Genomes and Genes
Summary: A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Publications342 found, 100 shown here
- Zinc in human health: effect of zinc on immune cellsAnanda S Prasad
Wayne State University School of Medicine, Detroit, Michigan 48201, United States of America
Mol Med 14:353-7. 2008Although the essentiality of zinc for plants and animals has been known for many decades, the essentiality of zinc for humans was recognized only 40 years ago in the Middle East...
- Zinc homeostasis and signaling in health and diseases: Zinc signalingToshiyuki Fukada
Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, 230 0045, Japan
J Biol Inorg Chem 16:1123-34. 2011The essential trace element zinc (Zn) is widely required in cellular functions, and abnormal Zn homeostasis causes a variety of health problems that include growth retardation, immunodeficiency, hypogonadism, and neuronal and sensory ..
- Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's diseaseJames A Duce
Mental Health Research Institute, The University of Melbourne, Parkville, Victoria 3052, Australia
Cell 142:857-67. 2010..Abnormal exchange of cortical zinc may link amyloid pathology with neuronal iron accumulation in AD.
- Metallo-beta-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamilyCarine Bebrone
Center for Protein Engineering Biological Macromolecules, University of Liege, Allée du 6 Août B6, Sart Tilman 4000 Liège, Belgium
Biochem Pharmacol 74:1686-701. 2007..In the last few years, many new zinc beta-lactamases have been described and several pathogens are now known to synthesize members of this class...
- Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasisC E Outten
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
Science 292:2488-92. 2001Intracellular zinc is thought to be available in a cytosolic pool of free or loosely bound Zn(II) ions in the micromolar to picomolar range...
- A NAC Gene regulating senescence improves grain protein, zinc, and iron content in wheatCristobal Uauy
Department of Plant Sciences, University of California, One Shields Avenue, Davis, CA 95616, USA
Science 314:1298-301. 2006..here the positional cloning of Gpc-B1, a wheat quantitative trait locus associated with increased grain protein, zinc, and iron content...
- Zinc finger proteins: new insights into structural and functional diversityJ H Laity
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Curr Opin Struct Biol 11:39-46. 2001b>Zinc finger proteins are among the most abundant proteins in eukaryotic genomes...
- Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial AbetaPaul A Adlard
Oxidation Biology Laboratory, The Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia
Neuron 59:43-55. 2008..The speed of recovery of the animals underscores the acutely reversible nature of the cognitive deficits associated with transgenic models of AD...
- Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementationMichal Sheffer
Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100, Israel
Oncotarget 2:1191-202. 2011..b>Zinc supplementation has been shown to counteract the hypoxic phenotype in cancer cells, in vitro and in vivo, hence, ..
- miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cellsBrittany L Mihelich
Department of Pathology, University of Illinois, Chicago, Illinois 60612, USA
J Biol Chem 286:44503-11. 2011Decreased zinc levels are a hallmark of prostate cancer tumors as zinc uniquely concentrates in healthy prostate tissue...
- The neurophysiology and pathology of brain zincStefano L Sensi
Department of Neuroscience and Imaging, Molecular Neurology Unit, CeSI Center for Excellence on Aging, University G D Annunzio, Chieti 66013, Italy
J Neurosci 31:16076-85. 2011Our understanding of the roles played by zinc in the physiological and pathological functioning of the brain is rapidly expanding...
- Metallothionein: the multipurpose proteinP Coyle
Division of Clinical Biochemistry, Institute of Medical and Veterinary Science, Adelaide, SA
Cell Mol Life Sci 59:627-47. 2002..Use of mice with altered gene expression has enhance our understanding of the multifaceted role of MT, emphasised in this review...
- Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trialsKenneth H Brown
Program in International Nutrition and the Department of Nutrition, University of California, Davis 95616, USA
Am J Clin Nutr 75:1062-71. 2002Multiple studies have been carried out to assess the effect of zinc supplementation on children's growth. The results of these studies are inconsistent, and the factors responsible for these varied outcomes are unknown.
- Zinc in the physiology and pathology of the CNSStefano L Sensi
Department of Basic and Applied Medical Science, Molecular Neurology Unit, CeSI Center for Excellence on Aging, University G dAnnunzio, Chieti, 66013, Italy
Nat Rev Neurosci 10:780-91. 2009The past few years have witnessed dramatic progress on all frontiers of zinc neurobiology...
- Molecular mechanisms of metal hyperaccumulation in plantsNathalie Verbruggen
Universite Libre de Bruxelles, B 1050 Brussels, Belgium
New Phytol 181:759-76. 2009..This review presents key aspects of our current understanding of plant metal – in particular cadmium (Cd),nickel (Ni) and zinc (Zn) – hyperaccumulation.
- Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cellsWeidong Wu
Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Biol Chem 278:28258-63. 2003..Pretreatment of the cells with a proteasome inhibitor significantly blocked zinc-induced reduction of PTEN protein as well as the increase in Akt phosphorylation, implicating the involvement of ..
- Mycobacterial p(1)-type ATPases mediate resistance to zinc poisoning in human macrophagesHélène Botella
Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
Cell Host Microbe 10:248-59. 2011..genes encoding heavy metal efflux P-type ATPases CtpC, CtpG, and CtpV, and host cell metallothioneins and zinc exporter ZnT1, were induced during infection...
- Iron, zinc and copper in the Alzheimer's disease brain: a quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinionMatthew Schrag
Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, CA, USA
Prog Neurobiol 94:296-306. 2011..Although questioned by some, brain copper, zinc, and particularly iron overload are widely accepted features of AD which have led to the hypothesis that oxidative ..
- Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureusThomas E Kehl-Fie
Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Cell Host Microbe 10:158-64. 2011By sequestering manganese and zinc, the neutrophil protein calprotectin plays a crucial role in host defense against bacterial and fungal pathogens. However, the essential processes disrupted by calprotectin remain unknown...
- Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugsRosa Puca
National Cancer Institute Regina Elena, Rome, Italy
Cell Cycle 10:1679-89. 2011..inhibition of DNA binding and transcriptional activities that correlate with increased chemoresistance, and that zinc rescues wild-type p53 activity...
- The adaptive response to dietary zinc in mice involves the differential cellular localization and zinc regulation of the zinc transporters ZIP4 and ZIP5Jodi Dufner-Beattie
Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160 7421, USA
J Biol Chem 279:49082-90. 2004The ZIP5 gene encodes a protein closely related to ZIP4, a zinc transporter mutated in the human genetic disorder acrodermatitis enteropathica...
- Zinc and cognitive developmentS Bhatnagar
All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
Br J Nutr 85:S139-45. 2001..b>Zinc deficiency may affect cognitive development by alterations in attention, activity, neuropsychological behavior and ..
- A fungal family of transcriptional regulators: the zinc cluster proteinsSarah MacPherson
Department of Microbiology and Immunology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada H3A 1A
Microbiol Mol Biol Rev 70:583-604. 2006The trace element zinc is required for proper functioning of a large number of proteins, including various enzymes. However, most zinc-containing proteins are transcription factors capable of binding DNA and are named zinc finger proteins...
- The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in miceJodi Dufner-Beattie
Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160 7421, USA
J Biol Chem 278:33474-81. 2003The human ZIP4 gene (SLC39A4) is a candidate for the genetic disorder of zinc metabolism acrodermatitis enteropathica. To understand its role in zinc homeostasis, we examined the function and expression of mouse ZIP4...
- Mechanisms of nutrient modulation of the immune responseSusanna Cunningham-Rundles
Host Defenses Program, Department of Pediatrics, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY, USA
J Allergy Clin Immunol 115:1119-28; quiz 1129. 2005Lack of adequate macronutrients or selected micronutrients, especially zinc, selenium, iron, and the antioxidant vitamins, can lead to clinically significant immune deficiency and infections in children...
- Mammalian zinc transport, trafficking, and signalsRobert J Cousins
Nutritional Genomics Laboratory, Food Science and Human Nutrition Department, Center for Nutritional Sciences, University of Florida, Gainesville, Florida 32611 0370, USA
J Biol Chem 281:24085-9. 2006
- Counting the zinc-proteins encoded in the human genomeClaudia Andreini
Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019 Sesto Fiorentino, Italy
J Proteome Res 5:196-201. 2006..proposes a strategy to answer the question of how many and which proteins encoded in the human genome may require zinc for their physiological function...
- Metal chelation and inhibition of bacterial growth in tissue abscessesBrian D Corbin
Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Science 319:962-5. 2008..These results demonstrate that calprotectin is a critical factor in the innate immune response to infection and define metal chelation as a strategy for inhibiting microbial growth inside abscessed tissue...
- Mammalian zinc transporters: nutritional and physiologic regulationLouis A Lichten
Nutritional Genomics Laboratory, Food Science and Human Nutrition Department and Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611 2710, USA
Annu Rev Nutr 29:153-76. 2009Research advances defining how zinc is transported into and out of cells and organelles have increased exponentially within the past five years...
- Low micromolar zinc accelerates the fibrillization of human tau via bridging of Cys-291 and Cys-322Zhong Ying Mo
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
J Biol Chem 284:34648-57. 2009..There is considerable evidence showing that zinc, as an essential element that is highly concentrated in brain, is linked to the development or progression of these ..
- Zinc coordination sphere in biochemical zinc sitesD S Auld
Center for Biochemical and Biophysical Sciences and Medicine and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Biometals 14:271-313. 2001b>Zinc is known to be indispensable to growth and development and transmission of the genetic message. It does this through a remarkable mosaic of zinc binding motifs that orchestrate all aspects of metabolism...
- Cu/Zn ratios are associated with nutritional status, oxidative stress, inflammation, and immune abnormalities in patients on peritoneal dialysisChih Hung Guo
Institute of Biomedical Nutrition, Hung Kuang University, Taichung 433, Taiwan, ROC
Clin Biochem 44:275-80. 2011We evaluated the relationship of the plasma copper/zinc (Cu/Zn) ratio with nutritional status, inflammation, oxidative stress, and immune function in peritoneal dialysis patients.
- Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4Marc Hanikenne
Max Planck Institute of Molecular Plant Physiology, D 14476 Potsdam, Germany
Nature 453:391-5. 2008..A. halleri naturally accumulates and tolerates leaf concentrations as high as 2.2% zinc and 0.28% cadmium in dry biomass. On the basis of transcriptomics studies, metal hyperaccumulation in A...
- Molecular and genetic features of zinc transporters in physiology and pathogenesisToshiyuki Fukada
Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
Metallomics 3:662-74. 2011b>Zinc (Zn) is a vital element...
- Intracellular zinc release-activated ERK-dependent GSK-3β-p53 and Noxa-Mcl-1 signaling are both involved in cardiac ischemic-reperfusion injuryC L Lin
Institute of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan
Cell Death Differ 18:1651-63. 2011..Thus, acute upstream Zn(2+)(i) chelation at the start of reperfusion and the use of natural products, that is, flavonoids, may be beneficial in the treatment of cardiac I/R injury...
- Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase responseJuan P Liuzzi
Nutritional Genomics Laboratory, Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611, USA
Proc Natl Acad Sci U S A 102:6843-8. 2005..The latter involves regulation of the iron transporter ferroportin 1 by hepcidin. The mechanism of reduced plasma zinc is not known...
- Think zinc: New roles for zinc in the control of insulin secretionGuy A Rutter
Department of Cell Biology, Imperial College London, UK
Islets 2:49-50. 2010Genome wide association studies have identified the islet-restricted zinc transporter ZnT8 (SLC30A8) as a likely player in the control of insulin secretion and the risk of developing type 2 diabetes...
- The missing zinc: p53 misfolding and cancerStewart N Loh
Department of Biochemistry and Molecular Biology, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
Metallomics 2:442-9. 2010The p53 tumor suppressor is a transcription factor that contains a single zinc ion near its DNA binding interface. Zn(2+) is required for site-specific DNA binding and proper transcriptional activation...
- Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variantsTamara J Nicolson
Section of Cell Biology, Division of Medicine, Imperial College London, London, U K
Diabetes 58:2070-83. 2009b>Zinc ions are essential for the formation of hexameric insulin and hormone crystallization...
- Study on clinical and biochemical toxicity biomarkers in a zinc-lead mine workersAli Akbar Malekirad
Science and Research Branch, Islamic Azad University IAU, Tehran, Iran
Toxicol Ind Health 26:331-7. 2010The aim of this study was to determine oxidative stress status as well as blood lead (Pb) and zinc (Zn) levels and clinical markers in workers of a Zn-Pb mine...
- Zinc: role in immunity, oxidative stress and chronic inflammationAnanda S Prasad
Department of Internal Medicine, Division of Hematology Oncology, Wayne State University, School of Medicine, Detroit, Michigan, USA
Curr Opin Clin Nutr Metab Care 12:646-52. 2009b>Zinc is essential for multiple cellular functions including immunity. Many investigators have used zinc supplementation in an attempt to affect the outcome of various diseases...
- HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradationLavinia Nardinocchi
Department of Experimental Oncology, Molecular Oncogenesis Laboratory, National Cancer Institute Regina Elena, Rome, Italy
Aging (Albany NY) 3:33-43. 2011..Inhibition of HIF-1α by siRNA, HIF-1α-dominant negative or by zinc re-established the HIPK2 levels and the p53-mediated chemosensitivity in tumor cells...
- The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathwaysToshiyuki Fukada
Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Tsurumi, Yokohama, Kanagawa, Japan
PLoS ONE 3:e3642. 2008b>Zinc (Zn) is an essential trace element and it is abundant in connective tissues, however biological roles of Zn and its transporters in those tissues and cells remain unknown.
- International Zinc Nutrition Consultative Group (IZiNCG) technical document #1. Assessment of the risk of zinc deficiency in populations and options for its controlKenneth H Brown
Program in International Nutrition, University of California, Davis, USA
Food Nutr Bull 25:S99-203. 2004
- The mouse acrodermatitis enteropathica gene Slc39a4 (Zip4) is essential for early development and heterozygosity causes hypersensitivity to zinc deficiencyJodi Dufner-Beattie
Department of Biochemistry and Molecular Biology, University of Virginia School of Medicine, PO Box 800734, Charlottesville, VA 22908, USA
Hum Mol Genet 16:1391-9. 2007The human Zip4 gene (Slc39a4) is mutated in the rare recessive genetic disorder of zinc metabolism acrodermatitis enteropathica, but the physiological functions of Zip4 are not well understood...
- Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretionN Wijesekara
Department of Physiology, University of Toronto, 1 King s College Circle Room 3352, Toronto, ON, Canada M5S 1A8
Diabetologia 53:1656-68. 2010b>Zinc is highly concentrated in pancreatic beta cells, is critical for normal insulin storage and may regulate glucagon secretion from alpha cells...
- A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapsesAtul Deshpande
Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697, USA
J Neurosci 29:4004-15. 2009..The zinc-binding 8-OH-quinoline clioquinol markedly reduced AbetaO synaptic targeting, which was also reduced in brain ..
- Roles of zinc and zinc signaling in immunity: zinc as an intracellular signaling moleculeToshio Hirano
Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
Adv Immunol 97:149-76. 2008b>Zinc (Zn) is an essential nutrient required for cell growth, differentiation, and survival, and its deficiency causes growth retardation, immunodeficiency, and other health problems...
- Contributions of Zur-controlled ribosomal proteins to growth under zinc starvation conditionsScott E Gabriel
Department of Microbiology, Cornell University, Ithaca, NY 14853 8101, USA
J Bacteriol 191:6116-22. 2009Maintaining intracellular zinc levels is critical, because zinc serves as a cofactor for many required enzymes and is toxic in excess...
- Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidenceJian Dong
Department of Biochemistry, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
Biochemistry 42:2768-73. 2003..The results also reveal a direct chemical basis for oxidative damage caused by amyloid-beta protein in AD...
- Preventive zinc supplementation among infants, preschoolers, and older prepubertal childrenKenneth H Brown
Department of Nutrition, University of California, Davis, California 95616, USA
Food Nutr Bull 30:S12-40. 2009b>Zinc supplementation trials carried out among children have produced variable results, depending on the specific outcomes considered and the initial characteristics of the children who were enrolled...
- Zinc in plantsMartin R Broadley
Plant Sciences Division, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, UK
New Phytol 173:677-702. 2007b>Zinc (Zn) is an essential component of thousands of proteins in plants, although it is toxic in excess...
- A comparison of the Thlaspi caerulescens and Thlaspi arvense shoot transcriptomesJohn P Hammond
Warwick HRI, University of Warwick, Wellesbourne, Warwick CV35 9EF, UK
New Phytol 170:239-60. 2006..of a robust method to profile and compare the transcriptomes of two nonmodel plant species, Thlaspi caerulescens, a zinc (Zn) hyperaccumulator, and Thlaspi arvense, a nonhyperaccumulator, using Affymetrix Arabidopsis thaliana ATH1-..
- Synaptically released zinc triggers metabotropic signaling via a zinc-sensing receptor in the hippocampusLimor Besser
Department of Morphology, Ben Gurion University, Beer Sheva 84105, Israel
J Neurosci 29:2890-901. 2009..Our results describe a unique role for synaptic Zn(2+) acting as the physiological ligand of a metabotropic receptor and provide a novel pathway by which synaptic Zn(2+) can regulate neuronal function...
- The ZnuABC high-affinity zinc uptake system and its regulator Zur in Escherichia coliS I Patzer
Mikrobiologie Membranphysiologie, Universitat Tubingen, Germany
Mol Microbiol 28:1199-210. 1998..This high-affinity transport was energized by ATP. The genes were named znuACB (for zinc uptake; former name yebLMI) and localized at 42 min on the genetic map of E. coli...
- Use of national food balance data to estimate the adequacy of zinc in national food supplies: methodology and regional estimatesSara E Wuehler
Department of Nutrition and Program in International Nutrition, University of California Davis, Davis, CA 95616, USA
Public Health Nutr 8:812-9. 2005Adequate zinc nutriture is critically important for human health, but the development of programmes to control zinc deficiency is limited by the lack of reliable information on population zinc status...
- Exacerbation of diabetes-induced testicular apoptosis by zinc deficiency is most likely associated with oxidative stress, p38 MAPK activation, and p53 activation in miceYuguang Zhao
Cancer Center, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China
Toxicol Lett 200:100-6. 2011Since diabetes induces testicular oxidative damage and cell death, and zinc (Zn) plays an important role in the spermatogenesis, the objective of the present study was to define the effects of Zn deficiency on diabetes-induced testicular ..
- New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zincC Corona
Molecular Neurology Unit, Center of Excellence on Aging CeSI, Chieti, Italy
Cell Death Dis 2:e176. 2011..for the disease is the development of an unbalanced homeostasis of two signaling cations: calcium (Ca(2+)) and zinc (Zn(2+))...
- Level of trace elements (copper, zinc, magnesium and selenium) and toxic elements (lead and mercury) in the hair and nail of children with autismMalarveni Damodaran Lakshmi Priya
Department of Biochemistry, Bharathi Women s College, Chennai, 600 108 Tamil Nadu, India
Biol Trace Elem Res 142:148-58. 2011..Therefore, the purpose of the present study was to assess the levels of trace elements like copper (Cu), zinc (Zn), magnesium (Mg), and selenium (Se) and toxic elements like mercury (Hg), and lead (Pb) in the hair and nail ..
- Zinc restriction during different periods of life: influence in renal and cardiovascular diseasesAnalía Lorena Tomat
Catedra de Fisiologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, IQUIMEFA CONICET, Junin 956, Piso 7, Ciudad Autonoma de Buenos Aires, Argentina 1113
Nutrition 27:392-8. 2011..b>Zinc is a widely studied microelement in infant feeding because it is a component of several enzymes involved in ..
- Zinc availability regulates exit from meiosis in maturing mammalian oocytesAlison M Kim
Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
Nat Chem Biol 6:674-81. 2010..Here we describe major changes in the zinc physiology of the mammalian oocyte as it matures and initiates embryonic development...
- Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RINGAllan D Capili
Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
J Mol Biol 340:1117-29. 2004..Notably, RING2 binds only one zinc atom per monomer rather than two and uses a different hydrophobic network to that of classical RINGs...
- Histidine protects against zinc and nickel toxicity in Caenorhabditis elegansJohn T Murphy
Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, United States of America
PLoS Genet 7:e1002013. 2011b>Zinc is an essential trace element involved in a wide range of biological processes and human diseases. Zinc excess is deleterious, and animals require mechanisms to protect against zinc toxicity...
- Impact of the discovery of human zinc deficiency on healthAnanda S Prasad
Wayne State University School of Medicine, 1122 Elliman Bldg, 421 East Canfield, Detroit, MI 48201, USA
J Am Coll Nutr 28:257-65. 2009The essentiality of zinc was recognized 46 years ago. Zinc deficiency resulting in growth retardation, hypogonadism, immune dysfunction and cognitive impairment affects nearly 2 billion subjects in the developing world...
- Zinc is a novel intracellular second messengerSatoru Yamasaki
Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan
J Cell Biol 177:637-45. 2007b>Zinc is an essential trace element required for enzymatic activity and for maintaining the conformation of many transcription factors; thus, zinc homeostasis is tightly regulated...
- Zinc ions promote Alzheimer Abeta aggregation via population shift of polymorphic statesYifat Miller
Center for Cancer Research Nanobiology Program, National Cancer Institute Frederick, Frederick, MD 21702, USA
Proc Natl Acad Sci U S A 107:9490-5. 2010..factor in Alzheimer's disease etiology is enrichment of Zn(2+) in aggregates, and there are data suggesting that zinc promotes aggregation, how Zn(2+)-Abeta coordination promotes aggregation is elusive...
- Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturationAndreas M Grabrucker
Institute of Anatomy and Cell Biology, University of Ulm, Ulm, Germany
EMBO J 30:569-81. 2011..postsynapses and comparing this to shRNA-mediated knockdown, we could demonstrate that only the overexpression of zinc-sensitive ProSAP1/Shank2 or ProSAP2/Shank3 leads to increased synapse density, although all of them cause a ..
- The zinc dyshomeostasis hypothesis of Alzheimer's diseaseTravis J A Craddock
Department of Physics, University of Alberta, Edmonton, Alberta, Canada
PLoS ONE 7:e33552. 2012..The mechanisms linking Aβ and NFT pathologies in AD are unknown. Here, we propose that sequestration of zinc by Aβ-amyloid deposits (Aβ oligomers and plaques) not only drives Aβ aggregation, but also disrupts zinc ..
- Effect of supplementation with zinc and other micronutrients on malaria in Tanzanian children: a randomised trialJacobien Veenemans
Wageningen University, Cell Biology and Immunology Group, Wageningen, The Netherlands
PLoS Med 8:e1001125. 2011It is uncertain to what extent oral supplementation with zinc can reduce episodes of malaria in endemic areas. Protection may depend on other nutrients...
- Regulation of T cell receptor signaling by activation-induced zinc influxMingcan Yu
Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
J Exp Med 208:775-85. 2011b>Zinc is a trace element that is essential for innate and adaptive immune responses. In addition to being a structural element of many proteins, zinc also functions as a neurotransmitter and an intracellular messenger...
- Zinc supplement greatly improves the condition of parkin mutant DrosophilaNidhi Saini
Institute of Molecular Life Sciences, University of Zurich, Switzerland
Biol Chem 391:513-8. 2010..In a Drosophila disease model lacking Parkin (park(25) null mutant), we tested the effect of zinc supplementation. Zinc is an essential trace metal and a component of many enzymes and transcriptional regulators...
- The essential toxin: impact of zinc on human healthLaura M Plum
Institute of Immunology, Medical Faculty, RWTH Aachen University, Pauwelstrasse 30, 52074 Aachen, Germany
Int J Environ Res Public Health 7:1342-65. 2010Compared to several other metal ions with similar chemical properties, zinc is relatively harmless. Only exposure to high doses has toxic effects, making acute zinc intoxication a rare event...
- The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitationH Zhao
Department of Biochemistry and Molecular Biology, School of Medicine, University of Minnesota, Duluth 55812, USA
Proc Natl Acad Sci U S A 93:2454-8. 1996The yeast Saccharomyces cerevisiae has two separate systems for zinc uptake. One system has high affinity for substrate and is induced in zinc-deficient cells...
- Zinc enhances long-term potentiation through P2X receptor modulation in the hippocampal CA1 regionRamón A Lorca
Laboratorio de Neurociencias, Departamento de Biologia, Facultad de Quimica y Biologia, Universidad de Santiago de Chile, Santiago 9170022, Chile
Eur J Neurosci 33:1175-85. 2011..Although it is not yet clear which purinergic receptor subtype(s) is responsible for these effects on LTP, the data presented here suggest that P2X₄ but not P2X₇ is involved...
- Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in miceK Lemaire
Gene Expression Unit, Department Molecular Cell Biology, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
Proc Natl Acad Sci U S A 106:14872-7. 2009b>Zinc co-crystallizes with insulin in dense core secretory granules, but its role in insulin biosynthesis, storage and secretion is unknown...
- Phase perfection in zinc Blende and Wurtzite III-V nanowires using basic growth parametersHannah J Joyce
Department of Electronic Materials Engineering, Research School of Physics and Engineering, The Australian National University, Canberra, ACT 0200, Australia
Nano Lett 10:908-15. 2010..Phase purity is achieved without sacrificing important specifications of diameter and dopant levels. Pure zinc blende nanowires, free of twin defects, were achieved using a low growth temperature coupled with a high V/III ..
- Tooth hardness increases with zinc-content in mandibles of young adult leaf-cutter antsRobert M S Schofield
Department of Physics, University of Oregon, Eugene, OR 97403, USA
Naturwissenschaften 89:579-83. 2002..91). We suggest that young adults rarely cut leaves partly because their mandibles are not yet rich in Zn. Zinc enrichment (along with enrichment by other heavy metals and halogens) may play an unrecognized role in the ..
- Cytotoxic effects of intra and extracellular zinc chelation on human breast cancer cellsMohammad Hashemi
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Eur J Pharmacol 557:9-19. 2007b>Zinc is an essential trace element with cofactor functions in a large number of proteins of intermediary metabolism, hormone secretion pathways, immune defence mechanisms, and as a cofactor of transcription factors it is also involved in ..
- Effects of cadmium and zinc on plasma levels of growth hormone, insulin-like growth factor I, and insulin-like growth factor-binding protein 3Sebahat Turgut
Department of Physiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey
Biol Trace Elem Res 108:197-204. 2005Humans are constantly exposed to cadmium (Cd) as a result of the increase in air pollution and cigaret use. Zinc (Zn), which is an essential element for the metabolism of and the constituent of many enzymes, causes growth retardation in ..
- Effects of zinc on plasma lipoprotein cholesterol concentrations in humans: a meta-analysis of randomised controlled trialsMeika Foster
Discipline of Nutrition and Metabolism, School of Molecular and Microbial Biosciences, University of Sydney NSW 2006, Australia
Atherosclerosis 210:344-52. 2010Studies in humans and animals suggest that zinc has the potential to affect lipoprotein metabolism and hence impact cardiovascular disease risk.
- Zinc deficiency induces depression-like symptoms in adult ratsNadine M Tassabehji
Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, Florida 32306 4340, United States
Physiol Behav 95:365-9. 2008There is mounting evidence suggesting a link between serum zinc levels and clinical depression...
- Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction but not the immediate-type reactionKeigo Nishida
Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
J Exp Med 206:1351-64. 2009b>Zinc (Zn) is an essential nutrient and its deficiency causes immunodeficiency. However, it remains unknown how Zn homeostasis is regulated in mast cells and if Zn transporters are involved in allergic reactions...
- Transient fluctuations of intracellular zinc ions in cell proliferationYuan Li
Division of Human Nutrition, Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555, USA
Exp Cell Res 315:2463-70. 2009b>Zinc is essential for cell proliferation, differentiation, and viability. When zinc becomes limited for cultured cells, DNA synthesis ceases and the cell cycle is arrested...
- Intracellular zinc homeostasis and zinc signalingMasaaki Murakami
Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
Cancer Sci 99:1515-22. 2008b>Zinc (Zn) is an essential heavy metal that is incorporated into a number of human Zn metalloproteins. Zn plays important roles in nucleic acid metabolism, cell replication, and tissue repair and growth...
- The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertilityI M W Ebisch
Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Hum Reprod Update 13:163-74. 2007..b>Zinc has also been implicated in testicular development, sperm maturation and testosterone synthesis...
- Characterization of a Mycobacterium tuberculosis ESX-3 conditional mutant: essentiality and rescue by iron and zincAgnese Serafini
Department of Histology, Microbiology, and Medical Biotechnologies, University of Padua, Via Gabelli 63, 35121 Padua, Italy
J Bacteriol 191:6340-4. 2009..bovis BCG attenuation. Another T7SS, ESX-3, has been previously shown to be transcriptionally controlled by the zinc uptake repressor (Zur) and by the iron-dependent transcriptional repressor (IdeR), suggesting that it might be ..
- Zinc salts inactivate clinical isolates of herpes simplex virus in vitroM Arens
The Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Clin Microbiol 38:1758-62. 2000Using a standard plaque assay and clinical isolates of herpes simplex virus (HSV), we have tested the ability of zinc salts to inactivate HSV...
- Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14K M Taylor
Tenovus Cancer Research Centre, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3XF, UK
FEBS Lett 579:427-32. 2005Here, we report the first investigation of a novel member of the LZT (LIV-1 subfamily of ZIP zinc Transporters) subfamily of zinc influx transporters...
- Zap1p, a metalloregulatory protein involved in zinc-responsive transcriptional regulation in Saccharomyces cerevisiaeH Zhao
Department of Biochemistry and Molecular Biology, University of Minnesota Duluth, 55812, USA
Mol Cell Biol 17:5044-52. 1997b>Zinc ion homeostasis in Saccharomyces cerevisiae is controlled primarily through the transcriptional regulation of zinc uptake systems in response to intracellular zinc levels...
- Nerve growth factor in different crystal forms displays structural flexibility and reveals zinc binding sitesD R Holland
Institute of Molecular Biology, Howard Hughes Medical Institute, Eugene, OR
J Mol Biol 239:385-400. 1994..1) with zinc acetate concentrations of 1 mM and 100 mM, respectively...
- Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 years in an urban, low-income population in Bangladesh: randomised controlled trialW Abdullah Brooks
The Centre for Health and Population Research, International Centre for Diarrhoea Disease Research, Mohakhali Dhaka 1000, Bangladesh
Lancet 366:999-1004. 2005..Most deaths occur during infancy and in developing countries. Daily regimens of zinc have been reported to prevent acute lower respiratory tract infection and diarrhoea, and to reduce child mortality...
- Visualization of transmitter release with zinc fluorescence detection at the mouse hippocampal mossy fibre synapseJing Qian
Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
J Physiol 566:747-58. 2005..Here we developed a technique to directly assess exocytosis by measuring vesicular zinc release with the zinc-sensitive dye FluoZin-3 at the hippocampal mossy fibre (MF) synapse...
- New insights into the role of zinc in the respiratory epitheliumA Q Truong-Tran
Department of Medicine, University of Adelaide, The Queen Elizabeth Hospital, Woodville, South Australia, Australia
Immunol Cell Biol 79:170-7. 2001Over the past 30 years, many researchers have demonstrated the critical role of zinc (Zn), a group IIb metal, in diverse physiological processes, such as growth and development, maintenance and priming of the immune system, and tissue ..
- Antidepressant-like properties of zinc in rodent forced swim testB Kroczka
Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
Brain Res Bull 55:297-300. 2001The effects of zinc, the N-methyl-D-aspartate glutamate receptor inhibitor, were studied in mice and rats using the forced swim test...
- The ZRT2 gene encodes the low affinity zinc transporter in Saccharomyces cerevisiaeH Zhao
Department of Biochemistry and Molecular Biology, School of Medicine, University of Minnesota, Duluth, Minnesota 55812, USA
J Biol Chem 271:23203-10. 1996b>Zinc accumulation in Saccharomyces cerevisiae occurs through either of two uptake systems. A high affinity system is active in zinc-limited cells, and the ZRT1 gene encodes the transporter protein of this system...
- An architectural framework that may lie at the core of the postsynaptic densityMarisa K Baron
Department of Chemistry and Biochemistry, Molecular Biology Institute, University of California, Los Angeles, 611 Charles E Young Drive East, Los Angeles, CA 90095 1570, USA
Science 311:531-5. 2006..Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex...
- Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapseYang Z Huang
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
Neuron 57:546-58. 2008..deletion of its prototypic neurotrophin ligands led us to hypothesize that a non-neurotrophin, the divalent cation zinc, can transactivate TrkB...
- MTP1-dependent Zn sequestration into shoot vacuoles suggests dual roles in Zn tolerance and accumulation in Zn-hyperaccumulating plantsJeffery L Gustin
Center for Plant Environmental Stress Physiology, Purdue University, West Lafayette, IN, USA
Plant J 57:1116-27. 2009..goesingense play a role in both Zn tolerance and enhanced Zn uptake and accumulation, via the activation of a systemic Zn deficiency response...
- Zinc pyrithione induces cellular stress signaling and apoptosis in Hep-2 cervical tumor cells: the role of mitochondria and lysosomesEmil Rudolf
Department of Medical Biology and Genetics, Faculty of Medicine in Hradec Kralove, Charles University in Prague, 500 01 Hradec Kralove I, Czech Republic
Biometals 23:339-54. 2010Increased intracellular free zinc concentrations are associated with activation of several stress signaling pathways, specific organelle injury and final cell death...
- Immune-enhancing role of vitamin C and zinc and effect on clinical conditionsEva S Wintergerst
Bayer Consumer Care Ltd, Basel, Switzerland
Ann Nutr Metab 50:85-94. 2006..Likewise, zinc undernutrition or deficiency was shown to impair cellular mediators of innate immunity such as phagocytosis, ..
- Design, synthesis and biological application of chemical probes for bio-imagingKazuya Kikuchi
Graduate School of Engineering, Osaka University, 2 1 Yamada oka, Suita City, Osaka 565 0871, Japan
Chem Soc Rev 39:2048-53. 2010..The MRI signal of the intrinsic (19)F is hardly detectable. A novel design strategy for (19)F MRI probes in detecting protease activity is described...
- ZINC COORDINATION AND REGULATION OF ZINC METALLOPROTEINSDAVID GIEDROC; Fiscal Year: 2003..continued support for ongoing studies of the structure, bioinorganic chemistry and allosteric regulation by zinc of selected zinc metalloregulatory transcription factors derived from mammalian and prokaryotic organisms which ..
- FUNCTIONAL ANALYSIS OF A LEAD/CADMIUM/ZINC ATPASEBharati Mitra; Fiscal Year: 2010..These pumps maintain homeostasis of essential trace metals like copper, zinc, cobalt and nickel, and mediate resistance to toxic metals such as lead, cadmium and silver...
- REGULATION OF CELLULAR ZINC HOMEOSTASISDavid Eide; Fiscal Year: 2009b>Zinc is an essential nutrient because of the important roles this metal plays as a catalytic and structural cofactor...
- Malaria in Pregnancy: Nutrition and Immunologic EffectsWafaie W Fawzi; Fiscal Year: 2010..Vitamin A and zinc deficiencies are specific factors which can modulate the clinical course of malaria and exacerbate associated ..
- Arsenic-enhanced skin carcinogenesis by UV radiationKe Liu; Fiscal Year: 2009..Proposed protein targets of arsenite include Poly (ADP-ribose) polymerase (PARP)- 1, a protein with two C3H1 zinc finger motifs in the DNA binding domain and one C4 zinc binding motif responsible for DNA-dependent catalytic ..
- Zinc inhibition of endotoxemia in alcoholic liver injuryZhanxiang Zhou; Fiscal Year: 2009b>Zinc inhibition of endotoxemia in alcoholic liver injury Abstract Alcoholic liver disease (ALD) is an important health problem, but an FDA-approved effective therapy is not available...
- FUNCTIONAL ANALYSIS OF A LEAD/CADMIUM/ZINC ATPASEBharati Mitra; Fiscal Year: 2007..These pumps maintain homeostasis of essential trace metals like copper, zinc, cobalt and nickel, and mediate resistance to toxic metals such as lead, cadmium and silver...
- Zinc inhibition of endotoxemia in alcoholic liver injuryZhanxiang Zhou; Fiscal Year: 2010b>Zinc inhibition of endotoxemia in alcoholic liver injury Abstract Alcoholic liver disease (ALD) is an important health problem, but an FDA-approved effective therapy is not available...
- Investigation of Zinc Neurochemistry by Optical Sensing and MRIStephen J Lippard; Fiscal Year: 2010..The long-term goal of this research is to devise molecular sensors for binding, visualizing, and quantifying mobile zinc in neurobiological systems...
- Genomic analysis of pediatric SIRS and septic shockHector Wong; Fiscal Year: 2009..The competitive revision seeks to develop a point-of-care platform for measuring serum zinc concentrations in children with septic shock, the "zinc chip...
- Effect of Zinc in Attaching and Effacing E. coli InfectionJOHN K contact CRANE; Fiscal Year: 2010b>Zinc has been shown to reduce the duration and severity of diarrheal diseases in studies of poor children on several continents...
- Structural Investigation of Allosteric Regulation in Bacterial Carbonic AnhydraseJEFF CRONK; Fiscal Year: 2007..and physiological importance, the interconversion of carbon dioxide and bicarbonate ion CO2 + H2O - All CAs are zinc-dependent enzymes and a well-established mechanistic paradigm requires the coordination of substrate to the ..
- Human Zinc Transporter Zip 13 and Cellular Zinc HomeostasisJoel Walker; Fiscal Year: 2007b>Zinc is an essential nutrient needed for many cellular processes, however, excess zinc leads to cell death...
- Towards tuberculosis control: pyrazinamide susceptibility and resistant mechanismPatricia Sheen; Fiscal Year: 2007..site, will revert its PZase activity, turning to a PZA-sensitive phenotype, under high concentrations of zinc ions, the probable cofactor...
- REGULATION OF CELLULAR ZINC HOMEOSTASISDavid J Eide; Fiscal Year: 2010b>Zinc is an essential nutrient because of the important roles this metal plays as a catalytic and structural cofactor...
- SYNTHETIC ANALOGUES OF ZINC ENZYMESGerard Parkin; Fiscal Year: 2003DESCRIPTION: (Adapted from applicant's abstract) Zinc is widely recognized as being essential to all forms of life, and in particular that of humans...
- THE ROLE OF ZINC FINGER GENES IN HEMATOPOIESISSinisa Dovat; Fiscal Year: 2003..Ikaros encodes a zinc finger protein whose expression is restricted to hematopoietic cells...
- DIETARY ZINC-ITS EFFECTS ON THE IMMUNE RESPONSEPamela Fraker; Fiscal Year: 2007The zinc deficient mouse (ZD) is a valuable model for elucidating the molecular and biochemical changes made by the immune system to provide a core of host defense in the face of suboptimal nutriture...