Summary: An element with atomic symbol O, atomic number 8, and atomic weight 16. It is the most abundant element on earth and essential for respiration.

Top Publications

  1. pmc A default mode of brain function
    M E Raichle
    Mallinckrodt Institute of Radiology and Departments of Neurology and Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:676-82. 2001
  2. doi Spreading dead zones and consequences for marine ecosystems
    Robert J Diaz
    Virginia Institute of Marine Science, College of William and Mary, Gloucester Point, VA 23062, USA
    Science 321:926-9. 2008
  3. doi Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine
    Barbara van Loon
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    DNA Repair (Amst) 9:604-16. 2010
  4. doi Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway
    William G Kaelin
    Howard Hughes Medical Institute, Boston, MA 02115, USA
    Mol Cell 30:393-402. 2008
  5. ncbi Hypoxia signalling in cancer and approaches to enforce tumour regression
    Jacques Pouyssegur
    Institute of Signalling, Developmental Biology and Cancer Research, CNRS UMR 6543, University of Nice, Centre Antoine Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    Nature 441:437-43. 2006
  6. ncbi Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
    P Jaakkola
    The Henry Wellcome Building of Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Science 292:468-72. 2001
  7. pmc Antioxidants, oxidative damage and oxygen deprivation stress: a review
    Olga Blokhina
    Department of Biosciences, Division of Plant Physiology, Viikki Biocenter, FIN 00014 Helsinki University, Finland
    Ann Bot 91:179-94. 2003
  8. ncbi Oxygen sensing by HIF hydroxylases
    Christopher J Schofield
    The Oxford Centre for Molecular Sciences and The Dyson Perrins Laboratory, Department of Chemistry, South Parks Road, Oxford OX1 3QY, UK
    Nat Rev Mol Cell Biol 5:343-54. 2004
  9. ncbi Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1
    G L Semenza
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Annu Rev Cell Dev Biol 15:551-78. 1999
  10. pmc Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    G L Wang
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
    Proc Natl Acad Sci U S A 92:5510-4. 1995

Detail Information

Publications320 found, 100 shown here

  1. pmc A default mode of brain function
    M E Raichle
    Mallinckrodt Institute of Radiology and Departments of Neurology and Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:676-82. 2001
    ..Despite this prediction we identify a baseline state of the normal adult human brain in terms of the brain oxygen extraction fraction or OEF...
  2. doi Spreading dead zones and consequences for marine ecosystems
    Robert J Diaz
    Virginia Institute of Marine Science, College of William and Mary, Gloucester Point, VA 23062, USA
    Science 321:926-9. 2008
    ..accumulation of particulate organic matter, which encourages microbial activity and the consumption of dissolved oxygen in bottom waters...
  3. doi Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine
    Barbara van Loon
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    DNA Repair (Amst) 9:604-16. 2010
    ..Various environmental and endogenous agents, such as reactive oxygen species (ROS), can modify the structural properties of DNA bases and thus damage the DNA...
  4. doi Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway
    William G Kaelin
    Howard Hughes Medical Institute, Boston, MA 02115, USA
    Mol Cell 30:393-402. 2008
    HIF plays a central role in the transcriptional response to changes in oxygen availability. The PHD family of oxygen-dependent prolyl hydroxylases plays a pivotal role in regulating HIF stability...
  5. ncbi Hypoxia signalling in cancer and approaches to enforce tumour regression
    Jacques Pouyssegur
    Institute of Signalling, Developmental Biology and Cancer Research, CNRS UMR 6543, University of Nice, Centre Antoine Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    Nature 441:437-43. 2006
    ..b>Oxygen limitation is central in controlling neovascularization, glucose metabolism, survival and tumour spread...
  6. ncbi Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
    P Jaakkola
    The Henry Wellcome Building of Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Science 292:468-72. 2001
    ..factor (HIF) is a transcriptional complex that plays a central role in the regulation of gene expression by oxygen. In oxygenated and iron replete cells, HIF-alpha subunits are rapidly destroyed by a mechanism that involves ..
  7. pmc Antioxidants, oxidative damage and oxygen deprivation stress: a review
    Olga Blokhina
    Department of Biosciences, Division of Plant Physiology, Viikki Biocenter, FIN 00014 Helsinki University, Finland
    Ann Bot 91:179-94. 2003
    ..of environmental factors including UV stress, pathogen invasion (hypersensitive reaction), herbicide action and oxygen shortage...
  8. ncbi Oxygen sensing by HIF hydroxylases
    Christopher J Schofield
    The Oxford Centre for Molecular Sciences and The Dyson Perrins Laboratory, Department of Chemistry, South Parks Road, Oxford OX1 3QY, UK
    Nat Rev Mol Cell Biol 5:343-54. 2004
  9. ncbi Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1
    G L Semenza
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Annu Rev Cell Dev Biol 15:551-78. 1999
    ..HIF-1 thus appears to function as a master regulator of O2 homeostasis that plays essential roles in cellular and systemic physiology, development, and pathophysiology...
  10. pmc Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    G L Wang
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
    Proc Natl Acad Sci U S A 92:5510-4. 1995
  11. ncbi Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules
    Benjamin J Moeller
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 5:429-41. 2004
    ..Following radiotherapy, tumor reoxygenation leads to: (1) nuclear accumulation of HIF-1 in response to reactive oxygen, and (2) enhanced translation of HIF-1-regulated transcripts secondary to stress granule depolymerization...
  12. ncbi Hypoxia--a key regulatory factor in tumour growth
    Adrian L Harris
    Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Nat Rev Cancer 2:38-47. 2002
    ..Many elements of the hypoxia-response pathway are therefore good candidates for therapeutic targeting...
  13. pmc A practical guide to single-molecule FRET
    Rahul Roy
    Department of Physics, University of Illinois at Urbana Champaign, 1110 West Green Street, Urbana, Illinois 61801, USA
    Nat Methods 5:507-16. 2008
    ..We also describe how a smFRET-capable instrument can be built at a reasonable cost with off-the-shelf components and operated reliably using well-established protocols and freely available software...
  14. doi Alloys of platinum and early transition metals as oxygen reduction electrocatalysts
    J Greeley
    Center for Atomic Scale Materials Design, Department of Physics, Technical University of Denmark, Lyngby, Denmark
    Nat Chem 1:552-6. 2009
    ..will require significant reductions in the amount of expensive Pt contained within their cathodes, which drive the oxygen reduction reaction (ORR)...
  15. ncbi Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
    Robert D Guzy
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Cell Metab 1:401-8. 2005
    Multicellular organisms initiate adaptive responses when oxygen (O(2)) availability decreases, but the underlying mechanism of O(2) sensing remains elusive...
  16. pmc Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis
    Heui Dong Park
    Department of Pathobiology, University of Washington, Seattle, WA 98195, USA
    Mol Microbiol 48:833-43. 2003
    ..Together, these results demonstrate that Rv3133c/DosR is a transcription factor of the two-component response regulator class, and that it is the primary mediator of a hypoxic signal within M. tuberculosis...
  17. ncbi Why do cancers have high aerobic glycolysis?
    Robert A Gatenby
    Department of Radiology, University of Arizona, Tucson, Arizona 85721, USA
    Nat Rev Cancer 4:891-9. 2004
    ..Subsequent cell populations with upregulated glycolysis and acid resistance have a powerful growth advantage, which promotes unconstrained proliferation and invasion...
  18. pmc Mitochondrial formation of reactive oxygen species
    Julio F Turrens
    Department of Biomedical Sciences, University of South Alabama, Mobile, AL 36688, USA
    J Physiol 552:335-44. 2003
    The reduction of oxygen to water proceeds via one electron at a time. In the mitochondrial respiratory chain, Complex IV (cytochrome oxidase) retains all partially reduced intermediates until full reduction is achieved...
  19. pmc Brain metabolism dictates the polarity of astrocyte control over arterioles
    Grant R J Gordon
    Brain Research Centre, Department of Psychiatry, University of British Columbia, British Columbia T2N 2B5, Canada
    Nature 456:745-9. 2008
    ..When oxygen availability is lowered and astrocyte calcium concentration is elevated, astrocyte glycolysis and lactate release ..
  20. ncbi Pigment epithelium-derived factor: a potent inhibitor of angiogenesis
    D W Dawson
    Department of Microbiology Immunology, Department of Pathology, Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
    Science 285:245-8. 1999
    ..The amount of inhibitory PEDF produced by retinal cells was positively correlated with oxygen concentrations, suggesting that its loss plays a permissive role in ischemia-driven retinal neovascularization...
  21. ncbi Distributed neural representation of expected value
    Brian Knutson
    Department of Psychology, Stanford University, Stanford, California 94305, USA
    J Neurosci 25:4806-12. 2005
  22. ncbi The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    P H Maxwell
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Nature 399:271-5. 1999
    ..ions or iron chelators mimic hypoxia, indicating that the stimuli may interact through effects on a ferroprotein oxygen sensor...
  23. doi An oxygen reduction electrocatalyst based on carbon nanotube-graphene complexes
    Yanguang Li
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    Nat Nanotechnol 7:394-400. 2012
    b>Oxygen reduction reaction catalysts based on precious metals such as platinum or its alloys are routinely used in fuel cells because of their high activity...
  24. pmc Physiological levels of reactive oxygen species are required to maintain genomic stability in stem cells
    Tao Sheng Li
    The Heart Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Stem Cells 28:1178-85. 2010
    ..We investigated the possibility that reactive oxygen species (ROSs) influence genomic stability in cardiac and embryonic stem cells...
  25. doi The enigmatic reaction of flavins with oxygen
    Pimchai Chaiyen
    Department of Biochemistry and Center of Excellence in Protein Structure and Function, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
    Trends Biochem Sci 37:373-80. 2012
    The reaction of flavoenzymes with oxygen remains a fascinating area of research because of its relevance for reactive oxygen species (ROS) generation...
  26. doi Flooding stress: acclimations and genetic diversity
    J Bailey-Serres
    Center for Plant Cell Biology, University of California, Riverside, California 92521, USA
    Annu Rev Plant Biol 59:313-39. 2008
  27. doi An oxygen-regulated switch in the protein synthesis machinery
    James Uniacke
    Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Nature 486:126-9. 2012
    ..Low oxygen tension (hypoxia) represses cap-mediated translation by sequestering eIF4E through mammalian target of rapamycin (..
  28. ncbi Interpreting the BOLD signal
    Nikos K Logothetis
    Max Planck Institut für biologische Kybernetik, Tubingen, Germany
    Annu Rev Physiol 66:735-69. 2004
    ..We describe our current understanding of the causal relationships between neural activity and the blood-oxygen-level-dependent (BOLD) signal, and we review how these analyses have challenged some basic assumptions that have ..
  29. pmc Electrophysiological signatures of resting state networks in the human brain
    D Mantini
    Institute of Advanced Biomedical Technologies and Department of Clinical Sciences and Bio imaging, G d Annunzio University Foundation, G D Annunzio University, Chieti 66013, Italy
    Proc Natl Acad Sci U S A 104:13170-5. 2007
    ..This result supports for the first time in humans the coalescence of several brain rhythms within large-scale brain networks as suggested by biophysical studies...
  30. ncbi Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
    Rebecca J Appelhoff
    Henry Wellcome Bldg of Genomic Medicine, Roosevelt Drive, Headington, Oxford, UK
    J Biol Chem 279:38458-65. 2004
    Hypoxia-inducible factor (HIF) is a transcriptional regulator that plays a key role in many aspects of oxygen homeostasis...
  31. ncbi People thinking about thinking people. The role of the temporo-parietal junction in "theory of mind"
    R Saxe
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, NE20 464, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Neuroimage 19:1835-42. 2003
    ..Thus, the role of the TPJ-M in understanding other people appears to be specific to reasoning about the content of mental states...
  32. ncbi Pathways of oxidative damage
    James A Imlay
    Department of Microbiology, University of Illinois, Urbana, Illinois 61801, USA
    Annu Rev Microbiol 57:395-418. 2003
    The phenomenon of oxygen toxicity is universal, but only recently have we begun to understand its basis in molecular terms...
  33. pmc Low O2 tensions and the prevention of differentiation of hES cells
    Toshihiko Ezashi
    Department of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
    Proc Natl Acad Sci U S A 102:4783-8. 2005
    ..In addition, hES cell growth under hypoxia provided enhanced formation of embryoid bodies. Hypoxic culture would appear to be necessary to maintain full pluripotency of hES cells...
  34. ncbi HIF-1: mediator of physiological and pathophysiological responses to hypoxia
    G L Semenza
    Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
    J Appl Physiol (1985) 88:1474-80. 2000
    ..Genetic or pharmacological modulation of HIF-1 activity in vivo may represent a novel therapeutic approach to these disorders...
  35. ncbi Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study
    Amit Anand
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Biol Psychiatry 57:1079-88. 2005
    ..In this study, using functional Magnetic Resonance Imaging (fMRI), we investigated differences in cortico-limbic activity and connectivity between depressed patients and healthy controls...
  36. ncbi An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension
    Sebastien Bonnet
    Vascular Biology Group, Division of Cardiology, University of Alberta, Edmonton, Canada
    Circulation 113:2630-41. 2006
    ..The cause of pulmonary arterial hypertension (PAH) was investigated in humans and fawn hooded rats (FHR), a spontaneously pulmonary hypertensive strain...
  37. doi Pd-Pt bimetallic nanodendrites with high activity for oxygen reduction
    Byungkwon Lim
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Science 324:1302-5. 2009
    ..on faceted Pd nanocrystals exhibited relatively large surface areas and particularly active facets toward the oxygen reduction reaction (ORR), the rate-determining step in a proton-exchange membrane fuel cell...
  38. doi Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations
    Christopher J Lengner
    Whitehead Institute for Biomedical Sciences, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 141:872-83. 2010
    ..We describe the establishment of XaXa hESCs derived under physiological oxygen concentrations...
  39. ncbi Architecture of the photosynthetic oxygen-evolving center
    Kristina N Ferreira
    Department of Biological Sciences, Imperial College London, London, SW7 2AZ, UK
    Science 303:1831-8. 2004
    Photosynthesis uses light energy to drive the oxidation of water at an oxygen-evolving catalytic site within photosystem II (PSII). We report the structure of PSII of the cyanobacterium Thermosynechococcus elongatus at 3...
  40. doi Microbial metatranscriptomics in a permanent marine oxygen minimum zone
    Frank J Stewart
    School of Biology, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332, USA
    Environ Microbiol 14:23-40. 2012
    Simultaneous characterization of taxonomic composition, metabolic gene content and gene expression in marine oxygen minimum zones (OMZs) has potential to broaden perspectives on the microbial and biogeochemical dynamics in these ..
  41. pmc Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients
    Dieter Worlitzsch
    Institute of General and Environmental Hygiene, University of Tubingen, Tubingen, Germany
    J Clin Invest 109:317-25. 2002
    ..With P. aeruginosa growth in oxygen restricted environments, local hypoxia was exacerbated and frank anaerobiosis, as detected in vivo, resulted...
  42. doi Oxygen in stem cell biology: a critical component of the stem cell niche
    Ahmed Mohyeldin
    Department of Neurosurgery and Oncology, Brain Tumor Stem Cell Laboratory, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Cell Stem Cell 7:150-61. 2010
    ..This capacity depends on the balance of complex signals in their microenvironment. Low oxygen tensions (hypoxia) maintain undifferentiated states of embryonic, hematopoietic, mesenchymal, and neural stem cell ..
  43. doi Microbial ecology of expanding oxygen minimum zones
    Jody J Wright
    Department of Microbiology and Immunology, University of British Columbia, Life Sciences Institute, 2552 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada
    Nat Rev Microbiol 10:381-94. 2012
    Dissolved oxygen concentration is a crucial organizing principle in marine ecosystems...
  44. doi FePt nanoparticles assembled on graphene as enhanced catalyst for oxygen reduction reaction
    Shaojun Guo
    Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA
    J Am Chem Soc 134:2492-5. 2012
    ..These G/FePt NPs were a more active and durable catalyst for oxygen reduction reaction (ORR) in 0...
  45. doi Metagenome of a versatile chemolithoautotroph from expanding oceanic dead zones
    David A Walsh
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    Science 326:578-82. 2009
    b>Oxygen minimum zones, also known as oceanic "dead zones," are widespread oceanographic features currently expanding because of global warming...
  46. doi How green is the grass on the other side? Frontopolar cortex and the evidence in favor of alternative courses of action
    Erie D Boorman
    Centre for Functional MRI of the Brain, University of Oxford, Oxford 0X3 9DU, UK
    Neuron 62:733-43. 2009
    ..Collectively, these findings reveal complementary prefrontal computations essential for promoting short- and long-term behavioral flexibility...
  47. ncbi Production of reactive oxygen species by mitochondria: central role of complex III
    Qun Chen
    Department of Medicine, Division of Cardiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 278:36027-31. 2003
    The mitochondrial respiratory chain is a major source of reactive oxygen species (ROS) under pathological conditions including myocardial ischemia and reperfusion...
  48. pmc The neural correlates of subjective value during intertemporal choice
    Joseph W Kable
    Center for Neural Science, New York University, 4 Washington Place, Room 809, New York, New York 10003, USA
    Nat Neurosci 10:1625-33. 2007
    ..This similarity provides unambiguous evidence that the subjective value of potential rewards is explicitly represented in the human brain...
  49. doi The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer
    William G Kaelin
    Howard Hughes Medical Institute, Chevy Chase, Maryland 20815 6789, USA
    Nat Rev Cancer 8:865-73. 2008
  50. ncbi Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects
    M Hockel
    Department of Obstetrics and Gynecology, University of Leipzig, Germany
    J Natl Cancer Inst 93:266-76. 2001
    Tissue hypoxia results from an inadequate supply of oxygen (O(2)) that compromises biologic functions. Evidence from experimental and clinical studies increasingly points to a fundamental role for hypoxia in solid tumors...
  51. ncbi Neurophysiological investigation of the basis of the fMRI signal
    N K Logothetis
    Max Planck Institute for Biological Cybernetics, Tuebingen, Germany
    Nature 412:150-7. 2001
    ..field potentials (LFPs), single- and multi-unit spiking activity with highly spatio-temporally resolved blood-oxygen-level-dependent (BOLD) fMRI responses from the visual cortex of monkeys...
  52. pmc A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
    Yoon Young Jang
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Blood 110:3056-63. 2007
    A low-oxygenic niche in bone marrow limits reactive oxygen species (ROS) production, thus providing long-term protection for hematopoietic stem cells (HSCs) from ROS stress...
  53. ncbi The hydrogen hypothesis for the first eukaryote
    W Martin
    Institut fur Genetik, Technische Universitat Braunschweig, Germany
    Nature 392:37-41. 1998
    ..The host's dependence upon molecular hydrogen produced by the symbiont is put forward as the selective principle that forged the common ancestor of eukaryotic cells...
  54. pmc PAS domains: internal sensors of oxygen, redox potential, and light
    B L Taylor
    Department of Microbiology and Molecular Genetics, School of Medicine, Loma Linda University, Loma Linda, California 92350, USA
    Microbiol Mol Biol Rev 63:479-506. 1999
    ..They function as input modules in proteins that sense oxygen, redox potential, light, and some other stimuli...
  55. ncbi Hypoxia-inducible factor 1 (HIF-1) pathway
    Gregg L Semenza
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Broadway Research Building, Suite 671, 733 North Broadway, Baltimore, MD 21205, USA
    Sci STKE 2007:cm8. 2007
    ..A growing number of proteins and small molecules have been identified that regulate HIF-1 activity by modulating the physical or functional interaction of PHD2, VHL, FIH-1, RACK1, or HSP90 with HIF-1alpha...
  56. doi Oxygen sensing in plants is mediated by an N-end rule pathway for protein destabilization
    Francesco Licausi
    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, 14476, Potsdam Golm, Germany
    Nature 479:419-22. 2011
    The majority of eukaryotic organisms rely on molecular oxygen for respiratory energy production...
  57. doi Crystal structure of oxygen-evolving photosystem II at a resolution of 1.9 Å
    Yasufumi Umena
    Department of Chemistry, Graduate School of Science, Osaka City University, 3 3 138 Sugimoto, Sumiyoshi, Osaka 558 8585, Japan
    Nature 473:55-60. 2011
    ..We found that five oxygen atoms served as oxo bridges linking the five metal atoms, and that four water molecules were bound to the Mn(4)CaO(..
  58. ncbi HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
    Huafeng Zhang
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cancer Cell 11:407-20. 2007
    ..We demonstrate that transcription of the gene encoding the coactivator PGC-1beta is C-MYC dependent and that loss of PGC-1beta expression is a major factor contributing to reduced respiration in VHL-deficient renal carcinoma cells...
  59. pmc Redox reactions of phenazine antibiotics with ferric (hydr)oxides and molecular oxygen
    Yun Wang
    Department of Biology, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Environ Sci Technol 42:2380-6. 2008
    ..Ferric (hydr)oxide reduction by reduced phenazines can potentially be inhibited by oxygen, where O2 competes with Fe(III) as the final oxidant The reactivity of reduced phenazines with 02 decreases in the ..
  60. pmc Linking crenarchaeal and bacterial nitrification to anammox in the Black Sea
    Phyllis Lam
    Max Planck Institute for Marine Microbiology, Celsiusstrasse 1, 28359 Bremen, Germany
    Proc Natl Acad Sci U S A 104:7104-9. 2007
    ..in nature, was verified by (15)NO(2)(-) and (15)N(15)N production in (15)NH(4)(+) incubations with no measurable oxygen. It provided a direct local source of nitrite for anammox in the suboxic zone...
  61. pmc FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
    P C Mahon
    Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Genes Dev 15:2675-86. 2001
    Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls angiogenesis, erythropoiesis, and glycolysis via transcriptional activation of target genes under hypoxic conditions...
  62. ncbi Vitamin B6 (pyridoxine) and its derivatives are efficient singlet oxygen quenchers and potential fungal antioxidants
    P Bilski
    Laboratory of Pharmacology and Chemistry, NIEHS Environmental Toxicology Program, Research Triangle Park, NC 27709, USA
    Photochem Photobiol 71:129-34. 2000
    ..fungus Cercospora nicotianae to its own abundantly produced strong photosensitizer of singlet molecular oxygen (1O2), cercosporin. We measured the rate constants (kq) for the quenching of 1O2 phosphorescence by 1-4 in D2O...
  63. pmc Microbial oceanography of anoxic oxygen minimum zones
    Osvaldo Ulloa
    Departamento de Oceanografia, Universidad de Concepcion, Concepción 4070386, Chile
    Proc Natl Acad Sci U S A 109:15996-6003. 2012
    Vast expanses of oxygen-deficient and nitrite-rich water define the major oxygen minimum zones (OMZs) of the global ocean...
  64. ncbi Controversy of free radical hypothesis: reactive oxygen species--cause or consequence of tissue injury?
    I Juranek
    Institute of Experimental Pharmacology, Slovak Academy of Sciences, Dubravska cesta 9, Bratislava, Slovakia
    Gen Physiol Biophys 24:263-78. 2005
    For a decade or two, the hypothesis of causality of various disorders by reactive oxygen species (ROS), due to their potentially harmful effect towards cellular constituents, is one of the most frequently cited in biomedical sciences...
  65. ncbi Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
    Simona Parrinello
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Nat Cell Biol 5:741-7. 2003
    ..fibroblasts and mouse embryonic fibroblasts (MEFs) differ under standard culture conditions, which include 20% oxygen. MEFs did not senesce in physiological (3%) oxygen levels, but underwent a spontaneous event that allowed ..
  66. doi Hypoxia: a window into Mycobacterium tuberculosis latency
    Tige R Rustad
    Seattle Biomedical Research Institute, Seattle, WA, USA
    Cell Microbiol 11:1151-9. 2009
    ..However, multiple studies in vitro and in vivo indicate that M. tuberculosis adapts to oxygen limitation by entering into a metabolically altered state, while awaiting the opportunity to reactivate...
  67. ncbi Integration of oxygen signaling at the consensus HRE
    Roland H Wenger
    Institute of Physiology, Center for Integrative Human Physiology, University of Zurich, CH 8057 Zurich, Switzerland
    Sci STKE 2005:re12. 2005
    ..identified as a transcription factor that regulated erythropoietin gene expression in response to a decrease in oxygen availability in kidney tissue...
  68. doi Sulfur-doped graphene as an efficient metal-free cathode catalyst for oxygen reduction
    Zhi Yang
    Nanomaterials and Chemistry Key Laboratory, Wenzhou University, Wenzhou, 325027, China
    ACS Nano 6:205-11. 2012
    ..arrangement of graphene by doping is a practical strategy for producing significantly improved materials for the oxygen-reduction reaction (ORR) in fuel cells (FCs)...
  69. doi HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha
    Zoltan Arany
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 451:1008-12. 2008
    ..receptor-gamma coactivator-1alpha), a potent metabolic sensor and regulator, is induced by a lack of nutrients and oxygen, and PGC-1alpha powerfully regulates VEGF expression and angiogenesis in cultured muscle cells and skeletal muscle ..
  70. ncbi C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
    A C Epstein
    The Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Cell 107:43-54. 2001
    HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis...
  71. pmc Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival
    E Schipani
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Genes Dev 15:2865-76. 2001
    Breakdown or absence of vascular oxygen delivery is a hallmark of many common human diseases, including cancer, myocardial infarction, and stroke...
  72. pmc Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis
    Kip M Connor
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Nat Protoc 4:1565-73. 2009
    The mouse model of oxygen-induced retinopathy (OIR) has been widely used in studies related to retinopathy of prematurity, proliferative diabetic retinopathy and in studies evaluating the efficacy of antiangiogenic compounds...
  73. ncbi Climate change affects marine fishes through the oxygen limitation of thermal tolerance
    Hans O Portner
    Alfred Wegener Institute for Polar and Marine Research, Animal Ecophysiology, Postfach 12 01 61, 27515 Bremerhaven, Germany
    Science 315:95-7. 2007
    ..various climatic regions led to the hypothesis that, as a unifying principle, a mismatch between the demand for oxygen and the capacity of oxygen supply to tissues is the first mechanism to restrict whole-animal tolerance to thermal ..
  74. pmc Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation
    Christos Polytarchou
    Molecular Oncology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Cancer Res 71:4720-31. 2011
    ..By upregulating miR-21 upon oxygen deprivation, Akt2 downregulates PTEN and activates all three Akt isoforms...
  75. ncbi Characterization of the tuberculous granuloma in murine and human lungs: cellular composition and relative tissue oxygen tension
    Ming C Tsai
    Department of Medicinem Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Cell Microbiol 8:218-32. 2006
    ..EF5), together with immunohistochemical studies targeting endothelial cells were used to examine the relative oxygen tension in tuberculous granulomatous tissues in mice...
  76. pmc Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia
    Kalindi Parmar
    Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:5431-6. 2007
    ..that HSCs and the supporting cells of the stem cell niche are predominantly located at the lowest end of an oxygen gradient in the bone marrow with the implication that regionally defined hypoxia plays a fundamental role in ..
  77. ncbi Early goal-directed therapy in the treatment of severe sepsis and septic shock
    E Rivers
    Department of Emergency Medicine, Henry Ford Health Systems, Case Western Reserve University, Detroit, MI 48202, USA
    N Engl J Med 345:1368-77. 2001
    ..This approach involves adjustments of cardiac preload, afterload, and contractility to balance oxygen delivery with oxygen demand...
  78. pmc Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial
    Alan E Jones
    Department of Emergency Medicine, 1000 Blythe Blvd, Carolinas Medical Center, Charlotte, NC 28203, USA
    JAMA 303:739-46. 2010
    ..Goal-directed resuscitation for severe sepsis and septic shock has been reported to reduce mortality when applied in the emergency department...
  79. pmc Revising the nitrogen cycle in the Peruvian oxygen minimum zone
    Phyllis Lam
    Max Planck Institute for Marine Microbiology, D 28359 Bremen, Germany
    Proc Natl Acad Sci U S A 106:4752-7. 2009
    The oxygen minimum zone (OMZ) of the Eastern Tropical South Pacific (ETSP) is 1 of the 3 major regions in the world where oceanic nitrogen is lost in the pelagic realm...
  80. doi A cryptic sulfur cycle in oxygen-minimum-zone waters off the Chilean coast
    Don E Canfield
    Institute of Biology and Nordic Center for Earth Evolution, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
    Science 330:1375-8. 2010
    Nitrogen cycling is normally thought to dominate the biogeochemistry and microbial ecology of oxygen-minimum zones in marine environments...
  81. ncbi Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
    E Maltepe
    Department of Pathology, Howard Hughes Medical Institute, University of Chicago, Illinois 60637, USA
    Nature 386:403-7. 1997
    ..of xenobiotics, whereas ARNT-HIF-1alpha heterodimers probably regulate those involved in the response to oxygen deprivation...
  82. ncbi Beyond threat: amygdala reactivity across multiple expressions of facial affect
    Daniel A Fitzgerald
    Department of Psychiatry, The University of Chicago, 5841 South Maryland Avenue MC3077 L 466C, Chicago, IL 60637 1470, USA
    Neuroimage 30:1441-8. 2006
    ..These results challenge the notion that the amygdala has a specialized role in processing certain emotions and suggest that the amygdala may have a more general-purpose function in processing salient information from faces...
  83. pmc Reward value coding distinct from risk attitude-related uncertainty coding in human reward systems
    Philippe N Tobler
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    J Neurophysiol 97:1621-32. 2007
    ..These data demonstrate the distinct coding in key reward structures of the two basic and crucial decision parameters, expected value, and uncertainty...
  84. ncbi The biology of VEGF and its receptors
    Napoleone Ferrara
    Department of Molecular Oncology, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nat Med 9:669-76. 2003
    ..VEGF inhibition is also being tested as a strategy for the prevention of angiogenesis, vascular leakage and visual loss in age-related macular degeneration...
  85. ncbi Brain work and brain imaging
    Marcus E Raichle
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Neurosci 29:449-76. 2006
    ..Finally, neuroimaging, with its unique metabolic perspective, has alerted us to the ongoing and costly intrinsic activity within brain systems that most likely represents the largest fraction of the brain's functional activity...
  86. pmc A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    G L Semenza
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Mol Cell Biol 12:5447-54. 1992
    ..We have thus defined a functionally tripartite, 50-nt hypoxia-inducible enhancer which binds several nuclear factors, one of which is induced by hypoxia via de novo protein synthesis...
  87. ncbi HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
    M Ivan
    Dana Farber Cancer Institute and Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Science 292:464-8. 2001
    ..factor) is a transcription factor that plays a pivotal role in cellular adaptation to changes in oxygen availability...
  88. pmc Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus
    Michael D Greicius
    Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305 5235, USA
    Biol Psychiatry 62:429-37. 2007
    ..The goal of this study was to examine resting-state, default-mode network functional connectivity in subjects with major depression and in healthy controls...
  89. pmc Chromatin as an oxygen sensor and active player in the hypoxia response
    Andrew Melvin
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, MSI WTB JBC Complex, University of Dundee, Dundee, Scotland, United Kingdom
    Cell Signal 24:35-43. 2012
    Changes in the availability or demand for oxygen induce dramatic changes at the cellular level...
  90. doi Effects of targeting higher vs lower arterial oxygen saturations on death or disability in extremely preterm infants: a randomized clinical trial
    Barbara Schmidt
    Division of Neonatology, Children s Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Philadelphia, PA, USA
    JAMA 309:2111-20. 2013
    The goal of oxygen therapy is to deliver sufficient oxygen to the tissues while minimizing oxygen toxicity and oxidative stress. It remains uncertain what values of arterial oxygen saturations achieve this balance in preterm infants.
  91. pmc Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy
    K G Pringle
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, SA 5005, Australia
    Hum Reprod Update 16:415-31. 2010
    In the first trimester the extravillous cytotrophoblast cells occlude the uterine spiral arterioles creating a low oxygen environment early in pregnancy, which is essential for pregnancy success...
  92. pmc Label-free oxygen-metabolic photoacoustic microscopy in vivo
    Junjie Yao
    Washington University in St Louis, Department of Biomedical Engineering, One Brookings Drive, St Louis, Missouri 63130, USA
    J Biomed Opt 16:076003. 2011
    Almost all diseases, especially cancer and diabetes, manifest abnormal oxygen metabolism...
  93. pmc The neural bases of emotion regulation: reappraisal and suppression of negative emotion
    Philippe R Goldin
    Department of Psychology, Stanford University, Stanford, California 94305, USA
    Biol Psychiatry 63:577-86. 2008
  94. doi The effects of electrical microstimulation on cortical signal propagation
    Nikos K Logothetis
    Max Planck Institute for Biological Cybernetics, Tubingen, Germany
    Nat Neurosci 13:1283-91. 2010
    ..Taken together, our findings suggest that electrical stimulation disrupts cortico-cortical signal propagation by silencing the output of any neocortical area whose afferents are electrically stimulated...
  95. pmc Investigating neural primacy in Major Depressive Disorder: multivariate Granger causality analysis of resting-state fMRI time-series data
    J P Hamilton
    Department of Psychology, Stanford University, Stanford, CA 94305, USA
    Mol Psychiatry 16:763-72. 2011
    ..neural activity in one or more seed regions predicts subsequent activity in target brain regions, to analyze blood-oxygen-level-dependent (BOLD) data collected during eyes-closed rest from depressed and never-depressed persons...
  96. pmc Different dynamics of performance and brain activation in the time course of perceptual learning
    Yuko Yotsumoto
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Neuron 57:827-33. 2008
    ..These findings indicate that there are distinct temporal phases in the time course of perceptual learning, related to differential dynamics of BOLD activity in visual cortex...
  97. ncbi Theoretical simulation of tumour oxygenation and results from acute and chronic hypoxia
    Alexandru Daşu
    Department of Radiation Sciences, Umea University, S 901 85 Umea, Sweden
    Phys Med Biol 48:2829-42. 2003
    ..The model simulates numerically the fundamental physical processes of oxygen diffusion and consumption in a two-dimensional geometry in order to study the influence of the different ..
  98. ncbi Limiting factors for maximum oxygen uptake and determinants of endurance performance
    D R Bassett
    Department of Exercise Science and Sport Management, University of Tennessee, Knoxville 37996, USA
    Med Sci Sports Exerc 32:70-84. 2000
    In the exercising human, maximal oxygen uptake (VO2max) is limited by the ability of the cardiorespiratory system to deliver oxygen to the exercising muscles...
  99. doi The crystal structure of an oxygen-tolerant hydrogenase uncovers a novel iron-sulphur centre
    Johannes Fritsch
    Mikrobiologie, Institut fur Biologie, Humboldt Universitat zu Berlin, Chausseestraße 117, 10115 Berlin, Germany
    Nature 479:249-52. 2011
    ..These discoveries will have an impact on the design of biological and chemical H(2)-converting catalysts that are capable of cycling H(2) in air...
  100. ncbi Climate change and temperature-dependent biogeography: oxygen limitation of thermal tolerance in animals
    H O Portner
    Alfred Wegener Institut fur Polar und Meeresforschung, Okophysiologie, Bremerhaven, Germany
    Naturwissenschaften 88:137-46. 2001
    ..b>Oxygen levels in body fluids may decrease, reflecting excessive oxygen demand at high temperatures or insufficient ..
  101. pmc Development of distinct control networks through segregation and integration
    Damien A Fair
    Departments of Neurology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:13507-12. 2007
    ..Delay/disruption in the developmental processes of segregation and integration may play a role in disorders of control, such as autism, attention deficit hyperactivity disorder, and Tourette's syndrome...

Research Grants80

  1. Singlet Oxygen Signaling
    Krishna Niyogi; Fiscal Year: 2007
    ..to plants and animals, have evolved sensing, signaling, and protective mechanisms to cope with various reactive oxygen species (ROS) that are inevitably generated both intra- and extracellularly...
  2. Optimization of DNA Repair by Abh8
    Lauren Endres; Fiscal Year: 2013
    Reactive oxygen species and electrophiles arising from endogenous and environmental sources can induce single and double strand breaks in DNA...
  3. Angiotensin Adrenergic Interactions in the Kidney
    Roland C Blantz; Fiscal Year: 2013
    ..Since TNa constitutes the major obligation for kidney oxygen utilization (QO2) (>80%) QO2 changes more or less in parallel with TNa...
  4. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2013
    ..between expression of the mitochondrial uncoupling protein 2 (UCP2), which also regulates production of reactive oxygen species (ROS) and cytosolic calcium, and mast cell activation. There are no effective therapies for CFS...
  5. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2013
    ..5) pollution induces adipose dysfunction via reactive oxygen species (ROS)-dependent activation of endoplasmic reticulum (ER) stress and potentiation of insulin resistance...
  6. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..that releases NO, and 2) a pyrrolidine nitroxide that acts as a trifunctional catalyst of reactive oxygen species degradation: a superoxide dismutase mimetic, a catalase mimic that detoxifies hydrogen peroxide, and a ..
  7. Ang II and Aldosterone Effects on Insulin Resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..posit that activation of serine (Ser) kinase signaling pathways, in conjunction with excess generation of reactive oxygen species (ROS), constitute one of the mechanisms whereby angiotensin II (Ang II) and aldosterone contribute to ..
  8. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012
    ..ischemia-reperfusion induced by reversible coronary ligation, and in cultured cardiomyocytes subjected to oxygen and glucose deprivation (OGD)...
    Enrique A Mesri; Fiscal Year: 2013
    ..labs has led to the identification of the Rac1 GTPase, a signaling mediator that triggers production of reactive oxygen species (ROS) by non-phagocytic NADPH-oxidase (NOX), as a potential major player in KS...
  10. Inhibition of human neutrophil function by Francisella tularensis
    Lee Ann H Allen; Fiscal Year: 2012
    ..Toward this end we will utilize chemiluminescence fluorescence and other biochemical assays to quantify reactive oxygen species;confocal microscopy to localize NADPH oxidase components;immunofluorescence microscopy and immuno-electron ..
    Gary Cecchini; Fiscal Year: 2013
    ..Ubiquinol is then oxidized by the bc1 complex (complex III) and electrons transferred to oxygen through complex IV (cytochrome c oxidase) to produce water...
  12. Effect of PPARy Ligands on Alcohol-Induced Alveolar Macrophage Oxidative Stress
    Samantha M Yeligar; Fiscal Year: 2013
    ..In alveolar macrophages (AMs), NADPH oxidase (Nox) 1, Nox2, and Nox4 are critical sources of reactive oxygen species (ROS), and Nox2 is essential for the respiratory burst involved in killing microbes after phagocytosis...
  13. Functional Genomics of the Mitochondrial Proteome
    Dennis R Winge; Fiscal Year: 2011
    ..program by determining the impact of loss of function mutations in all other candidate proteins on growth, oxygen consumption, OXPHOS supercomplex formation, the metabolome, mitochondrial morphology and transition metal content...
  14. Investigating Mechanism of Intracellular Rotational Transport with Optical T
    Jeffrey N Anker; Fiscal Year: 2012
    ..This inflammation and associated overproduction of reactive oxygen species further oxidize RNA/DNA/proteins, leading to fibrosis, mutagenesis and lung cancer...
  15. Targeting Inflammation for the Amelioration of Cisplatin-Hearing Loss
    Vickram Ramkumar; Fiscal Year: 2011
    ..One current treatment strategy uses antioxidants to decrease reactive oxygen species (ROS), which has been implicated in cisplatin ototoxicity...
  16. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
    ..by applicant): Group A Streptococcus (GAS) employs multiple defense strategies to resist killing by reactive oxygen species (ROS) formed either by reduction of atmospheric oxygen or by phagocytes upon activation of the host ..
  17. DNA methylation of extracellular superoxide dismutase in pulmonary hypertension
    EVA NOZIK GRAYCK; Fiscal Year: 2012
    ..key factor that contributes to the pathogenesis of vascular diseases, including PAH, is an increase in reactive oxygen species, such as superoxide (O2-), that exceed antioxidant capabilities...
  18. Mitochondrial Dysfunction and Adipose Insulin Resistance
    David A Bernlohr; Fiscal Year: 2013
    ..cell culture and molecular studies have correlated increased oxidative stress and the accumulation of reactive oxygen species (ROS) such as superoxide anion and hydroxyl radicals to type 2 diabetes...
  19. Nanoparticle Coupled Antioxidants for Respiratory Illness in Veterans
    RODNEY JON SCHLOSSER; Fiscal Year: 2013
    ..Quick degradation of free radicals results in reactive oxygen species (ROS)4-6. Antioxidant enzymes that metabolize ROS, thus serve as potential therapeutic agents...
  20. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
    ..The addition of the redox catalytic function provides R-801 with the capacity to neutralize not only reactive oxygen species generated by CM administration but also the removal of superoxide anion generated by mitoK+-ATP channel ..
  21. Prostate cancer chemoprevention by penta-galloyl-glucose
    Junxuan Lu; Fiscal Year: 2013
    ..and DU145 (mutant p53, androgen independent) PCa cells as well as caspase- mediated apoptosis involving reactive oxygen species (ROS)...
  22. Vascular dysfunction and oxidative stress in primary amyloidosis
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2010
    ..overall hypothesis that primary amyloid light chains acutely impair endothelial function by increasing reactive oxygen species production in both coronary arterioles and adipose arterioles from subjects without amyloid disease...
  23. Role of the Mammalian Siderophore in Cellular Iron Metabolism and Erythropoiesis
    Laxminarayana R Devireddy; Fiscal Year: 2012
    ..Unbound iron catalyzes the formation of harmful reactive oxygen species;therefore, most biological iron is sequestered to keep it in an unreactive form...
  24. Role of Diabetes in Development of Renal Cell Carcinoma
    SAMY LEWIZ HABIB; Fiscal Year: 2013
    ..Diabetes and hyperglycemia are associated with enhanced production of reactive oxygen species and induce DNA damage by several mechanisms...
  25. Monitoring cellular redox signaling and oxidant stress in vivo
    Paul T Schumacker; Fiscal Year: 2010
    Healthy cells use low levels of reactive oxygen species (ROS) as second messengers in signal transduction pathways. High levels of ROS cause oxidative damage to proteins, lipids and DNA...
  26. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
    ..When an artery is occluded, there is an area of tissue that is deprived of oxygen and nutrients, leading to necrosis and infarction...
  27. Prevention of UV-induced carcinogenesis by cyanidin-3-glucoside
    Xianglin Shi; Fiscal Year: 2013
    ..C3G also functions as an antioxidant by inhibiting the generation of reactive oxygen species and inducing antioxidant-regulative transcription factors...
  28. Systemic Inflammation and Central Nervous System Dysfunction
    Laura L Dugan; Fiscal Year: 2013
    ..Nox2 is designed to produce large amounts of reactive oxygen species (ROS), primarily superoxide anion...
  29. Prolonged Inhibition of Pathologic Neovascularization by Catalytic Antioxidants
    JAMES FRANCIS MCGINNIS; Fiscal Year: 2013
    ..progression of these neovascular diseases is thought to occur through the production of toxic molecules, Reactive Oxygen Species (ROS)...
  30. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2012
    ..focused on novel NADPH- oxidases (Noxes) including Nox1, Nox4 and Nox5, which are major sources of reactive oxygen species in and adjacent to the vessel wall...
  31. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2012
    ..Nitration of mitochondrial proteins is a reversible process dependent on oxygen concentration hence the hypoxic environment or ischemia/reperfusion of the preeclamptic placenta may cause protein ..
    Girija G Konduri; Fiscal Year: 2013
    ..Mitochondrial oxygen consumption is an important source of O2[unreadable]- generation in vascular cells...
  33. Human neutrophils, phospholipase A2 and S.aureus: microbial targets and responses
    William M Nauseef; Fiscal Year: 2013
    ..antimicrobial activity and exert ~ all of their antimicrobial effort within phagosomes, where reactive oxygen species (ROS) and granule contents collaborate to kill and degrade microbes...
  34. Global regulatory interactions in bacterial pathogenesis
    BRIAN AKERLEY; Fiscal Year: 2009
    ..Our results indicate that H. influenzae senses and responds to redox conditions, such as oxygen availability, to control critical virulence properties including the structure of its lipooligosaccharide (LOS) ..
  35. Iron in the pathogenesis of Friedreich's ataxia
    ..total iron do not identify the small catalytic amounts of the metal that are required for the generation of toxic oxygen species...
  36. Analysis of gene regulation of Vibrio cholerae during infection
    Jun Zhu; Fiscal Year: 2013
    ..The inside of the human body is a different niche world around it: in the case of the gastrointestinal tract, the oxygen tension is lower, there are high densities of other bacteria, an perhaps most important, there are adaptive and ..
  37. Antiarrhythmic Mechanisms in the Hearts of Hibernating Mammals
    Lai Hua Xie; Fiscal Year: 2013
    ..Reactive oxygen species (ROS) are released acutely in large amounts during ischemia or ischemia/reperfusion injury...
  38. Pathogenesis of the Metabolic Syndrome
    W Timothy Garvey; Fiscal Year: 2013
    ..metabolome is the result of intrinsic mitochondrial defects that both impair FA oxidation and generate reactive oxygen species (ROS)...
  39. Sirtuin/FOXO Signaling in the Regulation of Bone Mass
    Stavroula Kousteni; Fiscal Year: 2012
    ..by mechanisms that involve decreased defense against oxidative stress and/or increased production of Reactive Oxygen Species (ROS)...
  40. Molecular mechanisms of lung disease in ataxia telangiectasia
    JoAnn M Sekiguchi; Fiscal Year: 2013
    ..roles in the control of oxidative stress, and ATM deficiency leads to increased levels of highly reactive oxygen species as well as defects in antioxidant systems...
  41. Metabolic mechanisms of antiestrogen resistance in breast cancer
    ..We have recently demonstrated that a tumor stroma with increased reactive oxygen species (ROS), low oxidative phosphorylation metabolism (OXPHOS) and high glycolysis is found in aggressive breast ..
  42. Purkinje Origin of Ischemic Ventricular Tachycardia and Fibrillation
    James B Martins; Fiscal Year: 2013
    ..Furthermore the effect of statins may result from inhibition of reactive oxygen species (ROS) since a ROS scavenger called TEMPO blocks both VT and TA in a similar manner while decreasing tissue ..
  43. Mechanism-Based Discovery of Protectants Against Iron-Dependant Oxidative Injury
    JUSTIN M SCHWARTZ; Fiscal Year: 2011
    ..Production of reactive oxygen species (ROS) after reintroduction of oxygenated blood to ischemic tissue is a major precipitating event causing ..
  44. Role of Peroxidasin in Glomerular Matrix Homeostasis
    Gautam Bhave; Fiscal Year: 2013
    ..S. A central derangement in diabetic nephropathy is excessive generation of reactive oxygen species (ROS)...
    ..We have recently discovered that 4-hydroxynonenal (HNE), an aldehyde generated by the action of reactive oxygen species (ROS) on membrane lipids, is an endogenous agonist of TRPA1 which causes peptide release, neurogenic ..
  46. Small Molecule targeting of NADPH oxidase in neutrophils
    Marie Dominique Filippi; Fiscal Year: 2010
    ..This is caused by release of free radical and reactive oxygen species (ROS) and inflammatory cytokines (e.g., TNF-1) from the activated neutrophils infiltrating the lungs...
  47. ECG-derived cardiopulmonary coupling biomarkers of sleep, sleep-breathing, and ca
    Robert J Thomas; Fiscal Year: 2010
    ..The respiratory chemoreflexes track oxygen (O2) and carbon dioxide (CO2) levels in the blood...
  48. Lactoferrin Enhances Growth and Reduces Nosocomial Infection in Preterm Infants
    Karel Petrak; Fiscal Year: 2009
    ..the number of days on mechanical ventilation and/or nasal positive airway pressure, number of days on supplemental oxygen, and overall morbidity and mortality (%)...
  49. Arsenic Trioxide and Acute Myeloid Leukemia
    Yongkui Jing; Fiscal Year: 2012
    ..We and others determined that, through generation of reactive oxygen species (ROS), As2O3 induced apoptosis of APL cells...
  50. Surgical amelioration of type 2 diabetes: Hormones, microbiota and mitochondria
    PETER J contact HAVEL; Fiscal Year: 2010
    ..To this end, mitochondrial function (oxygen uptake, ROS production, mitochondrial coupling, and calcium transport) will be evaluated in mitochondria isolated ..
  51. Nitric Oxide in Hemodialysis AV Fistula Maturation
    Richard A Cohen; Fiscal Year: 2010
    ..We will quantify NO release, measure reactive oxygen species, determine the redox status of the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA), and assess ..
  52. Conditional HSF1 Expression for Ischemic Cardioprotection
    Ivor J Benjamin; Fiscal Year: 2012
    ..Aim 2: Characterize the tissue-specific HSP overexpression for changes in cardiac metabolism and myocardial oxygen consumption under basal and ischemic conditions ex vivo...
  53. Electrochemical tools to measure local cerebral blood flow and metabolism
    ROBERT MARK WIGHTMAN; Fiscal Year: 2013
    ..Measurements will be made in the freely moving rats during intracranial self-stimulation while monitoring oxygen and biogenic amine neurotransmitters. 4...
  54. Prevention of Inherited Retinal Diseases by Therapeutic Rare Earth Nanoparticles
    JAMES FRANCIS MCGINNIS; Fiscal Year: 2010
    ..This is "oxidative stress" as a result of a chronic or acute rise in Reactive Oxygen Species (ROS)...
  55. Nitric Oxide Restoration &Heme Detoxification as Adjunctive Therapies for Cerebr
    ..haptoglobin, hemopexin, protoporphyrin IX and mesoporphyrin IX), inducing hemeoxygenase-1 (HO-1: hyperbaric oxygen, curcumin, furan-2-yl-3-pyridin-2-yl-propenone, -deoxy-delta 12,14-prostaglandin J2) or providing anti-oxidant ..
  56. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2010
    ..accumulation of white fat mass, and potentiates vascular dysfunction via monocyte/macrophage dependent reactive oxygen species (ROS) of NAD(P)H oxidase pathway. To achieve this goal, we first explore the impact of PM2...
  57. Role of Glutathione S-Transferase P in Heart Failure
    Sumanth D Prabhu; Fiscal Year: 2013
    ..stress is a hallmark of heart failure (HF), clinical trials with antioxidants targeting first generation reactive oxygen species (ROS) such as O2/ and H2O2 have not yielded compelling benefits...
  58. Targeting Cell Death to Prevent Ventricular Remodeling and Heart Failure
    Abhinav Diwan; Fiscal Year: 2011
    ..In acute infarction, cardiomyocyte necrosis is inevitable due to oxygen/nutrient deprivation, but is followed by a wave of cell-autonomous death, or apoptosis, in the peri-infarct region...
  59. Intrathoracic Pressure Regulator for Resuscitation
    Keith G Lurie; Fiscal Year: 2011
    ..will augment key physiological parameters including mean femoral systolic and diastolic arterial blood pressure, oxygen saturation, and end tidal carbon dioxide values when compared to patients treated with a sham ITPR device and CPR;..
  60. Prevention of age-associated musculoskeletal loss by n-3 fatty acids
    Md Mizanur Rahman; Fiscal Year: 2013
    ..damage levels of muscle to determine muscle quality;analyze mitochondrial functions by measuring reactive oxygen species and ATP production, membrane potential, respiratory rates, and electron transport complex activities to ..
  61. Protection of Brain Injury from Cyanide Poisoning by Carnosic Acid
    Stuart A Lipton; Fiscal Year: 2013
    ..cyanide-induced neuronal damage, including inhibition of Cytochrome C oxidase (CcOX) and generation of reactive oxygen species (ROS) in response to cyanide- induced lipid peroxidation...
  62. Functional characters of non-coding RNAs in alcoholic liver injury
    Fanyin Meng; Fiscal Year: 2013
    ..the direct effects of alcohol and its toxic metabolites on various cell types in the liver, induction of reactive oxygen species (ROS), upregulation of the inflammatory cascade, and other cell-specific effects in the liver...
  63. Transplatin: A Novel Agent to Mitigate Cisplatin Toxicity
    Vickram Ramkumar; Fiscal Year: 2013
    ..We have pursued hypothesis that cisplatin ototoxicity is mediated by its ability to increase reactive oxygen species (ROS) generation in cochlear cells...
    LELAND CLARK; Fiscal Year: 1992
    New high capacity fluorocarbon emulsions will be tested for their ability to increase brain oxygen availability. The emulsions will be administered intravenously to rabbits having implanted oxygen, hydrogen, glucose, and lactate sensors...
    Norman S Wolf; Fiscal Year: 2010
    ..the lens surface and migration to the interior at abnormal sites, with bits of nuclear DNA, free DNA, and reactive oxygen species (ROS) at those sites we find to be characteristic of ARC...
    JAMES KEHRER; Fiscal Year: 1991
    ..of cell death, has been observed upon reoxygenation of cardiac tissue following a sustained period of hypoxia (oxygen paradox)...
  67. Bacterial Response to Singlet Oxygen
    Timothy Donohue; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Molecular oxygen (O2) is critical to life on this planet;it is a product of oxygenic photosynthesis and it is a substrate for bioenergetic pathways like aerobic respiration...
  68. Fully Biodegradable Polymersome-encapsulated Hemoglobin as a Novel Nanoparticle-b
    ..Vindico) is developing a hemoglobin-based cellular oxygen therapeutic (blood substitute), NanoHeme, based on its proprietary nanoparticle-based delivery platform known as ..
  69. Human Pluripotent Stem Cell Differentiation with Defined O2 & Protein Engagement
    ROBERT SAMUEL LANGER; Fiscal Year: 2010
    ..surface properties incorporating defined extracellular matrix (ECM) components that allow for accurate control of oxygen partial pressure of the cell surface (pO2cell) to provide more physiological conditions and allow strategies to ..
  70. Novel Nitrogen Enriched Air for Fire Suppression
    DONALD STOOKEY; Fiscal Year: 2009
    ..A breathable atmosphere, between 10% and 16% oxygen, is maintained so occupants can safely remove themselves or be rescued;even while starving the fire of oxygen, ..
  71. Mechanisms of Angiogenesis in Retinopathy of Prematurity
    Mary Elizabeth Hartnett; Fiscal Year: 2009
    b>Oxygen fluctuations and hyperoxia are risk factors for severe retinopathy of prematurity (ROP)...
    Marcos Intaglietta; Fiscal Year: 2004
    Our hypothesis is that arterioles are the principal suppliers of oxygen to skeletal muscle at rest and connective tissue, and that a substantial fraction of the oxygen delivered to the tissue by the arterioles is used by the arteriolar ..
    Krystyna Frenkel; Fiscal Year: 1992
    b>Oxygen radicals have been implicated as endogenous initiators of degenerative processes leading to cancer, heart disease and aging...
    Walee Chamulitrat; Fiscal Year: 1999
    Inflammatory states in the gastrointestinal tract (GI) have been described to be associated with oxygen and nitrogen radicals...
  75. Retrievable Blood Oxygen Carrier System
    Agnes E Ostafin; Fiscal Year: 2012
    Responding to ever increasing need for blood substitutes, scientists have developed two types of artificial oxygen carriers (AOC), polymeric hemoglobin and perfluorocarbon based AOC...
  76. Microxymetry Techniques for Cardiomocyte Respiration
    Govindasamy Ilangovan; Fiscal Year: 2005
    Measurements of oxygen consumption and generation of reactive oxygen species (ROS) in cardiomyocytes, assume importance in pathophysiology of ischemic heart disease because large quantities of oxygen free radicals are generated during ..
  77. Molecular Adaptation of Hypoxia in Oxygen Sensing Cells
    David Millhorn; Fiscal Year: 2007
    Mammalian cells require a constant supply of oxygen to maintain energy balance. Hypoxia leads to reduced oxidative phosphorylation and depletion of cellular ATP, which can result in cell death...
  78. Planning Grant for PRESOX Trial
    Neil Finer; Fiscal Year: 2009
    ..infants of greater than 1000 grams have demonstrated that infants resuscitated with room air as compared to 100% oxygen had a shorter time to first breath and cry, higher 5 minute Apgar scores and reduced mortality...
  79. Improved Spin Probes for Magnetic Resonance Imaging of Oxygen and Reactive Oxygen
    LAURA DUGAN; Fiscal Year: 2009
    ..for improved spin probes to help with the diagnosis of and fundamental research into diseases mediated by reactive oxygen species (ROS)...
  80. Sensory control of oxygen-dependent taxis behavior
    WAYNE ARLON JOHNSON; Fiscal Year: 2010
    The evolution and survival of higher life forms on Earth has relied upon an oxygen-enriched atmosphere to drive efficient energy metabolism...