nitric oxide

Summary

Summary: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.

Top Publications

  1. pmc Nitric oxide and peroxynitrite in health and disease
    Pal Pacher
    Section on Oxidative Stress Tissue Injury, Laboratory of Physiologic Studies, National Institutes of Health, National Institute of Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    Physiol Rev 87:315-424. 2007
  2. pmc Nitric oxide synthases: regulation and function
    Ulrich Förstermann
    Department of Pharmacology, Johannes Gutenberg University Medical Center, 55101 Mainz, Germany
    Eur Heart J 33:829-37, 837a-837d. 2012
  3. ncbi Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide
    Guangwen Ren
    Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 661 Hoes Lane, Piscataway, NJ 08854, USA
    Cell Stem Cell 2:141-50. 2008
  4. ncbi Nitric oxide and the immune response
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, Friedrich Alexander University of Erlangen Nuremberg, Wasserturmstrasse 3 5, D 91054 Erlangen, Germany
    Nat Immunol 2:907-16. 2001
  5. ncbi Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force
    Mary C Corretti
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland 21205 1595, USA
    J Am Coll Cardiol 39:257-65. 2002
  6. ncbi Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    S Dimmeler
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Nature 399:601-5. 1999
  7. ncbi Role of endothelial dysfunction in atherosclerosis
    Jean Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Ave W, Montreal, QC H2W 1R7, Canada
    Circulation 109:III27-32. 2004
  8. pmc Nitric oxide synthases: structure, function and inhibition
    W K Alderton
    In Vitro Pharmacology Department, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, UK
    Biochem J 357:593-615. 2001
  9. ncbi The L-arginine-nitric oxide pathway
    S Moncada
    Wellcome Research Laboratories, Beckenham, Kent, United Kingdom
    N Engl J Med 329:2002-12. 1993
  10. ncbi Endothelial nitric oxide synthase in vascular disease: from marvel to menace
    Ulrich Förstermann
    Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany
    Circulation 113:1708-14. 2006

Detail Information

Publications357 found, 100 shown here

  1. pmc Nitric oxide and peroxynitrite in health and disease
    Pal Pacher
    Section on Oxidative Stress Tissue Injury, Laboratory of Physiologic Studies, National Institutes of Health, National Institute of Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    Physiol Rev 87:315-424. 2007
    The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide (NO) has stimulated an extraordinary impetus for scientific research in all the fields of biology and medicine...
  2. pmc Nitric oxide synthases: regulation and function
    Ulrich Förstermann
    Department of Pharmacology, Johannes Gutenberg University Medical Center, 55101 Mainz, Germany
    Eur Heart J 33:829-37, 837a-837d. 2012
    b>Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of NO synthase (NOS; EC 1.14.13.39)...
  3. ncbi Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide
    Guangwen Ren
    Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 661 Hoes Lane, Piscataway, NJ 08854, USA
    Cell Stem Cell 2:141-50. 2008
    ..These cytokine combinations provoke the expression of high levels of several chemokines and inducible nitric oxide synthase (iNOS) by MSCs...
  4. ncbi Nitric oxide and the immune response
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, Friedrich Alexander University of Erlangen Nuremberg, Wasserturmstrasse 3 5, D 91054 Erlangen, Germany
    Nat Immunol 2:907-16. 2001
    During the past two decades, nitric oxide (NO) has been recognized as one of the most versatile players in the immune system...
  5. ncbi Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force
    Mary C Corretti
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland 21205 1595, USA
    J Am Coll Cardiol 39:257-65. 2002
    ..The technique provokes the release of nitric oxide, resulting in vasodilation that can be quantitated as an index of vasomotor function...
  6. ncbi Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    S Dimmeler
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Nature 399:601-5. 1999
    b>Nitric oxide (NO) produced by the endothelial NO synthase (eNOS) is a fundamental determinant of cardiovascular homesotasis: it regulates systemic blood pressure, vascular remodelling and angiogenesis...
  7. ncbi Role of endothelial dysfunction in atherosclerosis
    Jean Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Ave W, Montreal, QC H2W 1R7, Canada
    Circulation 109:III27-32. 2004
    ..Many of these effects are largely mediated by nitric oxide, the most potent endogenous vasodilator...
  8. pmc Nitric oxide synthases: structure, function and inhibition
    W K Alderton
    In Vitro Pharmacology Department, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, UK
    Biochem J 357:593-615. 2001
    This review concentrates on advances in nitric oxide synthase (NOS) structure, function and inhibition made in the last seven years, during which time substantial advances have been made in our understanding of this enzyme family...
  9. ncbi The L-arginine-nitric oxide pathway
    S Moncada
    Wellcome Research Laboratories, Beckenham, Kent, United Kingdom
    N Engl J Med 329:2002-12. 1993
  10. ncbi Endothelial nitric oxide synthase in vascular disease: from marvel to menace
    Ulrich Förstermann
    Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany
    Circulation 113:1708-14. 2006
    b>Nitric oxide (NO*) is an important protective molecule in the vasculature, and endothelial NO* synthase (eNOS) is responsible for most of the vascular NO* produced...
  11. pmc Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β
    Bibhuti B Mishra
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Immunol 14:52-60. 2013
    ..This effect was mediated by nitric oxide (NO), which we found specifically inhibited assembly of the NLRP3 inflammasome via thiol nitrosylation...
  12. ncbi Protein S-nitrosylation: purview and parameters
    Douglas T Hess
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Mol Cell Biol 6:150-66. 2005
    ..S-nitrosylation thereby conveys a large part of the ubiquitous influence of nitric oxide (NO) on cellular signal transduction, and provides a mechanism for redox-based physiological regulation.
  13. pmc Biochemical and functional characterization of three activated macrophage populations
    Justin P Edwards
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Leukoc Biol 80:1298-307. 2006
    ..These are sphingosine kinase-1 and LIGHT (TNF superfamily 14). Thus, Ca-Mphi, Mphi-II, and AA-Mphi represent three populations of cells with different biological functions...
  14. ncbi Nitric oxide and superoxide in inflammation and immune regulation
    T J Guzik
    Chair of Pharmacology, Jagiellonian University School of Medicine, Poland
    J Physiol Pharmacol 54:469-87. 2003
    b>Nitric oxide (NO) and reactive oxygen species exert multiple modulating effects on inflammation and play a key role in the regulation of immune responses. They affect virtually every step of the development of inflammation...
  15. pmc Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
    D Fulton
    Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Nature 399:597-601. 1999
    Endothelial nitric oxide synthase (eNOS) is the nitric oxide synthase isoform responsible for maintaining systemic blood pressure, vascular remodelling and angiogenesis...
  16. ncbi Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease
    Miriam M Cortese-Krott
    Cardiovascular Research Laboratory, Department of Cardiology, Pulmonology and Angiology, Heinrich Heine University of Dusseldorf, 40225 Dusseldorf, Germany
    Blood 120:4229-37. 2012
    A nitric oxide synthase (NOS)-like activity has been demonstrated in human red blood cells (RBCs), but doubts about its functional significance, isoform identity and disease relevance remain...
  17. pmc Protein S-nitrosylation in health and disease: a current perspective
    Matthew W Foster
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Trends Mol Med 15:391-404. 2009
    Protein S-nitrosylation constitutes a large part of the ubiquitous influence of nitric oxide on cellular signal transduction and accumulating evidence indicates important roles for S-nitrosylation both in normal physiology and in a broad ..
  18. pmc Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani
    H W Murray
    Department of Medicine, Division of Hematology Oncology, Cornell University Medical College, New York 10021, USA
    J Exp Med 189:741-6. 1999
    ..respiratory burst-deficient gp91(phox)-/- (X-linked chronic granulomatous disease [X-CGD]) mice and inducible nitric oxide synthase (iNOS) knockout (KO) mice displayed comparably increased susceptibility...
  19. ncbi Nitric oxide and oxidative stress in vascular disease
    Ulrich Förstermann
    Department of Pharmacology, Johannes Gutenberg University Medical Center, Obere Zahlbacher Strasse 67, 55101, Mainz, Germany
    Pflugers Arch 459:923-39. 2010
    Endothelium-derived nitric oxide (NO) is a paracrine factor that controls vascular tone, inhibits platelet function, prevents adhesion of leukocytes, and reduces proliferation of the intima...
  20. pmc cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action
    Sharron H Francis
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 2215 Garland Avenue, Nashville, TN 37232 0615, USA
    Pharmacol Rev 62:525-63. 2010
    To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by cyclic nucleotide phosphodiesterases (PDEs)...
  21. pmc Arginine metabolism: nitric oxide and beyond
    G Wu
    Departments of Animal Science, Medical Physiology, and Veterinary Anatomy and Public Health, and Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    Biochem J 336:1-17. 1998
    ..amino acids in animal cells, serving as a precursor for the synthesis not only of proteins but also of nitric oxide, urea, polyamines, proline, glutamate, creatine and agmatine...
  22. ncbi The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Nat Rev Drug Discov 7:156-67. 2008
    ..anions nitrate (NO3-) and nitrite (NO2-) were previously thought to be inert end products of endogenous nitric oxide (NO) metabolism...
  23. pmc Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation
    Matthias Totzeck
    Department of Medicine, Division of Cardiology, Pulmonology, and Vascular Medicine, University Hospital Duesseldorf, Germany
    Circulation 126:325-34. 2012
    ..We have shown that deoxygenated myoglobin in the heart can reduce nitrite to nitric oxide (NO·) and thereby contribute to cardiomyocyte NO· signaling during ischemia...
  24. ncbi S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration
    Takashi Uehara
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 441:513-7. 2006
    ..manifesting sporadic Parkinson's or Alzheimer's disease, that PDI is S-nitrosylated, a reaction transferring a nitric oxide (NO) group to a critical cysteine thiol to affect protein function...
  25. ncbi Adiponectin stimulates production of nitric oxide in vascular endothelial cells
    Hui Chen
    Diabetes Unit, Laboratory of Clinical Investigation, NCCAM, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:45021-6. 2003
    ..The vascular action of insulin to stimulate endothelial production of nitric oxide (NO), leading to vasodilation and increased blood flow is an important component of insulin-stimulated whole ..
  26. pmc Nitric oxide is required for root organogenesis
    Gabriela Carolina Pagnussat
    Instituto de Investigaciones Biologicas, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, 7600 Mar del Plata, Argentina
    Plant Physiol 129:954-6. 2002
  27. ncbi Molecular hydrogen inhibits lipopolysaccharide/interferon γ-induced nitric oxide production through modulation of signal transduction in macrophages
    Tomohiro Itoh
    Department of Longevity and Aging Research, Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Biochem Biophys Res Commun 411:143-9. 2011
    ..In the present study, we examined the hydrogen effects on lipopolysaccharide/interferon γ LPS/IFNγ-induced nitric oxide (NO) production in murine macrophage RAW264 cells...
  28. ncbi Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells
    Duk Hee Kang
    Division of Nephrology, Ewha Women s University Hospital, Seoul, Korea
    J Am Soc Nephrol 16:3553-62. 2005
    ..UA also increased HVSMC migration and inhibited HUVEC migration. In HUVEC, UA reduced nitric oxide (NO) release...
  29. ncbi ABA-induced NO generation and stomatal closure in Arabidopsis are dependent on H2O2 synthesis
    Jo Bright
    Centre for Research in Plant Science, Genomics Research Institute, University of the West of England, UWE, Bristol, Frenchay Campus, Coldharbour Lane, UK
    Plant J 45:113-22. 2006
    b>Nitric oxide (NO) and hydrogen peroxide (H(2)O(2)) are key signalling molecules produced in response to various stimuli and involved in a diverse range of plant signal transduction processes...
  30. pmc Arginase: a critical regulator of nitric oxide synthesis and vascular function
    William Durante
    Department of Medical Pharmacology and Physiology, University of Missouri Columbia, Columbia, Missouri 65212, USA
    Clin Exp Pharmacol Physiol 34:906-11. 2007
    ..studies have identified arginase in the vasculature and have implicated this enzyme in the regulation of nitric oxide (NO) synthesis and the development of vascular disease. 2...
  31. pmc Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock
    Kairui Mao
    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Cell Res 23:201-12. 2013
    ..Here we show that nitric oxide (NO) inhibited the NLRP3-mediated ASC pyroptosome formation, caspase-1 activation and IL-1β secretion in ..
  32. pmc miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production
    Ana L Cardoso
    Centre for Neuroscience and Cell Biology, University of Coimbra, Portugal
    Immunology 135:73-88. 2012
    ..oligonucleotides up-regulated SOCS-1 mRNA and protein levels and significantly decreased the production of nitric oxide and the expression of inflammatory cytokines and inducible nitric oxide synthase...
  33. ncbi Roles of hydrogen sulfide and nitric oxide in the alleviation of cadmium-induced oxidative damage in alfalfa seedling roots
    Le Li
    College of Life Sciences, Cooperative Demonstration Laboratory of Centrifuge Technique of Nanjing Agricultural University and Beckman Coulter Ltd Co, Nanjing 210095, People s Republic of China
    Biometals 25:617-31. 2012
    Despite hydrogen sulfide (H(2)S) and nitric oxide (NO) are important endogenous signals or bioregulators involved in many vital aspects of plant growth and responses against abiotic stresses, little information was known about their ..
  34. pmc Concepts of neural nitric oxide-mediated transmission
    John Garthwaite
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WCIE 6BT, UK
    Eur J Neurosci 27:2783-802. 2008
    As a chemical transmitter in the mammalian central nervous system, nitric oxide (NO) is still thought a bit of an oddity, yet this role extends back to the beginnings of the evolution of the nervous system, predating many of the more ..
  35. ncbi Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
    Kenyatta Cosby
    Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 7B15 Bethesda, Maryland 20892, USA
    Nat Med 9:1498-505. 2003
    Nitrite anions comprise the largest vascular storage pool of nitric oxide (NO), provided that physiological mechanisms exist to reduce nitrite to NO...
  36. ncbi Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide
    Enzo Nisoli
    Department of Preclinical Sciences, Center for Study and Research on Obesity, Luigi Sacco Hospital, University of Milan, Milan 20157, Italy
    Science 299:896-9. 2003
    b>Nitric oxide was found to trigger mitochondrial biogenesis in cells as diverse as brown adipocytes and 3T3-L1, U937, and HeLa cells...
  37. ncbi β Common receptor integrates the erythropoietin signaling in activation of endothelial nitric oxide synthase
    Kuo Hui Su
    Department of Physiology, National Yang Ming University, Taipei, Taiwan
    J Cell Physiol 226:3330-9. 2011
    Erythropoietin (EPO), the key hormone for erythropoiesis, also increases nitric oxide (NO) bioavailability in endothelial cells (ECs), yet the definitive mechanisms are not fully understood...
  38. ncbi Nitric oxide signaling in brain function, dysfunction, and dementia
    Joern R Steinert
    Neurotoxicity at the Synaptic Interface, MRC Toxicology Unit, University of Leicester, Leicester, UK
    Neuroscientist 16:435-52. 2010
    b>Nitric oxide (NO) is an important signaling molecule that is widely used in the nervous system...
  39. pmc Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes
    Veronika Lukacs-Kornek
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Nat Immunol 12:1096-104. 2011
    ..we report that FRCs and LECs inhibited T cell proliferation through a tightly regulated mechanism dependent on nitric oxide synthase 2 (NOS2)...
  40. ncbi Nitric oxide signaling: classical, less classical, and nonclassical mechanisms
    Antonio Martínez-Ruiz
    Servicio de Inmunologia, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa IP, Madrid, Spain
    Free Radic Biol Med 51:17-29. 2011
    Although nitric oxide (NO) was identified more than 150 years ago and its effects were clinically tested in the form of nitroglycerine, it was not until the decades of 1970-1990 that it was described as a gaseous signal transducer...
  41. ncbi Phylogenetic analysis of nitrite, nitric oxide, and nitrous oxide respiratory enzymes reveal a complex evolutionary history for denitrification
    Christopher M Jones
    Department of Microbiology, Swedish Agricultural University, Uppsala, Sweden
    Mol Biol Evol 25:1955-66. 2008
    Denitrification is a facultative respiratory pathway in which nitrite (NO2(-)), nitric oxide (NO), and nitrous oxide (N2O) are successively reduced to nitrogen gas (N(2)), effectively closing the nitrogen cycle...
  42. ncbi Nitric oxide, stomatal closure, and abiotic stress
    Steven Neill
    Centre for Research in Plant Science, Faculty of Health and Life Sciences, University of the West of England, Bristol BS16 1QY, UK
    J Exp Bot 59:165-76. 2008
    Various data indicate that nitric oxide (NO) is an endogenous signal in plants that mediates responses to several stimuli...
  43. ncbi High glucose impairs early and late endothelial progenitor cells by modifying nitric oxide-related but not oxidative stress-mediated mechanisms
    Yung Hsiang Chen
    School of Medicine, National Yang Ming University, Taipei City, Taiwan
    Diabetes 56:1559-68. 2007
    ..Endothelial progenitor cells (EPCs) are impaired in diabetes. This study aimed to investigate the direct effects of high glucose on EPCs...
  44. ncbi The role of nitric oxide in tumour progression
    Dai Fukumura
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Rev Cancer 6:521-34. 2006
    b>Nitric oxide (NO) and nitric oxide synthases are ubiquitous in malignant tumours and are known to exert both pro- and anti-tumour effects...
  45. pmc Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells
    Nikki Charles
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cell Stem Cell 6:141-52. 2010
    ..We investigated the potential role of nitric oxide (NO) activity in the perivascular niche (PVN) using a genetic engineered mouse model of PDGF-induced gliomas...
  46. ncbi Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
    D K Dalton
    Genentech Inc, South San Francisco, CA 94080
    Science 259:1739-42. 1993
    ..Resting splenic natural killer cell activity was reduced in IFN-gamma-deficient mice. Thus, IFN-gamma is essential for the function of several cell types of the murine immune system...
  47. ncbi Role of nitric oxide in the regulation of digital pulse volume amplitude in humans
    Anju Nohria
    Cardiovascular Div, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    J Appl Physiol (1985) 101:545-8. 2006
    ..PVA) during reactive hyperemia relative to baseline (PVA-RH) is being applied widely as a convenient test of nitric oxide bioavailability. However, evidence linking digital PVA-RH to nitric oxide is currently lacking...
  48. pmc Nitric oxide-mediated regulation of β-amyloid clearance via alterations of MMP-9/TIMP-1
    Lisa A Ridnour
    Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    J Neurochem 123:736-49. 2012
    ..Regulation of MMP-9 and its endogenous inhibitor tissue inhibitor of metalloproteinase (TIMP)-1 by nitric oxide (NO) has been shown...
  49. ncbi Hydrogen peroxide and nitric oxide as signalling molecules in plants
    Steven J Neill
    Centre for Research in Plant Science, Faculty of Applied Sciences, University of the West of England, Coldharbour Lane, Bristol BS16 1QY, UK
    J Exp Bot 53:1237-47. 2002
    It is now clear that hydrogen peroxide (H(2)O(2)) and nitric oxide (NO) function as signalling molecules in plants. A wide range of abiotic and biotic stresses results in H(2)O(2) generation, from a variety of sources...
  50. ncbi Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation
    Mark T Gladwin
    Vascular Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
    Am J Physiol Heart Circ Physiol 291:H2026-35. 2006
    ..salt, nitrite (NO(2)(-)), is a physiological signaling molecule with potential roles in intravascular endocrine nitric oxide (NO) transport, hypoxic vasodilation, signaling, and cytoprotection after ischemia-reperfusion...
  51. pmc Nitric oxide influences auxin signaling through S-nitrosylation of the Arabidopsis TRANSPORT INHIBITOR RESPONSE 1 auxin receptor
    María C Terrile
    Instituto de Investigaciones Biologicas, UE CONICET UNMDP, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Funes 3250, CC 1245, 7600 Mar del Plata, Argentina
    Plant J 70:492-500. 2012
    Previous studies have demonstrated that auxin (indole-3-acetic acid) and nitric oxide (NO) are plant growth regulators that coordinate several plant physiological responses determining root architecture...
  52. ncbi On the origins of nitric oxide
    Kapuganti J Gupta
    Energy Metabolism Research Group, Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
    Trends Plant Sci 16:160-8. 2011
    b>Nitric oxide (NO) is widely recognized for its role as signaling compound...
  53. pmc Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation
    Ciro Coletta
    Department of Anesthesiology, University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, TX 77555, USA
    Proc Natl Acad Sci U S A 109:9161-6. 2012
    ..vascular actions of H(2)S (stimulation of angiogenesis, relaxation of vascular smooth muscle) resemble those of nitric oxide (NO)...
  54. ncbi The role of nitric oxide in innate immunity
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Germany
    Immunol Rev 173:17-26. 2000
    Type 2 nitric oxide synthase (iNOS or NOS2) was originally described as an enzyme that is expressed in activated macrophages, generates nitric oxide (NO) from the amino acid L-arginine, and thereby contributes to the control of ..
  55. ncbi Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: progress, pitfalls, and prospects
    Peter Wardman
    University of Oxford, Gray Cancer Institute, Mount Vernon Hospital, Northwood, Middlesex HA6 2JR, UK
    Free Radic Biol Med 43:995-1022. 2007
    ..species include hydrogen peroxide; hydroxyl, superoxide, and thiyl radicals; carbonate radical-anion; and nitric oxide, nitrogen dioxide, and peroxynitrite...
  56. ncbi Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration
    Sruti Shiva
    Vascular Medicine Branch, Clinical Center National Institutes of Health, Bethesda, MD 20892 1662, USA
    Circ Res 100:654-61. 2007
    Previous studies have revealed a novel interaction between deoxyhemoglobin and nitrite to generate nitric oxide (NO) in blood...
  57. ncbi Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial
    Heather Powell
    Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia
    Lancet 378:983-90. 2011
    ..counts reduce exacerbations in non-pregnant women with asthma, but results with the fraction of exhaled nitric oxide (F(E)NO) to guide management are equivocal...
  58. pmc PGC-1α promotes nitric oxide antioxidant defenses and inhibits FOXO signaling against cardiac cachexia in mice
    Tuoyu Geng
    Department of Medicine Cardiovascular Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Am J Pathol 178:1738-48. 2011
    ..kinase B expression, in glycolytic muscles, PGC-1α overexpression led to enhanced expression of inducible nitric oxide synthase and endothelial nitric oxide synthase, production of nitric oxide, and expression of antioxidant ..
  59. ncbi Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxide
    Ivraym B Barsoum
    Department of Anatomy and Cell Biology, Queen s University, Kingston, Ontario, Canada
    Cancer Res 71:7433-41. 2011
    ..b>Nitric oxide mimetic agents interfered with the hypoxia-induced accumulation of HIF-1α and with the hypoxia-induced ..
  60. ncbi Connecting the chemical and biological properties of nitric oxide
    José Carlos Toledo
    Departamento de Quimica, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
    Chem Res Toxicol 25:975-89. 2012
    b>Nitric oxide (NO(•); nitrogen monoxide) is known to be a critical regulator of cell and tissue function through mechanisms that utilize its unique physicochemical properties as a small and uncharged free radical with limited reactivity...
  61. ncbi Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB
    Maristela Lika Onozato
    Division of Nephrology and Endocrinology, University of Tokyo, Tokyo, Japan
    Kidney Int 61:186-94. 2002
    ..adenine dinucleotide phosphate [NAD(P)H] oxidase, whose product superoxide anion (O2-) can interact with nitric oxide (NO) to form peroxynitrite (ONOO-)...
  62. pmc Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species
    Brian P Dranka
    Department of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, 35294, USA
    Free Radic Biol Med 48:905-14. 2010
    ..These data are consistent with a critical role for the mitochondrial reserve capacity in endothelial cells in responding to oxidative stress...
  63. ncbi Nitric oxide and neuronal death
    Guy C Brown
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, United Kingdom
    Nitric Oxide 23:153-65. 2010
    ..iNOS is induced in glia by inflammation, and may protect; however, if there is also hypoxia or the NADPH oxidase is active, it can induce neuronal death. Microglial phagocytosis may contribute actively to neuronal loss...
  64. ncbi Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation
    Peter F Mount
    Department of Nephrology, Austin Health, Studley Road, Heidelberg 3084, Victoria, Australia
    J Mol Cell Cardiol 42:271-9. 2007
    The controlled regulation of nitric oxide (NO) synthesis in endothelial cells and cardiomyocytes by the endothelial form of nitric oxide synthase (eNOS or NOS3) is essential for cardiovascular health...
  65. ncbi Intake of red wine increases the number and functional capacity of circulating endothelial progenitor cells by enhancing nitric oxide bioavailability
    Po Hsun Huang
    Division of Cardiology, Taipei Veterans General Hospital, Taipei, Taiwan
    Arterioscler Thromb Vasc Biol 30:869-77. 2010
    ..This study tested the hypothesis that intake of RW may promote the circulating endothelial progenitor cell (EPC) level and function through enhancement of nitric oxide bioavailability.
  66. ncbi High-yield isolation of murine microglia by mild trypsinization
    Josep Saura
    Department of Pharmacology and Toxicology, Institut d Investigacions Biomediques de Barcelona, IIBB CSIC, Barcelona, Spain
    Glia 44:183-9. 2003
    ..Because of its high yield, it can be especially convenient when high amounts of microglial protein/mRNA are required or in cases in which the starting material is limited, such as microglial cultures from transgenic animals...
  67. ncbi Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital OX3 9DU, Oxford, UK
    Circulation 124:335-45. 2011
    ..We examined the direct effects of atorvastatin on tetrahydrobiopterin-mediated endothelial nitric oxide (NO) synthase coupling in patients with coronary artery disease.
  68. pmc Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase
    Barbara Wegiel
    Transplant Institute, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 108:18849-54. 2011
    ..BV) quells the cellular response to endotoxin-induced inflammation through phosphorylation of endothelial nitric oxide synthase (eNOS)...
  69. ncbi S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding
    Makoto R Hara
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nat Cell Biol 7:665-74. 2005
    ..Here we report a signalling pathway in which nitric oxide (NO) generation that follows apoptotic stimulation elicits S-nitrosylation of GAPDH, which triggers binding to ..
  70. ncbi Methods of nitric oxide detection in plants: a commentary
    Luis A J Mur
    University of Wales, Aberystwyth, Institute of Biological Sciences, Aberystwyth, Wales, UK
    Plant Sci 181:509-19. 2011
    Over the last decade nitric oxide (NO) has been shown to influence a range of processes in plants. However, when, where and even if NO production occurs is controversial in several physiological scenarios in plants...
  71. ncbi Reactive oxygen species, antioxidant systems and nitric oxide in peroxisomes
    Luis A del Rio
    Departamento de Bioquimica, Biologia Celular y Molecular de Plantas, Estacion Experimental del Zaidin, CSIC, Apartado 419, E 18080 Granada, Spain
    J Exp Bot 53:1255-72. 2002
    ..for peroxisomes related to reactive oxygen species (ROS), but the recent demonstration of the presence of nitric oxide synthase (NOS) in plant peroxisomes implies that these organelles could also have a function in plant cells as ..
  72. ncbi Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide production
    Yeon Sook Choi
    Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea
    Blood 114:3117-26. 2009
    ..Ligation of IL-33 with ST2 rapidly increased endothelial nitric oxide (NO) production through TRAF6-mediated activation of phosphoinoside-3-kinase, Akt, and endothelial NO synthase...
  73. ncbi Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Erlangen, D 91054, Germany
    Curr Opin Immunol 12:64-76. 2000
    b>Nitric oxide, nitric oxide derivatives and reactive oxygen intermediates are toxic molecules of the immune system which contribute to the control of microbial pathogens and tumors...
  74. ncbi Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase
    Z Huang
    Stroke Research Laboratory, Massachusetts General Hospital, Charlestown 02129
    Science 265:1883-5. 1994
    The proposal that nitric oxide (NO) or its reactant products mediate toxicity in brain remains controversial in part because of the use of nonselective agents that block NO formation in neuronal, glial, and vascular compartments...
  75. pmc Nitric oxide, oxidants, and protein tyrosine nitration
    Rafael Radi
    Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, Avda General Flores 2125, 11800 Montevideo, Uruguay
    Proc Natl Acad Sci U S A 101:4003-8. 2004
    ....
  76. pmc Plasma sodium stiffens vascular endothelium and reduces nitric oxide release
    Hans Oberleithner
    Institute of Physiology II and Department of Internal Medicine D, University of Munster, 48149 Munster, Germany
    Proc Natl Acad Sci U S A 104:16281-6. 2007
    ..b>Nitric oxide formation was found down-regulated in cells cultured in aldosterone-containing high sodium medium...
  77. ncbi The hamster as a model of human visceral leishmaniasis: progressive disease and impaired generation of nitric oxide in the face of a prominent Th1-like cytokine response
    P C Melby
    Medical Service, Department of Veterans Affairs Medical Center, South Texas Veterans Health Care System, San Antonio, TX 78284, USA
    J Immunol 166:1912-20. 2001
    ..Thus, although a Th1-like cytokine response was prominent, the major antileishmanial effector mechanism that is responsible for control of infection in mice was absent throughout the course of progressive VL in the hamster...
  78. ncbi Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase
    G C Brown
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK
    Biochim Biophys Acta 1504:46-57. 2001
    b>Nitric oxide (NO) and its derivatives inhibit mitochondrial respiration by a variety of means...
  79. ncbi Production of nitric oxide by glial cells: regulation and potential roles in the CNS
    S Murphy
    Department of Pharmacology and the Neuroscience Program, University of Iowa College of Medicine, Iowa City, USA
    Glia 29:1-13. 2000
    Roles proposed for nitric oxide (NO) in CNS pathophysiology are increasingly diverse and range from intercellular signaling, through necrotic killing of cells and invading pathogens, to the involvement of NO in apoptosis and tissue ..
  80. pmc Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats
    Jae Hyung Kim
    Anesthesiology, Tower 711, Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21287, USA
    J Appl Physiol (1985) 107:1249-57. 2009
    ..In this study, we demonstrate that arginase upregulation leads to endothelial nitric oxide synthase (eNOS) uncoupling and that in vivo chronic inhibition of arginase restores nitroso-redox balance, ..
  81. ncbi Endothelial function: a critical determinant in atherosclerosis?
    Ulf Landmesser
    Medizinische Hochschule Hannover, Abteilung Kardiologie und Angiologie, Carl Neuberg Str 1, 30625 Hannover, Germany
    Circulation 109:II27-33. 2004
    ..An important rationale for this approach has been the observation that endothelium-derived nitric oxide (NO), a major mediator of endothelium-dependent vasodilation, has important anti-inflammatory and ..
  82. ncbi A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Toronto, Canada
    Circulation 106:913-9. 2002
    Given the central importance of nitric oxide (NO) in the development and clinical course of cardiovascular diseases, we sought to determine whether the powerful predictive value of C-reactive protein (CRP) might be explained through an ..
  83. ncbi Mechanisms underlying endothelial dysfunction in diabetes mellitus
    U Hink
    Universitatskrankenhaus Eppendorf, Germany
    Circ Res 88:E14-22. 2001
    ..endothelial cells in vitro with high concentrations of glucose activates protein kinase C (PKC) and increases nitric oxide synthase (NOS III) gene expression as well as superoxide production. The underlying mechanisms remain unknown...
  84. ncbi Globular adiponectin improves high glucose-suppressed endothelial progenitor cell function through endothelial nitric oxide synthase dependent mechanisms
    Po Hsun Huang
    Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    J Mol Cell Cardiol 51:109-19. 2011
    ..that globular adiponectin can improve high glucose-suppressed EPC functions by restoration of endothelial nitric oxide synthase (eNOS) activity. Late EPCs isolated from healthy subjects appeared with cobblestone shape at 2-4 weeks...
  85. ncbi Dose-dependent modulatory effects of insulin on glucose-induced endothelial senescence in vitro and in vivo: a relationship between telomeres and nitric oxide
    Hisako Matsui-Hirai
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Pharmacol Exp Ther 337:591-9. 2011
    ..of insulin under high-glucose conditions was associated with reduced reactive oxygen species and increased nitric oxide (NO). Small interfering RNA targeting endothelial NO synthase reduced the antisenescence effects of insulin...
  86. pmc Nitric reductase-dependent nitric oxide production is involved in cold acclimation and freezing tolerance in Arabidopsis
    Min Gui Zhao
    State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, People s Republic of China
    Plant Physiol 151:755-67. 2009
    b>Nitric oxide (NO) is an important signaling molecule involved in many physiological processes in plants...
  87. ncbi Nitric oxide: role in tumour biology and iNOS/NO-based anticancer therapies
    Simendra Singh
    Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, Gautam Budha Nagar 201306, India
    Cancer Chemother Pharmacol 67:1211-24. 2011
    The diatomic radical nitric oxide (NO) has been the cause of intense debate with implication in carcinogenesis, tumour progression, invasion, angiogenesis and modulation of therapeutic responses...
  88. pmc eNOS, metabolic syndrome and cardiovascular disease
    Paul L Huang
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Trends Endocrinol Metab 20:295-302. 2009
    ..This review focuses on endothelial nitric oxide synthase and summarizes evidence that a reduction in the bioavailability of endothelium-derived nitric oxide ..
  89. pmc Effect of exercise training on endothelium-derived nitric oxide function in humans
    Daniel J Green
    School of Human Movement and Exercise Science, University of Western Australia, Mailbag Delivery M408, 35 Stirling Highway, Crawley WA 6009, Australia
    J Physiol 561:1-25. 2004
    ..These functions are due to the production of numerous autacoids, of which nitric oxide (NO) has been the most widely studied...
  90. ncbi Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide
    Gi Su Oh
    Department of Microbiology and Immunology and Medicinal Resources Research Institute, Wonkwang University School of Medicine, Iksan, Chonbuk 570 749, Republic of Korea
    Free Radic Biol Med 41:106-19. 2006
    ..beta-synthase (CBS) from L-cysteine (L-Cys) metabolism, is a putative vasodilator, and its role in nitric oxide (NO) production is unexplored...
  91. pmc Redox regulation of the NPR1-TGA1 system of Arabidopsis thaliana by nitric oxide
    Christian Lindermayr
    Institute of Biochemical Plant Pathology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, D 85764 Neuherberg, Germany
    Plant Cell 22:2894-907. 2010
    ..Here, we report the effect of the physiological nitric oxide donor S-nitrosoglutathione on the NPR1/TGA1 regulation system in Arabidopsis thaliana...
  92. pmc The chemical biology of nitric oxide: implications in cellular signaling
    Douglas D Thomas
    Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Free Radic Biol Med 45:18-31. 2008
    b>Nitric oxide (NO) has earned the reputation of being a signaling mediator with many diverse and often opposing biological activities...
  93. pmc Amorphous silica nanoparticles trigger nitric oxide/peroxynitrite imbalance in human endothelial cells: inflammatory and cytotoxic effects
    J Jose Corbalan
    School of Pharmacy and Pharmaceutical Sciences, Faculty of Health Sciences, Panoz Institute, Trinity College Dublin, Dublin, Ireland
    Int J Nanomedicine 6:2821-35. 2011
    ..The purpose of this study was to investigate the mechanism of noxious effects of amorphous silica nanoparticles on human endothelial cells...
  94. ncbi Flow-mediated dilation and cardiovascular event prediction: does nitric oxide matter?
    Daniel J Green
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool L3 3AF, UK
    Hypertension 57:363-9. 2011
    ..been assumed that this association is related to the proposal that FMD provides an index of endothelium-derived nitric oxide (NO) function...
  95. pmc Complex inhibitory effects of nitric oxide on autophagy
    Sovan Sarkar
    Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0XY, UK
    Mol Cell 43:19-32. 2011
    ..Several autophagy regulators have been identified in recent years. Here we show that nitric oxide (NO), a potent cellular messenger, inhibits autophagosome synthesis via a number of mechanisms...
  96. ncbi Aged garlic extract enhances production of nitric oxide
    Naoaki Morihara
    Healthcare Research Institute, Wakunaga Pharmaceutical Co Ltd, 1624 Shimokotachi, Kodacho Takatagun, 739 1195, Hiroshima, Japan
    Life Sci 71:509-17. 2002
    b>Nitric oxide (NO) controls several physiological functions of the cardiovascular system...
  97. pmc Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation
    N A Riobo
    Laboratory of Oxygen Metabolism, University Hospital, University of Buenos Aires, Cordoba 2351, 1120, Buenos Aires, Argentina
    Biochem J 359:139-45. 2001
    ..Inhibition of Complex I activity by peroxynitrite may have critical implications for energy supply in tissues such as the brain, whose mitochondrial function depends largely on the channelling of reducing equivalents through Complex I...
  98. ncbi Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A
    Anthony R Smith
    Linus Pauling Institute and Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA
    Aging Cell 5:391-400. 2006
    ..that post-translational signaling pathways become disrupted with age and adversely affect endothelial nitric oxide synthase (eNOS) activity and endothelial-derived nitric oxide (NO) production...
  99. pmc Cellular signaling and NO production
    Thomas Michel
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Pflugers Arch 459:807-16. 2010
    ..The best characterized endothelium-derived relaxing factor is nitric oxide (NO), which is synthesized by the endothelial isoform of nitric oxide synthase (eNOS)...
  100. ncbi Mitochondrial generation of free radicals and hypoxic signaling
    Robert O Poyton
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Trends Endocrinol Metab 20:332-40. 2009
    ..Recently, it has become clear that under hypoxic conditions, the mitochondrial respiratory chain also produces nitric oxide (NO), which can generate other reactive nitrogen species (RNS)...
  101. pmc Candidate pathways linking inducible nitric oxide synthase to a basal-like transcription pattern and tumor progression in human breast cancer
    Stefan Ambs
    Laboratory of Human Carcinogenesis, Center for Cancer Research CCR, National Cancer Institute NCI Bethesda, MD USA
    Cell Cycle 10:619-24. 2011
    Inducible nitric oxide synthase (NOS2) is an inflammation responsive enzyme (EC 1.14.13.39) that is induced during acute and chronic inflammation and tissue injury as part of the host defense and wound healing process...

Research Grants70

  1. Iron-mediated vascular disease in sickle cell disease.
    John C Wood; Fiscal Year: 2010
    ..which releases red cell components in the circulation, is a leading cause of vasculopathy and acts by impairing nitric oxide bioavailability...
  2. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..CST transiently stimulates gluconeogenesis by attenuating endothelial nitric oxide synthase (eNOS) and 5'-adenosine monophosphate-activated protein kinase (AMPK), and enhances glucose ..
  3. Angiotensin Adrenergic Interactions in the Kidney
    Roland C Blantz; Fiscal Year: 2013
    ..A/I kidney including NADPH oxidase, heme-oxygenase-1 (HO-1),, and ERK 1/2 phosphorylation and functional nitric oxide activity was decreased...
  4. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Alterations in the biosynthesis of the free radicals nitric oxide (NO) and superoxide anion are generally accepted to contribute to widespread tissue injury in sepsis via their induction of ..
  5. Ang II and Aldosterone Effects on Insulin Resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..employ direct visualization of skeletal muscle arterioles using video microscopy to evaluate insulin induced nitric oxide dependent vasodilation...
  6. Roles of Nitric Oxide and Superoxide in Cystitis
    ANTHONY JOHN KANAI; Fiscal Year: 2013
    ..During the first grant period, we used nitric oxide (NO*), nitrite (NO2-) and peroxynitrite (ONO2-) microsensors along with Ca2+ imaging to determine that ..
  7. Ang II and Overnutrition and Insulin resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..ANG II in CV tissue leading to diminished INS metabolic signaling and biological consequences, such as impaired nitric oxide (NO)-mediated vascular relaxation...
  8. The influence of air pollution mixtures on biomarkers of airway oxidative stress
    Roby Greenwald; Fiscal Year: 2013
    ..Before and after athletic practice sessions, they will conduct pulmonary function tests, measure exhaled nitric oxide, and collect samples of exhaled breath condensate for analysis of markers of oxidative stress and lipid ..
  9. Preclinical Development of JS-K, a Novel NO-Generating Prodrug for Cancer
    Paul J Shami; Fiscal Year: 2012
    ..b>Nitric oxide (NO) is well known to kill cancer cells without harming normal bone marrow cells, but until now has not been ..
  10. Alternative Macrophage Activation Limits Immunopathology
    DEBROSKI R HERBERT; Fiscal Year: 2011
    ..g., TNF, IL-12, IL-23) and nitric oxide (NO) that, together, drive potent anti-microbial functions...
  11. Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground Mi
    Jefferey L Burgess; Fiscal Year: 2013
    ..Urinary 8- hydroxy-2'-deoxyguanosine (8-OHdG) will be assayed to assess oxidative DNA damage. Exhaled nitric oxide (NO), a marker of airway inflammation, and exhaled carbon monoxide (CO), a marker of CO exposure will both be ..
  12. Neural mechanisms by which chronic stress regulates inflammation in asthma
    Melissa A Rosenkranz; Fiscal Year: 2013
    ..examined in relation to measures of lung function (FEV1), inflammation (sputum and blood eosinophils, exhaled nitric oxide), sensitivity of immune cells to inhibition by glucocorticoids, stress responsivity (salivary cortisol and ..
  13. Novel Peptide MPO Inhibitors for Treating Atherosclerosis
    Kirkwood A Pritchard; Fiscal Year: 2012
    ..MPO catalytically consumes nitric oxide ([unreadable]NO) and converts it to nitrite (NO2-)...
  14. Targeting iNOS to inhibit myeloid-derived suppressor cells (MDSC) in melanoma
    ANDREW GREGORY SIKORA; Fiscal Year: 2013
    ..and potently inhibit anti-tumor T cell responses through a variety of mechanisms including production of nitric oxide (NO) by inducible nitric oxide synthase (iNOS)...
  15. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2013
    ..Activation of NADPH oxidase and uncoupled activity of endothelial nitric oxide synthase (eNOS) are sources of superoxide (O2[unreadable]-) in the pulmonary arteries in PPHN...
  16. Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular Function
    ANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010
    ..activation of fibroblasts, insulin resistance, dyslipidemia, fat deposition and down regulation of endothelial nitric oxide - all of which plausibly contribute to elevated blood pressure (BP)and vascular and pressure- sensitive target ..
  17. Conference on Autonomic Regulation of Cardiovascular Function in Health and Disea
    Martin Frank; Fiscal Year: 2012
    ..g. the hypothalamus and medulla). Symposia and poster presentations will focus on reactive oxidant stress, nitric oxide, angiotensin II, angiotensn (1-7), glutamate, GABA and the transcriptional and translational regulation of the ..
  18. Expression of sFlt1 and its function in the glomerular endothelium
    Christie P Thomas; Fiscal Year: 2013
    ..We hypothesize that sFlt1 inhibits glomerular endothelial nitric oxide synthase (eNOS) and NO release which in turn increases ET-1 expression and release from GEC...
  19. Analysis of gene regulation of Vibrio cholerae during infection
    Jun Zhu; Fiscal Year: 2013
    ..Next we will examine how AphB is modified by reactive nitrogen species (RNS), such as nitric oxide (NO), and oxidative stress from reactive oxygen species (ROS) generated in vivo and how these modifications ..
  20. Nitric Oxide in Hemodialysis AV Fistula Maturation
    Richard A Cohen; Fiscal Year: 2010
    ..Oxidative stress and reduced nitric oxide (NO) bioavailability are important contributors to the accelerated vascular disease that accompanies ESRD, and ..
  21. Nitric Oxide Restoration &Heme Detoxification as Adjunctive Therapies for Cerebr
    LEONARDO JOSE DE MOURA CARVALHO; Fiscal Year: 2012
    ..In the murine model of CM by Plasmodium berghei ANKA (PbA), CM has been associated to low nitric oxide (NO) bioavailability, and treatment with exogenous NO prevented CM development...
  22. Arginine Availability and Metabolism in the Immune Evasion of H. pylori
    Keith T Wilson; Fiscal Year: 2013
    ..pylori. L-Arg is the common substrate for two divergent enzymatic pathways: inducible nitric oxide (NO) synthase (iNOS), that generates high output NO;and arginase, consisting of two forms, arginase I (Arg1) ..
  23. UV-induced and NOS-mediated Zn elevation, translation regulation and apoptosis
    Shiyong Wu; Fiscal Year: 2012
    ..The objective of this application is to elucidate the mechanisms that regulate UV-induced apoptosis via nitric oxide synthase (NOS) mediated signaling pathways and to determine the roles of nitric oxide (NO)/peroxynitrite (ONOO) ..
  24. Mechanism Underlying Nitrite Sensitivity of Mucoid Pseudomonas in COPD
    Daniel J Hassett; Fiscal Year: 2013
    ..Provision of mucA in trans restored A-NO2- resistance and subsequent experiments established that nitric oxide (NO) plays a role in cell death...
  25. Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
    THOMAS JAY EBERT; Fiscal Year: 2013
    ..In addition, the involvement of reactive oxygen species (ROS) and the nitric oxide pathway in the harmful effects of hyperglycemia and the beneficial effects of statins will be explored...
  26. Advanced Nitric Oxide Release Bactericidal Urinary Catheters
    Mark E Meyerhoff; Fiscal Year: 2013
    ..polymeric formulation to effectively reduce catheter-associated urinary tract infections (CAUTI) via nitric oxide (NO) release...
  27. Novel Means to Establish Free Radical Balance in the Neonatal Premature Lung
    Prakash Jagtap; Fiscal Year: 2011
    ..of RDS and BPD is consistent with a mechanism of injury produced by an excess of O2- and a deficiency of nitric oxide (NO) within the lung parenchyma...
  28. Interactions of the RAAS and a Western Diet on Insulin Metabolic Actions
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..in CV tissue leading to diminished INS metabolic signaling and biological consequences, such as impaired nitric oxide (NO)-mediated vascular relaxation...
  29. DNA Repair Deficiency Associated with Obesity and the Metabolic Syndrome
    R Stephen Lloyd; Fiscal Year: 2013
    ..of NEIL1 in the modulation of survival, mutagenesis, and mitochondrial function in response to oxidative or nitric oxide stress conditions...
  30. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2012
    ..vasculature, it is known that hypercholesterolemia induces endothelial dysfunction by negatively affecting nitric oxide synthases (NOS) and production of nitric oxide (NO), and NOS activity in blood vessels can be restored by ..
  31. FUNCTIONAL PROPERTIES OF HEMOGLOBINS AND MYOGLOBINS
    John S Olson; Fiscal Year: 2010
    ..determine the mechanism of how these proteins, microbial single domain globins, and flavohemoglobins oxidize nitric oxide to nitrate. Many of the specific aims associated with these goals have been achieved...
  32. Citrulline to Prevent or Mitigate Acute Lung Injury in Severe Sepsis
    Todd W Rice; Fiscal Year: 2013
    ..Inflammation results in plasma citrulline deficiency which leads to arginine deficiency and uncoupling of nitric oxide synthase (NOS)...
  33. Parvalbumin-Containing Neurons in Schizophrenia
    Tsung Ung W Woo; Fiscal Year: 2013
    ..that promote oxidative stress, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox) and neuronal nitric oxide synthase (nNOS), and the catalytic and modulatory subunits of the antioxidant enzyme glutamate cysteine ligase ..
  34. A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial Hypertension
    Steven Kawut; Fiscal Year: 2009
    ..Simvastatin decreases cholesterol, stabilizes the endothelial cell layer, increases the bioavailability of nitric oxide, reduces oxidative stress, and decreases inflammation...
  35. Tadalafil for Pulmonary Hypertension Associated with Chronic Lung Disease
    SHARON IRENE SMITH ROUNDS; Fiscal Year: 2013
    ..to maintain pulmonary vascular tone by degrading cGMP, which is a key signaling intermediary involved in nitric oxide (NO)-dependent signaling...
  36. Antenatal Betamethasone in Late Preterm Gestation Lambs
    SATYANARAYANA LAKSHMINRUSIMHA; Fiscal Year: 2010
    ..We will study the changes in important mediators of pulmonary transition at birth such as nitric oxide, beta adrenergic agents, natriuretic peptides and prostaglandins secondary to antenatal glucocorticoid use...
  37. Effects of GSH +/- Arginine on Markers of Inflammation Among Adults with CVD Risk
    Christopher D Gardner; Fiscal Year: 2010
    ..fasting insulin, serum isoprostanes (a measure of oxidative stress) and s-nitrosyl glutathione (a stable, nitric oxide containing compound)...
  38. Scavenging of Reactive Oxygen and Nitrogen Species by Cobalamins
    NICOLA ELIZABETH BRASCH; Fiscal Year: 2011
    ..oxidative and nitrosative stress" - elevated levels of Reactive Oxygen and Nitrogen Species (ROS/RNS), such as nitric oxide, superoxide, the hydroxyl radical, hydrogen peroxide and peroxynitrite...
  39. Respiration in Sepsis
    Claude A Piantadosi; Fiscal Year: 2013
    ..New preliminary data links AMPK activation to nitric oxide synthase-2 (NOS2) induction in sepsis, does not require high AMP/ATP, and loss of AMPK activation in nitric ..
  40. Role of Heme Oxygenase-1 in Sepsis
    Mark A Perrella; Fiscal Year: 2010
    ..has numerous biological functions, including anti- inflammatory properties, and shares many similarities with nitric oxide (NO), such as its ability to modulate vascular tone by increasing cGMP levels...
  41. Tumor Cell Arrest and Adhesion in the Microcirculation
    Bingmei M Fu; Fiscal Year: 2013
    ..mechanical factors, microvascular permeability (vascular integrity), cell adhesion molecules, nitric oxide and cytokines, and tumor metastasis in intact microvessels...
  42. Metabolic impact of fructose restriction in obese children
    Jean Marc Schwarz; Fiscal Year: 2013
    ..by stable isotope measurement), lipid partitioning within tissues (by magnetic resonance spectroscopy), and nitric oxide metabolites (by HLPC and ELISA) in children with metabolic syndrome, stratified by race and gender;and then ..
  43. Iron, NO, and Lipid Peroxide in Photodynamic Therapy
    ALBERT GIROTTI; Fiscal Year: 2013
    ..Studies supported by the existing grant have focused largely on the effects of nitric oxide (NO) in this regard...
  44. Molecular Mechanism of Acrolein-Induced Vascular Toxicity: Role of PPAR gamma and
    Zivar Yousefipour; Fiscal Year: 2013
    ..This process involves nitric oxide (NO) and oxygen free radicals...
  45. Role of endothelin receptors in glaucomatous optic neuropathy
    Raghu R Krishnamoorthy; Fiscal Year: 2013
    ..coupled receptors, namely, the ETA and ETB receptors, which are B predominantly linked to the calcium and nitric oxide signaling pathways respectively...
  46. Mechanisms of Vasovagal Syncope
    Julian M Stewart; Fiscal Year: 2013
    ..Preliminary data support the hypothesis that production of nitric oxide (NO) is enhanced in these patients resulting in reduced sympathetic noradrenergic neurotransmission at pre-..
  47. Novel Therapeutic Targets in Necrotizing Enterocolitis
    Peter J Giannone; Fiscal Year: 2012
    ..Exciting new mechanisms regarding the pathogenesis of NEC have recently become known and nitric oxide (NO) dysregulation appears to play a major role in the development of NEC...
  48. Nitric Oxide Signaling with Heme Proteins
    William R Montfort; Fiscal Year: 2012
    ..competitive renewal of grant HL62969, focusing on the biophysics of nitrosyl heme chemistry and its role in nitric oxide (NO) signaling...
  49. Nitric Oxide and gastric motility in female diabetics
    Pandu R Gangula; Fiscal Year: 2010
    ..Recent studies have implicated a role for dysregulation of neuronal nitric oxide synthase (nNOS) in myenteric neurons and we surmised that gender differences in nitrergic control of gastric ..
  50. ROLE OF SAMe IN LIVER FUNCTION AND INJURY
    SHELLY CHI LOO LU; Fiscal Year: 2012
    ..Our new data also show cross-talks between AMPK and nitric oxide synthase in modulating the proliferative effect of HGF. How SAMe regulates these pathways will be elucidated. 2...
  51. Mechanism of eNOS Uncoupling in the Renal Microvasculature
    YVES CLAUDE GORIN; Fiscal Year: 2013
    ..A major defense of endothelial cells against vascular injury is endothelial nitric oxide synthase (eNOS), which generates nitric oxide (NO) in the presence of optimal concentrations of the substrate L-..
  52. Nitric Oxide in Pulmonary Hypertension
    Serpil C Erzurum; Fiscal Year: 2013
    ..The PAH cells have impaired production of the vasodilator nitric oxide (NO) due to post- translational mechanisms that include phosphorylation/inhibition of endothelial NO synthase (..
  53. Electron Transfer in Iron and Copper Proteins
    Jay R Winkler; Fiscal Year: 2013
    ..Important members of this class of enzymes are the heme-thiolate mono- oxygenases such as cytochrome P450 and nitric oxide synthases (NOS)...
  54. Regulation of the Endothelial Citrulline-Nitric Oxide Cycle
    Duane C Eichler; Fiscal Year: 2010
    ..a unique perspective of endothelial health, showing that argininosuccinate synthase (AS) of the citrulline-nitric oxide cycle must be functional to sustain nitric oxide (NO) production and to maintain cell viability...
  55. Endothelium-Myocardium Interaction in Netrin-1 Induced Cardioprotection
    HUA LINDA CAI; Fiscal Year: 2013
    ..cardioprotection in vivo and whether the protection is mediated by a DCC-ERK1/2-deepdent activation of eNOS /nitric oxide (NO") in cardiac microvascular endothelial cells that should be immediately activated upon netrin-1 perfusion, ..
  56. Control of Drug Delivery to the CNS: Modulating P-glycoprotein Activity
    William A Banks; Fiscal Year: 2013
    ..blood-brain barrier, Brain, CNS, p-glycoprotein, innate immune system, cytokines, tumor necrosis factor-alpha, nitric oxide BRIEF STATEMENT OF RESEARCH OBJECTIVES (Do not use continuation sheets) A major problem in developing effective ..
  57. A new ultra-low field in-vivo EPR technology for biomedical applications
    Inseob Hahn; Fiscal Year: 2012
    ..provided by applicant): The most successful uses of in vivo EPR have been non-invasive measurement of oxygen, nitric oxide, bioradicals, pH and redox state, with applications in oncology, cardiology, neuroscience and toxicology...
  58. A new ultra-low field in-vivo EPR technology for biomedical applications
    Inseob Hahn; Fiscal Year: 2011
    ..provided by applicant): The most successful uses of in vivo EPR have been non-invasive measurement of oxygen, nitric oxide, bioradicals, pH and redox state, with applications in oncology, cardiology, neuroscience and toxicology...
  59. Transplantation of Reduced-Size Fatty Livers
    Zhi Zhong; Fiscal Year: 2010
    ..of antioxidants (Ad-superoxide dismutase, N-acetylcysteine and polyphenols) and antinitrative therapies (nitric oxide synthase inhibitors) on survival and injury of fatty partial grafts will be evaluated...
  60. Dietary Scavenging of Reactive Species in Lung Injury: Role of Macrophages
    THEA NOREEN GOLDEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Nitric oxide plays a central role in respiratory physiology including regulation of airway tone, vasodilation, inflammation and lung morphogenesis...
  61. Rheologic and Vascular Modulators in Sickle Vaso-occlusion
    Dhananjay K Kaul; Fiscal Year: 2012
    ..hypothesize that HIF-1[unreadable] expression will be dependent not only on tissue oxygen tension, but also on nitric oxide (NO) bioavailability, carbon monoxide (CO) generation and increased oxidative stress (reperfusion injury)...
  62. Balance of Angiotensin II/Angiotensin (1-1): A Target in Ischemic Stroke
    Yanfang Chen; Fiscal Year: 2013
    ..Reactive oxygen species (ROS) have been recognized as a major factor contributing to ischemic damage. Nitric oxide (NO) from endothelium nitric oxide synthase (eNOS) is important in maintaining normal cerebral blood flow...
  63. Nitric Oxide Releasing Topical Gel for Burn Wound Healing
    ANJAL SHARMA; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Nitric oxide (NO) gas has been shown to play a significant role in the promotion and regulation of diverse wound healing processes, including burn wounds...
  64. Nitric Oxide in Pulmonary Hypertension
    Serpil Erzurum; Fiscal Year: 2009
    ..The PAH cells have impaired production of the vasodilator nitric oxide (NO) due to post- translational mechanisms that include phosphorylation/inhibition of endothelial NO synthase (..
  65. NITRIC OXIDE INHIBITOR AND LEISHMANIA PATHOGENESIS
    MARION CHAN; Fiscal Year: 2004
    ..Current studies suggest that nitric oxide (NO) and peroxynitrite are crucial for elimination of the Leishmania parasites...
  66. Arginase and Regulation of Nitric Oxide Synthase in ALS
    Rajiv Ratan; Fiscal Year: 2004
    ..As nitric oxide (NO) has been shown to mediate neuronal loss in other neurodegenerative conditions, several groups have ..
  67. Renal Control of Blood Pressure in Early Diabetes
    Michael Brands; Fiscal Year: 2007
    ..in diabetes causes significant renal vasoconstriction and hypertension if it occurs under conditions of chronic nitric oxide (NO) synthesis inhibition...
  68. NITRIC OXIDE AND GASTROINTESTINAL OXIDATIVE INJURY
    Walee Chamulitrat; Fiscal Year: 1999
    ..Constitutive nitric oxide regulates GI motility, leukocyte adherance and mucosal permeability...
  69. SUBSTANCE P, NO & MICROGLIA IN CNS INFLAMMATION
    Barnett Nathan; Fiscal Year: 2003
    ..next 5 years I plan to study in vitro and in vivo the interactions of microglia, macrophages, substance P and nitric oxide as well as the effect of these substances on mitochondrial function...
  70. Targeting Inflammation to Improve Endothelial Function in Type 2 Diabetes: A Subs
    Mark A Creager; Fiscal Year: 2010
    ..including type 2 diabetes mellitus, are associated with decreased bioavailability of endothelium-derived nitric oxide (NO) and impaired endothelium-dependent vasodilation, and impaired endothelial function predicts cardiovascular ..