nitric oxide

Summary

Summary: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.

Top Publications

  1. ncbi Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways
    Walkyria Oliveira Sampaio
    Department of Physiology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Hypertension 49:185-92. 2007
  2. pmc Nitric oxide and peroxynitrite in health and disease
    Pal Pacher
    Section on Oxidative Stress Tissue Injury, Laboratory of Physiologic Studies, National Institutes of Health, National Institute of Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    Physiol Rev 87:315-424. 2007
  3. ncbi Nitric oxide and the immune response
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, Friedrich Alexander University of Erlangen Nuremberg, Wasserturmstrasse 3 5, D 91054 Erlangen, Germany
    Nat Immunol 2:907-16. 2001
  4. ncbi Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force
    Mary C Corretti
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland 21205 1595, USA
    J Am Coll Cardiol 39:257-65. 2002
  5. pmc Nitric oxide synthases: structure, function and inhibition
    W K Alderton
    In Vitro Pharmacology Department, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, UK
    Biochem J 357:593-615. 2001
  6. ncbi Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    S Dimmeler
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Nature 399:601-5. 1999
  7. ncbi Protein S-nitrosylation: purview and parameters
    Douglas T Hess
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Mol Cell Biol 6:150-66. 2005
  8. pmc Nitric oxide synthases: regulation and function
    Ulrich Förstermann
    Department of Pharmacology, Johannes Gutenberg University Medical Center, 55101 Mainz, Germany
    Eur Heart J 33:829-37, 837a-837d. 2012
  9. ncbi Endothelial nitric oxide synthase in vascular disease: from marvel to menace
    Ulrich Förstermann
    Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany
    Circulation 113:1708-14. 2006
  10. ncbi Role of endothelial dysfunction in atherosclerosis
    Jean Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Ave W, Montreal, QC H2W 1R7, Canada
    Circulation 109:III27-32. 2004

Detail Information

Publications325 found, 100 shown here

  1. ncbi Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways
    Walkyria Oliveira Sampaio
    Department of Physiology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Hypertension 49:185-92. 2007
    ..These novel data highlight the importance of the Ang-(1-7)/Mas axis as a putative regulator of endothelial function...
  2. pmc Nitric oxide and peroxynitrite in health and disease
    Pal Pacher
    Section on Oxidative Stress Tissue Injury, Laboratory of Physiologic Studies, National Institutes of Health, National Institute of Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    Physiol Rev 87:315-424. 2007
    The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide (NO) has stimulated an extraordinary impetus for scientific research in all the fields of biology and medicine...
  3. ncbi Nitric oxide and the immune response
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, Friedrich Alexander University of Erlangen Nuremberg, Wasserturmstrasse 3 5, D 91054 Erlangen, Germany
    Nat Immunol 2:907-16. 2001
    During the past two decades, nitric oxide (NO) has been recognized as one of the most versatile players in the immune system...
  4. ncbi Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force
    Mary C Corretti
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland 21205 1595, USA
    J Am Coll Cardiol 39:257-65. 2002
    ..The technique provokes the release of nitric oxide, resulting in vasodilation that can be quantitated as an index of vasomotor function...
  5. pmc Nitric oxide synthases: structure, function and inhibition
    W K Alderton
    In Vitro Pharmacology Department, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, UK
    Biochem J 357:593-615. 2001
    This review concentrates on advances in nitric oxide synthase (NOS) structure, function and inhibition made in the last seven years, during which time substantial advances have been made in our understanding of this enzyme family...
  6. ncbi Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    S Dimmeler
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Nature 399:601-5. 1999
    b>Nitric oxide (NO) produced by the endothelial NO synthase (eNOS) is a fundamental determinant of cardiovascular homesotasis: it regulates systemic blood pressure, vascular remodelling and angiogenesis...
  7. ncbi Protein S-nitrosylation: purview and parameters
    Douglas T Hess
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Mol Cell Biol 6:150-66. 2005
    ..S-nitrosylation thereby conveys a large part of the ubiquitous influence of nitric oxide (NO) on cellular signal transduction, and provides a mechanism for redox-based physiological regulation.
  8. pmc Nitric oxide synthases: regulation and function
    Ulrich Förstermann
    Department of Pharmacology, Johannes Gutenberg University Medical Center, 55101 Mainz, Germany
    Eur Heart J 33:829-37, 837a-837d. 2012
    b>Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of NO synthase (NOS; EC 1.14.13.39)...
  9. ncbi Endothelial nitric oxide synthase in vascular disease: from marvel to menace
    Ulrich Förstermann
    Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany
    Circulation 113:1708-14. 2006
    b>Nitric oxide (NO*) is an important protective molecule in the vasculature, and endothelial NO* synthase (eNOS) is responsible for most of the vascular NO* produced...
  10. ncbi Role of endothelial dysfunction in atherosclerosis
    Jean Davignon
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Ave W, Montreal, QC H2W 1R7, Canada
    Circulation 109:III27-32. 2004
    ..Many of these effects are largely mediated by nitric oxide, the most potent endogenous vasodilator...
  11. pmc Arginine metabolism: nitric oxide and beyond
    G Wu
    Departments of Animal Science, Medical Physiology, and Veterinary Anatomy and Public Health, and Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    Biochem J 336:1-17. 1998
    ..amino acids in animal cells, serving as a precursor for the synthesis not only of proteins but also of nitric oxide, urea, polyamines, proline, glutamate, creatine and agmatine...
  12. pmc Concepts of neural nitric oxide-mediated transmission
    John Garthwaite
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WCIE 6BT, UK
    Eur J Neurosci 27:2783-802. 2008
    As a chemical transmitter in the mammalian central nervous system, nitric oxide (NO) is still thought a bit of an oddity, yet this role extends back to the beginnings of the evolution of the nervous system, predating many of the more ..
  13. doi Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide
    Guangwen Ren
    Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 661 Hoes Lane, Piscataway, NJ 08854, USA
    Cell Stem Cell 2:141-50. 2008
    ..These cytokine combinations provoke the expression of high levels of several chemokines and inducible nitric oxide synthase (iNOS) by MSCs...
  14. doi On the origins of nitric oxide
    Kapuganti J Gupta
    Energy Metabolism Research Group, Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
    Trends Plant Sci 16:160-8. 2011
    b>Nitric oxide (NO) is widely recognized for its role as signaling compound...
  15. pmc Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani
    H W Murray
    Department of Medicine, Division of Hematology Oncology, Cornell University Medical College, New York 10021, USA
    J Exp Med 189:741-6. 1999
    ..respiratory burst-deficient gp91(phox)-/- (X-linked chronic granulomatous disease [X-CGD]) mice and inducible nitric oxide synthase (iNOS) knockout (KO) mice displayed comparably increased susceptibility...
  16. pmc Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
    D Fulton
    Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Nature 399:597-601. 1999
    Endothelial nitric oxide synthase (eNOS) is the nitric oxide synthase isoform responsible for maintaining systemic blood pressure, vascular remodelling and angiogenesis...
  17. doi Nitric oxide and oxidative stress in vascular disease
    Ulrich Förstermann
    Department of Pharmacology, Johannes Gutenberg University Medical Center, Obere Zahlbacher Strasse 67, 55101, Mainz, Germany
    Pflugers Arch 459:923-39. 2010
    Endothelium-derived nitric oxide (NO) is a paracrine factor that controls vascular tone, inhibits platelet function, prevents adhesion of leukocytes, and reduces proliferation of the intima...
  18. pmc cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action
    Sharron H Francis
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 2215 Garland Avenue, Nashville, TN 37232 0615, USA
    Pharmacol Rev 62:525-63. 2010
    To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by cyclic nucleotide phosphodiesterases (PDEs)...
  19. ncbi S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration
    Takashi Uehara
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 441:513-7. 2006
    ..manifesting sporadic Parkinson's or Alzheimer's disease, that PDI is S-nitrosylated, a reaction transferring a nitric oxide (NO) group to a critical cysteine thiol to affect protein function...
  20. ncbi Adiponectin stimulates production of nitric oxide in vascular endothelial cells
    Hui Chen
    Diabetes Unit, Laboratory of Clinical Investigation, NCCAM, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:45021-6. 2003
    ..The vascular action of insulin to stimulate endothelial production of nitric oxide (NO), leading to vasodilation and increased blood flow is an important component of insulin-stimulated whole ..
  21. pmc Biochemical and functional characterization of three activated macrophage populations
    Justin P Edwards
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    J Leukoc Biol 80:1298-307. 2006
    ..These are sphingosine kinase-1 and LIGHT (TNF superfamily 14). Thus, Ca-Mphi, Mphi-II, and AA-Mphi represent three populations of cells with different biological functions...
  22. doi Molecular hydrogen inhibits lipopolysaccharide/interferon γ-induced nitric oxide production through modulation of signal transduction in macrophages
    Tomohiro Itoh
    Department of Longevity and Aging Research, Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Biochem Biophys Res Commun 411:143-9. 2011
    ..In the present study, we examined the hydrogen effects on lipopolysaccharide/interferon γ LPS/IFNγ-induced nitric oxide (NO) production in murine macrophage RAW264 cells...
  23. doi Phylogenetic analysis of nitrite, nitric oxide, and nitrous oxide respiratory enzymes reveal a complex evolutionary history for denitrification
    Christopher M Jones
    Department of Microbiology, Swedish Agricultural University, Uppsala, Sweden
    Mol Biol Evol 25:1955-66. 2008
    Denitrification is a facultative respiratory pathway in which nitrite (NO2(-)), nitric oxide (NO), and nitrous oxide (N2O) are successively reduced to nitrogen gas (N(2)), effectively closing the nitrogen cycle...
  24. doi Nitric oxide signaling in brain function, dysfunction, and dementia
    Joern R Steinert
    Neurotoxicity at the Synaptic Interface, MRC Toxicology Unit, University of Leicester, Leicester, UK
    Neuroscientist 16:435-52. 2010
    b>Nitric oxide (NO) is an important signaling molecule that is widely used in the nervous system...
  25. doi β Common receptor integrates the erythropoietin signaling in activation of endothelial nitric oxide synthase
    Kuo Hui Su
    Department of Physiology, National Yang Ming University, Taipei, Taiwan
    J Cell Physiol 226:3330-9. 2011
    Erythropoietin (EPO), the key hormone for erythropoiesis, also increases nitric oxide (NO) bioavailability in endothelial cells (ECs), yet the definitive mechanisms are not fully understood...
  26. doi Nitric oxide signaling: classical, less classical, and nonclassical mechanisms
    Antonio Martínez-Ruiz
    Servicio de Inmunologia, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa IP, Madrid, Spain
    Free Radic Biol Med 51:17-29. 2011
    Although nitric oxide (NO) was identified more than 150 years ago and its effects were clinically tested in the form of nitroglycerine, it was not until the decades of 1970-1990 that it was described as a gaseous signal transducer...
  27. pmc Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes
    Veronika Lukacs-Kornek
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Nat Immunol 12:1096-104. 2011
    ..we report that FRCs and LECs inhibited T cell proliferation through a tightly regulated mechanism dependent on nitric oxide synthase 2 (NOS2)...
  28. doi Nitric oxide, stomatal closure, and abiotic stress
    Steven Neill
    Centre for Research in Plant Science, Faculty of Health and Life Sciences, University of the West of England, Bristol BS16 1QY, UK
    J Exp Bot 59:165-76. 2008
    Various data indicate that nitric oxide (NO) is an endogenous signal in plants that mediates responses to several stimuli...
  29. ncbi High glucose impairs early and late endothelial progenitor cells by modifying nitric oxide-related but not oxidative stress-mediated mechanisms
    Yung Hsiang Chen
    School of Medicine, National Yang Ming University, Taipei City, Taiwan
    Diabetes 56:1559-68. 2007
    ..Endothelial progenitor cells (EPCs) are impaired in diabetes. This study aimed to investigate the direct effects of high glucose on EPCs...
  30. ncbi Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity
    C Bogdan
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Erlangen, D 91054, Germany
    Curr Opin Immunol 12:64-76. 2000
    b>Nitric oxide, nitric oxide derivatives and reactive oxygen intermediates are toxic molecules of the immune system which contribute to the control of microbial pathogens and tumors...
  31. ncbi Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation
    Peter F Mount
    Department of Nephrology, Austin Health, Studley Road, Heidelberg 3084, Victoria, Australia
    J Mol Cell Cardiol 42:271-9. 2007
    The controlled regulation of nitric oxide (NO) synthesis in endothelial cells and cardiomyocytes by the endothelial form of nitric oxide synthase (eNOS or NOS3) is essential for cardiovascular health...
  32. ncbi Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB
    Maristela Lika Onozato
    Division of Nephrology and Endocrinology, University of Tokyo, Tokyo, Japan
    Kidney Int 61:186-94. 2002
    ..adenine dinucleotide phosphate [NAD(P)H] oxidase, whose product superoxide anion (O2-) can interact with nitric oxide (NO) to form peroxynitrite (ONOO-)...
  33. ncbi Nitric oxide and superoxide in inflammation and immune regulation
    T J Guzik
    Chair of Pharmacology, Jagiellonian University School of Medicine, Poland
    J Physiol Pharmacol 54:469-87. 2003
    b>Nitric oxide (NO) and reactive oxygen species exert multiple modulating effects on inflammation and play a key role in the regulation of immune responses. They affect virtually every step of the development of inflammation...
  34. doi Connecting the chemical and biological properties of nitric oxide
    José Carlos Toledo
    Departamento de Quimica, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
    Chem Res Toxicol 25:975-89. 2012
    b>Nitric oxide (NO(•); nitrogen monoxide) is known to be a critical regulator of cell and tissue function through mechanisms that utilize its unique physicochemical properties as a small and uncharged free radical with limited reactivity...
  35. pmc Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase
    Barbara Wegiel
    Transplant Institute, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 108:18849-54. 2011
    ..BV) quells the cellular response to endotoxin-induced inflammation through phosphorylation of endothelial nitric oxide synthase (eNOS)...
  36. doi Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital OX3 9DU, Oxford, UK
    Circulation 124:335-45. 2011
    ..We examined the direct effects of atorvastatin on tetrahydrobiopterin-mediated endothelial nitric oxide (NO) synthase coupling in patients with coronary artery disease.
  37. ncbi Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells
    Duk Hee Kang
    Division of Nephrology, Ewha Women s University Hospital, Seoul, Korea
    J Am Soc Nephrol 16:3553-62. 2005
    ..UA also increased HVSMC migration and inhibited HUVEC migration. In HUVEC, UA reduced nitric oxide (NO) release...
  38. ncbi S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding
    Makoto R Hara
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nat Cell Biol 7:665-74. 2005
    ..Here we report a signalling pathway in which nitric oxide (NO) generation that follows apoptotic stimulation elicits S-nitrosylation of GAPDH, which triggers binding to ..
  39. doi Intake of red wine increases the number and functional capacity of circulating endothelial progenitor cells by enhancing nitric oxide bioavailability
    Po Hsun Huang
    Division of Cardiology, Taipei Veterans General Hospital, Taipei, Taiwan
    Arterioscler Thromb Vasc Biol 30:869-77. 2010
    ..This study tested the hypothesis that intake of RW may promote the circulating endothelial progenitor cell (EPC) level and function through enhancement of nitric oxide bioavailability.
  40. ncbi High-yield isolation of murine microglia by mild trypsinization
    Josep Saura
    Department of Pharmacology and Toxicology, Institut d Investigacions Biomediques de Barcelona, IIBB CSIC, Barcelona, Spain
    Glia 44:183-9. 2003
    ..Because of its high yield, it can be especially convenient when high amounts of microglial protein/mRNA are required or in cases in which the starting material is limited, such as microglial cultures from transgenic animals...
  41. doi Methods of nitric oxide detection in plants: a commentary
    Luis A J Mur
    University of Wales, Aberystwyth, Institute of Biological Sciences, Aberystwyth, Wales, UK
    Plant Sci 181:509-19. 2011
    Over the last decade nitric oxide (NO) has been shown to influence a range of processes in plants. However, when, where and even if NO production occurs is controversial in several physiological scenarios in plants...
  42. ncbi Reactive oxygen species, antioxidant systems and nitric oxide in peroxisomes
    Luis A del Rio
    Departamento de Bioquimica, Biologia Celular y Molecular de Plantas, Estacion Experimental del Zaidin, CSIC, Apartado 419, E 18080 Granada, Spain
    J Exp Bot 53:1255-72. 2002
    ..for peroxisomes related to reactive oxygen species (ROS), but the recent demonstration of the presence of nitric oxide synthase (NOS) in plant peroxisomes implies that these organelles could also have a function in plant cells as ..
  43. ncbi The hamster as a model of human visceral leishmaniasis: progressive disease and impaired generation of nitric oxide in the face of a prominent Th1-like cytokine response
    P C Melby
    Medical Service, Department of Veterans Affairs Medical Center, South Texas Veterans Health Care System, San Antonio, TX 78284, USA
    J Immunol 166:1912-20. 2001
    ..Thus, although a Th1-like cytokine response was prominent, the major antileishmanial effector mechanism that is responsible for control of infection in mice was absent throughout the course of progressive VL in the hamster...
  44. pmc Plasma sodium stiffens vascular endothelium and reduces nitric oxide release
    Hans Oberleithner
    Institute of Physiology II and Department of Internal Medicine D, University of Munster, 48149 Munster, Germany
    Proc Natl Acad Sci U S A 104:16281-6. 2007
    ..b>Nitric oxide formation was found down-regulated in cells cultured in aldosterone-containing high sodium medium...
  45. ncbi Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase
    G C Brown
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK
    Biochim Biophys Acta 1504:46-57. 2001
    b>Nitric oxide (NO) and its derivatives inhibit mitochondrial respiration by a variety of means...
  46. ncbi Production of nitric oxide by glial cells: regulation and potential roles in the CNS
    S Murphy
    Department of Pharmacology and the Neuroscience Program, University of Iowa College of Medicine, Iowa City, USA
    Glia 29:1-13. 2000
    Roles proposed for nitric oxide (NO) in CNS pathophysiology are increasingly diverse and range from intercellular signaling, through necrotic killing of cells and invading pathogens, to the involvement of NO in apoptosis and tissue ..
  47. pmc Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats
    Jae Hyung Kim
    Anesthesiology, Tower 711, Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21287, USA
    J Appl Physiol (1985) 107:1249-57. 2009
    ..In this study, we demonstrate that arginase upregulation leads to endothelial nitric oxide synthase (eNOS) uncoupling and that in vivo chronic inhibition of arginase restores nitroso-redox balance, ..
  48. ncbi Endothelial function: a critical determinant in atherosclerosis?
    Ulf Landmesser
    Medizinische Hochschule Hannover, Abteilung Kardiologie und Angiologie, Carl Neuberg Str 1, 30625 Hannover, Germany
    Circulation 109:II27-33. 2004
    ..An important rationale for this approach has been the observation that endothelium-derived nitric oxide (NO), a major mediator of endothelium-dependent vasodilation, has important anti-inflammatory and ..
  49. pmc Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells
    Nikki Charles
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cell Stem Cell 6:141-52. 2010
    ..We investigated the potential role of nitric oxide (NO) activity in the perivascular niche (PVN) using a genetic engineered mouse model of PDGF-induced gliomas...
  50. ncbi Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
    Kenyatta Cosby
    Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 7B15 Bethesda, Maryland 20892, USA
    Nat Med 9:1498-505. 2003
    Nitrite anions comprise the largest vascular storage pool of nitric oxide (NO), provided that physiological mechanisms exist to reduce nitrite to NO...
  51. ncbi A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Toronto, Canada
    Circulation 106:913-9. 2002
    Given the central importance of nitric oxide (NO) in the development and clinical course of cardiovascular diseases, we sought to determine whether the powerful predictive value of C-reactive protein (CRP) might be explained through an ..
  52. ncbi Mechanisms underlying endothelial dysfunction in diabetes mellitus
    U Hink
    Universitatskrankenhaus Eppendorf, Germany
    Circ Res 88:E14-22. 2001
    ..endothelial cells in vitro with high concentrations of glucose activates protein kinase C (PKC) and increases nitric oxide synthase (NOS III) gene expression as well as superoxide production. The underlying mechanisms remain unknown...
  53. pmc The chemical biology of nitric oxide: implications in cellular signaling
    Douglas D Thomas
    Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Free Radic Biol Med 45:18-31. 2008
    b>Nitric oxide (NO) has earned the reputation of being a signaling mediator with many diverse and often opposing biological activities...
  54. pmc Amorphous silica nanoparticles trigger nitric oxide/peroxynitrite imbalance in human endothelial cells: inflammatory and cytotoxic effects
    J Jose Corbalan
    School of Pharmacy and Pharmaceutical Sciences, Faculty of Health Sciences, Panoz Institute, Trinity College Dublin, Dublin, Ireland
    Int J Nanomedicine 6:2821-35. 2011
    ..The purpose of this study was to investigate the mechanism of noxious effects of amorphous silica nanoparticles on human endothelial cells...
  55. doi Flow-mediated dilation and cardiovascular event prediction: does nitric oxide matter?
    Daniel J Green
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool L3 3AF, UK
    Hypertension 57:363-9. 2011
    ..been assumed that this association is related to the proposal that FMD provides an index of endothelium-derived nitric oxide (NO) function...
  56. ncbi Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
    D K Dalton
    Genentech Inc, South San Francisco, CA 94080
    Science 259:1739-42. 1993
    ..Resting splenic natural killer cell activity was reduced in IFN-gamma-deficient mice. Thus, IFN-gamma is essential for the function of several cell types of the murine immune system...
  57. pmc Cellular signaling and NO production
    Thomas Michel
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Pflugers Arch 459:807-16. 2010
    ..The best characterized endothelium-derived relaxing factor is nitric oxide (NO), which is synthesized by the endothelial isoform of nitric oxide synthase (eNOS)...
  58. pmc Arginase: a critical regulator of nitric oxide synthesis and vascular function
    William Durante
    Department of Medical Pharmacology and Physiology, University of Missouri Columbia, Columbia, Missouri 65212, USA
    Clin Exp Pharmacol Physiol 34:906-11. 2007
    ..studies have identified arginase in the vasculature and have implicated this enzyme in the regulation of nitric oxide (NO) synthesis and the development of vascular disease. 2...
  59. ncbi Aged garlic extract enhances production of nitric oxide
    Naoaki Morihara
    Healthcare Research Institute, Wakunaga Pharmaceutical Co Ltd, 1624 Shimokotachi, Kodacho Takatagun, 739 1195, Hiroshima, Japan
    Life Sci 71:509-17. 2002
    b>Nitric oxide (NO) controls several physiological functions of the cardiovascular system...
  60. pmc Effect of exercise training on endothelium-derived nitric oxide function in humans
    Daniel J Green
    School of Human Movement and Exercise Science, University of Western Australia, Mailbag Delivery M408, 35 Stirling Highway, Crawley WA 6009, Australia
    J Physiol 561:1-25. 2004
    ..These functions are due to the production of numerous autacoids, of which nitric oxide (NO) has been the most widely studied...
  61. pmc Complex inhibitory effects of nitric oxide on autophagy
    Sovan Sarkar
    Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0XY, UK
    Mol Cell 43:19-32. 2011
    ..Several autophagy regulators have been identified in recent years. Here we show that nitric oxide (NO), a potent cellular messenger, inhibits autophagosome synthesis via a number of mechanisms...
  62. ncbi Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A
    Anthony R Smith
    Linus Pauling Institute and Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA
    Aging Cell 5:391-400. 2006
    ..that post-translational signaling pathways become disrupted with age and adversely affect endothelial nitric oxide synthase (eNOS) activity and endothelial-derived nitric oxide (NO) production...
  63. pmc Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation
    N A Riobo
    Laboratory of Oxygen Metabolism, University Hospital, University of Buenos Aires, Cordoba 2351, 1120, Buenos Aires, Argentina
    Biochem J 359:139-45. 2001
    ..Inhibition of Complex I activity by peroxynitrite may have critical implications for energy supply in tissues such as the brain, whose mitochondrial function depends largely on the channelling of reducing equivalents through Complex I...
  64. doi Nitric oxide and neuronal death
    Guy C Brown
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, United Kingdom
    Nitric Oxide 23:153-65. 2010
    ..iNOS is induced in glia by inflammation, and may protect; however, if there is also hypoxia or the NADPH oxidase is active, it can induce neuronal death. Microglial phagocytosis may contribute actively to neuronal loss...
  65. pmc Redox regulation of the NPR1-TGA1 system of Arabidopsis thaliana by nitric oxide
    Christian Lindermayr
    Institute of Biochemical Plant Pathology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, D 85764 Neuherberg, Germany
    Plant Cell 22:2894-907. 2010
    ..Here, we report the effect of the physiological nitric oxide donor S-nitrosoglutathione on the NPR1/TGA1 regulation system in Arabidopsis thaliana...
  66. pmc Candidate pathways linking inducible nitric oxide synthase to a basal-like transcription pattern and tumor progression in human breast cancer
    Stefan Ambs
    Laboratory of Human Carcinogenesis, Center for Cancer Research CCR, National Cancer Institute NCI Bethesda, MD USA
    Cell Cycle 10:619-24. 2011
    Inducible nitric oxide synthase (NOS2) is an inflammation responsive enzyme (EC 1.14.13.39) that is induced during acute and chronic inflammation and tissue injury as part of the host defense and wound healing process...
  67. doi Mitochondrial generation of free radicals and hypoxic signaling
    Robert O Poyton
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Trends Endocrinol Metab 20:332-40. 2009
    ..Recently, it has become clear that under hypoxic conditions, the mitochondrial respiratory chain also produces nitric oxide (NO), which can generate other reactive nitrogen species (RNS)...
  68. pmc Protein S-nitrosylation in health and disease: a current perspective
    Matthew W Foster
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Trends Mol Med 15:391-404. 2009
    Protein S-nitrosylation constitutes a large part of the ubiquitous influence of nitric oxide on cellular signal transduction and accumulating evidence indicates important roles for S-nitrosylation both in normal physiology and in a broad ..
  69. ncbi Nitric oxide deficiency in chronic kidney disease
    Chris Baylis
    Division of Nephrology, Hypertension, and Transplantation, Department of Physiology, University of Florida College of Medicine, Gainesville, FL 32667, USA
    Am J Physiol Renal Physiol 294:F1-9. 2008
    The overall production of nitric oxide (NO) is decreased in chronic kidney disease (CKD) which contributes to cardiovascular events and further progression of kidney damage...
  70. ncbi Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
    Enzo Nisoli
    Integrated Laboratories Network, Department of Preclinical Sciences, Luigi Sacco Hospital, Milan University, 20157 Milan, Italy
    Science 310:314-7. 2005
    ..Here, we report that calorie restriction for either 3 or 12 months induced endothelial nitric oxide synthase (eNOS) expression and 3',5'-cyclic guanosine monophosphate formation in various tissues of male mice...
  71. pmc NMDA receptors in hippocampal GABAergic synapses and their role in nitric oxide signaling
    Eszter Szabadits
    Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, H 1083, Budapest, Hungary
    J Neurosci 31:5893-904. 2011
    ..Here, we provide evidence that the retrograde nitric oxide (NO)-cGMP cascade triggered by NMDA receptor (NMDAR) activation plays a role in the control of hippocampal ..
  72. ncbi Toward a biochemical understanding of human intervertebral disc degeneration and herniation. Contributions of nitric oxide, interleukins, prostaglandin E2, and matrix metalloproteinases
    J D Kang
    Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pennsylvania, USA
    Spine (Phila Pa 1976) 22:1065-73. 1997
    ..intervertebral disc specimens were cultured to study the effects of interleukin-1 beta on the production of nitric oxide, interleukin-6, prostaglandin E2, and matrix metalloproteinases...
  73. pmc Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and -scavenging systems
    Martin Feelisch
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 283:33927-34. 2008
    Although nitrite (NO(2)(-)) and nitrate (NO(3)(-)) have been considered traditionally inert byproducts of nitric oxide (NO) metabolism, recent studies indicate that NO(2)(-) represents an important source of NO for processes ranging from ..
  74. pmc Exhaled nitric oxide measurements: clinical application and interpretation
    D R Taylor
    Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, P O Box 913, Dunedin, New Zealand
    Thorax 61:817-27. 2006
    The use of exhaled nitric oxide measurements (F(E)NO) in clinical practice is now coming of age. There are a number of theoretical and practical factors which have brought this about...
  75. pmc Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1beta, TNF-alpha and IL-6 in an in-vitro model of brain inflammation
    Henrik Wilms
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Neuroinflammation 7:30. 2010
    ..The purpose of this study was to use an established in vitro model of brain inflammation to determine if DMF modulates the release of neurotoxic molecules from microglia and astrocytes, thus inhibiting glial inflammation...
  76. ncbi Nitric oxide as a secretory product of mammalian cells
    C Nathan
    Beatrice and Samuel A Seaver Laboratory, Cornell University Medical College, New York, New York 10021
    FASEB J 6:3051-64. 1992
    Evolution has resorted to nitric oxide (NO), a tiny, reactive radical gas, to mediate both servoregulatory and cytotoxic functions...
  77. ncbi Macrophage killing of Leishmania amazonensis amastigotes requires both nitric oxide and superoxide
    Rami M Mukbel
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA
    Am J Trop Med Hyg 76:669-75. 2007
    ..Herein we report that the presence of both superoxide and nitric oxide is necessary for efficient killing of L...
  78. pmc Nitric oxide, oxidants, and protein tyrosine nitration
    Rafael Radi
    Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, Avda General Flores 2125, 11800 Montevideo, Uruguay
    Proc Natl Acad Sci U S A 101:4003-8. 2004
    ....
  79. ncbi The role of nitric oxide in tumour progression
    Dai Fukumura
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Rev Cancer 6:521-34. 2006
    b>Nitric oxide (NO) and nitric oxide synthases are ubiquitous in malignant tumours and are known to exert both pro- and anti-tumour effects...
  80. pmc Direct impairment of vascular function by diesel exhaust particulate through reduced bioavailability of endothelium-derived nitric oxide induced by superoxide free radicals
    Mark R Miller
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    Environ Health Perspect 117:611-6. 2009
    ..Diesel exhaust particulate (DEP) is a key arbiter of the adverse cardiovascular effects of air pollution...
  81. ncbi Antidepressants inhibit interferon-gamma-induced microglial production of IL-6 and nitric oxide
    Sadayuki Hashioka
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, 812 8582 Japan
    Exp Neurol 206:33-42. 2007
    ..IFN-gamma)-induced microglial production of the pro-inflammatory mediators interleukin-6 (IL-6) and nitric oxide (NO)...
  82. pmc S-nitrosylation in cardiovascular signaling
    Brian Lima
    Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Circ Res 106:633-46. 2010
    ..2 decades have passed since the endothelium-derived relaxation factor was reported to be the gaseous molecule nitric oxide (NO)...
  83. ncbi Hypoxia-induced iNOS expression in microglia is regulated by the PI3-kinase/Akt/mTOR signaling pathway and activation of hypoxia inducible factor-1alpha
    Dah Yuu Lu
    Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
    Biochem Pharmacol 72:992-1000. 2006
    ..In this study, we demonstrated that hypoxia induced iNOS expression by regulation of HIF-1alpha in microglia...
  84. ncbi Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: important role of nitric oxide
    J Hoffmann
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Circ Res 89:709-15. 2001
    ..Thus, aging of endothelial cells is associated with decreased NO synthesis and concomitantly increased sensitivity of apoptosis, which may contribute to functional impairment of the endothelial monolayer...
  85. ncbi Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation
    Feng Gao
    Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Circulation 105:1497-502. 2002
    Recent evidence from cultured endothelial cell studies suggests that phosphorylation of endothelial nitric oxide synthase (eNOS) through the PI3-kinase-Akt pathway increases NO production...
  86. ncbi Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia
    Ki Kyung Jung
    Pharmacology Department, National Institute of Toxicological Research, KFDA, Seoul 122 704, Republic of Korea
    Life Sci 79:2022-31. 2006
    ..7 microM. It also suppressed both mRNA and protein levels of inducible nitric oxide synthase (iNOS), indicating that this drug may affect iNOS gene expression process...
  87. pmc Regulation of HIF-1alpha stability through S-nitrosylation
    Fang Li
    Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Mol Cell 26:63-74. 2007
    ..This interaction between NO and HIF-1 sheds new light on their involvement in tumor response to treatment as well as mammalian inflammation process in general...
  88. ncbi Race-specific differences in endothelial function: predisposition of African Americans to vascular diseases
    Leszek Kalinowski
    Department of Biochemistry, Ohio University, Athens, OH 45701, USA
    Circulation 109:2511-7. 2004
    ..Evidence has accumulated that superoxide (O2-) production and its interaction with nitric oxide (NO), yielding the strong oxidant peroxynitrite (ONOO-), play central roles in vascular pathophysiology...
  89. pmc Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice
    Masanori Ozaki
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 110:331-40. 2002
    b>Nitric oxide (NO) derived from endothelial NO synthase (eNOS) is regarded as a protective factor against atherosclerosis...
  90. pmc Nitric oxide and bone
    R J van't Hof
    Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, UK
    Immunology 103:255-61. 2001
    b>Nitric oxide (NO) is a free radical which has important effects on bone cell function...
  91. ncbi Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity
    A Bal-Price
    Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, United Kingdom
    J Neurosci 21:6480-91. 2001
    ..glia caused 75-100% necrotic cell death within 48 hr, which was completely prevented by inhibitors of inducible nitric oxide synthase (iNOS) (aminoguanidine or 1400W)...
  92. ncbi IL-10 mediates susceptibility to Leishmania donovani infection
    M L Murphy
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Eur J Immunol 31:2848-56. 2001
    ..Enhanced resistance was accompanied by increased production of IFN-gamma and nitric oxide in BALB/c IL-10-/- mice...
  93. ncbi Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis
    Uta Keil
    Department of Pharmacology, Biocenter, University of Frankfurt, 60439 Frankfurt, Germany
    J Biol Chem 279:50310-20. 2004
    ..acute and chronic exposure to increasing concentrations of amyloid beta (Abeta) on mitochondrial function and nitric oxide (NO) production in vitro and in vivo...
  94. pmc Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria
    Tsin W Yeo
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin NT 0810, Australia
    J Exp Med 204:2693-704. 2007
    ..Clinical trials in SM of adjunctive agents to improve endothelial NO bioavailability, including l-arginine, are warranted...
  95. pmc Interferon gamma activated macrophages kill mycobacteria by nitric oxide induced apoptosis
    Susanne Herbst
    Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    PLoS ONE 6:e19105. 2011
    ..the phagosome maturation block, nutrient deprivation and exposure to microbicidal effectors including nitric oxide (NO)...
  96. pmc Mycobacterium tuberculosis WhiB3 responds to O2 and nitric oxide via its [4Fe-4S] cluster and is essential for nutrient starvation survival
    Amit Singh
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 104:11562-7. 2007
    ..tuberculosis (Mtb) is to understand the mechanisms involved in sensing redox signals such as oxygen (O2), nitric oxide (NO), and nutrient depletion, which are thought to play a crucial role in persistence...
  97. doi Nitrate-nitrite-nitric oxide pathway: implications for anesthesiology and intensive care
    Eddie Weitzberg
    Section of Anesthesiology and Intensive Care, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Anesthesiology 113:1460-75. 2010
    The gaseous radical nitric oxide is involved in numerous physiologic and pathophysiological events important in anesthesiology and intensive care...
  98. ncbi Nitric oxide in health and disease of the respiratory system
    Fabio L M Ricciardolo
    Dept of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Physiol Rev 84:731-65. 2004
    During the past decade a plethora of studies have unravelled the multiple roles of nitric oxide (NO) in airway physiology and pathophysiology...
  99. pmc Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor
    Kenji Matsushita
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 115:139-50. 2003
    b>Nitric oxide (NO) inhibits vascular inflammation, but the molecular basis for its anti-inflammatory properties is unknown...
  100. ncbi Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria
    Guy C Brown
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK
    Mol Neurobiol 27:325-55. 2003
    ..glia become "activated" by inflammatory mediators, and express new proteins such as the inducible isoform of nitric oxide synthase (iNOS)...
  101. doi Was nitric oxide the first deep electron sink?
    Anne Lise Ducluzeau
    Laboratoire de Bioenergetique et Ingenierie des Proteines, Centre National de la Recherche Scientifique UPR9036, IFR77, Marseille Cedex 20, France
    Trends Biochem Sci 34:9-15. 2009
    ..Based on recent phylogenetic, enzymatic and geochemical results, we propose that, in the earliest Archaean, nitric oxide (NO) and its derivatives nitrate and nitrite served as strongly oxidizing substrates driving the evolution of a ..

Research Grants80

  1. Arginase and Regulation of Nitric Oxide Synthase in ALS
    Rajiv Ratan; Fiscal Year: 2004
    ..As nitric oxide (NO) has been shown to mediate neuronal loss in other neurodegenerative conditions, several groups have ..
  2. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    Christopher S Wilcox; Fiscal Year: 2010
    ..It is accompanied by increased reactive oxygen species (ROS) which can inactivate nitric oxide (NO). However, there is also an increase in asymmetric dimethylarginine (ADMA) which can inhibit NOS...
  3. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    Frances Walker; Fiscal Year: 2009
    ..The NPs are novel ferriheme proteins that are reversible carriers of nitric oxide (NO) and tight binders of histamine...
  4. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    Frances Walker; Fiscal Year: 2009
    ..The NPs are novel ferriheme proteins that are reversible carriers of nitric oxide (NO) and tight binders of histamine...
  5. Genetic Basis for Impaired Angiogenic Signaling in BPD
    STEVEN HERBERT ABMAN; Fiscal Year: 2010
    ..VEGF stimulates angiogenesis through upregulation of endothelial nitric oxide synthase (eNOS), which increases nitric oxide (NO) production...
  6. MANIPULATION OF PHAGOCYTOSIS IN MACROPHAGES
    Joel Swanson; Fiscal Year: 2003
    ..biochemical and fluorescence microscopic methods will be used to measure intravacuolar pH and intracellular nitric oxide levels. Sites of peroxynitrite generation will be localized in the cytopolasm and in individual phagosomes...
  7. HOMOCYST(E)INE, OXIDATIVE STRESS, AND NITRIC OXIDE
    Joseph Loscalzo; Fiscal Year: 2000
    ..microenvironment that leads to a state of endothelial dysfunction manifest by reduced production of bioactive nitric oxide. This effect is achieved by the formation of reactive oxygen species that react with and inactive nitric oxide, ..
  8. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    Frances Walker; Fiscal Year: 2006
    ..These heme proteins are novel Fe(lll) proteins that are reversible carriers of nitric oxide (NO) and tight binders of histamine...
  9. Nitric Oxide Releasing Topical Gel for Burn Wound Healing
    ANJAL SHARMA; Fiscal Year: 2007
    b>Nitric oxide (NO) gas has been shown to play a significant role in the promotion and regulation of diverse wound healing processes, including burn wounds...
  10. Role of iNOS, Nitric Oxide & Arginase in Statin-Mediated Toxicity in Cancer Cells
    Balaraman Kalyanaraman; Fiscal Year: 2009
    ..statins cause increased cytotoxicity to breast cancer cells through either increased expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) and/or decreased arginase expression...
  11. Nitric Oxide in Pulmonary Hypertension
    Serpil Erzurum; Fiscal Year: 2009
    ..The PAH cells have impaired production of the vasodilator nitric oxide (NO) due to post- translational mechanisms that include phosphorylation/inhibition of endothelial NO synthase (..
  12. VASCULAR ENDOTHELIUM ABNORMALITIES IN HEART FAILURE
    Stuart Katz; Fiscal Year: 1999
    ..Endothelial cell dysfunction appears to be characterized by decreased agonist-induced, endothelium-dependent, nitric oxide-mediated vasodilation and possibly increased release of the endothelium-derived vasoconstricting substance, ..
  13. Heme/Copper and Heme/Nonheme Iron O(2) and NO Reactivity
    Kenneth D Karlin; Fiscal Year: 2010
    ..ligation, spectroscopy and reactivity relevant to the chemistry utilized by heme-copper oxidases (HCOs) and nitric oxide reductases (NORs)...
  14. Heme/Copper and Heme/Nonheme Iron O(2) and NO Reactivity
    KENNETH KARLIN; Fiscal Year: 2009
    ..ligation, spectroscopy and reactivity relevant to the chemistry utilized by heme-copper oxidases (HCOs) and nitric oxide reductases (NORs)...
  15. NITRIC OXIDE INHIBITOR AND LEISHMANIA PATHOGENESIS
    MARION CHAN; Fiscal Year: 2004
    ..Current studies suggest that nitric oxide (NO) and peroxynitrite are crucial for elimination of the Leishmania parasites...
  16. TETRAHYDROBIOPTERIN--REGULATOR OF ENDOTHELIAL FUNCTION
    ZVONIMIR KATUSIC; Fiscal Year: 1999
    L-Arginine/nitric oxide pathway plays a key role in regulation of arterial tone. Biosynthesis of nitric oxide requires activation of nitric oxide synthase in the presence of tetrahydrobiopterin as a cofactor...
  17. Renal Control of Blood Pressure in Early Diabetes
    Michael Brands; Fiscal Year: 2007
    ..in diabetes causes significant renal vasoconstriction and hypertension if it occurs under conditions of chronic nitric oxide (NO) synthesis inhibition...
  18. SUBSTANCE P, NO & MICROGLIA IN CNS INFLAMMATION
    Barnett Nathan; Fiscal Year: 2003
    ..next 5 years I plan to study in vitro and in vivo the interactions of microglia, macrophages, substance P and nitric oxide as well as the effect of these substances on mitochondrial function...
  19. Targeting Inflammation to Improve Endothelial Function in Type 2 Diabetes: A Subs
    Mark A Creager; Fiscal Year: 2010
    ..including type 2 diabetes mellitus, are associated with decreased bioavailability of endothelium-derived nitric oxide (NO) and impaired endothelium-dependent vasodilation, and impaired endothelial function predicts cardiovascular ..
  20. Regulation of Endothelial Nitric Oxide Synthase mRNA stability
    Jianxin Sun; Fiscal Year: 2010
    b>Nitric oxide (NO), produced by endothelial nitric oxide synthase (eNOS), is critical to the maintenance of vascular homeostasis through promoting vasodilation and inhibiting vascular smooth muscle cells proliferation, platelets ..
  21. Inducible Nitric Oxide Synthase and Insulin Resistance
    Masao Kaneki; Fiscal Year: 2004
    ..resistance, including obesity and type 2 diabetes, are associated with increased expression of inducible nitric oxide synthase (iNOS) and oxidative stress...
  22. MEDIATORS OF PULMONARY VASODILATATION IN LIVER DISEASE
    Michael Fallon; Fiscal Year: 2003
    ..of chronic liver disease and is characterized by changes in the levels and activity of endothelial nitric oxide synthase...
  23. Role of iNOS, Nitric Oxide & Arginase in Statin-Mediated Toxicity in Cancer Cells
    Balaraman Kalyanaraman; Fiscal Year: 2010
    ..statins cause increased cytotoxicity to breast cancer cells through either increased expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) and/or decreased arginase expression...