zinc

Summary

Summary: A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.

Top Publications

  1. pmc Zinc in human health: effect of zinc on immune cells
    Ananda S Prasad
    Wayne State University School of Medicine, Detroit, Michigan 48201, United States of America
    Mol Med 14:353-7. 2008
  2. pmc Zinc homeostasis and signaling in health and diseases: Zinc signaling
    Toshiyuki Fukada
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, 230 0045, Japan
    J Biol Inorg Chem 16:1123-34. 2011
  3. pmc Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease
    James A Duce
    Mental Health Research Institute, The University of Melbourne, Parkville, Victoria 3052, Australia
    Cell 142:857-67. 2010
  4. ncbi Metallo-beta-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily
    Carine Bebrone
    Center for Protein Engineering Biological Macromolecules, University of Liege, Allée du 6 Août B6, Sart Tilman 4000 Liège, Belgium
    Biochem Pharmacol 74:1686-701. 2007
  5. ncbi Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis
    C E Outten
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Science 292:2488-92. 2001
  6. ncbi A NAC Gene regulating senescence improves grain protein, zinc, and iron content in wheat
    Cristobal Uauy
    Department of Plant Sciences, University of California, One Shields Avenue, Davis, CA 95616, USA
    Science 314:1298-301. 2006
  7. ncbi Zinc finger proteins: new insights into structural and functional diversity
    J H Laity
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Struct Biol 11:39-46. 2001
  8. doi Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta
    Paul A Adlard
    Oxidation Biology Laboratory, The Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia
    Neuron 59:43-55. 2008
  9. pmc Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation
    Michal Sheffer
    Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100, Israel
    Oncotarget 2:1191-202. 2011
  10. pmc miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells
    Brittany L Mihelich
    Department of Pathology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 286:44503-11. 2011

Detail Information

Publications342 found, 100 shown here

  1. pmc Zinc in human health: effect of zinc on immune cells
    Ananda S Prasad
    Wayne State University School of Medicine, Detroit, Michigan 48201, United States of America
    Mol Med 14:353-7. 2008
    Although the essentiality of zinc for plants and animals has been known for many decades, the essentiality of zinc for humans was recognized only 40 years ago in the Middle East...
  2. pmc Zinc homeostasis and signaling in health and diseases: Zinc signaling
    Toshiyuki Fukada
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, 230 0045, Japan
    J Biol Inorg Chem 16:1123-34. 2011
    The essential trace element zinc (Zn) is widely required in cellular functions, and abnormal Zn homeostasis causes a variety of health problems that include growth retardation, immunodeficiency, hypogonadism, and neuronal and sensory ..
  3. pmc Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease
    James A Duce
    Mental Health Research Institute, The University of Melbourne, Parkville, Victoria 3052, Australia
    Cell 142:857-67. 2010
    ..Abnormal exchange of cortical zinc may link amyloid pathology with neuronal iron accumulation in AD.
  4. ncbi Metallo-beta-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily
    Carine Bebrone
    Center for Protein Engineering Biological Macromolecules, University of Liege, Allée du 6 Août B6, Sart Tilman 4000 Liège, Belgium
    Biochem Pharmacol 74:1686-701. 2007
    ..In the last few years, many new zinc beta-lactamases have been described and several pathogens are now known to synthesize members of this class...
  5. ncbi Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis
    C E Outten
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Science 292:2488-92. 2001
    Intracellular zinc is thought to be available in a cytosolic pool of free or loosely bound Zn(II) ions in the micromolar to picomolar range...
  6. ncbi A NAC Gene regulating senescence improves grain protein, zinc, and iron content in wheat
    Cristobal Uauy
    Department of Plant Sciences, University of California, One Shields Avenue, Davis, CA 95616, USA
    Science 314:1298-301. 2006
    ..here the positional cloning of Gpc-B1, a wheat quantitative trait locus associated with increased grain protein, zinc, and iron content...
  7. ncbi Zinc finger proteins: new insights into structural and functional diversity
    J H Laity
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Struct Biol 11:39-46. 2001
    b>Zinc finger proteins are among the most abundant proteins in eukaryotic genomes...
  8. doi Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta
    Paul A Adlard
    Oxidation Biology Laboratory, The Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia
    Neuron 59:43-55. 2008
    ..The speed of recovery of the animals underscores the acutely reversible nature of the cognitive deficits associated with transgenic models of AD...
  9. pmc Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation
    Michal Sheffer
    Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100, Israel
    Oncotarget 2:1191-202. 2011
    ..b>Zinc supplementation has been shown to counteract the hypoxic phenotype in cancer cells, in vitro and in vivo, hence, ..
  10. pmc miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells
    Brittany L Mihelich
    Department of Pathology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 286:44503-11. 2011
    Decreased zinc levels are a hallmark of prostate cancer tumors as zinc uniquely concentrates in healthy prostate tissue...
  11. pmc The neurophysiology and pathology of brain zinc
    Stefano L Sensi
    Department of Neuroscience and Imaging, Molecular Neurology Unit, CeSI Center for Excellence on Aging, University G D Annunzio, Chieti 66013, Italy
    J Neurosci 31:16076-85. 2011
    Our understanding of the roles played by zinc in the physiological and pathological functioning of the brain is rapidly expanding...
  12. ncbi Metallothionein: the multipurpose protein
    P Coyle
    Division of Clinical Biochemistry, Institute of Medical and Veterinary Science, Adelaide, SA
    Cell Mol Life Sci 59:627-47. 2002
    ..Use of mice with altered gene expression has enhance our understanding of the multifaceted role of MT, emphasised in this review...
  13. ncbi Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials
    Kenneth H Brown
    Program in International Nutrition and the Department of Nutrition, University of California, Davis 95616, USA
    Am J Clin Nutr 75:1062-71. 2002
    Multiple studies have been carried out to assess the effect of zinc supplementation on children's growth. The results of these studies are inconsistent, and the factors responsible for these varied outcomes are unknown.
  14. doi Zinc in the physiology and pathology of the CNS
    Stefano L Sensi
    Department of Basic and Applied Medical Science, Molecular Neurology Unit, CeSI Center for Excellence on Aging, University G dAnnunzio, Chieti, 66013, Italy
    Nat Rev Neurosci 10:780-91. 2009
    The past few years have witnessed dramatic progress on all frontiers of zinc neurobiology...
  15. doi Molecular mechanisms of metal hyperaccumulation in plants
    Nathalie Verbruggen
    Universite Libre de Bruxelles, B 1050 Brussels, Belgium
    New Phytol 181:759-76. 2009
    ..This review presents key aspects of our current understanding of plant metal – in particular cadmium (Cd),nickel (Ni) and zinc (Zn) – hyperaccumulation.
  16. ncbi Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells
    Weidong Wu
    Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 278:28258-63. 2003
    ..Pretreatment of the cells with a proteasome inhibitor significantly blocked zinc-induced reduction of PTEN protein as well as the increase in Akt phosphorylation, implicating the involvement of ..
  17. pmc Mycobacterial p(1)-type ATPases mediate resistance to zinc poisoning in human macrophages
    Hélène Botella
    Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
    Cell Host Microbe 10:248-59. 2011
    ..genes encoding heavy metal efflux P-type ATPases CtpC, CtpG, and CtpV, and host cell metallothioneins and zinc exporter ZnT1, were induced during infection...
  18. pmc Iron, zinc and copper in the Alzheimer's disease brain: a quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion
    Matthew Schrag
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, CA, USA
    Prog Neurobiol 94:296-306. 2011
    ..Although questioned by some, brain copper, zinc, and particularly iron overload are widely accepted features of AD which have led to the hypothesis that oxidative ..
  19. pmc Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureus
    Thomas E Kehl-Fie
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cell Host Microbe 10:158-64. 2011
    By sequestering manganese and zinc, the neutrophil protein calprotectin plays a crucial role in host defense against bacterial and fungal pathogens. However, the essential processes disrupted by calprotectin remain unknown...
  20. ncbi Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs
    Rosa Puca
    National Cancer Institute Regina Elena, Rome, Italy
    Cell Cycle 10:1679-89. 2011
    ..inhibition of DNA binding and transcriptional activities that correlate with increased chemoresistance, and that zinc rescues wild-type p53 activity...
  21. ncbi The adaptive response to dietary zinc in mice involves the differential cellular localization and zinc regulation of the zinc transporters ZIP4 and ZIP5
    Jodi Dufner-Beattie
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160 7421, USA
    J Biol Chem 279:49082-90. 2004
    The ZIP5 gene encodes a protein closely related to ZIP4, a zinc transporter mutated in the human genetic disorder acrodermatitis enteropathica...
  22. ncbi Zinc and cognitive development
    S Bhatnagar
    All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Br J Nutr 85:S139-45. 2001
    ..b>Zinc deficiency may affect cognitive development by alterations in attention, activity, neuropsychological behavior and ..
  23. pmc A fungal family of transcriptional regulators: the zinc cluster proteins
    Sarah MacPherson
    Department of Microbiology and Immunology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada H3A 1A
    Microbiol Mol Biol Rev 70:583-604. 2006
    The trace element zinc is required for proper functioning of a large number of proteins, including various enzymes. However, most zinc-containing proteins are transcription factors capable of binding DNA and are named zinc finger proteins...
  24. ncbi The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice
    Jodi Dufner-Beattie
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160 7421, USA
    J Biol Chem 278:33474-81. 2003
    The human ZIP4 gene (SLC39A4) is a candidate for the genetic disorder of zinc metabolism acrodermatitis enteropathica. To understand its role in zinc homeostasis, we examined the function and expression of mouse ZIP4...
  25. ncbi Mechanisms of nutrient modulation of the immune response
    Susanna Cunningham-Rundles
    Host Defenses Program, Department of Pediatrics, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY, USA
    J Allergy Clin Immunol 115:1119-28; quiz 1129. 2005
    Lack of adequate macronutrients or selected micronutrients, especially zinc, selenium, iron, and the antioxidant vitamins, can lead to clinically significant immune deficiency and infections in children...
  26. ncbi Mammalian zinc transport, trafficking, and signals
    Robert J Cousins
    Nutritional Genomics Laboratory, Food Science and Human Nutrition Department, Center for Nutritional Sciences, University of Florida, Gainesville, Florida 32611 0370, USA
    J Biol Chem 281:24085-9. 2006
  27. ncbi Counting the zinc-proteins encoded in the human genome
    Claudia Andreini
    Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019 Sesto Fiorentino, Italy
    J Proteome Res 5:196-201. 2006
    ..proposes a strategy to answer the question of how many and which proteins encoded in the human genome may require zinc for their physiological function...
  28. doi Metal chelation and inhibition of bacterial growth in tissue abscesses
    Brian D Corbin
    Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Science 319:962-5. 2008
    ..These results demonstrate that calprotectin is a critical factor in the innate immune response to infection and define metal chelation as a strategy for inhibiting microbial growth inside abscessed tissue...
  29. doi Mammalian zinc transporters: nutritional and physiologic regulation
    Louis A Lichten
    Nutritional Genomics Laboratory, Food Science and Human Nutrition Department and Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611 2710, USA
    Annu Rev Nutr 29:153-76. 2009
    Research advances defining how zinc is transported into and out of cells and organelles have increased exponentially within the past five years...
  30. pmc Low micromolar zinc accelerates the fibrillization of human tau via bridging of Cys-291 and Cys-322
    Zhong Ying Mo
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
    J Biol Chem 284:34648-57. 2009
    ..There is considerable evidence showing that zinc, as an essential element that is highly concentrated in brain, is linked to the development or progression of these ..
  31. ncbi Zinc coordination sphere in biochemical zinc sites
    D S Auld
    Center for Biochemical and Biophysical Sciences and Medicine and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biometals 14:271-313. 2001
    b>Zinc is known to be indispensable to growth and development and transmission of the genetic message. It does this through a remarkable mosaic of zinc binding motifs that orchestrate all aspects of metabolism...
  32. doi Cu/Zn ratios are associated with nutritional status, oxidative stress, inflammation, and immune abnormalities in patients on peritoneal dialysis
    Chih Hung Guo
    Institute of Biomedical Nutrition, Hung Kuang University, Taichung 433, Taiwan, ROC
    Clin Biochem 44:275-80. 2011
    We evaluated the relationship of the plasma copper/zinc (Cu/Zn) ratio with nutritional status, inflammation, oxidative stress, and immune function in peritoneal dialysis patients.
  33. doi Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4
    Marc Hanikenne
    Max Planck Institute of Molecular Plant Physiology, D 14476 Potsdam, Germany
    Nature 453:391-5. 2008
    ..A. halleri naturally accumulates and tolerates leaf concentrations as high as 2.2% zinc and 0.28% cadmium in dry biomass. On the basis of transcriptomics studies, metal hyperaccumulation in A...
  34. doi Molecular and genetic features of zinc transporters in physiology and pathogenesis
    Toshiyuki Fukada
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    Metallomics 3:662-74. 2011
    b>Zinc (Zn) is a vital element...
  35. pmc Intracellular zinc release-activated ERK-dependent GSK-3β-p53 and Noxa-Mcl-1 signaling are both involved in cardiac ischemic-reperfusion injury
    C L Lin
    Institute of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cell Death Differ 18:1651-63. 2011
    ..Thus, acute upstream Zn(2+)(i) chelation at the start of reperfusion and the use of natural products, that is, flavonoids, may be beneficial in the treatment of cardiac I/R injury...
  36. pmc Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response
    Juan P Liuzzi
    Nutritional Genomics Laboratory, Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611, USA
    Proc Natl Acad Sci U S A 102:6843-8. 2005
    ..The latter involves regulation of the iron transporter ferroportin 1 by hepcidin. The mechanism of reduced plasma zinc is not known...
  37. doi Think zinc: New roles for zinc in the control of insulin secretion
    Guy A Rutter
    Department of Cell Biology, Imperial College London, UK
    Islets 2:49-50. 2010
    Genome wide association studies have identified the islet-restricted zinc transporter ZnT8 (SLC30A8) as a likely player in the control of insulin secretion and the risk of developing type 2 diabetes...
  38. doi The missing zinc: p53 misfolding and cancer
    Stewart N Loh
    Department of Biochemistry and Molecular Biology, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Metallomics 2:442-9. 2010
    The p53 tumor suppressor is a transcription factor that contains a single zinc ion near its DNA binding interface. Zn(2+) is required for site-specific DNA binding and proper transcriptional activation...
  39. pmc Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants
    Tamara J Nicolson
    Section of Cell Biology, Division of Medicine, Imperial College London, London, U K
    Diabetes 58:2070-83. 2009
    b>Zinc ions are essential for the formation of hexameric insulin and hormone crystallization...
  40. doi Study on clinical and biochemical toxicity biomarkers in a zinc-lead mine workers
    Ali Akbar Malekirad
    Science and Research Branch, Islamic Azad University IAU, Tehran, Iran
    Toxicol Ind Health 26:331-7. 2010
    The aim of this study was to determine oxidative stress status as well as blood lead (Pb) and zinc (Zn) levels and clinical markers in workers of a Zn-Pb mine...
  41. doi Zinc: role in immunity, oxidative stress and chronic inflammation
    Ananda S Prasad
    Department of Internal Medicine, Division of Hematology Oncology, Wayne State University, School of Medicine, Detroit, Michigan, USA
    Curr Opin Clin Nutr Metab Care 12:646-52. 2009
    b>Zinc is essential for multiple cellular functions including immunity. Many investigators have used zinc supplementation in an attempt to affect the outcome of various diseases...
  42. pmc HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation
    Lavinia Nardinocchi
    Department of Experimental Oncology, Molecular Oncogenesis Laboratory, National Cancer Institute Regina Elena, Rome, Italy
    Aging (Albany NY) 3:33-43. 2011
    ..Inhibition of HIF-1α by siRNA, HIF-1α-dominant negative or by zinc re-established the HIPK2 levels and the p53-mediated chemosensitivity in tumor cells...
  43. pmc The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways
    Toshiyuki Fukada
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Tsurumi, Yokohama, Kanagawa, Japan
    PLoS ONE 3:e3642. 2008
    b>Zinc (Zn) is an essential trace element and it is abundant in connective tissues, however biological roles of Zn and its transporters in those tissues and cells remain unknown.
  44. ncbi International Zinc Nutrition Consultative Group (IZiNCG) technical document #1. Assessment of the risk of zinc deficiency in populations and options for its control
    Kenneth H Brown
    Program in International Nutrition, University of California, Davis, USA
    Food Nutr Bull 25:S99-203. 2004
  45. ncbi The mouse acrodermatitis enteropathica gene Slc39a4 (Zip4) is essential for early development and heterozygosity causes hypersensitivity to zinc deficiency
    Jodi Dufner-Beattie
    Department of Biochemistry and Molecular Biology, University of Virginia School of Medicine, PO Box 800734, Charlottesville, VA 22908, USA
    Hum Mol Genet 16:1391-9. 2007
    The human Zip4 gene (Slc39a4) is mutated in the rare recessive genetic disorder of zinc metabolism acrodermatitis enteropathica, but the physiological functions of Zip4 are not well understood...
  46. doi Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion
    N Wijesekara
    Department of Physiology, University of Toronto, 1 King s College Circle Room 3352, Toronto, ON, Canada M5S 1A8
    Diabetologia 53:1656-68. 2010
    b>Zinc is highly concentrated in pancreatic beta cells, is critical for normal insulin storage and may regulate glucagon secretion from alpha cells...
  47. doi A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses
    Atul Deshpande
    Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697, USA
    J Neurosci 29:4004-15. 2009
    ..The zinc-binding 8-OH-quinoline clioquinol markedly reduced AbetaO synaptic targeting, which was also reduced in brain ..
  48. doi Roles of zinc and zinc signaling in immunity: zinc as an intracellular signaling molecule
    Toshio Hirano
    Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Adv Immunol 97:149-76. 2008
    b>Zinc (Zn) is an essential nutrient required for cell growth, differentiation, and survival, and its deficiency causes growth retardation, immunodeficiency, and other health problems...
  49. pmc Contributions of Zur-controlled ribosomal proteins to growth under zinc starvation conditions
    Scott E Gabriel
    Department of Microbiology, Cornell University, Ithaca, NY 14853 8101, USA
    J Bacteriol 191:6116-22. 2009
    Maintaining intracellular zinc levels is critical, because zinc serves as a cofactor for many required enzymes and is toxic in excess...
  50. ncbi Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence
    Jian Dong
    Department of Biochemistry, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    Biochemistry 42:2768-73. 2003
    ..The results also reveal a direct chemical basis for oxidative damage caused by amyloid-beta protein in AD...
  51. ncbi Preventive zinc supplementation among infants, preschoolers, and older prepubertal children
    Kenneth H Brown
    Department of Nutrition, University of California, Davis, California 95616, USA
    Food Nutr Bull 30:S12-40. 2009
    b>Zinc supplementation trials carried out among children have produced variable results, depending on the specific outcomes considered and the initial characteristics of the children who were enrolled...
  52. ncbi Zinc in plants
    Martin R Broadley
    Plant Sciences Division, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK
    New Phytol 173:677-702. 2007
    b>Zinc (Zn) is an essential component of thousands of proteins in plants, although it is toxic in excess...
  53. ncbi A comparison of the Thlaspi caerulescens and Thlaspi arvense shoot transcriptomes
    John P Hammond
    Warwick HRI, University of Warwick, Wellesbourne, Warwick CV35 9EF, UK
    New Phytol 170:239-60. 2006
    ..of a robust method to profile and compare the transcriptomes of two nonmodel plant species, Thlaspi caerulescens, a zinc (Zn) hyperaccumulator, and Thlaspi arvense, a nonhyperaccumulator, using Affymetrix Arabidopsis thaliana ATH1-..
  54. pmc Synaptically released zinc triggers metabotropic signaling via a zinc-sensing receptor in the hippocampus
    Limor Besser
    Department of Morphology, Ben Gurion University, Beer Sheva 84105, Israel
    J Neurosci 29:2890-901. 2009
    ..Our results describe a unique role for synaptic Zn(2+) acting as the physiological ligand of a metabotropic receptor and provide a novel pathway by which synaptic Zn(2+) can regulate neuronal function...
  55. ncbi The ZnuABC high-affinity zinc uptake system and its regulator Zur in Escherichia coli
    S I Patzer
    Mikrobiologie Membranphysiologie, Universitat Tubingen, Germany
    Mol Microbiol 28:1199-210. 1998
    ..This high-affinity transport was energized by ATP. The genes were named znuACB (for zinc uptake; former name yebLMI) and localized at 42 min on the genetic map of E. coli...
  56. ncbi Use of national food balance data to estimate the adequacy of zinc in national food supplies: methodology and regional estimates
    Sara E Wuehler
    Department of Nutrition and Program in International Nutrition, University of California Davis, Davis, CA 95616, USA
    Public Health Nutr 8:812-9. 2005
    Adequate zinc nutriture is critically important for human health, but the development of programmes to control zinc deficiency is limited by the lack of reliable information on population zinc status...
  57. doi Exacerbation of diabetes-induced testicular apoptosis by zinc deficiency is most likely associated with oxidative stress, p38 MAPK activation, and p53 activation in mice
    Yuguang Zhao
    Cancer Center, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China
    Toxicol Lett 200:100-6. 2011
    Since diabetes induces testicular oxidative damage and cell death, and zinc (Zn) plays an important role in the spermatogenesis, the objective of the present study was to define the effects of Zn deficiency on diabetes-induced testicular ..
  58. pmc New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc
    C Corona
    Molecular Neurology Unit, Center of Excellence on Aging CeSI, Chieti, Italy
    Cell Death Dis 2:e176. 2011
    ..for the disease is the development of an unbalanced homeostasis of two signaling cations: calcium (Ca(2+)) and zinc (Zn(2+))...
  59. doi Level of trace elements (copper, zinc, magnesium and selenium) and toxic elements (lead and mercury) in the hair and nail of children with autism
    Malarveni Damodaran Lakshmi Priya
    Department of Biochemistry, Bharathi Women s College, Chennai, 600 108 Tamil Nadu, India
    Biol Trace Elem Res 142:148-58. 2011
    ..Therefore, the purpose of the present study was to assess the levels of trace elements like copper (Cu), zinc (Zn), magnesium (Mg), and selenium (Se) and toxic elements like mercury (Hg), and lead (Pb) in the hair and nail ..
  60. doi Zinc restriction during different periods of life: influence in renal and cardiovascular diseases
    Analía Lorena Tomat
    Catedra de Fisiologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, IQUIMEFA CONICET, Junin 956, Piso 7, Ciudad Autonoma de Buenos Aires, Argentina 1113
    Nutrition 27:392-8. 2011
    ..b>Zinc is a widely studied microelement in infant feeding because it is a component of several enzymes involved in ..
  61. pmc Zinc availability regulates exit from meiosis in maturing mammalian oocytes
    Alison M Kim
    Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
    Nat Chem Biol 6:674-81. 2010
    ..Here we describe major changes in the zinc physiology of the mammalian oocyte as it matures and initiates embryonic development...
  62. ncbi Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING
    Allan D Capili
    Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    J Mol Biol 340:1117-29. 2004
    ..Notably, RING2 binds only one zinc atom per monomer rather than two and uses a different hydrophobic network to that of classical RINGs...
  63. pmc Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans
    John T Murphy
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 7:e1002013. 2011
    b>Zinc is an essential trace element involved in a wide range of biological processes and human diseases. Zinc excess is deleterious, and animals require mechanisms to protect against zinc toxicity...
  64. ncbi Impact of the discovery of human zinc deficiency on health
    Ananda S Prasad
    Wayne State University School of Medicine, 1122 Elliman Bldg, 421 East Canfield, Detroit, MI 48201, USA
    J Am Coll Nutr 28:257-65. 2009
    The essentiality of zinc was recognized 46 years ago. Zinc deficiency resulting in growth retardation, hypogonadism, immune dysfunction and cognitive impairment affects nearly 2 billion subjects in the developing world...
  65. pmc Zinc is a novel intracellular second messenger
    Satoru Yamasaki
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan
    J Cell Biol 177:637-45. 2007
    b>Zinc is an essential trace element required for enzymatic activity and for maintaining the conformation of many transcription factors; thus, zinc homeostasis is tightly regulated...
  66. pmc Zinc ions promote Alzheimer Abeta aggregation via population shift of polymorphic states
    Yifat Miller
    Center for Cancer Research Nanobiology Program, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 107:9490-5. 2010
    ..factor in Alzheimer's disease etiology is enrichment of Zn(2+) in aggregates, and there are data suggesting that zinc promotes aggregation, how Zn(2+)-Abeta coordination promotes aggregation is elusive...
  67. pmc Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation
    Andreas M Grabrucker
    Institute of Anatomy and Cell Biology, University of Ulm, Ulm, Germany
    EMBO J 30:569-81. 2011
    ..postsynapses and comparing this to shRNA-mediated knockdown, we could demonstrate that only the overexpression of zinc-sensitive ProSAP1/Shank2 or ProSAP2/Shank3 leads to increased synapse density, although all of them cause a ..
  68. pmc The zinc dyshomeostasis hypothesis of Alzheimer's disease
    Travis J A Craddock
    Department of Physics, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 7:e33552. 2012
    ..The mechanisms linking Aβ and NFT pathologies in AD are unknown. Here, we propose that sequestration of zinc by Aβ-amyloid deposits (Aβ oligomers and plaques) not only drives Aβ aggregation, but also disrupts zinc ..
  69. pmc Effect of supplementation with zinc and other micronutrients on malaria in Tanzanian children: a randomised trial
    Jacobien Veenemans
    Wageningen University, Cell Biology and Immunology Group, Wageningen, The Netherlands
    PLoS Med 8:e1001125. 2011
    It is uncertain to what extent oral supplementation with zinc can reduce episodes of malaria in endemic areas. Protection may depend on other nutrients...
  70. pmc Regulation of T cell receptor signaling by activation-induced zinc influx
    Mingcan Yu
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 208:775-85. 2011
    b>Zinc is a trace element that is essential for innate and adaptive immune responses. In addition to being a structural element of many proteins, zinc also functions as a neurotransmitter and an intracellular messenger...
  71. doi Zinc supplement greatly improves the condition of parkin mutant Drosophila
    Nidhi Saini
    Institute of Molecular Life Sciences, University of Zurich, Switzerland
    Biol Chem 391:513-8. 2010
    ..In a Drosophila disease model lacking Parkin (park(25) null mutant), we tested the effect of zinc supplementation. Zinc is an essential trace metal and a component of many enzymes and transcriptional regulators...
  72. pmc The essential toxin: impact of zinc on human health
    Laura M Plum
    Institute of Immunology, Medical Faculty, RWTH Aachen University, Pauwelstrasse 30, 52074 Aachen, Germany
    Int J Environ Res Public Health 7:1342-65. 2010
    Compared to several other metal ions with similar chemical properties, zinc is relatively harmless. Only exposure to high doses has toxic effects, making acute zinc intoxication a rare event...
  73. pmc The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitation
    H Zhao
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Minnesota, Duluth 55812, USA
    Proc Natl Acad Sci U S A 93:2454-8. 1996
    The yeast Saccharomyces cerevisiae has two separate systems for zinc uptake. One system has high affinity for substrate and is induced in zinc-deficient cells...
  74. pmc Zinc enhances long-term potentiation through P2X receptor modulation in the hippocampal CA1 region
    Ramón A Lorca
    Laboratorio de Neurociencias, Departamento de Biologia, Facultad de Quimica y Biologia, Universidad de Santiago de Chile, Santiago 9170022, Chile
    Eur J Neurosci 33:1175-85. 2011
    ..Although it is not yet clear which purinergic receptor subtype(s) is responsible for these effects on LTP, the data presented here suggest that P2X₄ but not P2X₇ is involved...
  75. pmc Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice
    K Lemaire
    Gene Expression Unit, Department Molecular Cell Biology, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 106:14872-7. 2009
    b>Zinc co-crystallizes with insulin in dense core secretory granules, but its role in insulin biosynthesis, storage and secretion is unknown...
  76. doi Phase perfection in zinc Blende and Wurtzite III-V nanowires using basic growth parameters
    Hannah J Joyce
    Department of Electronic Materials Engineering, Research School of Physics and Engineering, The Australian National University, Canberra, ACT 0200, Australia
    Nano Lett 10:908-15. 2010
    ..Phase purity is achieved without sacrificing important specifications of diameter and dopant levels. Pure zinc blende nanowires, free of twin defects, were achieved using a low growth temperature coupled with a high V/III ..
  77. ncbi Tooth hardness increases with zinc-content in mandibles of young adult leaf-cutter ants
    Robert M S Schofield
    Department of Physics, University of Oregon, Eugene, OR 97403, USA
    Naturwissenschaften 89:579-83. 2002
    ..91). We suggest that young adults rarely cut leaves partly because their mandibles are not yet rich in Zn. Zinc enrichment (along with enrichment by other heavy metals and halogens) may play an unrecognized role in the ..
  78. ncbi Cytotoxic effects of intra and extracellular zinc chelation on human breast cancer cells
    Mohammad Hashemi
    Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
    Eur J Pharmacol 557:9-19. 2007
    b>Zinc is an essential trace element with cofactor functions in a large number of proteins of intermediary metabolism, hormone secretion pathways, immune defence mechanisms, and as a cofactor of transcription factors it is also involved in ..
  79. ncbi Effects of cadmium and zinc on plasma levels of growth hormone, insulin-like growth factor I, and insulin-like growth factor-binding protein 3
    Sebahat Turgut
    Department of Physiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey
    Biol Trace Elem Res 108:197-204. 2005
    Humans are constantly exposed to cadmium (Cd) as a result of the increase in air pollution and cigaret use. Zinc (Zn), which is an essential element for the metabolism of and the constituent of many enzymes, causes growth retardation in ..
  80. doi Effects of zinc on plasma lipoprotein cholesterol concentrations in humans: a meta-analysis of randomised controlled trials
    Meika Foster
    Discipline of Nutrition and Metabolism, School of Molecular and Microbial Biosciences, University of Sydney NSW 2006, Australia
    Atherosclerosis 210:344-52. 2010
    Studies in humans and animals suggest that zinc has the potential to affect lipoprotein metabolism and hence impact cardiovascular disease risk.
  81. doi Zinc deficiency induces depression-like symptoms in adult rats
    Nadine M Tassabehji
    Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, Florida 32306 4340, United States
    Physiol Behav 95:365-9. 2008
    There is mounting evidence suggesting a link between serum zinc levels and clinical depression...
  82. pmc Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction but not the immediate-type reaction
    Keigo Nishida
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
    J Exp Med 206:1351-64. 2009
    b>Zinc (Zn) is an essential nutrient and its deficiency causes immunodeficiency. However, it remains unknown how Zn homeostasis is regulated in mast cells and if Zn transporters are involved in allergic reactions...
  83. doi Transient fluctuations of intracellular zinc ions in cell proliferation
    Yuan Li
    Division of Human Nutrition, Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Exp Cell Res 315:2463-70. 2009
    b>Zinc is essential for cell proliferation, differentiation, and viability. When zinc becomes limited for cultured cells, DNA synthesis ceases and the cell cycle is arrested...
  84. doi Intracellular zinc homeostasis and zinc signaling
    Masaaki Murakami
    Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
    Cancer Sci 99:1515-22. 2008
    b>Zinc (Zn) is an essential heavy metal that is incorporated into a number of human Zn metalloproteins. Zn plays important roles in nucleic acid metabolism, cell replication, and tissue repair and growth...
  85. ncbi The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility
    I M W Ebisch
    Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Hum Reprod Update 13:163-74. 2007
    ..b>Zinc has also been implicated in testicular development, sperm maturation and testosterone synthesis...
  86. pmc Characterization of a Mycobacterium tuberculosis ESX-3 conditional mutant: essentiality and rescue by iron and zinc
    Agnese Serafini
    Department of Histology, Microbiology, and Medical Biotechnologies, University of Padua, Via Gabelli 63, 35121 Padua, Italy
    J Bacteriol 191:6340-4. 2009
    ..bovis BCG attenuation. Another T7SS, ESX-3, has been previously shown to be transcriptionally controlled by the zinc uptake repressor (Zur) and by the iron-dependent transcriptional repressor (IdeR), suggesting that it might be ..
  87. pmc Zinc salts inactivate clinical isolates of herpes simplex virus in vitro
    M Arens
    The Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Microbiol 38:1758-62. 2000
    Using a standard plaque assay and clinical isolates of herpes simplex virus (HSV), we have tested the ability of zinc salts to inactivate HSV...
  88. ncbi Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14
    K M Taylor
    Tenovus Cancer Research Centre, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3XF, UK
    FEBS Lett 579:427-32. 2005
    Here, we report the first investigation of a novel member of the LZT (LIV-1 subfamily of ZIP zinc Transporters) subfamily of zinc influx transporters...
  89. pmc Zap1p, a metalloregulatory protein involved in zinc-responsive transcriptional regulation in Saccharomyces cerevisiae
    H Zhao
    Department of Biochemistry and Molecular Biology, University of Minnesota Duluth, 55812, USA
    Mol Cell Biol 17:5044-52. 1997
    b>Zinc ion homeostasis in Saccharomyces cerevisiae is controlled primarily through the transcriptional regulation of zinc uptake systems in response to intracellular zinc levels...
  90. ncbi Nerve growth factor in different crystal forms displays structural flexibility and reveals zinc binding sites
    D R Holland
    Institute of Molecular Biology, Howard Hughes Medical Institute, Eugene, OR
    J Mol Biol 239:385-400. 1994
    ..1) with zinc acetate concentrations of 1 mM and 100 mM, respectively...
  91. ncbi Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 years in an urban, low-income population in Bangladesh: randomised controlled trial
    W Abdullah Brooks
    The Centre for Health and Population Research, International Centre for Diarrhoea Disease Research, Mohakhali Dhaka 1000, Bangladesh
    Lancet 366:999-1004. 2005
    ..Most deaths occur during infancy and in developing countries. Daily regimens of zinc have been reported to prevent acute lower respiratory tract infection and diarrhoea, and to reduce child mortality...
  92. pmc Visualization of transmitter release with zinc fluorescence detection at the mouse hippocampal mossy fibre synapse
    Jing Qian
    Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Physiol 566:747-58. 2005
    ..Here we developed a technique to directly assess exocytosis by measuring vesicular zinc release with the zinc-sensitive dye FluoZin-3 at the hippocampal mossy fibre (MF) synapse...
  93. ncbi New insights into the role of zinc in the respiratory epithelium
    A Q Truong-Tran
    Department of Medicine, University of Adelaide, The Queen Elizabeth Hospital, Woodville, South Australia, Australia
    Immunol Cell Biol 79:170-7. 2001
    Over the past 30 years, many researchers have demonstrated the critical role of zinc (Zn), a group IIb metal, in diverse physiological processes, such as growth and development, maintenance and priming of the immune system, and tissue ..
  94. ncbi Antidepressant-like properties of zinc in rodent forced swim test
    B Kroczka
    Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Brain Res Bull 55:297-300. 2001
    The effects of zinc, the N-methyl-D-aspartate glutamate receptor inhibitor, were studied in mice and rats using the forced swim test...
  95. ncbi The ZRT2 gene encodes the low affinity zinc transporter in Saccharomyces cerevisiae
    H Zhao
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Minnesota, Duluth, Minnesota 55812, USA
    J Biol Chem 271:23203-10. 1996
    b>Zinc accumulation in Saccharomyces cerevisiae occurs through either of two uptake systems. A high affinity system is active in zinc-limited cells, and the ZRT1 gene encodes the transporter protein of this system...
  96. ncbi An architectural framework that may lie at the core of the postsynaptic density
    Marisa K Baron
    Department of Chemistry and Biochemistry, Molecular Biology Institute, University of California, Los Angeles, 611 Charles E Young Drive East, Los Angeles, CA 90095 1570, USA
    Science 311:531-5. 2006
    ..Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex...
  97. doi Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse
    Yang Z Huang
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 57:546-58. 2008
    ..deletion of its prototypic neurotrophin ligands led us to hypothesize that a non-neurotrophin, the divalent cation zinc, can transactivate TrkB...
  98. doi MTP1-dependent Zn sequestration into shoot vacuoles suggests dual roles in Zn tolerance and accumulation in Zn-hyperaccumulating plants
    Jeffery L Gustin
    Center for Plant Environmental Stress Physiology, Purdue University, West Lafayette, IN, USA
    Plant J 57:1116-27. 2009
    ..goesingense play a role in both Zn tolerance and enhanced Zn uptake and accumulation, via the activation of a systemic Zn deficiency response...
  99. doi Zinc pyrithione induces cellular stress signaling and apoptosis in Hep-2 cervical tumor cells: the role of mitochondria and lysosomes
    Emil Rudolf
    Department of Medical Biology and Genetics, Faculty of Medicine in Hradec Kralove, Charles University in Prague, 500 01 Hradec Kralove I, Czech Republic
    Biometals 23:339-54. 2010
    Increased intracellular free zinc concentrations are associated with activation of several stress signaling pathways, specific organelle injury and final cell death...
  100. ncbi Immune-enhancing role of vitamin C and zinc and effect on clinical conditions
    Eva S Wintergerst
    Bayer Consumer Care Ltd, Basel, Switzerland
    Ann Nutr Metab 50:85-94. 2006
    ..Likewise, zinc undernutrition or deficiency was shown to impair cellular mediators of innate immunity such as phagocytosis, ..
  101. doi Design, synthesis and biological application of chemical probes for bio-imaging
    Kazuya Kikuchi
    Graduate School of Engineering, Osaka University, 2 1 Yamada oka, Suita City, Osaka 565 0871, Japan
    Chem Soc Rev 39:2048-53. 2010
    ..The MRI signal of the intrinsic (19)F is hardly detectable. A novel design strategy for (19)F MRI probes in detecting protease activity is described...

Research Grants81

  1. ZINC COORDINATION AND REGULATION OF ZINC METALLOPROTEINS
    DAVID GIEDROC; Fiscal Year: 2003
    ..continued support for ongoing studies of the structure, bioinorganic chemistry and allosteric regulation by zinc of selected zinc metalloregulatory transcription factors derived from mammalian and prokaryotic organisms which ..
  2. FUNCTIONAL ANALYSIS OF A LEAD/CADMIUM/ZINC ATPASE
    Bharati Mitra; Fiscal Year: 2010
    ..These pumps maintain homeostasis of essential trace metals like copper, zinc, cobalt and nickel, and mediate resistance to toxic metals such as lead, cadmium and silver...
  3. REGULATION OF CELLULAR ZINC HOMEOSTASIS
    David Eide; Fiscal Year: 2009
    b>Zinc is an essential nutrient because of the important roles this metal plays as a catalytic and structural cofactor...
  4. Malaria in Pregnancy: Nutrition and Immunologic Effects
    Wafaie W Fawzi; Fiscal Year: 2010
    ..Vitamin A and zinc deficiencies are specific factors which can modulate the clinical course of malaria and exacerbate associated ..
  5. Arsenic-enhanced skin carcinogenesis by UV radiation
    Ke Liu; Fiscal Year: 2009
    ..Proposed protein targets of arsenite include Poly (ADP-ribose) polymerase (PARP)- 1, a protein with two C3H1 zinc finger motifs in the DNA binding domain and one C4 zinc binding motif responsible for DNA-dependent catalytic ..
  6. Zinc inhibition of endotoxemia in alcoholic liver injury
    Zhanxiang Zhou; Fiscal Year: 2009
    b>Zinc inhibition of endotoxemia in alcoholic liver injury Abstract Alcoholic liver disease (ALD) is an important health problem, but an FDA-approved effective therapy is not available...
  7. FUNCTIONAL ANALYSIS OF A LEAD/CADMIUM/ZINC ATPASE
    Bharati Mitra; Fiscal Year: 2007
    ..These pumps maintain homeostasis of essential trace metals like copper, zinc, cobalt and nickel, and mediate resistance to toxic metals such as lead, cadmium and silver...
  8. Zinc inhibition of endotoxemia in alcoholic liver injury
    Zhanxiang Zhou; Fiscal Year: 2010
    b>Zinc inhibition of endotoxemia in alcoholic liver injury Abstract Alcoholic liver disease (ALD) is an important health problem, but an FDA-approved effective therapy is not available...
  9. Investigation of Zinc Neurochemistry by Optical Sensing and MRI
    Stephen J Lippard; Fiscal Year: 2010
    ..The long-term goal of this research is to devise molecular sensors for binding, visualizing, and quantifying mobile zinc in neurobiological systems...
  10. Genomic analysis of pediatric SIRS and septic shock
    Hector Wong; Fiscal Year: 2009
    ..The competitive revision seeks to develop a point-of-care platform for measuring serum zinc concentrations in children with septic shock, the "zinc chip...
  11. Effect of Zinc in Attaching and Effacing E. coli Infection
    JOHN K contact CRANE; Fiscal Year: 2010
    b>Zinc has been shown to reduce the duration and severity of diarrheal diseases in studies of poor children on several continents...
  12. Structural Investigation of Allosteric Regulation in Bacterial Carbonic Anhydrase
    JEFF CRONK; Fiscal Year: 2007
    ..and physiological importance, the interconversion of carbon dioxide and bicarbonate ion CO2 + H2O - All CAs are zinc-dependent enzymes and a well-established mechanistic paradigm requires the coordination of substrate to the ..
  13. Human Zinc Transporter Zip 13 and Cellular Zinc Homeostasis
    Joel Walker; Fiscal Year: 2007
    b>Zinc is an essential nutrient needed for many cellular processes, however, excess zinc leads to cell death...
  14. Towards tuberculosis control: pyrazinamide susceptibility and resistant mechanism
    Patricia Sheen; Fiscal Year: 2007
    ..site, will revert its PZase activity, turning to a PZA-sensitive phenotype, under high concentrations of zinc ions, the probable cofactor...
  15. REGULATION OF CELLULAR ZINC HOMEOSTASIS
    David J Eide; Fiscal Year: 2010
    b>Zinc is an essential nutrient because of the important roles this metal plays as a catalytic and structural cofactor...
  16. SYNTHETIC ANALOGUES OF ZINC ENZYMES
    Gerard Parkin; Fiscal Year: 2003
    DESCRIPTION: (Adapted from applicant's abstract) Zinc is widely recognized as being essential to all forms of life, and in particular that of humans...
  17. THE ROLE OF ZINC FINGER GENES IN HEMATOPOIESIS
    Sinisa Dovat; Fiscal Year: 2003
    ..Ikaros encodes a zinc finger protein whose expression is restricted to hematopoietic cells...
  18. DIETARY ZINC-ITS EFFECTS ON THE IMMUNE RESPONSE
    Pamela Fraker; Fiscal Year: 2007
    The zinc deficient mouse (ZD) is a valuable model for elucidating the molecular and biochemical changes made by the immune system to provide a core of host defense in the face of suboptimal nutriture...