Genomes and Genes
Summary: A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Publications294 found, 100 shown here
- Zinc in human health: effect of zinc on immune cellsAnanda S Prasad
Wayne State University School of Medicine, Detroit, Michigan 48201, United States of America
Mol Med 14:353-7. 2008Although the essentiality of zinc for plants and animals has been known for many decades, the essentiality of zinc for humans was recognized only 40 years ago in the Middle East...
- Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's diseaseJames A Duce
Mental Health Research Institute, The University of Melbourne, Parkville, Victoria 3052, Australia
Cell 142:857-67. 2010..Abnormal exchange of cortical zinc may link amyloid pathology with neuronal iron accumulation in AD.
- Metallo-beta-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamilyCarine Bebrone
Center for Protein Engineering Biological Macromolecules, University of Liege, Allée du 6 Août B6, Sart Tilman 4000 Liège, Belgium
Biochem Pharmacol 74:1686-701. 2007..In the last few years, many new zinc beta-lactamases have been described and several pathogens are now known to synthesize members of this class...
- Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasisC E Outten
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
Science 292:2488-92. 2001Intracellular zinc is thought to be available in a cytosolic pool of free or loosely bound Zn(II) ions in the micromolar to picomolar range...
- Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial AbetaPaul A Adlard
Oxidation Biology Laboratory, The Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia
Neuron 59:43-55. 2008..The speed of recovery of the animals underscores the acutely reversible nature of the cognitive deficits associated with transgenic models of AD...
- Zinc in the physiology and pathology of the CNSStefano L Sensi
Department of Basic and Applied Medical Science, Molecular Neurology Unit, CeSI Center for Excellence on Aging, University G dAnnunzio, Chieti, 66013, Italy
Nat Rev Neurosci 10:780-91. 2009The past few years have witnessed dramatic progress on all frontiers of zinc neurobiology...
- Mammalian zinc transporters: nutritional and physiologic regulationLouis A Lichten
Nutritional Genomics Laboratory, Food Science and Human Nutrition Department and Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611 2710, USA
Annu Rev Nutr 29:153-76. 2009Research advances defining how zinc is transported into and out of cells and organelles have increased exponentially within the past five years...
- Low micromolar zinc accelerates the fibrillization of human tau via bridging of Cys-291 and Cys-322Zhong Ying Mo
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
J Biol Chem 284:34648-57. 2009..There is considerable evidence showing that zinc, as an essential element that is highly concentrated in brain, is linked to the development or progression of these ..
- Zinc coordination sphere in biochemical zinc sitesD S Auld
Center for Biochemical and Biophysical Sciences and Medicine and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Biometals 14:271-313. 2001b>Zinc is known to be indispensable to growth and development and transmission of the genetic message. It does this through a remarkable mosaic of zinc binding motifs that orchestrate all aspects of metabolism...
- Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidenceJian Dong
Department of Biochemistry, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
Biochemistry 42:2768-73. 2003..The results also reveal a direct chemical basis for oxidative damage caused by amyloid-beta protein in AD...
- Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variantsTamara J Nicolson
Section of Cell Biology, Division of Medicine, Imperial College London, London, U K
Diabetes 58:2070-83. 2009b>Zinc ions are essential for the formation of hexameric insulin and hormone crystallization...
- Zinc finger proteins: new insights into structural and functional diversityJ H Laity
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Curr Opin Struct Biol 11:39-46. 2001b>Zinc finger proteins are among the most abundant proteins in eukaryotic genomes...
- Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturationAndreas M Grabrucker
Institute of Anatomy and Cell Biology, University of Ulm, Ulm, Germany
EMBO J 30:569-81. 2011..postsynapses and comparing this to shRNA-mediated knockdown, we could demonstrate that only the overexpression of zinc-sensitive ProSAP1/Shank2 or ProSAP2/Shank3 leads to increased synapse density, although all of them cause a ..
- Zinc is a novel intracellular second messengerSatoru Yamasaki
Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan
J Cell Biol 177:637-45. 2007b>Zinc is an essential trace element required for enzymatic activity and for maintaining the conformation of many transcription factors; thus, zinc homeostasis is tightly regulated...
- Roles of zinc and zinc signaling in immunity: zinc as an intracellular signaling moleculeToshio Hirano
Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
Adv Immunol 97:149-76. 2008b>Zinc (Zn) is an essential nutrient required for cell growth, differentiation, and survival, and its deficiency causes growth retardation, immunodeficiency, and other health problems...
- Preventive zinc supplementation among infants, preschoolers, and older prepubertal childrenKenneth H Brown
Department of Nutrition, University of California, Davis, California 95616, USA
Food Nutr Bull 30:S12-40. 2009b>Zinc supplementation trials carried out among children have produced variable results, depending on the specific outcomes considered and the initial characteristics of the children who were enrolled...
- Zinc ions promote Alzheimer Abeta aggregation via population shift of polymorphic statesYifat Miller
Center for Cancer Research Nanobiology Program, National Cancer Institute Frederick, Frederick, MD 21702, USA
Proc Natl Acad Sci U S A 107:9490-5. 2010..factor in Alzheimer's disease etiology is enrichment of Zn(2+) in aggregates, and there are data suggesting that zinc promotes aggregation, how Zn(2+)-Abeta coordination promotes aggregation is elusive...
- Contributions of Zur-controlled ribosomal proteins to growth under zinc starvation conditionsScott E Gabriel
Department of Microbiology, Cornell University, Ithaca, NY 14853 8101, USA
J Bacteriol 191:6116-22. 2009Maintaining intracellular zinc levels is critical, because zinc serves as a cofactor for many required enzymes and is toxic in excess...
- A fungal family of transcriptional regulators: the zinc cluster proteinsSarah MacPherson
Department of Microbiology and Immunology, Royal Victoria Hospital, McGill University, , , Canada H3A 1A
Microbiol Mol Biol Rev 70:583-604. 2006The trace element zinc is required for proper functioning of a large number of proteins, including various enzymes. However, most zinc-containing proteins are transcription factors capable of binding DNA and are named zinc finger proteins...
- Synaptically released zinc triggers metabotropic signaling via a zinc-sensing receptor in the hippocampusLimor Besser
Department of Morphology, Ben Gurion University, Beer Sheva 84105, Israel
J Neurosci 29:2890-901. 2009..Our results describe a unique role for synaptic Zn(2+) acting as the physiological ligand of a metabotropic receptor and provide a novel pathway by which synaptic Zn(2+) can regulate neuronal function...
- The ZnuABC high-affinity zinc uptake system and its regulator Zur in Escherichia coliS I Patzer
Mikrobiologie Membranphysiologie, Universitat Tubingen, Germany
Mol Microbiol 28:1199-210. 1998..This high-affinity transport was energized by ATP. The genes were named znuACB (for zinc uptake; former name yebLMI) and localized at 42 min on the genetic map of E. coli...
- A comparison of the Thlaspi caerulescens and Thlaspi arvense shoot transcriptomesJohn P Hammond
Warwick HRI, University of Warwick, Wellesbourne, Warwick CV35 9EF, UK
New Phytol 170:239-60. 2006..of a robust method to profile and compare the transcriptomes of two nonmodel plant species, Thlaspi caerulescens, a zinc (Zn) hyperaccumulator, and Thlaspi arvense, a nonhyperaccumulator, using Affymetrix Arabidopsis thaliana ATH1-..
- The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitationH Zhao
Department of Biochemistry and Molecular Biology, School of Medicine, University of Minnesota, Duluth 55812, USA
Proc Natl Acad Sci U S A 93:2454-8. 1996The yeast Saccharomyces cerevisiae has two separate systems for zinc uptake. One system has high affinity for substrate and is induced in zinc-deficient cells...
- Regulation of T cell receptor signaling by activation-induced zinc influxMingcan Yu
Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
J Exp Med 208:775-85. 2011b>Zinc is a trace element that is essential for innate and adaptive immune responses. In addition to being a structural element of many proteins, zinc also functions as a neurotransmitter and an intracellular messenger...
- A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapsesAtul Deshpande
Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697, USA
J Neurosci 29:4004-15. 2009..The zinc-binding 8-OH-quinoline clioquinol markedly reduced AbetaO synaptic targeting, which was also reduced in brain ..
- The essential toxin: impact of zinc on human healthLaura M Plum
Institute of Immunology, Medical Faculty, RWTH Aachen University, Pauwelstrasse 30, 52074 Aachen, Germany
Int J Environ Res Public Health 7:1342-65. 2010Compared to several other metal ions with similar chemical properties, zinc is relatively harmless. Only exposure to high doses has toxic effects, making acute zinc intoxication a rare event...
- Zinc supplement greatly improves the condition of parkin mutant DrosophilaNidhi Saini
Institute of Molecular Life Sciences, University of Zurich, Switzerland
Biol Chem 391:513-8. 2010..In a Drosophila disease model lacking Parkin (park(25) null mutant), we tested the effect of zinc supplementation. Zinc is an essential trace metal and a component of many enzymes and transcriptional regulators...
- The adaptive response to dietary zinc in mice involves the differential cellular localization and zinc regulation of the zinc transporters ZIP4 and ZIP5Jodi Dufner-Beattie
Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160 7421, USA
J Biol Chem 279:49082-90. 2004The ZIP5 gene encodes a protein closely related to ZIP4, a zinc transporter mutated in the human genetic disorder acrodermatitis enteropathica...
- Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4Marc Hanikenne
Max Planck Institute of Molecular Plant Physiology, D 14476 Potsdam, Germany
Nature 453:391-5. 2008..A. halleri naturally accumulates and tolerates leaf concentrations as high as 2.2% zinc and 0.28% cadmium in dry biomass. On the basis of transcriptomics studies, metal hyperaccumulation in A...
- Zinc enhances long-term potentiation through P2X receptor modulation in the hippocampal CA1 regionRamón A Lorca
Laboratorio de Neurociencias, Departamento de Biologia, Facultad de Quimica y Biologia, Universidad de Santiago de Chile, Santiago 9170022, Chile
Eur J Neurosci 33:1175-85. 2011..Although it is not yet clear which purinergic receptor subtype(s) is responsible for these effects on LTP, the data presented here suggest that P2X₄ but not P2X₇ is involved...
- Intracellular zinc homeostasis and zinc signalingMasaaki Murakami
Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
Cancer Sci 99:1515-22. 2008b>Zinc (Zn) is an essential heavy metal that is incorporated into a number of human Zn metalloproteins. Zn plays important roles in nucleic acid metabolism, cell replication, and tissue repair and growth...
- Nerve growth factor in different crystal forms displays structural flexibility and reveals zinc binding sitesD R Holland
Institute of Molecular Biology, Howard Hughes Medical Institute, Eugene, OR
J Mol Biol 239:385-400. 1994..1) with zinc acetate concentrations of 1 mM and 100 mM, respectively...
- The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in miceJodi Dufner-Beattie
Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160 7421, USA
J Biol Chem 278:33474-81. 2003The human ZIP4 gene (SLC39A4) is a candidate for the genetic disorder of zinc metabolism acrodermatitis enteropathica. To understand its role in zinc homeostasis, we examined the function and expression of mouse ZIP4...
- Characterization of a Mycobacterium tuberculosis ESX-3 conditional mutant: essentiality and rescue by iron and zincAgnese Serafini
Department of Histology, Microbiology, and Medical Biotechnologies, University of Padua, Via Gabelli 63, 35121 Padua, Italy
J Bacteriol 191:6340-4. 2009..bovis BCG attenuation. Another T7SS, ESX-3, has been previously shown to be transcriptionally controlled by the zinc uptake repressor (Zur) and by the iron-dependent transcriptional repressor (IdeR), suggesting that it might be ..
- Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction but not the immediate-type reactionKeigo Nishida
Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
J Exp Med 206:1351-64. 2009b>Zinc (Zn) is an essential nutrient and its deficiency causes immunodeficiency. However, it remains unknown how Zn homeostasis is regulated in mast cells and if Zn transporters are involved in allergic reactions...
- Transient fluctuations of intracellular zinc ions in cell proliferationYuan Li
Division of Human Nutrition, Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555, USA
Exp Cell Res 315:2463-70. 2009b>Zinc is essential for cell proliferation, differentiation, and viability. When zinc becomes limited for cultured cells, DNA synthesis ceases and the cell cycle is arrested...
- Zinc deficiency induces depression-like symptoms in adult ratsNadine M Tassabehji
Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, Florida 32306 4340, United States
Physiol Behav 95:365-9. 2008There is mounting evidence suggesting a link between serum zinc levels and clinical depression...
- Zinc salts inactivate clinical isolates of herpes simplex virus in vitroM Arens
The Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Clin Microbiol 38:1758-62. 2000Using a standard plaque assay and clinical isolates of herpes simplex virus (HSV), we have tested the ability of zinc salts to inactivate HSV...
- Zap1p, a metalloregulatory protein involved in zinc-responsive transcriptional regulation in Saccharomyces cerevisiaeH Zhao
Department of Biochemistry and Molecular Biology, University of Minnesota Duluth, 55812, USA
Mol Cell Biol 17:5044-52. 1997b>Zinc ion homeostasis in Saccharomyces cerevisiae is controlled primarily through the transcriptional regulation of zinc uptake systems in response to intracellular zinc levels...
- Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 years in an urban, low-income population in Bangladesh: randomised controlled trialW Abdullah Brooks
The Centre for Health and Population Research, International Centre for Diarrhoea Disease Research, Mohakhali Dhaka 1000, Bangladesh
Lancet 366:999-1004. 2005..Most deaths occur during infancy and in developing countries. Daily regimens of zinc have been reported to prevent acute lower respiratory tract infection and diarrhoea, and to reduce child mortality...
- The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertilityI M W Ebisch
Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Hum Reprod Update 13:163-74. 2007..b>Zinc has also been implicated in testicular development, sperm maturation and testosterone synthesis...
- Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14K M Taylor
Tenovus Cancer Research Centre, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3XF, UK
FEBS Lett 579:427-32. 2005Here, we report the first investigation of a novel member of the LZT (LIV-1 subfamily of ZIP zinc Transporters) subfamily of zinc influx transporters...
- Antidepressant-like properties of zinc in rodent forced swim testB Kroczka
Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
Brain Res Bull 55:297-300. 2001The effects of zinc, the N-methyl-D-aspartate glutamate receptor inhibitor, were studied in mice and rats using the forced swim test...
- Visualization of transmitter release with zinc fluorescence detection at the mouse hippocampal mossy fibre synapseJing Qian
Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
J Physiol 566:747-58. 2005..Here we developed a technique to directly assess exocytosis by measuring vesicular zinc release with the zinc-sensitive dye FluoZin-3 at the hippocampal mossy fibre (MF) synapse...
- New insights into the role of zinc in the respiratory epitheliumA Q Truong-Tran
Department of Medicine, University of Adelaide, The Queen Elizabeth Hospital, Woodville, South Australia, Australia
Immunol Cell Biol 79:170-7. 2001Over the past 30 years, many researchers have demonstrated the critical role of zinc (Zn), a group IIb metal, in diverse physiological processes, such as growth and development, maintenance and priming of the immune system, and tissue ..
- The ZRT2 gene encodes the low affinity zinc transporter in Saccharomyces cerevisiaeH Zhao
Department of Biochemistry and Molecular Biology, School of Medicine, University of Minnesota, Duluth, Minnesota 55812, USA
J Biol Chem 271:23203-10. 1996b>Zinc accumulation in Saccharomyces cerevisiae occurs through either of two uptake systems. A high affinity system is active in zinc-limited cells, and the ZRT1 gene encodes the transporter protein of this system...
- Metal chelation and inhibition of bacterial growth in tissue abscessesBrian D Corbin
Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Science 319:962-5. 2008..These results demonstrate that calprotectin is a critical factor in the innate immune response to infection and define metal chelation as a strategy for inhibiting microbial growth inside abscessed tissue...
- Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapseYang Z Huang
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
Neuron 57:546-58. 2008..deletion of its prototypic neurotrophin ligands led us to hypothesize that a non-neurotrophin, the divalent cation zinc, can transactivate TrkB...
- An architectural framework that may lie at the core of the postsynaptic densityMarisa K Baron
Department of Chemistry and Biochemistry, Molecular Biology Institute, University of California, Los Angeles, 611 Charles E Young Drive East, Los Angeles, CA 90095 1570, USA
Science 311:531-5. 2006..Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex...
- MTP1-dependent Zn sequestration into shoot vacuoles suggests dual roles in Zn tolerance and accumulation in Zn-hyperaccumulating plantsJeffery L Gustin
Center for Plant Environmental Stress Physiology, Purdue University, West Lafayette, IN, USA
Plant J 57:1116-27. 2009..goesingense play a role in both Zn tolerance and enhanced Zn uptake and accumulation, via the activation of a systemic Zn deficiency response...
- Immune-enhancing role of vitamin C and zinc and effect on clinical conditionsEva S Wintergerst
Bayer Consumer Care Ltd, Basel, Switzerland
Ann Nutr Metab 50:85-94. 2006..Likewise, zinc undernutrition or deficiency was shown to impair cellular mediators of innate immunity such as phagocytosis, ..
- Zinc-buffering capacity of a eukaryotic cell at physiological pZnArtur Krezel
Division of Human Nutrition, Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555, USA
J Biol Inorg Chem 11:1049-62. 2006In spite of the paramount importance of zinc in biology, dynamic aspects of cellular zinc metabolism remain poorly defined at the molecular level...
- Zinc pyrithione induces cellular stress signaling and apoptosis in Hep-2 cervical tumor cells: the role of mitochondria and lysosomesEmil Rudolf
Department of Medical Biology and Genetics, Faculty of Medicine in Hradec Kralove, Charles University in Prague, 500 01 Hradec Kralove I, Czech Republic
Biometals 23:339-54. 2010Increased intracellular free zinc concentrations are associated with activation of several stress signaling pathways, specific organelle injury and final cell death...
- Arabidopsis V-ATPase activity at the tonoplast is required for efficient nutrient storage but not for sodium accumulationMelanie Krebs
Heidelberg Institute for Plant Sciences, University of Heidelberg, 69120 Heidelberg, Germany
Proc Natl Acad Sci U S A 107:3251-6. 2010..b>Zinc is an essential micronutrient that is toxic at excess concentrations and is detoxified via a vacuolar Zn(2+)/H(+)-..
- Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenalsMichael McMahon
Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland
Proc Natl Acad Sci U S A 107:18838-43. 2010....
- Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunitsC C Curtain
Biomolecular Research Institute, 343 Royal Parade, Parkville, Victoria 3052, Australia
J Biol Chem 276:20466-73. 2001..These reactions may play a deleterious role in the disease state, because high concentrations of iron, copper, and zinc have been located in amyloid in diseased brains...
- Design, synthesis and biological application of chemical probes for bio-imagingKazuya Kikuchi
Graduate School of Engineering, Osaka University, 2 1 Yamada oka, Suita City, Osaka 565 0871, Japan
Chem Soc Rev 39:2048-53. 2010..The MRI signal of the intrinsic (19)F is hardly detectable. A novel design strategy for (19)F MRI probes in detecting protease activity is described...
- Maternal gestational zinc supplementation does not influence multiple aspects of child development at 54 mo of age in PeruLaura E Caulfield
Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Am J Clin Nutr 92:130-6. 2010b>Zinc is necessary for central nervous system development, and maternal zinc status has been associated with developmental differences in offspring.
- Zinc transporter ZnT-3 regulates presynaptic Erk1/2 signaling and hippocampus-dependent memoryCarlos Sindreu
Departments of Pharmacology and Biochemistry and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 108:3366-70. 2011The physiological role of vesicular zinc at central glutamatergic synapses remains poorly understood...
- AdcAII, a new pneumococcal Zn-binding protein homologous with ABC transporters: biochemical and structural analysisElodie Loisel
Institut de Biologie Structurale Jean Pierre Ebel UMR 5075 CNRS CEA UJF PSB, Laboratoire d Ingénierie des Macromolécules, 41 rue Jules Horowitz, 38027 Grenoble, France
J Mol Biol 381:594-606. 2008..Taken together, these functional and structural data provide new perspectives related to the physiological role of AdcAII in pneumococcus Zn homeostasis...
- Activation of the Trk signaling pathway by extracellular zinc. Role of metalloproteinasesJung Jin Hwang
National Creative Research Initiative Center for the Study of CNS Zinc, Department of Neurology, University of Ulsan College of Medicine, Seoul 138-736, Korea
J Biol Chem 280:11995-2001. 2005In certain brain regions, extracellular zinc concentrations can rise precipitously as intense neuronal activity releases large amounts of zinc from the nerve terminals...
- Regulation of metallothionein gene expression by oxidative stress and metal ionsG K Andrews
Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City 66160 7421, USA
Biochem Pharmacol 59:95-104. 2000..essential function of MT has not been demonstrated, MT of higher eukaryotes evolved as a mechanism to regulate zinc levels and distribution within cells and organisms...
- A roadmap for zinc trafficking in the developing barley grain based on laser capture microdissection and gene expression profilingBirgitte Tauris
University of Aarhus, Facultry of Agricultural Sciences, Department of Genetics and Biotechnology, Forsøgsvej 1, 4200 Slagelse, Denmark
J Exp Bot 60:1333-47. 2009..In order to identify transporters and chelating agents that may be involved in transport and deposition of zinc in the barley grain, expression profiles have been generated of four different tissue types: the transfer cells, ..
- Impairment of recognition memory and hippocampal long-term potentiation after acute exposure to clioquinolA Takeda
Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE 21, 52 1 Yada, Surugaku, Shizuoka 422 8526, Japan
Neuroscience 171:443-50. 2010..and has the potential as a scientific and clinical tool used for selective modulation of histochemically reactive zinc pools...
- Zinc deficiency induces enhanced depression-like behaviour and altered limbic activation reversed by antidepressant treatment in miceN Whittle
Department of Pharmacology and Toxicology, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, Austria
Amino Acids 36:147-58. 2009A relationship between zinc (Zn)-deficiency and mood disorders has been suspected...
- A V H H that neutralizes the zinc metalloproteinase activity of botulinum neurotoxin type AJeeraphong Thanongsaksrikul
Department of Immunology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
J Biol Chem 285:9657-66. 2010..A recombinant light chain of type A botulinum toxin, BoTxA/LC, with zinc endoprotease activity was used in phage bio-panning to select phage clones displaying BoTxA/LC-bound VH/V(H)H...
- Constitutively elevated salicylic acid signals glutathione-mediated nickel tolerance in Thlaspi nickel hyperaccumulatorsJohn L Freeman
Center for Plant Environmental Stress Physiology, Purdue University, West Lafayette, Indiana 47907, USA
Plant Physiol 137:1082-91. 2005Progress is being made in understanding the biochemical and molecular basis of nickel (Ni)/zinc (Zn) hyperaccumulation in Thlaspi; however, the molecular signaling pathways that control these mechanisms are not understood...
- Zinc metabolism in airway epithelium and airway inflammation: basic mechanisms and clinical targets. A reviewPeter D Zalewski
Department of Medicine, University of Adelaide, The Queen Elizabeth Hospital, Woodville, South Australia 5011, Australia
Pharmacol Ther 105:127-49. 2005In addition to basic housekeeping roles in metalloenzymes and transcription factors, dietary zinc (Zn) is an important immunoregulatory agent, growth cofactor, and cytoprotectant with anti-oxidant, anti-apoptotic, and anti-inflammatory ..
- Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transportersKathryn M Taylor
Tenovus Cancer Research Centre, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3XF, UK
Biochem J 375:51-9. 2003..contains a potential metalloprotease motif (HEX P H E XGD), which fits the consensus sequence for the catalytic zinc-binding site motif of the zincin metalloproteases...
- Zinc at glutamatergic synapsesP Paoletti
Laboratoire de Neurobiologie, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
Neuroscience 158:126-36. 2009It has long been known that the mammalian forebrain contains a subset of glutamatergic neurons that sequester zinc in their synaptic vesicles. This zinc may be released into the synaptic cleft upon neuronal activity...
- Zinc modulates bidirectional hippocampal plasticity by effects on NMDA receptorsYukitoshi Izumi
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63130, USA
J Neurosci 26:7181-8. 2006b>Zinc has complex effects on NMDA receptors (NMDARs) and may be an endogenous modulator of synaptic plasticity...
- Zinc and copper: pharmacological probes and endogenous modulators of neuronal excitabilityAlistair Mathie
Biophysics Section, Blackett Laboratory, Division of Cell and Molecular Biology, Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom
Pharmacol Ther 111:567-83. 2006As well as being key structural components of many proteins, increasing evidence suggests that zinc and copper ions function as signaling molecules in the nervous system and are released from the synaptic terminals of certain neurons...
- Two genes encoding Arabidopsis halleri MTP1 metal transport proteins co-segregate with zinc tolerance and account for high MTP1 transcript levelsDörthe B Dräger
Max Planck Institute of Molecular Plant Physiology, D 14424 Potsdam, Germany
Plant J 39:425-39. 2004The zinc hyperaccumulator plant Arabidopsis halleri is able to naturally accumulate 100-fold higher leaf zinc concentrations when compared with non-accumulator species such as the closely related A. lyrata and A...
- A novel major facilitator superfamily protein at the tonoplast influences zinc tolerance and accumulation in ArabidopsisMichael J Haydon
Department of Genetics, University of Melbourne, Parkville, Victoria 3010, Australia
Plant Physiol 143:1705-19. 2007b>Zinc (Zn) is an essential micronutrient required by all cells but is toxic in excess. We have identified three allelic Zn-sensitive mutants of Arabidopsis (Arabidopsis thaliana)...
- Induction of mossy fiber --> Ca3 long-term potentiation requires translocation of synaptically released Zn2+Y Li
Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
J Neurosci 21:8015-25. 2001..These results indicate that synaptically released Zn(2+), acting as a second messenger, is necessary for the induction of LTP at mossy fiber-->CA3 synapses of hippocampus...
- Small-molecule fluorescent sensors for investigating zinc metalloneurochemistryElizabeth M Nolan
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Acc Chem Res 42:193-203. 2009The metalloneurochemistry of Zn(II) is of substantial current interest. Zinc is the second most abundant d-block metal ion in the human brain, and its distribution varies with relatively high concentrations found in the hippocampus...
- Therapeutic value of zinc supplementation in acute and persistent diarrhea: a systematic reviewArchana Patel
Lata Medical Research Foundation, Nagpur, India
PLoS ONE 5:e10386. 2010For over a decade, the importance of zinc in the treatment of acute and persistent diarrhea has been recognized...
- D-serine, a selective glycine/N-methyl-D-aspartate receptor agonist, antagonizes the antidepressant-like effects of magnesium and zinc in miceEwa Poleszak
Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Staszica 4, PL 20 081 Lublin, Poland
Pharmacol Rep 60:996-1000. 2008b>Zinc and magnesium are potent inhibitors of the N-methyl-D-aspartate (NMDA) receptor complex...
- Albumin as a zinc carrier: properties of its high-affinity zinc-binding siteJin Lu
Department of Chemistry, University of Warwick, Coventry, UK
Biochem Soc Trans 36:1317-21. 2008Although details of the molecular mechanisms for the uptake of the essential nutrient zinc into the bloodstream and its subsequent delivery to zinc-requiring organs and cells are poorly understood, it is clear that in vertebrates the ..
- Differential effects of zinc influx via AMPA/kainate receptor activation on subsequent induction of hippocampal CA1 LTP componentsAtsushi Takeda
Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE 21, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
Brain Res 1354:188-95. 2010b>Zinc potentiates the induction of NMDA receptor-dependent hippocampal CA1 long-term potentiation (LTP) at low micromolar concentrations, while excessive zinc attenuates it. Homeostasis of synaptic zinc is critical for LTP induction...
- Myelopolyneuropathy and pancytopenia due to copper deficiency and high zinc levels of unknown origin II. The denture cream is a primary source of excessive zincPeter Hedera
Department of Neurology, Vanderbilt University, Nashville, TN 37232 8552, USA
Neurotoxicology 30:996-9. 2009..nervous system associated with hypocupremia and hyperzincinemia has been widely recognized but the origin of high zinc remained unknown...
- Silver ions induce oxidative stress and intracellular zinc release in human skin fibroblastsMiriam M Cortese-Krott
Department of Internal Medicine B, Cardiovascular Research Laboratory, Medical Faculty of the Heinrich Heine University Düsseldorf, D 40225 Dusseldorf, Germany
Free Radic Biol Med 47:1570-7. 2009..Furthermore Ag(+) induces a transient intracellular zinc release and increases the mRNA and protein expression of the zinc-binding protein metallothionein by activating the ..
- Physiological functions of mineral micronutrients (Cu, Zn, Mn, Fe, Ni, Mo, B, Cl)Robert Hansch
Institut fur Pflanzenbiologie, Technische Universitat Braunschweig, Braunschweig, Germany
Curr Opin Plant Biol 12:259-66. 2009..higher plants: boron (B), chloride (Cl), copper (Cu), iron (Fe), manganese (Mn), molybdenum (Mo), nickel (Ni), and zinc (Zn)...
- Increases in extracellular zinc in the amygdala in acquisition and recall of fear experience and their roles in response to fearA Takeda
Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
Neuroscience 168:715-22. 2010The amygdala is enriched with histochemically reactive zinc, which is dynamically coupled with neuronal activity and co-released with glutamate...
- Movement of zinc and its functional significance in the brainA Takeda
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
Brain Res Brain Res Rev 34:137-48. 2000b>Zinc, an essential nutrient, is supplied to the brain via both the blood-brain and blood-cerebrospinal fluid barriers. Zinc is most concentrated in the limbic system, i.e...
- Dose-response trial of prophylactic zinc supplements, with or without copper, in young Ecuadorian children at risk of zinc deficiencySara E Wuehler
Department of Nutrition, Program in International and Community Nutrition, University of California, Davis, Davis, CA 95616, USA
Am J Clin Nutr 87:723-33. 2008Multiple studies have shown the benefits of zinc supplementation among young children in high-risk populations. However, the optimal dose and safe upper level of zinc have not been determined.
- Identification of the Zn2+ binding site and mode of operation of a mammalian Zn2+ transporterEhud Ohana
Department of Physiology, Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel
J Biol Chem 284:17677-86. 2009Vesicular zinc transporters (ZnTs) play a critical role in regulating Zn2+ homeostasis in various cellular compartments and are linked to major diseases ranging from Alzheimer disease to diabetes...
- Influence of brown coal on limit of phytotoxicity of soils contaminated with heavy metalsA Pusz
Warsaw University of Technology, Faculty of Environmental Engineering, Institute of Environmental Engineering Systems, ul Nowowiejska 20, 00 653 Warsaw, Poland
J Hazard Mater 149:590-7. 2007..Results of the paper show that tested fertilizer could be applied on soils strongly contaminated with heavy metals giving long-lasting improvement of reclaimed soils...
- Assessment of metal availability to vegetation (Betula pendula) in Pb-Zn ore concentrate residues with different featuresE Margui
Department of Chemistry, University of Girona, Campus Monitilivi s n, E 17071 Girona, Spain
Environ Pollut 145:179-84. 2007..applied in the different mining wastes in order to study Pb and Zn mobility and likely bioavailability to Betula pendula growing on the same mining spoils, which presents lead and zinc contents in leaves over ten times background values.
- Trend in metals variation in Tasik Chini, Pahang, Peninsular MalaysiaM Shuhaimi-Othman
School of Environmental and Natural Resource Sciences, Faculty of Science and Technology, National University of Malaysia UKM, Bangi, 43600 Selangor, Malaysia
Environ Monit Assess 143:345-54. 2008..2004 until August 2005 and analyzed for 11 metals including iron (Fe), aluminum (Al), manganese (Mn), barium (Ba), zinc (Zn), lead (Pb), copper (Cu), cadmium (Cd), nickel (Ni), chromium (Cr) and cobalt (Co)...
- Tissue heavy metal concentrations of stranded California sea lions (Zalophus californianus) in Southern CaliforniaErin R Harper
SeaWorld San Diego, San Diego, CA 92109, USA
Environ Pollut 147:677-82. 2007..age-dependant increases were observed in liver and kidney concentrations of cadmium and mercury, and renal zinc concentrations. Hepatic iron concentrations were significantly higher in females than males...
- Contents of bioelements and toxic metals in the Polish population determined by hair analysis. Part III. Adults aged 20 to 40 yearsAldona Dunicz-Sokolowska
Polish Academy of Sciences, System Research Institute, ul Newelska 6, 01 447 Warsaw, Poland
Magnes Res 20:43-52. 2007....
- Metal contamination of vineyard soils in wet subtropics (southern Brazil)Nicolai Mirlean
Fundacao Universidade do Rio Grande, Department of Geosciences, Av Italia km 08, Campus Carreiros, CEP 96201 900 Rio Grande RS, Brazil
Environ Pollut 149:10-7. 2007..When evaluating the risks of copper's toxic effects in subtropics, the soils from rhyolitic volcanic rocks are more worrisome, as the Cu extracted with ammonium acetate 1M surpasses the toxic threshold as much as 4-6 times...
- Metals leachability from medical waste incinerator fly ash: A case study on particle size comparisonSukandar Sukandar
Graduate School of Natural Science and Technology, Okayama University, 3 1 1 Tsushima, Naka, Okayama City, Okayama 700 8530, Japan
Environ Pollut 144:726-35. 2006..However, no correlation was found in Kendal-tau correlation analysis between particle size of the ash and metals leachability of the TCLP...
- Characterisation of heavy metal tolerance and biosorption capacity of bacterium strain CPB4 (Bacillus spp.)S U Kim
Department of Biological Environment, Sunchon National University, Sunchon, 540 742, Korea
Water Sci Technol 55:105-11. 2007..The amount of heavy metal uptake was remarkably decreased by reducing the crude protein contents when cells were treated by alkali solutions. Therefore, this study showed one of the possible examples for useful bioremediation...
- Effects of amendments of N, P, Fe on phytoextraction of Cd, Pb, Cu, and Zn in soil of Zhangshi by mustard, cabbage, and sugar beetLina Sun
Shenyang Key Laboratory of Environmental Engineering, Shenyang University, Shenyang 110044, China
Environ Toxicol 22:565-71. 2007..Results of this study could provide some available information for in-site bioremediation of soil from Zhangshi irrigation area...
- Algal-bacterial interactions in metal contaminated floodplain sedimentsM E Y Boivin
National Institute for Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
Environ Pollut 145:884-94. 2007..Metals were, however, not proven to affect either the algal or the bacterial communities of the Dutch river floodplains...
- Trace metal enrichments in core sediments in Muthupet mangroves, SE coast of India: application of acid leachable techniqueD Janaki Raman
Department of Geology, School of Earth and Atmospheric Sciences, University of Madras, Guindy Campus, Chennai 600 025, India
Environ Pollut 145:245-57. 2007..Comparison of acid leachable trace metals indicates increase in concentrations in the study area and the sediments act as a sink for trace metals contributed from multiple sources...
- Trace mineral profile in blood and hair from cattle environmentally exposed to lead and cadmium around different industrial unitsR C Patra
Environmental Medicine Laboratory, Division of Medicine, Indian Veterinary Research Institute, Izatnagar 243 122, UP, India
J Vet Med A Physiol Pathol Clin Med 53:511-7. 2006..to lead and cadmium and to examine if these toxic heavy metals in blood and hair could affect blood copper, cobalt, zinc and iron concentrations and their accumulation in hair...
- Influence of hydrological regime on pore water metal concentrations in a contaminated sediment-derived soilG Du Laing
Laboratory of Analytical Chemistry and Applied Ecochemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, Gent, Belgium
Environ Pollut 147:615-25. 2007..The shorter the flooded periods, the better the metal concentrations could be linked to the mobility of Ca in the pore water, which is attributed to a fluctuating CO(2) pressure...
- Ion-exchange of Pb2+, Cu2+, Zn2+, Cd2+, and Ni2+ ions from aqueous solution by Lewatit CNP 80Erol Pehlivan
Department of Chemical Engineering, Selcuk University, Campus, 42071 Konya, Turkey
J Hazard Mater 140:299-307. 2007..We conclude that Lewatit CNP 80 can be used for the efficient removal of Pb(2+), Cu(2+), Zn(2+), Cd(2+), and Ni(2+) from aqueous solutions...
- FUNCTIONAL ANALYSIS OF A LEAD/CADMIUM/ZINC ATPASEBharati Mitra; Fiscal Year: 2010..These pumps maintain homeostasis of essential trace metals like copper, zinc, cobalt and nickel, and mediate resistance to toxic metals such as lead, cadmium and silver...
- REGULATION OF CELLULAR ZINC HOMEOSTASISDavid Eide; Fiscal Year: 2009b>Zinc is an essential nutrient because of the important roles this metal plays as a catalytic and structural cofactor...
- Arsenic-enhanced skin carcinogenesis by UV radiationKe Liu; Fiscal Year: 2009..Proposed protein targets of arsenite include Poly (ADP-ribose) polymerase (PARP)- 1, a protein with two C3H1 zinc finger motifs in the DNA binding domain and one C4 zinc binding motif responsible for DNA-dependent catalytic ..
- Zinc inhibition of endotoxemia in alcoholic liver injuryZhanxiang Zhou; Fiscal Year: 2009b>Zinc inhibition of endotoxemia in alcoholic liver injury Abstract Alcoholic liver disease (ALD) is an important health problem, but an FDA-approved effective therapy is not available...
- Malaria in Pregnancy: Nutrition and Immunologic EffectsWafaie W Fawzi; Fiscal Year: 2010..Vitamin A and zinc deficiencies are specific factors which can modulate the clinical course of malaria and exacerbate associated ..
- FUNCTIONAL ANALYSIS OF A LEAD/CADMIUM/ZINC ATPASEBharati Mitra; Fiscal Year: 2007..These pumps maintain homeostasis of essential trace metals like copper, zinc, cobalt and nickel, and mediate resistance to toxic metals such as lead, cadmium and silver...
- Zinc inhibition of endotoxemia in alcoholic liver injuryZhanxiang Zhou; Fiscal Year: 2010b>Zinc inhibition of endotoxemia in alcoholic liver injury Abstract Alcoholic liver disease (ALD) is an important health problem, but an FDA-approved effective therapy is not available...
- ZINC COORDINATION AND REGULATION OF ZINC METALLOPROTEINSDAVID GIEDROC; Fiscal Year: 2003..continued support for ongoing studies of the structure, bioinorganic chemistry and allosteric regulation by zinc of selected zinc metalloregulatory transcription factors derived from mammalian and prokaryotic organisms which ..
- Investigation of Zinc Neurochemistry by Optical Sensing and MRIStephen J Lippard; Fiscal Year: 2010..The long-term goal of this research is to devise molecular sensors for binding, visualizing, and quantifying mobile zinc in neurobiological systems...
- Genomic analysis of pediatric SIRS and septic shockHector Wong; Fiscal Year: 2009..The competitive revision seeks to develop a point-of-care platform for measuring serum zinc concentrations in children with septic shock, the "zinc chip...
- Effect of Zinc in Attaching and Effacing E. coli InfectionJOHN K contact CRANE; Fiscal Year: 2010b>Zinc has been shown to reduce the duration and severity of diarrheal diseases in studies of poor children on several continents...
- Structural Investigation of Allosteric Regulation in Bacterial Carbonic AnhydraseJEFF CRONK; Fiscal Year: 2007..and physiological importance, the interconversion of carbon dioxide and bicarbonate ion CO2 + H2O - All CAs are zinc-dependent enzymes and a well-established mechanistic paradigm requires the coordination of substrate to the ..
- Human Zinc Transporter Zip 13 and Cellular Zinc HomeostasisJoel Walker; Fiscal Year: 2007b>Zinc is an essential nutrient needed for many cellular processes, however, excess zinc leads to cell death...
- Towards tuberculosis control: pyrazinamide susceptibility and resistant mechanismPatricia Sheen; Fiscal Year: 2007..site, will revert its PZase activity, turning to a PZA-sensitive phenotype, under high concentrations of zinc ions, the probable cofactor...
- REGULATION OF CELLULAR ZINC HOMEOSTASISDavid J Eide; Fiscal Year: 2010b>Zinc is an essential nutrient because of the important roles this metal plays as a catalytic and structural cofactor...
- SYNTHETIC ANALOGUES OF ZINC ENZYMESGerard Parkin; Fiscal Year: 2003DESCRIPTION: (Adapted from applicant's abstract) Zinc is widely recognized as being essential to all forms of life, and in particular that of humans...
- THE ROLE OF ZINC FINGER GENES IN HEMATOPOIESISSinisa Dovat; Fiscal Year: 2003..Ikaros encodes a zinc finger protein whose expression is restricted to hematopoietic cells...
- DIETARY ZINC-ITS EFFECTS ON THE IMMUNE RESPONSEPamela Fraker; Fiscal Year: 2007The zinc deficient mouse (ZD) is a valuable model for elucidating the molecular and biochemical changes made by the immune system to provide a core of host defense in the face of suboptimal nutriture...