lanthanoid series elements

Summary

Summary: Elements of the lanthanoid series including atomic number 57 (LATHANUM) through atomic number 71 (LUTETIUM).

Top Publications

  1. ncbi Comparison of dissociation-enhanced lanthanide fluorescent immunoassays to enzyme-linked immunosorbent assays for detection of staphylococcal enterotoxin B, Yersinia pestis-specific F1 antigen, and Venezuelan equine encephalitis virus
    D R Smith
    Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA
    Clin Diagn Lab Immunol 8:1070-5. 2001
  2. ncbi Synthesis, characterization, and application of Eu(III), Tb(III), Sm(III), and Dy(III) lanthanide chelate nanoparticle labels
    Petri Huhtinen
    Department of Biotechnology, University of Turku, , FIN-20520 Turku, Finland
    Anal Chem 77:2643-8. 2005
  3. ncbi Protein alignment by a coexpressed lanthanide-binding tag for the measurement of residual dipolar couplings
    Jens Wöhnert
    Institut für Organische Chemie und Chemische Biologie, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe Universitat Frankfurt, Marie Curie Strasse 11, 60439 Frankfurt M, Germany
    J Am Chem Soc 125:13338-9. 2003
  4. ncbi Structural origin of the high affinity of a chemically evolved lanthanide-binding peptide
    Mark Nitz
    Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Angew Chem Int Ed Engl 43:3682-5. 2004
  5. ncbi Lanthanide-binding peptides for NMR measurements of residual dipolar couplings and paramagnetic effects from multiple angles
    Xun Cheng Su
    Research School of Chemistry, Australian National University, Canberra ACT 0200, Australia
    J Am Chem Soc 130:1681-7. 2008
  6. ncbi From antenna to assay: lessons learned in lanthanide luminescence
    Evan G Moore
    Department of Chemistry, University of California, Berkeley, and Chemical Sciences Division, Lawrence Berkeley National Laboratories, Berkeley, California 94720, USA
    Acc Chem Res 42:542-52. 2009
  7. ncbi Optimization of time-resolved fluorescence assay for detection of europium-tetraazacyclododecyltetraacetic acid-labeled ligand-receptor interactions
    Channa R De Silva
    Department of Chemistry, University of Arizona, Tucson, AZ 85721, USA
    Anal Biochem 398:15-23. 2010
  8. ncbi Lanthanide luminescence for functional materials and bio-sciences
    Svetlana V Eliseeva
    Laboratory of Lanthanide Supramolecular Chemistry, Swiss Federal Institute of Technology, Lausanne EPFL
    Chem Soc Rev 39:189-227. 2010
  9. ncbi Highly sensitive protein detection based on lanthanide chelates with antenna ligands providing a linear range of five orders of magnitude
    Thole Zuchner
    Institute of Bioanalytical Chemistry, Center of Biotechnology and Biomedicine, Faculty of Chemistry and Mineralogy, Leipzig University, Deutscher Platz 5, 04103 Leipzig, Germany
    Anal Chem 81:9449-53. 2009
  10. ncbi Design, synthesis, and evaluation of a lanthanide chelating protein probe: CLaNP-5 yields predictable paramagnetic effects independent of environment
    Peter H J Keizers
    Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, Post Office Box 9502, 2300 RA Leiden, The Netherlands
    J Am Chem Soc 130:14802-12. 2008

Research Grants

  1. Flourescent Ceramic Nanoprobes (RMI)
    TIMOTHY BOYLE; Fiscal Year: 2007
  2. Microarrays for DNA binding proteins
    Tomasz Heyduk; Fiscal Year: 2006
  3. INTER & INTRAMOLECULAR COMMUNICATIONS IN TRANSCRIPTION
    Tomasz Heyduk; Fiscal Year: 2006
  4. STRUCTURAL AND MECHANISTIC STUDIES OF PHOSPHONATASE
    Karen Allen; Fiscal Year: 2005
  5. MOLECULAR BEACONS FOR PROTEIN DETECTION
    Tomasz Heyduk; Fiscal Year: 2005
  6. INTER AND INTRAMOLECULAR COMMUNICATIONS IN TRANSCRIPTION
    Tomasz Heyduk; Fiscal Year: 2010
  7. STRUCTURAL DYNAMICS OF ACTIN AND MYOSIN INTERACTIONS
    DOUGLAS ROOT; Fiscal Year: 2005
  8. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2005
  9. Mechanisms and Function in HAD Phosphotransferases
    Karen Allen; Fiscal Year: 2007
  10. PROGRAM IN MOLECULAR AND COMPUTATIONAL BIOPHYSICS
    David Draper; Fiscal Year: 2007

Detail Information

Publications170 found, 100 shown here

  1. ncbi Comparison of dissociation-enhanced lanthanide fluorescent immunoassays to enzyme-linked immunosorbent assays for detection of staphylococcal enterotoxin B, Yersinia pestis-specific F1 antigen, and Venezuelan equine encephalitis virus
    D R Smith
    Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA
    Clin Diagn Lab Immunol 8:1070-5. 2001
    ....
  2. ncbi Synthesis, characterization, and application of Eu(III), Tb(III), Sm(III), and Dy(III) lanthanide chelate nanoparticle labels
    Petri Huhtinen
    Department of Biotechnology, University of Turku, , FIN-20520 Turku, Finland
    Anal Chem 77:2643-8. 2005
    ..The spectral and functional properties of the lanthanide-embedded polystyrene nanoparticles developed here suggest that the technology is applicable for high-sensitivity multicolor assays...
  3. ncbi Protein alignment by a coexpressed lanthanide-binding tag for the measurement of residual dipolar couplings
    Jens Wöhnert
    Institut für Organische Chemie und Chemische Biologie, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe Universitat Frankfurt, Marie Curie Strasse 11, 60439 Frankfurt M, Germany
    J Am Chem Soc 125:13338-9. 2003
    ..6 to 6.1 Hz for Dy3+, while an opposite alignment tensor is observed for Tm3+ (4.5 to -2.9 Hz) at 800 MHz. Experimental RDCs are in excellent agreement with those predicted on the basis of the X-ray structure of the protein...
  4. ncbi Structural origin of the high affinity of a chemically evolved lanthanide-binding peptide
    Mark Nitz
    Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Angew Chem Int Ed Engl 43:3682-5. 2004
  5. ncbi Lanthanide-binding peptides for NMR measurements of residual dipolar couplings and paramagnetic effects from multiple angles
    Xun Cheng Su
    Research School of Chemistry, Australian National University, Canberra ACT 0200, Australia
    J Am Chem Soc 130:1681-7. 2008
    ....
  6. ncbi From antenna to assay: lessons learned in lanthanide luminescence
    Evan G Moore
    Department of Chemistry, University of California, Berkeley, and Chemical Sciences Division, Lawrence Berkeley National Laboratories, Berkeley, California 94720, USA
    Acc Chem Res 42:542-52. 2009
    ..Lastly, we describe a Tb(III)-IAM compound--now carried through to commercial availability--that offers improved performance in the common HTRF platform and has the potential to vastly improve sensitivity...
  7. ncbi Optimization of time-resolved fluorescence assay for detection of europium-tetraazacyclododecyltetraacetic acid-labeled ligand-receptor interactions
    Channa R De Silva
    Department of Chemistry, University of Arizona, Tucson, AZ 85721, USA
    Anal Biochem 398:15-23. 2010
    ..The modified assay provides superior results and is appropriate for high-throughput screening of ligand libraries...
  8. ncbi Lanthanide luminescence for functional materials and bio-sciences
    Svetlana V Eliseeva
    Laboratory of Lanthanide Supramolecular Chemistry, Swiss Federal Institute of Technology, Lausanne EPFL
    Chem Soc Rev 39:189-227. 2010
    ....
  9. ncbi Highly sensitive protein detection based on lanthanide chelates with antenna ligands providing a linear range of five orders of magnitude
    Thole Zuchner
    Institute of Bioanalytical Chemistry, Center of Biotechnology and Biomedicine, Faculty of Chemistry and Mineralogy, Leipzig University, Deutscher Platz 5, 04103 Leipzig, Germany
    Anal Chem 81:9449-53. 2009
    ..In addition, the new compound offers multiplexing capabilities...
  10. ncbi Design, synthesis, and evaluation of a lanthanide chelating protein probe: CLaNP-5 yields predictable paramagnetic effects independent of environment
    Peter H J Keizers
    Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, Post Office Box 9502, 2300 RA Leiden, The Netherlands
    J Am Chem Soc 130:14802-12. 2008
    ..These findings designate CLaNP-5 as a protein probe to deliver unambiguous high quality structural restraints in studies on protein-protein and protein-ligand interactions...
  11. ncbi Novel techniques for weak alignment of proteins in solution using chemical tags coordinating lanthanide ions
    Takahisa Ikegami
    Max-Planck Institute for Biophysical Chemistry, Department of NMR Based Structural Biology, University of Frankfurt am Fassberg 11, , Germany
    J Biomol NMR 29:339-49. 2004
    ..We observed residual (15)N,(1)H-dipolar couplings of up to 8 Hz at 800 MHz induced by a single alignment tensor from this tag...
  12. ncbi Double-lanthanide-binding tags: design, photophysical properties, and NMR applications
    Langdon J Martin
    Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 129:7106-13. 2007
    ..Together, these results indicate that dLBTs will be valuable chemical tools for biophysical applications leading to new approaches for studying the structure, function, and dynamics of proteins...
  13. ncbi A caged lanthanide complex as a paramagnetic shift agent for protein NMR
    Miguel Prudêncio
    Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    Chemistry 10:3252-60. 2004
    ..The molecule exists in several isomeric forms with different paramagnetic tensors; this provides a fast way to obtain long-range distance restraints...
  14. ncbi Paramagnetism-based NMR restraints provide maximum allowed probabilities for the different conformations of partially independent protein domains
    Ivano Bertini
    Magnetic Resonance Center CERM, University of Florence, Via Luigi Sacconi 6, 50019, Sesto Fiorentino, Italy
    J Am Chem Soc 129:12786-94. 2007
    ..Such variety is somewhat reduced in the calmodulin-alpha-synuclein adduct, which however still retains high flexibility. The flexibility of the calmodulin-alpha-synuclein adduct is an unexpected result of this research...
  15. ncbi Increased paramagnetic effect of a lanthanide protein probe by two-point attachment
    Peter H J Keizers
    Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    J Am Chem Soc 129:9292-3. 2007
  16. ncbi Site-specific labelling of proteins with a rigid lanthanide-binding tag
    Xun-Cheng Su
    Research School of Chemistry, Australian National University Canberra, ACT 0200, Australia
    Chembiochem 7:1599-604. 2006
    ....
  17. ncbi NMR structure determination of protein-ligand complexes by lanthanide labeling
    Guido Pintacuda
    Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia
    Acc Chem Res 40:206-12. 2007
    ..Strategies for site-specific incorporation of lanthanide ions into proteins are summarized...
  18. ncbi Two new chiral EDTA-based metal chelates for weak alignment of proteins in solution
    Peter Haberz
    Max-Planck Institute for Biophysical Chemistry, Department of NMR-based Structural Biology, Am Fassberg 11, , Germany
    Org Lett 8:1275-8. 2006
    ..Alignment tensors for the new tags are linearly independent compared to those of previously published tags...
  19. ncbi A dipicolinic acid tag for rigid lanthanide tagging of proteins and paramagnetic NMR spectroscopy
    Xun Cheng Su
    Research School of Chemistry, Australian National University, Canberra ACT 0200, Australia
    J Am Chem Soc 130:10486-7. 2008
    ..The close proximity of the lanthanide ion promotes accurate determinations of magnetic susceptibility anisotropy tensors. In addition, the small size of the tag makes it highly suitable for studies of intermolecular interactions...
  20. ncbi Accurate solution structures of proteins from X-ray data and a minimal set of NMR data: calmodulin-peptide complexes as examples
    Ivano Bertini
    Magnetic Resonance Center CERM, University of Florence, Via Luigi Sacconi 6, 50019 Sesto Fiorentino, Italy
    J Am Chem Soc 131:5134-44. 2009
    ....
  21. ncbi Two-point anchoring of a lanthanide-binding peptide to a target protein enhances the paramagnetic anisotropic effect
    Tomohide Saio
    Graduate School of Life Science, Hokkaido University, Sapporo, 001 0021, Japan
    J Biomol NMR 44:157-66. 2009
    ..Though there is slight residual mobility of the lanthanide-binding tag, the present tag provides a higher anisotropic paramagnetic effect...
  22. ncbi Intermolecular dynamics studied by paramagnetic tagging
    Xingfu Xu
    Institute of Chemistry, Leiden University, P O Box 9502, 2300 RA, Leiden, The Netherlands
    J Biomol NMR 43:247-54. 2009
    ..The applied method provides a simple and straightforward way to observe dynamics in protein complexes or domain-domain mobility without the need for external alignment media...
  23. ncbi Paramagnetically induced residual dipolar couplings for solution structure determination of lanthanide binding proteins
    Renato Barbieri
    Magnetic Resonance Center and Department of Chemistry, University of Florence, Via Luigi Sacconi 6, 50019, Sesto Fiorentino, Italy
    J Am Chem Soc 124:5581-7. 2002
    ..The effect of mobility is also assessed. In principle, information on the mobility can be obtained with a number of lanthanide ions >5, or by combining a smaller number of lanthanide ions with a few orienting devices...
  24. ncbi Progress in lanthanides as luminescent probes
    I Hemmilä
    Perkin Elmer Life and Analytical Sciences, Wallac Oy, P O Box 10, Fin 20101, Turku, Finland
    J Fluoresc 15:529-42. 2005
    ..This review gives a short overview of recent development of lanthanide chelate-labels and discusses in more details of energy levels and their exploitation in new assay formats...
  25. ncbi Lanthanide labeling offers fast NMR approach to 3D structure determinations of protein-protein complexes
    Guido Pintacuda
    Research School of Chemistry, Australian National University, Canberra ACT 0200, Australia
    J Am Chem Soc 128:3696-702. 2006
    ..Degeneracies in the mutual orientation of the protein structures were resolved by the use of two different lanthanide ions, Dy3+ and Er3+...
  26. ncbi Synthesis, infrared and fluorescence spectra of lanthanide complexes with a new amide-based 1,3,4-oxadiazole derivative
    Xiao Liang Tang
    Department of Chemistry and State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
    Spectrochim Acta A Mol Biomol Spectrosc 68:349-53. 2007
    ..Under the excitation of UV light, these complexes exhibit characteristic fluorescence of europium and terbium ions. The solvent factors influencing the fluorescent intensity were discussed...
  27. ncbi A bridge to coordination isomer selection in lanthanide(III) DOTA-tetraamide complexes
    Jeff Vipond
    Department of Chemistry, University of Texas at Dallas, P O Box 830660, Richardson, Texas 75083 0688, USA
    Inorg Chem 46:2584-95. 2007
    ....
  28. ncbi Synthesis and luminescent properties of the lanthanide isothiocyanate complexes with an amide-type tripodal ligand
    Kuan Zhen Tang
    State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China
    Spectrochim Acta A Mol Biomol Spectrosc 67:858-63. 2007
    ..At the same time, the luminescent properties of the Sm(III), Eu(III), Tb(III), Dy(III) isothiocyanate complexes in solid state and the Tb(III) complex in solvents were also investigated...
  29. ncbi Brilliant Sm, Eu, Tb, and Dy chiral lanthanide complexes with strong circularly polarized luminescence
    STEPHANE PETOUD
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    J Am Chem Soc 129:77-83. 2007
    ..The combination of high luminescence intensity with CPL activity should enable new bioanalytical applications of macromolecules in chiral environments...
  30. ncbi Facile construction of lanthanide metallomacrocycles with the bridging imidazolate and triazolate ligands and their ring expansions
    Jie Zhang
    Department of Chemistry, Fudan University, Shanghai 200433, People s Republic of China zhangjie fudan edu cn
    Inorg Chem 46:321-7. 2007
    ..All of these new complexes have been characterized by elemental analysis and spectroscopic properties, and their structures have also been determined through X-ray single-crystal diffraction analysis...
  31. ncbi Stepwise synthesis and magnetic control of trimetallic magnets [Co2Ln(L)2(H2O)4][Cr(CN)6].nH2O (Ln = La, Gd; H2L = 2,6-Di(acetoacetyl)pyridine) with 3-D pillared-layer structure
    Takuya Shiga
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan
    J Am Chem Soc 128:16426-7. 2006
    ..The overall magnetic nature can be systematically controlled by Ln(III) ions inserted between the 2-D ferromagnetic layers...
  32. ncbi From spherical to osmotically shrunken paramagnetic liposomes: an improved generation of LIPOCEST MRI agents with highly shifted water protons
    Enzo Terreno
    Dipartimento di Chimica I.F.M. and Centro di Imaging Molecolare, , Via P. Giuria 7, 10125 Torino, Italy
    Angew Chem Int Ed Engl 46:966-8. 2007
  33. ncbi Auto-assembling of ditopic macrocyclic lanthanide chelates with transition-metal ions. Rigid multimetallic high relaxivity contrast agents for magnetic resonance imaging
    Jérôme Paris
    Coordination and Radiochemistry, University of Liege, Sart Tilman B16, B 4000 Liege, Belgium
    Inorg Chem 45:5092-102. 2006
    ..The high relaxivity of the tris-PhenHDO3A lanthanide complexes is attributed to their internal rigidity...
  34. ncbi A novel strategy for the design of 8-hydroxyquinolinate-based lanthanide bioprobes that emit in the near infrared range
    Steve Comby
    Laboratory of Lanthanide Supramolecular Chemistry, Ecole Polytechnique Federale de Lausanne EPFL, BCH 1402, 1015 Lausanne, Switzerland
    Chemistry 13:936-44. 2007
    ..Finally, the same podate is shown to couple to human serum albumin, leading to an increase of 50 % in the NIR-luminescence intensity...
  35. ncbi Relationship between the ligand structure and the luminescent properties of water-soluble lanthanide complexes containing bis(bipyridine) anionic arms
    Loïc J Charbonnière
    Laboratoire de Chimie Moleculaire, UMR 7509 CNRS Ecole de Chimie, Polymères et Matériaux, 25 rue Becquerel, 67087 Strasbourg Cedex 02, France
    Chemistry 13:346-58. 2007
    ..The coordination behaviour of the series of ligands is questioned in the light of the spectroscopic data and discussed in terms of protection of the cation towards water molecules and their impact on the luminescence efficiency...
  36. ncbi Synthesis, characterization and luminescence property of N,N'-di(pyridine N-oxide-2-yl)pyridine-2,6-dicarboxamide and corresponding lanthanide (III) complexes
    Hai Jun Zhang
    College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China
    Spectrochim Acta A Mol Biomol Spectrosc 66:289-94. 2007
    ....
  37. ncbi Syntheses, structures, and properties of high-nuclear 3d-4f clusters with amino acid as ligand: {Gd6Cu24}, {Tb6Cu26}, and {(Ln6Cu24)2Cu} (Ln = Sm, Gd)
    Jian-jun Zhang
    State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, P. R. China
    Inorg Chem 45:7173-81. 2006
    ..The electrical conductivity measurements reveal that they are temperature-sensitive semiconductors. The magnetic susceptibility measurements display that compound 4 is ferromagnetic...
  38. ncbi Sensitized near-infrared lanthanide luminescence from Nd(III)- and Yb(III)-based cyclen-ruthenium coordination conjugates
    Katell Sénéchal-David
    School of Chemistry, Centre for Synthesis and Chemical Biology, University of Dublin, Trinity College Dublin, Dublin 2, Ireland
    Inorg Chem 45:10040-2. 2006
    ..Excitation of the Ru(II) metal-to-ligand charge-transfer band in water gave rise to long-wavelength sensitized emission from the Yb(III) or Nd(III) centers, observed in the near-infrared...
  39. ncbi A lanthanide phosphinidene complex: synthesis, structure, and phospha-Wittig reactivity
    Jason D Masuda
    Los Alamos National Laboratory, Mail Stop J514, Los Alamos, New Mexico 87545, USA
    J Am Chem Soc 130:2408-9. 2008
  40. ncbi Sensing the chirality of Dawson lanthanide polyoxometalates [alpha1-LnP2W17O61]7- by multinuclear NMR spectroscopy
    Cécile Boglio
    Laboratoire de chimie inorganique et materiaux moleculaires UMR CNRS 7071, Institut de Chimie Moleculaire FR 2769, Universite Pierre et Marie Curie Paris 6, Case Courrier 42, 4 place Jussieu, Paris Cedex 05, France
    Chemistry 14:1532-40. 2008
    ..N-Phosphonomethyl-L-proline appears to be a convenient ligand to promote separation of the diastereomers and ultimately resolution of the enantiomers of [alpha(1)-Yb(H(2)O)(4)P(2)W(17)O(61)](7-)...
  41. ncbi Molecular switching in the near infrared (NIR) to visible/NIR f-f emission with a functional-lanthanide complexes
    Ga Lai Law
    Department of Chemistry, The University of Hong Kong, Hong Kong, S A R, People s Republic of China
    J Fluoresc 18:749-52. 2008
    ....
  42. ncbi Synthesis of amidolanthanides with new chiral biaryl-based NNO ligands and their use as catalysts for enantioselective hydroamination/cyclization
    Qiuwen Wang
    Department of Chemistry, Beijing Normal University, Beijing 100875, China
    Inorg Chem 47:4319-28. 2008
    ..Complexes 6- 9 are active catalysts for the asymmetric hydroamination/cyclization of aminoalkenes, affording cyclic amines in good yields with moderate ee values...
  43. ncbi New 9- or 10-dentate luminescent lanthanide chelates
    Pinghua Ge
    Department of Physics and Center for Biophysics and Computational Biology, University of Illinois, Urbana, Illinois 61801, USA
    Bioconjug Chem 19:1105-11. 2008
    ..The TTHA-based chelate provides moderately good protection to the lanthanide ions...
  44. ncbi Experimental and theoretical comparison of actinide and lanthanide bonding in M[N(EPR(2))(2)](3) complexes (M = U, Pu, La, Ce; E = S, Se, Te; R = Ph, iPr, H)
    Andrew J Gaunt
    Chemistry Division and Associate Directorate for Chemistry, Life, and Earth Sciences, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Inorg Chem 47:29-41. 2008
    ..The fundamental and practical importance of such studies of the role of the valence d and f orbitals in the bonding of the f elements is emphasized...
  45. ncbi Syntheses, structures, and sensitized lanthanide luminescence by Pt --> Ln (Ln = Eu, Nd, Yb) energy transfer for heteronuclear PtLn2 and Pt2Ln4 complexes with a terpyridyl-functionalized alkynyl ligand
    Xiu Ling Li
    State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China
    Inorg Chem 46:10892-900. 2007
    ..Ln distances being ca. 14.2 A. The Pt --> Ln energy transfer rate (kET) is 6.07 x 10(7) s(-1) for Pt2Nd4 (6) and 2.12 x 10(5) s(-1) for Pt2Yb4 (9) species...
  46. ncbi Luminescent dinuclear lanthanide complexes of 5-Me-HXTA
    Louise S Natrajan
    Department of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, U K
    Inorg Chem 46:10877-86. 2007
    ..The terbium complex displays a high quantum yield of around 50% in aqueous solution with a low detection limit of 1 x 10(-12) M, rendering this compound a potential candidate for time-resolved applications...
  47. ncbi Synthesis, characterization of the luminescent lanthanide complexes with (Z)-4-(4-methoxyphenoxy)-4-oxobut-2-enoic acid
    Guo Jian Duan
    College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
    Spectrochim Acta A Mol Biomol Spectrosc 69:427-31. 2008
    ..The strong luminescence emitting peaks at 616nm for Eu(III) and 547nm for Tb(III) can be observed, which could be attributed to the ligand has an enhanced effect to the luminescence intensity of the Eu and Tb...
  48. ncbi Advances in structurally characterized lanthanide alkoxide, aryloxide, and silyloxide compounds
    Timothy J Boyle
    Sandia National Laboratories, Advanced Materials Laboratory, 1001 University Boulevard, S.E, Albuquerque, New Mexico 87106, USA
    Chem Rev 108:1896-917. 2008
  49. ncbi Emission detected circular dichroism from long-lived excited states: application to chiral Eu(III) systems
    Françoise C Muller
    Department of Chemistry, San Jose State University, San Jose, California
    Chirality 19:826-32. 2007
    ..The results are compared with conventional CD measurements, and additional characteristics and potential applications of EDCD are presented...
  50. ncbi A robust and convergent synthesis of dipeptide-DOTAM conjugates as chelators for lanthanide ions: new PARACEST MRI agents
    Filip Wojciechowski
    Department of Chemistry, The University of Western Ontario, London, Ontario, Canada N6A 5B7
    Bioconjug Chem 18:1625-36. 2007
    ..Extension of the synthetic approach to a wide variety of amino acids is possible...
  51. ncbi Rational tuning of melting entropies for designing luminescent lanthanide-containing thermotropic liquid crystals at room temperature
    Aude Escande
    Department of Inorganic, Analytical and Applied Chemistry, University of Geneva, 30 quai E Ansermet, 1211 Geneva 4, Switzerland
    Chemistry 13:8696-713. 2007
    ..Extension of the concept of chemical tuning of melting entropies for the global design of room-temperature metallomesogens and liquid crystals is discussed...
  52. ncbi Synthesis and structural properties of lanthanide complexes formed with tropolonate ligands
    Jian Zhang
    Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Inorg Chem 46:6473-82. 2007
    ..This analysis will aid us in optimizing ligand design for improved photophysical properties of the complex...
  53. ncbi Partial least-squares analysis of time decay data for Eu(III)-tetracycline complexes: simultaneous luminescent determination of tetracycline and oxytetracycline in bovine serum
    Gabriela A Ibañez
    Departamento de Quimica Analitica, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Suipacha 531, Rosario S2002LRK, Argentina
    Talanta 75:1028-34. 2008
    ..The results obtained by the developed method were statistically comparable to those obtained with high performance liquid chromatography...
  54. ncbi Complexation of trivalent lanthanide cations by erythritol in the solid state. The crystal structure and FT-IR study of 2EuCl3.2C4H10O4.7H2O
    Limin Yang
    The State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
    Carbohydr Res 339:1679-87. 2004
    ..The OH, CO stretching and other vibrations are shifted in the IR spectra of the complexes and the results are consistent with the crystal structure...
  55. ncbi A dodecalanthanide wheel supported by p-tert-butylsulfonylcalix[4]arene
    Takashi Kajiwara
    Department of Chemistry, Graduate School of Science, Tohoku University and CREST JST, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Chem Asian J 1:349-51. 2006
    ..The longest and shortest diameters of the core were estimated to be 17.7562(16) and 13.6810(13) A, respectively, and the saddle-shaped molecule possesses a pocketlike cavity inside...
  56. ncbi Photophysical properties of novel ternary lanthanide complexes with long chain mono-L cis-butene dicarboxylate (L = hexadecyl, octadecyl and eicosyl) and 2,2'-bipyridyl (or 1,10-phenanthroline)
    Bing Yan
    Department of Chemistry, Tongji University, Siping Road 1239, Shanghai 200092, China
    J Fluoresc 17:331-7. 2007
    ....
  57. ncbi Use of dipicolinate-based complexes for producing ion-imprinted polystyrene resins for the extraction of yttrium-90 and heavy lanthanide cations
    Anne-Sophie Chauvin
    Laboratory of Lanthanide Supramolecular Chemistry, , BCH 1402, 1015 Lausanne, Switzerland
    Chemistry 12:6852-64. 2006
    ....
  58. ncbi Detection strategies for bioassays based on luminescent lanthanide complexes and signal amplification
    Tanja Steinkamp
    Department of Chemical Analysis and MESA Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands
    Anal Bioanal Chem 380:24-30. 2004
    ..In this paper, the basic properties and major applications of both techniques are presented, and their future perspectives are discussed critically...
  59. ncbi Entropy-controlled solvolytic dissociation kinetics of lanthanide(III) complexes with polyaminocarboxylates in aqueous solutions
    S Saito
    Department of Applied Chemistry, Graduate School of Engineering, Tohoku University, Aoba, Sendai 980-8579, Japan
    Inorg Chem 40:3819-23. 2001
    ....
  60. ncbi Paramagnetic lanthanide(III) complexes as pH-sensitive chemical exchange saturation transfer (CEST) contrast agents for MRI applications
    Silvio Aime
    Dipartimento di Chimica I F M, Universita degli Studi di Torino, Torino, Italy
    Magn Reson Med 47:639-48. 2002
    ..40 ppm downfield H2O signal at 312K) and amide protons, respectively, produces a pH-dependent CEST effect which is the function of the concentration ratio of the two complexes...
  61. ncbi Solid-supported synthesis of polymerizable lanthanide-ion chelating lipids for protein detection
    Suad Nadi
    Department of Chemistry and Molecular Biology, North Dakota State University, Fargo, North Dakota 58105, USA
    Inorg Chem 44:2234-44. 2005
    ..We also demonstrate that the resulting polymerized liposomes (containing Eu3+) possess the appropriate luminescence properties for the qualitative and quantitative determination of proteins...
  62. ncbi Metal-switching and self-inclusion of functional cavitands
    Patrick Amrhein
    The Skaggs Institute for Chemical Biology and the Department of Chemistry, The Scripps Research Institute, MB-26, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 124:10349-58. 2002
    ..The lanthanide complexes of octaphosphonates 5 in methanol-d(4) are velcraplex-like dimers held together by four metal cations...
  63. ncbi Structural, luminescence, and NMR studies of the reversible binding of acetate, lactate, citrate, and selected amino acids to chiral diaqua ytterbium, gadolinium, and europium complexes
    Rachel S Dickins
    Department of Chemistry, University of Durham, South Road, UK
    J Am Chem Soc 124:12697-705. 2002
    ..Crystal structures of the Gly and Ser adducts confirm this. In peptides and proteins (e.g. albumin) containing Glu or Asp residues, the more basic side chain carboxylate may chelate to the Ln ion, displacing both waters...
  64. ncbi Synthesis of metal-chelating lipids to sensitize lanthanide ions
    Bidhan C Roy
    Department of Chemistry, North Dakota State University, Fargo 58105, USA
    J Org Chem 68:3999-4007. 2003
    ..Liposomes from the lipid 18-Eu(3+) provided a probe that relies not only on the emission wavelengths of Eu(3+) but also on a reproducible lifetime that can be used for protein identification...
  65. ncbi Enhanced lanthanide luminescence using silver nanostructures: opportunities for a new class of probes with exceptional spectral characteristics
    Meng Wu
    Center for Fluorescence Spectroscopy, Department of Biochemistry, and Molecular Biology, Medical Biotechnology Center, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    J Fluoresc 15:53-9. 2005
    ....
  66. ncbi Synthesis of a bifunctional monophosphinic acid DOTA analogue ligand and its lanthanide(III) complexes. A gadolinium(III) complex endowed with an optimal water exchange rate for MRI applications
    Jakub Rudovský
    Department of Inorganic Chemistry, Universita Karlova, Hlavova 2030, 128 40, Prague 2, Czech Republic
    Org Biomol Chem 3:112-7. 2005
    ..These results prompt the use of [Gd(H2O)(DO3APABn)]- as a building block for the set-up of highly efficient macromolecular MRI contrast agents...
  67. ncbi Chelating bis(thiophosphinic amidate)s as versatile supporting ligands for the group 3 metals. An application to the synthesis of highly active catalysts for intramolecular alkene hydroamination
    Young Kwan Kim
    Department of Chemistry, Montana State University, Bozeman, Montana 59717, USA
    J Am Chem Soc 125:9560-1. 2003
    ..These unusual pentacoordinate complexes exhibit very high activity as catalysts for intramolecular alkene hydroamination...
  68. ncbi Lanthanide/ATP interaction in water mediated by luminescent hemispherical-shaped complexes
    Samir Mameri
    LCM, ECPM, 25 rue Becquerel, 67087 Strasbourg Cedex 02, France
    Inorg Chem 43:1819-21. 2004
    ..0. The interaction of these anions with the complex was investigated by means of absorption and emission spectroscopies. With ATP(4)(-), ES-MS and (31)P NMR experiments revealed the formation of a [Ln.L.(ATP)](3)(-) ternary species...
  69. ncbi Stable lanthanide luminescence agents highly emissive in aqueous solution: multidentate 2-hydroxyisophthalamide complexes of Sm(3+), Eu(3+), Tb(3+), Dy(3+)
    STEPHANE PETOUD
    Department of Chemistry, University of California, Berkeley, California 94720 1460, USA
    J Am Chem Soc 125:13324-5. 2003
    ..The low overlap of the four different Ln complexes enables their simultaneous detection and discrimination...
  70. ncbi A novel series of complexones with bis- or biazole structure as mixed ligands of paramagnetic contrast agents for MRI
    Elena P Mayoral
    , Facultad de Ciencias, UNED, Senda del Rey 9, 28040 Madrid, Spain
    Bioorg Med Chem 11:5555-67. 2003
    ..2, 5.6) or Gd(III)DTPA (4.30, 4.30). These improvements involve mainly increased hydration and slower rotational motions. In vitro toxicity experiments are reported...
  71. ncbi Polymetallic lanthanide complexes with PAMAM-naphthalimide dendritic ligands: luminescent lanthanide complexes formed in solution
    Jason P Cross
    Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Am Chem Soc 126:16278-9. 2004
    ..0006, the good protection of the eight lanthanide cations bound in the dendrimer structure and the high absorptivity leads to the red emission from Eu3+ that is easily observed in solution under irradiation with 354 nm UV light...
  72. ncbi Lanthanide spectroscopic studies of the dinuclear and Mg(II)-dependent PvuII restriction endonuclease
    Lori M Bowen
    Department of Chemistry and Biochemistry, University of Missouri St. Louis, St. Louis, Missouri 63121, USA
    Biochemistry 43:15286-95. 2004
    ....
  73. ncbi Syntheses, crystal structures, and luminescent properties of novel layered lanthanide sulfonate-phosphonates
    Jun-Ling Song
    State Key Laboratory of Structure Chemistry, Fujian Institute of Research on the Structure of Matter, The Chinese Academy of Sciences, Fuzhou 350002, P. R. China
    Inorg Chem 43:5630-4. 2004
    ..The luminescent properties of compounds 3 and 4 have also been studied...
  74. ncbi An efficient design for the rigid assembly of four bidentate chromophores in water-stable highly luminescent lanthanide complexes
    Nicholas Chatterton
    Laboratoire de Chimie Inorganique et Biologique (UMR-E 3 CEA-UJF, , CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble, Cedex 09, France
    Angew Chem Int Ed Engl 44:7595-8. 2005
  75. ncbi Syntheses, structures, near-infrared and visible luminescence, and magnetic properties of lanthanide-organic frameworks with an imidazole-containing flexible ligand
    Zheng-Hua Zhang
    Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China
    Inorg Chem 45:2896-902. 2006
    ..8 k...
  76. ncbi Stable 8-hydroxyquinolinate-based podates as efficient sensitizers of lanthanide near-infrared luminescence
    Steve Comby
    Laboratory of Lanthanide Supramolecular Chemistry, , BCH 1402, CH-1015 Lausanne, Switzerland
    Inorg Chem 45:732-43. 2006
    ..04% and = 0.37%). In fact, TsoxMe yields one of the most luminescent Yb(III) compounds known in water, and this ligand appears to be suitable for the development of NIR probes for bioanalyses...
  77. ncbi Lanthanide complexes of a picolinate ligand derived from 1,4,7-triazacyclononane with potential application in magnetic resonance imaging and time-resolved luminescence imaging
    Aline Nonat
    Laboratoire de Reconnaissance Ionique, Service de Chimie Inorganique et Biologique (UMR-E 3 CEA-UJF, , CEA-Grenoble, 38054 Grenoble Cedex 09, France
    Chemistry 12:7133-50. 2006
    ..The optimisation of the electronic relaxation by ligand design is especially important to achieve high relaxivity in the new generation macromolecular complexes with long rotational correlation times...
  78. ncbi Solution and structural investigations of ligand preorganization in trivalent lanthanide complexes of bicyclic malonamides
    Bevin W Parks
    Chemistry Department, University of Oregon, Eugene, 97403-1253, USA
    Inorg Chem 45:1498-507. 2006
    ..These results support the conclusion that rational ligand design can lead to compounds that enhance the binding affinities within a ligand class...
  79. ncbi Heterometallic Ln/Hg compounds with fluorinated thiolate ligands
    Santanu Banerjee
    Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854-8087, USA
    Inorg Chem 43:6307-12. 2004
    ....
  80. ncbi Tuning the decay time of lanthanide-based near infrared luminescence from micro- to milliseconds through d-->f energy transfer in discrete heterobimetallic complexes
    Stéphane Torelli
    Department of Inorganic, Analytical and Applied Chemistry, University of Geneva, 30 quai E Ansermet, 1211 Geneva 4, Switzerland
    Chemistry 11:3228-42. 2005
    ..The origin of this effect, together with its rational control for programming optical functions in discrete heterobimetallic entities, are discussed...
  81. ncbi Photophysical approaches to responsive optical probes
    Clémence Allain
    University of Oxford, Chemistry Research Laboratory, Oxford OX1 3TA, UK
    Future Med Chem 2:339-50. 2010
    ....
  82. ncbi Critical in vitro evaluation of responsive MRI contrast agents for calcium and zinc
    Anurag Mishra
    Department of Chemistry, Durham University, South Road, Durham, DH1 3LE UK
    Chemistry 17:1529-37. 2011
    ..Such systems may, therefore, be considered for use as magnetic resonance imaging (MRI) contrast agents to track the restoration of changes in metal-ion concentration in the cerebrospinal fluid of the brain, following neural stimulation...
  83. ncbi Near-infrared luminescence from visible-light-sensitized hybrid materials covalently linked with tris(8-hydroxyquinolinate)-lanthanide [Er(III), Nd(III), and Yb(III)] derivatives
    Lining Sun
    Research Center of Nano Science and Technology, Shanghai University, Shanghai 200444, People s Republic of China
    J Phys Chem B 114:16393-7. 2010
    ..The good luminescent performances enable these NIR-luminescent xerogel materials to have possible applications in medical diagnostics, laser systems, and optics, etc...
  84. ncbi Lanthanide dota-like complexes containing a picolinate pendant: structural entry for the design of Ln(III)-based luminescent probes
    Martín Regueiro-Figueroa
    Departamento de Química Fundamental, Universidade da Coruña, Campus da Zapateira Rúa da Fraga 10, 15008 A Coruña, Spain
    Inorg Chem 50:4125-41. 2011
    ..However, these rates are 1-2 orders of magnitude lower than those of do3a analogues, which shows that the complexes reported herein are remarkably inert with respect to metal ion dissociation...
  85. ncbi Lanthanide complexes as imaging agents anchored on nano-sized particles of boehmite
    Estefanía Delgado-Pinar
    Instituto de Ciencia Molecular ICMOL, Departamento de Quimica Inorganica, Universidad de Valencia, Edificio de Institutos de Paterna, C Catedrático José Beltrán 2, Apartado de Correos 22085, 46071, Valencia, Spain
    Dalton Trans 40:6451-7. 2011
    ..This platform could represent an alternative to silica-based inert matrices as imaging vehicles...
  86. ncbi Distribution of the lanthanides in the earth's crust
    Stuart Ross Taylor
    Department of Geology, Australian National University, Canberra, Australia 0200
    Met Ions Biol Syst 40:1-38. 2003
  87. ncbi Site-specific free energy changes in proteins upon ligand binding by nuclear magnetic resonance: Ca2+ -displacement by Ln3+ in a Ca2+ -binding protein from Entamoeba histolytica
    Kousik Chandra
    Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai, India
    Chem Biol Drug Des 77:272-80. 2011
    ..In this communication, we set out to use such information to derive the associated microscopic binding constants...
  88. ncbi Cleavage of double stranded plasmid DNA by lanthanide complexes
    Bohuslav Rittich
    Department of Microbiology, Faculty of Science, Masaryk University Brno, Tvrdeho 14, CZ 602 00 Brno, Czech Republic
    J Chromatogr B Analyt Technol Biomed Life Sci 800:169-73. 2004
    ..The temperature of reaction mixture had substantial influence on cleavage rate. The precipitation of DNA occurred during the measurement of interactions between chromosomal DNA and La(3+) ions...
  89. ncbi Chondrules with peculiar REE patterns: implications for solar nebular condensation at high C/O
    Andreas Pack
    Institut für Mineralogie und Geochemie, Universitat Koln, Zülpicher Strasse 49b, D 50674 Köln, Germany
    Science 303:997-1000. 2004
    ..This interpretation implies that high-temperature condensation processes occurred in nebular environments with a strong deficit in oxygen, such as regions with an enhanced carbon/oxygen ratio...
  90. ncbi Enantioselective resolutions and circular dichroism studies of lanthanide-containing Keggin-type [Ln(PW11O39)2](11-) polyoxometalates
    Haruo Naruke
    Chemical Resources Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta, Yokohama 226 8503, Japan
    Inorg Chem 50:7535-9. 2011
    ..Chirality inductions by l- and d-pro from a racemic solution of [Er(PW(11)O(39))(2)](11-) was demonstrated by means of CD spectroscopy...
  91. ncbi Lanthanide coordination polymers and their Ag+-modulated fluorescence
    Weisheng Liu
    Department of Chemistry and National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China
    J Am Chem Soc 126:2280-1. 2004
    ..The structure of the Gd(III) complex was characterized. The fluorescence of the Eu(III) complex can be modulated by Ag+...
  92. ncbi Unprecedented near-infrared (NIR) emission in diplatinum(III) (d7-d7) complexes at room temperature
    Martin A Bennett
    Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia
    J Am Chem Soc 132:7094-103. 2010
    ....
  93. ncbi La(3+), Gd(3+) and Yb(3+) induced changes in mitochondrial structure, membrane permeability, cytochrome c release and intracellular ROS level
    Huixue Liu
    Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Chem Biol Interact 146:27-37. 2003
    ..In parallel with these events, there was a higher level of ROS found in the cells exposed to Ln. It was proposed that Ln-induced apoptosis via the MT pathways and it was highly possible that ROS were involved in the mechanism...
  94. ncbi New lanthanide complexes with antioxidant activity
    Irena Kostova
    Department of Chemistry, Faculty of Pharmacy, Medical University, Sofia, Bulgaria
    Med Chem 4:371-8. 2008
    ..The results obtained indicate that the tested compounds exerted a considerable antioxidant effect upon the evaluated radicals' formation in the blood plasma of Wistar rat...
  95. ncbi Tunable paramagnetic relaxation enhancements by [Gd(DPA)(3)] (3-) for protein structure analysis
    Hiromasa Yagi
    Research School of Chemistry, Australian National University, Canberra, ACT, 0200, Australia
    J Biomol NMR 47:143-53. 2010
    ..As an example we studied the quaternary structure of the homodimeric GCN4 leucine zipper...
  96. ncbi Investigation of the structural properties of an extended series of lanthanide bis-hydroxychlorides Ln(OH)(2)Cl (Ln = Nd-Lu, except Pm and Sm)
    Ralph A Zehnder
    Department of Chemistry, University of Louisiana at Monroe, Monroe, Louisiana 71209, USA
    Inorg Chem 49:4781-90. 2010
    ..It is expected that the analogue actinide bis-hydroxychlorides exhibit similar behavior and that this may have important implications in the immobilization and safe disposal of nuclear waste...
  97. ncbi An NMR and DFT investigation on the conformational properties of lanthanide(III) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate analogues containing methylenephosphonate pendant arms
    Mihály Purgel
    Department of Inorganic and Analytical Chemistry, University of Debrecen, P O Box 21, Egyetem ter 1, Debrecen H 4010, Hungary
    Inorg Chem 49:4370-82. 2010
    ....
  98. ncbi Mechanism of ionic recognition by polymer-supported reagents: immobilized tetramethylmalonamide and the complexation of lanthanide ions
    Yijia Yang
    Department of Chemistry, Hunter College of the City University of New York, 695 Park Avenue, New York, New York 10065, USA
    Inorg Chem 49:1008-16. 2010
    ..A comparison of the distribution coefficients at the maxima (6 M HCl and 4 M HNO(3)) shows nitrate to have greater values than chloride due to a hydration effect, as also indicated by results from H(2)SO(4)...
  99. ncbi Construction of 1-D 4f and 3d-4f coordination polymers with flexible Schiff base ligands
    Xiaoping Yang
    Department of Chemistry and Biochemistry, The University of Texas at Austin, 78712 0165, USA
    Dalton Trans 40:9795-801. 2011
    ..The structures of 1-4 were determined by single crystal X-ray crystallographic studies and their luminescence properties in MeCN solution were determined...
  100. ncbi Synthesis and characterization of dinuclear heterometallic lanthanide complexes exhibiting MRI and luminescence response
    Ilgar Mamedov
    Department for Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Spemannstr 38, 72076, Tubingen, Germany
    Dalton Trans 39:5721-7. 2010
    ..They show the dominance of a q = 1 species for both ions in monometallic complexes, or q = 1 and q = 2 species of ions in aggregated complexes, for DOTA and 5A-PADDTA chelators, respectively...
  101. ncbi DOTA-M8: An extremely rigid, high-affinity lanthanide chelating tag for PCS NMR spectroscopy
    Daniel Haussinger
    Department of Chemistry, University of Basel, St Johanns Ring 19, 4056 Basel, Switzerland
    J Am Chem Soc 131:14761-7. 2009
    ....

Research Grants73

  1. Flourescent Ceramic Nanoprobes (RMI)
    TIMOTHY BOYLE; Fiscal Year: 2007
    ..All of the innovations uncovered during the preparation of these nanoprobes will be shared in order to benefit medical research applications beyond those proposed in this investigation. ..
  2. Microarrays for DNA binding proteins
    Tomasz Heyduk; Fiscal Year: 2006
    ..In diagnosis, they will provide an opportunity to develop new disease detection tools which will identify disease through a specific pattern of transcription factor activities characteristic for a particular disease. ..
  3. INTER & INTRAMOLECULAR COMMUNICATIONS IN TRANSCRIPTION
    Tomasz Heyduk; Fiscal Year: 2006
    ..It is expected that a detailed understanding of the role of several protein-protein and protein-DNA contacts in RNA polymerase function will be obtained. ..
  4. STRUCTURAL AND MECHANISTIC STUDIES OF PHOSPHONATASE
    Karen Allen; Fiscal Year: 2005
    ..The goal of these studies is to derive an understanding of how the enzyme superfamily active site has been adapted to catalyze C-X, P-O and C-P bond cleavage in a variety of different substrate structures. ..
  5. MOLECULAR BEACONS FOR PROTEIN DETECTION
    Tomasz Heyduk; Fiscal Year: 2005
    ..abstract_text> ..
  6. INTER AND INTRAMOLECULAR COMMUNICATIONS IN TRANSCRIPTION
    Tomasz Heyduk; Fiscal Year: 2010
    ..Such information will enable development of new antibiotics targeting bacterial RNA polymerase. Development of new antibiotics targeting new targets is essential to combating emerging antibiotic-resistant strains. ..
  7. STRUCTURAL DYNAMICS OF ACTIN AND MYOSIN INTERACTIONS
    DOUGLAS ROOT; Fiscal Year: 2005
    ..Recent progress being made toward achieving such an understanding of this critical process in motility and the proposed research will contribute to this effort. ..
  8. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2005
    ..4) Carbometalation/cyclization reactions will be explored utilizing organochromium species. 5) Ligands and catalytic systems designed for asymmetric synthesis will be explored. ..
  9. Mechanisms and Function in HAD Phosphotransferases
    Karen Allen; Fiscal Year: 2007
    ....
  10. PROGRAM IN MOLECULAR AND COMPUTATIONAL BIOPHYSICS
    David Draper; Fiscal Year: 2007
    ....
  11. Coupling Reactions-Methods Development and Applications
    GARY MOLANDER; Fiscal Year: 2007
    ..These types of transformations are anticipated to have broad generality and will thus prove valuable for the rapid, efficient, and unique assembly of complex organic molecules throughout the pharmaceutical industry and beyond. ..
  12. Organotrifluoroborates in Selective Organic Synthesis
    Gary A Molander; Fiscal Year: 2010
    ..In this way, new drug entities can be delivered to the public more rapidly and efficiently at lower cost. ..
  13. Mechanisms and Function in HAD Phosphotransferases
    Karen Allen; Fiscal Year: 2009
    ..abstract_text> ..
  14. FACTORS STABILIZING RNA STRUCTURES
    David Draper; Fiscal Year: 2009
    ..Drugs which stabilize or alter specific critical RNA structures could have wide therapeutical applications. An understanding of the forces that stabilize RNA structures could aid in selection of drug targets and the design of new drugs. ..
  15. Coupling Reactions-Methods Development and Applications
    GARY MOLANDER; Fiscal Year: 2007
    ..abstract_text> ..
  16. Nogo's role in intracellular trafficking
    Noam Harel; Fiscal Year: 2007
    ....
  17. Portable Analyzer for On-site Monitoring of Worker Exposure to Toxic Metals
    Charles Timchalk; Fiscal Year: 2007
    ..Ultimately, the sensor for metal ions will be combined with the sensor for creatinine so that the exposure monitoring can be performed with "spot" urine instead of 24-hr urine. ..
  18. INTER AND INTRAMOLECULAR COMMUNICATIONS IN TRANSCRIPTION
    Tomasz Heyduk; Fiscal Year: 2002
    ..The applicant hopes to identify critical determinants of initial promoter recognition and productive elongation, complex formation. ..
  19. INTRAMOLECULAR REDUCTIVE COUPLING REACTIONS
    GARY MOLANDER; Fiscal Year: 2003
    ..The study of the mechanism of action of GPI-anchoring inhibitors may lead to therapies for parasitic protozoan infections. ..
  20. FACTORS STABILIZING RNA STRUCTURES
    David Draper; Fiscal Year: 2002
    ..This information will fill in a crucial aspect of non-canonical and tertiary RNA folding energetics. ..
  21. CATALYTIC PROCESSES FOR SELECTIVE ORGANIC SYTHESIS
    GARY MOLANDER; Fiscal Year: 2002
    ..4) Cyclization reactions of polyolefins, dieneynes, enediynes, etc. involving sequential reactions wherein the cyclizations are terminated by silylation, boration, hydrogenolysis, or beta-hydride elimination. ..
  22. FACTORS STABILIZING RNA STRUCTURES
    David Draper; Fiscal Year: 2006
    ..The ability to predict the Mg2+-dependent folding free energies of RNA tertiary conformations would be useful in a number of contexts. ..
  23. Frequency Shifting Paramagnetic Agents: Quantitative MRI of Exchange Effects
    Elena Vinogradov; Fiscal Year: 2007
    ..We propose to develop such a paradigm starting from the basic theoretical model all the way through to successful quantitative detection in-vivo. ..
  24. RIBOSOMAL PROTEIN S4 INTERACTIONS WITH MRNA AND RRNA
    David Draper; Fiscal Year: 2001
    ..Results from these studies should contribute to a basic understanding of protein-RNA recognition mechanisms and RNA folding, as well as elucidation of specific S4 roles in translational regulation and ribosome assembly. ..