- Free radicals in the physiological control of cell function
Division of Immunochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Physiol Rev 82:47-95. 2002
At high concentrations, free radicals and radical-derived, nonradical reactive species are hazardous for living organisms and damage all major cellular constituents...
- Free radicals, metals and antioxidants in oxidative stress-induced cancer
Faculty of Chemical and Food Technology, Slovak Technical University, SK 812 37 Bratislava, Slovakia
Chem Biol Interact 160:1-40. 2006
Oxygen-free radicals, more generally known as reactive oxygen species (ROS) along with reactive nitrogen species (RNS) are well recognised for playing a dual role as both deleterious and beneficial species...
- Taking a "good" look at free radicals in the aging process
Department of Biology, McGill University, Montreal, Canada H3A 1B1
Trends Cell Biol 21:569-76. 2011
..This could generate the observed correlation between aging and ROS without implying that ROS damage is the earliest trigger or main cause of aging...
- Free radicals and antioxidants - quo vadis?
Department of Biochemistry, National University of Singapore, 8 Medical Drive, Singapore 117597
Trends Pharmacol Sci 32:125-30. 2011
The field of free radicals and antioxidants, or 'redox biology', is fundamental to aerobic life. Aerobes constantly make reactive species, but modulate their actions by synthesizing antioxidants...
- Free radicals and antioxidants: updating a personal view
Department of Biochemistry, National University of Singapore, Singapore
Nutr Rev 70:257-65. 2012
..Increasing endogenous antioxidant levels (e.g., by supplying "pro-oxidants") may be a better approach to therapeutics and disease prevention than consuming large doses of "dietary antioxidants."..
- Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment
Department of Biochemistry, Faculty of Medicine, National University of Singapore, Singapore
Drugs Aging 18:685-716. 2001
b>Free radicals and other so-called 'reactive species' are constantly produced in the brain in vivo...
- Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules
Benjamin J Moeller
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
Cancer Cell 5:429-41. 2004
..These data describe novel pathways contributing significantly to our understanding of HIF-1 regulation which may be major determinants of tumor radiosensitivity, potentially having high clinical relevance...
- Free radicals and antioxidants in human health: current status and future prospects
T P A Devasagayam
Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400 085
J Assoc Physicians India 52:794-804. 2004
b>Free radicals and related species have attracted a great deal of attention in recent years...
- Free radicals, antioxidants, and nutrition
Yun Zhong Fang
Department of Biochemistry and Molecular Biology, Beijing Institute of Radiation Medicine, Beijing, China
Nutrition 18:872-9. 2002
..b>Free radicals (e.g., superoxide, nitric oxide, and hydroxyl radicals) and other reactive species (e.g...
- Architecture of the photosynthetic oxygen-evolving center
Kristina N Ferreira
Department of Biological Sciences, Imperial College London, London, SW7 2AZ, UK
Science 303:1831-8. 2004
..The details of the surrounding coordination sphere of the metal cluster and the implications for a possible oxygen-evolving mechanism are discussed...
- Production, detection, and adaptive responses to free radicals in exercise
Ethel Percy Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089 0191, USA
Free Radic Biol Med 44:215-23. 2008
b>Free radicals (particularly oxygen- and nitrogen-centered radicals), and related reactive oxygen and nitrogen species, are generated in cells and tissues during exercise...
- Free radical-mediated oxidation of free amino acids and amino acid residues in proteins
E R Stadtman
Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 8012, USA
Amino Acids 25:207-18. 2003
- Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
Mark W Dewhirst
Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
Nat Rev Cancer 8:425-37. 2008
Hypoxia and free radicals, such as reactive oxygen and nitrogen species, can alter the function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1)...
- Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention
Department of Pharmaceutical and Administrative Sciences, Creighton University School of Pharmacy and Allied Health Professions, 2500 California Plaza, Omaha, NE 68178, USA
Toxicology 148:187-97. 2000
b>Free radicals have been implicated in over a hundred disease conditions in humans, including arthritis, hemorrhagic shock, atherosclerosis, advancing age, ischemia and reperfusion injury of many organs, Alzheimer and Parkinson's disease, ..
- Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation
Andrey Y Abramov
Department of Physiology, University College London, London WC1E 6BT, United Kingdom
J Neurosci 27:1129-38. 2007
..Inhibition of either the NADPH oxidase or XO was significantly neuroprotective. Thus, oxidative stress contributes to cell death over and above the injury attributable to energy deprivation...
- Free radicals and aging
Department of Animal Physiology II, Faculty of Biology, Complutense University, Madrid 28040, Spain
Trends Neurosci 27:595-600. 2004
..Furthermore, caloric restriction, which decreases the rate of aging, proportionately decreases mitochondrial oxygen radical generation, especially at complex I. These findings are reviewed, highlighting the results obtained in the brain...
- Free radicals and muscle fatigue: Of ROS, canaries, and the IOC
Michael B Reid
Department of Physiology, University of Kentucky, Lexington, KY 40536 0298, USA
Free Radic Biol Med 44:169-79. 2008
- Free radicals and redox signalling in T-cells during chronic inflammation and ageing
Helen R Griffiths
School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK
Biochem Soc Trans 39:1273-8. 2011
..Together, these data suggest that a complex relationship exists between intra- and extra-cellular redox compartments which contribute to the T-cell phenotype...
- The oxygen free radicals originating from mitochondrial complex I contribute to oxidative brain injury following hypoxia-ischemia in neonatal mice
Zoya V Niatsetskaya
Department of Pediatrics, Columbia University, New York, New York 10032, USA
J Neurosci 32:3235-44. 2012
..This highlights a novel neuroprotective strategy against HI brain injury where the major therapeutic principle is a pharmacological attenuation, rather than an enhancement of mitochondrial oxidative metabolism during early reperfusion...
- Cardioprotection: a radical view Free radicals in pre and postconditioning
Dipartimento di Scienze Cliniche e Biologiche Università di Torino, Italy Istituto Nazionale Ricerche Cardiovascolari, Bologna, Italy
Biochim Biophys Acta 1787:781-93. 2009
..Therefore, our and others' results suggest that the role of ROS in reperfusion may be reconsidered as they are not only deleterious...
- Free radical-induced damage to DNA: mechanisms and measurement
Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899 8311, USA
Free Radic Biol Med 32:1102-15. 2002
b>Free radicals are produced in cells by cellular metabolism and by exogenous agents. These species react with biomolecules in cells, including DNA...
- Atmospheric-pressure plasma jet induces apoptosis involving mitochondria via generation of free radicals
Hak Jun Ahn
Department of Molecular Science and Technology and Department of Life Science, Ajou University, Suwon, Gyounggi do, Korea
PLoS ONE 6:e28154. 2011
..Taken together, our data suggest the potential employment of plasma jets as a novel therapy for cancer...
- The role of oxidants and free radicals in reperfusion injury
Jay L Zweier
Davis Heart and Lung Research Institute and the Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University College of Medicine, 473 W 12th Ave, Columbus, OH 43210, USA
Cardiovasc Res 70:181-90. 2006
..Ischemic preconditioning markedly decreases NO and oxidant generation, and this appears to be an important mechanism contributing to preconditioning-induced myocardial protection...
- NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease
Laboratory of Hepatobiology and Toxicology, Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599 7365, USA
J Clin Invest 106:867-72. 2000
..are known to contribute to early alcohol-induced liver injury via oxidative stress, the exact source of free radicals has remained a mystery...
- The Radical SAM Superfamily
Perry A Frey
Department of Biochemistry, University of Madison, Wisconin Madison, Wisconsin 53726, USA
Crit Rev Biochem Mol Biol 43:63-88. 2008
- Free radicals, mitochondria, and hypoxia-ischemia in the developing brain
Arvid Carlsson Institute, Sahlgrenska Academy, Goteborg University, Sweden
Free Radic Biol Med 40:388-97. 2006
..of its poorly developed scavenging systems and high availability of iron for the catalytic formation of free radicals. Neurons are more vulnerable to free radical damage than glial cells, but oligodendrocyte progenitors and ..
- Tobacco smoke: involvement of reactive oxygen species and stable free radicals in mechanisms of oxidative damage, carcinogenesis and synergistic effects with other respirable particles
Department of Chemistry, Free Radical Research Group, University of Athens, University Campus Zografou, 15784 Athens, Greece
Int J Environ Res Public Health 6:445-62. 2009
Tobacco smoke contains many toxic, carcinogenic and mutagenic chemicals, as well as stable and unstable free radicals and reactive oxygen species (ROS) in the particulate and the gas phase with the potential for biological oxidative ..
- The role of free radicals in the pathophysiology of muscular dystrophy
James G Tidball
Department of Physiological Science, University of California, Los Angeles, California 90095, USA
J Appl Physiol (1985) 102:1677-86. 2007
..likelihood that interactions between the primary genetic defect and disruptions in the normal production of free radicals contribute to the pathophysiology of muscular dystrophies...
- Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
M A Smith
Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
Proc Natl Acad Sci U S A 94:9866-8. 1997
Damage from free radicals has been demonstrated in susceptible neuronal populations in cases of Alzheimer disease...
- Theories of biological aging: genes, proteins, and free radicals
Suresh I S Rattan
Laboratory of Cellular Ageing, Department of Molecular Biology, Danish Centre for Molecular Gerontology, University of Aarhus, Aarhus C, Denmark
Free Radic Res 40:1230-8. 2006
..by the progressive accumulation of molecular damage caused by environmental and metabolically generated free radicals, by spontaneous errors in biochemical reactions, and by nutritional components...
- Cell signaling and receptors in toxicity of advanced glycation end products (AGEs): α-dicarbonyls, radicals, oxidative stress and antioxidants
Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA
J Recept Signal Transduct Res 31:332-9. 2011
..The toxic species have been related to illnesses and aging. Antioxidants alleviate the adverse effects...
- Free radicals, antioxidants, and neurologic injury: possible relationship to cerebral protection by anesthetics
John X Wilson
Department of Physiology, University of Western Ontario, London, Ontario, Canada
J Neurosurg Anesthesiol 14:66-79. 2002
Oxygen-centered free radicals cause brain injury associated with trauma and stroke. These reactive oxygen species may be detoxified by endogenous antioxidants, but cell death occurs after antioxidants become depleted...
- Free radicals and antioxidant systems in reflux esophagitis and Barrett's esophagus
Aragonés Institute of Health Sciences, and Gastroenterology Service, Lozano Blesa University Hospital Clinic, Avenida San Juan Bosco, C Domingo Miral, s n 15 50009 Zaragoza, Spain
World J Gastroenterol 11:2697-703. 2005
Experimental studies suggest that free radicals are involved in acid and pepsin-induced damage of esophageal mucosa. The profile and balance between free radicals and antioxidant systems in human esophagitis are unknown.
- Site-specific radical formation in DNA induced by Cu(II)-H₂O₂ oxidizing system, using ESR, immuno-spin trapping, LC-MS, and MS/MS
Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Free Radic Biol Med 50:1536-45. 2011
..The DMPO adduct formed is initially EPR active but subsequently is oxidized to the stable nitrone, which can then be detected by IST and further characterized by MS and MS/MS...
- Signaling functions of free radicals superoxide & nitric oxide under physiological & pathological conditions
Igor B Afanas'ev
Vitamin Research Institute, Moscow, Russia
Mol Biotechnol 37:2-4. 2007
Superoxide and nitric oxide are ubiquitous physiological free radicals that are responsible for many pathological disorders...
- Matrix metalloproteinases and free radicals in cerebral ischemia
K Jian Liu
College of Pharmacy, Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, 87131, USA
Free Radic Biol Med 39:71-80. 2005
..The proteases and free radicals involved are important, both individually and in concert, at each of the steps in the injury cascade...
- Potential markers of oxidative stress in stroke
Institute of Gerontology and Geriatrics, University of Perugia Medical School, Policlinico Monteluce Pad E, Via Brunamonti 51, 06122 Perugia, Italy
Free Radic Biol Med 39:841-52. 2005
..Since direct measurement of free radicals and oxidized molecules in the brain is difficult in humans, several biological substances have been ..
- Free radicals and antioxidants in primary fibromyalgia: an oxidative stress disorder?
Physical Medicine and Rehabilitation Department, Mersin University Medical School, Mersin, Turkey
Rheumatol Int 25:188-90. 2005
The role of free radicals in fibromyalgia is controversial. In this study, 85 female patients with primary fibromyalgia and 80 age-, height-, and weight-matched healthy women were evaluated for oxidant/antioxidant balance...
- On the generation of free radical species from quantum dots
Binil Itty Ipe
Biologisch Chemische Mikrostrukturtechnik, Fachbereich Chemie, Universitat Dortmund, Otto Hahn Str 6, 44227, Dortmund, Germany
Small 1:706-9. 2005
- The role of catechols and free radicals in benzene toxicity: an oxidative DNA damage pathway
Instituto Cajal, CSIC E 28002 Madrid, Spain
Environ Mol Mutagen 50:771-80. 2009
..In this review, we have addressed the cytotoxic effects of benzene and its main metabolite, catechol, focusing on the oxidative pathway and further DNA damage...
- Immunochemical detection of hemoglobin-derived radicals formed by reaction with hydrogen peroxide: involvement of a protein-tyrosyl radical
Dario C Ramirez
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27713, USA
Free Radic Biol Med 34:830-9. 2003
- Studies on free radicals, antioxidants, and co-factors
School of Biomolecular Sciences, Liverpool John Moores University, Liverpool, England, UK
Clin Interv Aging 2:219-36. 2007
The interplay between free radicals, antioxidants, and co-factors is important in maintaining health, aging and age-related diseases...
- The free radical theory of aging
University of Nebraska College of Medicine, Department of Medicine, Omaha, NE 68198 4635, USA
Antioxid Redox Signal 5:557-61. 2003
..Aging changes may be caused by free radical reactions. The extensive studies based on this possibility hold promise that the ALE-B can be extended to >85 years and the maximum life span increased...
- De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation
Laboratory for Experimental Medicine and Endocrinology, K U Leuven, Leuven, Belgium
Cancer Res 70:8117-26. 2010
..These findings provide important new insights into the role of de novo lipogenesis in cancer cells, and they provide a rationale for the use of lipogenesis inhibitors as antineoplastic agents and as chemotherapeutic sensitizers...
- tert-Butyl hydroperoxide-induced lipid signaling in hepatocytes: involvement of glutathione and free radicals
Department of Physiology, University of the Basque Country, E 48080, Bilbao, Spain
Biochem Pharmacol 62:705-12. 2001
..Results suggest that specific ROS generated in iron-dependent reactions, different from lipid peroxyl radicals, are involved in PLA(2) activation, this process being important in TBHP-induced hepatocyte injury...
- Biochemistry. Water photolysis in biology
A W Rutherford
Service of Bioenergetics, CNRS URA 2096, Departement de Biologie Joliot Curie, CEA Saclay, 91191 Gif sur Yvette, France
Science 303:1782-4. 2004
- Oxidative injury in epilepsy: potential for antioxidant therapy?
Daniel J Costello
Department of Clinical Neurological Sciences, Royal College of Surgeons of Ireland, Beaumont Hospital, Dublin, Ireland
Expert Rev Neurother 4:541-53. 2004
..This review examines the evidence for the role of oxidative injury in epilepsy, the rationale for use of antioxidant therapy in epilepsy and appraises the current clinical performance of the studies of antioxidant therapies...
- Ca2+-induced permeabilization promotes free radical release from rat brain mitochondria with partially inhibited complex I
Tatyana V Votyakova
Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Neurochem 93:526-37. 2005
..These results demonstrate that Ca2+ can greatly increase ROS release by brain mitochondria when complex I is impaired...
- Immune cells: free radicals and antioxidants in sepsis
Victor M Victor
Unidad Mixta Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III Universidad de Valencia, Avda Blasco Ibanez 15, 46010 Valencia, Spain
Int Immunopharmacol 4:327-47. 2004
..The potential clinical use of antioxidants in the treatment of sepsis and the effects on the redox state of the immune cells are discussed...
- Oxidative damage caused by free radicals produced during catecholamine autoxidation: protective effects of O-methylation and melatonin
J W Miller
Vitamin Bioavailability Laboratory, Jean Mayer, USDA Human Nutrition Research Center on Aging, Tufts University, USA
Free Radic Biol Med 21:241-9. 1996
..and (2) melatonin, which has recently been shown to be a powerful antioxidant, is capable of scavenging free radicals produced during catecholamine autoxidation...
- Oxidative stress and antioxidants in exercise
Center for Exercise Science, Aging Biochemistry Laboratory, College of Health and Human Performance, University of Florida, Gainesville, FL 32611, USA
Curr Med Chem 8:829-38. 2001
..These include increased antioxidant defenses, reduced basal production of oxidants, and reduction of radical leak during oxidative phosphorylation...
- Identification of free radicals on hemoglobin from its self-peroxidation using mass spectrometry and immuno-spin trapping: observation of a histidinyl radical
Leesa J Deterding
Laboratory of Structural Biology, Laboratory of Pharmacology and Chemistry, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 279:11600-7. 2004
..To verify that DMPO adducts of the protein free radicals had been formed, the reaction mixtures were analyzed by flow injection electrospray ionization mass ..
- Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease
Hui Ming Gao
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
FASEB J 17:1954-6. 2003
..This study also suggests that NADPH oxidase may be a promising target for therapeutic interventions in Parkinson's disease...
- Role of free radicals in the pathogenesis of acute chest syndrome in sickle cell disease
E S Klings
The Pulmonary Center, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Respir Res 2:280-5. 2001
..The present review summarizes the evidence for alterations in oxidant stress during ACS of SCD, and the potential contributions of RBCs, WBCs and the vascular endothelium to this process...
- Oxidative stress and diabetic cardiovascular complications
Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA 30322, USA
Free Radic Biol Med 40:183-92. 2006
..The elucidation of the mechanisms of oxidative stress in diabetes and their relationship with atherosclerosis could potentially identify molecular targets of therapy for this condition and its cardiovascular consequences...
- Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity
Saibal K Biswas
Centre for Cardiovascular Sciences, School of Biomedical and Clinical Laboratory Sciences, University of Edinburgh, Medical School, Edinburgh, UK
Antioxid Redox Signal 7:32-41. 2005
..This suggests that curcumin has multiple properties: as an oxygen radical scavenger, antioxidant through modulation of glutathione levels, and antiinflammatory agent through inhibition of IL-8 release in lung cells...
- The role of free radicals in cerebral hypoxia and ischemia
Department of Neuroanatomy and Cell Biology, Instituto Cajal, CSIC, Madrid, Spain
Free Radic Biol Med 39:26-50. 2005
..Unfortunately, in many cases this response becomes excessive and it triggers a cascade of free-radical reactions, leading to modifications of cerebral plasticity and overt injury...
- Reactive carbonyls and oxidative stress: potential for therapeutic intervention
Elizabeth M Ellis
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 204 George Street, Glasgow, G1 1XW, United Kingdom
Pharmacol Ther 115:13-24. 2007
..This review describes the metabolism of reactive carbonyls and discusses the potential for manipulating levels of carbonyl-metabolizing enzymes through chemical intervention...
- Effects of propolis on blood glucose, blood lipid and free radicals in rats with diabetes mellitus
H U Fuliang
College of Animal Science, Zhejiang University, Hangzhou 310029, China
Pharmacol Res 51:147-52. 2005
..EEP) and water (WSD) extracts of propolis collected from north China on blood glucose, blood lipid and free radicals in rats with diabetes mellitus were studied...
- Enzymology of the repair of free radicals-induced DNA damage
Groupe Réparation de l ADN, UMR 8532 CNRS, LBPA ENS Cachan, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex, France
Oncogene 21:8905-25. 2002
..This review is focused on the repair of lesions induced by free radicals and ionising radiation...
- Ascorbic acid: much more than just an antioxidant
Dipartimento di Biologia e Patologia Vegetale, Universita di Bari, Via E Orabona 4, 70125 Bari, Italy
Biochim Biophys Acta 1569:1-9. 2002
- Free radicals as triggers of brain edema formation after stroke
Ji Hoe Heo
Department of Neurology, National Core Research Center for Nanomedical Technology, Brain Korea 21 Project for Medical Sciences, Seoul
Free Radic Biol Med 39:51-70. 2005
..b>Free radicals exert their deleterious actions during both cytotoxic and vasogenic edema...
- Free radicals in breast carcinogenesis, breast cancer progression and cancer stem cells. Biological bases to develop oxidative-based therapies
Department of Oncology, Complejo Hospitalario de Jaen, Avenida del Ejercito Español s n, Jaen, Spain
Crit Rev Oncol Hematol 80:347-68. 2011
..To survive, cancer cells must acquire adaptive mechanisms that counteract the toxic effects of free radicals exposure...
- Scavenging free radicals improves endothelial dysfunction in human coronary arteries in vivo
Jun ichi Oyama
Department of Cardiovascular, Respiratory, and Geriatric Medicine, Kyushu University Hospital at Beppu and Medical Institute of Bioregulation, Kyushu University, Oita, Japan
Heart Vessels 25:379-85. 2010
..was examined in patients who had no significant stenosis of coronary arteries, to elucidate the role of free radicals on coronary endothelial dysfunction...
- Pesticides and oxidative stress: a review
Department of Toxicology and Pharmacology, Faculty of Pharmacy and Laboratory of Toxicology, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14155 6451, Iran
Med Sci Monit 10:RA141-7. 2004
- Immuno-spin trapping of a post-translational carboxypeptidase B1 radical formed by a dual role of xanthine oxidase and endothelial nitric oxide synthase in acute septic mice
Free Radical Metabolites Group, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Free Radic Biol Med 46:454-61. 2009
..This suggests the presence of a possible mechanism for CPB1 activity loss with compensatory protein production...
- Interaction of free radicals, matrix metalloproteinases and caveolin-1 impacts blood-brain barrier permeability
School of Chinese Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
Front Biosci (Schol Ed) 3:1216-31. 2011
b>Free radicals play an important role in cerebral ischemia-reperfusion injury...
- Antioxidant and antiacetylcholinesterase activities of chard (Beta vulgaris L. var. cicla)
Department of Chemistry, Faculty of Engineering, Istanbul University, Avcilar Istanbul, Turkey
Food Chem Toxicol 48:1275-80. 2010
..The results were compared with natural and synthetic antioxidants. The results suggest that chard may provide a natural source of antioxidant and antiacetylcholinesterase activities and proline content...
- Fatty liver induced by free radicals and lipid peroxidation
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Japan
Free Radic Res 46:758-65. 2012
..These results show that free radicals as well as high fat diet induce fatty liver by similar mechanisms, in which lipid peroxidation may be involved.
- An oxygen radical absorbance capacity-like assay that directly quantifies the antioxidant's scavenging capacity against AAPH-derived free radicals
School of Health Sciences, Sapporo Medical University, Sapporo, South 1 West 17, Chuo Ku, Sapporo, Hokkaido 060 8556, Japan
Anal Biochem 386:167-71. 2009
..The new ORAC assay employs a short in situ photolysis of AAPH to generate free radicals. The electron paramagnetic resonance (EPR) spin trapping method was employed to identify and quantify AAPH ..
- The role of melanin as protector against free radicals in skin and its role as free radical indicator in hair
Department of Medical Physics, University of Applied Sciences TFH Berlin, Luxemburger Strasse 10, 13353 Berlin, Germany
Spectrochim Acta A Mol Biomol Spectrosc 69:1429-35. 2008
..Additional extrinsic free radicals are reversibly photo-generated by UV and visible light...
- Analysis of acid-stressed Bacillus cereus reveals a major oxidative response and inactivation-associated radical formation
Top Institute Food and Nutrition, Wageningen, The Netherlands
Environ Microbiol 12:873-85. 2010
..cereus strains in bactericidal conditions only. Our study shows that radicals can indicate acid-induced malfunctioning of cellular processes that lead to cell death...
- Free radicals: their beneficial and detrimental effects on sperm function
Center for Reproductive Medicine, Cleveland Clinic, 9500 Euclid Avenue, Desk A19 1, Cleveland, Ohio 44195, USA
Indian J Exp Biol 48:425-35. 2010
b>Free radicals are molecules with one or more unpaired electron(s) commonly found in seminal plasma. Physiologically, free radicals control sperm maturation, capacitation and hyperactivation, the acrosome reaction, and sperm-oocyte fusion...
- Tyrosyl radicals in proteins: a comparison of empirical and density functional calculated EPR parameters
Dimitri A Svistunenko
Department of Biological Sciences, University of Essex, Essex, Colchester, UK
Phys Chem Chem Phys 11:6600-13. 2009
..Therefore, it is suggested that a full correlation between the calculated and the algorithm-derived empirical EPR parameters might be achieved when water molecules are included in the calculation model...
- Reaction of Mycobacterium tuberculosis truncated hemoglobin O with hydrogen peroxide: evidence for peroxidatic activity and formation of protein-based radicals
Department of Biochemistry and Microbiology, Laval University, Quebec G1K 7P4, Canada
J Biol Chem 282:7491-503. 2007
..These findings suggest an oxidation/reduction function for trHbO and, by analogy, for other Group II trHbs...
- The impact of oxygen availability on stress survival and radical formation of Bacillus cereus
Top Institute Food and Nutrition, Wageningen, The Netherlands Laboratory of Food Microbiology, Wageningen University, Wageningen, The Netherlands
Int J Food Microbiol 135:303-11. 2009
..cereus, in food industry related conditions is investigated, because oxygen availability may affect the efficiency of food preservation conditions...
- Membrane "lens" effect: focusing the formation of reactive nitrogen oxides from the *NO/O2 reaction
Matías N Möller
Laboratorio de Fisicoquímica Biológica, Facultad de Ciencias, and Center for Free Radical and Biomedical Research, Universidad de la Republica, Montevideo 11400, Uruguay
Chem Res Toxicol 20:709-14. 2007
- PLA2 mediated arachidonate free radicals: PLA2 inhibition and neutralization of free radicals by anti-oxidants--a new role as anti-inflammatory molecule
B L Nanda
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, India
Curr Top Med Chem 7:765-77. 2007
..Thus PLA2 catalyzes the rate-limiting step in the production of pro-inflammatory eicosanoids and free radicals. These peroxides and reactive oxygen species in turn activates PLA2 enzyme and further attenuates the ..
- In vivo detection of free radicals induced by diethylnitrosamine in rat liver tissue
Ken ichi Yamada
Department of Bio function Science, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Free Radic Biol Med 40:2040-6. 2006
..The aim of this study was to use in vivo spin trapping and spin probe techniques to investigate whether free radicals are generated in rat liver tissue during DEN activation...
- An active dimanganese(III)-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase
Joseph A Cotruvo
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Biochemistry 49:1297-309. 2010
..We propose that NrdI is an essential player in E. coli class Ib RNR cluster assembly and that the Mn(III)(2)-Y* cofactor, not the diferric-Y* one, is the active metallocofactor in vivo...
- Oxygen free radicals and contrast nephropathy
R E Katholi
Prairie Education Research Cooperative, Springfield, IL, USA
Am J Kidney Dis 32:64-71. 1998
..To test the hypothesis that oxygen free radicals (produced during intrarenal adenosine catabolism to xanthine) should be implicated in the pathogenesis of ..
- Side chain chemistry mediates backbone fragmentation in hydrogen deficient peptide radicals
Department of Chemistry, University of California, Riverside, California 92521, USA
J Proteome Res 8:958-66. 2009
- Alzheimer disease and the role of free radicals in the pathogenesis of the disease
Paula I Moreira
Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, 3004 517 Coimbra, Portugal
CNS Neurol Disord Drug Targets 7:3-10. 2008
..However, during the progression of the disease, the antioxidant activity of both agents is either overwhelmed or, according to others, evolves into pro-oxidant activity resulting in the exacerbation of reactive species production...
- Tobacco smoke carcinogens and lung cancer
S S Hecht
University of Minnesota Cancer Center, Minneapolis 55455, USA
J Natl Cancer Inst 91:1194-210. 1999
..also discussed, as are inhalation studies of tobacco smoke in laboratory animals and the potential role of free radicals and oxidative damage in tobacco-associated carcinogenesis...
- Free radicals in biology and medicine: from inflammation to biotechnology
Okezie I Aruoma
Faculty of Health and Social Care, London South Bank University, 103 Borough Road, London, UK
Biofactors 27:1-3. 2006
- What an andrologist/urologist should know about free radicals and why
Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Glickman Urological Institute, Cleveland, Ohio 44195, USA
Urology 67:2-8. 2006
- Bacillus subtilis class Ib ribonucleotide reductase is a dimanganese(III)-tyrosyl radical enzyme
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Biochemistry 50:5615-23. 2011
..5 Y(•)/β(2) and an activity of 318-363 nmol min(-1) mg(-1) (normalized for 1 Y(•)/β(2)). These data strongly suggest that the B. subtilis class Ib RNR is a Mn(III)(2)-Y(•) enzyme...
- Free radicals generated by contracting muscle: by-products of metabolism or key regulators of muscle function?
Malcolm J Jackson
Division of Metabolic and Cellular Medicine, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
Free Radic Biol Med 44:132-41. 2008
- Free radicals and exercise: an introduction
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
Free Radic Biol Med 44:123-5. 2008
- Chapter 9: Oxidative stress in malignant progression: The role of Clusterin, a sensitive cellular biosensor of free radicals
Ioannis P Trougakos
Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis Zografou, Athens 15784, Greece
Adv Cancer Res 104:171-210. 2009
..This review focuses on CLU regulation by oxidative injury that is the common molecular link of most, if not all, pathological conditions where CLU has been functionally implicated...
- Metals, toxicity and oxidative stress
Faculty of Chemical and Food Technology, Slovak Technical University, SK 812 37 Bratislava, Slovakia
Curr Med Chem 12:1161-208. 2005
..Metal-mediated formation of free radicals causes various modifications to DNA bases, enhanced lipid peroxidation, and altered calcium and sulfhydryl ..
- Effects of amelioration of total flavonoids from stems and leaves of Scutellaria baicalensis Georgi on cognitive deficits, neuronal damage and free radicals disorder induced by cerebral ischemia in rats
Ya Zhen Shang
Institute of Traditional Chinese Medicine, Chengde Medical College, China
Biol Pharm Bull 29:805-10. 2006
..The present study examined whether TFSS can improve memory dysfunction, neuronal damage, and abnormal free radicals induced by permanent cerebral ischemia in rats...
- Sensitivity of tyrosyl radical g-values to changes in protein structure: a high-field EPR study of mutants of ribonucleotide reductase
, , CNRS URA2096, CEA Saclay, F-91191 Gif-sur-Yvette, France
J Am Chem Soc 123:3048-54. 2001
..Using existing tyrosyl radical g-tensor measurements, we have developed a simple effective charge model that allows us to rationalize the effect of the local electrostatic environments in a number of proteins...
- beta-amyloid protein enhances macrophage production of oxygen free radicals and glutamate
Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada
J Neurosci Res 49:229-35. 1997
..Such mechanisms could contribute to the pathogenesis of neurodegenerative disorders, including Alzheimer's disease...
- Microsomal metabolism of ciprofloxacin generates free radicals
Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara, Turkey
Free Radic Biol Med 30:1118-21. 2001
..The generation of 4-POBN/radical adduct is dependent on the presence of NADPH, CPFX, and active microsomes. Furthermore, free radical production is completely inhibited by SKF 525A, Trolox, or ZnCl2...
- Free radicals in Parkinson's disease
Clinical Neurochemistry and NPF Center of Excellence Research Laboratory, Department of Psychiatry and Psychotherapy, Julius Maximilians University, Fuechsleinstr 15, 97080 Wuerzburg, Germany
J Neurol 249:II1-5. 2002
..toxin-induced neurodegeneration can be blocked by antioxidants, and 5) Activated microglia, known to release free radicals and inflammatory cytokines, are present in brains of Parkinsonian patients...
- Oxalate and calcium oxalate mediated free radical toxicity in renal epithelial cells: effect of antioxidants
Department of Urology 2D, Vattikuti Urology Institute and Henry Ford Health Sciences Center, One Ford Place, Detroit, MI 48202, USA
Urol Res 31:3-9. 2003
..Antioxidant administration may prevent calcium oxalate nucleation and retention in the renal tubules by preventing oxalate mediated peroxidative injury...
- Examples of high-frequency EPR studies in bioinorganic chemistry
K Kristoffer Andersson
Department of Biochemistry, University of Oslo, Blindern, PO Box 1041, 0316, Oslo, Norway
J Biol Inorg Chem 8:235-47. 2003
..GHz and magnetic fields up to 12 T has been used to study metal sites in proteins or inorganic complexes and free radicals. The high-field EPR method was used to resolve g-value anisotropy by separating it from overlapping hyperfine ..
- The tandem of free radicals and methylglyoxal
Miklos Peter Kalapos
Theoretical Biology Research Group, Budapest, Hungary
Chem Biol Interact 171:251-71. 2008
..Recently, the attention has been focused on the involvement of free radicals in methylglyoxal toxicity...
- Delayed production of free radicals following noise exposure
Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI, USA
Brain Res 1019:201-9. 2004
..slowly progressing apoptotic or necrosis pathways, an alternate hypothesis is that a continued formation of free radicals contributes to cell death...
- Free radicals, chemokines, and cell injury in HIV-1 and SIV infections and alcoholic hepatitis
A P Bautista
Department of Physiology and NIAAA Sponsored Alcohol Research Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Free Radic Biol Med 31:1527-32. 2001