rhodium

Summary

Summary: Rhodium. A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh. (Dorland, 28th ed)

Top Publications

  1. ncbi Asymmetric catalytic hydrogenation. Design of new Ru catalysts and chiral ligands: from laboratory to industrial applications
    Jean Pierre Genet
    Ecole Nationale Superieure de Chimie de Paris, Laboratoire de Synthese Selective Organique et Produits Naturels, 11 Rue P et M Curie, 75231 Paris Cedex 05, France
    Acc Chem Res 36:908-18. 2003
  2. ncbi Cytogenetic and oxidative damage induced in human lymphocytes by platinum, rhodium and palladium compounds
    Lucia Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutagenesis 17:411-7. 2002
  3. pmc Rh(III)-catalyzed regioselective synthesis of pyridines from alkenes and α,β-unsaturated oxime esters
    Jamie M Neely
    Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States
    J Am Chem Soc 135:66-9. 2013
  4. ncbi Rhodium(III)-catalyzed heterocycle synthesis using an internal oxidant: improved reactivity and mechanistic studies
    Nicolas Guimond
    Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario K1N 6N5, Canada
    J Am Chem Soc 133:6449-57. 2011
  5. ncbi Isoquinoline synthesis via rhodium-catalyzed oxidative cross-coupling/cyclization of aryl aldimines and alkynes
    Nicolas Guimond
    Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Canada K1N 6N5
    J Am Chem Soc 131:12050-1. 2009
  6. ncbi Self-supported organometallic rhodium quinonoid nanocatalysts for stereoselective polymerization of phenylacetylene
    Kang Hyun Park
    Department of Chemistry, Sungkyunkwan University, Suwon 440 746, Korea
    J Am Chem Soc 128:8740-1. 2006
  7. ncbi Rhodium-catalyzed selective olefination of arene esters via C-H bond activation
    Sae Hume Park
    Department of Chemistry and Molecular Level Interface Research Center, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    Org Lett 13:2372-5. 2011
  8. pmc Biotinylated Rh(III) complexes in engineered streptavidin for accelerated asymmetric C-H activation
    Todd K Hyster
    Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA
    Science 338:500-3. 2012
  9. ncbi Aryl methyl sulfides as substrates for rhodium-catalyzed alkyne carbothiolation: arene functionalization with activating group recycling
    Joel F Hooper
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK
    J Am Chem Soc 134:2906-9. 2012
  10. ncbi Biomonitoring of tram drivers exposed to airborne platinum, rhodium and palladium
    Ivo Iavicoli
    Institute of Occupational Medicine, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy
    Int Arch Occup Environ Health 81:109-14. 2007

Detail Information

Publications293 found, 100 shown here

  1. ncbi Asymmetric catalytic hydrogenation. Design of new Ru catalysts and chiral ligands: from laboratory to industrial applications
    Jean Pierre Genet
    Ecole Nationale Superieure de Chimie de Paris, Laboratoire de Synthese Selective Organique et Produits Naturels, 11 Rue P et M Curie, 75231 Paris Cedex 05, France
    Acc Chem Res 36:908-18. 2003
    ..Applications of these ligands to rhodium- and ruthenium-mediated hydrogenation of ketones and olefins have been reported with high enantioselectivities...
  2. ncbi Cytogenetic and oxidative damage induced in human lymphocytes by platinum, rhodium and palladium compounds
    Lucia Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutagenesis 17:411-7. 2002
    This study of soluble compounds of platinum, palladium and rhodium investigated the genotoxic properties of (NH(4))(2)PtCl(4), PtCl(2), PtCl(4), (NH(4))(2)PdCl(4), PdCl(2) and RhCl(3) using the human lymphocyte micronucleus (MN) assay ..
  3. pmc Rh(III)-catalyzed regioselective synthesis of pyridines from alkenes and α,β-unsaturated oxime esters
    Jamie M Neely
    Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States
    J Am Chem Soc 135:66-9. 2013
    ..Mechanistic studies suggest that heterocycle formation proceeds via reversible C-H activation, alkene insertion, and a C-N bond formation/N-O bond cleavage process...
  4. ncbi Rhodium(III)-catalyzed heterocycle synthesis using an internal oxidant: improved reactivity and mechanistic studies
    Nicolas Guimond
    Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario K1N 6N5, Canada
    J Am Chem Soc 133:6449-57. 2011
    ..Pursuant to the rhodium(III)-catalyzed redox-neutral isoquinolone synthesis that we recently reported, we present in this article the ..
  5. ncbi Isoquinoline synthesis via rhodium-catalyzed oxidative cross-coupling/cyclization of aryl aldimines and alkynes
    Nicolas Guimond
    Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Canada K1N 6N5
    J Am Chem Soc 131:12050-1. 2009
    A general rhodium-catalyzed oxidative coupling reaction between internal alkynes and aryl aldimines is described. This process affords 3,4-disubstituted isoquinolines in good yield and high regioselectivity...
  6. ncbi Self-supported organometallic rhodium quinonoid nanocatalysts for stereoselective polymerization of phenylacetylene
    Kang Hyun Park
    Department of Chemistry, Sungkyunkwan University, Suwon 440 746, Korea
    J Am Chem Soc 128:8740-1. 2006
    ..self-supported organometallic nanocatalysts (ONs) were synthesized by treatment of the eta6-pi-hydroquinone rhodium complex [(1,4-hydroquinone)Rh(COD)]+ with Al(Oi-Pr)3...
  7. ncbi Rhodium-catalyzed selective olefination of arene esters via C-H bond activation
    Sae Hume Park
    Department of Chemistry and Molecular Level Interface Research Center, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    Org Lett 13:2372-5. 2011
    ..The reaction is highly regioselective with a range of benzoates and benzaldehydes enabling the efficient olefination with acrylates, acrylic acid, and styrenes...
  8. pmc Biotinylated Rh(III) complexes in engineered streptavidin for accelerated asymmetric C-H activation
    Todd K Hyster
    Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA
    Science 338:500-3. 2012
    ..a glutamic acid or aspartic acid residue engineered into streptavidin acts in concert with a docked biotinylated rhodium(III) complex to enable catalytic asymmetric carbon-hydrogen (C-H) activation...
  9. ncbi Aryl methyl sulfides as substrates for rhodium-catalyzed alkyne carbothiolation: arene functionalization with activating group recycling
    Joel F Hooper
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK
    J Am Chem Soc 134:2906-9. 2012
    ..The utility of the alkenyl sulfide products is also demonstrated in simple carbo- and heterocycle-forming processes. We also provide mechanistic evidence for the course of this new process...
  10. ncbi Biomonitoring of tram drivers exposed to airborne platinum, rhodium and palladium
    Ivo Iavicoli
    Institute of Occupational Medicine, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy
    Int Arch Occup Environ Health 81:109-14. 2007
    ..The aim of this study was to evaluate urinary levels of Pt, Rh and Pd in occupationally exposed subjects...
  11. ncbi Changes in palladium, platinum, and rhodium concentrations, and their spatial distribution in soils along a major highway in Germany from 1994 to 2004
    Fathi Zereini
    Institute of Atmospheric and Environmental Sciences, Department of Analytical Environmental Chemistry, J W Goethe University Frankfurt, Georg Voigt Strasse 16, D 60054 Frankfurt am Main, Germany
    Environ Sci Technol 41:451-6. 2007
    ..Kreuz to Darmstäder Kreuz from July to September, 2004 and analyzed for palladium (Pd), platinum (Pt), and rhodium (Rh)...
  12. ncbi Asymmetric rhodium-catalyzed hydrogenation meets gold-catalyzed cyclization: Enantioselective synthesis of 8-hydroxytetrahydroisoquinolines
    A Stephen K Hashmi
    Institut fur Organische Chemie, Universitat Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart, Germany
    Chemistry 12:5376-82. 2006
    Different furyl-substituted (Z)-dehydroamino acid derivatives were hydrogenated with the rhodium/Mandyphos(OMe)-system to give enantiomeric excesses between 80 and 98 %...
  13. ncbi A rhodium(I)-catalyzed demethylation-cyclization of o-anisole-substituted ynamides in the synthesis of chiral 2-amido benzofurans
    Jossian Oppenheimer
    Division of Pharmaceutical Sciencies and Department of Chemistry, University of Wisconsin Madison, Rennebohm Hall, 777 Highland Avenue, Madison, Wisconsin 53705 2222, USA
    Org Lett 9:2361-4. 2007
    ..A Rh(I)-catalyzed demethylation-cyclization sequence for a direct transformation of o-anisole-substituted ynamides to benzofurans is described here. The Ag salt functions synergistically with Rh(I) for the key demethylation step...
  14. ncbi Rhodium(III) and iridium(III) complexes with 1,2-naphthoquinone-1-oximate as a bidentate ligand: synthesis, structure, and biological activity
    Stefan Wirth
    Department of Chemistry and Biochemistry, Ludwig Maximilian University Munich, Butenandtstr 5 13 house D, 81377, Munich, Germany
    J Biol Inorg Chem 15:429-40. 2010
    The synthesis and characterization of three novel iridium(III) complexes and one rhodium(III) complex with 1-nitroso-2-naphthol (3) chelating as a 1,2-naphthoquinone-1-oximato ligand are described...
  15. ncbi Different effects of platinum, palladium, and rhodium salts on lymphocyte proliferation and cytokine release
    Paolo Boscolo
    Department of Medicine and Science of Ageing, G D Annunzio University of Chieti and Pescara, Italy
    Ann Clin Lab Sci 34:299-306. 2004
    ....
  16. ncbi Surface-enhanced Raman scattering in the ultraviolet spectral region: UV-SERS on rhodium and ruthenium electrodes
    Bin Ren
    State Key Laboratory for Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen 361005, China
    J Am Chem Soc 125:9598-9. 2003
    ..Adsorbed pyridine and SCN- on rough rhodium (Rh) and ruthenium (Ru) electrodes, respectively, have been studied using 325 nm laser excitation...
  17. pmc DNA base mismatch detection with bulky rhodium intercalators: synthesis and applications
    Brian M Zeglis
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Nat Protoc 2:357-71. 2007
    ..The synthesis of the metallointercalators requires approximately 5-7 d. The mismatch- and SNP-detection experiments each require approximately 3 d...
  18. pmc Cell-selective biological activity of rhodium metalloinsertors correlates with subcellular localization
    Alexis C Komor
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    J Am Chem Soc 134:19223-33. 2012
    ..b>Rhodium metalloinsertors have been found to bind DNA mismatches with high affinity and specificity in vitro, and also ..
  19. ncbi Synthesis and reactivity of a transient, terminal nitrido complex of rhodium
    Markus G Scheibel
    Institut fur Anorganische Chemie, Georg August Universitat, Tammannstraße 4, 37077 Gottingen, Germany
    J Am Chem Soc 135:17719-22. 2013
    Irradiation of rhodium(II) azido complex [Rh(N3){N(CHCHPtBu2)2}] allowed for the spectroscopic characterization of the first reported rhodium complex with a terminal nitrido ligand...
  20. ncbi Cellular selectivity and biological impact of cytotoxic rhodium(III) and iridium(III) complexes containing methyl-substituted phenanthroline ligands
    Yvonne Geldmacher
    Fakultät für Chemie und Biochemie, Ruhr Universitat Bochum, 44780 Bochum, Germany
    ChemMedChem 6:429-39. 2011
    ..A series of similar rhodium(III) complexes were studied for comparison purposes...
  21. ncbi Methoxy-directed aryl-to-aryl 1,3-rhodium migration
    Jing Zhang
    Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58102, United States
    J Am Chem Soc 135:17270-3. 2013
    ..of a Rh(I) 2,6-dimethoxybenzoate complex that underwent stoichiometric rearrangement via a highly unusual 1,3-rhodium migration...
  22. pmc Rhodium(I)-catalyzed cycloisomerizations of bicyclobutanes
    Maciej A A Walczak
    Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, USA
    J Am Chem Soc 130:6924-5. 2008
    The selection of rhodium precatalyst and phosphine ligand determines the course of the cycloisomerization of N-allylated bicyclo[1.1.0]butylalkylamines...
  23. pmc Nickel, palladium and rhodium induced IFN-gamma and IL-10 production as assessed by in vitro ELISpot-analysis in contact dermatitis patients
    Valentina Bordignon
    Laboratory of Clinical Pathology, Department of Allergology and Laboratory of Skin Physiopathology, Institute San Gallicano, IRCCS, IFO, Rome, Italy
    BMC Immunol 9:19. 2008
    ..study was undertaken with the aim to evaluate the potential for an allergic response to nickel, palladium and rhodium on the basis of antigen-specific induction of inflammatory/regulatory cytokines, and to characterize, according ..
  24. ncbi Domino rhodium/palladium-catalyzed dehydrogenation reactions of alcohols to acids by hydrogen transfer to inactivated alkenes
    Monica Trincado
    Department of Chemistry and Applied Biosciences, ETH Honggerberg, 8093 Zurich, Switzerland
    Chemistry 16:2751-7. 2010
    ..The dehydrogenation of benzyl alcohol by the rhodium amide, [Rh]N, follows the well established mechanism of metal-ligand bifunctional catalysis...
  25. pmc DNA mismatch-specific targeting and hypersensitivity of mismatch-repair-deficient cells to bulky rhodium(III) intercalators
    Jonathan R Hart
    Division of Chemistry and Chemical Engineering, California Institute of Technology Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 103:15359-63. 2006
    ..Bulky rhodium intercalators target DNA base mismatches with high specificity...
  26. ncbi Synthesis, biochemical evaluation and molecular modeling studies of novel rhodium complexes with nanomolar activity against Platelet Activating Factor
    Alexandros B Tsoupras
    Laboratory of Biochemistry, Faculty of Chemistry, National and Kapodistrian University of Athens, Athens 15771, Greece
    J Inorg Biochem 120:63-73. 2013
    ..L(1)=2,2'-pyridylquinoxaline (1-Cl), [Rh(L1)(cod)](NO3) (1-NO(3)) and a series of novel octahedral rhodium(III) complexes of the general formulae mer-[Rh(L(1))Cl(3)(MeOH)] (2) and cis-[Rh(L(2))(2)Cl(2)]Cl (L(2)=4 carboxy ..
  27. ncbi Novel C,N-chelate rhodium(III) and iridium(III) antitumor complexes incorporating a lipophilic steroidal conjugate and their interaction with DNA
    Jose Ruiz
    Departamento de Química Inorgánica and Regional Campus of International Excellence Campus Mare Nostrum, Universidad de Murcia and Instituto Murciano de Investigación Biosanitaria, 30071 Murcia, Spain
    Dalton Trans 41:12847-56. 2012
    ..Complexes 1 and 2 are also cathepsin B inhibitors, an enzyme implicated in a number of cancer related events...
  28. ncbi Highly enantioselective and efficient synthesis of flavanones including pinostrobin through the rhodium-catalyzed asymmetric 1,4-addition
    Toshinobu Korenaga
    Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University, 3 1 1 Tsushima naka, Okayama 700 8530, Japan
    Org Lett 13:2022-5. 2011
    ..In this reaction, the 1,2-addition to (S)-1 frequently occurred to yield (2S,4R)-2,4-diaryl-4-chromanol as a byproduct, which could be reduced by changing the reaction solvent to CH(2)Cl(2) to deactivate the Rh catalyst (3% required)...
  29. pmc Expedient synthesis of N-acyl anthranilamides and β-enamine amides by the Rh(III)-catalyzed amidation of aryl and vinyl C-H bonds with isocyanates
    Kevin D Hesp
    Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA
    J Am Chem Soc 133:11430-3. 2011
    ..This method provides direct and efficient syntheses of N-acyl anthranilamides, enamine amides, and pyrimidin-4-one heterocycles...
  30. ncbi Covalent binding and interstrand cross-linking of duplex DNA by dirhodium(II,II) carboxylate compounds
    Shari U Dunham
    Department of Chemistry, Colby College, Waterville, Maine 04901, USA
    Biochemistry 44:996-1003. 2005
    ..Since all three dirhodium compounds form covalent Rh-DNA adducts, including interstrand cross-links, it is important that DNA be considered a potential target for biological activity of these dirhodium carboxylate compounds...
  31. ncbi Cell-selective, apoptosis-inducing rhodium(III) crown thiaether complexes
    Ruth Bieda
    Lehrstuhl fur Analytische Chemie, Ruhr Universitat Bochum, 44780 Bochum, Germany
    ChemMedChem 5:1123-33. 2010
    Half-sandwich rhodium(III) polypyridyl (pp) complexes with the metal atom capped by the facial crown thiaether 1,4,7-trithiacyclononane [9]aneS(3) represent a promising class of apoptosis-inducing potent cytostatic agents...
  32. ncbi Rhodium N-heterocyclic carbene-catalyzed [4 + 2] and [5 + 2] cycloaddition reactions
    Sang Ick Lee
    Intelligent Textile System Research Center, Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    J Org Chem 71:91-6. 2006
    reactions: see text] A rhodium complex of N-heterocyclic carbene (NHC) has been developed for intra- and intermolecular [4 + 2] and intramolecular [5 + 2] cycloaddition reactions...
  33. ncbi Conformational studies on chiral rhodium complexes by ECD and VCD spectroscopy
    Gábor Szilvágyi
    Laboratory for Chiroptical Structure Analysis, Institute of Chemistry, Eotvos Lorand University, Budapest, Hungary
    Chirality 23:294-9. 2011
    ..The combination of the VCD and ECD spectroscopic methods led us to the structural characterization of the complexes...
  34. ncbi Binding of DNA purine sites to dirhodium compounds probed by mass spectrometry
    Helen T Chifotides
    Chemistry Department and Laboratory for Biological Mass Spectrometry, Texas A and M University, College Station, Texas 77843, USA
    Inorg Chem 43:6177-87. 2004
    ..Ultimately, both MALDI and ESI MS proved to be complementary, valuable tools for probing the identity and stability of dinuclear metal-DNA adducts...
  35. pmc Rhodium-catalyzed synthesis of branched amines by direct addition of benzamides to imines
    Kevin D Hesp
    Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States
    Org Lett 14:2304-7. 2012
    b>Rhodium-catalyzed addition of benzamide C-H bonds to a range of aromatic N-sulfonyl aldimines has been developed and proceeds with high functional group compatibility...
  36. ncbi Antileukemic activity and cellular effects of rhodium(III) crown thiaether complexes
    Ruth Bieda
    Lehrstuhl fur Analytische Chemie, Ruhr Universitat Bochum, 44780 Bochum, Germany
    Biometals 24:645-61. 2011
    The cytostatic properties of novel rhodium(III) thiacrown ether complexes [RhCl(LL)([9]aneS(3))](n+) with either aromatic κ(2)N ligands (n = 2) or anionic chelate ligands (n = 1) have been investigated for the human cancer cell lines HT-..
  37. ncbi Tandem Rh(III)-catalyzed oxidative acylation of secondary benzamides with aldehydes and intramolecular cyclization: the direct synthesis of 3-hydroxyisoindolin-1-ones
    Satyasheel Sharma
    Department of Chemistry, University of Ulsan, Ulsan, 680 749, Republic of Korea
    Org Lett 14:906-9. 2012
    The rhodium-catalyzed oxidative acylation between secondary benzamides and aryl aldehydes via sp(2) C-H bond activation followed by an intramolecular cyclization is described...
  38. pmc Mechanism of the rhodium(III)-catalyzed arylation of imines via C-H bond functionalization: inhibition by substrate
    Michael E Tauchert
    Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA
    J Am Chem Soc 134:1482-5. 2012
    ..The reaction was found to be first order in the catalyst resting state and inverse first order in the C-H activation substrate...
  39. ncbi N-Directing group assisted rhodium-catalyzed aryl C-H addition to aryl aldehydes
    Yang Li
    Beijing National Laboratory of Molecular Sciences BNLMS, College of Chemistry, Peking University, Beijing 100871, China
    Org Lett 14:636-9. 2012
    ..The method is highly atom-, step-, and redox-economic. The procedure is robust, reliable, and compatible with water and air...
  40. doi Mild and efficient H/D exchange of alkanes based on C-H activation catalyzed by rhodium on charcoal
    Tomohiro Maegawa
    Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5 6 1 Mitahora higashi Gifu 502 8585, Japan
    Angew Chem Int Ed Engl 47:5394-7. 2008
  41. ncbi Rhodium(III)-catalyzed arene and alkene C-H bond functionalization leading to indoles and pyrroles
    David R Stuart
    Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Canada K1N 6N5
    J Am Chem Soc 132:18326-39. 2010
    Recently, the rhodium(III)-complex [Cp*RhCl(2)](2) 1 has provided exciting opportunities for the efficient synthesis of aromatic heterocycles based on a rhodium-catalyzed C-H bond functionalization event...
  42. ncbi Rhodium catalyzed [4 + 2 + 2] cycloaddition and alkyne insertion: a new route to eight-membered rings
    Scott R Gilbertson
    Department of Chemistry, Washington University, Saint Louis, Missouri 63130, USA
    J Am Chem Soc 124:8784-5. 2002
    A novel variation of the rhodium catalyzed [4 + 2] reaction is reported. A catalyst system that forms an eight-membered ring product from the incorporation of an alkyne into a dienyne is discussed...
  43. ncbi Rhodium-catalyzed oxidative ortho-acylation of benzamides with aldehydes: direct functionalization of the sp2 C-H bond
    Jihye Park
    Department of Chemistry, University of Ulsan, Ulsan, 680 749, Republic of Korea
    Org Lett 13:4390-3. 2011
    A rhodium-catalyzed oxidative acylation of benzamides with aryl aldehydes via direct sp(2) C-H bond cleavage is described...
  44. pmc Rhodium(III)-catalyzed arylation of Boc-imines via C-H bond functionalization
    Andy S Tsai
    Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States
    J Am Chem Soc 133:1248-50. 2011
    The first rhodium-catalyzed arylation of imines proceeding via C-H bond functionalization is reported. Use of a non-coordinating halide abstractor is important to obtain reactivity...
  45. pmc Selective cytotoxicity of rhodium metalloinsertors in mismatch repair-deficient cells
    Russell J Ernst
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States
    Biochemistry 50:10919-28. 2011
    ..b>Rhodium metalloinsertors bind to DNA mismatches with high affinity and specificity and represent a promising strategy to ..
  46. ncbi Rhodium-catalyzed synthesis of eight-membered rings
    Brenton DeBoef
    Department of Chemistry, Washington University, One Brookings Drive, Saint Louis, Missouri 63130 4899, USA
    J Org Chem 72:799-804. 2007
    Experiments to develop a rhodium catalyst for the [4 + 2 + 2] cycloisomerization of dienynes with a second alkyne are described. The generality of the reaction is probed in terms of dienyne structure and alkyne structure...
  47. ncbi Occupational immediate-type asthma and rhinitis due to rhodium salts
    Rolf Merget
    Research Institute of Occupational Medicine, German Social Accident Insurance BGFA, Ruhr University, Burkle de la Camp Platz 1, Bochum, Germany
    Am J Ind Med 53:42-6. 2010
    Whereas platinum salts are well known occupational allergens, rhodium salts have not been identified as inhalative sensitizing substances.
  48. pmc DNA mismatch binding and antiproliferative activity of rhodium metalloinsertors
    Russell J Ernst
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    J Am Chem Soc 131:2359-66. 2009
    Deficiencies in mismatch repair (MMR) are associated with carcinogenesis. Rhodium metalloinsertors bind to DNA base mismatches with high specificity and inhibit cellular proliferation preferentially in MMR-deficient cells versus MMR-..
  49. pmc A bulky rhodium complex bound to an adenosine-adenosine DNA mismatch: general architecture of the metalloinsertion binding mode
    Brian M Zeglis
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Biochemistry 48:4247-53. 2009
    ..In both structures, the bulky rhodium complex inserts into the two mismatched sites from the minor groove side, ejecting the mismatched bases into the ..
  50. ncbi Rhodium(III)-catalyzed isoquinolone synthesis: the N-O bond as a handle for C-N bond formation and catalyst turnover
    Nicolas Guimond
    Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario K1N 6N5, Canada
    J Am Chem Soc 132:6908-9. 2010
    ..Mechanistic studies point out the important involvement of a N-O bond as a tool for C-N bond formation and catalyst turnover...
  51. ncbi Application of chiral mixed phosphorus/sulfur ligands to enantioselective rhodium-catalyzed dehydroamino acid hydrogenation and ketone hydrosilylation processes
    David A Evans
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Am Chem Soc 125:3534-43. 2003
    ....
  52. pmc Free Rhodium (II) citrate and rhodium (II) citrate magnetic carriers as potential strategies for breast cancer therapy
    Marcella L B Carneiro
    Instituto de Ciencias Biologicas, Universidade de Brasilia, Brazil, 70 919 970
    J Nanobiotechnology 9:11. 2011
    b>Rhodium (II) citrate (Rh(2)(H(2)cit)(4)) has significant antitumor, cytotoxic, and cytostatic activity on Ehrlich ascite tumor...
  53. ncbi Direct electron transfer between cytochrome P450scc and gold nanoparticles on screen-printed rhodium-graphite electrodes
    Victoria V Shumyantseva
    Institute of Biomedical Chemistry, Pogodinskaya st 10, Moscow 119121, Russia
    Biosens Bioelectron 21:217-22. 2005
    ..an investigation of electron transfer between cytochrome P450scc (CYP11A1) and gold nanoparticles immobilised on rhodium-graphite electrodes...
  54. pmc Insights into finding a mismatch through the structure of a mispaired DNA bound by a rhodium intercalator
    Valérie C Pierre
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 104:429-34. 2007
    We report the 1.1-A resolution crystal structure of a bulky rhodium complex bound to two different DNA sites, mismatched and matched in the oligonucleotide 5'-(dCGGAAATTCCCG)2-3'...
  55. ncbi Isotope effects and the nature of selectivity in rhodium-catalyzed cyclopropanations
    Daniel T Nowlan
    Department of Chemistry, Texas A and M University, P O Box 30012, College Station, Texas 77842, USA
    J Am Chem Soc 125:15902-11. 2003
    ..functional theory calculations (B3LYP) predict a reaction pathway involving complexation of the diazoesters to rhodium, loss of N(2) to afford a rhodium carbenoid, and an asynchronous but concerted cyclopropanation transition state...
  56. ncbi Encapsulation and release of rhodium(II) citrate and its association complex with hydroxypropyl-beta-cyclodextrin from biodegradable polymer microspheres
    R D Sinisterra
    Chemical Engineering Department, Massachusetts Institute of Technology, 45 Carleton Street, Bldg E25, Rm 342, Cambridge, Massachusetts 02139, USA
    J Pharm Sci 88:574-6. 1999
    b>Rhodium(II) carboxylates and their derivatives constitute a promising class of second-generation transition metal compounds with anticancer properties...
  57. ncbi Rhodium and its compounds as potential agents in cancer treatment
    N Katsaros
    National Centre of Scientific Research Demokritos, Institute of Physical Chemistry, Agia Paraskevi Attikis, Greece
    Crit Rev Oncol Hematol 42:297-308. 2002
    ..b>Rhodium belongs to the same group as platinum and ruthenium...
  58. ncbi Synthesis, biological activity, and structure-activity relationships for potent cytotoxic rhodium(III) polypyridyl complexes
    Melanie Harlos
    Lehrstuhl fur Analytische Chemie, Ruhr Universitat Bochum, D 44780 Bochum, Germany
    J Med Chem 51:3924-33. 2008
    ..Treatment of HT-29 and MCF-7 cells with 3a leads to significant decreases in cellular oxygen consumption and the rate of extracellular acidification...
  59. ncbi Controlled release of rhodium (II) carboxylates and their association complexes with cyclodextrins from hydroxyapatite matrix
    A E Burgos
    Departamento de Química ICEx, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Biomaterials 23:2519-26. 2002
    Preparation and characterization of a controlled release system of rhodium (II) citrate, acetate. propionate, butyrate and their inclusion or association compounds with cyclodextrin (CD) are described...
  60. pmc A rhodium(III) complex for high-affinity DNA base-pair mismatch recognition
    Henrik Junicke
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 100:3737-42. 2003
    A rhodium(III) complex, rac-[Rh(bpy)(2)phzi](3+) (bpy, 2,2'-bipyridine; phzi, benzo[a]phenazine-5,6-quinone diimine) has been designed as a sterically demanding intercalator targeted to destabilized mismatched sites in double-helical DNA...
  61. ncbi Comparison of the anti-neoplastic effects of dirhodium(II) tetrapropionate and its adducts with nicotinate and isonicotinate anions in mice bearing Ehrlich tumors
    Aparecido Ribeiro de Souza
    Instituto de Quimica, Universidade Federal de Goias, Campus Samambaia, CP 131, 74001 970 Goiania, GO, Brazil
    Eur J Med Chem 41:1214-6. 2006
    b>Rhodium(II) propionate, [Rh2(prop)4], and its adduct with nicotinate (nic-) and isonicotinate (isonic-) anions, [Rh2(prop)4(nic)2](2-) and [Rh2(prop)4(isonic)2](2-), respectively, were prepared for study...
  62. ncbi Dirhodium(II,II) complexes: molecular characteristics that affect in vitro activity
    Alfredo M Angeles-Boza
    Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, USA
    J Med Chem 49:6841-7. 2006
    ..The toxicities of complexes 1-8 are not related to their charge or the ease by which they transverse the cellular membrane but to the lability of the ligands on the dirhodium core...
  63. ncbi Domino reactions of rhodium(II) carbenoids for alkaloid synthesis
    Albert Padwa
    Department of Chemistry, Atlanta, GA, USA
    Chem Soc Rev 38:3072-81. 2009
    In this tutorial review, the rhodium(II)-catalyzed domino reactions of alpha-diazo carbonyl compounds are summarized...
  64. ncbi Artificial metalloenzymes: (strept)avidin as host for enantioselective hydrogenation by achiral biotinylated rhodium-diphosphine complexes
    Myriem Skander
    Institute of Chemistry, University of Neuchatel, Avenue Bellevaux 51, CP2, CH 2007 Neuchatel, Switzerland
    J Am Chem Soc 126:14411-8. 2004
    We report on the generation of artificial metalloenzymes based on the noncovalent incorporation of biotinylated rhodium-diphosphine complexes in (strept)avidin as host proteins...
  65. ncbi Use of viscogens, dNTPalphaS, and rhodium(III) as probes in stopped-flow experiments to obtain new evidence for the mechanism of catalysis by DNA polymerase beta
    Marina Bakhtina
    Department of Chemistry and Biochemistry and Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 44:5177-87. 2005
    ..The methodologies can be used to examine other DNA polymerases to answer whether the properties of Pol beta are exceptional or general...
  66. ncbi A circular dichroism and fluorescence quenching study of the interactions between rhodium(II) complexes and human serum albumin
    B P Espósito
    Departamento de Quimica Fundamental, Universidade de Sao Paulo, Brazil
    J Inorg Biochem 75:55-61. 1999
    Various divalent rhodium complexes Rh2(L)4 (L = acetate, propionate, butyrate, trifluoroacetate and trifluoroacetamidate) have been found to bind to non-defatted human serum albumin (HSA) at molar ratios about 8:1...
  67. ncbi A mismatch-selective bifunctional rhodium-Oregon Green conjugate: a fluorescent probe for mismatched DNA
    Brian M Zeglis
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    J Am Chem Soc 128:5654-5. 2006
    ....
  68. ncbi Rhodium catalysed conjugate addition of a chiral alkenyltrifluoroborate salt: the enantioselective synthesis of hermitamides A and B
    Christopher G Frost
    Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK
    Org Biomol Chem 6:4340-7. 2008
    The concise enantioselective synthesis of hermitamides A and B is presented utilising a rhodium catalysed conjugate addition reaction to introduce the side chain and chiral information in a single step via an alkenyltrifluoroborate salt.
  69. ncbi Synthesis of 1,2-diheteroatom-substituted alkenes via rhodium-catalyzed intramolecular hydrogen transfer
    M Mar Diaz-Requejo
    Department of Chemistry, University of North Carolina at Chapel Hill, CB 3290 Venable Hall, Chapel Hill, North Carolina 27599 3290, USA
    J Am Chem Soc 125:2038-9. 2003
    ..We describe here a simple catalytic procedure based on rhodium C-H bond activation for the synthesis of diheteroatom alkenes of the type R(3)SiOCH=CHG (G = -OR, -NRR').
  70. ncbi Selective tryptophan modification with rhodium carbenoids in aqueous solution
    John M Antos
    Department of Chemistry, University of California, Berkeley, CA 94720 1460, USA
    J Am Chem Soc 126:10256-7. 2004
    ..It was also demonstrated that myoblobin concentrations as low as 10 muM still led to appreciable levels of modification. Reconstitution experiments confirmed that myoglobin retained its ability to bind heme following modification...
  71. ncbi Molybdenum, rhodium, and tungsten anode spectral models using interpolating polynomials with application to mammography
    J M Boone
    Department of Radiology, University of California, Davis, UC Davis Medical Center, Sacramento 95817, USA
    Med Phys 24:1863-74. 1997
    ..Using x-ray spectra measured for molybdenum, rhodium, and tungsten anode x-ray tubes at 13 different kV's (18, 20, 22, .....
  72. ncbi Synthesis of phthalocyanine stabilized rhodium nanoparticles and their application in biosensing of cytochrome c
    K S Lokesh
    Govt Science College, Hassan, Karnataka, India
    Bioelectrochemistry 75:104-9. 2009
    A single step synthesis route is described for the preparation of rhodium nanoparticles using a cobalt aminophthalocyanine macrocyclic complex as a stabilizer...
  73. pmc Insertion of a bulky rhodium complex into a DNA cytosine-cytosine mismatch: an NMR solution study
    Christine Cordier
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    J Am Chem Soc 129:12287-95. 2007
    ..These results corroborate those obtained crystallographically and, importantly, provide structural evidence for this specific insertion mode in solution...
  74. ncbi Rhodium-catalyzed ring-opening reactions of N-boc-azabenzonorbornadienes with amine nucleophiles
    Yong hwan Cho
    Davenport Laboratories, Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario, Canada M5H 3H6
    J Am Chem Soc 128:6837-46. 2006
    In the presence of a rhodium catalyst (5 mol %) generated in situ from [Rh(cod)Cl](2) and (S,S')-(R,R')-C(2)-ferriphos (4a), the asymmetric ring-opening reaction of azabenzonorbornadienes (1a-m) with various aliphatic and aromatic amines ..
  75. ncbi N-tosyloxycarbamates as a source of metal nitrenes: rhodium-catalyzed C-H insertion and aziridination reactions
    Hélène Lebel
    Departement de Chimie, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3J7
    J Am Chem Soc 127:14198-9. 2005
    The rhodium-catalyzed decomposition of N-tosyloxycarbamates to generate metal nitrenes which undergo intramolecular C-H insertion or aziridination reaction is described...
  76. ncbi Enantioselective rhodium-catalyzed [2+2+2] cycloaddition of alkenyl isocyanates and terminal alkynes: application to the total synthesis of (+)-lasubine II
    Robert T Yu
    Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA
    J Am Chem Soc 128:12370-1. 2006
    The use of TADDOL-based phosphoramidite ligands on rhodium allows for the incorporation of terminal alkynes in the [2+2+2] cycloaddition with alkenyl isocyanates...
  77. ncbi Radiosensitization of CHO cells by two novel rhodium complexes under oxic and hypoxic conditions
    Nadia Falzone
    Department of Biomedical Sciences, Tswhane University of Technology, Pretoria, South Africa
    Anticancer Res 26:147-52. 2006
    ..Tumour hypoxia severely limits the success of radiotherapy. Radiosensitization of hypoxic tumour cells by drugs is thus an important clinical issue...
  78. pmc A chiral rhodium carboxamidate catalyst for enantioselective C-H amination
    David N Zalatan
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
    J Am Chem Soc 130:9220-1. 2008
    ..In addition, Rh2(S-nap)4 is found to promote chemoselective allylic C-H oxidation of unsaturated sulfamates, a property not observed with other dirhodium complexes tested to date...
  79. ncbi Cytotoxicity and cell death pathways invoked by two new rhodium-ferrocene complexes in benign and malignant prostatic cell lines
    Brandon Weber
    Department of Radiation Oncology, University of Stellenbosch, Tygerberg, SA
    Anticancer Res 24:763-70. 2004
    ..This investigation explores the onset of apoptosis and abnormal morphology in response to 3 drugs i.e. Cisplatin, a novel Ferrocene (fctfa) and a novel Rhodium-Ferrocene [Rh(fctfa)(cod)] complex.
  80. ncbi Rh-catalyzed asymmetric hydrogenation of gamma-phthalimido-substituted alpha,beta-unsaturated carboxylic acid esters: an efficient enantioselective synthesis of beta-aryl-gamma-amino acids
    Jun Deng
    Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
    Org Lett 9:4825-8. 2007
    ..The method has been applied successfully to the synthesis of several chiral pharmaceuticals including (R)-baclofen and (R)-rolipram with high enantioselectivities...
  81. ncbi Rhodium-complex-catalyzed asymmetric hydrogenation: transformation of precatalysts into active species
    Angelika Preetz
    Leibniz Institut fur Katalyse e V an der Universitat Rostock, Albert Einstein Strasse 29a, Germany
    Chemistry 14:1445-51. 2008
    The use of diolefin-containing rhodium precatalysts leads to induction periods in asymmetric hydrogenation of prochiral olefins. Consequently, the reaction rate increases in the beginning...
  82. ncbi Highly Enantio- and s-trans C=C bond selective catalytic hydrogenation of cyclic enones: alternative synthesis of (-)-menthol
    Takashi Ohshima
    Department of Chemistry, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560 8531, Japan
    Chemistry 14:2060-6. 2008
    ..Moreover, we found that the complete s-trans and s-cis C=C bond selective reactions were also realized by the proper choice of both the chiral ligands and halides...
  83. ncbi Rh III- and Ir III-catalyzed asymmetric transfer hydrogenation of ketones in water
    Xiaofeng Wu
    Liverpool Centre for Materials and Catalysis, Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, UK
    Chemistry 14:2209-22. 2008
    ..The aqueous phase reduction is simple, efficient and environmentally benign, thus presenting a viable alternative for asymmetric reduction...
  84. ncbi Synthesis of new chiral monodentate phosphite ligands and their use in catalytic asymmetric hydrogenation
    Zihao Hua
    Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794 3400, USA
    Org Lett 5:3831-4. 2003
    ..The new chiral ligand system is suitable to create libraries and possesses fine-tuning capability...
  85. ncbi Asymmetric hydrogenation of unsaturated ureas with the BIPI ligands
    Carl A Busacca
    Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc, 900 Ridgebury Road, Ridgefield, Connecticut 06877, USA
    Org Lett 10:341-4. 2008
    ..Optimization of the P-N ligand structure has led to the development of chiral rhodium catalysts capable of producing the targets with >99% ee...
  86. ncbi Exploiting self-assembly for ligand-scaffold optimization: substrate-tailored ligands for efficient catalytic asymmetric hydroboration
    Shin A Moteki
    Department of Chemistry, University of Nebraska Lincoln, Lincoln, NE 68588 0304, USA
    Angew Chem Int Ed Engl 47:894-7. 2008
  87. pmc Rhodium(I)-catalyzed allenic carbocyclization reaction affording delta- and epsilon-lactams
    Kay M Brummond
    Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Org Lett 9:347-9. 2007
    This letter extends the scope of the rhodium(I)-catalyzed allenic Alder-ene carbocyclization reaction to the preparation of delta- and epsilon-lactams from amides...
  88. ncbi Asymmetric induction in hydrogen-mediated reductive aldol additions to alpha-amino aldehydes catalyzed by rhodium: selective formation of syn-stereotriads directed by intramolecular hydrogen-bonding
    Cheol Kyu Jung
    Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, TX 78712, USA
    J Am Chem Soc 128:17051-6. 2006
    b>Rhodium-catalyzed hydrogenation of methyl vinyl ketone and ethyl vinyl ketone in the presence of N-Boc-alpha-aminoaldehydes 3a-8a at ambient temperature and pressure results in reductive C-C coupling to furnish aldol adducts 3b-8b and 3c-..
  89. ncbi The complete characterization of a rhodium Lewis acid-dipolarophile complex as an intermediate for the enantioselective catalytic 1,3-dipolar cycloaddition of C,N-diphenylnitrone to methacrolein
    Daniel Carmona
    Departamento de Quimica Inorganica, Instituto de Ciencia de Materiales de Aragon, Universidad de Zaragoza Consejo Superior de Investigaciones Científicas, 50009 Zaragoza, Spain
    J Am Chem Soc 126:2716-7. 2004
    The 1,3-dipolar cycloaddition reaction of C,N-diphenylnitrone with methacrolein is efficiently catalyzed by the rhodium diphosphine compound (SRh,RC)-[(eta5-C5Me5)Rh(R-Prophos)(H2O)](SbF6)2 [R-Prophos = (R)-(+)-1,2-bis(diphenylphosphino)-..
  90. ncbi Rhodium-catalyzed arylative and alkenylative cyclization of 1,5-enynes induced by geminal carbometalation of alkynes
    Yiyun Chen
    Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA
    J Am Chem Soc 128:15598-9. 2006
    A rhodium(I)-catalyzed addition-cyclization of 1,5-enynes with aryl- and alkenylboronic acids has been developed...
  91. ncbi Addition of alkynes to aldehydes and activated ketones catalyzed by rhodium-phosphine complexes
    Pawan K Dhondi
    Department of Chemistry, 1 014 Center for Science and Technology, Syracuse University, Syracuse, New York 13244, USA
    J Org Chem 72:9590-6. 2007
    A mixture of 2-(di-tert-butylphosphino)biphenyl and dicarbonylacetonato rhodium(I) provides an effective catalyst system for the addition of alkynes to aldehydes and activated ketones...
  92. ncbi Synthesis and application of phosphinoferrocenylaminophosphine ligands for asymmetric catalysis
    Neil W Boaz
    Research Laboratories, Eastman Chemical Company, P O Box 1972, Kingsport, Tennessee 37662, USA
    J Org Chem 70:1872-80. 2005
    ..The rhodium complexes of these ligands show exceedingly high enantioselectivities (generally >95% ee) and activities often ..
  93. ncbi Stereochemical features making deoxycholic acid derived tropos biphenylphosphites efficient chiral ligands for rhodium: the asymmetric hydrogenation of dimethylitaconate as a case study
    Anna Iuliano
    Dipartimento di Chimica e Chimica Industriale, Universita di Pisa, Via Risorgimento 35, 56126 Pisa, Italy
    J Org Chem 72:8472-7. 2007
    ..acid derived biphenylphosphites, whose tropos nature was ascertained by NMR and CD measurements, were used in the rhodium-catalyzed asymmetric hydrogenation of dimethylitaconate achieving enantiomeric excesses up to 91%...
  94. ncbi Highly enantioselective Rh-catalyzed hydrogenation based on phosphine-phosphite ligands derived from carbohydrates
    O Pàmies
    Departament de Quimica Fisica i Inorganica, Universitat Rovira i Virgili, Pl Imperial Tarraco 1, 43005 Tarragona, Spain
    J Org Chem 66:8364-9. 2001
    ..on intermediates of the catalytic cycle show that the [Rh(P(1)-P(2))(enamide)]BF(4) species is the resting state and that the rate dependence is first order in rhodium and hydrogen pressure and zero order in enamide concentration.
  95. ncbi Theoretical elucidation of the rhodium-catalyzed [4 + 2] annulation reactions
    Cai Yun Geng
    State Key Laboratory of Theoretical and Computational Chemistry, Institute of Theoretical Chemistry, Jilin University, Changchun 130023, People s Republic of China
    J Comput Chem 29:686-93. 2008
    ....
  96. ncbi A one-pot synthesis of (E)-disubstituted alkenes by a bimetallic [Rh-Pd]-catalyzed hydrosilylation/hiyama cross-coupling sequence
    Carine Thiot
    Laboratoire de Synthese Bio Organique, Universite Louis Pasteur, Faculte de Pharmacie, 74 route du Rhin, 67401 Illkirch Graffenstaden, France
    Chemistry 13:8971-8. 2007
    ..Its catalytic activity was evaluated by rhodium-catalyzed hydrosilylation (H), palladium-catalyzed Hiyama coupling (C), and in the one-pot hydrosilylation/Hiyama ..
  97. ncbi Rh-catalyzed highly enantioselective formation of functionalized cyclopentanes and cyclopentanones
    Fei Liu
    College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, P R China
    Org Biomol Chem 5:3531-4. 2007
    ..were obtained from readily available starting materials in high yields and selectivities. Both regioselectivities and enantioselectivities are excellent: only 1,4-dienes were observed and in over 99% ee...
  98. ncbi Bis-(2,5-diphenylphospholanes) with sp2 carbon linkers: synthesis and application in asymmetric hydrogenation
    Martin E Fox
    Dowpharma, Chirotech Technology Ltd, A Subsidiary of The Dow Chemical Company, Unit 162 Cambridge Science Park, Milton Road, Cambridge, CB4 0GH, UK
    J Org Chem 73:775-84. 2008
    ..maleic anhydride ((S,S)-Ph-MalPhos), and 1,1'-ferrocene ((S,S)-Ph-5-Fc) were synthesized, and their cationic [rhodium(I)(COD)] complexes were prepared...
  99. ncbi Asymmetric hydroformylation with highly crosslinked polystyrene-supported (R,S)-BINAPHOS-Rh(I) complexes: the effect of immobilization position
    Fumitoshi Shibahara
    Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Hongo Bunkyo ku, Japan
    Bioorg Med Chem Lett 12:1825-7. 2002
    ..Using its Rh(I) complex, asymmetric hydroformylation of olefins proceeded with higher enantioselectivity in some cases compared to the conventional polymer-supported 1c...
  100. ncbi A rhodium(I)-catalyzed formal allenic Alder ene reaction for the rapid and stereoselective assembly of cross-conjugated trienes
    Kay M Brummond
    Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Am Chem Soc 124:15186-7. 2002
    A rhodium(I)-catalyzed allenic Alder ene reaction to prepare cross-conjugated trienes has been discovered. The scope and limitations are currently being investigated, and the results obtained to date are reported on...
  101. ncbi Balance between allylic C-H activation and cyclopropanation in the reactions of donor/acceptor-substituted rhodium carbenoids with trans-alkenes
    Huw M L Davies
    Department of Chemistry, University of Buffalo, The State University of New York, Buffalo, New York 14260 3000, USA
    Org Lett 9:4971-4. 2007
    b>Rhodium(II)-catalyzed reactions of aryldiazoacetates with (E)-aryl-substituted alkenes generate C-H insertion products and/or cyclopropanes...

Research Grants62

  1. Catalytic, Regioselective C-H Activation/Oxidation of Substituted Arenes
    Erin Burger; Fiscal Year: 2007
    ..Reports on highly regioselective rhodium (III) catalyzed reactions have also led us to propose the development of new methodology for the rhodium-..
  2. DNA Charge Transport Chemistry &Biology
    Jacqueline K Barton; Fiscal Year: 2012
    ..examine the distance range over which oxidative damage is funneled to a control sequence in mitochondria using rhodium photooxidants to generate damage at distant sites...
  3. N-Heterocycles from Azides through Rhodium-Catalyzed Nitrenoid Transfer
    TOM GREGORY DRIVER; Fiscal Year: 2012
    ..We also showcase our new methods in succinct syntheses of multiple drug resistance (MDR) reversal agents. ..
  4. Rhodium(II)-based inhibitors for STAT family oncoproteins
    MATTHEW MINUS; Fiscal Year: 2013
    ..Thus, we will design rhodium-containing hybrid ligands that utilize cooperativity between organic and inorganic fragments to produce a more ..
  5. Polymer Membrane Ion/Gas/Polyion Sensors: New Frontiers
    Mark E Meyerhoff; Fiscal Year: 2013
    ..commercial biomedical grade heparin preparations using potentiometric polyanion sensor technology;2) the use of rhodium (III) metalloporphyrin complexes as the most selective binding agents discovered to date for preparing ..
  6. Mechanism and Development of Catalysts for the Synthesis of Amines, Ethers, and S
    John F Hartwig; Fiscal Year: 2013
    ..A third portion of the proposed research will focus on a recently discovered type of rhodium catalyst that promises to significantly increase the scope of alkene hydroaminations...
  7. Rhodium-Catalyzed 1,2-Addition of Pinacolboronic Esters into Ketones
    GARY MICHAEL GALLEGO; Fiscal Year: 2013
    ..date, only highly activated carbonyls have been shown to undergo 1,2- additions with organoboron compounds under rhodium-catalysis...
  8. Approaches for Directed Olefin Hydroamination
    Juana Du; Fiscal Year: 2013
    ..will include ruthenium complexes containing a tethered [unreadable],[unreadable]-bidentate ligand framework, rhodium complexes of bidentate, bisphosphine ligands, and chelate-stabilized, ?2-olefin palladium complexes...
  9. Catalytic C-C Bond Forming Hydrogenations.
    Michael J Krische; Fiscal Year: 2013
    ..Using cationic rhodium and iridium catalysts, we have found that diverse ?-unsaturated reactants reductively couple to carbonyl ..
  10. Natural product Synthesis by Rh Catalyzed {2+2+2} Cycloadditions
    Derek M Dalton; Fiscal Year: 2012
    ..Specifically the proposed research aims to extend the rhodium catalyzed [2+2+2] cycloaddition of alkenyl isocyanates with exogenous alkynes to include functionalized, highly ..
  11. ALKALOID SYNTHESIS USING ORGANORHODIUM CHEMISTRY
    MARIE KRAFFT; Fiscal Year: 1992
    ..of organorhodium chemistry in organic synthesis and the demonstration of the power and versatility of a new rhodium based olefin functionalization reaction which was recently discovered in our laboratories...
  12. SELECTIVE METHODS FOR SYNTHESIS WITH STRAINED MOLECULES AND CARBENOIDS
    Joseph M Fox; Fiscal Year: 2012
    ..goal of the proposed research is to develop selective methods for organic synthesis with strained molecules and rhodium carbenoids...
  13. NEW STRATEGIES FOR GLYCOCONJUGATE SYNTHESIS FROM ALKYNES
    Frank McDonald; Fiscal Year: 1999
    ..This application also features the rhodium-catalyzed cyclotrimerization of alkynyl-carbohydrates...
  14. CHIRAL PHOSPHORUS LIGANDS AND ANTISENSE OLIGONUCLEOTIDES
    William Hersh; Fiscal Year: 1999
    ..starting materials will give rise to mixed phosphine/sulfonylphosphoramides that will be of primary interest in rhodium-catalyzed asymmetric hydroformylation reactions...
  15. Catalytic hydroacylation: Transforming C-H bonds into biorelevant esters and keto
    VY M DONG; Fiscal Year: 2013
    ..the practical value, this project will provide fundamental insights into the use of various catalysts, including rhodium, ruthenium, cobalt, and nickel, for the activation and functionalization of carbon-hydrogen bonds-a long standing ..
  16. DNA DAMAGE, REPAIR, AND MUTAGENESIS
    IRWIN TESSMAN; Fiscal Year: 1992
    ..of DNA in the presence of certain potential DNA binding compound such as urocanic acid present on human skin or potential photochemotherapeutic compounds like cis-bis(phenanthroline) rhodium chloride, an analog of "cis-platinum".
  17. Use of Silyl Glyoxylates in Tandem Vinylation/Brook Rearrangement/Adol Reactions
    REBECCA CUELLAR; Fiscal Year: 2007
    ..g. tiglic aldehyde) followed by enantioselective hydroxyl-directed hydrogenation using cationic rhodium or iridium species; [unreadable] [unreadable] iv) utilize the aforementioned methodology in the most concise ..
  18. Rhodium(III)-catalyzed arylation and alkenylation of imines by C-H functionalizat
    MICHAEL ANDREW ISCHAY; Fiscal Year: 2012
    ..Recently, transition metals such as rhodium have found application in directed C-H functionalization reactions...
  19. STRUCTURAL AND REACTIVITY OF IRON AND COBALT COMPLEXES
    VIRGIL GOEDKEN; Fiscal Year: 1980
    ..study of the reactivity of a broad class of metal complexes of iron and cobalt (and their congeners ruthenium and rhodium) which may serve as models for their naturally occurring biological counterparts...
  20. NEW FLUORESCENT X-RAY TUBES FOR MAMMOGRAPHY
    G Johnson; Fiscal Year: 1980
    ..b>Rhodium and palladium anodes have been constructed by depositing thin film on graphite and copper substrates...
  21. Self-Assembled Solutions to Asymmetric Hydrogenation
    JAMES TAKACS; Fiscal Year: 2005
    ..I application focuses on the design, preparation and evaluation of such libraries in five substrate classes of rhodium-catalyzed asymmetric hydrogenation...
  22. Enantioselective Zwitterionic Reactions
    HUW M DAVIES; Fiscal Year: 2013
    ..b>Rhodium-stabilized carbenoids containing both donor and acceptor groups are capable of a range of synthetically useful ..
  23. COMBINATORIAL SYNTHESIS OF PHOSPHINE LIGANDS
    Scott Gilbertson; Fiscal Year: 2003
    ..Initially three reactions will be screened, palladium catalyzed pi-allyl alkylation, the Heck reaction and a rhodium catalyzed [4+2] cycloisomerization reaction...
  24. Tetrahydronaphthylamines as Medications for Drug Abuse
    PHILLIP PELPHREY; Fiscal Year: 2007
    ..The proposed synthetic strategy involves the use of a rhodium catalyzed, C-H insertion/Cope rearrangement-elimination reaction previously developed in the Davies laboratory to ..
  25. SERT/NET Inhibitors as Medications for Drug Addiction
    James Manning; Fiscal Year: 2007
    ..The methodology to be used involves a rhodium catalyzed, tandem C-H insertion/Cope rearrangement reaction that has been previously developed to rapidly ..
  26. Regio-and Enantioselective Hydroformylation of Olefins
    Andrew Duncan; Fiscal Year: 2003
    ..The research plan described herein proposes the use of well-defined Lewis acid-modified rhodium(I) catalysts for highly regio- and enantioselective hydroformylation of functionalized olefins...
  27. SYNTHESIS OF FUSED HETEROCYCLIC COMPOUNDS
    Albert Padwa; Fiscal Year: 2002
    ..The generation of biologically active compounds by new synthetic methods remains an important part of both health related and chemical research. ..
  28. HETEROCYCLIC RING COMPOUNDS FOR ALKALOID SYNTHESIS
    Albert Padwa; Fiscal Year: 2007
    ..The generation of biologically active compounds by new synthetic methods remains an important part of both health related and chemical research. ..
  29. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  30. SYNTHETIC STUDIES RELATED TO CANCER RESEARCH/TREATMENT
    Paul Wender; Fiscal Year: 2005
    ..Overall, this research program is expected to be of significant value in chemistry, biology, and medicine. ..
  31. Allenic [2 + 2 + 1] Reactions Enabling Syntheses of Natural Products with 7-Membe
    Kay M Brummond; Fiscal Year: 2010
    ..Grayanotoxin is an important molecular tool for deciphering the mechanism for gating functions of the sodium ion channels. ..
  32. Application of C-H Activation to Natural Product Synthesis
    HUW M DAVIES; Fiscal Year: 2010
    ..This proposal is centered around a recently discovered highly stereoselective rhodium-catalyzed C-H activation process, the combined C-H activation/Cope rearrangement...
  33. Design of New Treatment Agents for Drug Abuse
    HUW M DAVIES; Fiscal Year: 2010
    ..This will be achieved through a multidisciplinary research program combining organic synthesis, medicinal chemistry, pharmacology and behavioral physiology, exploring the efficacy of a new class of 5HT2A receptor antagonists. ..
  34. CHIRAL CATALYSTS FOR ENANTIOSELECTIVE SYNTHESES
    Michael Doyle; Fiscal Year: 2002
    ..4 percent ee). Finally, enantioselective cyclopropanation with diazo-methane, which has been elusive, will be examined in critical detail using chiral copper(I) and dirhodium(II) catalysts. ..
  35. PHYSIOLOGICALLY ACTIVE NATURAL PRODUCTS
    Douglass Taber; Fiscal Year: 2007
    ..In the course of these investigations, new molecular reactivity will be developed that will substantially shorten current routes to polycyclic natural products and drug candidates. ..
  36. SYNTHESIS AND EVALUATION OF NOVEL COCAINE ANALOGS
    Huw Davies; Fiscal Year: 2002
    ..The proposed studies will ensure that a greater structural diversity is brought into the types of compounds that will be considered as potential medications for the treatment of cocaine addiction. ..
  37. Methylphenidate Analogs as Medications for Cocaine Abuse
    Huw Davies; Fiscal Year: 2006
    ..Initial studies will also be carried out to determine if useful PET radioligands can be made from any potent and selective analogs that are discovered during these studies. ..
  38. NEW RHODIUM-CATALYZED ALLYLIC ALKYLATION REACTIONS
    P Evans; Fiscal Year: 2006
    The aim of the following proposal is the development of the regio- and enantiospecific rhodium-catalyzed allylic substitution as a general cross-coupling reaction, and the combination with free radical cyclization and novel metal-..
  39. STEREOSELECTIVE SYNTHESIS OF CYCLIC ETHERS
    P Evans; Fiscal Year: 2006
    ..Finally, we will examine a series bismuth-catalyzed bis-reductive etherification reactions for the construction of linear fused polycyclic ethers. ..
  40. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  41. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..for their total synthesis, one following an intramolecular Diels-Alder approach and the other involving a rhodium-catalyzed carbenoid generation and addition to a double bond followed by a divinylcyclopropane [3...
  42. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  43. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  44. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  45. ASYMMETRIC SYNTHESIS OF IONOPHORE/MACROLIDE ANTIBIOTICS
    David Evans; Fiscal Year: 2005
    ..Our goal has been to set in place all of the reactions necessary for the rapid assemblage of any polyketide target structure. ..
  46. Asymmetric Synthesis of Amino Acids and Amino Phosphonic Acids
    FRANKLIN DAVIS; Fiscal Year: 2007
    ..The photodesulfmylation of sulfinamides represents an important new protocol, not requiring acids or bases, for the removal of the valuable amine N-sulfinyl protecting group. ..
  47. ASYMMETRIC SYNTHESIS OF VANCOMYCIN ANTIBIOTICS
    David Evans; Fiscal Year: 2001
    ..During the course of this project we intend to confirm (correct) the absolute stereochemical assignments of the principal members of this family by total synthesis. ..
  48. Breast CT scanner for earlier cancer detection
    John Boone; Fiscal Year: 2002
    ..that particularly warrant screening using breast CT. The Phase II trial will shed more light on this issue. ..
  49. Agilent 5973 GC/MS System
    GARY MOLANDER; Fiscal Year: 2002
    ..Our current lack of such instrumentation negatively affects the ability to carry out many of these studies. This critical capability, in the form of an instrument for everyday analysis, is urgently needed. ..
  50. NEW STRATEGIES FOR GLYCOCONJUGATE SYNTHESIS
    Frank McDonald; Fiscal Year: 2005
    ....
  51. Natural Product Leads for Drug Development
    KATHLYN PARKER; Fiscal Year: 2009
    ..Molecular modeling will allow the design of candidates for more active drugs. Candidates will be evaluated in the squalene synthase assay. Collaborations for the medicinal chemistry components of the project have been arranged. ..
  52. Hybrid Nuclear/X-ray Projection System for Mouse Imaging
    John Boone; Fiscal Year: 2005
    ..abstract_text> ..
  53. Tandem Cycloaddition Chemistry of 2-Azoniaheterodienes
    SCOTT DENMARK; Fiscal Year: 2007
    ..abstract_text> ..
  54. ORGANOMETALLIC SYNTHESES OF BIOACTIVE COMPOUNDS
    LOUIS HEGEDUS; Fiscal Year: 2003
    ..abstract_text> ..
  55. Resolution requirements for mammographic displays
    Ehsan Samei; Fiscal Year: 2004
    ..The results will be used to formulate recommendations to the breast imaging community concerning display resolution criteria for safe and optimized soft-copy display of digital mammograms. ..
  56. Bi-Plane Correlation Imaging: Detection of Lung Cancer
    Ehsan Samei; Fiscal Year: 2007
    ..The findings will be used to substantiate the capability of BCI for improving the early detection of lung nodules and to optimize its performance on actual clinical cases. ..
  57. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2005
    ..4) Carbometalation/cyclization reactions will be explored utilizing organochromium species. 5) Ligands and catalytic systems designed for asymmetric synthesis will be explored. ..
  58. An Automated System for Breast Cancer Biomarker Analysis
    John J Heine; Fiscal Year: 2010
    ..This work will produce a calibrated automated density assessment package that may be easily implemented across institutions without modifications for use in the FFDM systems that is tailored for tissue-related risk research. ..
  59. Synthesis of Polyketides and Terpenes
    David A Evans; Fiscal Year: 2010
    ..As a consequence, organic synthesis is a critical discipline that continues to have an important impact on the fields of both medicine and biology. ..