nitric oxide

Summary

Summary: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.

Top Publications

  1. ncbi Nitric oxide and peroxynitrite in health and disease
    Pal Pacher
    Section on Oxidative Stress Tissue Injury, Laboratory of Physiologic Studies, National Institutes of Health, National Institute of Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    Physiol Rev 87:315-424. 2007
  2. ncbi Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force
    Mary C Corretti
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland 21205 1595, USA
    J Am Coll Cardiol 39:257-65. 2002
  3. ncbi Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    S Dimmeler
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Nature 399:601-5. 1999
  4. ncbi Nitric oxide and the immune response
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, Friedrich Alexander University of Erlangen Nuremberg, Wasserturmstrasse 3 5, D 91054 Erlangen, Germany
    Nat Immunol 2:907-16. 2001
  5. ncbi Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide
    Guangwen Ren
    Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 661 Hoes Lane, Piscataway, NJ 08854, USA
    Cell Stem Cell 2:141-50. 2008
  6. ncbi Protein S-nitrosylation: purview and parameters
    Douglas T Hess
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Mol Cell Biol 6:150-66. 2005
  7. ncbi Nitric oxide synthases: structure, function and inhibition
    W K Alderton
    In Vitro Pharmacology Department, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, UK
    Biochem J 357:593-615. 2001
  8. ncbi Adiponectin stimulates production of nitric oxide in vascular endothelial cells
    Hui Chen
    Diabetes Unit, Laboratory of Clinical Investigation, NCCAM, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:45021-6. 2003
  9. ncbi Concepts of neural nitric oxide-mediated transmission
    John Garthwaite
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WCIE 6BT, UK
    Eur J Neurosci 27:2783-802. 2008
  10. ncbi Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani
    H W Murray
    Department of Medicine, Division of Hematology Oncology, Cornell University Medical College, New York 10021, USA
    J Exp Med 189:741-6. 1999

Research Grants

  1. Arginase and Regulation of Nitric Oxide Synthase in ALS
    Rajiv Ratan; Fiscal Year: 2004
  2. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    Christopher S Wilcox; Fiscal Year: 2010
  3. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    Frances Walker; Fiscal Year: 2009
  4. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    Frances Walker; Fiscal Year: 2009
  5. Genetic Basis for Impaired Angiogenic Signaling in BPD
    STEVEN HERBERT ABMAN; Fiscal Year: 2010
  6. MANIPULATION OF PHAGOCYTOSIS IN MACROPHAGES
    Joel Swanson; Fiscal Year: 2003
  7. HOMOCYST(E)INE, OXIDATIVE STRESS, AND NITRIC OXIDE
    Joseph Loscalzo; Fiscal Year: 2000
  8. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    Frances Walker; Fiscal Year: 2006
  9. Nitric Oxide in Pulmonary Hypertension
    Serpil Erzurum; Fiscal Year: 2009
  10. Nitric Oxide Releasing Topical Gel for Burn Wound Healing
    ANJAL SHARMA; Fiscal Year: 2007

Detail Information

Publications287 found, 100 shown here

  1. ncbi Nitric oxide and peroxynitrite in health and disease
    Pal Pacher
    Section on Oxidative Stress Tissue Injury, Laboratory of Physiologic Studies, National Institutes of Health, National Institute of Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    Physiol Rev 87:315-424. 2007
    The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide (NO) has stimulated an extraordinary impetus for scientific research in all the fields of biology and medicine...
  2. ncbi Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force
    Mary C Corretti
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland 21205 1595, USA
    J Am Coll Cardiol 39:257-65. 2002
    ..The technique provokes the release of nitric oxide, resulting in vasodilation that can be quantitated as an index of vasomotor function...
  3. ncbi Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    S Dimmeler
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Nature 399:601-5. 1999
    b>Nitric oxide (NO) produced by the endothelial NO synthase (eNOS) is a fundamental determinant of cardiovascular homesotasis: it regulates systemic blood pressure, vascular remodelling and angiogenesis...
  4. ncbi Nitric oxide and the immune response
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, Friedrich Alexander University of Erlangen Nuremberg, Wasserturmstrasse 3 5, D 91054 Erlangen, Germany
    Nat Immunol 2:907-16. 2001
    During the past two decades, nitric oxide (NO) has been recognized as one of the most versatile players in the immune system...
  5. ncbi Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide
    Guangwen Ren
    Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 661 Hoes Lane, Piscataway, NJ 08854, USA
    Cell Stem Cell 2:141-50. 2008
    ..These cytokine combinations provoke the expression of high levels of several chemokines and inducible nitric oxide synthase (iNOS) by MSCs...
  6. ncbi Protein S-nitrosylation: purview and parameters
    Douglas T Hess
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Mol Cell Biol 6:150-66. 2005
    ..S-nitrosylation thereby conveys a large part of the ubiquitous influence of nitric oxide (NO) on cellular signal transduction, and provides a mechanism for redox-based physiological regulation.
  7. ncbi Nitric oxide synthases: structure, function and inhibition
    W K Alderton
    In Vitro Pharmacology Department, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, UK
    Biochem J 357:593-615. 2001
    This review concentrates on advances in nitric oxide synthase (NOS) structure, function and inhibition made in the last seven years, during which time substantial advances have been made in our understanding of this enzyme family...
  8. ncbi Adiponectin stimulates production of nitric oxide in vascular endothelial cells
    Hui Chen
    Diabetes Unit, Laboratory of Clinical Investigation, NCCAM, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:45021-6. 2003
    ..The vascular action of insulin to stimulate endothelial production of nitric oxide (NO), leading to vasodilation and increased blood flow is an important component of insulin-stimulated whole ..
  9. ncbi Concepts of neural nitric oxide-mediated transmission
    John Garthwaite
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WCIE 6BT, UK
    Eur J Neurosci 27:2783-802. 2008
    As a chemical transmitter in the mammalian central nervous system, nitric oxide (NO) is still thought a bit of an oddity, yet this role extends back to the beginnings of the evolution of the nervous system, predating many of the more ..
  10. ncbi Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani
    H W Murray
    Department of Medicine, Division of Hematology Oncology, Cornell University Medical College, New York 10021, USA
    J Exp Med 189:741-6. 1999
    ..respiratory burst-deficient gp91(phox)-/- (X-linked chronic granulomatous disease [X-CGD]) mice and inducible nitric oxide synthase (iNOS) knockout (KO) mice displayed comparably increased susceptibility...
  11. ncbi Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
    D Fulton
    Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Nature 399:597-601. 1999
    Endothelial nitric oxide synthase (eNOS) is the nitric oxide synthase isoform responsible for maintaining systemic blood pressure, vascular remodelling and angiogenesis...
  12. ncbi Biochemical and functional characterization of three activated macrophage populations
    Justin P Edwards
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Leukoc Biol 80:1298-307. 2006
    ..These are sphingosine kinase-1 and LIGHT (TNF superfamily 14). Thus, Ca-Mphi, Mphi-II, and AA-Mphi represent three populations of cells with different biological functions...
  13. ncbi Endothelial nitric oxide synthase in vascular disease: from marvel to menace
    Ulrich Förstermann
    Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany
    Circulation 113:1708-14. 2006
    b>Nitric oxide (NO*) is an important protective molecule in the vasculature, and endothelial NO* synthase (eNOS) is responsible for most of the vascular NO* produced...
  14. ncbi Reactive oxygen species, antioxidant systems and nitric oxide in peroxisomes
    Luis A del Rio
    Departamento de Bioquimica, Biologia Celular y Molecular de Plantas, Estacion Experimental del Zaidin, CSIC, Apartado 419, E 18080 Granada, Spain
    J Exp Bot 53:1255-72. 2002
    ..for peroxisomes related to reactive oxygen species (ROS), but the recent demonstration of the presence of nitric oxide synthase (NOS) in plant peroxisomes implies that these organelles could also have a function in plant cells as ..
  15. ncbi S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration
    Takashi Uehara
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 441:513-7. 2006
    ..manifesting sporadic Parkinson's or Alzheimer's disease, that PDI is S-nitrosylated, a reaction transferring a nitric oxide (NO) group to a critical cysteine thiol to affect protein function...
  16. ncbi Role of endothelial dysfunction in atherosclerosis
    Jean Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Ave W, Montreal, QC H2W 1R7, Canada
    Circulation 109:III27-32. 2004
    ..Many of these effects are largely mediated by nitric oxide, the most potent endogenous vasodilator...
  17. ncbi Mechanisms underlying endothelial dysfunction in diabetes mellitus
    U Hink
    Universitatskrankenhaus Eppendorf, Germany
    Circ Res 88:E14-22. 2001
    ..endothelial cells in vitro with high concentrations of glucose activates protein kinase C (PKC) and increases nitric oxide synthase (NOS III) gene expression as well as superoxide production. The underlying mechanisms remain unknown...
  18. ncbi The chemical biology of nitric oxide: implications in cellular signaling
    Douglas D Thomas
    Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Free Radic Biol Med 45:18-31. 2008
    b>Nitric oxide (NO) has earned the reputation of being a signaling mediator with many diverse and often opposing biological activities...
  19. ncbi Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
    D K Dalton
    Genentech Inc, South San Francisco, CA 94080
    Science 259:1739-42. 1993
    ..Resting splenic natural killer cell activity was reduced in IFN-gamma-deficient mice. Thus, IFN-gamma is essential for the function of several cell types of the murine immune system...
  20. ncbi Nitric oxide and oxidative stress in vascular disease
    Ulrich Förstermann
    Department of Pharmacology, Johannes Gutenberg University Medical Center, Obere Zahlbacher Strasse 67, 55101, Mainz, Germany
    Pflugers Arch 459:923-39. 2010
    Endothelium-derived nitric oxide (NO) is a paracrine factor that controls vascular tone, inhibits platelet function, prevents adhesion of leukocytes, and reduces proliferation of the intima...
  21. ncbi Protein S-nitrosylation in health and disease: a current perspective
    Matthew W Foster
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Trends Mol Med 15:391-404. 2009
    Protein S-nitrosylation constitutes a large part of the ubiquitous influence of nitric oxide on cellular signal transduction and accumulating evidence indicates important roles for S-nitrosylation both in normal physiology and in a broad ..
  22. ncbi Nitric oxide deficiency in chronic kidney disease
    Chris Baylis
    Division of Nephrology, Hypertension, and Transplantation, Department of Physiology, University of Florida College of Medicine, Gainesville, FL 32667, USA
    Am J Physiol Renal Physiol 294:F1-9. 2008
    The overall production of nitric oxide (NO) is decreased in chronic kidney disease (CKD) which contributes to cardiovascular events and further progression of kidney damage...
  23. ncbi Nitric oxide signaling in brain function, dysfunction, and dementia
    Joern R Steinert
    Neurotoxicity at the Synaptic Interface, MRC Toxicology Unit, University of Leicester, Leicester, UK
    Neuroscientist 16:435-52. 2010
    b>Nitric oxide (NO) is an important signaling molecule that is widely used in the nervous system...
  24. ncbi The hamster as a model of human visceral leishmaniasis: progressive disease and impaired generation of nitric oxide in the face of a prominent Th1-like cytokine response
    P C Melby
    Medical Service, Department of Veterans Affairs Medical Center, South Texas Veterans Health Care System, San Antonio, TX 78284, USA
    J Immunol 166:1912-20. 2001
    ..Thus, although a Th1-like cytokine response was prominent, the major antileishmanial effector mechanism that is responsible for control of infection in mice was absent throughout the course of progressive VL in the hamster...
  25. ncbi Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
    Enzo Nisoli
    Integrated Laboratories Network, Department of Preclinical Sciences, Luigi Sacco Hospital, Milan University, 20157 Milan, Italy
    Science 310:314-7. 2005
    ..Here, we report that calorie restriction for either 3 or 12 months induced endothelial nitric oxide synthase (eNOS) expression and 3',5'-cyclic guanosine monophosphate formation in various tissues of male mice...
  26. ncbi NMDA receptors in hippocampal GABAergic synapses and their role in nitric oxide signaling
    Eszter Szabadits
    Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, H 1083, Budapest, Hungary
    J Neurosci 31:5893-904. 2011
    ..Here, we provide evidence that the retrograde nitric oxide (NO)-cGMP cascade triggered by NMDA receptor (NMDAR) activation plays a role in the control of hippocampal ..
  27. ncbi Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells
    Duk Hee Kang
    Division of Nephrology, Ewha Women s University Hospital, Seoul, Korea
    J Am Soc Nephrol 16:3553-62. 2005
    ..UA also increased HVSMC migration and inhibited HUVEC migration. In HUVEC, UA reduced nitric oxide (NO) release...
  28. ncbi Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase
    Barbara Wegiel
    Transplant Institute, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 108:18849-54. 2011
    ..BV) quells the cellular response to endotoxin-induced inflammation through phosphorylation of endothelial nitric oxide synthase (eNOS)...
  29. ncbi Toward a biochemical understanding of human intervertebral disc degeneration and herniation. Contributions of nitric oxide, interleukins, prostaglandin E2, and matrix metalloproteinases
    J D Kang
    Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pennsylvania, USA
    Spine (Phila Pa 1976) 22:1065-73. 1997
    ..intervertebral disc specimens were cultured to study the effects of interleukin-1 beta on the production of nitric oxide, interleukin-6, prostaglandin E2, and matrix metalloproteinases...
  30. ncbi Direct impairment of vascular function by diesel exhaust particulate through reduced bioavailability of endothelium-derived nitric oxide induced by superoxide free radicals
    Mark R Miller
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    Environ Health Perspect 117:611-6. 2009
    ..Diesel exhaust particulate (DEP) is a key arbiter of the adverse cardiovascular effects of air pollution...
  31. ncbi Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1beta, TNF-alpha and IL-6 in an in-vitro model of brain inflammation
    Henrik Wilms
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Neuroinflammation 7:30. 2010
    ..The purpose of this study was to use an established in vitro model of brain inflammation to determine if DMF modulates the release of neurotoxic molecules from microglia and astrocytes, thus inhibiting glial inflammation...
  32. ncbi Hypoxia-induced iNOS expression in microglia is regulated by the PI3-kinase/Akt/mTOR signaling pathway and activation of hypoxia inducible factor-1alpha
    Dah Yuu Lu
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Biochem Pharmacol 72:992-1000. 2006
    ..In this study, we demonstrated that hypoxia induced iNOS expression by regulation of HIF-1alpha in microglia...
  33. ncbi Antidepressants inhibit interferon-gamma-induced microglial production of IL-6 and nitric oxide
    Sadayuki Hashioka
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, 812 8582 Japan
    Exp Neurol 206:33-42. 2007
    ..IFN-gamma)-induced microglial production of the pro-inflammatory mediators interleukin-6 (IL-6) and nitric oxide (NO)...
  34. ncbi The role of nitric oxide in tumour progression
    Dai Fukumura
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Rev Cancer 6:521-34. 2006
    b>Nitric oxide (NO) and nitric oxide synthases are ubiquitous in malignant tumours and are known to exert both pro- and anti-tumour effects...
  35. ncbi Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Erlangen, D 91054, Germany
    Curr Opin Immunol 12:64-76. 2000
    b>Nitric oxide, nitric oxide derivatives and reactive oxygen intermediates are toxic molecules of the immune system which contribute to the control of microbial pathogens and tumors...
  36. ncbi Nitric oxide, oxidants, and protein tyrosine nitration
    Rafael Radi
    Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, Avda General Flores 2125, 11800 Montevideo, Uruguay
    Proc Natl Acad Sci U S A 101:4003-8. 2004
    ....
  37. ncbi Nitric oxide as a secretory product of mammalian cells
    C Nathan
    Beatrice and Samuel A Seaver Laboratory, Cornell University Medical College, New York, New York 10021
    FASEB J 6:3051-64. 1992
    Evolution has resorted to nitric oxide (NO), a tiny, reactive radical gas, to mediate both servoregulatory and cytotoxic functions...
  38. ncbi S-nitrosylation in cardiovascular signaling
    Brian Lima
    Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Circ Res 106:633-46. 2010
    ..2 decades have passed since the endothelium-derived relaxation factor was reported to be the gaseous molecule nitric oxide (NO)...
  39. ncbi Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: important role of nitric oxide
    J Hoffmann
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Circ Res 89:709-15. 2001
    ..Thus, aging of endothelial cells is associated with decreased NO synthesis and concomitantly increased sensitivity of apoptosis, which may contribute to functional impairment of the endothelial monolayer...
  40. ncbi Exhaled nitric oxide measurements: clinical application and interpretation
    D R Taylor
    Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, P O Box 913, Dunedin, New Zealand
    Thorax 61:817-27. 2006
    The use of exhaled nitric oxide measurements (F(E)NO) in clinical practice is now coming of age. There are a number of theoretical and practical factors which have brought this about...
  41. ncbi Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and -scavenging systems
    Martin Feelisch
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 283:33927-34. 2008
    Although nitrite (NO(2)(-)) and nitrate (NO(3)(-)) have been considered traditionally inert byproducts of nitric oxide (NO) metabolism, recent studies indicate that NO(2)(-) represents an important source of NO for processes ranging from ..
  42. ncbi Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation
    Feng Gao
    Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Circulation 105:1497-502. 2002
    BACKGROUND: Recent evidence from cultured endothelial cell studies suggests that phosphorylation of endothelial nitric oxide synthase (eNOS) through the PI3-kinase-Akt pathway increases NO production...
  43. ncbi Macrophage killing of Leishmania amazonensis amastigotes requires both nitric oxide and superoxide
    Rami M Mukbel
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA
    Am J Trop Med Hyg 76:669-75. 2007
    ..Herein we report that the presence of both superoxide and nitric oxide is necessary for efficient killing of L...
  44. ncbi Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity
    A Bal-Price
    Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, United Kingdom
    J Neurosci 21:6480-91. 2001
    ..glia caused 75-100% necrotic cell death within 48 hr, which was completely prevented by inhibitors of inducible nitric oxide synthase (iNOS) (aminoguanidine or 1400W)...
  45. ncbi Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia
    Ki Kyung Jung
    Pharmacology Department, National Institute of Toxicological Research, KFDA, Seoul 122-704, Republic of Korea
    Life Sci 79:2022-31. 2006
    ..7 microM. It also suppressed both mRNA and protein levels of inducible nitric oxide synthase (iNOS), indicating that this drug may affect iNOS gene expression process...
  46. ncbi Regulation of HIF-1alpha stability through S-nitrosylation
    Fang Li
    Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Mol Cell 26:63-74. 2007
    ..This interaction between NO and HIF-1 sheds new light on their involvement in tumor response to treatment as well as mammalian inflammation process in general...
  47. ncbi Nitric oxide and bone
    R J van't Hof
    Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, UK
    Immunology 103:255-61. 2001
    b>Nitric oxide (NO) is a free radical which has important effects on bone cell function...
  48. ncbi Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells
    Nikki Charles
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cell Stem Cell 6:141-52. 2010
    ..We investigated the potential role of nitric oxide (NO) activity in the perivascular niche (PVN) using a genetic engineered mouse model of PDGF-induced gliomas...
  49. ncbi Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice
    Masanori Ozaki
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 110:331-40. 2002
    b>Nitric oxide (NO) derived from endothelial NO synthase (eNOS) is regarded as a protective factor against atherosclerosis...
  50. ncbi Race-specific differences in endothelial function: predisposition of African Americans to vascular diseases
    Leszek Kalinowski
    Department of Biochemistry, Ohio University, Athens, OH 45701, USA
    Circulation 109:2511-7. 2004
    ..Evidence has accumulated that superoxide (O2-) production and its interaction with nitric oxide (NO), yielding the strong oxidant peroxynitrite (ONOO-), play central roles in vascular pathophysiology...
  51. ncbi Nitric oxide and superoxide in inflammation and immune regulation
    T J Guzik
    Chair of Pharmacology, Jagiellonian University School of Medicine, Poland
    J Physiol Pharmacol 54:469-87. 2003
    b>Nitric oxide (NO) and reactive oxygen species exert multiple modulating effects on inflammation and play a key role in the regulation of immune responses. They affect virtually every step of the development of inflammation...
  52. ncbi Nitric oxide in health and disease of the respiratory system
    Fabio L M Ricciardolo
    Dept of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Physiol Rev 84:731-65. 2004
    During the past decade a plethora of studies have unravelled the multiple roles of nitric oxide (NO) in airway physiology and pathophysiology...
  53. ncbi Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor
    Kenji Matsushita
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 115:139-50. 2003
    b>Nitric oxide (NO) inhibits vascular inflammation, but the molecular basis for its anti-inflammatory properties is unknown...
  54. ncbi IL-10 mediates susceptibility to Leishmania donovani infection
    M L Murphy
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Eur J Immunol 31:2848-56. 2001
    ..Enhanced resistance was accompanied by increased production of IFN-gamma and nitric oxide in BALB/c IL-10-/- mice...
  55. ncbi Mycobacterium tuberculosis WhiB3 responds to O2 and nitric oxide via its [4Fe-4S] cluster and is essential for nutrient starvation survival
    Amit Singh
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 104:11562-7. 2007
    ..tuberculosis (Mtb) is to understand the mechanisms involved in sensing redox signals such as oxygen (O2), nitric oxide (NO), and nutrient depletion, which are thought to play a crucial role in persistence...
  56. ncbi Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways
    Walkyria Oliveira Sampaio
    Department of Physiology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Hypertension 49:185-92. 2007
    ..These novel data highlight the importance of the Ang-(1-7)/Mas axis as a putative regulator of endothelial function...
  57. ncbi Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria
    Tsin W Yeo
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin NT 0810, Australia
    J Exp Med 204:2693-704. 2007
    ..Clinical trials in SM of adjunctive agents to improve endothelial NO bioavailability, including l-arginine, are warranted...
  58. ncbi Interferon gamma activated macrophages kill mycobacteria by nitric oxide induced apoptosis
    Susanne Herbst
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    PLoS ONE 6:e19105. 2011
    ..the phagosome maturation block, nutrient deprivation and exposure to microbicidal effectors including nitric oxide (NO)...
  59. ncbi Nitric oxide, stomatal closure, and abiotic stress
    Steven Neill
    Centre for Research in Plant Science, Faculty of Health and Life Sciences, University of the West of England, Bristol BS16 1QY, UK
    J Exp Bot 59:165-76. 2008
    Various data indicate that nitric oxide (NO) is an endogenous signal in plants that mediates responses to several stimuli...
  60. ncbi Nitrate-nitrite-nitric oxide pathway: implications for anesthesiology and intensive care
    Eddie Weitzberg
    Section of Anesthesiology and Intensive Care, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Anesthesiology 113:1460-75. 2010
    The gaseous radical nitric oxide is involved in numerous physiologic and pathophysiological events important in anesthesiology and intensive care...
  61. ncbi Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis
    Uta Keil
    Department of Pharmacology, Biocenter, University of Frankfurt, 60439 Frankfurt, Germany
    J Biol Chem 279:50310-20. 2004
    ..acute and chronic exposure to increasing concentrations of amyloid beta (Abeta) on mitochondrial function and nitric oxide (NO) production in vitro and in vivo...
  62. ncbi Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria
    Guy C Brown
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK
    Mol Neurobiol 27:325-55. 2003
    ..quot;activated" by inflammatory mediators, and express new proteins such as the inducible isoform of nitric oxide synthase (iNOS)...
  63. ncbi On the specificity of 4-amino-5-methylamino-2',7'-difluorofluorescein as a probe for nitric oxide
    Aneta Balcerczyk
    Department of Molecular Biophysics, University of Lodz, Banacha 12 16, 90 237 Lodz, Poland
    Free Radic Biol Med 39:327-35. 2005
    The specificity of 4-amino-5-methylamino-2',7'-difluorofluorescein (DAF-FM) for nitric oxide was evaluated in in vitro systems. The probe was found fairly specific for nitric oxide...
  64. ncbi Was nitric oxide the first deep electron sink?
    Anne Lise Ducluzeau
    Laboratoire de Bioenergetique et Ingenierie des Proteines, Centre National de la Recherche Scientifique UPR9036, IFR77, Marseille Cedex 20, France
    Trends Biochem Sci 34:9-15. 2009
    ..Based on recent phylogenetic, enzymatic and geochemical results, we propose that, in the earliest Archaean, nitric oxide (NO) and its derivatives nitrate and nitrite served as strongly oxidizing substrates driving the evolution of a ..
  65. ncbi Neisseria gonorrhoeae survival during primary human cervical epithelial cell infection requires nitric oxide and is augmented by progesterone
    Jennifer L Edwards
    The Center for Microbial Pathogenesis, The Research Institute at Nationwide Children s Hospital and the Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
    Infect Immun 78:1202-13. 2010
    ..This, in turn, resulted in a parallel increase in nitric oxide synthase expression...
  66. ncbi Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture)
    Michel Feletou
    Department of Angiology, Institut de Recherches Servier, Suresnes, France
    Am J Physiol Heart Circ Physiol 291:H985-1002. 2006
    ..A reduced bioavailability of nitric oxide (NO), an alteration in the production of prostanoids, including prostacyclin, thromboxane A2, and/or ..
  67. ncbi GAPDH mediates nitrosylation of nuclear proteins
    Michael D Kornberg
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nat Cell Biol 12:1094-100. 2010
    S-nitrosylation of proteins by nitric oxide is a major mode of signalling in cells. S-nitrosylation can mediate the regulation of a range of proteins, including prominent nuclear proteins, such as HDAC2 (ref. 2) and PARP1 (ref. 3)...
  68. ncbi Hydrogen peroxide-mediated activation of MAP kinase 6 modulates nitric oxide biosynthesis and signal transduction in Arabidopsis
    Pengcheng Wang
    Laboratory of Plant Stress Biology, Department of Biology, Henan University, Kaifeng 475001, China
    Plant Cell 22:2981-98. 2010
    b>Nitric oxide (NO) is a bioactive molecule that functions in numerous physiological and developmental processes in plants, including lateral root development...
  69. ncbi c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair
    Keigo Machida
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Hepatology 52:480-92. 2010
    ..Here, we studied the role of c-Jun, signal transducer and activator of transcription 3 (STAT3), and nitric oxide (NO) in spontaneous and diethylnitrosamine (DEN)-initiated and/or phenobarbital (Pb)-promoted HCC development ..
  70. ncbi Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia
    D Nayak
    Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Neuroscience 166:132-44. 2010
    ..the mouse BV2 microglial cells and SphK1 alters the expression and production of proinflammatory cytokines and nitric oxide in microglia treated with lipopolysaccharide (LPS)...
  71. ncbi Exhaled nitric oxide thresholds associated with a sputum eosinophil count ≥3% in a cohort of unselected patients with asthma
    Florence N Schleich
    Department of Pulmonary Medicine, CHU Sart Tilman, Liege, I GIGA Research Group, University of Liege, Belgium
    Thorax 65:1039-44. 2010
    It has been claimed that exhaled nitric oxide (FeNO) could be regarded as a surrogate marker for sputum eosinophil count in patients with asthma...
  72. ncbi Prehypertensive African-American women have preserved nitric oxide and renal function but high cardiovascular risk
    Deborah L Feairheller
    Hypertension, Molecular and Applied Physiology Laboratory, Department of Kinesiology, Temple University, Philadelphia, PA 19122, USA
    Kidney Blood Press Res 33:282-90. 2010
    ..The relationship between prehypertension, renal function, inflammation, and oxidative stress was examined...
  73. ncbi Heme oxygenase/carbon monoxide system participates in regulating wheat seed germination under osmotic stress involving the nitric oxide pathway
    Yahui Liu
    College of Life Sciences, Cooperative Demonstration Laboratory of Centrifuge Technique, Nanjing Agricultural University, Nanjing 210095, PR China
    J Plant Physiol 167:1371-9. 2010
    ..Exposure of wheat seeds to 25% PEG, HO-1 inhibitor or specific scavenger of nitric oxide (NO) alone differentially led to seed germination inhibition...
  74. ncbi The role of nitric oxide in the local antiallodynic and antihyperalgesic effects and expression of delta-opioid and cannabinoid-2 receptors during neuropathic pain in mice
    Arnau Hervera
    Grup de Neurofarmacologia Molecular, Institut de Recerca de l Hospital de la Sta Creu i Sant Pau and Institut de Neurociències, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Pharmacol Exp Ther 334:887-96. 2010
    ..We investigated whether nitric oxide synthesized by neuronal (NOS1) or inducible (NOS2) nitric-oxide synthases could modulate DOPr and/or CB2R ..
  75. ncbi Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension
    Patrick Crosswhite
    Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126 0901, USA
    J Hypertens 28:201-12. 2010
    ..Specifically, this review focuses on nitric oxide, oxidative stress and inflammation and how these factors contribute to the development and progression of PAH...
  76. ncbi Anaerobic metabolism occurs in the substratum of gonococcal biofilms and may be sustained in part by nitric oxide
    Megan L Falsetta
    Department of Microbiology, University of Iowa, 51 Newton Rd, BSB 3 403, Iowa City, IA 52242, USA
    Infect Immun 78:2320-8. 2010
    ..gonorrhoeae, using an aniA'-'gfp transcriptional fusion. Nitric oxide (NO) can elicit biofilm dispersal when present at sublethal concentrations in the surrounding medium...
  77. ncbi Morphine peripheral analgesia depends on activation of the PI3Kgamma/AKT/nNOS/NO/KATP signaling pathway
    Thiago M Cunha
    Department of Pharmacology, Faculty of Medicine, Ribeirão Preto University of São Paulo, Ribeirao Preto, 14049 900 Sao Paulo, Brazil
    Proc Natl Acad Sci U S A 107:4442-7. 2010
    ..of morphine is lost in neuronal nitric-oxide synthase null mice and that morphine induces the production of nitric oxide in primary nociceptive neurons...
  78. ncbi Diagnostic performance of an electronic nose, fractional exhaled nitric oxide, and lung function testing in asthma
    Paolo Montuschi
    Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Largo F Vito, 1, 00168 Rome, Italy
    Chest 137:790-6. 2010
    ..We compared the diagnostic performance of a prototype of an electronic nose with lung function tests and fractional exhaled nitric oxide (FENO) in patients with atopic asthma.
  79. ncbi Vascular endothelial growth factor receptor-1 modulates vascular endothelial growth factor-mediated angiogenesis via nitric oxide
    B Bussolati
    Department of Reproductive and Vascular Biology, The Medical School, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Am J Pathol 159:993-1008. 2001
    ..Here we report that VEGF-stimulated nitric oxide (NO) release is inhibited by blockade of VEGFR-1 and that VEGFR-1 via NO negatively regulates of VEGFR-2-..
  80. ncbi Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase
    Stephan Baldus
    Department of Cardiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Circulation 113:1871-8. 2006
    ..manner, and MPO binding to the vessel wall is a prerequisite for MPO-dependent oxidation of endothelium-derived nitric oxide (NO) and impairment of endothelial function in animal models...
  81. ncbi The demonstration of nitric oxide in cochlear blood vessels in vivo and in vitro: the role of endothelial nitric oxide in venular permeability
    Xiaorui Shi
    Oregon Hearing Research Center (NRC04, Department of Otolaryngology and Head and Neck Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201-3098, USA
    Hear Res 172:73-80. 2002
    ..Local perfusion of the cochlear basal turn with either Ringer's solution or Ringer's containing an inactive nitric oxide synthase inhibitor (100 microM) produced minimal protein leakage...
  82. ncbi Zeatin-induced nitric oxide (NO) biosynthesis in Arabidopsis thaliana mutants of NO biosynthesis and of two-component signaling genes
    Ni Ni Tun
    Universitat Hannover, Institut für Zierpflanzenbau und Gehölzforschung, Abt Molekulare, Ertragsphysiologie, Herrenhauser Strasse 2, D 30419 Hannover, Germany
    New Phytol 178:515-31. 2008
    Here, cytokinin-induced nitric oxide (NO) biosynthesis and cytokinin responses were investigated in Arabidopsis thaliana wild type and mutants defective in NO biosynthesis or cytokinin signaling components...
  83. ncbi Vascular endothelial growth factor and nitric oxide production in response to hypoxia in the choroid plexus in neonatal brain
    Viswanathan Sivakumar
    Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Brain Pathol 18:71-85. 2008
    ..mRNA and protein expression of hypoxia-inducible factor-1alpha (HIF-1alpha), endothelial, neuronal, inducible nitric oxide synthase (eNOS, nNOS, iNOS), and vascular endothelial growth factor (VEGF) along with nitric oxide (NO) ..
  84. ncbi Nitric oxide and its modulators in chronic constriction injury-induced neuropathic pain in rats
    Ajit K Naik
    Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar
    Eur J Pharmacol 530:59-69. 2006
    This study was conducted to examine the role of nitric oxide (NO) in peripheral neuropathy induced by chronic constriction injury of sciatic nerve of rats by using NO precursor, NO donors and nitric oxide synthase (NOS) inhibitors...
  85. ncbi Mechanism of transfer of NO from extracellular S-nitrosothiols into the cytosol by cell-surface protein disulfide isomerase
    N Ramachandran
    Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada
    Proc Natl Acad Sci U S A 98:9539-44. 2001
    ..Intracellular thiols may then be nitrosated by N2O3 at the membrane-cytosol interface...
  86. ncbi Concerted nitric oxide formation and release from the simultaneous reactions of nitrite with deoxy- and oxyhemoglobin
    Rozalina Grubina
    Vascular Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:12916-27. 2007
    ..studies reveal a novel role for hemoglobin as an allosterically regulated nitrite reductase that may mediate nitric oxide (NO)-dependent signaling along the physiological oxygen gradient...
  87. ncbi Effects of pu-erh tea on oxidative damage and nitric oxide scavenging
    Pin Der Duh
    Department of Food Science and Technology, Chia Nan University of Pharmacy and Science, 60 Erh Jen Road, Section 1, Pao An, Jen Te Hsiang, Tainan Hsien, Taiwan
    J Agric Food Chem 52:8169-76. 2004
    The effects of pu-erh tea, which is prepared by fermentation of tea, on oxidative damage and nitric oxide scavenging, compared with various other brands of tea were investigated...
  88. ncbi Vascular endothelial dysfunction: does tetrahydrobiopterin play a role?
    Z S Katusic
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Heart Circ Physiol 281:H981-6. 2001
    ..most potent naturally occurring reducing agents and an essential cofactor required for enzymatic activity of nitric oxide synthase (NOS)...
  89. ncbi Identification of a diacylglycerol acyltransferase gene involved in accumulation of triacylglycerol in Mycobacterium tuberculosis under stress
    Tatiana D Sirakova
    Biomolecular Science Center, and Department of Molecular Biology and Microbiology, Burnett College of Biomedical Sciences, University of Central Florida, Orlando, 32816 2364, USA
    Microbiology 152:2717-25. 2006
    ..If TG storage is needed for the long-term survival of M. tuberculosis under dormant conditions, the tgs1 product could be a suitable target for antilatency drugs...
  90. ncbi Enhanced nitric oxide inactivation and protein nitration by reactive oxygen species in renal insufficiency
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, CA 92868, USA
    Hypertension 39:135-41. 2002
    ..Reactive oxygen species (ROS) avidly reacts with nitric oxide (NO) producing cytotoxic reactive nitrogen species capable of nitrating proteins and damaging other molecules...
  91. ncbi In vivo electrophysiology of dopamine-denervated striatum: focus on the nitric oxide/cGMP signaling pathway
    Salvatore Galati
    Division of Neurology, Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    Synapse 62:409-20. 2008
    Within the striatum, the gaseous neurotransmitter nitric oxide (NO) is produced by a subclass of interneurons containing the neuronal NO synthase (nNOS)...
  92. ncbi Nitric oxide is involved in cadmium-induced programmed cell death in Arabidopsis suspension cultures
    Roberto De Michele
    Dipartimento di Biologia, Universita degli Studi di Padova, I 35131 Padova, Italy
    Plant Physiol 150:217-28. 2009
    ..CdCl(2) treatment was accompanied by a rapid increase in nitric oxide (NO) and phytochelatin synthesis, which continued to be high as long as cells remained viable...
  93. ncbi The Base Excision Repair system of Salmonella enterica serovar typhimurium counteracts DNA damage by host nitric oxide
    Anthony R Richardson
    Department of Laboratory Medicine, University of Washington, Seattle, WA, USA
    PLoS Pathog 5:e1000451. 2009
    Intracellular pathogens must withstand nitric oxide (NO.) generated by host phagocytes...
  94. ncbi Morphine induces apoptosis of human endothelial cells through nitric oxide and reactive oxygen species pathways
    Po Ni Hsiao
    Department of Anesthesiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Toxicology 256:83-91. 2009
    ..Morphine could induce apoptosis of HUVECs through both the NO and ROS pathways. Thus, inhibiting NO or ROS may be a potential target in blocking morphine-induced apoptosis of endothelial cells...
  95. ncbi Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation--a tale of three gases!
    Ling Li
    Pharmaceutical Science Division, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE19NH, UK
    Pharmacol Ther 123:386-400. 2009
    b>Nitric oxide (NO), carbon monoxide (CO) and hydrogen sulphide (H(2)S) together make up a family of biologically active gases (the so-called 'gaseous triumvirate') with an increasingly well defined range of physiological effects plus roles ..
  96. ncbi Nitric oxide regulates human sperm capacitation and protein-tyrosine phosphorylation in vitro
    M B Herrero
    Urology Research Laboratory, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada H3A 1A1
    Biol Reprod 61:575-81. 1999
    The aim of the present study was to investigate whether the generation of nitric oxide by human spermatozoa is associated with human sperm capacitation and with the tyrosine phosphorylation of sperm proteins...
  97. ncbi Thioredoxin reductase is essential for protection of Neisseria gonorrhoeae against killing by nitric oxide and for bacterial growth during interaction with cervical epithelial cells
    Adam J Potter
    Australian Bacterial Pathogenesis Program and Centre for Metals in Biology, School of Molecular and Microbial Sciences, University of Queensland, St Lucia, Australia
    J Infect Dis 199:227-35. 2009
    ..that it was more sensitive to disulfide stress and to stress induced by organic hydroperoxides, superoxide, and nitric oxide than wild-type gonococcus...
  98. ncbi Pure dietary flavonoids quercetin and (-)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men
    Wai Mun Loke
    School of Medicine and Pharmacology and the School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Perth, Western Australia
    Am J Clin Nutr 88:1018-25. 2008
    ..Dietary flavonoids may improve endothelial function and ultimately lead to beneficial cardiovascular effects...
  99. ncbi Reduction of renal mass is lethal in mice lacking vimentin. Role of endothelin-nitric oxide imbalance
    F Terzi
    INSERM U 380, Institut Cochin de Genetique Moleculaire, Paris, France
    J Clin Invest 100:1520-8. 1997
    ..Kidneys from Vim-/- mice synthesized more endothelin, but less nitric oxide (NO), than kidneys from normal animals...
  100. ncbi Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis
    Johanna Lahdenranta
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 69:2801-8. 2009
    ..However, the mechanistic understanding of lymphatic metastasis is still in infancy. Nitric oxide (NO) plays a crucial role in regulating blood vessel growth and function as well as lymphatic vessel function...
  101. ncbi Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene
    W Steudel
    Department of Anaesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Circ Res 81:34-41. 1997
    ..We conclude that NOS 3 is a key enzyme responsible for providing basal pulmonary NO release. Congenital NOS 3 deficiency produces mild pulmonary hypertension in mice...

Research Grants79

  1. Arginase and Regulation of Nitric Oxide Synthase in ALS
    Rajiv Ratan; Fiscal Year: 2004
    ..As nitric oxide (NO) has been shown to mediate neuronal loss in other neurodegenerative conditions, several groups have ..
  2. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    Christopher S Wilcox; Fiscal Year: 2010
    ..It is accompanied by increased reactive oxygen species (ROS) which can inactivate nitric oxide (NO). However, there is also an increase in asymmetric dimethylarginine (ADMA) which can inhibit NOS...
  3. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    Frances Walker; Fiscal Year: 2009
    ..The NPs are novel ferriheme proteins that are reversible carriers of nitric oxide (NO) and tight binders of histamine...
  4. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    Frances Walker; Fiscal Year: 2009
    ..The NPs are novel ferriheme proteins that are reversible carriers of nitric oxide (NO) and tight binders of histamine...
  5. Genetic Basis for Impaired Angiogenic Signaling in BPD
    STEVEN HERBERT ABMAN; Fiscal Year: 2010
    ..VEGF stimulates angiogenesis through upregulation of endothelial nitric oxide synthase (eNOS), which increases nitric oxide (NO) production...
  6. MANIPULATION OF PHAGOCYTOSIS IN MACROPHAGES
    Joel Swanson; Fiscal Year: 2003
    ..biochemical and fluorescence microscopic methods will be used to measure intravacuolar pH and intracellular nitric oxide levels. Sites of peroxynitrite generation will be localized in the cytopolasm and in individual phagosomes...
  7. HOMOCYST(E)INE, OXIDATIVE STRESS, AND NITRIC OXIDE
    Joseph Loscalzo; Fiscal Year: 2000
    ..microenvironment that leads to a state of endothelial dysfunction manifest by reduced production of bioactive nitric oxide. This effect is achieved by the formation of reactive oxygen species that react with and inactive nitric oxide, ..
  8. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    Frances Walker; Fiscal Year: 2006
    ..These heme proteins are novel Fe(lll) proteins that are reversible carriers of nitric oxide (NO) and tight binders of histamine...
  9. Nitric Oxide in Pulmonary Hypertension
    Serpil Erzurum; Fiscal Year: 2009
    ..The PAH cells have impaired production of the vasodilator nitric oxide (NO) due to post- translational mechanisms that include phosphorylation/inhibition of endothelial NO synthase (..
  10. Nitric Oxide Releasing Topical Gel for Burn Wound Healing
    ANJAL SHARMA; Fiscal Year: 2007
    b>Nitric oxide (NO) gas has been shown to play a significant role in the promotion and regulation of diverse wound healing processes, including burn wounds...
  11. Role of iNOS, Nitric Oxide & Arginase in Statin-Mediated Toxicity in Cancer Cells
    Balaraman Kalyanaraman; Fiscal Year: 2009
    ..statins cause increased cytotoxicity to breast cancer cells through either increased expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) and/or decreased arginase expression...
  12. VASCULAR ENDOTHELIUM ABNORMALITIES IN HEART FAILURE
    Stuart Katz; Fiscal Year: 1999
    ..Endothelial cell dysfunction appears to be characterized by decreased agonist-induced, endothelium-dependent, nitric oxide-mediated vasodilation and possibly increased release of the endothelium-derived vasoconstricting substance, ..
  13. Heme/Copper and Heme/Nonheme Iron O(2) and NO Reactivity
    KENNETH KARLIN; Fiscal Year: 2009
    ..ligation, spectroscopy and reactivity relevant to the chemistry utilized by heme-copper oxidases (HCOs) and nitric oxide reductases (NORs)...
  14. Heme/Copper and Heme/Nonheme Iron O(2) and NO Reactivity
    Kenneth D Karlin; Fiscal Year: 2010
    ..ligation, spectroscopy and reactivity relevant to the chemistry utilized by heme-copper oxidases (HCOs) and nitric oxide reductases (NORs)...
  15. NITRIC OXIDE INHIBITOR AND LEISHMANIA PATHOGENESIS
    MARION CHAN; Fiscal Year: 2004
    ..Current studies suggest that nitric oxide (NO) and peroxynitrite are crucial for elimination of the Leishmania parasites...
  16. Renal Control of Blood Pressure in Early Diabetes
    Michael Brands; Fiscal Year: 2007
    ..in diabetes causes significant renal vasoconstriction and hypertension if it occurs under conditions of chronic nitric oxide (NO) synthesis inhibition...
  17. TETRAHYDROBIOPTERIN--REGULATOR OF ENDOTHELIAL FUNCTION
    ZVONIMIR KATUSIC; Fiscal Year: 1999
    L-Arginine/nitric oxide pathway plays a key role in regulation of arterial tone. Biosynthesis of nitric oxide requires activation of nitric oxide synthase in the presence of tetrahydrobiopterin as a cofactor...
  18. Targeting Inflammation to Improve Endothelial Function in Type 2 Diabetes: A Subs
    Mark A Creager; Fiscal Year: 2010
    ..including type 2 diabetes mellitus, are associated with decreased bioavailability of endothelium-derived nitric oxide (NO) and impaired endothelium-dependent vasodilation, and impaired endothelial function predicts cardiovascular ..
  19. SUBSTANCE P, NO & MICROGLIA IN CNS INFLAMMATION
    Barnett Nathan; Fiscal Year: 2003
    ..next 5 years I plan to study in vitro and in vivo the interactions of microglia, macrophages, substance P and nitric oxide as well as the effect of these substances on mitochondrial function...
  20. Regulation of Endothelial Nitric Oxide Synthase mRNA stability
    Jianxin Sun; Fiscal Year: 2010
    b>Nitric oxide (NO), produced by endothelial nitric oxide synthase (eNOS), is critical to the maintenance of vascular homeostasis through promoting vasodilation and inhibiting vascular smooth muscle cells proliferation, platelets ..
  21. Inducible Nitric Oxide Synthase and Insulin Resistance
    Masao Kaneki; Fiscal Year: 2004
    ..resistance, including obesity and type 2 diabetes, are associated with increased expression of inducible nitric oxide synthase (iNOS) and oxidative stress...
  22. MEDIATORS OF PULMONARY VASODILATATION IN LIVER DISEASE
    Michael Fallon; Fiscal Year: 2003
    ..of chronic liver disease and is characterized by changes in the levels and activity of endothelial nitric oxide synthase...