVN, 639 North Pleasant Street, Amherst, MA 01003, USA
    ChemSusChem 5:1039-46. 2012
    ....
  33. ncbi Superparamagnetic nanoparticle-inclusion microbubbles for ultrasound contrast agents
    Fang Yang
    State Key Laboratory of Bioelectronics, Jiangsu Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, Peoples Republic of China
    Phys Med Biol 53:6129-41. 2008
    ....
  34. doi FMN-coated fluorescent iron oxide nanoparticles for RCP-mediated targeting and labeling of metabolically active cancer and endothelial cells
    Jabadurai Jayapaul
    Department of Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany
    Biomaterials 32:5863-71. 2011
    ..This was shown for FLUSPIO, which due to their high T(2)-relaxivity, are favorably suited for MR cell tracking experiments and cancer detection in vivo...
  35. ncbi From iron oxide nanoparticles towards advanced iron-based inorganic materials designed for biomedical applications
    Albert Figuerola
    Istituto Italiano di Tecnologia, 16163 Genova, Italy
    Pharmacol Res 62:126-43. 2010
    ..In our discussion we will focus on those works that have provided a sound proof of concept on the potential of the various systems as diagnostic and therapeutic agents...
  36. doi Interactions between sub-10-nm iron and cerium oxide nanoparticles and 3T3 fibroblasts: the role of the coating and aggregation state
    M Safi
    Matiere et Systemes Complexes, UMR 7057 CNRS, Université Denis Diderot Paris VII, Batiment Condorcet, 10 rue Alice Domon et Leonie Duquet, Paris, France
    Nanotechnology 21:145103. 2010
    ..In conclusion, we show that the uptake of nanomaterials by living cells depends on the coating of the particles and on its ability to preserve the colloidal nature of the dispersions...
  37. ncbi Uptake and biological responses to nano-Fe versus soluble FeCl3 in excised mussel gills
    Eniko Kadar
    Plymouth Marine Laboratory, Prospect Place, The Hoe, Plymouth PL1 3DH, UK
    Anal Bioanal Chem 396:657-66. 2010
    ..However, with the use of nano-Fe as a food additive, clearly longer-term in vivo studies are warranted...
  38. pmc SidL, an Aspergillus fumigatus transacetylase involved in biosynthesis of the siderophores ferricrocin and hydroxyferricrocin
    Michael Blatzer
    Division of Molecular Biology, Biocenter, Fritz Pregl Str 3, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Appl Environ Microbiol 77:4959-66. 2011
    ..Moreover, this study revealed the unexpected complexity of siderophore biosynthesis, indicating the existence of an additional, iron-repressed N(5)-hydroxyornithine-acetylase...
  39. pmc In vivo tracking of mesenchymal stem cells labeled with a novel chitosan-coated superparamagnetic iron oxide nanoparticles using 3.0T MRI
    Alavala Matta Reddy
    Department of Radiology, Chung Ang University College of Medicine, Seoul, Korea
    J Korean Med Sci 25:211-9. 2010
    ..The migration of cells was also confirmed by histological studies. The novel chitosan-SPIO enables to label and track MSC for in vivo MRI without cellular alteration...
  40. pmc Lithotrophic iron-oxidizing bacteria produce organic stalks to control mineral growth: implications for biosignature formation
    Clara S Chan
    Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, Woods Hole, MA, USA
    ISME J 5:717-27. 2011
    ..We suggest that stalk-like morphologies observed in modern and ancient samples may be correlated confidently with the Fe-oxidizing metabolism as a robust biosignature...
  41. doi An in vitro study of bare and poly(ethylene glycol)-co-fumarate-coated superparamagnetic iron oxide nanoparticles: a new toxicity identification procedure
    Morteza Mahmoudi
    Institute for Nanoscience and Nanotechnology, Sharif University of Technology, Tehran, Iran
    Nanotechnology 20:225104. 2009
    ..It is shown that a more reliable way of identifying cytotoxicity for in vitro assessments is to use particles with saturated surfaces via interactions with DMEM before usage...
  42. pmc EGFRvIII antibody-conjugated iron oxide nanoparticles for magnetic resonance imaging-guided convection-enhanced delivery and targeted therapy of glioblastoma
    Costas G Hadjipanayis
    Brain Tumor Nanotechnology Laboratory, Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 70:6303-12. 2010
    ....
  43. ncbi Intravenous iron administration in a short-stay hospital setting
    George Peebles
    Department of Renal Medicine, Sunderland Royal Hospital, Sunderland
    Nurs Stand 22:35-41. 2008
    ..In this arena the role of intravenous (IV) iron is well established. This article describes how IV iron may be given in total doses in a short-stay hospital setting...
  44. ncbi Iron metabolism in pathogenic bacteria
    C Ratledge
    Department of Biological Sciences, University of Hull, Hull HU6 7RX
    Annu Rev Microbiol 54:881-941. 2000
    ..In this way, the biochemistry of the bacterial cell can accommodate the challenges from the host. Agents that interfere with bacterial iron metabolism may prove extremely valuable for chemotherapy of diseases...
  45. pmc MR tracking of transplanted cells with "positive contrast" using manganese oxide nanoparticles
    Assaf A Gilad
    Russell H Morgan Department of Radiology, Division of MR Research, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Magn Reson Med 60:1-7. 2008
    ..Simultaneous imaging of both transplants with opposite contrast offers a method for MR "double labeling" of different cell populations...
  46. ncbi Sodium ferric gluconate complex in hemodialysis patients: adverse reactions compared to placebo and iron dextran
    Beckie Michael
    Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Kidney Int 61:1830-9. 2002
    ..S. under FDA's priority drug review. This Phase IV study was designed to evaluate the safety of a single dose of intravenous SFGC as compared to placebo and a historical iron dextran control...
  47. ncbi Application of the static dephasing regime theory to superparamagnetic iron-oxide loaded cells
    Chris V Bowen
    Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    Magn Reson Med 48:52-61. 2002
    ..This work is an important first step in quantifying cellular iron content and ultimately mapping the density of a targeted cell population...
  48. doi Ferric carboxymaltose: a review of its use in iron-deficiency anaemia
    Katherine A Lyseng-Williamson
    Wolters Kluwer Health mid R Adis, Auckland, New Zealand, an editorial office of Wolters Kluwer Health, Philadelphia, Pennsylvania, USA
    Drugs 69:739-56. 2009
    ..In patients with chronic kidney disease undergoing haemodialysis, a lower proportion of ferric carboxymaltose than iron sucrose recipients experienced at least one drug-related adverse event...
  49. pmc Specific targeting of brain tumors with an optical/magnetic resonance imaging nanoprobe across the blood-brain barrier
    Omid Veiseh
    Departments of Materials Science and Engineering, University of Washington, Seattle, Washington 99195, USA
    Cancer Res 69:6200-7. 2009
    ....
  50. ncbi Cell tagging with clinically approved iron oxides: feasibility and effect of lipofection, particle size, and surface coating on labeling efficiency
    Lars Matuszewski
    Department of Clinical Radiology, University Hospital Muenster, Albert Schweitzer Strasse 33, D 48129 Muenster, Germany
    Radiology 235:155-61. 2005
    ..To evaluate the effect of lipofection, particle size, and surface coating on labeling efficiency of mammalian cells with superparamagnetic iron oxides (SPIOs)...
  51. pmc Reversal of multidrug resistance by magnetic Fe3O4 nanoparticle copolymerizating daunorubicin and 5-bromotetrandrine in xenograft nude-mice
    Baoan Chen
    Department of Hematology, Zhongda Hospital, Southeast University, Nanjing, 210009, PR China
    Int J Nanomedicine 4:73-8. 2009
    ..It is concluded that 5-BrTet and MNP-Fe(3)O(4) combined with DNR had a significant tumor-suppressing effect on a MDR leukemia cells xenograft model...
  52. doi Effect of surface charge and agglomerate degree of magnetic iron oxide nanoparticles on KB cellular uptake in vitro
    Yuqing Ge
    State Key Laboratory of Bioelectronics, Jiangsu Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, PR China
    Colloids Surf B Biointerfaces 73:294-301. 2009
    ..5T clinical MR imager. The finding of this study will have implications in the chemical design of nanomaterials for biomedical applications...
  53. ncbi Ferric carboxymaltose injection in the treatment of postpartum iron deficiency anemia: a randomized controlled clinical trial
    Melvin H Seid
    Lyndhurst Gynecologic Associates, Winston Salem, NC 27103, USA
    Am J Obstet Gynecol 199:435.e1-7. 2008
    ..The objective of the study was to evaluate the efficacy, safety, and tolerability of intravenous ferric carboxymaltose, compared with oral ferrous sulfate in women with postpartum anemia...
  54. doi FGF23 elevation and hypophosphatemia after intravenous iron polymaltose: a prospective study
    Belinda J Schouten
    Department of Endocrinology, Christchurch Hospital, Christchurch, New Zealand
    J Clin Endocrinol Metab 94:2332-7. 2009
    ..We recently reported a case of iron-induced hypophosphatemic osteomalacia associated with marked FGF23 elevation...
  55. pmc Evaluation of iron oxide nanoparticle biocompatibility
    Amel Hanini
    Interface Traitement, Organisation et Dynamique des Systemes, Universite Paris 7, Paris, France
    Int J Nanomedicine 6:787-94. 2011
    ..In conclusion, γ-Fe(2)O(3) could exhibit harmful properties and therefore surface coating, cellular targeting, and local exposure should be considered before developing clinical applications...
  56. ncbi Intravenous iron without erythropoietin for the treatment of iron deficiency anemia in patients with moderate to severe congestive heart failure and chronic kidney insufficiency
    Rustam I Usmanov
    Republican Research Center of Emergency Medicine of Uzbekistan, Tashkent, Uzbekistan
    J Nephrol 21:236-42. 2008
    ..The purpose of this study was to assess the effect of intravenous (i.v.) iron on the anemia of CHF patients and on cardiac remodeling, New York Heart Association (NYHA) classification and renal function...
  57. doi Dual drug loaded superparamagnetic iron oxide nanoparticles for targeted cancer therapy
    Fahima Dilnawaz
    Laboratory of Nanomedicine, Institute of Life Sciences, Nalco Square, Chandrasekharpur, Bhubaneswar 751023, Orissa, India
    Biomaterials 31:3694-706. 2010
    ..The IC(50) doses revealed potential antiproliferative effect in MCF-7. Therefore, antibody conjugated GMO-MNPs could be used as potential drug carrier for the active therapeutic aspects in cancer therapy...
  58. doi Superparamagnetic iron oxide nanoparticle-embedded encapsulated microbubbles as dual contrast agents of magnetic resonance and ultrasound imaging
    Fang Yang
    Jiangsu Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
    Biomaterials 30:3882-90. 2009
    ..Therefore, the proposed SPIO nanoparticle-embedded EMBs potentially can become effective MR susceptibility contrast agents while also can be good US contrast agents...
  59. doi Drug-loaded superparamagnetic iron oxide nanoparticles for combined cancer imaging and therapy in vivo
    Mi Kyung Yu
    Research Center for Biomolecular Nanotechnology, Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryong dong, Buk Gu, Gwangju 500 712, South Korea
    Angew Chem Int Ed Engl 47:5362-5. 2008
  60. pmc Current production and metal oxide reduction by Shewanella oneidensis MR-1 wild type and mutants
    Orianna Bretschger
    Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, California 90089, USA
    Appl Environ Microbiol 73:7003-12. 2007
    ..Overall, these data suggest a very complex picture of electron transfer to solid and soluble substrates by S. oneidensis MR-1...
  61. ncbi Development of superparamagnetic nanoparticles for MRI: effect of particle size, charge and surface nature on biodistribution
    C Chouly
    Laboratoire de Biophysique, Faculte de Medecine, Angers, France
    J Microencapsul 13:245-55. 1996
    ..It was up to 3 X lower for electrically neutral particles than for charged particles. Coated particles presented higher vascular persistence. The diagnostic potential for liver, lymph node or vascular imaging were discussed...
  62. ncbi Hypersensitivity reactions and deaths associated with intravenous iron preparations
    George R Bailie
    Albany Nephrology Pharmacy ANephRx Group, Albany, NY, USA
    Nephrol Dial Transplant 20:1443-9. 2005
    ..We used the US Food and Drug Administration's Freedom of Information (FOI) surveillance database to compare the type 1 AE profiles for the three intravenous iron preparations available in the United States...
  63. pmc Induction of inflammation in vascular endothelial cells by metal oxide nanoparticles: effect of particle composition
    Andrea Gojova
    Department of Mechanical and Aeronautical Engineering, University of California, Davis, Davis, California, USA
    Environ Health Perspect 115:403-9. 2007
    ..Ultrafine particles appear to cross the pulmonary epithelial barrier into the bloodstream, raising the possibility of direct contact with the vascular endothelium...
  64. ncbi Vascular targeted nanoparticles for imaging and treatment of brain tumors
    G Ramachandra Reddy
    Molecular Therapeutics, Inc, Ann Arbor, MI 48109, USA
    Clin Cancer Res 12:6677-86. 2006
    ..The ability to directly target a therapeutic agent to a tumor site would minimize systemic drug exposure, thus providing the potential for increasing the therapeutic index...
  65. doi Extracellular electron transfer: wires, capacitors, iron lungs, and more
    Derek R Lovley
    Department of Microbiology, University of Massachusetts, Amherst, MA 01003, USA
    Geobiology 6:225-31. 2008
  66. ncbi In vivo magnetic resonance tracking of magnetically labeled cells after transplantation
    Jeff W M Bulte
    Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
    J Cereb Blood Flow Metab 22:899-907. 2002
    ..Now that MR tracking of magnetically labeled cells appears feasible, it is anticipated that this technique may ultimately become an important tool for monitoring the efficacy of clinical (stem) cell transplantation protocols...
  67. ncbi In vivo MRI of brain inflammation in human ischaemic stroke
    Andreas Saleh
    Instritute of Diagnostic, University Hospital, Heinrich Heine University, Dusseldorf, Germany
    Brain 127:1670-7. 2004
    ..Thus, USPIO-enhanced MRI may provide an in vivo surrogate marker of cellular inflammation in stroke and other CNS pathologies...
  68. pmc Dissimilatory Fe(III) and Mn(IV) reduction by Shewanella putrefaciens requires ferE, a homolog of the pulE (gspE) type II protein secretion gene
    Thomas J DiChristina
    School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30332 0230, USA
    J Bacteriol 184:142-51. 2002
    ..putrefaciens proteins involved in anaerobic respiration on Fe(III) and Mn(IV)...
  69. ncbi The application of Fe3O4 nanoparticles in cancer research: a new strategy to inhibit drug resistance
    Xuemei Wang
    State Key Lab of Bioelectronics, Chien Shiung WU Laboratory, Southeast University, Nanjing 210096, People s Republic of China
    J Biomed Mater Res A 80:852-60. 2007
    ....
  70. doi Large-dose intravenous ferric carboxymaltose injection for iron deficiency anemia in heavy uterine bleeding: a randomized, controlled trial
    David B Van Wyck
    DaVita, Inc, Tucson, Arizona, USA
    Transfusion 49:2719-28. 2009
    ..The objective was to evaluate efficacy and safety of rapid, large-dose intravenous (IV) administration of ferric carboxymaltose compared to oral iron in correcting iron deficiency anemia due to heavy uterine bleeding...
  71. pmc Antioxidant activities and phenolic contents of the methanol extracts of the stems of Acokanthera oppositifolia and Adenia gummifera
    Adeolu A Adedapo
    Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Ibadan, Nigeria
    BMC Complement Altern Med 8:54. 2008
    ..Antioxidants thus play an important role of protecting the human body against damage by the free radicals. Plants containing phenolic compounds have been reported to possess strong antioxidant properties...
  72. doi Catechol derivatives-coated Fe3O4 and gamma-Fe2O3 nanoparticles as potential MRI contrast agents
    H Basti
    ITODYS, Université Paris 7 CNRS UMR 7086, 15, rue Jean Antoine de Baif, 75205 Paris Cedex 13, France
    J Colloid Interface Sci 341:248-54. 2010
    ....
  73. doi Cell labelling with superparamagnetic iron oxide has no effect on chondrocyte behaviour
    E Farrell
    Department of Orthopaedics, Erasmus University Medical Centre, Rotterdam, Netherlands
    Osteoarthritis Cartilage 17:961-7. 2009
    ..It is non-radioactive, does not require viral transfection and is already approved for clinical use as a contrast agent...
  74. doi Using thermal energy produced by irradiation of Mn-Zn ferrite magnetic nanoparticles (MZF-NPs) for heat-inducible gene expression
    Qiu sha Tang
    School of Clinical Medical Science, Southeast University, Nanjing 210009, China
    Biomaterials 29:2673-9. 2008
    ..This novel system made use of the relative low Curie point of MZF-NPs to control the in vivo hyperthermia temperature and therefore acquired safe and effective heat-inducible transgene expression...
  75. doi Poly(L-lysine)-modified iron oxide nanoparticles for stem cell labeling
    Michal Babic
    Institute of Macromolecular Chemistry, v v i, Academy of Sciences of the Czech Republic, Heyrovsky Sq 2, 162 06 Prague 6, Czech Republic
    Bioconjug Chem 19:740-50. 2008
    ..In comparison with Endorem, nanoparticles modified with PLL of an optimum molecular weight demonstrated a higher efficiency of intracellular uptake by MSC cells...
  76. ncbi Carboxylated superparamagnetic iron oxide particles label cells intracellularly without transfection agents
    Volker Mailänder
    Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, Institute of Transfusion Medicine, University of Ulm, Helmholtzstr 10, 89081 Ulm, Germany
    Mol Imaging Biol 10:138-46. 2008
    ..A steady increase in uptake of nanoparticles was detected with a higher density of carboxyl groups showing the relevance of charged groups as in the case of Resovist. Aggregation of these polymeric nanoparticles was not found...
  77. ncbi MRI of monocyte infiltration in an animal model of neuroinflammation using SPIO-labeled monocytes or free USPIO
    Raoul D Oude Engberink
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 28:841-51. 2008
    ..The use of SPIO-labeled monocytes provides a better tool to specifically assess the time window of monocyte infiltration...
  78. ncbi Specific targeting of tumor angiogenesis by RGD-conjugated ultrasmall superparamagnetic iron oxide particles using a clinical 1.5-T magnetic resonance scanner
    Chunfu Zhang
    Junior Group Molecular Imaging, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Cancer Res 67:1555-62. 2007
    ..Furthermore, these molecular MR imaging probes are capable of distinguishing tumors differing in the degree of alpha(v)beta(3) integrin expression and in their angiogenesis profile even when using a clinical 1.5-T MR scanner...
  79. ncbi Capacity of human monocytes to phagocytose approved iron oxide MR contrast agents in vitro
    Stephan Metz
    Department of Diagnostic Radiology, Technical University Munich, Munich, Germany
    Eur Radiol 14:1851-8. 2004
    ..In vitro labeling of human monocytes for MR imaging is most effectively obtained with the approved SPIO Ferucarbotran. Potential subsequent in vivo cell tracking applications comprise, e.g. specific targeting of inflammatory processes...
  80. ncbi Iron supplementation in pregnancy--does the preparation matter?
    Nir Melamed
    Department of Obstetrics and Gynecology, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tiqwa, 49100, Israel
    Arch Gynecol Obstet 276:601-4. 2007
    ..To assess the use, side effects and discontinuation rates of iron preparations during pregnancy...
  81. pmc Respiration of metal (hydr)oxides by Shewanella and Geobacter: a key role for multihaem c-type cytochromes
    Liang Shi
    Pacific Northwest National Laboratory, Richland, Washington 99354, USA
    Mol Microbiol 65:12-20. 2007
    ..Thus, multihaem c-Cyts play critical roles in S. oneidensis MR-1- and G. sulfurreducens-mediated dissimilatory reduction of solid metal (hydr)oxides by facilitating ET across the bacterial cell envelope...
  82. ncbi Silica- and alkoxysilane-coated ultrasmall superparamagnetic iron oxide particles: a promising tool to label cells for magnetic resonance imaging
    Chunfu Zhang
    Junior Group Molecular Imaging and Departments of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany
    Langmuir 23:1427-34. 2007
    ..This suggests silica-coated USPIO particles are most suited for cell labeling approaches in MRI...
  83. doi Manganese ferrite nanoparticle micellar nanocomposites as MRI contrast agent for liver imaging
    Jian Lu
    National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China
    Biomaterials 30:2919-28. 2009
    ..This sensitive MRI contrast agent may find applications in identification of small liver lesions, evaluation of the degree of liver cirrhosis, and differential diagnosis of other liver diseases...
  84. pmc Systematic surface engineering of magnetic nanoworms for in vivo tumor targeting
    Ji Ho Park
    Materials Science and Engineering Program Department of Chemistry and Biochemistry University of California, San Diego 9500 Gilman, La Jolla, CA 92093, USA
    Small 5:694-700. 2009
    ..It is concluded that the blood half-life of a targeting molecule-nanomaterial ensemble is a key consideration when selecting the appropriate ligand and nanoparticle chemistry for tumor targeting...
  85. pmc Enhancement of the efficiency of non-viral gene delivery by application of pulsed magnetic field
    Sarah W Kamau
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Nucleic Acids Res 34:e40. 2006
    ..The highly efficient gene transfer already within 5 min shows that this technique is a powerful tool for future in vivo studies, where rapid gene delivery is required before systemic clearance or filtration of the gene vectors occurs...
  86. doi In vivo MRI stem cell tracking requires balancing of detection limit and cell viability
    K Nohroudi
    Department of Anatomy I, University of Cologne, Cologne, Germany
    Cell Transplant 19:431-41. 2010
    ..Conclusively, though careful titration is indicated, MPIOs are a promising tool for in vivo cell tracking and evaluation of cell-based therapies...
  87. ncbi Use of parenteral iron products and serious anaphylactic-type reactions
    Diane K Wysowski
    Office of Surveillance and Epidemiology, Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA
    Am J Hematol 85:650-4. 2010
    ..To help differentiate risk among the parenteral iron products, the brand name of the product always should be provided on medical records, death certificates, and adverse drug reaction reports...
  88. ncbi Characterization of the ferrioxamine uptake system of Nitrosomonas europaea
    Xueming Wei
    Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331 2902, USA
    Microbiology 153:3963-72. 2007
    ..For efficient acquisition of Fe-loaded ferrioxamine, N. europaea needs both ferrioxamine transporters FoxA(1) and FoxA(2). FoxA(1) probably regulates its own production, and it controls the production of FoxA(2) as well...
  89. doi In vivo MR imaging tracking of magnetic iron oxide nanoparticle labeled, engineered, autologous bone marrow mesenchymal stem cells following intra-articular injection
    Xu hong Jing
    Center of Joint Surgery, Southwest Hospital, The Third Military Medical University, Chongqing, China
    Joint Bone Spine 75:432-8. 2008
    ..5T-system following injection of engineered autologous MSCs into the knee joint cavity in rabbit articular cartilage defect models...
  90. ncbi Dissimilatory Fe(III) and Mn(IV) reduction
    Derek R Lovley
    Department of Microbiology, University of Massachusetts Amherst, Amherst, MA 01003, USA
    Adv Microb Physiol 49:219-86. 2004
    ..In comparison with other respiratory processes, the study of Fe(III) and Mn(IV) reduction is in its infancy, but genome-enabled approaches are rapidly advancing our understanding of this environmentally significant physiology...
  91. doi Imaging and cell targeting characteristics of magnetic nanoparticles modified by a functionalizable zwitterionic polymer with adhesive 3,4-dihydroxyphenyl-l-alanine linkages
    Lei Zhang
    Department of Chemical Engineering, University of Washington, Box 351750, Seattle, WA 98195, United States
    Biomaterials 31:6582-8. 2010
    ....
  92. doi Variations in labeling protocol influence incorporation, distribution and retention of iron oxide nanoparticles into human umbilical vein endothelial cells
    Sandra T van Tiel
    Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Contrast Media Mol Imaging 5:247-57. 2010
    ..Consequently, for each cell type separately an optimal protocol has to be established...
  93. ncbi Update on adverse drug events associated with parenteral iron
    Glenn M Chertow
    Department of Medicine, University of California San Francisco, UCSF Laurel Heights Suite 430, 3333 California Street, San Francisco, CA 94118 1211, USA
    Nephrol Dial Transplant 21:378-82. 2006
    ..Since that time, iron sucrose has become widely available and clinicians have gained additional experience with sodium ferric gluconate complex...
  94. ncbi Conformation-specific blockade of the integrin GPIIb/IIIa: a novel antiplatelet strategy that selectively targets activated platelets
    Meike Schwarz
    Department of Cardiology, University of Freiburg, Freiburg, Germany
    Circ Res 99:25-33. 2006
    ..In conclusion, activation-specific GPIIb/IIIa blockade via human single-chain antibodies represents a promising novel strategy for antiplatelet therapy...
  95. pmc Receptor-targeted nanoparticles for in vivo imaging of breast cancer
    Lily Yang
    Department of Surgery and Winship Cancer Institute, Emory University School of Medicine, C 4088, 1365 C Clifton Road NE, Atlanta, GA 30322, USA
    Clin Cancer Res 15:4722-32. 2009
    ..Cell-surface receptor-targeted magnetic iron oxide nanoparticles provide molecular magnetic resonance imaging contrast agents for improving specificity of the detection of human cancer...
  96. doi Self-assembled simple hexagonal AB(2) binary nanocrystal superlattices: SEM, GISAXS, and defects
    Danielle K Smith
    Department of Chemical Engineering, Texas Materials Institute, Center for Nano and Molecular Science and Technology, The University of Texas at Austin, Austin, Texas 78712 1062, USA
    J Am Chem Soc 131:3281-90. 2009
    ..Additionally, nearly periodic superlattice dislocations consisting of inserted half-planes of gold nanocrystals were observed by SEM in some BSLs...
  97. doi A human ferritin iron oxide nano-composite magnetic resonance contrast agent
    Masaki Uchida
    Department of Chemistry and Biochemistry, Montana State University, Bozeman, Montana 59715, USA
    Magn Reson Med 60:1073-81. 2008
    ..These results encourage further investigation into the development of the rHFn-iron oxide contrast agent to assess inflammatory disease status such as macrophage-rich atherosclerotic plaques in vivo...
  98. pmc Magnetic nanoparticle of Fe3O4 and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells
    Baoan Chen
    Department of Hematology, The Affi liated Zhongda Hospital, Clinical Medical School, Southeast University, Nanjing, 210009 P R China
    Int J Nanomedicine 4:65-71. 2009
    ..Thus our in vitro data strongly suggests a potential clinical application of MNP(Fe(3)O(4)) and BrTet combination on CML...
  99. ncbi Intravenous iron sucrose versus oral iron supplementation for the treatment of iron deficiency anemia in patients with inflammatory bowel disease--a randomized, controlled, open-label, multicenter study
    Oliver Schroder
    First Department of Internal Medicine, Division of Gastroenterology, ZAFES, Johann Wolfgang Goethe University, Frankfurt, Germany
    Am J Gastroenterol 100:2503-9. 2005
    ..We therefore evaluated the efficacy and safety of intravenous iron sucrose as compared with oral iron sulfate for the treatment of iron deficiency anemia (IDA) in patients with IBD...
  100. ncbi High-resolution MR imaging of mouse brain microvasculature using the relaxation rate shift index Q
    Ed X Wu
    Jockey Club MRI Engineering Centre and Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, People s Republic of China
    NMR Biomed 17:507-12. 2004
    ..Microvessel densities estimated from the Q-maps are found to be in reasonable accord with histologically determined values. A possible application of Q-maps is the assessment of angiogenic activity in tumors...
  101. ncbi Magnetic labeling of non-phagocytic adherent cells with iron oxide nanoparticles: a comprehensive study
    Sebastien Boutry
    Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons Hainaut, Mons, Belgium
    Contrast Media Mol Imaging 3:223-32. 2008
    ..The viability of cells, estimated by methods assessing cell membrane permeability, was not affected by magnetic labeling in the conditions used in this work...

Research Grants133 found, 100 shown here

  1. Biomimetic Studies of NO-binding Respiratory Chain Hemes
    JAMES COLLMAN; Fiscal Year: 2007
    ..An emphasis will be placed on kinetic and mechanistic studies to elucidate the putitive reaction pathways of CcO and NOR. ..
  2. Quantitative Subharmonic Breast Imaging
    Flemming Forsberg; Fiscal Year: 2010
    ....
  3. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2007
    ..Evaluation of such strategies will improve BP control in hemodialysis patients and, in the long-term, provide cardiovascular protection. ..
  4. Pathobiology of Kidney Disease: Role of Iron
    Rajiv Agarwal; Fiscal Year: 2008
    ..Novelty and Health Relatedness of the Project: This proposal will provide translational data on the role of intravenous iron to progression of kidney disease in patients with CKD. ..
  5. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2005
    ..Evaluation of such strategies will improve BP control in hemodialysis patients and, in the long-term, provide cardiovascular protection. ..
  6. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2004
    ..Evaluation of such strategies will improve BP control in hemodialysis patients and, in the long-term, provide cardiovascular protection. ..
  7. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2006
    ..Evaluation of such strategies will improve BP control in hemodialysis patients and, in the long-term, provide cardiovascular protection. ..
  8. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2003
    ..Evaluation of such strategies will improve BP control in hemodialysis patients and, in the long-term, provide cardiovascular protection. ..
  9. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2010
    ..We hypothesize that that volume control can improve BP and antihypertensive therapy can regress left ventricular hypertrophy in long-term hemodialysis patients. ..
  10. DETERMINING THE GENETICS OF RESTLESS LEGS SYNDROME
    Christopher Earley; Fiscal Year: 2002
    ....
  11. Restless Legs Syndrome- The Iron-Dopamine Connection
    Christopher Earley; Fiscal Year: 2008
    ..4) Investigators will use sophisticated PET, MRI, neuropathological, biological, and mice inbreeding approaches that have been incorporated to facilitate novel insights into the interaction of iron, dopamine and their relevance to RLS. ..
  12. Response to Iron Treatment for Restless Leg Syndrome
    Christopher Earley; Fiscal Year: 2002
    ..An expected finding that IV iron reduces the brain iron insufficiency and dramatically reduces the RLS symptoms strongly supports our model of RLS caused by brain iron insufficiency. ..
  13. Chronic Renal Insufficiency in NAPRTCS Patients
    Bradley Warady; Fiscal Year: 2007
    ..abstract_text> ..
  14. DOPAMINERGIC FUNCTION IN RESTLESS LEGS SYNDROME
    Christopher Earley; Fiscal Year: 2000
    ..The authors would also explore relationships between iron and CSF measures of dopaminergic activities, which could provide the basis for entirely new research and treatment approaches to RLS. ..
  15. DETERMINING THE GENETICS OF RESTLESS LEGS SYNDROME
    Christopher Earley; Fiscal Year: 2000
    ....
  16. Genetic Response to Low Dietary Iron in BXD RI Mice
    Christopher Earley; Fiscal Year: 2008
    ..We will then look for the genes that regulate expression of these iron-related protein genes. [unreadable] [unreadable] [unreadable]..
  17. Low-Cost Digital Imaging System for Evaluating Thrombosis
    Brian Cooley; Fiscal Year: 2008
    ..This imaging methodology may have a capacity for future adaptation to clinical thrombosis imaging. [unreadable] [unreadable] [unreadable]..
  18. Dopamine and Iron in Restless Legs Syndrome
    Christopher Earley; Fiscal Year: 2004
    ..Using CSF and MRI measurements of iron will assess the CNS iron status. RLS severity will be based on subjective (rating scale and diary) and objective (PSG) measurements. ..
  19. Response to Iron Treatment for Restless Leg Syndrome
    Christopher Earley; Fiscal Year: 2004
    ..An expected finding that IV iron reduces the brain iron insufficiency and dramatically reduces the RLS symptoms strongly supports our model of RLS caused by brain iron insufficiency. ..
  20. Effect of Age on Vein Graft Neointimal Formation
    Brian Cooley; Fiscal Year: 2003
    ..Furthermore, the establishment of an age-associated model of vein grafting will permit age-specific evaluation of new therapeutic avenues for inhibiting neointimal formation. ..
  21. Dopamine and Iron in Restless Legs Syndrome
    Christopher Earley; Fiscal Year: 2006
    ..Using CSF and MRI measurements of iron will assess the CNS iron status. RLS severity will be based on subjective (rating scale and diary) and objective (PSG) measurements. ..
  22. Chronic Kidney Disease in Children (CKiD)
    Bradley Warady; Fiscal Year: 2008
    ....
  23. Effect of Osteoporosis on Spine Fusion
    Brian Cooley; Fiscal Year: 2008
    ..Understanding how an osteoporotic predisposition influences spine fusion healing and remodeling is critical for developing better therapeutic options for these patients. ..
  24. DETERMINING THE GENETICS OF RESTLESS LEGS SYNDROME
    Christopher Earley; Fiscal Year: 2003
    ....
  25. Response to Iron Treatment for Restless Leg Syndrome
    Christopher Earley; Fiscal Year: 2003
    ..An expected finding that IV iron reduces the brain iron insufficiency and dramatically reduces the RLS symptoms strongly supports our model of RLS caused by brain iron insufficiency. ..
  26. Dopamine and Iron in Restless Legs Syndrome
    Christopher Earley; Fiscal Year: 2003
    ..Using CSF and MRI measurements of iron will assess the CNS iron status. RLS severity will be based on subjective (rating scale and diary) and objective (PSG) measurements. ..
  27. Functional active-site models of cytochrome c oxidase
    JAMES COLLMAN; Fiscal Year: 2005
    ..The role that the copper ion (CuB) and a phenolic group, in the amino acid tyrosine (Tyr-244) play in the catalytic function of CcO are of particular interest. ..
  28. FUNCTIONAL ANALOGUES OF 02 BINDING/ACTIVATING HEME SITES
    JAMES COLLMAN; Fiscal Year: 1999
    ..The role of distal steric effects and of H-bonding will be explored. The NO binding has relevance to many medical problems related to activation by the gaseous hormone, NO. Examples include vasodilation and neurotransmission. ..
  29. Functional active-site models of cytochrome c oxidase
    JAMES COLLMAN; Fiscal Year: 2009
    ..The role that the copper ion (CuB) and a phenolic group, in the amino acid tyrosine (Tyr244) play in the catalytic function of CcO are of particular interest. ..
  30. Functional active-site models of cytochrome c oxidase
    JAMES COLLMAN; Fiscal Year: 2003
    ..The role that the copper ion (CuB) and a phenolic group, in the amino acid tyrosine (Tyr-244) play in the catalytic function of CcO are of particular interest. ..
  31. Biomimetic Studies of NO-binding Respiratory Chain Hemes
    JAMES COLLMAN; Fiscal Year: 2008
    ..An emphasis will be placed on kinetic and mechanistic studies to elucidate the putitive reaction pathways of CcO and NOR. ..
  32. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2006
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  33. ACUTE RENAL FAILURE--MECHANISMS AND ADAPTIVE RESPONSES
    RICHARD ZAGER; Fiscal Year: 2000
    ....
  34. Functional active-site models of cytochrome c oxidase
    JAMES COLLMAN; Fiscal Year: 2007
    ..The role that the copper ion (CuB) and a phenolic group, in the amino acid tyrosine (Tyr244) play in the catalytic function of CcO are of particular interest. ..
  35. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2000
    ....
  36. Functional active-site models of cytochrome c oxidase
    JAMES COLLMAN; Fiscal Year: 2006
    ..The role that the copper ion (CuB) and a phenolic group, in the amino acid tyrosine (Tyr244) play in the catalytic function of CcO are of particular interest. ..
  37. Functional active-site models of cytochrome c oxidase
    JAMES COLLMAN; Fiscal Year: 2002
    ..The role that the copper ion (CuB) and a phenolic group, in the amino acid tyrosine (Tyr-244) play in the catalytic function of CcO are of particular interest. ..
  38. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2007
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  39. Biomimetic Studies of NO-binding Respiratory Chain Hemes
    JAMES COLLMAN; Fiscal Year: 2006
    ..An emphasis will be placed on kinetic and mechanistic studies to elucidate the putitive reaction pathways of CcO and NOR. ..
  40. FUNCTIONAL ANALOGUES OF 02 BINDING/ACTIVATING HEME SITES
    JAMES COLLMAN; Fiscal Year: 2000
    ..The role of distal steric effects and of H-bonding will be explored. The NO binding has relevance to many medical problems related to activation by the gaseous hormone, NO. Examples include vasodilation and neurotransmission. ..
  41. MODELS FOR CYTOCHROME P450 HYDROXYLASES
    JAMES COLLMAN; Fiscal Year: 1980
    ..To date, synthetic models for oxymyoglobin, deoxymyoglobin, and three states of cytochrome P-450 have been characterized. The vibrational frequency for coordinated dioxygen has been measured in both iron and cobalt porphyrin complexes...
  42. Subharmonic Microbubble Signals for Pressure Estimation
    Flemming Forsberg; Fiscal Year: 2008
    ..This will allow potentially life-threatening diseases, such as increased pressure in the liver, to be diagnosed early. [unreadable] [unreadable] [unreadable]..
  43. FUNCTIONAL ANALOGUES OF 02 BINDING/ACTIVATING HEME SITES
    JAMES COLLMAN; Fiscal Year: 2001
    ..The role of distal steric effects and of H-bonding will be explored. The NO binding has relevance to many medical problems related to activation by the gaseous hormone, NO. Examples include vasodilation and neurotransmission. ..
  44. ACUTE RENAL FAILURE--MECHANISMS AND ADAPTIVE RESPONSES
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  45. Acute Renal Failure: Mechanisms and Adaptive Responses
    RICHARD ZAGER; Fiscal Year: 2007
    ....
  46. Functional active-site models of cytochrome c oxidase
    JAMES COLLMAN; Fiscal Year: 2004
    ..The role that the copper ion (CuB) and a phenolic group, in the amino acid tyrosine (Tyr-244) play in the catalytic function of CcO are of particular interest. ..
  47. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  48. Subharmonic Microbubble Signals for Pressure Estimation
    Flemming Forsberg; Fiscal Year: 2007
    ..This will allow potentially life-threatening diseases, such as increased pressure in the liver, to be diagnosed early. [unreadable] [unreadable] [unreadable]..
  49. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 1999
    ....
  50. Functional active-site models of cytochrome c oxidase
    JAMES COLLMAN; Fiscal Year: 2008
    ..The role that the copper ion (CuB) and a phenolic group, in the amino acid tyrosine (Tyr244) play in the catalytic function of CcO are of particular interest. ..
  51. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  52. SPECTROSCOPIC STUDIES OF MOLYBDOENZYMES AND MODELS
    Martin Kirk; Fiscal Year: 2008
    ..Molybdenum enzymes are of key importance to human health. Our emerging understanding of their role in drug metabolism, free-radical damage, and the immune system underscore their role in a variety of health related issues. ..
  53. SPECTROSCOPIC STUDIES OF MOLYBDOENZYMES AND MODELS
    Martin Kirk; Fiscal Year: 2005
    ....
  54. Pathobiology of Kidney Disease: Role of Iron
    Rajiv Agarwal; Fiscal Year: 2007
    ..Novelty and Health Relatedness of the Project: This proposal will provide translational data on the role of intravenous iron to progression of kidney disease in patients with CKD. ..
  55. Matrix metalloproteinases as biomarkers of neurodegeneration
    Veronica Shubayev; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  56. Targeted Nanoprobes For Intraoperative optical Imaging of Breast Cancer Margins
    Lily Yang; Fiscal Year: 2010
    ....
  57. DRUGS & DELIVERY SYSTEMS FOR OPPORTUNISTIC INFESTIONS
    Marvin Miller; Fiscal Year: 1991
    ....
  58. SPECTROSCOPIC STUDIES OF MOLYBDOENZYMES AND MODELS
    Martin Kirk; Fiscal Year: 2001
    ..The results of the proposed research should lead to developing detailed mechanistic insight into gated electron transfer, oxygen atom transfer and the activation of C-H bonds for oxidative hydroxylation by [MoOS] units. ..
  59. Iron fMRI: Improving Sensitivty and localization
    JOSEPH MANDEVILLE; Fiscal Year: 2003
    ..abstract_text> ..
  60. THERAPEUTIC BENEFIT OF HYDROGEN PEROXIDE REMOVAL IN FALS
    JOSEPH PODUSLO; Fiscal Year: 2002
    ..This grant proposal, therefore, will further test whether this hypothesis-driven therapy is beneficial in the treatment of FALS transgenic mice, which will have direct implications for the treatment of both familial and sporadic ALS. ..
  61. IRON CHELATORS PREDICATED ON DESFERRITHIOCIN
    RAYMOND BERGERON; Fiscal Year: 2007
    ..abstract_text> ..
  62. DETERMINING THE GENETICS OF RESTLESS LEGS SYNDROME
    Christopher Earley; Fiscal Year: 2001
    ....
  63. DOPAMINERGIC FUNCTION IN RESTLESS LEGS SYNDROME
    Christopher Earley; Fiscal Year: 2001
    ..The authors would also explore relationships between iron and CSF measures of dopaminergic activities, which could provide the basis for entirely new research and treatment approaches to RLS. ..
  64. Design/Syntheses/Studies/Novel Antituberculosis Agents
    Marvin Miller; Fiscal Year: 2006
    ..tuberculosis. ..
  65. ORAL IRON CHELATORS PREDICATED ON DESFERRITHIOCIN
    RAYMOND BERGERON; Fiscal Year: 1999
    ..The development of a safe and orally effective iron chelator would be a major advance in the treatment of iron overload. ..
  66. Low-Cost Digital Imaging System for Evaluating Thrombosis
    Brian Cooley; Fiscal Year: 2007
    ..This imaging methodology may have a capacity for future adaptation to clinical thrombosis imaging. [unreadable] [unreadable] [unreadable]..
  67. Dopamine and Iron in Restless Legs Syndrome
    Christopher Earley; Fiscal Year: 2005
    ..Using CSF and MRI measurements of iron will assess the CNS iron status. RLS severity will be based on subjective (rating scale and diary) and objective (PSG) measurements. ..
  68. ACCELERATING IRON CHELATION FROM SERUM TRANSFERRIN
    WESLEY HARRIS; Fiscal Year: 2004
    ..This is a collaborative project involving faculty with expertise in molecular biology, solution kinetics, organic synthesis, and computational chemistry. ..
  69. Enzyme Mis-Metallation, Consequences and Opportunities
    Anne Frances Miller; Fiscal Year: 2010
    ..abstract_text> ..
  70. Bioactive Compounds from Acylnitroso Cycloadducts
    Marvin Miller; Fiscal Year: 2005
    ..abstract_text> ..
  71. Magnetic Resonance Imaging of Alzheimer's Amyloid Plaque
    JOSEPH PODUSLO; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  72. Novel Derivatization/Functionalization of Natural Produc
    Marvin Miller; Fiscal Year: 2006
    ..3. Broadly test the scaffold and derived libraries of novel compounds using the extensive set of assays in place at the Hans-Knoll Institute for Natural Products Research (HKI). ..
  73. MR and BL Tracking of Stem/Progenitor Cells in the CNS
    Jeff W Bulte; Fiscal Year: 2010
    ..The ultimate goal is to develop ways of reporting on successful cell transplantation without removing any tissue, and to provide neurologists with a means to evaluate stem cell treatment in their patients. ..
  74. MRI MEASUREMENT OF RELATIVE CMR02-- VALIDATION USING PET
    JOSEPH MANDEVILLE; Fiscal Year: 2000
    ..Successful completion of the proposed studies will establish, a new tool for assessment of cerebral functional physiology and preface the application of these techniques to cerebral pathology. ..
  75. NANOSCALE IRON PHASES IN NEURODEGENERATIVE DISEASES
    Jon Dobson; Fiscal Year: 2005
    ..The Pl's combination of skills and experience related to the research proposed here is unique and unavailable in the US. ..
  76. Derivatization/Functionalization of Natural Product(RMI)
    Marvin Miller; Fiscal Year: 2007
    ..3. Broadly test the scaffold and derived libraries of novel compounds using the extensive set of assays in place at the Hans-Knoll Institute for Natural Products Research (HKI). ..
  77. FMRI STUDY OF CNS PHYSIOLOGY DURING COCAINE RESPONSE
    JOSEPH MANDEVILLE; Fiscal Year: 2002
    ..These studies seek to validate the physiological basis of a promising new technology for study of psychoactive drug action in brain and to increase our understanding of the neurobiology of cocaine. ..
  78. DOPAMINERGIC FUNCTION IN RESTLESS LEGS SYNDROME
    Christopher Earley; Fiscal Year: 1999
    ..The authors would also explore relationships between iron and CSF measures of dopaminergic activities, which could provide the basis for entirely new research and treatment approaches to RLS. ..
  79. Hypertension in Hemodialysis Patients
    Rajiv Agarwal; Fiscal Year: 2009
    ..We hypothesize that that volume control can improve BP and antihypertensive therapy can regress left ventricular hypertrophy in long-term hemodialysis patients. ..
  80. HSV-Mediated Chemoradiosensitivity Human Glioma Model
    Constantinos Hadjipanayis; Fiscal Year: 2008
    ..Completion of these goals will serve to transition the PI from a mentored to independent clinician scientist. ..
  81. A LECTIN-CONTRAST AGENT FOR MULTIMODALITY MOLECULAR IMAGING OF TUMOR ANGIOGENESIS
    ARVIND PATHAK; Fiscal Year: 2008
    ..We intend to synthesize and characterize, both T1 and T2 versions of this contrast agent, and employ them to better understand the role of tumor angiogenesis in a human metastatic breast cancer xenograft model. ..
  82. REGULATION OF HEPATIC HEME METABOLISM
    HERBERT BONKOVSKY; Fiscal Year: 1999
    ..abstract_text> ..
  83. Developing a CEST Reporter Gene (RMI)
    JEFF BULTE; Fiscal Year: 2008
    ..To achieve this goal, our aim is to synthesize novel, more efficient CEST reporter genes, and to detect double-labeled LRP/ARP transfected glioma cells and neural stem cells individually in live animals. [unreadable] [unreadable]..
  84. MR-Guided Delivery and Monitoring of Magnetocapsules Immunoprotecting Islet Cells
    JEFF BULTE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..