helium

Summary

Summary: Helium. A noble gas with the atomic symbol He, atomic number 2, and atomic weight 4.003. It is a colorless, odorless, tasteless gas that is not combustible and does not support combustion. It was first detected in the sun and is now obtained from natural gas. Medically it is used as a diluent for other gases, being especially useful with oxygen in the treatment of certain cases of respiratory obstruction, and as a vehicle for general anesthetics. (Dorland, 27th ed)

Top Publications

  1. ncbi The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury
    Mark Coburn
    Biophysics Section, Blackett Laboratory, Imperial College, South Kensington, London SW7 2AZ, UK
    Crit Care Med 36:588-95. 2008
  2. ncbi Post-ischemic helium provides neuroprotection in rats subjected to middle cerebral artery occlusion-induced ischemia by producing hypothermia
    Helene N David
    NNOXe Pharmaceuticals, Quebec City, Quebec, Canada
    J Cereb Blood Flow Metab 29:1159-65. 2009
  3. ncbi Inert gas washout: theoretical background and clinical utility in respiratory disease
    Paul D Robinson
    Department of Respiratory Medicine, Children s Hospital at Westmead, Sydney, NSW, Australia
    Respiration 78:339-55. 2009
  4. ncbi Demonstration of the heterogeneous distribution of asthma in the lungs using CT and hyperpolarized helium-3 MRI
    Ravi Aysola
    University of California Los Angeles Medical Center, Department of Medicine, Pulmonary and Critical Care Medicine, Los Angeles, California, USA
    J Magn Reson Imaging 32:1379-87. 2010
  5. ncbi Prognostic factors and recurrence of hepatitis B-related hepatocellular carcinoma after argon-helium cryoablation: a prospective study
    Chunping Wang
    Center of Therapeutic Research for Hepatocellular Carcinoma, 100039 Beijing, China
    Clin Exp Metastasis 26:839-48. 2009
  6. ncbi Noble gases without anesthetic properties protect myocardium against infarction by activating prosurvival signaling kinases and inhibiting mitochondrial permeability transition in vivo
    Paul S Pagel
    Department of Anesthesiology, The Medical College of Wisconsin and the Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295, USA
    Anesth Analg 105:562-9. 2007
  7. ncbi Overall and peripheral inhomogeneity of ventilation in patients with stable cystic fibrosis
    A Van Muylem
    Department of Chest Medicine, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Pediatr Pulmonol 30:3-9. 2000
  8. ncbi Helium-hyperoxia: a novel intervention to improve the benefits of pulmonary rehabilitation for patients with COPD
    Neil D Eves
    Faculty of Kinesiology and the Division of Respiratory Medicine, Faculty of Medicine, University of Calgary, 2500 University Drive NW, Calgary, Alberta, Canada
    Chest 135:609-18. 2009
  9. ncbi Effect of heliox, oxygen and air breathing on helium bubbles after heliox diving
    O Hyldegaard
    Laboratory ofHyperbaric Medicine, Department of Anaesthesia, Centre of Head and Orthopaedics, Rigshospitalet, Copenhagen University Hospital, Denmark
    Undersea Hyperb Med 34:107-22. 2007
  10. ncbi Neuroprotection (and lack of neuroprotection) afforded by a series of noble gases in an in vitro model of neuronal injury
    Noorulhuda Jawad
    Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom
    Neurosci Lett 460:232-6. 2009

Research Grants

  1. High-Tc susceptometer to monitor transfusional iron overload (NSR device)
    Gary M Brittenham; Fiscal Year: 2010
  2. ELECTRON MICROSCOPIC STUDIES OF THE CRYSTALLINE LENS
    J Kuszak; Fiscal Year: 2002
  3. ADVANCED ELECTRON MICROSCOPIC STUDIES OF CRYSTALLINE LEN
    J Kuszak; Fiscal Year: 1999
  4. HE3 MR Diffusion & Low Dose CT Quantitation of Emphysema
    David Gierada; Fiscal Year: 2005
  5. Respiratory Mechanics in Lung Disease and Surgery
    Stephen Loring; Fiscal Year: 2004
  6. A Freeze-Fracture & Etching System for Northwestern Univ
    Mark Johnson; Fiscal Year: 2002
  7. Imaging regional physiologic parameters of lung function
    Rahim Rizi; Fiscal Year: 2009
  8. Imaging regional physiologic parameters of lung function
    Rahim R Rizi; Fiscal Year: 2010
  9. STRUCTURE AND DYNAMICS OF CONNEXIN26 GAP JUNCTIONS
    GINA SOSINSKY; Fiscal Year: 2007
  10. ELECTRON MICROSCOPIC STUDIES OF CRYSTALLINE LENSES
    J Kuszak; Fiscal Year: 1993

Detail Information

Publications286 found, 100 shown here

  1. ncbi The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury
    Mark Coburn
    Biophysics Section, Blackett Laboratory, Imperial College, South Kensington, London SW7 2AZ, UK
    Crit Care Med 36:588-95. 2008
    ..The "inert" gas xenon has been shown to be an effective neuroprotectant in a variety of in vitro and in vivo models of neuronal injury. We examined its neuroprotective properties in an in vitro model of traumatic brain injury...
  2. ncbi Post-ischemic helium provides neuroprotection in rats subjected to middle cerebral artery occlusion-induced ischemia by producing hypothermia
    Helene N David
    NNOXe Pharmaceuticals, Quebec City, Quebec, Canada
    J Cereb Blood Flow Metab 29:1159-65. 2009
    ..Interestingly, recent findings have shown that helium, which is a cost-efficient inert gas with no anesthetic properties, can provide neuroprotection against acute ..
  3. ncbi Inert gas washout: theoretical background and clinical utility in respiratory disease
    Paul D Robinson
    Department of Respiratory Medicine, Children s Hospital at Westmead, Sydney, NSW, Australia
    Respiration 78:339-55. 2009
    ....
  4. ncbi Demonstration of the heterogeneous distribution of asthma in the lungs using CT and hyperpolarized helium-3 MRI
    Ravi Aysola
    University of California Los Angeles Medical Center, Department of Medicine, Pulmonary and Critical Care Medicine, Los Angeles, California, USA
    J Magn Reson Imaging 32:1379-87. 2010
    ..Thus, cross sectional imaging in asthma is providing new insights into the pathophysiology of the disease and has the potential to become essential in the guidance of localized treatments...
  5. ncbi Prognostic factors and recurrence of hepatitis B-related hepatocellular carcinoma after argon-helium cryoablation: a prospective study
    Chunping Wang
    Center of Therapeutic Research for Hepatocellular Carcinoma, 100039 Beijing, China
    Clin Exp Metastasis 26:839-48. 2009
    To determine the long-term prognosis of hepatocellular carcinoma (HCC) after argon-helium cryoablation and identify the risk factors that predict metastasis and recurrence...
  6. ncbi Noble gases without anesthetic properties protect myocardium against infarction by activating prosurvival signaling kinases and inhibiting mitochondrial permeability transition in vivo
    Paul S Pagel
    Department of Anesthesiology, The Medical College of Wisconsin and the Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295, USA
    Anesth Analg 105:562-9. 2007
    ..We hypothesized that other noble gases without anesthetic properties [helium (He), neon (Ne), argon (Ar)] also produce cardioprotection, and further hypothesized that this beneficial effect ..
  7. ncbi Overall and peripheral inhomogeneity of ventilation in patients with stable cystic fibrosis
    A Van Muylem
    Department of Chest Medicine, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Pediatr Pulmonol 30:3-9. 2000
    ..washout consisting of 1 L inspired from functional residual capacity (FRC test) of 90% oxygen (O(2)), 5% helium (He), and 5% sulfur hexafluoride (SF(6))...
  8. ncbi Helium-hyperoxia: a novel intervention to improve the benefits of pulmonary rehabilitation for patients with COPD
    Neil D Eves
    Faculty of Kinesiology and the Division of Respiratory Medicine, Faculty of Medicine, University of Calgary, 2500 University Drive NW, Calgary, Alberta, Canada
    Chest 135:609-18. 2009
    b>Helium-hyperoxia (HH) reduces dyspnea and increases exercise tolerance in patients with COPD...
  9. ncbi Effect of heliox, oxygen and air breathing on helium bubbles after heliox diving
    O Hyldegaard
    Laboratory ofHyperbaric Medicine, Department of Anaesthesia, Centre of Head and Orthopaedics, Rigshospitalet, Copenhagen University Hospital, Denmark
    Undersea Hyperb Med 34:107-22. 2007
    In helium saturated rat abdominal adipose tissue, helium bubbles were studied at 101.3 kPa during breathing of either heliox(80:20), 100% oxygen or air after decompression from an exposure to heliox at 405 kPa for one hour...
  10. ncbi Neuroprotection (and lack of neuroprotection) afforded by a series of noble gases in an in vitro model of neuronal injury
    Noorulhuda Jawad
    Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom
    Neurosci Lett 460:232-6. 2009
    ..In this study, the neuroprotective properties of the other noble gases, namely, krypton, argon, neon and helium, were explored in an in vitro model of neuronal injury...
  11. ncbi Psychophysiological reactions in humans during an open sea dive to 500 m with a hydrogen-helium-oxygen mixture
    J H Abraini
    Laboratoire de Physiopathologie Intégrée et Cellulaire, Centre National de la Recherche Scientifique, Faculte de Medecine Nord, Marseille, France
    J Appl Physiol 76:1113-8. 1994
    ..investigated for neurological and psychosensorimotor responses during an open sea dive to 500 m with a hydrogen-helium-oxygen mixture containing 49% hydrogen...
  12. ncbi Sterilization of bacteria, yeast, and bacterial endospores by atmospheric-pressure cold plasma using helium and oxygen
    Kyenam Lee
    Department of Biology, College of Natural Sciences, Seoul Women's University, Seoul 139-774, Republic of Korea
    J Microbiol 44:269-75. 2006
    Atmospheric-pressure cold plasma (APCP) using helium/oxygen was developed and tested as a suitable sterilization method in a clinical environment...
  13. ncbi Heliox and oxygen reduce infarct volume in a rat model of focal ischemia
    Yi Pan
    Department of Neurology, Saint Louis University Hospital, 3635 Vista Ave, Saint Louis, MO 63110, USA
    Exp Neurol 205:587-90. 2007
    ..rats breathed 30% oxygen and 70% nitrogen (control group), 100% oxygen (hyperoxia group), or 30% oxygen and 70% helium (heliox group) during a middle cerebral artery occlusion for 2 h and a 1-hour reperfusion (n=6 in each group)...
  14. ncbi Peripheral airway involvement in asthma assessed by single-breath SF6 and He washout
    P M Gustafsson
    Dept of Paediatrics, Central Hospital, Skovde, Sweden
    Eur Respir J 21:1033-9. 2003
    ..Peripheral airway function was measured using a single-breath sulphur hexafluoride (SF6) and helium (He) washout test and overall airway function by forced expiratory volume in one second (FEV1) at rest, after CACh ..
  15. ncbi Helium-neon laser irradiation stimulates cell proliferation through photostimulatory effects in mitochondria
    Wan Ping Hu
    Faculty of Biotechnology and Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Invest Dermatol 127:2048-57. 2007
    ..Recent evidence indicates that cellular proliferation could be triggered by the interaction of a helium-neon laser (He-Ne laser, 632.8 nm) with the mitochondrial photoacceptor-cytochrome c oxidase...
  16. ncbi Formation and properties of metal clusters isolated in helium droplets
    Josef Tiggesbäumker
    Institut fur Physik, Universitat Rostock, 18051, Rostock, Germany
    Phys Chem Chem Phys 9:4748-70. 2007
    The unique conditions forming atomic and molecular complexes and clusters using superfluid helium nanodroplets have opened up an innovative route for studying the physical and chemical properties of matter on the nanoscale...
  17. ncbi Initial yields of DNA double-strand breaks and DNA Fragmentation patterns depend on linear energy transfer in tobacco BY-2 protoplasts irradiated with helium, carbon and neon ions
    Yuichiro Yokota
    Gene Resource Research Group, Quantum Beam Science Directorate, Japan Atomic Energy Agency, Takasaki, Gunma 370 1292, Japan
    Radiat Res 167:94-101. 2007
    ..Tobacco BY-2 protoplasts, as a model of single plant cells, were irradiated with helium, carbon and neon ions having different LETs and with gamma rays...
  18. ncbi Pulmonary ventilation and perfusion scanning using hyperpolarized helium-3 MRI and arterial spin tagging in healthy normal subjects and in pulmonary embolism and orthotopic lung transplant patients
    David A Lipson
    Division of Pulmonary, Allergy and Critical Care Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 47:1073-6. 2002
    ..The acquisition of pulmonary V/Q images using MRI overcomes these difficulties. When inhaled, hyperpolarized helium-3 ((3)He) permits MRI of gas distribution...
  19. ncbi Effects of helium/oxygen and temperature on aerobic metabolism in the marsupial sugar glider, Petaurus breviceps
    J C Holloway
    Department of Zoology, School of Biological Sciences, University of New England, Armidale, New South Wales 2351, Australia
    Physiol Biochem Zool 74:219-25. 2001
    Helox (79% helium and 21% oxygen) has often been used for thermobiological studies, primarily because helium is thought to be metabolically inert and to produce no adverse effects other than increasing heat loss...
  20. ncbi Pulmonary embolism: comprehensive evaluation with MR ventilation and perfusion scanning with hyperpolarized helium-3, arterial spin tagging, and contrast-enhanced MRA
    Talissa A Altes
    Department of Radiology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Vasc Interv Radiol 16:999-1005. 2005
    ..MR ventilation imaging was performed after the inhalation of hyperpolarized helium-3...
  21. ncbi Cs atoms on helium nanodroplets and the immersion of Cs+ into the nanodroplet
    Moritz Theisen
    Institute of Experimental Physics, Graz University of Technology, Petersgasse 16, A 8010 Graz, Austria
    J Chem Phys 135:074306. 2011
    We report the non-desorption of cesium (Cs) atoms on the surface of helium nanodroplets (He(N)) in their 6(2)P(1/2) ((2)Π(1/2)) state upon photo-excitation as well as the immersion of Cs(+) into the He(N) upon photo-ionization via the 6(..
  22. ncbi Measurement of lung airways in three dimensions using hyperpolarized helium-3 MRI
    Eric T Peterson
    Department of Biomedical Engineering, University of Wisconsin Madison, Madison, WI, USA
    Phys Med Biol 56:3107-22. 2011
    ..radiation from CT, we present a method for measuring the large airway diameter in humans using hyperpolarized helium-3 (HPHe) MRI in conjunction with a dynamic 3D radial acquisition...
  23. ncbi Comparison of plethysmographic and helium dilution lung volumes: which is best for COPD?
    Carl R O'Donnell
    ScD, Beth Israel Deaconess Medical Center, Dana 717, 330 Brookline Ave, Boston, MA 02215, USA
    Chest 137:1108-15. 2010
    ..We sought to compare plethysmography (Pleth)-, helium dilution (He)- and CT scan-derived lung volume measurements in a sample containing many patients with severe ..
  24. ncbi Microleakage of gold casting repairs with different materials as quantified by a helium gas system
    B Briseno Marroquin
    Department of Conservative Dentistry, Johannes Gutenberg University, Mainz, Germany
    Oper Dent 20:197-203. 1995
    ..Tetric, Charisma, and Polofil Molar), and one glass-ionomer cement (Ketac Silver) and gold cast crowns using a helium gas microleakage method...
  25. ncbi Recent trends in suicides utilizing helium
    Amy Austin
    Discipline of Anatomy and Pathology, Level 3 Medical School North Building, The University of Adelaide, Frome Road and Forensic Science SA, Adelaide, SA 5005, Australia
    J Forensic Sci 56:649-51. 2011
    Retrospective review of cases of suicide involving helium inhalation was undertaken at Forensic Science South Australia over a 25-year period from 1985 to 2009...
  26. ncbi Alkali-helium snowball complexes formed on helium nanodroplets
    S Muller
    Physikalisches Institut, Universitat Freiburg, 79104 Freiburg, Germany
    J Chem Phys 131:044319. 2009
    ..the formation and stability of snowballs formed by femtosecond photoionization of small alkali clusters bound to helium nanodroplets...
  27. ncbi Morphine reduces the threshold of helium preconditioning against myocardial infarction: the role of opioid receptors in rabbits
    Paul S Pagel
    Department of Anesthesiology, Medical College of Wisconsin and Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, WI, USA
    J Cardiothorac Vasc Anesth 23:619-24. 2009
    Brief, repetitive administration of helium before prolonged coronary artery occlusion and reperfusion protects myocardium against infarction...
  28. ncbi Cellular effects of helium in different organs
    Gezina T M L Oei
    Department of Anesthesiology, Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Anesthesiology 112:1503-10. 2010
    ..in cardiac and neuronal tissue has shown that besides volatile anesthetics and xenon, the nonanesthetic noble gas helium also reduces ischemia-reperfusion damage...
  29. ncbi Low-energy helium-neon laser induces locomotion of the immature melanoblasts and promotes melanogenesis of the more differentiated melanoblasts: recapitulation of vitiligo repigmentation in vitro
    Cheng-Che E Lan
    Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Taiwan, ROC
    J Invest Dermatol 126:2119-26. 2006
    b>Helium-neon laser (He-Ne Laser, 632.8 nm) is a low-energy laser that has therapeutic efficacy on various clinical conditions...
  30. ncbi Obtaining high-resolution images of biological macromolecules by using a cryo-electron microscope with a liquid-helium cooled stage
    Kaoru Mitsuoka
    National Institute of Advanced Industrial Science and Technology, Biomedicinal Information Research Center, 2 3 26, Aomi, Koto ku, Tokyo 135 0064, Japan
    Micron 42:100-6. 2011
    ..for high-resolution imaging in these three different methods, based on our experiences using cryo-EM with a liquid-helium cooled stage...
  31. ncbi A helium burst biolistic device adapted to penetrate fragile insect tissues
    J L Thomas
    Unité Nationale Séricicole, INRA, 25 quai J J Rousseau, 69350 La Mulatière, France
    J Insect Sci 1:9. 2001
    ..The original floppy macrocarrier was replaced by a rigid macrocarrier to avoid the effects of the helium blast. The efficiency of the gene gun bombardment was reinforced by the addition of a focusing nozzle...
  32. ncbi Microdialysis study of striatal dopaminergic dysfunctions induced by 3 MPa of nitrogen- and helium-oxygen breathing mixtures in freely moving rats
    David Dedieu
    Laboratoire de Physiopathologie et Action Thérapeutique des gaz sous pression, Faculte de Medecine Nord, Université de la Méditerranée et IMNSSA, E A 3280, IFR Jean Roche, 13916 Marseilles cedex 20, France
    Brain Res 998:202-7. 2004
    Previous studies have demonstrated opposite effects of high-pressure helium and nitrogen on extracellular dopamine (DA) levels, which may reflect disturbances on the synthesis, release or metabolic mechanisms...
  33. ncbi Song syntax changes in Bengalese finches singing in a helium atmosphere
    Hiroko Yamada
    Graduate School of Science and Technology, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan
    Neuroreport 14:1725-9. 2003
    ..Eight adult male Bengalese finches were placed in a helium atmosphere, which changes the resonance of the vocal tract...
  34. ncbi High-resolution differential ion mobility separations using helium-rich gases
    Alexandre A Shvartsburg
    Biological Sciences Division, Pacific Northwest National Laboratory, P O Box 999, Richland, Washington 99352, USA
    Anal Chem 82:2456-62. 2010
    ..The resolution gains extend to small molecules, where previously unresolved isomers can now be separated. These performance levels open major new applications of FAIMS in proteomic and other biomolecular analyses...
  35. ncbi Pulmonary gas exchange in anaesthetised horses mechanically ventilated with oxygen or a helium/oxygen mixture
    F Staffieri
    Section of Critical Care and Anesthesia, Department of Clinical Studies New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, USA
    Equine Vet J 41:747-52. 2009
    ..It is unknown whether administration of gas-mixtures high in inspired fraction of oxygen (FiO2) under general anaesthesia may increase formation of pulmonary atelectasis and impair gas exchange...
  36. ncbi The Effects of helium/oxygen mixture (heliox) before and after extubation in long-term mechanically ventilated very low birth weight infants
    Claudio Migliori
    Department of Neonatology and Neonatal Intensive Care, Spedali Civili Hospital, P le Spedali Civili, 25123 Brescia, Italy
    Pediatrics 123:1524-8. 2009
    Our goal was to evaluate the effects of a helium/oxygen mixture (heliox) on pulmonary mechanics and gas exchange in preterm infants during both conventional and noninvasive ventilation.
  37. ncbi Helium breathing provides modest antiinflammatory, but no endothelial protection against ischemia-reperfusion injury in humans in vivo
    Eliana Lucchinetti
    Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, AB, Canada
    Anesth Analg 109:101-8. 2009
    The noble gas helium is devoid of anesthetic effects, and it elicits cardiac preconditioning...
  38. ncbi Comparison of nitrogen narcosis and helium pressure effects on striatal amino acids: a microdialysis study in rats
    Nicolas Vallee
    Faculte de Medecine Nord, IFR de Neurosciences Jean Roche, Université de la Méditerranée et Institut de Médecine Navale du Service de Santé des Armées, Physiologie et Physiopathologie en Conditions d Oxygénation Extrêmes, Marseille Cedex 20, France
    Neurochem Res 34:835-44. 2009
    ..was to study the effects of nitrogen at 3 MPa on striatal amino acid levels and to compare to those of 3 MPa of helium which is not narcotic at this pressure, by using a new technique of microdialysis samples extraction under ..
  39. ncbi Inhibition of glycogen synthase kinase or the apoptotic protein p53 lowers the threshold of helium cardioprotection in vivo: the role of mitochondrial permeability transition
    Paul S Pagel
    Clement J Zablocki Veterans Affairs Medical Center, Anesthesia Service, 5000 W National Ave, Milwaukee, WI 53295, USA
    Anesth Analg 107:769-75. 2008
    ..b>Helium produces cardioprotection by activating prosurvival kinases, but whether GSK and p53 inhibition mediate this ..
  40. ncbi The mechanism of helium-induced preconditioning: a direct role for nitric oxide in rabbits
    Paul S Pagel
    Department of Anesthesiology, Medical College of Wisconsin, Clement J Zablocki Veterans Affairs Medical Center, Anesthesia Service, 5000 W National Ave, Milwaukee, WI 53295, USA
    Anesth Analg 107:762-8. 2008
    b>Helium produces preconditioning against myocardial infarction by activating prosurvival signaling, but whether nitric oxide (NO) generated by endothelial NO synthase plays a role in this phenomenon is unknown...
  41. ncbi Reactive oxygen species and mitochondrial adenosine triphosphate-regulated potassium channels mediate helium-induced preconditioning against myocardial infarction in vivo
    Paul S Pagel
    Department of Anesthesiology, Medical College of Wisconsin and Clement J Zablocki Veterans Affairs Medical Center, Milwaukee, WI 53295, USA
    J Cardiothorac Vasc Anesth 22:554-9. 2008
    b>Helium produces preconditioning by activating prosurvival kinases, but the roles of reactive oxygen species (ROS) or mitochondrial adenosine triphosphate-regulated potassium (K(ATP)) channels in this process are unknown...
  42. ncbi Quantification of lung microstructure with hyperpolarized 3He diffusion MRI
    Dmitriy A Yablonskiy
    Mallinckrodt Inst of Radiology, 4525 Scott Ave, Rm 2302, St Louis, MO 63110, USA
    J Appl Physiol 107:1258-65. 2009
    ....
  43. ncbi Peritoneal and systemic pH during pneumoperitoneum with CO2 and helium in a pig model
    Maria Bergström
    Deptartment of Surgery, Sahlgrenska University Hospital Ostra, Goteborg University, Goteborg, Sweden
    Surg Endosc 22:359-64. 2008
    ..The most commonly used gas, CO(2), is known to be well tolerated, but also causes changes in acid-base balance. Helium is an alternative gas for laparoscopy. Although safe, it is not widely used...
  44. ncbi Argon-helium cryosurgery for treatment of C6 gliomas in rats and its effect on cellular immunity
    Ming Li
    Department of Neurosurgery, Institute of Neuroscience of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
    Technol Cancer Res Treat 9:87-94. 2010
    Argon-helium cryosurgery has shown encouraging therapeutic effects on some solid tumors, but its application in the treatment of gliomas remains poorly documented...
  45. ncbi The effects of helium-hyperoxia on 6-min walking distance in COPD: a randomized, controlled trial
    Darcy D Marciniuk
    Department of Medicine, University of Saskatchewan, SK, Canada
    Chest 131:1659-65. 2007
    We hypothesized that breathing helium-hyperoxia (HeO2) would significantly improve 6-min walking test (6MWT) distance in COPD subjects.
  46. ncbi The utility of albuterol nebulized with heliox during acute asthma exacerbations
    John P Kress
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Am J Respir Crit Care Med 165:1317-21. 2002
    ..This is likely due to the low-density gas improving albuterol deposition in the distal airways...
  47. ncbi Hypoxaemia induced by CO(2) or helium pneumoperitoneum is a co-factor in adhesion formation in rabbits
    C R Molinas
    Centre for Surgical Technologies, University Hospital Gasthuisberg, Leuven, Belgium
    Hum Reprod 15:1758-63. 2000
    ..Pure CO(2) or helium pneumoperitoneum was used for 10 (groups I and IV) or 45 min (groups II and V) to confirm the effect of duration ..
  48. ncbi Effect of combined recompression and air, oxygen, or heliox breathing on air bubbles in rat tissues
    O Hyldegaard
    The Institute of Medical Physiology, The Panum Institute, University of Copenhagen, 2200 N Copenhagen, Denmark
    J Appl Physiol 90:1639-47. 2001
    ..The clinical implication of these findings might be that heliox 50:50 is the mixture of choice for the treatment of decompression sickness...
  49. ncbi Assessment of the usefulness of helium-oxygen maximal expiratory flow curves in epidemiologic studies of lung disease in children
    S Redline
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115
    Am Rev Respir Dis 136:834-40. 1987
    ..at 50 and 25% of vital capacity (DD50 and DD25) (the ratios between maximal expiratory flow rates breathing helium-oxygen and air gas mixtures at each of these lung volumes), and the volume of isoflow (VisoV) (the lung volume, ..
  50. ncbi Helium and sulfur hexafluoride bolus washin in short-term microgravity
    B Dutrieue
    Biomedical Physics Laboratory, Universite Libre de Bruxelles, 1070 Brussels, Belgium
    J Appl Physiol 86:1594-602. 1999
    ..These results help explain previous studies in microG, which show large changes in gas mixing in vital capacity maneuvers but only small effects in tidal volume breaths...
  51. ncbi Contrast mechanisms and image formation in helium ion microscopy
    David C Bell
    School of Engineering and Applied Sciences and the Center for Nanoscale Systems, Harvard University, Cambridge, MA 02138, USA
    Microsc Microanal 15:147-53. 2009
    The helium ion microscope is a unique imaging instrument...
  52. ncbi Helium/oxygen mixture reduces the work of breathing at the end of the weaning process in patients with severe chronic obstructive pulmonary disease
    Jean-Luc Diehl
    , , France
    Crit Care Med 31:1415-20. 2003
    OBJECTIVE: To test the hypothesis that helium/oxygen mixture can reduce the work of breathing at the end of the weaning process in patients with chronic obstructive pulmonary disease. DESIGN: Prospective, randomized, crossover study...
  53. ncbi In vitro effects of helium-neon laser irradiation on human blood: blood viscosity and deformability of erythrocytes
    Xian-Qiang Mi
    Department of Physics, State Key Laboratory of Applied Surface Physics, Fudan University, Shanghai, China
    Photomed Laser Surg 22:477-82. 2004
    ..CONCLUSIONS: The positive effects of laser irradiation on improving the rheological properties of blood were demonstrated in vitro...
  54. ncbi MRI of helium-3 gas in healthy lungs: posture related variations of alveolar size
    Stanislao Fichele
    Academic Unit of Radiology, The University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    J Magn Reson Imaging 20:331-5. 2004
    ..To probe the variation of alveolar size in healthy lung tissue as a function of posture using diffusion-weighted helium-3 hyperpolarized gas imaging...
  55. ncbi Heliox improves gas exchange during high-frequency ventilation in a pediatric model of acute lung injury
    A Katz
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 164:260-4. 2001
    ..Compared with oxygen-enriched air, the 40% and 60% helium gas mixtures reduced Pa(CO(2)) by an average of 10.5 and 20.3 mm Hg, respectively...
  56. ncbi Helium-neon laser in viability of random skin flap in rats
    Carlos E Pinfildi
    Department of Plastic Surgery, Sao Paulo Federal University Unifesp EPM, Aracaju Street 1352, São Paulo 15801 0250, Brazil
    Lasers Surg Med 37:74-7. 2005
    The purpose of this study was to determine the role of helium-neon (He-Ne) laser random skin flap viability in rats.
  57. ncbi Effect of air and heliox as carrier gas on CO2 transport in a model of high-frequency oscillation comparing two oscillators
    Reinout J Mildner
    Department of Critical Care Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Crit Care Med 31:1759-63. 2003
    ..Using heliox as carrier gas significantly augmented CO(2) transport, but the increase is frequency and device dependent. The effect of heliox on oscillator performance and the clinical applicability of our findings require further study...
  58. ncbi 3D volume-localized pO2 measurement in the human lung with 3He MRI
    Jim M Wild
    Unit of Academic Radiology, University of Sheffield, UK
    Magn Reson Med 53:1055-64. 2005
    ..It is shown that the 2D thin-slice technique systematically underestimates pO2 when there is significant gas diffusion (factor of 4 underestimate for D = 0.9 cm(2)s(-1) representative of free (3)He in air)...
  59. ncbi Combined helium-3/proton magnetic resonance imaging measurement of ventilated lung volumes in smokers compared to never-smokers
    Neil Woodhouse
    Unit Academic of Radiology, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    J Magn Reson Imaging 21:365-9. 2005
    To use a combination of helium-3 (3-He) magnetic resonance imaging (MRI) and proton single-shot fast spin echo (SSFSE) to compare ventilated lung volumes in groups of "healthy" smokers, smokers diagnosed with moderate chronic ..
  60. ncbi Effects of helium-neon laser on levels of stress protein and arthritic histopathology in experimental osteoarthritis
    Yueh-Shuang Lin
    Kun Shan University of Technology, Kaohsiung, Taiwan
    Am J Phys Med Rehabil 83:758-65. 2004
    ..In the treated group, 21 rats received helium-neon laser treatment; in the control group, 21 rats received sham laser treatment...
  61. ncbi Feasibility of combining MR perfusion, angiography, and 3He ventilation imaging for evaluation of lung function in a porcine model
    Cheng Hong
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA
    Acad Radiol 12:202-9. 2005
    ..03). CONCLUSION: The combination of the three methods of MR perfusion, angiography, and 3H ventilation imaging may provide complementary information on abnormal lung anatomy and function...
  62. ncbi Functional analysis in single-lung transplant recipients: a comparative study of high-resolution CT, 3He-MRI, and pulmonary function tests
    Julia Zaporozhan
    Department of Radiology, Johannes Gutenberg University, Mainz, Germany
    Chest 125:173-81. 2004
    ..Lung volumes derived from pulmonary function test results served as clinical parameters and were used as the "gold standard."..
  63. ncbi Helium-oxygen in the postextubation period decreases inspiratory effort
    S Jaber
    , , AP-HP, , France
    Am J Respir Crit Care Med 164:633-7. 2001
    ..We tested whether breathing a helium-oxygen mixture (HeO(2)) would reduce inspiratory effort in the period after extubation...
  64. ncbi Heliox administration during high-frequency jet ventilation augments carbon dioxide clearance
    Vineet K Gupta
    Division of Pediatric Critical Care, Duke University Medical Center, Durham, NC, USA
    Respir Care 49:1038-44. 2004
    ..Improvements in gas exchange occurred rapidly. The combination of heliox and high frequency jet ventilation resulted in improved carbon dioxide clearance, respiratory stabilization, and the ability to wean ventilator settings...
  65. ncbi Comparison between 2D and 3D gradient-echo sequences for MRI of human lung ventilation with hyperpolarized 3He
    Jim M Wild
    Section of Academic Radiology, University of Sheffield, UK
    Magn Reson Med 52:673-8. 2004
    ..Theoretical simulations of the 2D and 3D k-space filters were also performed to predict the SNR and spatial resolution observed in the experimental images...
  66. ncbi Helium-neon and nitrogen laser irradiation accelerates the phagocytic activity of human monocytes
    Nanda Hemvani
    Department of Microbiology and Immunology, Choithram Hospital and Research Centre, Indore, India
    Photomed Laser Surg 23:571-4. 2005
    ..CONCLUSIONS: He-Ne and nitrogen laser irradiation activates the monocytes to increase intracellular killing of mycobacteria...
  67. ncbi Dose tolerance at helium and nitrogen temperatures for whole cell electron tomography
    Luis R Comolli
    Life Science Division, Lawrence Berkeley National Laboratory, CA, USA
    J Struct Biol 152:149-56. 2005
    ..here a comparison of the dose tolerance of Caulobacter crescentus cells embedded in amorphous ice at liquid helium versus liquid nitrogen temperature...
  68. ncbi The role of laser fluence in cell viability, proliferation, and membrane integrity of wounded human skin fibroblasts following helium-neon laser irradiation
    Denise H Hawkins
    Faculty of Health, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, South Africa
    Lasers Surg Med 38:74-83. 2006
    ..This study aimed to establish cellular responses to Helium-Neon (632.8 nm) laser irradiation using different laser fluences (0.5, 2...
  69. ncbi Helium-oxygen decreases inspiratory effort and work of breathing during pressure support in intubated patients with chronic obstructive pulmonary disease
    Didier Tassaux
    Medical Intensive Care, University Hospital, 1211, Geneva 14, Switzerland
    Intensive Care Med 31:1501-7. 2005
    OBJECTIVE: To evaluate the impact of helium-oxygen (He/O2) on inspiratory effort and work of breathing (WOB) in intubated COPD patients ventilated with pressure support...
  70. ncbi Analysis of intrapulmonary O(2) concentration by MR imaging of inhaled hyperpolarized helium-3
    B Eberle
    Department of Anesthesiology, Johannes Gutenberg University, D 55131 Mainz, Germany
    J Appl Physiol 87:2043-52. 1999
    ..The [O(2)] fractions in the regions of interest correlated closely with FET(O(2)) (R = 0.879; P < 0.0001). O(2)-sensitive (3)He-MRI may allow noninvasive study of regional distribution of ventilation and alveolar PO(2) in the lung...
  71. ncbi Emphysema: hyperpolarized helium 3 diffusion MR imaging of the lungs compared with spirometric indexes--initial experience
    Michael Salerno
    Center for In-vivo Hyperpolarized Gas MR Imaging, Department of Radiology, University of Virginia School of Medicine, 1000 Lee St, Box 800170, Charlottesville, VA 22908, USA
    Radiology 222:252-60. 2002
    PURPOSE: To quantitatively evaluate hyperpolarized helium 3 ((3)He) diffusion magnetic resonance (MR) images of the lung in patients with emphysema and to determine whether apparent diffusion coefficients (ADCs) measured with MR imaging ..
  72. ncbi Recent neurochemical basis of inert gas narcosis and pressure effects
    J C Rostain
    Université de la Méditerranée et IMNSSA, EA 3280, Physiopathologie et action thérapeutique des gaz sous pression, Faculte de Medecine Nord, IFR J Roche, 13916 Marseille 20, France
    Undersea Hyperb Med 33:197-204. 2006
    ..Compression with breathing mixtures where nitrogen is replaced by helium which has a low narcotic potency induces from 1 MPa, the high pressure nervous syndrome which is related to ..
  73. ncbi Helium-oxygen versus air-oxygen noninvasive pressure support in decompensated chronic obstructive disease: A prospective, multicenter study
    Philippe Jolliet
    Medical Intensive Care Division, University Hospital, Geneva, Switzerland
    Crit Care Med 31:878-84. 2003
    OBJECTIVE: To study whether noninvasive pressure support ventilation (NIPSV) with helium/oxygen (He/oxygen), which can reduce dyspnea, PaCO2, and work of breathing more than NIPSV with air/oxygen in decompensated chronic obstructive ..
  74. ncbi Signaling factors for irradiated glioma cells induced bystander responses in fibroblasts
    Chunlin Shao
    Institute of Radiation Medicine, Fudan University, No 2094 Xie Tu Road, Shanghai 200032, China
    Mutat Res 638:139-45. 2008
    ..a glioblastoma T98G population where a fraction of cells had been individually irradiated with a precise number of helium particles, additional micronucleus (MN) were induced in the non-irradiated human fibroblasts AG01522 cells and its ..
  75. ncbi Helium-neon laser irradiation stimulates migration and proliferation in melanocytes and induces repigmentation in segmental-type vitiligo
    Hsin Su Yu
    Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Invest Dermatol 120:56-64. 2003
    Low-energy helium-neon lasers (632.8 nm) have been employed in a variety of clinical treatments including vitiligo management...
  76. ncbi Measurement of pulmonary partial pressure of oxygen and oxygen depletion rate with hyperpolarized helium-3 MRI: a preliminary reproducibility study on pig model
    Jiangsheng Yu
    Department of Radiology, University of Pennsylvania, MMRRCC, B1 Stellar Chance Building, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Acad Radiol 15:702-12. 2008
    ..This work presents a preliminary reproducibility study on a pig model. In this study, important scan parameters, such as measurement timing and flip angle, are optimized to minimize the noise-induced measurement uncertainty...
  77. ncbi Indirect detection of lung perfusion using susceptibility-based hyperpolarized gas imaging
    Ivan E Dimitrov
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Magn Reson Imaging 21:149-55. 2005
    ..To address the problem of inadequate signal-to-noise ratio (SNR) encountered in lung perfusion magnetic resonance imaging (MRI) by developing an indirect detection based on the strong hyperpolarized (HP) gas signal...
  78. ncbi Functional MRI of the lung using hyperpolarized 3-helium gas
    Edwin J R van Beek
    Academic Unit of Radiology, University of Sheffield, Sheffield, UK
    J Magn Reson Imaging 20:540-54. 2004
    ..Four different techniques that have been used in various human investigations are discussed: ventilation distribution, ventilation dynamics, and small airway evaluation using diffusion imaging and oxygen uptake assessment...
  79. ncbi 3He MRI-based assessment of posture-dependent regional ventilation gradients in rats
    Sven Mansson
    Dept of Experimental Research, Malmö Univ Hospital, SE 205 02 Malmo, Sweden
    J Appl Physiol 98:2259-67. 2005
    ..01 +/- 0.02 cm(-1). It is concluded that the (3)He MRI-based method can detect and quantify regional ventilation gradients in animals as small as the rat and that these gradients depend on prone or supine posture of the animal...
  80. ncbi Single-acquisition sequence for the measurement of oxygen partial pressure by hyperpolarized gas MRI
    M C Fischer
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 52:766-73. 2004
    Magnetic resonance imaging (MRI) with hyperpolarized 3-helium gas (HP 3He) offers the possibility of studying functional lung parameters such as the alveolar oxygen concentration and oxygen depletion rate...
  81. ncbi Registered (1)H and (3)He magnetic resonance microscopy of the lung
    G A Johnson
    Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Magn Reson Med 45:365-70. 2001
    ..The total acquisition time was 21 min for the (3)He images and 64 min for the (1)H image. Airways down to the 6th and 7th orders are clearly visible. Magn Reson Med 45:365-370, 2001...
  82. ncbi Hyperpolarized gas MR imaging of the lung
    Talissa A Altes
    Department of Radiology, University of Virginia, Charlottesville, VA 22908, USA
    J Thorac Imaging 19:250-8. 2004
    ..It includes a description of the basic principles of hyperpolarized gas MRI and a review of the results of preliminary clinical investigations with this method...
  83. ncbi Assessment of a single-acquisition imaging sequence for oxygen-sensitive (3)He-MRI
    A J Deninger
    Department of Physics, Johannes Gutenberg University, Mainz, Germany
    Magn Reson Med 47:105-14. 2002
    MRI of the lungs using hyperpolarized helium-3 ((3)He) allows the determination of intrapulmonary oxygen partial pressures (p(O2))...
  84. ncbi Hyperpolarized helium-3 MR imaging of pulmonary function
    Masaru Ishii
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, 4940 Eastern Avenue, A5W 595A, Baltimore, MD 21224, USA
    Radiol Clin North Am 43:235-46. 2005
    ..Recent advances in HP MR imaging contrast agents have led to novel tests of pulmonary function. Many of these tests show promise in the clinical arena...
  85. ncbi Phase-contrast velocimetry with hyperpolarized 3He for in vitro and in vivo characterization of airflow
    Ludovic de Rochefort
    U2R2M, Unité de Recherche en Résonance Magnétique Médicale, UMR 8081, CNRS Universite Paris Sud, Le Kremlin Bicetre, France
    Magn Reson Med 55:1318-25. 2006
    ..Finally, in vivo feasibility was demonstrated in the human trachea during inhalation...
  86. ncbi Hyperpolarized noble gas MR imaging of the lung: potential clinical applications
    M Salerno
    Department of Radiology, University of Virginia Health Sciences System, Charlottesville, VA 22908, USA
    Eur J Radiol 40:33-44. 2001
    ..Hyperpolarized gas MRI has the potential to provide a comprehensive morphologic and functional assessment of the lung...
  87. ncbi Hyperpolarized 3helium magnetic resonance ventilation imaging of the lung in cystic fibrosis: comparison with high resolution CT and spirometry
    Colm J McMahon
    Department of Radiology, St Vincent s University Hospital, Dublin 4, Ireland
    Eur Radiol 16:2483-90. 2006
    ..01, respectively) than HRCT (R = +/-0.72 and +/-0.81, p < 0.05, respectively). This study showed that 3He MRI correlates strongly with structural HRCT abnormalities and is a stronger correlate of spirometry than HRCT in CF...
  88. ncbi Evaluation of asthma with hyperpolarized helium-3 MRI: correlation with clinical severity and spirometry
    Eduard E de Lange
    University of Virginia Health Sciences System, Department of Radiology, HSC 800170, Charlottesville, VA 22908, USA
    Chest 130:1055-62. 2006
    Accurate characterization of asthma severity is difficult due to the variability of symptoms. Hyperpolarized helium-3 MRI (H(3)HeMR) is a new technique in which the airspaces are visualized, depicting regions with airflow obstruction as &..
  89. ncbi [Dynamic imaging of the nasal cavity and the paranasal sinuses with polarized 3helium MRI]
    A Hanke
    , Langenbeckstrasse, Mainz, Germany
    Rofo 173:1126-30. 2001
    ..and visualization ventilation of the nasal cavity and paranasal sinus in MR by inhalation of hyperpolarized (3)helium. The goal was to evaluate ventilation defects of the paranasal sinuses...
  90. ncbi Assessment of lung disease in children with cystic fibrosis using hyperpolarized 3-Helium MRI: comparison with Shwachman score, Chrispin-Norman score and spirometry
    Edwin J R van Beek
    Unit of Academic Radiology, University of Sheffield, Sheffield, UK
    Eur Radiol 17:1018-24. 2007
    This study assesses the feasibility of hyperpolarized 3-Helium MRI in children with cystic fibrosis (CF) and correlates the findings with standard clinical parameters based on chest radiograph (CXR) and pulmonary function tests (PFT)...
  91. ncbi Magnetic susceptibility matching at the air-tissue interface in rat lung by using a superparamagnetic intravascular contrast agent: influence on transverse relaxation time of hyperpolarized helium-3
    Alexandre Vignaud
    U2R2M CNRS UMR8081, , CIERM, , , France
    Magn Reson Med 54:28-33. 2005
    Transverse relaxation of hyperpolarized helium-3 magnetization in respiratory airways highly depends on local magnetic field gradients induced by the magnetic susceptibility difference between gas and pulmonary tissue...
  92. ncbi MR imaging of mouse lung using hyperpolarized 3He: image acquisition and T1 estimation under spontaneous respiration
    Hirohiko Imai
    Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Japan
    Magn Reson Med Sci 5:57-64. 2006
    ..The purpose of this study was to acquire a hyperpolarized (HP) (3)He image of the mouse lung and to estimate 3He T1 in the lung from wash-out curve analysis under spontaneous respiration...
  93. ncbi [Functional imaging of the lung using a gaseous contrast agent: (3)helium-magnetic resonance imaging]
    K K Gast
    , , Mainz
    Rofo 177:660-9. 2005
    ..Magnetic resonance imaging of the lung has been advanced by the use of hyperpolarised (3)Helium as an inhaled gaseous contrast agent...
  94. ncbi Two-dimensional and three-dimensional oxygen mapping by 3He-MRI validation in a lung phantom
    Klaus Kurt Gast
    Department of Radiology, Johannes Gutenberg University Hospital, Langenbeckstrasse 1, 55131, Mainz, Germany
    Eur Radiol 15:1915-22. 2005
    ..Oxygen-sensitive 3He-MRI allows for noninvasive determination of the two- and three-dimensional distribution of oxygen partial pressure in gas-filled airspaces...
  95. ncbi 3He lung imaging in an open access, very-low-field human magnetic resonance imaging system
    R W Mair
    Harvard Smithsonian Center for Astrophysics, 60 Garden Street, MS 59, Cambridge, Massachusetts 02138, USA
    Magn Reson Med 53:745-9. 2005
    ..Experience with this prototype device will guide optimization of a second-generation very-low-field imager to enable studies of human pulmonary physiology as a function of subject orientation...
  96. ncbi Alveolar oxygen partial pressure and oxygen depletion rate mapping in rats using 3He ventilation imaging
    Katarzyna Cieslar
    Institute of Physics, Jagiellonian University, Krakow, Poland
    Magn Reson Med 57:423-30. 2007
    ..The oxygen depletion rates, ranging between 0.7 and 8.0 mbar s-1, are in close agreement with the published values for healthy rats...
  97. ncbi Hyperpolarized HHe 3 MRI of the lung in cystic fibrosis: assessment at baseline and after bronchodilator and airway clearance treatment
    Kimiknu Mentore
    Department of Radiology, University of Virginia Health System, Charlottesville, VA, USA
    Acad Radiol 12:1423-9. 2005
    RATIONALE AND OBJECTIVES: The purpose of this study is to determine hyperpolarized helium 3 (HHe) magnetic resonance (MR) findings of the lung in patients with cystic fibrosis (CF) compared with healthy subjects and determine whether HHe ..
  98. ncbi [A software tool for analysis and quantification of regional pulmonary ventilation using dynamic hyperpolarised-(3)He-MRI]
    F Lehmann
    , , Mainz
    Rofo 176:1399-408. 2004
    ..The clinical significance of the parameters, however, has to be determined in larger clinical studies. The software may become valuable in grading and following pulmonary function as well as in monitoring any therapy...
  99. ncbi Distribution of ventilation in lung transplant recipients: evaluation by dynamic 3He-MRI with lung motion correction
    Klaus Kurt Gast
    Department of Radiology, Klinikum Universitaet Mainz, Mainz, Germany
    Invest Radiol 38:341-8. 2003
    ..The ability of motion corrected dynamic 3He-magnetic resonance imaging (MRI) to discriminate distributional patterns of inhaled hyperpolarized 3He between different groups of lung transplant recipients was evaluated...
  100. ncbi Intrapulmonary 3He gas distribution depending on bolus size and temporal bolus placement
    Klaus Kurt Gast
    Klinik für Diagnostische und Interventionelle Radiologie der Johannes Gutenberg Universität Mainz, Mainz, Germany
    Invest Radiol 43:439-46. 2008
    ....
  101. ncbi Dynamic ventilation (3)He-magnetic resonance imaging with lung motion correction: gas flow distribution analysis
    Klaus Kurt Gast
    Department of Radiology, Klinikum Universitaet Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Invest Radiol 37:126-34. 2002
    ..Software was developed to correct for lung motion to improve the description of hyperpolarized (3)He gas distribution in the lung...

Research Grants75

  1. High-Tc susceptometer to monitor transfusional iron overload (NSR device)
    Gary M Brittenham; Fiscal Year: 2010
    ..Low-transition-temperature (low-Tc;operating at 4K, cooled by liquid helium) superconducting quantum interference device (SQUID) susceptometry was originally developed as a clinical method ..
  2. ELECTRON MICROSCOPIC STUDIES OF THE CRYSTALLINE LENS
    J Kuszak; Fiscal Year: 2002
    ..e spherical aberration) of the experimental animal lenses will be assessed by analysis with a low power helium-neon laser scan unit of our own design with particular reference to lens sutures...
  3. ADVANCED ELECTRON MICROSCOPIC STUDIES OF CRYSTALLINE LEN
    J Kuszak; Fiscal Year: 1999
    ..e spherical aberration) of the experimental animal lenses will be assessed by analysis with a low power helium-neon laser scan unit of our own design with particular reference to lens sutures...
  4. HE3 MR Diffusion & Low Dose CT Quantitation of Emphysema
    David Gierada; Fiscal Year: 2005
    The goal of this proposal is to develop and evaluate hyperpolarized helium-3 diffusion magnetic resonance imaging (He-3 dMRI) and low dose quantitative computed tomography (LD-QCT) indexes of emphysema as noninvasive biomarkers for the ..
  5. Respiratory Mechanics in Lung Disease and Surgery
    Stephen Loring; Fiscal Year: 2004
    ..2) To explore the differences between lung volumes measured by multiple breath helium dilution, plethysmography, and computed tomography (CT)...
  6. A Freeze-Fracture & Etching System for Northwestern Univ
    Mark Johnson; Fiscal Year: 2002
    ..In combination with the different methods of freeaing that will be available (a Med-Vac helium slam freezer and a Leica CPC Universal cryoworkstation), this will provide a versatile facility for ..
  7. Imaging regional physiologic parameters of lung function
    Rahim Rizi; Fiscal Year: 2009
    ..ventilation, perfusion, and ventilation-to-perfusion ratio, as well as oxygen depletion rate and diffusivity of helium-3 in the lung...
  8. Imaging regional physiologic parameters of lung function
    Rahim R Rizi; Fiscal Year: 2010
    ..ventilation, perfusion, and ventilation-to-perfusion ratio, as well as oxygen depletion rate and diffusivity of helium-3 in the lung...
  9. STRUCTURE AND DYNAMICS OF CONNEXIN26 GAP JUNCTIONS
    GINA SOSINSKY; Fiscal Year: 2007
    ..This involves improving specimen preparation, imaging at either liquid nitrogen or liquid helium temperature and implementation of a combined single particle/ 2D crystallographic approach to circumvent imperfect ..
  10. ELECTRON MICROSCOPIC STUDIES OF CRYSTALLINE LENSES
    J Kuszak; Fiscal Year: 1993
    ..2) A helium-neon laser scan device of the investigator's own design will be used to quantify the negative influence of lens ..
  11. VISION AND INTRARETINAL POTENTIALS
    DWIGHT BURKHARDT; Fiscal Year: 1993
    ..Special features include the use of a superfused slice preparation of the turtle eyecup and a helium-neon laser to generate intense adapting lights...
  12. A Compact Soft X-Ray Microbeam Facility for Small Laboratories
    STEPHEN HORNE; Fiscal Year: 2007
    ..source, the photon energy will be raised to the 1 KeV to 3 KeV range by exploiting optical transitions in helium-like systems such as neon 8+ and argon 16+...
  13. High Resolution Labels for EM
    James F Hainfeld; Fiscal Year: 2010
    ..Electron microscopes have recently advanced with the advent of cryoEM, large array CCDs, helium stages, energy filters, aberration correctors, tomography, and automation...
  14. High Tc susceptometer for magnetic measure of body iron
    Gary Brittenham; Fiscal Year: 2005
    ..Recent technological advances make possible replacement of each of these low-Tc elements, cooled by liquid helium, with components able to function when cooled by liquid nitrogen...
  15. DYNAMICS OF ALVEOLAR RECRUITMENT IN LUNG INJURY
    Robert Harris; Fiscal Year: 2005
    ..assessed by distributions of opening or closing pressures from the PV curve, NO uptake kinetics, oxygenation, and helium dilution lung volume...
  16. REDUCED INFLAMMATORY RESPONSE DURING LAPAROSCOPY
    Mark Talamini; Fiscal Year: 2005
    ..The effect of pneumoperitoneum with CO2, helium, or air on the inflammatory response after sepsis (cecal ligation and puncture) will be compared...
  17. High-speed cell sorter
    Ronald Veazey; Fiscal Year: 2002
    ..this application is to obtain a Becton Dickinson FACS Vantage SE flow cytometer equipped with an Enterprise II and Helium/Neon laser, and the high speed Turbosort option, for use by Researchers at, and in proximity to, the Tulane ..
  18. Hermetic Nanowire Interconnects for Neural Prostheses
    James Weiland; Fiscal Year: 2007
    ..In addition to these two activities, initial system test and biocompatibility assessments will be performed. Helium leak testing will be used to assess hermeticity...
  19. STUDIES OF CELL JUNCTIONS & CELL MEMBRANES IN THE LENS
    Woo kuen Lo; Fiscal Year: 1993
    ..electron microscopy using the improved fixation method developed in this laboratory; (2) rapid-freezing in liquid helium temperature without prior chemical fixation, and in conjunction with free-substitution, freeze-fracture and deep-..
  20. Dynamic 3HE MRI of the Lungs
    VINAY PAI; Fiscal Year: 2007
    ..Many causes of airway dysfunction, such as asthma, may be occult to CT. MRI of helium-3 (3HeMRI) is a recently developed method of visualizing lung air spaces and airways...
  21. LASER SCANNING CONFOCAL MICROSCOPE
    Robert Lechleider; Fiscal Year: 2003
    ..The three lasers requested, argon, red Helium-Neon and green Helium-Neon, will provide excitatory signals for most applications, with the expansion with ..