- A default mode of brain function
M E Raichle
Mallinckrodt Institute of Radiology and Departments of Neurology and Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 98:676-82. 2001
..Despite this prediction we identify a baseline state of the normal adult human brain in terms of the brain oxygen extraction fraction or OEF...
- Spreading dead zones and consequences for marine ecosystems
Robert J Diaz
Virginia Institute of Marine Science, College of William and Mary, Gloucester Point, VA 23062, USA
Science 321:926-9. 2008
..accumulation of particulate organic matter, which encourages microbial activity and the consumption of dissolved oxygen in bottom waters...
- Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine
Barbara van Loon
Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
DNA Repair (Amst) 9:604-16. 2010
..Various environmental and endogenous agents, such as reactive oxygen species (ROS), can modify the structural properties of DNA bases and thus damage the DNA...
- Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway
William G Kaelin
Howard Hughes Medical Institute, Boston, MA 02115, USA
Mol Cell 30:393-402. 2008
HIF plays a central role in the transcriptional response to changes in oxygen availability. The PHD family of oxygen-dependent prolyl hydroxylases plays a pivotal role in regulating HIF stability...
- Hypoxia signalling in cancer and approaches to enforce tumour regression
Institute of Signalling, Developmental Biology and Cancer Research, CNRS UMR 6543, University of Nice, Centre Antoine Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
Nature 441:437-43. 2006
..b>Oxygen limitation is central in controlling neovascularization, glucose metabolism, survival and tumour spread...
- Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
The Henry Wellcome Building of Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
Science 292:468-72. 2001
..factor (HIF) is a transcriptional complex that plays a central role in the regulation of gene expression by oxygen. In oxygenated and iron replete cells, HIF-alpha subunits are rapidly destroyed by a mechanism that involves ..
- Antioxidants, oxidative damage and oxygen deprivation stress: a review
Department of Biosciences, Division of Plant Physiology, Viikki Biocenter, FIN 00014 Helsinki University, Finland
Ann Bot 91:179-94. 2003
..of environmental factors including UV stress, pathogen invasion (hypersensitive reaction), herbicide action and oxygen shortage...
- Oxygen sensing by HIF hydroxylases
Christopher J Schofield
The Oxford Centre for Molecular Sciences and The Dyson Perrins Laboratory, Department of Chemistry, South Parks Road, Oxford OX1 3QY, UK
Nat Rev Mol Cell Biol 5:343-54. 2004
- Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1
G L Semenza
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
Annu Rev Cell Dev Biol 15:551-78. 1999
..HIF-1 thus appears to function as a master regulator of O2 homeostasis that plays essential roles in cellular and systemic physiology, development, and pathophysiology...
- Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
G L Wang
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
Proc Natl Acad Sci U S A 92:5510-4. 1995
- Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules
Benjamin J Moeller
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
Cancer Cell 5:429-41. 2004
..Following radiotherapy, tumor reoxygenation leads to: (1) nuclear accumulation of HIF-1 in response to reactive oxygen, and (2) enhanced translation of HIF-1-regulated transcripts secondary to stress granule depolymerization...
- Hypoxia--a key regulatory factor in tumour growth
Adrian L Harris
Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
Nat Rev Cancer 2:38-47. 2002
..Many elements of the hypoxia-response pathway are therefore good candidates for therapeutic targeting...
- A practical guide to single-molecule FRET
Department of Physics, University of Illinois at Urbana Champaign, 1110 West Green Street, Urbana, Illinois 61801, USA
Nat Methods 5:507-16. 2008
..We also describe how a smFRET-capable instrument can be built at a reasonable cost with off-the-shelf components and operated reliably using well-established protocols and freely available software...
- Alloys of platinum and early transition metals as oxygen reduction electrocatalysts
Center for Atomic Scale Materials Design, Department of Physics, Technical University of Denmark, Lyngby, Denmark
Nat Chem 1:552-6. 2009
..will require significant reductions in the amount of expensive Pt contained within their cathodes, which drive the oxygen reduction reaction (ORR)...
- Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
Robert D Guzy
Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
Cell Metab 1:401-8. 2005
Multicellular organisms initiate adaptive responses when oxygen (O(2)) availability decreases, but the underlying mechanism of O(2) sensing remains elusive...
- Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis
Heui Dong Park
Department of Pathobiology, University of Washington, Seattle, WA 98195, USA
Mol Microbiol 48:833-43. 2003
..Together, these results demonstrate that Rv3133c/DosR is a transcription factor of the two-component response regulator class, and that it is the primary mediator of a hypoxic signal within M. tuberculosis...
- Why do cancers have high aerobic glycolysis?
Robert A Gatenby
Department of Radiology, University of Arizona, Tucson, Arizona 85721, USA
Nat Rev Cancer 4:891-9. 2004
..Subsequent cell populations with upregulated glycolysis and acid resistance have a powerful growth advantage, which promotes unconstrained proliferation and invasion...
- Mitochondrial formation of reactive oxygen species
Julio F Turrens
Department of Biomedical Sciences, University of South Alabama, Mobile, AL 36688, USA
J Physiol 552:335-44. 2003
The reduction of oxygen to water proceeds via one electron at a time. In the mitochondrial respiratory chain, Complex IV (cytochrome oxidase) retains all partially reduced intermediates until full reduction is achieved...
- Brain metabolism dictates the polarity of astrocyte control over arterioles
Grant R J Gordon
Brain Research Centre, Department of Psychiatry, University of British Columbia, British Columbia T2N 2B5, Canada
Nature 456:745-9. 2008
..When oxygen availability is lowered and astrocyte calcium concentration is elevated, astrocyte glycolysis and lactate release ..
- Pigment epithelium-derived factor: a potent inhibitor of angiogenesis
D W Dawson
Department of Microbiology Immunology, Department of Pathology, Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
Science 285:245-8. 1999
..The amount of inhibitory PEDF produced by retinal cells was positively correlated with oxygen concentrations, suggesting that its loss plays a permissive role in ischemia-driven retinal neovascularization...
- Distributed neural representation of expected value
Department of Psychology, Stanford University, Stanford, California 94305, USA
J Neurosci 25:4806-12. 2005
- The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
P H Maxwell
Wellcome Trust Centre for Human Genetics, Oxford, UK
Nature 399:271-5. 1999
..ions or iron chelators mimic hypoxia, indicating that the stimuli may interact through effects on a ferroprotein oxygen sensor...
- An oxygen reduction electrocatalyst based on carbon nanotube-graphene complexes
Department of Chemistry, Stanford University, Stanford, California 94305, USA
Nat Nanotechnol 7:394-400. 2012
b>Oxygen reduction reaction catalysts based on precious metals such as platinum or its alloys are routinely used in fuel cells because of their high activity...
- Physiological levels of reactive oxygen species are required to maintain genomic stability in stem cells
Tao Sheng Li
The Heart Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
Stem Cells 28:1178-85. 2010
..We investigated the possibility that reactive oxygen species (ROSs) influence genomic stability in cardiac and embryonic stem cells...
- The enigmatic reaction of flavins with oxygen
Department of Biochemistry and Center of Excellence in Protein Structure and Function, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
Trends Biochem Sci 37:373-80. 2012
The reaction of flavoenzymes with oxygen remains a fascinating area of research because of its relevance for reactive oxygen species (ROS) generation...
- Flooding stress: acclimations and genetic diversity
Center for Plant Cell Biology, University of California, Riverside, California 92521, USA
Annu Rev Plant Biol 59:313-39. 2008
- An oxygen-regulated switch in the protein synthesis machinery
Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Nature 486:126-9. 2012
..Low oxygen tension (hypoxia) represses cap-mediated translation by sequestering eIF4E through mammalian target of rapamycin (..
- Interpreting the BOLD signal
Nikos K Logothetis
Max Planck Institut für biologische Kybernetik, Tubingen, Germany
Annu Rev Physiol 66:735-69. 2004
..We describe our current understanding of the causal relationships between neural activity and the blood-oxygen-level-dependent (BOLD) signal, and we review how these analyses have challenged some basic assumptions that have ..
- Electrophysiological signatures of resting state networks in the human brain
Institute of Advanced Biomedical Technologies and Department of Clinical Sciences and Bio imaging, G d Annunzio University Foundation, G D Annunzio University, Chieti 66013, Italy
Proc Natl Acad Sci U S A 104:13170-5. 2007
..This result supports for the first time in humans the coalescence of several brain rhythms within large-scale brain networks as suggested by biophysical studies...
- Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
Rebecca J Appelhoff
Henry Wellcome Bldg of Genomic Medicine, Roosevelt Drive, Headington, Oxford, UK
J Biol Chem 279:38458-65. 2004
Hypoxia-inducible factor (HIF) is a transcriptional regulator that plays a key role in many aspects of oxygen homeostasis...
- People thinking about thinking people. The role of the temporo-parietal junction in "theory of mind"
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, NE20 464, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Neuroimage 19:1835-42. 2003
..Thus, the role of the TPJ-M in understanding other people appears to be specific to reasoning about the content of mental states...
- Pathways of oxidative damage
James A Imlay
Department of Microbiology, University of Illinois, Urbana, Illinois 61801, USA
Annu Rev Microbiol 57:395-418. 2003
The phenomenon of oxygen toxicity is universal, but only recently have we begun to understand its basis in molecular terms...
- Low O2 tensions and the prevention of differentiation of hES cells
Department of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
Proc Natl Acad Sci U S A 102:4783-8. 2005
..In addition, hES cell growth under hypoxia provided enhanced formation of embryoid bodies. Hypoxic culture would appear to be necessary to maintain full pluripotency of hES cells...
- HIF-1: mediator of physiological and pathophysiological responses to hypoxia
G L Semenza
Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
J Appl Physiol (1985) 88:1474-80. 2000
..Genetic or pharmacological modulation of HIF-1 activity in vivo may represent a novel therapeutic approach to these disorders...
- Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Biol Psychiatry 57:1079-88. 2005
..In this study, using functional Magnetic Resonance Imaging (fMRI), we investigated differences in cortico-limbic activity and connectivity between depressed patients and healthy controls...
- An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension
Vascular Biology Group, Division of Cardiology, University of Alberta, Edmonton, Canada
Circulation 113:2630-41. 2006
..The cause of pulmonary arterial hypertension (PAH) was investigated in humans and fawn hooded rats (FHR), a spontaneously pulmonary hypertensive strain...
- Pd-Pt bimetallic nanodendrites with high activity for oxygen reduction
Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
Science 324:1302-5. 2009
..on faceted Pd nanocrystals exhibited relatively large surface areas and particularly active facets toward the oxygen reduction reaction (ORR), the rate-determining step in a proton-exchange membrane fuel cell...
- Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations
Christopher J Lengner
Whitehead Institute for Biomedical Sciences, 9 Cambridge Center, Cambridge, MA 02142, USA
Cell 141:872-83. 2010
..We describe the establishment of XaXa hESCs derived under physiological oxygen concentrations...
- Architecture of the photosynthetic oxygen-evolving center
Kristina N Ferreira
Department of Biological Sciences, Imperial College London, London, SW7 2AZ, UK
Science 303:1831-8. 2004
Photosynthesis uses light energy to drive the oxidation of water at an oxygen-evolving catalytic site within photosystem II (PSII). We report the structure of PSII of the cyanobacterium Thermosynechococcus elongatus at 3...
- Microbial metatranscriptomics in a permanent marine oxygen minimum zone
Frank J Stewart
School of Biology, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332, USA
Environ Microbiol 14:23-40. 2012
Simultaneous characterization of taxonomic composition, metabolic gene content and gene expression in marine oxygen minimum zones (OMZs) has potential to broaden perspectives on the microbial and biogeochemical dynamics in these ..
- Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients
Institute of General and Environmental Hygiene, University of Tubingen, Tubingen, Germany
J Clin Invest 109:317-25. 2002
..With P. aeruginosa growth in oxygen restricted environments, local hypoxia was exacerbated and frank anaerobiosis, as detected in vivo, resulted...
- Oxygen in stem cell biology: a critical component of the stem cell niche
Department of Neurosurgery and Oncology, Brain Tumor Stem Cell Laboratory, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
Cell Stem Cell 7:150-61. 2010
..This capacity depends on the balance of complex signals in their microenvironment. Low oxygen tensions (hypoxia) maintain undifferentiated states of embryonic, hematopoietic, mesenchymal, and neural stem cell ..
- Microbial ecology of expanding oxygen minimum zones
Jody J Wright
Department of Microbiology and Immunology, University of British Columbia, Life Sciences Institute, 2552 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada
Nat Rev Microbiol 10:381-94. 2012
Dissolved oxygen concentration is a crucial organizing principle in marine ecosystems...
- FePt nanoparticles assembled on graphene as enhanced catalyst for oxygen reduction reaction
Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA
J Am Chem Soc 134:2492-5. 2012
..These G/FePt NPs were a more active and durable catalyst for oxygen reduction reaction (ORR) in 0...
- Metagenome of a versatile chemolithoautotroph from expanding oceanic dead zones
David A Walsh
Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
Science 326:578-82. 2009
b>Oxygen minimum zones, also known as oceanic "dead zones," are widespread oceanographic features currently expanding because of global warming...
- How green is the grass on the other side? Frontopolar cortex and the evidence in favor of alternative courses of action
Erie D Boorman
Centre for Functional MRI of the Brain, University of Oxford, Oxford 0X3 9DU, UK
Neuron 62:733-43. 2009
..Collectively, these findings reveal complementary prefrontal computations essential for promoting short- and long-term behavioral flexibility...
- Production of reactive oxygen species by mitochondria: central role of complex III
Department of Medicine, Division of Cardiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Biol Chem 278:36027-31. 2003
The mitochondrial respiratory chain is a major source of reactive oxygen species (ROS) under pathological conditions including myocardial ischemia and reperfusion...
- The neural correlates of subjective value during intertemporal choice
Joseph W Kable
Center for Neural Science, New York University, 4 Washington Place, Room 809, New York, New York 10003, USA
Nat Neurosci 10:1625-33. 2007
..This similarity provides unambiguous evidence that the subjective value of potential rewards is explicitly represented in the human brain...
- The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer
William G Kaelin
Howard Hughes Medical Institute, Chevy Chase, Maryland 20815 6789, USA
Nat Rev Cancer 8:865-73. 2008
- Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects
Department of Obstetrics and Gynecology, University of Leipzig, Germany
J Natl Cancer Inst 93:266-76. 2001
Tissue hypoxia results from an inadequate supply of oxygen (O(2)) that compromises biologic functions. Evidence from experimental and clinical studies increasingly points to a fundamental role for hypoxia in solid tumors...
- Neurophysiological investigation of the basis of the fMRI signal
N K Logothetis
Max Planck Institute for Biological Cybernetics, Tuebingen, Germany
Nature 412:150-7. 2001
..field potentials (LFPs), single- and multi-unit spiking activity with highly spatio-temporally resolved blood-oxygen-level-dependent (BOLD) fMRI responses from the visual cortex of monkeys...
- A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
Yoon Young Jang
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Blood 110:3056-63. 2007
A low-oxygenic niche in bone marrow limits reactive oxygen species (ROS) production, thus providing long-term protection for hematopoietic stem cells (HSCs) from ROS stress...
- The hydrogen hypothesis for the first eukaryote
Institut fur Genetik, Technische Universitat Braunschweig, Germany
Nature 392:37-41. 1998
..The host's dependence upon molecular hydrogen produced by the symbiont is put forward as the selective principle that forged the common ancestor of eukaryotic cells...
- PAS domains: internal sensors of oxygen, redox potential, and light
B L Taylor
Department of Microbiology and Molecular Genetics, School of Medicine, Loma Linda University, Loma Linda, California 92350, USA
Microbiol Mol Biol Rev 63:479-506. 1999
..They function as input modules in proteins that sense oxygen, redox potential, light, and some other stimuli...
- Hypoxia-inducible factor 1 (HIF-1) pathway
Gregg L Semenza
Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Broadway Research Building, Suite 671, 733 North Broadway, Baltimore, MD 21205, USA
Sci STKE 2007:cm8. 2007
..A growing number of proteins and small molecules have been identified that regulate HIF-1 activity by modulating the physical or functional interaction of PHD2, VHL, FIH-1, RACK1, or HSP90 with HIF-1alpha...
- Oxygen sensing in plants is mediated by an N-end rule pathway for protein destabilization
Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, 14476, Potsdam Golm, Germany
Nature 479:419-22. 2011
The majority of eukaryotic organisms rely on molecular oxygen for respiratory energy production...
- Crystal structure of oxygen-evolving photosystem II at a resolution of 1.9 Å
Department of Chemistry, Graduate School of Science, Osaka City University, 3 3 138 Sugimoto, Sumiyoshi, Osaka 558 8585, Japan
Nature 473:55-60. 2011
..We found that five oxygen atoms served as oxo bridges linking the five metal atoms, and that four water molecules were bound to the Mn(4)CaO(..
- HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cancer Cell 11:407-20. 2007
..We demonstrate that transcription of the gene encoding the coactivator PGC-1beta is C-MYC dependent and that loss of PGC-1beta expression is a major factor contributing to reduced respiration in VHL-deficient renal carcinoma cells...
- Redox reactions of phenazine antibiotics with ferric (hydr)oxides and molecular oxygen
Department of Biology, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
Environ Sci Technol 42:2380-6. 2008
..Ferric (hydr)oxide reduction by reduced phenazines can potentially be inhibited by oxygen, where O2 competes with Fe(III) as the final oxidant The reactivity of reduced phenazines with 02 decreases in the ..
- Linking crenarchaeal and bacterial nitrification to anammox in the Black Sea
Max Planck Institute for Marine Microbiology, Celsiusstrasse 1, 28359 Bremen, Germany
Proc Natl Acad Sci U S A 104:7104-9. 2007
..in nature, was verified by (15)NO(2)(-) and (15)N(15)N production in (15)NH(4)(+) incubations with no measurable oxygen. It provided a direct local source of nitrite for anammox in the suboxic zone...
- FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
P C Mahon
Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
Genes Dev 15:2675-86. 2001
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls angiogenesis, erythropoiesis, and glycolysis via transcriptional activation of target genes under hypoxic conditions...
- Vitamin B6 (pyridoxine) and its derivatives are efficient singlet oxygen quenchers and potential fungal antioxidants
Laboratory of Pharmacology and Chemistry, NIEHS Environmental Toxicology Program, Research Triangle Park, NC 27709, USA
Photochem Photobiol 71:129-34. 2000
..fungus Cercospora nicotianae to its own abundantly produced strong photosensitizer of singlet molecular oxygen (1O2), cercosporin. We measured the rate constants (kq) for the quenching of 1O2 phosphorescence by 1-4 in D2O...
- Microbial oceanography of anoxic oxygen minimum zones
Departamento de Oceanografia, Universidad de Concepcion, Concepción 4070386, Chile
Proc Natl Acad Sci U S A 109:15996-6003. 2012
Vast expanses of oxygen-deficient and nitrite-rich water define the major oxygen minimum zones (OMZs) of the global ocean...
- Controversy of free radical hypothesis: reactive oxygen species--cause or consequence of tissue injury?
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Dubravska cesta 9, Bratislava, Slovakia
Gen Physiol Biophys 24:263-78. 2005
For a decade or two, the hypothesis of causality of various disorders by reactive oxygen species (ROS), due to their potentially harmful effect towards cellular constituents, is one of the most frequently cited in biomedical sciences...
- Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
Nat Cell Biol 5:741-7. 2003
..fibroblasts and mouse embryonic fibroblasts (MEFs) differ under standard culture conditions, which include 20% oxygen. MEFs did not senesce in physiological (3%) oxygen levels, but underwent a spontaneous event that allowed ..
- Hypoxia: a window into Mycobacterium tuberculosis latency
Tige R Rustad
Seattle Biomedical Research Institute, Seattle, WA, USA
Cell Microbiol 11:1151-9. 2009
..However, multiple studies in vitro and in vivo indicate that M. tuberculosis adapts to oxygen limitation by entering into a metabolically altered state, while awaiting the opportunity to reactivate...
- Integration of oxygen signaling at the consensus HRE
Roland H Wenger
Institute of Physiology, Center for Integrative Human Physiology, University of Zurich, CH 8057 Zurich, Switzerland
Sci STKE 2005:re12. 2005
..identified as a transcription factor that regulated erythropoietin gene expression in response to a decrease in oxygen availability in kidney tissue...
- Sulfur-doped graphene as an efficient metal-free cathode catalyst for oxygen reduction
Nanomaterials and Chemistry Key Laboratory, Wenzhou University, Wenzhou, 325027, China
ACS Nano 6:205-11. 2012
..arrangement of graphene by doping is a practical strategy for producing significantly improved materials for the oxygen-reduction reaction (ORR) in fuel cells (FCs)...
- HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha
Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 451:1008-12. 2008
..receptor-gamma coactivator-1alpha), a potent metabolic sensor and regulator, is induced by a lack of nutrients and oxygen, and PGC-1alpha powerfully regulates VEGF expression and angiogenesis in cultured muscle cells and skeletal muscle ..
- C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
A C Epstein
The Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
Cell 107:43-54. 2001
HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis...
- Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Genes Dev 15:2865-76. 2001
Breakdown or absence of vascular oxygen delivery is a hallmark of many common human diseases, including cancer, myocardial infarction, and stroke...
- Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis
Kip M Connor
Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
Nat Protoc 4:1565-73. 2009
The mouse model of oxygen-induced retinopathy (OIR) has been widely used in studies related to retinopathy of prematurity, proliferative diabetic retinopathy and in studies evaluating the efficacy of antiangiogenic compounds...
- Climate change affects marine fishes through the oxygen limitation of thermal tolerance
Hans O Portner
Alfred Wegener Institute for Polar and Marine Research, Animal Ecophysiology, Postfach 12 01 61, 27515 Bremerhaven, Germany
Science 315:95-7. 2007
..various climatic regions led to the hypothesis that, as a unifying principle, a mismatch between the demand for oxygen and the capacity of oxygen supply to tissues is the first mechanism to restrict whole-animal tolerance to thermal ..
- Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation
Molecular Oncology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111, USA
Cancer Res 71:4720-31. 2011
..By upregulating miR-21 upon oxygen deprivation, Akt2 downregulates PTEN and activates all three Akt isoforms...
- Characterization of the tuberculous granuloma in murine and human lungs: cellular composition and relative tissue oxygen tension
Ming C Tsai
Department of Medicinem Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
Cell Microbiol 8:218-32. 2006
..EF5), together with immunohistochemical studies targeting endothelial cells were used to examine the relative oxygen tension in tuberculous granulomatous tissues in mice...
- Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia
Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 104:5431-6. 2007
..that HSCs and the supporting cells of the stem cell niche are predominantly located at the lowest end of an oxygen gradient in the bone marrow with the implication that regionally defined hypoxia plays a fundamental role in ..
- Early goal-directed therapy in the treatment of severe sepsis and septic shock
Department of Emergency Medicine, Henry Ford Health Systems, Case Western Reserve University, Detroit, MI 48202, USA
N Engl J Med 345:1368-77. 2001
..This approach involves adjustments of cardiac preload, afterload, and contractility to balance oxygen delivery with oxygen demand...
- Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial
Alan E Jones
Department of Emergency Medicine, 1000 Blythe Blvd, Carolinas Medical Center, Charlotte, NC 28203, USA
JAMA 303:739-46. 2010
..Goal-directed resuscitation for severe sepsis and septic shock has been reported to reduce mortality when applied in the emergency department...
- Revising the nitrogen cycle in the Peruvian oxygen minimum zone
Max Planck Institute for Marine Microbiology, D 28359 Bremen, Germany
Proc Natl Acad Sci U S A 106:4752-7. 2009
The oxygen minimum zone (OMZ) of the Eastern Tropical South Pacific (ETSP) is 1 of the 3 major regions in the world where oceanic nitrogen is lost in the pelagic realm...
- A cryptic sulfur cycle in oxygen-minimum-zone waters off the Chilean coast
Don E Canfield
Institute of Biology and Nordic Center for Earth Evolution, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
Science 330:1375-8. 2010
Nitrogen cycling is normally thought to dominate the biogeochemistry and microbial ecology of oxygen-minimum zones in marine environments...
- Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
Department of Pathology, Howard Hughes Medical Institute, University of Chicago, Illinois 60637, USA
Nature 386:403-7. 1997
..of xenobiotics, whereas ARNT-HIF-1alpha heterodimers probably regulate those involved in the response to oxygen deprivation...
- Beyond threat: amygdala reactivity across multiple expressions of facial affect
Daniel A Fitzgerald
Department of Psychiatry, The University of Chicago, 5841 South Maryland Avenue MC3077 L 466C, Chicago, IL 60637 1470, USA
Neuroimage 30:1441-8. 2006
..These results challenge the notion that the amygdala has a specialized role in processing certain emotions and suggest that the amygdala may have a more general-purpose function in processing salient information from faces...
- Reward value coding distinct from risk attitude-related uncertainty coding in human reward systems
Philippe N Tobler
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
J Neurophysiol 97:1621-32. 2007
..These data demonstrate the distinct coding in key reward structures of the two basic and crucial decision parameters, expected value, and uncertainty...
- The biology of VEGF and its receptors
Department of Molecular Oncology, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
Nat Med 9:669-76. 2003
..VEGF inhibition is also being tested as a strategy for the prevention of angiogenesis, vascular leakage and visual loss in age-related macular degeneration...
- Brain work and brain imaging
Marcus E Raichle
Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Annu Rev Neurosci 29:449-76. 2006
..Finally, neuroimaging, with its unique metabolic perspective, has alerted us to the ongoing and costly intrinsic activity within brain systems that most likely represents the largest fraction of the brain's functional activity...
- A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
G L Semenza
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
Mol Cell Biol 12:5447-54. 1992
..We have thus defined a functionally tripartite, 50-nt hypoxia-inducible enhancer which binds several nuclear factors, one of which is induced by hypoxia via de novo protein synthesis...
- HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
Dana Farber Cancer Institute and Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Science 292:464-8. 2001
..factor) is a transcription factor that plays a pivotal role in cellular adaptation to changes in oxygen availability...
- Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus
Michael D Greicius
Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305 5235, USA
Biol Psychiatry 62:429-37. 2007
..The goal of this study was to examine resting-state, default-mode network functional connectivity in subjects with major depression and in healthy controls...
- Chromatin as an oxygen sensor and active player in the hypoxia response
Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, MSI WTB JBC Complex, University of Dundee, Dundee, Scotland, United Kingdom
Cell Signal 24:35-43. 2012
Changes in the availability or demand for oxygen induce dramatic changes at the cellular level...
- Effects of targeting higher vs lower arterial oxygen saturations on death or disability in extremely preterm infants: a randomized clinical trial
Division of Neonatology, Children s Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Philadelphia, PA, USA
JAMA 309:2111-20. 2013
The goal of oxygen therapy is to deliver sufficient oxygen to the tissues while minimizing oxygen toxicity and oxidative stress. It remains uncertain what values of arterial oxygen saturations achieve this balance in preterm infants.
- Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy
K G Pringle
Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, SA 5005, Australia
Hum Reprod Update 16:415-31. 2010
In the first trimester the extravillous cytotrophoblast cells occlude the uterine spiral arterioles creating a low oxygen environment early in pregnancy, which is essential for pregnancy success...
- Label-free oxygen-metabolic photoacoustic microscopy in vivo
Washington University in St Louis, Department of Biomedical Engineering, One Brookings Drive, St Louis, Missouri 63130, USA
J Biomed Opt 16:076003. 2011
Almost all diseases, especially cancer and diabetes, manifest abnormal oxygen metabolism...
- The neural bases of emotion regulation: reappraisal and suppression of negative emotion
Philippe R Goldin
Department of Psychology, Stanford University, Stanford, California 94305, USA
Biol Psychiatry 63:577-86. 2008
- The effects of electrical microstimulation on cortical signal propagation
Nikos K Logothetis
Max Planck Institute for Biological Cybernetics, Tubingen, Germany
Nat Neurosci 13:1283-91. 2010
..Taken together, our findings suggest that electrical stimulation disrupts cortico-cortical signal propagation by silencing the output of any neocortical area whose afferents are electrically stimulated...
- Investigating neural primacy in Major Depressive Disorder: multivariate Granger causality analysis of resting-state fMRI time-series data
J P Hamilton
Department of Psychology, Stanford University, Stanford, CA 94305, USA
Mol Psychiatry 16:763-72. 2011
..neural activity in one or more seed regions predicts subsequent activity in target brain regions, to analyze blood-oxygen-level-dependent (BOLD) data collected during eyes-closed rest from depressed and never-depressed persons...
- Different dynamics of performance and brain activation in the time course of perceptual learning
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
Neuron 57:827-33. 2008
..These findings indicate that there are distinct temporal phases in the time course of perceptual learning, related to differential dynamics of BOLD activity in visual cortex...
- Theoretical simulation of tumour oxygenation and results from acute and chronic hypoxia
Department of Radiation Sciences, Umea University, S 901 85 Umea, Sweden
Phys Med Biol 48:2829-42. 2003
..The model simulates numerically the fundamental physical processes of oxygen diffusion and consumption in a two-dimensional geometry in order to study the influence of the different ..
- Limiting factors for maximum oxygen uptake and determinants of endurance performance
D R Bassett
Department of Exercise Science and Sport Management, University of Tennessee, Knoxville 37996, USA
Med Sci Sports Exerc 32:70-84. 2000
In the exercising human, maximal oxygen uptake (VO2max) is limited by the ability of the cardiorespiratory system to deliver oxygen to the exercising muscles...
- The crystal structure of an oxygen-tolerant hydrogenase uncovers a novel iron-sulphur centre
Mikrobiologie, Institut fur Biologie, Humboldt Universitat zu Berlin, Chausseestraße 117, 10115 Berlin, Germany
Nature 479:249-52. 2011
..These discoveries will have an impact on the design of biological and chemical H(2)-converting catalysts that are capable of cycling H(2) in air...
- Climate change and temperature-dependent biogeography: oxygen limitation of thermal tolerance in animals
H O Portner
Alfred Wegener Institut fur Polar und Meeresforschung, Okophysiologie, Bremerhaven, Germany
Naturwissenschaften 88:137-46. 2001
..b>Oxygen levels in body fluids may decrease, reflecting excessive oxygen demand at high temperatures or insufficient ..
- Development of distinct control networks through segregation and integration
Damien A Fair
Departments of Neurology, Washington University, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 104:13507-12. 2007
..Delay/disruption in the developmental processes of segregation and integration may play a role in disorders of control, such as autism, attention deficit hyperactivity disorder, and Tourette's syndrome...