ferric compounds

Summary

Summary: Inorganic or organic compounds containing trivalent iron.

Top Publications

  1. ncbi Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
    Ajay Kumar Gupta
    Crusade Laboratories Limited, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, Scotland, UK
    Biomaterials 26:3995-4021. 2005
  2. ncbi Iron oxide MR contrast agents for molecular and cellular imaging
    Jeff W M Bulte
    Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    NMR Biomed 17:484-99. 2004
  3. ncbi Ferric carboxymaltose in patients with heart failure and iron deficiency
    Stefan D Anker
    Department of Cardiology, Campus Virchow Klinikum, Charite Universitatsmedizin, Berlin
    N Engl J Med 361:2436-48. 2009
  4. ncbi Extracellular electron transfer via microbial nanowires
    Gemma Reguera
    Department of Microbiology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Nature 435:1098-101. 2005
  5. ncbi Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy
    I Jolanda M de Vries
    Department of Tumor Immunology, Radboud University Nijmegen Medical Center and Nijmegen Center for Molecular Life Sciences, Geert Grooteplein 28, 6500 HB Nijmegen, The Netherlands
    Nat Biotechnol 23:1407-13. 2005
  6. ncbi Recent advances in iron oxide nanocrystal technology for medical imaging
    Claire Corot
    Guerbet Research, BP 57400, 95943 Roissy CDG, France
    Adv Drug Deliv Rev 58:1471-504. 2006
  7. ncbi Ultra-large-scale syntheses of monodisperse nanocrystals
    Jongnam Park
    National Creative Research Center for Oxide Nanocrystalline Materials and School of Chemical Engineering, Seoul National University, Seoul 151 744, Korea
    Nat Mater 3:891-5. 2004
  8. ncbi Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging
    Y X Wang
    Department of Radiology, Erasmus University Medical Center-Dijkzigt, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Eur Radiol 11:2319-31. 2001
  9. ncbi Nanomagnetic sensing of blood plasma protein interactions with iron oxide nanoparticles: impact on macrophage uptake
    Lenaic Lartigue
    Laboratoire Matiere et Systemes Complexes MSC, UMR 7057 CNRS Université Paris Diderot, PRES Sorbonne Paris Cité, 75205 Paris Cedex 13, France
    ACS Nano 6:2665-78. 2012
  10. ncbi Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging
    Jae Hyun Lee
    Department of Chemistry and Nanomedical National Core Research Center, Yonsei University, Seoul 120 749, Korea
    Nat Med 13:95-9. 2007

Research Grants

  1. Functional active-site models of cytochrome c oxidase
    JAMES COLLMAN; Fiscal Year: 2009
  2. Biomimetic Studies of NO-binding Respiratory Chain Hemes
    JAMES COLLMAN; Fiscal Year: 2008
  3. Subharmonic Microbubble Signals for Pressure Estimation
    Flemming Forsberg; Fiscal Year: 2008
  4. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
  5. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
  6. In-Vivo Microscopy for Tissue Engineering
    STANISLAV EMELIANOV; Fiscal Year: 2007
  7. IAPs As Novel Targets for Cancer Therapy
    Lily Yang; Fiscal Year: 2007
  8. Dopamine and Iron in Restless Legs Syndrome
    Christopher Earley; Fiscal Year: 2006
  9. Iron fMRI: Improving Sensitivty and localization
    JOSEPH MANDEVILLE; Fiscal Year: 2006
  10. Cardiovascular Disease Following Hypertensive Pregnancy
    Myles Wolf; Fiscal Year: 2007

Detail Information

Publications316 found, 100 shown here

  1. ncbi Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
    Ajay Kumar Gupta
    Crusade Laboratories Limited, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, Scotland, UK
    Biomaterials 26:3995-4021. 2005
    ..This review discusses the synthetic chemistry, fluid stabilization and surface modification of superparamagnetic iron oxide nanoparticles, as well as their use for above biomedical applications...
  2. ncbi Iron oxide MR contrast agents for molecular and cellular imaging
    Jeff W M Bulte
    Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    NMR Biomed 17:484-99. 2004
    ....
  3. ncbi Ferric carboxymaltose in patients with heart failure and iron deficiency
    Stefan D Anker
    Department of Cardiology, Campus Virchow Klinikum, Charite Universitatsmedizin, Berlin
    N Engl J Med 361:2436-48. 2009
    ....
  4. ncbi Extracellular electron transfer via microbial nanowires
    Gemma Reguera
    Department of Microbiology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Nature 435:1098-101. 2005
    ..Electron transfer through pili indicates possibilities for other unique cell-surface and cell-cell interactions, and for bioengineering of novel conductive materials...
  5. ncbi Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy
    I Jolanda M de Vries
    Department of Tumor Immunology, Radboud University Nijmegen Medical Center and Nijmegen Center for Molecular Life Sciences, Geert Grooteplein 28, 6500 HB Nijmegen, The Netherlands
    Nat Biotechnol 23:1407-13. 2005
    ..MRI cell tracking using iron oxides appears clinically safe and well suited to monitor cellular therapy in humans...
  6. ncbi Recent advances in iron oxide nanocrystal technology for medical imaging
    Claire Corot
    Guerbet Research, BP 57400, 95943 Roissy CDG, France
    Adv Drug Deliv Rev 58:1471-504. 2006
    ..Stem cell migration and immune cell trafficking, as well as targeted iron oxide nanoparticles for molecular imaging studies, are at the stage of proof of concept, mainly in animal models...
  7. ncbi Ultra-large-scale syntheses of monodisperse nanocrystals
    Jongnam Park
    National Creative Research Center for Oxide Nanocrystalline Materials and School of Chemical Engineering, Seoul National University, Seoul 151 744, Korea
    Nat Mater 3:891-5. 2004
    ..The current synthetic procedure is very general and nanocrystals of many transition metal oxides were successfully synthesized using a very similar procedure...
  8. ncbi Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging
    Y X Wang
    Department of Radiology, Erasmus University Medical Center-Dijkzigt, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Eur Radiol 11:2319-31. 2001
    ..Iron oxide particles for bowel contrast are coated with insoluble material, and all iron oxide particles for intravenous injection are biodegradable. Superparamagnetic agents open up an important field for research in MR imaging...
  9. ncbi Nanomagnetic sensing of blood plasma protein interactions with iron oxide nanoparticles: impact on macrophage uptake
    Lenaic Lartigue
    Laboratoire Matiere et Systemes Complexes MSC, UMR 7057 CNRS Université Paris Diderot, PRES Sorbonne Paris Cité, 75205 Paris Cedex 13, France
    ACS Nano 6:2665-78. 2012
    ....
  10. ncbi Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging
    Jae Hyun Lee
    Department of Chemistry and Nanomedical National Core Research Center, Yonsei University, Seoul 120 749, Korea
    Nat Med 13:95-9. 2007
    ..Also, we successfully visualized small tumors implanted in a mouse. Such high-performance, nanotechnology-based molecular probes could enhance the ability to visualize other biological events critical to diagnostics and therapeutics...
  11. ncbi Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
    Mukesh G Harisinghani
    Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 348:2491-9. 2003
    ....
  12. pmc Receptor-targeted nanoparticles for in vivo imaging of breast cancer
    Lily Yang
    Department of Surgery and Winship Cancer Institute, Emory University School of Medicine, C 4088, 1365 C Clifton Road NE, Atlanta, GA 30322, USA
    Clin Cancer Res 15:4722-32. 2009
    ..Cell-surface receptor-targeted magnetic iron oxide nanoparticles provide molecular magnetic resonance imaging contrast agents for improving specificity of the detection of human cancer...
  13. ncbi Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems
    Norased Nasongkla
    Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Nano Lett 6:2427-30. 2006
    ..In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and alpha(v)beta(3)-specific cytotoxic response of these multifunctional polymeric micelles...
  14. pmc Size, charge and concentration dependent uptake of iron oxide particles by non-phagocytic cells
    Daniel L J Thorek
    Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, PA 19104, USA
    Biomaterials 29:3583-90. 2008
    ..Our results show that an unconventional highly cationic particle configuration at 107nm maximized MR contrast of T cells, outperforming the widely utilized USPIO (<50nm)...
  15. pmc In vivo MRI cell tracking: clinical studies
    Jeff W M Bulte
    Russell H Morgan Department of Radiology, Division of MR Research, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    AJR Am J Roentgenol 193:314-25. 2009
    ..The purpose of this review is to describe the principles of MRI cell tracking with superparamagnetic iron oxides and the four clinical trials that have been performed...
  16. ncbi FERGIcor, a randomized controlled trial on ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease
    Rayko Evstatiev
    Department of Medicine 3, Division of Gastroenterology and Hepatology, Christian Doppler Laboratory for Molecular Cancer Chemoprevention, Medical University of Vienna, Vienna, Austria
    Gastroenterology 141:846-853.e1-2. 2011
    ..We compared the efficacy and safety of a novel fixed-dose ferric carboxymaltose regimen (FCM) with individually calculated iron sucrose (IS) doses in patients with inflammatory bowel disease (IBD) and IDA...
  17. ncbi A novel intravenous iron formulation for treatment of anemia in inflammatory bowel disease: the ferric carboxymaltose (FERINJECT) randomized controlled trial
    Stefanie Kulnigg
    Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Am J Gastroenterol 103:1182-92. 2008
    ....
  18. ncbi Maize yellow stripe1 encodes a membrane protein directly involved in Fe(III) uptake
    C Curie
    Biochimie et Physiologie Moleculaire des Plantes, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Université Montpellier 2 et Ecole Nationale Supérieure d Agronomie, France
    Nature 409:346-9. 2001
    ..Cloning of ys1 is an important step in understanding iron uptake in grasses, and has implications for mechanisms controlling iron homeostasis in all plants...
  19. pmc Secretion of flavins by Shewanella species and their role in extracellular electron transfer
    Harald von Canstein
    School of Earth, Atmospheric and Environmental Sciences, The University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom
    Appl Environ Microbiol 74:615-23. 2008
    ..The implications of flavin secretion by Shewanella cells living at redox boundaries, where these mineral phases can be significant electron acceptors for growth, are discussed...
  20. ncbi Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial
    Darlington O Okonko
    Clinical Cardiology, NHLI, Imperial College London, London, United Kingdom
    J Am Coll Cardiol 51:103-12. 2008
    ..We tested the hypothesis that intravenous iron improves exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure (CHF) and iron deficiency...
  21. pmc Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors
    Beata Chertok
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109 1065, USA
    Biomaterials 29:487-96. 2008
    ..Hence, these nanoparticles appear to be a promising vehicle for glioma-targeted drug delivery...
  22. ncbi Toxicity evaluations of superparamagnetic iron oxide nanoparticles: cell "vision" versus physicochemical properties of nanoparticles
    Morteza Mahmoudi
    National Cell Bank, Pasteur Institute of Iran, Tehran, 1316943551 Iran
    ACS Nano 5:7263-76. 2011
    ....
  23. pmc Stimulating the in situ activity of Geobacter species to remove uranium from the groundwater of a uranium-contaminated aquifer
    Robert T Anderson
    Department of Microbiology, University of Massachusetts, Morrill Science Center, Amherst, Massachusetts 01003, USA
    Appl Environ Microbiol 69:5884-91. 2003
    ..These results demonstrate that in situ bioremediation of uranium-contaminated groundwater is feasible but suggest that the strategy should be optimized to better maintain long-term activity of Geobacter species...
  24. ncbi Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications
    Ajay Kumar Gupta
    Laboratory for Nanoparticle Research, Formulation and Development Department, Torrent Research Centre, TPL, Village Bhat, Dist Gandhinagar 382 428, Gujarat, India
    Nanomedicine (Lond) 2:23-39. 2007
    ..We have reviewed the various biomedical applications with some of the most recent uses of magnetic nanoparticles for early detection of cancer, diabetes and atherosclerosis...
  25. ncbi In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals
    Yong Min Huh
    Yonsei Nano Medical Core Research Center, Department of Radiology, Yonsei University, Seoul 120 752, Korea
    J Am Chem Soc 127:12387-91. 2005
    ..Our study finds that high performance in vivo MR diagnosis of cancer is achievable by utilizing improved and multifunctional material properties of iron oxide nanocrystal probes...
  26. pmc Electrically conductive bacterial nanowires produced by Shewanella oneidensis strain MR-1 and other microorganisms
    Yuri A Gorby
    Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Proc Natl Acad Sci U S A 103:11358-63. 2006
    ....
  27. pmc Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
    Xiang Hong Peng
    Department of Medical Oncology Hematology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Int J Nanomedicine 3:311-21. 2008
    ..We review recent advances in the development of targeted IO nanoparticles for tumor imaging and therapy...
  28. ncbi Size-dependent toxicity of metal oxide particles--a comparison between nano- and micrometer size
    Hanna L Karlsson
    Unit for Analytical Toxicology, Department of Biosciences and Nutrition, Novum, Karolinska Insitutet, SE 141 57 Huddinge, Stockholm, Sweden
    Toxicol Lett 188:112-8. 2009
    ..In conclusion, nanoparticles are not always more toxic than micrometer particles, but the high toxicity of CuO nanoparticles shows that the nanolevel gives rise to specific concern...
  29. ncbi Methotrexate-modified superparamagnetic nanoparticles and their intracellular uptake into human cancer cells
    Nathan Kohler
    Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195 2120, USA
    Langmuir 21:8858-64. 2005
    ..The intracellular trafficking model proposed was supported through nanoparticle uptake studies which demonstrated that cells expressing the human folate receptor internalized a higher level of nanoparticles than negative control cells...
  30. pmc Respiration of metal (hydr)oxides by Shewanella and Geobacter: a key role for multihaem c-type cytochromes
    Liang Shi
    Pacific Northwest National Laboratory, Richland, Washington 99354, USA
    Mol Microbiol 65:12-20. 2007
    ..Thus, multihaem c-Cyts play critical roles in S. oneidensis MR-1- and G. sulfurreducens-mediated dissimilatory reduction of solid metal (hydr)oxides by facilitating ET across the bacterial cell envelope...
  31. pmc Induction of inflammation in vascular endothelial cells by metal oxide nanoparticles: effect of particle composition
    Andrea Gojova
    Department of Mechanical and Aeronautical Engineering, University of California, Davis, Davis, California, USA
    Environ Health Perspect 115:403-9. 2007
    ..Ultrafine particles appear to cross the pulmonary epithelial barrier into the bloodstream, raising the possibility of direct contact with the vascular endothelium...
  32. ncbi Superparamagnetic iron oxide nanoparticles change endothelial cell morphology and mechanics via reactive oxygen species formation
    Kivilcim Buyukhatipoglu
    Mechanical Engineering and Mechanics Department, Drexel University, Philadelphia, Pennsylvania 19104, USA
    J Biomed Mater Res A 96:186-95. 2011
    ..If ROS formation is decreased using ROS inhibitors, either as a component of the nanoparticle coating or by systemic administration, higher nanoparticle concentrations might be used with greater efficacy and diminished side effects...
  33. ncbi Cell response to dextran-derivatised iron oxide nanoparticles post internalisation
    Catherine Cecilia Berry
    Centre for Cell Engineering, University of Glasgow, Joseph Black Building, IBLS University Avenue, Glasgow G12 8QQ, UK catherine berry bio gla ac uk
    Biomaterials 25:5405-13. 2004
    ....
  34. ncbi A randomized, controlled trial comparing IV iron sucrose to oral iron in anemic patients with nondialysis-dependent CKD
    David B Van Wyck
    University of Arizona College of Medicine, Tucson, AZ 85704 6128, USA
    Kidney Int 68:2846-56. 2005
    ..Although iron deficiency frequently complicates anemia in patients with nondialysis-dependent CKD (ND-CKD), the comparative treatment value of IV iron infusion and oral iron supplementation has not been established...
  35. pmc Rationale and design of Ferinject assessment in patients with IRon deficiency and chronic Heart Failure (FAIR-HF) study: a randomized, placebo-controlled study of intravenous iron supplementation in patients with and without anaemia
    Stefan D Anker
    Department of Cardiology, Charite, Campus Virchow Klinikum, Augustenburger Platz 1, Berlin D 13353, Germany
    Eur J Heart Fail 11:1084-91. 2009
    ..gov NCT00520780) was designed to determine the effect of i.v. iron repletion therapy using ferric carboxymaltose on self-reported patient global assessment (PGA) and New York Heart Association (NYHA) in patients with CHF and ID...
  36. ncbi Assessing iron oxide nanoparticle toxicity in vitro: current status and future prospects
    Stefaan J H Soenen
    Interdisciplinary Research Centre, Laboratory of BioNanoColloids, K U Leuven Campus Kortrijk, E Sabbelaan 53, B 8500 Kortrijk, Belgium
    Nanomedicine (Lond) 5:1261-75. 2010
    ..e., cell-associated) nanoparticle levels, which could help to advance any progress in this highly important research topic...
  37. ncbi Cytotoxic effects of iron oxide nanoparticles and implications for safety in cell labelling
    Stefaan J H Soenen
    Lab of BioNanoColloids, Interdisciplinary Research Centre, Katholieke Universiteit Leuven, Campus Kortrijk, B8500 Kortrijk, Belgium
    Biomaterials 32:195-205. 2011
    ..These results highlight the importance of in-depth cytotoxic evaluation of cell labelling studies as at non-toxic concentrations, some particles appear to be less suitable for the MR visualization of labelled cells...
  38. ncbi Iron oxide nanoparticles for sustained delivery of anticancer agents
    Tapan K Jain
    Department of Pharmaceutical Sciences, College of Pharmacy, Nebraska Medical Center, Omaha, Nebraska 68198 6025, USA
    Mol Pharm 2:194-205. 2005
    ..This nanoparticle formulation can be used as a universal drug carrier system for systemic administration of water-insoluble drugs while simultaneously allowing magnetic targeting and/or imaging...
  39. ncbi Intracellular uptake of anionic superparamagnetic nanoparticles as a function of their surface coating
    C Wilhelm
    Laboratoire des Milieux Désordonnés et Hétérogènes UMR7603, Universite Pierre et Marie Curie, Tour 13, Case 86, 4 place Jussieu, 75005 Paris, France
    Biomaterials 24:1001-11. 2003
    ..Kinetics of cellular particle uptake for different cell lines are quantitated using two new complementary assays (Magnetophoresis and Electron Spin Resonance)...
  40. ncbi Cell tagging with clinically approved iron oxides: feasibility and effect of lipofection, particle size, and surface coating on labeling efficiency
    Lars Matuszewski
    Department of Clinical Radiology, University Hospital Muenster, Albert Schweitzer Strasse 33, D 48129 Muenster, Germany
    Radiology 235:155-61. 2005
    ..To evaluate the effect of lipofection, particle size, and surface coating on labeling efficiency of mammalian cells with superparamagnetic iron oxides (SPIOs)...
  41. ncbi Intravenous ferric carboxymaltose compared with oral iron in the treatment of postpartum anemia: a randomized controlled trial
    David B Van Wyck
    Arizona Health Sciences Center, University of Arizona College of Medicine, 1821 East Elm Street, Tucson, AZ 85719, USA
    Obstet Gynecol 110:267-78. 2007
    ..To estimate efficacy of rapid, large-dose intravenous (IV) administration of ferric carboxymaltose compared with oral iron therapy in anemic postpartum women...
  42. ncbi In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors
    Moritz F Kircher
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Cancer Res 63:6838-46. 2003
    ..Together, these results demonstrate that CLIO-HD is uniquely suited for quantitative repetitive MRI of adoptively transferred cells and that this approach may be particularly useful for evaluating novel cell-based therapies in vivo...
  43. ncbi Optical and MRI multifunctional nanoprobe for targeting gliomas
    Omid Veiseh
    Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195, USA
    Nano Lett 5:1003-8. 2005
    ..Such a nanoprobe could potentially be used to image resections of glioma brain tumors in real time and to correlate preoperative diagnostic images with intraoperative pathology at cellular-level resolution...
  44. ncbi Iron-oxide labeling and outcome of transplanted mesenchymal stem cells in the infarcted myocardium
    Yoram Amsalem
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer 52621, Israel
    Circulation 116:I38-45. 2007
    ..We sought to determine whether mesenchymal stem cell (MSC) outcome is affected by SPIO labeling in a rat model of myocardial infarction...
  45. pmc MRI-visible micellar nanomedicine for targeted drug delivery to lung cancer cells
    Jagadeesh Setti Guthi
    Department of Pharmacology, Simmons Comprehensive Cancer Center, Department of Internal Medicine, Division of Translational Research, and Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Mol Pharm 7:32-40. 2010
    ..3 +/- 6.4 nM and 73.6 +/- 6.3 nM, respectively; p < 0.005). The integrated diagnostic and therapeutic design of MFM nanomedicine potentially allows for image-guided, target-specific treatment of lung cancer...
  46. ncbi Intravenous iron alone for the treatment of anemia in patients with chronic heart failure
    Aidan P Bolger
    Department of Clinical Cardiology, The Heart Hospital, London, United Kingdom
    J Am Coll Cardiol 48:1225-7. 2006
    ..This study was undertaken to assess the hematologic, clinical, and biochemical response to intravenous iron in patients with chronic heart failure (CHF) and anemia...
  47. ncbi Catechol derivatives-coated Fe3O4 and gamma-Fe2O3 nanoparticles as potential MRI contrast agents
    H Basti
    ITODYS, Université Paris 7 CNRS UMR 7086, 15, rue Jean Antoine de Baif, 75205 Paris Cedex 13, France
    J Colloid Interface Sci 341:248-54. 2010
    ....
  48. ncbi Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency
    Jorge Eduardo Toblli
    Hospital Aleman, Buenos Aires, Argentina
    J Am Coll Cardiol 50:1657-65. 2007
    ....
  49. ncbi Human erythrocytes as nanoparticle carriers for magnetic particle imaging
    D E Markov
    Philips Research Europe, High Tech Campus 4, 5656 AE Eindhoven, The Netherlands
    Phys Med Biol 55:6461-73. 2010
    ..This affects the MPI signal of an erythrocyte-based tracer, compared to bulk. The reduced signal is counterbalanced by a higher in vivo stability of the SPIO-loaded RBCs constructs for MPI applications...
  50. ncbi Biomedical nanoparticles modulate specific CD4+ T cell stimulation by inhibition of antigen processing in dendritic cells
    Fabian Blank
    Department of Clinical Research, Division of Pulmonology, Bern University Hospital, Bern, Switzerland
    Nanotoxicology 5:606-21. 2011
    ..The decreased antigen processing and CD4+ T cell stimulation capability of MDDCs following PVA-SPION treatment suggests that MDDCs may revert to a more functionally immature state following particle exposure...
  51. ncbi Super-paramagnetic iron oxide nanoparticles for use in extrapulmonary tuberculosis diagnosis
    C N Lee
    Department of Pulmonary and Critical Care Medicine, Taipei Medical University Shuang Ho Hospital, Taipei, Taiwan
    Clin Microbiol Infect 18:E149-57. 2012
    ..Mtb sAb-nanoparticles represent a new non-invasive technology for the diagnosis of extrapulmonary Mtb...
  52. pmc SreA-mediated iron regulation in Aspergillus fumigatus
    Markus Schrettl
    Divisions of Molecular Biology Biocenter, Medical University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Mol Microbiol 70:27-43. 2008
    ..As all detrimental effects of sreA disruption are restricted to iron-replete conditions these data underscore that A. fumigatus faces iron-depleted conditions during infection...
  53. ncbi An in vivo multimodal imaging study using MRI and PET of stem cell transplantation after myocardial infarction in rats
    Catherine Chapon
    MRC Clinical Sciences Centre, Imperial College London, UK
    Mol Imaging Biol 11:31-8. 2009
    ....
  54. pmc Facilitated monocyte-macrophage uptake and tissue distribution of superparmagnetic iron-oxide nanoparticles
    Arnaud Beduneau
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 4:e4343. 2009
    ....
  55. ncbi Respiratory interactions of soil bacteria with (semi)conductive iron-oxide minerals
    Souichiro Kato
    Hashimoto Light Energy Conversion Project, ERATO, JST, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    Environ Microbiol 12:3114-23. 2010
    ..We suggest that subsurface-clade Geobacter species preferentially thrive in soil by utilizing (semi)conductive iron oxides for their respiration...
  56. pmc Antibody conjugated magnetic iron oxide nanoparticles for cancer cell separation in fresh whole blood
    Hengyi Xu
    State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, PR China
    Biomaterials 32:9758-65. 2011
    ..This research holds promise for efficient separation of circulating cancer cells in fresh whole blood...
  57. ncbi Cellular distribution and degradation of cobalt ferrite nanoparticles in Balb/3T3 mouse fibroblasts
    Patrick Marmorato
    European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Ispra Va, Italy
    Toxicol Lett 207:128-36. 2011
    ....
  58. ncbi (Carboxymethyl)chitosan-modified superparamagnetic iron oxide nanoparticles for magnetic resonance imaging of stem cells
    Zhilong Shi
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent Ridge, Singapore, Singapore
    ACS Appl Mater Interfaces 1:328-35. 2009
    ..05 mg/mL of CMCS-SPIONs for 24 h was estimated to be about 40 cells. The results from this study indicate that the biocompatible CMCS-SPIONs show promise for use with MRI in visualizing hMSCs...
  59. ncbi Magnetic micelles as a potential platform for dual targeted drug delivery in cancer therapy
    Chi Huang
    School of Materials Science and Engineering, Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, PR China
    Int J Pharm 429:113-22. 2012
    ....
  60. ncbi Controllable labelling of stem cells with a novel superparamagnetic iron oxide-loaded cationic nanovesicle for MR imaging
    Ruo Mi Guo
    Department of Radiology, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, No 107 Yanjiang Road West, Guangzhou, 510120, Guangdong, China
    Eur Radiol 22:2328-37. 2012
    ..To investigate the feasibility of highly efficient and controllable stem cell labelling for cellular MRI...
  61. ncbi Cooperative organization in iron oxide multi-core nanoparticles potentiates their efficiency as heating mediators and MRI contrast agents
    Lenaic Lartigue
    Laboratoire Matières et Systèmes Complexes, UMR 7057 CNRS Université Paris Diderot, 10 rue Alice Domon et Leonie Duquet, 75013 Paris, France
    ACS Nano 6:10935-49. 2012
    ....
  62. ncbi Methanogenesis facilitated by electric syntrophy via (semi)conductive iron-oxide minerals
    Souichiro Kato
    Hashimoto Light Energy Conversion Project, ERATO, JST, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Environ Microbiol 14:1646-54. 2012
    ..Given the ubiquity of conductive minerals in nature, such energetic interactions may occur widely in soil and sediments and can be used to develop efficient bioenergy processes...
  63. ncbi Top-down fabrication of α-Fe2O3 single-crystal nanodiscs and microparticles with tunable porosity for largely improved lithium storage properties
    Jun Song Chen
    School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, China
    J Am Chem Soc 132:13162-4. 2010
    ....
  64. pmc Specific targeting of brain tumors with an optical/magnetic resonance imaging nanoprobe across the blood-brain barrier
    Omid Veiseh
    Departments of Materials Science and Engineering, University of Washington, Seattle, Washington 99195, USA
    Cancer Res 69:6200-7. 2009
    ....
  65. ncbi Impact of magnetic labeling on human and mouse stem cells and their long-term magnetic resonance tracking in a rat model of Parkinson disease
    Albrecht Stroh
    Institute of Neuroscience, Technical University Munich, Munich, Germany
    Mol Imaging 8:166-78. 2009
    ..Our study strongly suggests that molecular MRI approaches must be carefully tailored to the respective cell population to exert minimal physiologic impact, ensuring the feasibility of this imaging approach for clinical applications...
  66. ncbi Thermally cross-linked superparamagnetic iron oxide nanoparticles: synthesis and application as a dual imaging probe for cancer in vivo
    Haerim Lee
    Research Center for Biomolecular Nanotechnology, Department of Life Science, GIST, Buk Gu, Gwangju, Republic of Korea
    J Am Chem Soc 129:12739-45. 2007
    ..5 TCL-SPION within the tumor. It is noteworthy that, despite the fact that TCL-SPION does not bear any targeting ligands on its surface, it was highly effective for tumor detection in vivo by dual imaging...
  67. ncbi Iron oxide-based nanostructures for MRI and magnetic hyperthermia
    Ingrid Hilger
    Institute of Diagnostic and Interventional Radiology I, Department of Experimental Radiology, University Hospital Jena, Friedrich Schiller Universitat Jena, Erlanger Allee 101, 07747 Jena, Germany
    Nanomedicine (Lond) 7:1443-59. 2012
    ..Nevertheless, such approaches have been challenging due to the necessity of the adaptation of at least partially counteracting parameters between the different modalities, which will be analyzed in this review...
  68. ncbi Superparamagnetic nanoparticle-inclusion microbubbles for ultrasound contrast agents
    Fang Yang
    State Key Laboratory of Bioelectronics, Jiangsu Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, Peoples Republic of China
    Phys Med Biol 53:6129-41. 2008
    ....
  69. ncbi Iron oxide nanoparticle-containing microbubble composites as contrast agents for MR and ultrasound dual-modality imaging
    Zhe Liu
    Department of Experimental Molecular Imaging ExMI, Helmholtz Institute for Biomedical Engineering, Medical Faculty, RWTH Aachen University, Aachen 52074, Germany
    Biomaterials 32:6155-63. 2011
    ....
  70. pmc SidL, an Aspergillus fumigatus transacetylase involved in biosynthesis of the siderophores ferricrocin and hydroxyferricrocin
    Michael Blatzer
    Division of Molecular Biology, Biocenter, Fritz Pregl Str 3, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Appl Environ Microbiol 77:4959-66. 2011
    ..Moreover, this study revealed the unexpected complexity of siderophore biosynthesis, indicating the existence of an additional, iron-repressed N(5)-hydroxyornithine-acetylase...
  71. pmc In vivo tracking of mesenchymal stem cells labeled with a novel chitosan-coated superparamagnetic iron oxide nanoparticles using 3.0T MRI
    Alavala Matta Reddy
    Department of Radiology, Chung Ang University College of Medicine, Seoul, Korea
    J Korean Med Sci 25:211-9. 2010
    ..The migration of cells was also confirmed by histological studies. The novel chitosan-SPIO enables to label and track MSC for in vivo MRI without cellular alteration...
  72. ncbi Interactions between sub-10-nm iron and cerium oxide nanoparticles and 3T3 fibroblasts: the role of the coating and aggregation state
    M Safi
    Matiere et Systemes Complexes, UMR 7057 CNRS, Université Denis Diderot Paris VII, Batiment Condorcet, 10 rue Alice Domon et Leonie Duquet, Paris, France
    Nanotechnology 21:145103. 2010
    ..In conclusion, we show that the uptake of nanomaterials by living cells depends on the coating of the particles and on its ability to preserve the colloidal nature of the dispersions...
  73. pmc Formulation of novel lipid-coated magnetic nanoparticles as the probe for in vivo imaging
    Huey Chung Huang
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Biomed Sci 16:86. 2009
    ..Here, we formulated new cationic lipid nanoparticles containing SPIOs feasible for in vivo imaging...
  74. ncbi Microbial nanowires: a new paradigm for biological electron transfer and bioelectronics
    Nikhil S Malvankar
    Department of Microbiology, University of Massachusetts, Amherst, 203, Morrill Science Center IVN, 639 North Pleasant Street, Amherst, MA 01003, USA
    ChemSusChem 5:1039-46. 2012
    ....
  75. ncbi FMN-coated fluorescent iron oxide nanoparticles for RCP-mediated targeting and labeling of metabolically active cancer and endothelial cells
    Jabadurai Jayapaul
    Department of Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany
    Biomaterials 32:5863-71. 2011
    ..This was shown for FLUSPIO, which due to their high T(2)-relaxivity, are favorably suited for MR cell tracking experiments and cancer detection in vivo...
  76. ncbi Uptake and biological responses to nano-Fe versus soluble FeCl3 in excised mussel gills
    Eniko Kadar
    Plymouth Marine Laboratory, Prospect Place, The Hoe, Plymouth PL1 3DH, UK
    Anal Bioanal Chem 396:657-66. 2010
    ..However, with the use of nano-Fe as a food additive, clearly longer-term in vivo studies are warranted...
  77. ncbi Intravenous iron administration in a short-stay hospital setting
    George Peebles
    Department of Renal Medicine, Sunderland Royal Hospital, Sunderland
    Nurs Stand 22:35-41. 2008
    ..In this arena the role of intravenous (IV) iron is well established. This article describes how IV iron may be given in total doses in a short-stay hospital setting...
  78. pmc EGFRvIII antibody-conjugated iron oxide nanoparticles for magnetic resonance imaging-guided convection-enhanced delivery and targeted therapy of glioblastoma
    Costas G Hadjipanayis
    Brain Tumor Nanotechnology Laboratory, Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 70:6303-12. 2010
    ....
  79. ncbi An in vitro study of bare and poly(ethylene glycol)-co-fumarate-coated superparamagnetic iron oxide nanoparticles: a new toxicity identification procedure
    Morteza Mahmoudi
    Institute for Nanoscience and Nanotechnology, Sharif University of Technology, Tehran, Iran
    Nanotechnology 20:225104. 2009
    ..It is shown that a more reliable way of identifying cytotoxicity for in vitro assessments is to use particles with saturated surfaces via interactions with DMEM before usage...
  80. ncbi Magnetic core/shell Fe3O4/Au and Fe3O4/Au/Ag nanoparticles with tunable plasmonic properties
    Zhichuan Xu
    Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA
    J Am Chem Soc 129:8698-9. 2007
  81. ncbi Magnetic resonance imaging of transplanted mouse islets labeled with chitosan-coated superparamagnetic iron oxide nanoparticles
    J H Juang
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung University and Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Transplant Proc 42:2104-8. 2010
    ..Our results indicate that isolated mouse islets labeled with CSPIO nanoparticles can be effectively and safely imaged by using MRI as long as 18 weeks after transplantation...
  82. ncbi Clinical hyperthermia of prostate cancer using magnetic nanoparticles: presentation of a new interstitial technique
    M Johannsen
    Department of Urology, Charite Campus Mitte, Schumannstr 20 21, 10117 Berlin, Germany
    Int J Hyperthermia 21:637-47. 2005
    ..To the authors' knowledge, this is the first report on clinical application of interstitial hyperthermia using magnetic nanoparticles in the treatment of human cancer...
  83. pmc Lithotrophic iron-oxidizing bacteria produce organic stalks to control mineral growth: implications for biosignature formation
    Clara S Chan
    Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, Woods Hole, MA, USA
    ISME J 5:717-27. 2011
    ..We suggest that stalk-like morphologies observed in modern and ancient samples may be correlated confidently with the Fe-oxidizing metabolism as a robust biosignature...
  84. ncbi Large-dose intravenous ferric carboxymaltose injection for iron deficiency anemia in heavy uterine bleeding: a randomized, controlled trial
    David B Van Wyck
    DaVita, Inc, Tucson, Arizona, USA
    Transfusion 49:2719-28. 2009
    ..The objective was to evaluate efficacy and safety of rapid, large-dose intravenous (IV) administration of ferric carboxymaltose compared to oral iron in correcting iron deficiency anemia due to heavy uterine bleeding...
  85. ncbi Oxidative stress mediated apoptosis induced by nickel ferrite nanoparticles in cultured A549 cells
    Maqusood Ahamed
    King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia
    Toxicology 283:101-8. 2011
    ..To the best of our knowledge this is the first report showing that nickel ferrite nanoparticles induced apoptosis in A549 cells through ROS generation and oxidative stress via p53, survivin, bax/bcl-2 and caspase pathways...
  86. ncbi MR molecular imaging of the Her-2/neu receptor in breast cancer cells using targeted iron oxide nanoparticles
    Dmitri Artemov
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Magn Reson Med 49:403-8. 2003
    ..In these experiments, iron oxide nanoparticles were attached to the cell surface and were not internalized into the cells, which is a major advantage for in vivo applications of the method...
  87. ncbi From iron oxide nanoparticles towards advanced iron-based inorganic materials designed for biomedical applications
    Albert Figuerola
    Istituto Italiano di Tecnologia, 16163 Genova, Italy
    Pharmacol Res 62:126-43. 2010
    ..In our discussion we will focus on those works that have provided a sound proof of concept on the potential of the various systems as diagnostic and therapeutic agents...
  88. ncbi Glial cell line-derived neurotrophic factor-conjugated nanoparticles suppress acquisition of cocaine self-administration in rats
    T Green-Sadan
    Neuropharmacology Laboratory, Faculty of Life Sciences and the Leslie and Susan Gonda Goldshmied Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, Israel
    Exp Neurol 194:97-105. 2005
    ..These findings suggest that GDNF-conjugated nanoparticles may serve as a novel potential treatment for drug addiction...
  89. ncbi Ferric carboxymaltose: a review of its use in iron-deficiency anaemia
    Katherine A Lyseng-Williamson
    Wolters Kluwer Health mid R Adis, Auckland, New Zealand, an editorial office of Wolters Kluwer Health, Philadelphia, Pennsylvania, USA
    Drugs 69:739-56. 2009
    ..In patients with chronic kidney disease undergoing haemodialysis, a lower proportion of ferric carboxymaltose than iron sucrose recipients experienced at least one drug-related adverse event...
  90. ncbi Iron metabolism in pathogenic bacteria
    C Ratledge
    Department of Biological Sciences, University of Hull, Hull HU6 7RX
    Annu Rev Microbiol 54:881-941. 2000
    ..In this way, the biochemistry of the bacterial cell can accommodate the challenges from the host. Agents that interfere with bacterial iron metabolism may prove extremely valuable for chemotherapy of diseases...
  91. ncbi Application of the static dephasing regime theory to superparamagnetic iron-oxide loaded cells
    Chris V Bowen
    Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    Magn Reson Med 48:52-61. 2002
    ..This work is an important first step in quantifying cellular iron content and ultimately mapping the density of a targeted cell population...
  92. pmc MR tracking of transplanted cells with "positive contrast" using manganese oxide nanoparticles
    Assaf A Gilad
    Russell H Morgan Department of Radiology, Division of MR Research, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Magn Reson Med 60:1-7. 2008
    ..Simultaneous imaging of both transplants with opposite contrast offers a method for MR "double labeling" of different cell populations...
  93. ncbi Sodium ferric gluconate complex in hemodialysis patients: adverse reactions compared to placebo and iron dextran
    Beckie Michael
    Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Kidney Int 61:1830-9. 2002
    ..S. under FDA's priority drug review. This Phase IV study was designed to evaluate the safety of a single dose of intravenous SFGC as compared to placebo and a historical iron dextran control...
  94. doi Drug-loaded superparamagnetic iron oxide nanoparticles for combined cancer imaging and therapy in vivo
    Mi Kyung Yu
    Research Center for Biomolecular Nanotechnology, Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryong dong, Buk Gu, Gwangju 500 712, South Korea
    Angew Chem Int Ed Engl 47:5362-5. 2008
  95. ncbi Intravenous iron without erythropoietin for the treatment of iron deficiency anemia in patients with moderate to severe congestive heart failure and chronic kidney insufficiency
    Rustam I Usmanov
    Republican Research Center of Emergency Medicine of Uzbekistan, Tashkent, Uzbekistan
    J Nephrol 21:236-42. 2008
    ..The purpose of this study was to assess the effect of intravenous (i.v.) iron on the anemia of CHF patients and on cardiac remodeling, New York Heart Association (NYHA) classification and renal function...
  96. ncbi Ferric carboxymaltose injection in the treatment of postpartum iron deficiency anemia: a randomized controlled clinical trial
    Melvin H Seid
    Lyndhurst Gynecologic Associates, Winston Salem, NC 27103, USA
    Am J Obstet Gynecol 199:435.e1-7. 2008
    ..The objective of the study was to evaluate the efficacy, safety, and tolerability of intravenous ferric carboxymaltose, compared with oral ferrous sulfate in women with postpartum anemia...
  97. pmc Reversal of multidrug resistance by magnetic Fe3O4 nanoparticle copolymerizating daunorubicin and 5-bromotetrandrine in xenograft nude-mice
    Baoan Chen
    Department of Hematology, Zhongda Hospital, Southeast University, Nanjing, 210009, PR China
    Int J Nanomedicine 4:73-8. 2009
    ..It is concluded that 5-BrTet and MNP-Fe(3)O(4) combined with DNR had a significant tumor-suppressing effect on a MDR leukemia cells xenograft model...
  98. ncbi Superparamagnetic iron oxide nanoparticle-embedded encapsulated microbubbles as dual contrast agents of magnetic resonance and ultrasound imaging
    Fang Yang
    Jiangsu Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
    Biomaterials 30:3882-90. 2009
    ..Therefore, the proposed SPIO nanoparticle-embedded EMBs potentially can become effective MR susceptibility contrast agents while also can be good US contrast agents...
  99. ncbi Effect of surface charge and agglomerate degree of magnetic iron oxide nanoparticles on KB cellular uptake in vitro
    Yuqing Ge
    State Key Laboratory of Bioelectronics, Jiangsu Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, PR China
    Colloids Surf B Biointerfaces 73:294-301. 2009
    ..5T clinical MR imager. The finding of this study will have implications in the chemical design of nanomaterials for biomedical applications...
  100. pmc Evaluation of iron oxide nanoparticle biocompatibility
    Amel Hanini
    Interface Traitement, Organisation et Dynamique des Systemes, Universite Paris 7, Paris, France
    Int J Nanomedicine 6:787-94. 2011
    ..In conclusion, γ-Fe(2)O(3) could exhibit harmful properties and therefore surface coating, cellular targeting, and local exposure should be considered before developing clinical applications...
  101. ncbi Dual drug loaded superparamagnetic iron oxide nanoparticles for targeted cancer therapy
    Fahima Dilnawaz
    Laboratory of Nanomedicine, Institute of Life Sciences, Nalco Square, Chandrasekharpur, Bhubaneswar 751023, Orissa, India
    Biomaterials 31:3694-706. 2010
    ..The IC(50) doses revealed potential antiproliferative effect in MCF-7. Therefore, antibody conjugated GMO-MNPs could be used as potential drug carrier for the active therapeutic aspects in cancer therapy...

Research Grants43

  1. Functional active-site models of cytochrome c oxidase
    JAMES COLLMAN; Fiscal Year: 2009
    ..The role that the copper ion (CuB) and a phenolic group, in the amino acid tyrosine (Tyr244) play in the catalytic function of CcO are of particular interest. ..
  2. Biomimetic Studies of NO-binding Respiratory Chain Hemes
    JAMES COLLMAN; Fiscal Year: 2008
    ..An emphasis will be placed on kinetic and mechanistic studies to elucidate the putitive reaction pathways of CcO and NOR. ..
  3. Subharmonic Microbubble Signals for Pressure Estimation
    Flemming Forsberg; Fiscal Year: 2008
    ..This will allow potentially life-threatening diseases, such as increased pressure in the liver, to be diagnosed early. [unreadable] [unreadable] [unreadable]..
  4. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  5. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  6. In-Vivo Microscopy for Tissue Engineering
    STANISLAV EMELIANOV; Fiscal Year: 2007
    ..The long-range goal of our research program is to develop a combined ultrasound-based microscopy system for tissue engineers. [unreadable] [unreadable] [unreadable]..
  7. IAPs As Novel Targets for Cancer Therapy
    Lily Yang; Fiscal Year: 2007
    ..Results from this research should allow us to determine if IAPs are novel molecular targets for the development of cancer-specific therapeutic approaches. ..
  8. Dopamine and Iron in Restless Legs Syndrome
    Christopher Earley; Fiscal Year: 2006
    ..Using CSF and MRI measurements of iron will assess the CNS iron status. RLS severity will be based on subjective (rating scale and diary) and objective (PSG) measurements. ..
  9. Iron fMRI: Improving Sensitivty and localization
    JOSEPH MANDEVILLE; Fiscal Year: 2006
    ..abstract_text> ..
  10. Cardiovascular Disease Following Hypertensive Pregnancy
    Myles Wolf; Fiscal Year: 2007
    ..They believe the results will provide critical insight into mechanisms of CVD in women and potentially suggest means to alter their CVD risk. [unreadable] [unreadable]..
  11. Intravascular Photoacoustic Imaging of Atherosclerotic Plaques
    STANISLAV EMELIANOV; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  12. Low-Cost Digital Imaging System for Evaluating Thrombosis
    Brian Cooley; Fiscal Year: 2008
    ..This imaging methodology may have a capacity for future adaptation to clinical thrombosis imaging. [unreadable] [unreadable] [unreadable]..
  13. Automated Alignment of MRI Rodent Brain to Sterotaxic Atlases
    JOSEPH MANDEVILLE; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  14. Desferrithiocin Analogue Actinide Decorporation Agents
    RAYMOND BERGERON; Fiscal Year: 2008
    ..abstract_text> ..
  15. Novel Mechanism of Uranium Reduction Via Microbial Nanowires
    Gemma Reguera; Fiscal Year: 2011
    ....
  16. The biology of gastrin-ferric ion complexes
    GRAHAM BALDWIN; Fiscal Year: 2009
    ..Recognition that metal ions are essential for the biological activity of NAGs may permit the development of novel therapies for colon cancer. ..
  17. Combined Intravascular Ultrasound and Photoacoustic Imaging of Atherosclerosis
    Stanislav Y Emelianov; Fiscal Year: 2010
    ..At the conclusion of this study and in cooperation with industrial partners, we will be ready to build the clinical IVUS/IVPA imaging system demonstrating the application of developed technology in interventional cardiology. ..
  18. fMRI and neuronal activity in awake behavior
    JOSEPH MANDEVILLE; Fiscal Year: 2006
    ..Finally, we will test the neural-fMRI relationship in a higher-order region of visual cortex which appears to be specialized for processing faces and other visual objects. ..
  19. Effect of Age on Vein Graft Neointimal Formation
    Brian Cooley; Fiscal Year: 2003
    ..Furthermore, the establishment of an age-associated model of vein grafting will permit age-specific evaluation of new therapeutic avenues for inhibiting neointimal formation. ..
  20. MRI MEASUREMENT OF RELATIVE CMR02-- VALIDATION USING PET
    JOSEPH MANDEVILLE; Fiscal Year: 2002
    ..Successful completion of the proposed studies will establish, a new tool for assessment of cerebral functional physiology and preface the application of these techniques to cerebral pathology. ..
  21. MRI MEASUREMENT OF RELATIVE CMR02-- VALIDATION USING PET
    JOSEPH MANDEVILLE; Fiscal Year: 2001
    ..Successful completion of the proposed studies will establish, a new tool for assessment of cerebral functional physiology and preface the application of these techniques to cerebral pathology. ..
  22. THERAPEUTIC BENEFIT OF HYDROGEN PEROXIDE REMOVAL IN FALS
    JOSEPH PODUSLO; Fiscal Year: 2003
    ..This grant proposal, therefore, will further test whether this hypothesis-driven therapy is beneficial in the treatment of FALS transgenic mice, which will have direct implications for the treatment of both familial and sporadic ALS. ..
  23. DETERMINING THE GENETICS OF RESTLESS LEGS SYNDROME
    Christopher Earley; Fiscal Year: 2003
    ....
  24. IRON CHELATORS PREDICATED ON DESFERRITHIOCIN
    RAYMOND BERGERON; Fiscal Year: 2004
    ....
  25. Response to Iron Treatment for Restless Leg Syndrome
    Christopher Earley; Fiscal Year: 2004
    ..An expected finding that IV iron reduces the brain iron insufficiency and dramatically reduces the RLS symptoms strongly supports our model of RLS caused by brain iron insufficiency. ..
  26. MR IMAGING OF MYOCARDIAL VIABILITY AFTER ISCHEMIC INSULT
    Dara Kraitchman; Fiscal Year: 2004
    ..abstract_text> ..
  27. DRUGS AND DELIVERY SYSTEMS FOR OPPORTUNISTIC INFECTIONS
    Marvin Miller; Fiscal Year: 2002
    ....
  28. Bioactive Compounds from Acylnitroso Cycloadducts
    Marvin Miller; Fiscal Year: 2006
    ..abstract_text> ..
  29. Lung tumor detection using biomagnetic imaging
    LAUREL SILLERUD; Fiscal Year: 2004
    ..abstract_text> ..
  30. Matrix metalloproteinases as biomarkers of neurodegeneration
    Veronica Shubayev; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  31. DOPAMINERGIC FUNCTION IN RESTLESS LEGS SYNDROME
    Christopher Earley; Fiscal Year: 2001
    ..The authors would also explore relationships between iron and CSF measures of dopaminergic activities, which could provide the basis for entirely new research and treatment approaches to RLS. ..
  32. Enzyme Mis-Metallation, Consequences and Opportunities
    Anne Frances Miller; Fiscal Year: 2010
    ..abstract_text> ..
  33. Magnetic Resonance Imaging of Alzheimer's Amyloid Plaque
    JOSEPH PODUSLO; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  34. ACCELERATING IRON CHELATION FROM SERUM TRANSFERRIN
    WESLEY HARRIS; Fiscal Year: 2004
    ..This is a collaborative project involving faculty with expertise in molecular biology, solution kinetics, organic synthesis, and computational chemistry. ..
  35. NANOSCALE IRON PHASES IN NEURODEGENERATIVE DISEASES
    Jon Dobson; Fiscal Year: 2005
    ..The Pl's combination of skills and experience related to the research proposed here is unique and unavailable in the US. ..
  36. Derivatization/Functionalization of Natural Product(RMI)
    Marvin Miller; Fiscal Year: 2007
    ..3. Broadly test the scaffold and derived libraries of novel compounds using the extensive set of assays in place at the Hans-Knoll Institute for Natural Products Research (HKI). ..
  37. FMRI STUDY OF CNS PHYSIOLOGY DURING COCAINE RESPONSE
    JOSEPH MANDEVILLE; Fiscal Year: 2002
    ..These studies seek to validate the physiological basis of a promising new technology for study of psychoactive drug action in brain and to increase our understanding of the neurobiology of cocaine. ..
  38. REGULATION OF HEPATIC HEME METABOLISM
    HERBERT BONKOVSKY; Fiscal Year: 2009
    ..the molecular mechanisms that mediate heme regulation of ALAS-1 and HO-1 are similar in avian, human, and murine hepatocytes in culture or in intact organisms. ..
  39. MR-Guided Delivery and Monitoring of Magnetocapsules Immunoprotecting Islet Cells
    JEFF BULTE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  40. ASN Workshop "In Vivo MR Tracking of Stem Cells in the CNS" (R13)
    JEFF BULTE; Fiscal Year: 2005
    ..The outcome of the workshop will be published in Experimental Neurology and available for the scientific community at large. ..
  41. MR-Guided Delivery and Monitoring of Magnetocapsules Immunoprotecting Islet Cells
    JEFF BULTE; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  42. Nitroreductase: Determinants of Flavin Enzyme Activity
    Anne Frances Miller; Fiscal Year: 2004
    ..These tools will have widespread applicability to flavoproteins. ..
  43. Developing a CEST Reporter Gene (RMI)
    JEFF BULTE; Fiscal Year: 2008
    ..To achieve this goal, our aim is to synthesize novel, more efficient CEST reporter genes, and to detect double-labeled LRP/ARP transfected glioma cells and neural stem cells individually in live animals. [unreadable] [unreadable]..