lanthanoid series elements

Summary

Summary: Elements of the lanthanoid series including atomic number 57 (LATHANUM) through atomic number 71 (LUTETIUM).

Top Publications

  1. ncbi Synthesis, characterization, and application of Eu(III), Tb(III), Sm(III), and Dy(III) lanthanide chelate nanoparticle labels
    Petri Huhtinen
    Department of Biotechnology, University of Turku, Tykistokatu 6, FIN 20520 Turku, Finland
    Anal Chem 77:2643-8. 2005
  2. pmc Comparison of dissociation-enhanced lanthanide fluorescent immunoassays to enzyme-linked immunosorbent assays for detection of staphylococcal enterotoxin B, Yersinia pestis-specific F1 antigen, and Venezuelan equine encephalitis virus
    D R Smith
    Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA
    Clin Diagn Lab Immunol 8:1070-5. 2001
  3. ncbi Protein alignment by a coexpressed lanthanide-binding tag for the measurement of residual dipolar couplings
    Jens Wöhnert
    Institut für Organische Chemie und Chemische Biologie, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe Universitat Frankfurt, Marie Curie Strasse 11, 60439 Frankfurt M, Germany
    J Am Chem Soc 125:13338-9. 2003
  4. ncbi NMR structure determination of protein-ligand complexes by lanthanide labeling
    Guido Pintacuda
    Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia
    Acc Chem Res 40:206-12. 2007
  5. ncbi Upconversion multicolor fine-tuning: visible to near-infrared emission from lanthanide-doped NaYF4 nanoparticles
    Feng Wang
    Department of Chemistry, National University of Singapore, Singapore 117543
    J Am Chem Soc 130:5642-3. 2008
  6. doi Time-resolved luminescence microscopy of bimetallic lanthanide helicates in living cells
    Bo Song
    Laboratory of Lanthanide Supramolecular Chemistry, Ecole Polytechnique Federale de Lausanne, BCH 1404, 1015 Lausanne, Switzerland
    Org Biomol Chem 6:4125-33. 2008
  7. doi A four-color colloidal multiplexing nanoparticle system
    Oliver Ehlert
    Freiburg Materials Research Center, University of Freiburg, Germany
    ACS Nano 2:120-4. 2008
  8. doi Multiplexed determination of protein biomarkers using metal-tagged antibodies and size exclusion chromatography--inductively coupled plasma mass spectrometry
    Mattia Terenghi
    Dipartimento di Chimica Generale ed Inorganica, Chimica Analitica, Chimica Fisica, Universita degli Studi di Parma, Viale G P Usberti 17 a, I 43100 Parma, Italy
    Anal Chem 81:9440-8. 2009
  9. doi Lanthanide luminescence for functional materials and bio-sciences
    Svetlana V Eliseeva
    Laboratory of Lanthanide Supramolecular Chemistry, Swiss Federal Institute of Technology, Lausanne EPFL
    Chem Soc Rev 39:189-227. 2010
  10. ncbi Simultaneous use of time-resolved fluorescence and anti-stokes photoluminescence in a bioaffinity assay
    Katri Kuningas
    Department of Biotechnology, University of Turku, Tykistokatu 6A, FIN 20520 Turku, Finland
    Anal Chem 77:2826-34. 2005

Research Grants

  1. Flourescent Ceramic Nanoprobes (RMI)
    TIMOTHY BOYLE; Fiscal Year: 2008
  2. Flourescent Ceramic Nanoprobes (RMI)
    TIMOTHY BOYLE; Fiscal Year: 2007
  3. Microarrays for DNA binding proteins
    Tomasz Heyduk; Fiscal Year: 2006
  4. INTER & INTRAMOLECULAR COMMUNICATIONS IN TRANSCRIPTION
    Tomasz Heyduk; Fiscal Year: 2006
  5. STRUCTURAL AND MECHANISTIC STUDIES OF PHOSPHONATASE
    Karen Allen; Fiscal Year: 2005
  6. MOLECULAR BEACONS FOR PROTEIN DETECTION
    Tomasz Heyduk; Fiscal Year: 2005
  7. INTER AND INTRAMOLECULAR COMMUNICATIONS IN TRANSCRIPTION
    Tomasz Heyduk; Fiscal Year: 2010
  8. FACTORS STABILIZING RNA STRUCTURES
    David Draper; Fiscal Year: 2005
  9. Coupling Reactions-Methods Development and Applications
    GARY MOLANDER; Fiscal Year: 2005
  10. INTER & INTRAMOLECULAR COMMUNICATIONS IN TRANSCRIPTION
    Tomasz Heyduk; Fiscal Year: 2005

Detail Information

Publications197 found, 100 shown here

  1. ncbi Synthesis, characterization, and application of Eu(III), Tb(III), Sm(III), and Dy(III) lanthanide chelate nanoparticle labels
    Petri Huhtinen
    Department of Biotechnology, University of Turku, Tykistokatu 6, FIN 20520 Turku, Finland
    Anal Chem 77:2643-8. 2005
    ..The spectral and functional properties of the lanthanide-embedded polystyrene nanoparticles developed here suggest that the technology is applicable for high-sensitivity multicolor assays...
  2. pmc Comparison of dissociation-enhanced lanthanide fluorescent immunoassays to enzyme-linked immunosorbent assays for detection of staphylococcal enterotoxin B, Yersinia pestis-specific F1 antigen, and Venezuelan equine encephalitis virus
    D R Smith
    Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA
    Clin Diagn Lab Immunol 8:1070-5. 2001
    ....
  3. ncbi Protein alignment by a coexpressed lanthanide-binding tag for the measurement of residual dipolar couplings
    Jens Wöhnert
    Institut für Organische Chemie und Chemische Biologie, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe Universitat Frankfurt, Marie Curie Strasse 11, 60439 Frankfurt M, Germany
    J Am Chem Soc 125:13338-9. 2003
    ..6 to 6.1 Hz for Dy3+, while an opposite alignment tensor is observed for Tm3+ (4.5 to -2.9 Hz) at 800 MHz. Experimental RDCs are in excellent agreement with those predicted on the basis of the X-ray structure of the protein...
  4. ncbi NMR structure determination of protein-ligand complexes by lanthanide labeling
    Guido Pintacuda
    Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia
    Acc Chem Res 40:206-12. 2007
    ..Strategies for site-specific incorporation of lanthanide ions into proteins are summarized...
  5. ncbi Upconversion multicolor fine-tuning: visible to near-infrared emission from lanthanide-doped NaYF4 nanoparticles
    Feng Wang
    Department of Chemistry, National University of Singapore, Singapore 117543
    J Am Chem Soc 130:5642-3. 2008
    ..The approach allows access to a wide range of luminescence emission from visible to near-infrared by single-wavelength excitation...
  6. doi Time-resolved luminescence microscopy of bimetallic lanthanide helicates in living cells
    Bo Song
    Laboratory of Lanthanide Supramolecular Chemistry, Ecole Polytechnique Federale de Lausanne, BCH 1404, 1015 Lausanne, Switzerland
    Org Biomol Chem 6:4125-33. 2008
    ..43 ms], compared to >10 microM when using conventional luminescence microscopy. Furthermore, multiplex labeling could be achieved with the Tb(III) [Q = 0.11, tau = 0.65 ms], and Sm(III) [Q = 0.0038, tau = 0.030 ms] analogues...
  7. doi A four-color colloidal multiplexing nanoparticle system
    Oliver Ehlert
    Freiburg Materials Research Center, University of Freiburg, Germany
    ACS Nano 2:120-4. 2008
    ..The particles were phase transferred into polar solvents by means of silica encapsulation and were characterized by transmission electron microscopy, X-ray diffraction, and photoluminescence spectroscopy...
  8. doi Multiplexed determination of protein biomarkers using metal-tagged antibodies and size exclusion chromatography--inductively coupled plasma mass spectrometry
    Mattia Terenghi
    Dipartimento di Chimica Generale ed Inorganica, Chimica Analitica, Chimica Fisica, Universita degli Studi di Parma, Viale G P Usberti 17 a, I 43100 Parma, Italy
    Anal Chem 81:9440-8. 2009
    ..3 times lower than an ELISA test. The method was validated for the analysis of the proteins in human serum and proved to be able to discriminate ovary and uterus tumor tissue samples from those of healthy subjects...
  9. doi Lanthanide luminescence for functional materials and bio-sciences
    Svetlana V Eliseeva
    Laboratory of Lanthanide Supramolecular Chemistry, Swiss Federal Institute of Technology, Lausanne EPFL
    Chem Soc Rev 39:189-227. 2010
    ....
  10. ncbi Simultaneous use of time-resolved fluorescence and anti-stokes photoluminescence in a bioaffinity assay
    Katri Kuningas
    Department of Biotechnology, University of Turku, Tykistokatu 6A, FIN 20520 Turku, Finland
    Anal Chem 77:2826-34. 2005
    ..In this study we show that up-converting anti-Stokes photoluminescent phosphors could be employed in bioaffinity assays as very potential labels with significant advantages either alone or together with long-lifetime lanthanide chelates...
  11. pmc Helical lanthanide(III) complexes with chiral nonaaza macrocycle
    Janusz Gregoliński
    Department of Chemistry, University of Wrocław, 14 F Joliot Curie, 50 383 Wrocław, Poland
    J Am Chem Soc 130:17761-73. 2008
    ....
  12. pmc An NMR strategy for fragment-based ligand screening utilizing a paramagnetic lanthanide probe
    Tomohide Saio
    Department of Structural Biology, Faculty of Advanced Life Science, Hokkaido University, N 21, W 11, Sapporo 001 0021, Japan
    J Biomol NMR 51:395-408. 2011
    ..The usefulness of this strategy was demonstrated in the case of the growth factor receptor-bound protein 2 (Grb2) Src homology 2 (SH2) domain and its low- and high-affinity ligands...
  13. ncbi Hybrid lanthanide nanoparticles with paramagnetic shell coated on upconversion fluorescent nanocrystals
    Zhengquan Li
    Division of Bioengineering, Faculty of Engineering, Yong Loo Lin School of Medicine, National University of Singapore, 7 Engineering Drive 1, Singapore 117574
    Langmuir 25:12015-8. 2009
    ....
  14. doi Time-gated luminescence microscopy allowing direct visual inspection of lanthanide-stained microorganisms in background-free condition
    Dayong Jin
    Advanced Cytometry Laboratories at Macquarie, MQ Biofocus Research Centre, Faculty of Science, Macquarie University, NSW 2109 Australia
    Anal Chem 83:2294-300. 2011
    ..The availability of low-cost, robust time-gated microscopes will aid development of long-lifetime luminescence bioprobes and accelerate their application in routine laboratory diagnostics...
  15. doi Multicolor output and shape controlled synthesis of lanthanide-ion doped fluorides upconversion nanoparticles
    Wenbin Niu
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116012, China
    Dalton Trans 40:3305-14. 2011
    ....
  16. doi Engineering of a bis-chelator motif into a protein α-helix for rigid lanthanide binding and paramagnetic NMR spectroscopy
    James D Swarbrick
    Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Parkville, VIC 3052
    Chem Commun (Camb) 47:7368-70. 2011
    ....
  17. doi DOTA-amide lanthanide tag for reliable generation of pseudocontact shifts in protein NMR spectra
    Bim Graham
    Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Parkville, VIC 3052, Australia
    Bioconjug Chem 22:2118-25. 2011
    ..The performance of the tag is demonstrated with the N-terminal domain of the E. coli arginine repressor and the A28C mutant of human ubiquitin...
  18. ncbi Long-range-distance NMR effects in a protein labeled with a lanthanide-DOTA chelate
    Monica D Vlasie
    Leiden Institute of Chemistry, Gorlaeus Laboratories Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    Chemistry 13:1715-23. 2007
    ..This study demonstrates that bidentate attachment of a paramagnetic probe enables determination of long-range distances...
  19. ncbi Time-resolved long-lived luminescence imaging method employing luminescent lanthanide probes with a new microscopy system
    Kenjiro Hanaoka
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Am Chem Soc 129:13502-9. 2007
    ..This new imaging technique should facilitate investigations of biological functions with fluorescence microscopy, complementing other fluorescence imaging methodologies...
  20. ncbi Lanthanide labeling offers fast NMR approach to 3D structure determinations of protein-protein complexes
    Guido Pintacuda
    Research School of Chemistry, Australian National University, Canberra ACT 0200, Australia
    J Am Chem Soc 128:3696-702. 2006
    ..Degeneracies in the mutual orientation of the protein structures were resolved by the use of two different lanthanide ions, Dy3+ and Er3+...
  21. ncbi Convenient synthesis of multifunctional EDTA-based chiral metal chelates substituted with an S-mesylcysteine
    Andrei Leonov
    Max Planck Institute for Biophysical Chemistry, Department of NMR Based Structural Biology, Am Fassberg 11, 37077 Gottingen, Germany
    Chemistry 11:3342-8. 2005
    ....
  22. doi Paramagnetic labelling of proteins and oligonucleotides for NMR
    Xun Cheng Su
    The Australian National University, Canberra, Australia
    J Biomol NMR 46:101-12. 2010
    ..The paramagnetic tags include nitroxide radicals and metal chelators. Particular emphasis is placed on tags suitable for site-specific and rigid attachment of lanthanide ions to macromolecules...
  23. pmc Engineering encodable lanthanide-binding tags into loop regions of proteins
    Katja Barthelmes
    Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe University of Frankfurt, Max von Laue Strasse 7, 60438 Frankfurt, Germany
    J Am Chem Soc 133:808-19. 2011
    ..The current data provide support that encodable LBTs serve as versatile biophysical tags when inserted into loop regions of proteins of known structure or predicted via homology modeling...
  24. doi Lanthanide-binding peptides for NMR measurements of residual dipolar couplings and paramagnetic effects from multiple angles
    Xun Cheng Su
    Research School of Chemistry, Australian National University, Canberra ACT 0200, Australia
    J Am Chem Soc 130:1681-7. 2008
    ....
  25. doi Highly sensitive protein detection based on lanthanide chelates with antenna ligands providing a linear range of five orders of magnitude
    Thole Zuchner
    Institute of Bioanalytical Chemistry, Center of Biotechnology and Biomedicine, Faculty of Chemistry and Mineralogy, Leipzig University, Deutscher Platz 5, 04103 Leipzig, Germany
    Anal Chem 81:9449-53. 2009
    ..In addition, the new compound offers multiplexing capabilities...
  26. pmc Optimization of time-resolved fluorescence assay for detection of europium-tetraazacyclododecyltetraacetic acid-labeled ligand-receptor interactions
    Channa R De Silva
    Department of Chemistry, University of Arizona, Tucson, AZ 85721, USA
    Anal Biochem 398:15-23. 2010
    ..The modified assay provides superior results and is appropriate for high-throughput screening of ligand libraries...
  27. ncbi Structural origin of the high affinity of a chemically evolved lanthanide-binding peptide
    Mark Nitz
    Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Angew Chem Int Ed Engl 43:3682-5. 2004
  28. ncbi Prospects for lanthanides in structural biology by NMR
    Gottfried Otting
    Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia
    J Biomol NMR 42:1-9. 2008
    ..Cell-free protein synthesis is positioned to play an important role in this strategy, as an inexpensive source of selectively labelled protein samples and for easy site-specific incorporation of unnatural lanthanide-binding amino acids...
  29. ncbi DOTA-M8: An extremely rigid, high-affinity lanthanide chelating tag for PCS NMR spectroscopy
    Daniel Haussinger
    Department of Chemistry, University of Basel, St Johanns Ring 19, 4056 Basel, Switzerland
    J Am Chem Soc 131:14761-7. 2009
    ....
  30. ncbi Tuning the affinity for lanthanides of calcium binding proteins
    Ivano Bertini
    Magnetic Resonance Center and Department of Chemistry, University of Florence, Sesto Fiorentino, Italy
    Biochemistry 42:8011-21. 2003
    ..Finally, by using CaM samples containing only three of the four calcium ions, it was possible to prepare well-defined Ca(3)Ln-CaM derivatives (Ln = Tb, Dy, Tm, and Yb), with interesting properties as NMR probes...
  31. pmc PCS-based structure determination of protein-protein complexes
    Tomohide Saio
    Graduate School of Life Science, Hokkaido University, Sapporo, 001 0021, Japan
    J Biomol NMR 46:271-80. 2010
    ....
  32. ncbi Principles and biophysical applications of lanthanide-based probes
    Paul R Selvin
    Physics Department and Biophysics Group, University of Illinois, Urbana, IL 61801, USA
    Annu Rev Biophys Biomol Struct 31:275-302. 2002
    ....
  33. ncbi Structure determination of protein-ligand complexes by transferred paramagnetic shifts
    Michael John
    Australian National University, Research School of Chemistry, Canberra, ACT 0200, Australia
    J Am Chem Soc 128:12910-6. 2006
    ..The binding mode of thymidine was found to be very similar to that of thymidine monophosphate present in the crystal structure...
  34. ncbi Progress in lanthanides as luminescent probes
    I Hemmilä
    Perkin Elmer Life and Analytical Sciences, Wallac Oy, P O Box 10, Fin 20101, Turku, Finland
    J Fluoresc 15:529-42. 2005
    ..This review gives a short overview of recent development of lanthanide chelate-labels and discusses in more details of energy levels and their exploitation in new assay formats...
  35. ncbi Sequence-specific and stereospecific assignment of methyl groups using paramagnetic lanthanides
    Michael John
    Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia
    J Am Chem Soc 129:13749-57. 2007
    ..The approaches are demonstrated with the complex between the N-terminal domain of the subunit epsilon and the subunit theta of the Escherichia coli DNA polymerase III...
  36. ncbi Synthesis of colloidal upconverting NaYF4 nanocrystals doped with Er3+, Yb3+ and Tm3+, Yb3+ via thermal decomposition of lanthanide trifluoroacetate precursors
    John Christopher Boyer
    Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke Street West, Montreal, QC H4B 1R6, Canada
    J Am Chem Soc 128:7444-5. 2006
    ....
  37. ncbi Design, synthesis, and evaluation of a lanthanide chelating protein probe: CLaNP-5 yields predictable paramagnetic effects independent of environment
    Peter H J Keizers
    Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, Post Office Box 9502, 2300 RA Leiden, The Netherlands
    J Am Chem Soc 130:14802-12. 2008
    ..These findings designate CLaNP-5 as a protein probe to deliver unambiguous high quality structural restraints in studies on protein-protein and protein-ligand interactions...
  38. pmc From antenna to assay: lessons learned in lanthanide luminescence
    Evan G Moore
    Department of Chemistry, University of California, Berkeley, and Chemical Sciences Division, Lawrence Berkeley National Laboratories, Berkeley, California 94720, USA
    Acc Chem Res 42:542-52. 2009
    ..Lastly, we describe a Tb(III)-IAM compound--now carried through to commercial availability--that offers improved performance in the common HTRF platform and has the potential to vastly improve sensitivity...
  39. ncbi Increased paramagnetic effect of a lanthanide protein probe by two-point attachment
    Peter H J Keizers
    Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    J Am Chem Soc 129:9292-3. 2007
  40. doi Two-point anchoring of a lanthanide-binding peptide to a target protein enhances the paramagnetic anisotropic effect
    Tomohide Saio
    Graduate School of Life Science, Hokkaido University, Sapporo, 001 0021, Japan
    J Biomol NMR 44:157-66. 2009
    ..Though there is slight residual mobility of the lanthanide-binding tag, the present tag provides a higher anisotropic paramagnetic effect...
  41. ncbi Double-lanthanide-binding tags: design, photophysical properties, and NMR applications
    Langdon J Martin
    Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 129:7106-13. 2007
    ..Together, these results indicate that dLBTs will be valuable chemical tools for biophysical applications leading to new approaches for studying the structure, function, and dynamics of proteins...
  42. ncbi Two new chiral EDTA-based metal chelates for weak alignment of proteins in solution
    Peter Haberz
    Max Planck Institute for Biophysical Chemistry, Department of NMR Based Structural Biology, Am Fassberg 11, 37077 Gottingen, Germany
    Org Lett 8:1275-8. 2006
    ..Alignment tensors for the new tags are linearly independent compared to those of previously published tags...
  43. doi Intermolecular dynamics studied by paramagnetic tagging
    Xingfu Xu
    Institute of Chemistry, Leiden University, P O Box 9502, 2300 RA, Leiden, The Netherlands
    J Biomol NMR 43:247-54. 2009
    ..The applied method provides a simple and straightforward way to observe dynamics in protein complexes or domain-domain mobility without the need for external alignment media...
  44. ncbi A dipicolinic acid tag for rigid lanthanide tagging of proteins and paramagnetic NMR spectroscopy
    Xun Cheng Su
    Research School of Chemistry, Australian National University, Canberra ACT 0200, Australia
    J Am Chem Soc 130:10486-7. 2008
    ..The close proximity of the lanthanide ion promotes accurate determinations of magnetic susceptibility anisotropy tensors. In addition, the small size of the tag makes it highly suitable for studies of intermolecular interactions...
  45. ncbi Novel techniques for weak alignment of proteins in solution using chemical tags coordinating lanthanide ions
    Takahisa Ikegami
    Max Planck Institute for Biophysical Chemistry, Department of NMR Based Structural Biology, University of Frankfurt am Fassberg 11, D 37077 Gottingen, Germany
    J Biomol NMR 29:339-49. 2004
    ..We observed residual (15)N,(1)H-dipolar couplings of up to 8 Hz at 800 MHz induced by a single alignment tensor from this tag...
  46. ncbi Site-specific labelling of proteins with a rigid lanthanide-binding tag
    Xun Cheng Su
    Research School of Chemistry, Australian National University Canberra, ACT 0200, Australia
    Chembiochem 7:1599-604. 2006
    ....
  47. ncbi A caged lanthanide complex as a paramagnetic shift agent for protein NMR
    Miguel Prudêncio
    Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    Chemistry 10:3252-60. 2004
    ..The molecule exists in several isomeric forms with different paramagnetic tensors; this provides a fast way to obtain long-range distance restraints...
  48. ncbi Paramagnetically induced residual dipolar couplings for solution structure determination of lanthanide binding proteins
    Renato Barbieri
    Magnetic Resonance Center and Department of Chemistry, University of Florence, Via Luigi Sacconi 6, 50019, Sesto Fiorentino, Italy
    J Am Chem Soc 124:5581-7. 2002
    ..The effect of mobility is also assessed. In principle, information on the mobility can be obtained with a number of lanthanide ions >5, or by combining a smaller number of lanthanide ions with a few orienting devices...
  49. ncbi Paramagnetism-based NMR restraints provide maximum allowed probabilities for the different conformations of partially independent protein domains
    Ivano Bertini
    Magnetic Resonance Center CERM, University of Florence, Via Luigi Sacconi 6, 50019, Sesto Fiorentino, Italy
    J Am Chem Soc 129:12786-94. 2007
    ..Such variety is somewhat reduced in the calmodulin-alpha-synuclein adduct, which however still retains high flexibility. The flexibility of the calmodulin-alpha-synuclein adduct is an unexpected result of this research...
  50. ncbi Lanthanide complexes in molecular recognition and chirality sensing of biological substrates
    Hiroshi Tsukube
    Department of Chemistry, Graduate School of Science, Osaka City University, Sugimoto, Sumiyoshi ku, Osaka 558 8585, Japan
    Chem Rev 102:2389-403. 2002
  51. doi Accurate solution structures of proteins from X-ray data and a minimal set of NMR data: calmodulin-peptide complexes as examples
    Ivano Bertini
    Magnetic Resonance Center CERM, University of Florence, Via Luigi Sacconi 6, 50019 Sesto Fiorentino, Italy
    J Am Chem Soc 131:5134-44. 2009
    ....
  52. ncbi A dodecalanthanide wheel supported by p-tert-butylsulfonylcalix[4]arene
    Takashi Kajiwara
    Department of Chemistry, Graduate School of Science, Tohoku University and CREST JST, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Chem Asian J 1:349-51. 2006
    ..The longest and shortest diameters of the core were estimated to be 17.7562(16) and 13.6810(13) A, respectively, and the saddle-shaped molecule possesses a pocketlike cavity inside...
  53. ncbi Photophysical properties of novel ternary lanthanide complexes with long chain mono-L cis-butene dicarboxylate (L = hexadecyl, octadecyl and eicosyl) and 2,2'-bipyridyl (or 1,10-phenanthroline)
    Bing Yan
    Department of Chemistry, Tongji University, Siping Road 1239, Shanghai 200092, China
    J Fluoresc 17:331-7. 2007
    ....
  54. ncbi Synthesis, infrared and fluorescence spectra of lanthanide complexes with a new amide-based 1,3,4-oxadiazole derivative
    Xiao Liang Tang
    Department of Chemistry and State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
    Spectrochim Acta A Mol Biomol Spectrosc 68:349-53. 2007
    ..Under the excitation of UV light, these complexes exhibit characteristic fluorescence of europium and terbium ions. The solvent factors influencing the fluorescent intensity were discussed...
  55. pmc A bridge to coordination isomer selection in lanthanide(III) DOTA-tetraamide complexes
    Jeff Vipond
    Department of Chemistry, University of Texas at Dallas, P O Box 830660, Richardson, Texas 75083 0688, USA
    Inorg Chem 46:2584-95. 2007
    ....
  56. ncbi Synthesis and luminescent properties of the lanthanide isothiocyanate complexes with an amide-type tripodal ligand
    Kuan Zhen Tang
    State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China
    Spectrochim Acta A Mol Biomol Spectrosc 67:858-63. 2007
    ..At the same time, the luminescent properties of the Sm(III), Eu(III), Tb(III), Dy(III) isothiocyanate complexes in solid state and the Tb(III) complex in solvents were also investigated...
  57. ncbi Facile construction of lanthanide metallomacrocycles with the bridging imidazolate and triazolate ligands and their ring expansions
    Jie Zhang
    Department of Chemistry, Fudan University, Shanghai 200433, People s Republic of China zhangjie fudan edu cn
    Inorg Chem 46:321-7. 2007
    ..All of these new complexes have been characterized by elemental analysis and spectroscopic properties, and their structures have also been determined through X-ray single-crystal diffraction analysis...
  58. ncbi Stepwise synthesis and magnetic control of trimetallic magnets [Co2Ln(L)2(H2O)4][Cr(CN)6].nH2O (Ln = La, Gd; H2L = 2,6-Di(acetoacetyl)pyridine) with 3-D pillared-layer structure
    Takuya Shiga
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo ku, Kyoto 615 8510, Japan
    J Am Chem Soc 128:16426-7. 2006
    ..The overall magnetic nature can be systematically controlled by Ln(III) ions inserted between the 2-D ferromagnetic layers...
  59. ncbi Rational tuning of melting entropies for designing luminescent lanthanide-containing thermotropic liquid crystals at room temperature
    Aude Escande
    Department of Inorganic, Analytical and Applied Chemistry, University of Geneva, 30 quai E Ansermet, 1211 Geneva 4, Switzerland
    Chemistry 13:8696-713. 2007
    ..Extension of the concept of chemical tuning of melting entropies for the global design of room-temperature metallomesogens and liquid crystals is discussed...
  60. ncbi From spherical to osmotically shrunken paramagnetic liposomes: an improved generation of LIPOCEST MRI agents with highly shifted water protons
    Enzo Terreno
    Dipartimento di Chimica I F M and Centro di Imaging Molecolare, Universita di Torino, Via P Giuria 7, 10125 Torino, Italy
    Angew Chem Int Ed Engl 46:966-8. 2007
  61. pmc Brilliant Sm, Eu, Tb, and Dy chiral lanthanide complexes with strong circularly polarized luminescence
    STEPHANE PETOUD
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    J Am Chem Soc 129:77-83. 2007
    ..The combination of high luminescence intensity with CPL activity should enable new bioanalytical applications of macromolecules in chiral environments...
  62. ncbi A novel strategy for the design of 8-hydroxyquinolinate-based lanthanide bioprobes that emit in the near infrared range
    Steve Comby
    Laboratory of Lanthanide Supramolecular Chemistry, Ecole Polytechnique Federale de Lausanne EPFL, BCH 1402, 1015 Lausanne, Switzerland
    Chemistry 13:936-44. 2007
    ..Finally, the same podate is shown to couple to human serum albumin, leading to an increase of 50 % in the NIR-luminescence intensity...
  63. doi Advances in structurally characterized lanthanide alkoxide, aryloxide, and silyloxide compounds
    Timothy J Boyle
    Sandia National Laboratories, Advanced Materials Laboratory, 1001 University Boulevard, S E, Albuquerque, New Mexico 87106, USA
    Chem Rev 108:1896-917. 2008
  64. doi New 9- or 10-dentate luminescent lanthanide chelates
    Pinghua Ge
    Department of Physics and Center for Biophysics and Computational Biology, University of Illinois, Urbana, Illinois 61801, USA
    Bioconjug Chem 19:1105-11. 2008
    ..The TTHA-based chelate provides moderately good protection to the lanthanide ions...
  65. doi Synthesis of amidolanthanides with new chiral biaryl-based NNO ligands and their use as catalysts for enantioselective hydroamination/cyclization
    Qiuwen Wang
    Department of Chemistry, Beijing Normal University, Beijing 100875, China
    Inorg Chem 47:4319-28. 2008
    ..Complexes 6- 9 are active catalysts for the asymmetric hydroamination/cyclization of aminoalkenes, affording cyclic amines in good yields with moderate ee values...
  66. doi Molecular switching in the near infrared (NIR) to visible/NIR f-f emission with a functional-lanthanide complexes
    Ga Lai Law
    Department of Chemistry, The University of Hong Kong, Hong Kong, S A R, People s Republic of China
    J Fluoresc 18:749-52. 2008
    ....
  67. doi A lanthanide phosphinidene complex: synthesis, structure, and phospha-Wittig reactivity
    Jason D Masuda
    Los Alamos National Laboratory, Mail Stop J514, Los Alamos, New Mexico 87545, USA
    J Am Chem Soc 130:2408-9. 2008
  68. ncbi Sensing the chirality of Dawson lanthanide polyoxometalates [alpha1-LnP2W17O61]7- by multinuclear NMR spectroscopy
    Cécile Boglio
    Laboratoire de chimie inorganique et materiaux moleculaires UMR CNRS 7071, Institut de Chimie Moleculaire FR 2769, Universite Pierre et Marie Curie Paris 6, Case Courrier 42, 4 place Jussieu, Paris Cedex 05, France
    Chemistry 14:1532-40. 2008
    ..N-Phosphonomethyl-L-proline appears to be a convenient ligand to promote separation of the diastereomers and ultimately resolution of the enantiomers of [alpha(1)-Yb(H(2)O)(4)P(2)W(17)O(61)](7-)...
  69. ncbi Experimental and theoretical comparison of actinide and lanthanide bonding in M[N(EPR(2))(2)](3) complexes (M = U, Pu, La, Ce; E = S, Se, Te; R = Ph, iPr, H)
    Andrew J Gaunt
    Chemistry Division and Associate Directorate for Chemistry, Life, and Earth Sciences, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Inorg Chem 47:29-41. 2008
    ..The fundamental and practical importance of such studies of the role of the valence d and f orbitals in the bonding of the f elements is emphasized...
  70. ncbi Syntheses, structures, and sensitized lanthanide luminescence by Pt --> Ln (Ln = Eu, Nd, Yb) energy transfer for heteronuclear PtLn2 and Pt2Ln4 complexes with a terpyridyl-functionalized alkynyl ligand
    Xiu Ling Li
    State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China
    Inorg Chem 46:10892-900. 2007
    ..Ln distances being ca. 14.2 A. The Pt --> Ln energy transfer rate (kET) is 6.07 x 10(7) s(-1) for Pt2Nd4 (6) and 2.12 x 10(5) s(-1) for Pt2Yb4 (9) species...
  71. ncbi Luminescent dinuclear lanthanide complexes of 5-Me-HXTA
    Louise S Natrajan
    Department of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, U K
    Inorg Chem 46:10877-86. 2007
    ..The terbium complex displays a high quantum yield of around 50% in aqueous solution with a low detection limit of 1 x 10(-12) M, rendering this compound a potential candidate for time-resolved applications...
  72. ncbi Synthesis, characterization of the luminescent lanthanide complexes with (Z)-4-(4-methoxyphenoxy)-4-oxobut-2-enoic acid
    Guo Jian Duan
    College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
    Spectrochim Acta A Mol Biomol Spectrosc 69:427-31. 2008
    ..The strong luminescence emitting peaks at 616nm for Eu(III) and 547nm for Tb(III) can be observed, which could be attributed to the ligand has an enhanced effect to the luminescence intensity of the Eu and Tb...
  73. pmc Emission detected circular dichroism from long-lived excited states: application to chiral Eu(III) systems
    Françoise C Muller
    Department of Chemistry, San Jose State University, San Jose, California
    Chirality 19:826-32. 2007
    ..The results are compared with conventional CD measurements, and additional characteristics and potential applications of EDCD are presented...
  74. ncbi A robust and convergent synthesis of dipeptide-DOTAM conjugates as chelators for lanthanide ions: new PARACEST MRI agents
    Filip Wojciechowski
    Department of Chemistry, The University of Western Ontario, London, Ontario, Canada N6A 5B7
    Bioconjug Chem 18:1625-36. 2007
    ..Extension of the synthetic approach to a wide variety of amino acids is possible...
  75. ncbi Synthesis and structural properties of lanthanide complexes formed with tropolonate ligands
    Jian Zhang
    Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Inorg Chem 46:6473-82. 2007
    ..This analysis will aid us in optimizing ligand design for improved photophysical properties of the complex...
  76. doi Partial least-squares analysis of time decay data for Eu(III)-tetracycline complexes: simultaneous luminescent determination of tetracycline and oxytetracycline in bovine serum
    Gabriela A Ibañez
    Departamento de Quimica Analitica, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Suipacha 531, Rosario S2002LRK, Argentina
    Talanta 75:1028-34. 2008
    ..The results obtained by the developed method were statistically comparable to those obtained with high performance liquid chromatography...
  77. ncbi Sensitized near-infrared lanthanide luminescence from Nd(III)- and Yb(III)-based cyclen-ruthenium coordination conjugates
    Katell Sénéchal-David
    School of Chemistry, Centre for Synthesis and Chemical Biology, University of Dublin, Trinity College Dublin, Dublin 2, Ireland
    Inorg Chem 45:10040-2. 2006
    ..Excitation of the Ru(II) metal-to-ligand charge-transfer band in water gave rise to long-wavelength sensitized emission from the Yb(III) or Nd(III) centers, observed in the near-infrared...
  78. ncbi Heterometallic Ln/Hg compounds with fluorinated thiolate ligands
    Santanu Banerjee
    Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854 8087, USA
    Inorg Chem 43:6307-12. 2004
    ....
  79. ncbi Polymetallic lanthanide complexes with PAMAM-naphthalimide dendritic ligands: luminescent lanthanide complexes formed in solution
    Jason P Cross
    Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Am Chem Soc 126:16278-9. 2004
    ..0006, the good protection of the eight lanthanide cations bound in the dendrimer structure and the high absorptivity leads to the red emission from Eu3+ that is easily observed in solution under irradiation with 354 nm UV light...
  80. ncbi Stable 8-hydroxyquinolinate-based podates as efficient sensitizers of lanthanide near-infrared luminescence
    Steve Comby
    Laboratory of Lanthanide Supramolecular Chemistry, Ecole Polytechnique Federale de Lausanne EPFL, BCH 1402, CH 1015 Lausanne, Switzerland
    Inorg Chem 45:732-43. 2006
    ..04% and = 0.37%). In fact, TsoxMe yields one of the most luminescent Yb(III) compounds known in water, and this ligand appears to be suitable for the development of NIR probes for bioanalyses...
  81. ncbi Synthesis of metal-chelating lipids to sensitize lanthanide ions
    Bidhan C Roy
    Department of Chemistry, North Dakota State University, Fargo 58105, USA
    J Org Chem 68:3999-4007. 2003
    ..Liposomes from the lipid 18-Eu(3+) provided a probe that relies not only on the emission wavelengths of Eu(3+) but also on a reproducible lifetime that can be used for protein identification...
  82. ncbi An efficient design for the rigid assembly of four bidentate chromophores in water-stable highly luminescent lanthanide complexes
    Nicholas Chatterton
    Laboratoire de Chimie Inorganique et Biologique UMR E 3 CEA UJF, Departement de Recherche Fondamentale sur la Matiere Condensee, CEA Grenoble, 17 rue des Martyrs, 38054 Grenoble, Cedex 09, France
    Angew Chem Int Ed Engl 44:7595-8. 2005
  83. ncbi Chelating bis(thiophosphinic amidate)s as versatile supporting ligands for the group 3 metals. An application to the synthesis of highly active catalysts for intramolecular alkene hydroamination
    Young Kwan Kim
    Department of Chemistry, Montana State University, Bozeman, Montana 59717, USA
    J Am Chem Soc 125:9560-1. 2003
    ..These unusual pentacoordinate complexes exhibit very high activity as catalysts for intramolecular alkene hydroamination...
  84. ncbi Stable lanthanide luminescence agents highly emissive in aqueous solution: multidentate 2-hydroxyisophthalamide complexes of Sm(3+), Eu(3+), Tb(3+), Dy(3+)
    STEPHANE PETOUD
    Department of Chemistry, University of California, Berkeley, California 94720 1460, USA
    J Am Chem Soc 125:13324-5. 2003
    ..The low overlap of the four different Ln complexes enables their simultaneous detection and discrimination...
  85. ncbi A novel series of complexones with bis- or biazole structure as mixed ligands of paramagnetic contrast agents for MRI
    Elena P Mayoral
    Departamento Qui mica Orgánica y Biologi a, Facultad de Ciencias, UNED, Senda del Rey 9, 28040 Madrid, Spain
    Bioorg Med Chem 11:5555-67. 2003
    ..2, 5.6) or Gd(III)DTPA (4.30, 4.30). These improvements involve mainly increased hydration and slower rotational motions. In vitro toxicity experiments are reported...
  86. ncbi Solid-supported synthesis of polymerizable lanthanide-ion chelating lipids for protein detection
    Suad Nadi
    Department of Chemistry and Molecular Biology, North Dakota State University, Fargo, North Dakota 58105, USA
    Inorg Chem 44:2234-44. 2005
    ..We also demonstrate that the resulting polymerized liposomes (containing Eu3+) possess the appropriate luminescence properties for the qualitative and quantitative determination of proteins...
  87. ncbi Syntheses, crystal structures, and luminescent properties of novel layered lanthanide sulfonate-phosphonates
    Jun Ling Song
    State Key Laboratory of Structure Chemistry, Fujian Institute of Research on the Structure of Matter, The Chinese Academy of Sciences, Fuzhou 350002, P R China
    Inorg Chem 43:5630-4. 2004
    ..The luminescent properties of compounds 3 and 4 have also been studied...
  88. ncbi Detection strategies for bioassays based on luminescent lanthanide complexes and signal amplification
    Tanja Steinkamp
    Department of Chemical Analysis and MESA Institute for Nanotechnology, University of Twente, P O Box 217, 7500 AE Enschede, The Netherlands
    Anal Bioanal Chem 380:24-30. 2004
    ..In this paper, the basic properties and major applications of both techniques are presented, and their future perspectives are discussed critically...
  89. ncbi Tuning the decay time of lanthanide-based near infrared luminescence from micro- to milliseconds through d-->f energy transfer in discrete heterobimetallic complexes
    Stéphane Torelli
    Department of Inorganic, Analytical and Applied Chemistry, University of Geneva, 30 quai E Ansermet, 1211 Geneva 4, Switzerland
    Chemistry 11:3228-42. 2005
    ..The origin of this effect, together with its rational control for programming optical functions in discrete heterobimetallic entities, are discussed...
  90. ncbi Enhanced lanthanide luminescence using silver nanostructures: opportunities for a new class of probes with exceptional spectral characteristics
    Meng Wu
    Center for Fluorescence Spectroscopy, Department of Biochemistry, and Molecular Biology, Medical Biotechnology Center, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    J Fluoresc 15:53-9. 2005
    ....
  91. ncbi Synthesis of a bifunctional monophosphinic acid DOTA analogue ligand and its lanthanide(III) complexes. A gadolinium(III) complex endowed with an optimal water exchange rate for MRI applications
    Jakub Rudovský
    Department of Inorganic Chemistry, Universita Karlova, Hlavova 2030, 128 40, Prague 2, Czech Republic
    Org Biomol Chem 3:112-7. 2005
    ..These results prompt the use of [Gd(H2O)(DO3APABn)]- as a building block for the set-up of highly efficient macromolecular MRI contrast agents...
  92. ncbi Lanthanide/ATP interaction in water mediated by luminescent hemispherical-shaped complexes
    Samir Mameri
    LCM, ECPM, 25 rue Becquerel, 67087 Strasbourg Cedex 02, France
    Inorg Chem 43:1819-21. 2004
    ..0. The interaction of these anions with the complex was investigated by means of absorption and emission spectroscopies. With ATP(4)(-), ES-MS and (31)P NMR experiments revealed the formation of a [Ln.L.(ATP)](3)(-) ternary species...
  93. ncbi Lanthanide spectroscopic studies of the dinuclear and Mg(II)-dependent PvuII restriction endonuclease
    Lori M Bowen
    Department of Chemistry and Biochemistry, University of Missouri St Louis, St Louis, Missouri 63121, USA
    Biochemistry 43:15286-95. 2004
    ....
  94. ncbi Complexation of trivalent lanthanide cations by erythritol in the solid state. The crystal structure and FT-IR study of 2EuCl3.2C4H10O4.7H2O
    Limin Yang
    The State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
    Carbohydr Res 339:1679-87. 2004
    ..The OH, CO stretching and other vibrations are shifted in the IR spectra of the complexes and the results are consistent with the crystal structure...
  95. ncbi Syntheses, structures, near-infrared and visible luminescence, and magnetic properties of lanthanide-organic frameworks with an imidazole-containing flexible ligand
    Zheng Hua Zhang
    Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China
    Inorg Chem 45:2896-902. 2006
    ..8 k...
  96. ncbi Structural, luminescence, and NMR studies of the reversible binding of acetate, lactate, citrate, and selected amino acids to chiral diaqua ytterbium, gadolinium, and europium complexes
    Rachel S Dickins
    Department of Chemistry, University of Durham, South Road, UK
    J Am Chem Soc 124:12697-705. 2002
    ..Crystal structures of the Gly and Ser adducts confirm this. In peptides and proteins (e.g. albumin) containing Glu or Asp residues, the more basic side chain carboxylate may chelate to the Ln ion, displacing both waters...
  97. ncbi Solution and structural investigations of ligand preorganization in trivalent lanthanide complexes of bicyclic malonamides
    Bevin W Parks
    Chemistry Department, University of Oregon, Eugene, 97403 1253, USA
    Inorg Chem 45:1498-507. 2006
    ..These results support the conclusion that rational ligand design can lead to compounds that enhance the binding affinities within a ligand class...
  98. ncbi Synthesis, characterization and luminescence property of N,N'-di(pyridine N-oxide-2-yl)pyridine-2,6-dicarboxamide and corresponding lanthanide (III) complexes
    Hai Jun Zhang
    College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China
    Spectrochim Acta A Mol Biomol Spectrosc 66:289-94. 2007
    ....
  99. ncbi Lanthanide complexes of a picolinate ligand derived from 1,4,7-triazacyclononane with potential application in magnetic resonance imaging and time-resolved luminescence imaging
    Aline Nonat
    Laboratoire de Reconnaissance Ionique, Service de Chimie Inorganique et Biologique UMR E 3 CEA UJF, CEA DSM Département de Recherche Fondamentale sur la Matière Condensée, CEA Grenoble, 38054 Grenoble Cedex 09, France
    Chemistry 12:7133-50. 2006
    ..The optimisation of the electronic relaxation by ligand design is especially important to achieve high relaxivity in the new generation macromolecular complexes with long rotational correlation times...
  100. ncbi Paramagnetic lanthanide(III) complexes as pH-sensitive chemical exchange saturation transfer (CEST) contrast agents for MRI applications
    Silvio Aime
    Dipartimento di Chimica I F M, Universita degli Studi di Torino, Torino, Italy
    Magn Reson Med 47:639-48. 2002
    ..40 ppm downfield H2O signal at 312K) and amide protons, respectively, produces a pH-dependent CEST effect which is the function of the concentration ratio of the two complexes...
  101. ncbi Use of dipicolinate-based complexes for producing ion-imprinted polystyrene resins for the extraction of yttrium-90 and heavy lanthanide cations
    Anne Sophie Chauvin
    Laboratory of Lanthanide Supramolecular Chemistry, Ecole Polytechnique Federale de Lausanne, BCH 1402, 1015 Lausanne, Switzerland
    Chemistry 12:6852-64. 2006
    ....

Research Grants73

  1. Flourescent Ceramic Nanoprobes (RMI)
    TIMOTHY BOYLE; Fiscal Year: 2008
    ..All of the innovations uncovered during the preparation of these nanoprobes will be shared in order to benefit medical research applications beyond those proposed in this investigation. ..
  2. Flourescent Ceramic Nanoprobes (RMI)
    TIMOTHY BOYLE; Fiscal Year: 2007
    ..All of the innovations uncovered during the preparation of these nanoprobes will be shared in order to benefit medical research applications beyond those proposed in this investigation. ..
  3. Microarrays for DNA binding proteins
    Tomasz Heyduk; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  4. INTER & INTRAMOLECULAR COMMUNICATIONS IN TRANSCRIPTION
    Tomasz Heyduk; Fiscal Year: 2006
    ..It is expected that a detailed understanding of the role of several protein-protein and protein-DNA contacts in RNA polymerase function will be obtained. ..
  5. STRUCTURAL AND MECHANISTIC STUDIES OF PHOSPHONATASE
    Karen Allen; Fiscal Year: 2005
    ..The goal of these studies is to derive an understanding of how the enzyme superfamily active site has been adapted to catalyze C-X, P-O and C-P bond cleavage in a variety of different substrate structures. ..
  6. MOLECULAR BEACONS FOR PROTEIN DETECTION
    Tomasz Heyduk; Fiscal Year: 2005
    ..abstract_text> ..
  7. INTER AND INTRAMOLECULAR COMMUNICATIONS IN TRANSCRIPTION
    Tomasz Heyduk; Fiscal Year: 2010
    ..Such information will enable development of new antibiotics targeting bacterial RNA polymerase. Development of new antibiotics targeting new targets is essential to combating emerging antibiotic-resistant strains. ..
  8. FACTORS STABILIZING RNA STRUCTURES
    David Draper; Fiscal Year: 2005
    ..The ability to predict the Mg2+-dependent folding free energies of RNA tertiary conformations would be useful in a number of contexts. ..
  9. Coupling Reactions-Methods Development and Applications
    GARY MOLANDER; Fiscal Year: 2005
    ..These types of transformations are anticipated to have broad generality and will thus prove valuable for the rapid, efficient, and unique assembly of complex organic molecules throughout the pharmaceutical industry and beyond. ..
  10. INTER & INTRAMOLECULAR COMMUNICATIONS IN TRANSCRIPTION
    Tomasz Heyduk; Fiscal Year: 2005
    ..It is expected that a detailed understanding of the role of several protein-protein and protein-DNA contacts in RNA polymerase function will be obtained. ..
  11. STRUCTURAL DYNAMICS OF ACTIN AND MYOSIN INTERACTIONS
    DOUGLAS ROOT; Fiscal Year: 2005
    ..Recent progress being made toward achieving such an understanding of this critical process in motility and the proposed research will contribute to this effort. ..
  12. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2005
    ..4) Carbometalation/cyclization reactions will be explored utilizing organochromium species. 5) Ligands and catalytic systems designed for asymmetric synthesis will be explored. ..
  13. INTER & INTRAMOLECULAR COMMUNICATIONS IN TRANSCRIPTION
    Tomasz Heyduk; Fiscal Year: 2004
    ..It is expected that a detailed understanding of the role of several protein-protein and protein-DNA contacts in RNA polymerase function will be obtained. ..
  14. STRUCTURAL AND MECHANISTIC STUDIES OF PHOSPHONATASE
    Karen Allen; Fiscal Year: 2004
    ..The goal of these studies is to derive an understanding of how the enzyme superfamily active site has been adapted to catalyze C-X, P-O and C-P bond cleavage in a variety of different substrate structures. ..
  15. Mechanisms and Function in HAD Phosphotransferases
    Karen Allen; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  16. PROGRAM IN MOLECULAR AND COMPUTATIONAL BIOPHYSICS
    David Draper; Fiscal Year: 2007
    ....
  17. Coupling Reactions-Methods Development and Applications
    GARY MOLANDER; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  18. Organotrifluoroborates in Selective Organic Synthesis
    Gary A Molander; Fiscal Year: 2010
    ..In this way, new drug entities can be delivered to the public more rapidly and efficiently at lower cost. ..
  19. Development of Heterosubstituted Organotrifluoroborates
    GARY MOLANDER; Fiscal Year: 2009
    ....
  20. INTER AND INTRAMOLECULAR COMMUNICATIONS IN TRANSCRIPTION
    Tomasz Heyduk; Fiscal Year: 2009
    ..Such information will enable development of new antibiotics targeting bacterial RNA polymerase. Development of new antibiotics targeting new targets is essential to combating emerging antibiotic-resistant strains. ..
  21. Mechanisms and Function in HAD Phosphotransferases
    Karen Allen; Fiscal Year: 2009
    ..abstract_text> ..
  22. Development of Heterosubstituted Organotrifluoroborates
    GARY MOLANDER; Fiscal Year: 2008
    ....
  23. Frequency Shifting Paramagnetic Agents: Quantitative MRI of Exchange Effects
    Elena Vinogradov; Fiscal Year: 2008
    ..We propose to develop such a paradigm starting from the basic theoretical model all the way through to successful quantitative detection in-vivo. [unreadable] [unreadable] [unreadable]..
  24. FACTORS STABILIZING RNA STRUCTURES
    David Draper; Fiscal Year: 2009
    ..Drugs which stabilize or alter specific critical RNA structures could have wide therapeutical applications. An understanding of the forces that stabilize RNA structures could aid in selection of drug targets and the design of new drugs. ..
  25. Nogo's role in intracellular trafficking
    Noam Harel; Fiscal Year: 2008
    ....
  26. Coupling Reactions-Methods Development and Applications
    GARY MOLANDER; Fiscal Year: 2007
    ..abstract_text> ..
  27. FACTORS STABILIZING RNA STRUCTURES
    David Draper; Fiscal Year: 2007
    ..An understanding of the forces that stabilize RNA structures could aid in selection of drug targets and the design of new drugs. ..
  28. Nogo's role in intracellular trafficking
    Noam Harel; Fiscal Year: 2007
    ....
  29. Portable Analyzer for On-site Monitoring of Worker Exposure to Toxic Metals
    Charles Timchalk; Fiscal Year: 2007
    ..Ultimately, the sensor for metal ions will be combined with the sensor for creatinine so that the exposure monitoring can be performed with "spot" urine instead of 24-hr urine. [unreadable] [unreadable] [unreadable]..
  30. STRUCTURAL DYNAMICS OF ACTIN AND MYOSIN INTERACTIONS
    DOUGLAS ROOT; Fiscal Year: 2004
    ..Recent progress being made toward achieving such an understanding of this critical process in motility and the proposed research will contribute to this effort. ..
  31. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2004
    ..4) Carbometalation/cyclization reactions will be explored utilizing organochromium species. 5) Ligands and catalytic systems designed for asymmetric synthesis will be explored. ..
  32. INTRAMOLECULAR REDUCTIVE COUPLING REACTIONS
    GARY MOLANDER; Fiscal Year: 2000
    ..The study of the mechanism of action of GPI-anchoring inhibitors may lead to therapies for parasitic protozoan infections. ..
  33. CATALYTIC PROCESSES FOR SELECTIVE ORGANIC SYTHESIS
    GARY MOLANDER; Fiscal Year: 2000
    ..4) Cyclization reactions of polyolefins, dieneynes, enediynes, etc. involving sequential reactions wherein the cyclizations are terminated by silylation, boration, hydrogenolysis, or beta-hydride elimination. ..
  34. INTRAMOLECULAR REDUCTIVE COUPLING REACTIONS
    GARY MOLANDER; Fiscal Year: 2000
    ..The study of the mechanism of action of GPI-anchoring inhibitors may lead to therapies for parasitic protozoan infections. ..
  35. INTER AND INTRAMOLECULAR COMMUNICATIONS IN TRANSCRIPTION
    Tomasz Heyduk; Fiscal Year: 2000
    ..The applicant hopes to identify critical determinants of initial promoter recognition and productive elongation, complex formation. ..
  36. FACTORS STABILIZING RNA STRUCTURES
    David Draper; Fiscal Year: 2000
    ..This information will fill in a crucial aspect of non-canonical and tertiary RNA folding energetics. ..
  37. RIBOSOMAL PROTEIN S4 INTERACTIONS WITH MRNA AND RRNA
    David Draper; Fiscal Year: 2000
    ..Results from these studies should contribute to a basic understanding of protein-RNA recognition mechanisms and RNA folding, as well as elucidation of specific S4 roles in translational regulation and ribosome assembly. ..
  38. CATALYTIC PROCESSES FOR SELECTIVE ORGANIC SYTHESIS
    GARY MOLANDER; Fiscal Year: 1999
    ..4) Cyclization reactions of polyolefins, dieneynes, enediynes, etc. involving sequential reactions wherein the cyclizations are terminated by silylation, boration, hydrogenolysis, or beta-hydride elimination. ..
  39. STRUCTURAL AND MECHANISTIC STUDIES OF PHOSPHONATASE
    Karen Allen; Fiscal Year: 2000
    ..The goal of these studies is to derive an understanding of how the enzyme superfamily active site has been adapted to catalyze C-X, P-O and C-P bond cleavage in a variety of different substrate structures. ..
  40. INTER AND INTRAMOLECULAR COMMUNICATIONS IN TRANSCRIPTION
    Tomasz Heyduk; Fiscal Year: 1999
    ..The applicant hopes to identify critical determinants of initial promoter recognition and productive elongation, complex formation. ..
  41. RIBOSOMAL PROTEIN S4 INTERACTIONS WITH MRNA AND RRNA
    David Draper; Fiscal Year: 1999
    ..Results from these studies should contribute to a basic understanding of protein-RNA recognition mechanisms and RNA folding, as well as elucidation of specific S4 roles in translational regulation and ribosome assembly. ..
  42. FACTORS STABILIZING RNA STRUCTURES
    David Draper; Fiscal Year: 1999
    ..This information will fill in a crucial aspect of non-canonical and tertiary RNA folding energetics. ..
  43. FACTORS STABILIZING RNA STRUCTURES
    David Draper; Fiscal Year: 2001
    ..This information will fill in a crucial aspect of non-canonical and tertiary RNA folding energetics. ..
  44. INTRAMOLECULAR REDUCTIVE COUPLING REACTIONS
    GARY MOLANDER; Fiscal Year: 2001
    ..The study of the mechanism of action of GPI-anchoring inhibitors may lead to therapies for parasitic protozoan infections. ..
  45. CATALYTIC PROCESSES FOR SELECTIVE ORGANIC SYTHESIS
    GARY MOLANDER; Fiscal Year: 2001
    ..4) Cyclization reactions of polyolefins, dieneynes, enediynes, etc. involving sequential reactions wherein the cyclizations are terminated by silylation, boration, hydrogenolysis, or beta-hydride elimination. ..
  46. INTER AND INTRAMOLECULAR COMMUNICATIONS IN TRANSCRIPTION
    Tomasz Heyduk; Fiscal Year: 2002
    ..The applicant hopes to identify critical determinants of initial promoter recognition and productive elongation, complex formation. ..
  47. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2003
    ..4) Carbometalation/cyclization reactions will be explored utilizing organochromium species. 5) Ligands and catalytic systems designed for asymmetric synthesis will be explored. ..
  48. STRUCTURAL DYNAMICS OF ACTIN AND MYOSIN INTERACTIONS
    DOUGLAS ROOT; Fiscal Year: 2003
    ..Recent progress being made toward achieving such an understanding of this critical process in motility and the proposed research will contribute to this effort. ..
  49. INTRAMOLECULAR REDUCTIVE COUPLING REACTIONS
    GARY MOLANDER; Fiscal Year: 2003
    ..The study of the mechanism of action of GPI-anchoring inhibitors may lead to therapies for parasitic protozoan infections. ..
  50. INTRAMOLECULAR REDUCTIVE COUPLING REACTIONS
    GARY MOLANDER; Fiscal Year: 2002
    ..The study of the mechanism of action of GPI-anchoring inhibitors may lead to therapies for parasitic protozoan infections. ..
  51. STRUCTURAL AND MECHANISTIC STUDIES OF PHOSPHONATASE
    Karen Allen; Fiscal Year: 2002
    ..The goal of these studies is to derive an understanding of how the enzyme superfamily active site has been adapted to catalyze C-X, P-O and C-P bond cleavage in a variety of different substrate structures. ..
  52. FACTORS STABILIZING RNA STRUCTURES
    David Draper; Fiscal Year: 2002
    ..This information will fill in a crucial aspect of non-canonical and tertiary RNA folding energetics. ..
  53. STRUCTURAL AND MECHANISTIC STUDIES OF PHOSPHONATASE
    Karen Allen; Fiscal Year: 2001
    ..The goal of these studies is to derive an understanding of how the enzyme superfamily active site has been adapted to catalyze C-X, P-O and C-P bond cleavage in a variety of different substrate structures. ..
  54. STRUCTURAL AND MECHANISTIC STUDIES OF PHOSPHONATASE
    Karen Allen; Fiscal Year: 2003
    ..The goal of these studies is to derive an understanding of how the enzyme superfamily active site has been adapted to catalyze C-X, P-O and C-P bond cleavage in a variety of different substrate structures. ..
  55. INTER AND INTRAMOLECULAR COMMUNICATIONS IN TRANSCRIPTION
    Tomasz Heyduk; Fiscal Year: 2001
    ..The applicant hopes to identify critical determinants of initial promoter recognition and productive elongation, complex formation. ..
  56. FACTORS STABILIZING RNA STRUCTURES
    David Draper; Fiscal Year: 2003
    ..The ability to predict the Mg2+-dependent folding free energies of RNA tertiary conformations would be useful in a number of contexts. ..
  57. CATALYTIC PROCESSES FOR SELECTIVE ORGANIC SYTHESIS
    GARY MOLANDER; Fiscal Year: 2002
    ..4) Cyclization reactions of polyolefins, dieneynes, enediynes, etc. involving sequential reactions wherein the cyclizations are terminated by silylation, boration, hydrogenolysis, or beta-hydride elimination. ..
  58. Novel Chelators for Highly Efficient Removal of Toxic Heavy Metals in Humans
    Wassana Yantasee; Fiscal Year: 2008
    ....
  59. Mechanisms and Function in HAD Phosphotransferases
    Karen Allen; Fiscal Year: 2008
    ..abstract_text> ..
  60. Mechanisms and Function in HAD Phosphotransferases
    Karen Allen; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  61. FACTORS STABILIZING RNA STRUCTURES
    David Draper; Fiscal Year: 2009
    ..Drugs which stabilize or alter specific critical RNA structures could have wide therapeutical applications. An understanding of the forces that stabilize RNA structures could aid in selection of drug targets and the design of new drugs. ..
  62. FACTORS STABILIZING RNA STRUCTURES
    David Draper; Fiscal Year: 2006
    ..The ability to predict the Mg2+-dependent folding free energies of RNA tertiary conformations would be useful in a number of contexts. ..
  63. FACTORS STABILIZING RNA STRUCTURES
    David Draper; Fiscal Year: 2004
    ..The ability to predict the Mg2+-dependent folding free energies of RNA tertiary conformations would be useful in a number of contexts. ..
  64. PROGRAM IN MOLECULAR AND COMPUTATIONAL BIOPHYSICS
    David Draper; Fiscal Year: 2008
    ....
  65. Frequency Shifting Paramagnetic Agents: Quantitative MRI of Exchange Effects
    Elena Vinogradov; Fiscal Year: 2007
    ..We propose to develop such a paradigm starting from the basic theoretical model all the way through to successful quantitative detection in-vivo. [unreadable] [unreadable] [unreadable]..
  66. RIBOSOMAL PROTEIN S4 INTERACTIONS WITH MRNA AND RRNA
    David Draper; Fiscal Year: 2001
    ..Results from these studies should contribute to a basic understanding of protein-RNA recognition mechanisms and RNA folding, as well as elucidation of specific S4 roles in translational regulation and ribosome assembly. ..
  67. FACTORS STABILIZING RNA STRUCTURES
    David Draper; Fiscal Year: 2008
    ..An understanding of the forces that stabilize RNA structures could aid in selection of drug targets and the design of new drugs. ..