nickel

Summary

Summary: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.

Top Publications

  1. ncbi An overview of nickel-titanium alloys used in dentistry
    S A Thompson
    Department of Adult Dental Health, University of Wales College of Medicine, Cardiff, UK
    Int Endod J 33:297-310. 2000
  2. pmc Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium
    Konstantin Salnikow
    National Cancer Institute, Frederick, MD 21702, USA
    Chem Res Toxicol 21:28-44. 2008
  3. pmc Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans
    John T Murphy
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 7:e1002013. 2011
  4. ncbi Direct activation of transient receptor potential V1 by nickel ions
    Matthias Luebbert
    Lehrstuhl fur Zellphysiologie, Ruhr Universitat Bochum, Universitatsstr 150, 44780 Bochum, Germany
    Pflugers Arch 459:737-50. 2010
  5. ncbi Robust photogeneration of H2 in water using semiconductor nanocrystals and a nickel catalyst
    Zhiji Han
    Department of Chemistry, University of Rochester, Rochester, NY 14627, USA
    Science 338:1321-4. 2012
  6. pmc Cytosolic Ni(II) sensor in cyanobacterium: nickel detection follows nickel affinity across four families of metal sensors
    Andrew W Foster
    Biophysical Sciences Institute, Department of Chemistry, School of Biological and Biomedical Sciences, University of Durham, Durham DH1 3LE, United Kingdom
    J Biol Chem 287:12142-51. 2012
  7. ncbi Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel
    Marc Schmidt
    Department of Dermatology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Nat Immunol 11:814-9. 2010
  8. pmc Exposure to nickel, chromium, or cadmium causes distinct changes in the gene expression patterns of a rat liver derived cell line
    Matthew G Permenter
    Excet, Inc, Fort Detrick, Maryland, United States of America
    PLoS ONE 6:e27730. 2011
  9. ncbi Melatonin protects against Nickel-induced neurotoxicity in vitro by reducing oxidative stress and maintaining mitochondrial function
    Shang Cheng Xu
    Department of Occupational Health, Third Military Medical University, Chongqing, China
    J Pineal Res 49:86-94. 2010
  10. pmc A novel class of modular transporters for vitamins in prokaryotes
    Dmitry A Rodionov
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Bacteriol 191:42-51. 2009

Detail Information

Publications396 found, 100 shown here

  1. ncbi An overview of nickel-titanium alloys used in dentistry
    S A Thompson
    Department of Adult Dental Health, University of Wales College of Medicine, Cardiff, UK
    Int Endod J 33:297-310. 2000
    The nickel-titanium alloy Nitinol has been used in the manufacture of endodontic instruments in recent years. Nitinol alloys have greater strength and a lower modulus of elasticity compared with stainless steel alloys...
  2. pmc Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium
    Konstantin Salnikow
    National Cancer Institute, Frederick, MD 21702, USA
    Chem Res Toxicol 21:28-44. 2008
    Chronic exposure to nickel(II), chromium(VI), or inorganic arsenic (iAs) has long been known to increase cancer incidence among affected individuals...
  3. pmc Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans
    John T Murphy
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 7:e1002013. 2011
    ..Supporting this hypothesis, we demonstrated that dietary histidine promotes zinc tolerance. Nickel is another metal that binds histidine with high affinity...
  4. ncbi Direct activation of transient receptor potential V1 by nickel ions
    Matthias Luebbert
    Lehrstuhl fur Zellphysiologie, Ruhr Universitat Bochum, Universitatsstr 150, 44780 Bochum, Germany
    Pflugers Arch 459:737-50. 2010
    ..0-6.5) were augmented by low doses of NiSO4. In contrast, responses to stronger stimuli were reduced by NiSO4. Moreover, we were able to identify amino acids involved in the effect of NiSO4 on TRPV1...
  5. ncbi Robust photogeneration of H2 in water using semiconductor nanocrystals and a nickel catalyst
    Zhiji Han
    Department of Chemistry, University of Rochester, Rochester, NY 14627, USA
    Science 338:1321-4. 2012
    ..5, which gives >600,000 turnovers. Under appropriate conditions, the precious-metal-free system has undiminished activity for at least 360 hours under illumination at 520 nanometers and achieves quantum yields in water of over 36%...
  6. pmc Cytosolic Ni(II) sensor in cyanobacterium: nickel detection follows nickel affinity across four families of metal sensors
    Andrew W Foster
    Biophysical Sciences Institute, Department of Chemistry, School of Biological and Biomedical Sciences, University of Durham, Durham DH1 3LE, United Kingdom
    J Biol Chem 287:12142-51. 2012
    ..we show that the product of ORF sll0176, which encodes a CsoR/RcnR-like protein now designated InrS (for internal nickel-responsive sensor), represses nrsD (NrsD is deduced to efflux Ni(II) across the inner membrane) from a cryptic ..
  7. ncbi Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel
    Marc Schmidt
    Department of Dermatology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Nat Immunol 11:814-9. 2010
    Allergies to nickel (Ni(2+)) are the most frequent cause of contact hypersensitivity (CHS) in industrialized countries. The efficient development of CHS requires both a T lymphocyte-specific signal and a proinflammatory signal...
  8. pmc Exposure to nickel, chromium, or cadmium causes distinct changes in the gene expression patterns of a rat liver derived cell line
    Matthew G Permenter
    Excet, Inc, Fort Detrick, Maryland, United States of America
    PLoS ONE 6:e27730. 2011
    Many heavy metals, including nickel (Ni), cadmium (Cd), and chromium (Cr) are toxic industrial chemicals with an exposure risk in both occupational and environmental settings that may cause harmful outcomes...
  9. ncbi Melatonin protects against Nickel-induced neurotoxicity in vitro by reducing oxidative stress and maintaining mitochondrial function
    Shang Cheng Xu
    Department of Occupational Health, Third Military Medical University, Chongqing, China
    J Pineal Res 49:86-94. 2010
    b>Nickel is a potential neurotoxic pollutant. Oxidative stress is supposed to be involved in the mechanism underlying nickel-induced neurotoxicity...
  10. pmc A novel class of modular transporters for vitamins in prokaryotes
    Dmitry A Rodionov
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Bacteriol 191:42-51. 2009
    ..The shared use of energy-coupling modules was experimentally confirmed for folate, thiamine, and riboflavin transporters. We propose the name energy-coupling factor transporters for the new class of membrane transporters...
  11. pmc Cytotoxicity of nickel zinc ferrite nanoparticles on cancer cells of epithelial origin
    Mothanna Sadiq Al-Qubaisi
    Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia
    Int J Nanomedicine 8:2497-508. 2013
    In this study, in vitro cytotoxicity of nickel zinc (NiZn) ferrite nanoparticles against human colon cancer HT29, breast cancer MCF7, and liver cancer HepG2 cells was examined...
  12. ncbi Hydrogenase activity in the foodborne pathogen Campylobacter jejuni depends upon a novel ABC-type nickel transporter (NikZYXWV) and is SlyD-independent
    Robert M Howlett
    Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield, UK
    Microbiology 158:1645-55. 2012
    ..single membrane-bound, periplasmic-facing NiFe uptake hydrogenase that depends on the acquisition of environmental nickel for activity...
  13. pmc Specific metal recognition in nickel trafficking
    Khadine A Higgins
    Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Biochemistry 51:7816-32. 2012
    b>Nickel is an essential metal for a number of bacterial species that have developed systems for acquiring, delivering, and incorporating the metal into target enzymes and controlling the levels of nickel in cells to prevent toxic effects...
  14. ncbi Nickel-induced oxidative stress and effect of antioxidants in human lymphocytes
    Chang Yu Chen
    Department of Medical Technology, Fooyin University, Kaohsiung, Taiwan, Republic of China
    Arch Toxicol 77:123-30. 2003
    The purpose of this study was to evaluate the oxidative effect in human lymphocytes after acute nickel (Ni) treatment for 1 h; levels of intracellular reactive oxygen species (ROS), lipid peroxidation (LPO) and hydroxyl radicals ((*)OH) ..
  15. pmc Nickel-mediated oxidative fluorination for PET with aqueous [18F] fluoride
    Eunsung Lee
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    J Am Chem Soc 134:17456-8. 2012
    A one-step oxidative fluorination for carbon-fluorine bond formation from well-defined nickel complexes with oxidant and aqueous fluoride is presented, which enables a straightforward and practical (18)F late-stage fluorination of complex ..
  16. ncbi Nickel carcinogenesis
    Kazimierz S Kasprzak
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702 1201, USA
    Mutat Res 533:67-97. 2003
    Human exposure to highly nickel-polluted environments, such as those associated with nickel refining, electroplating, and welding, has the potential to produce a variety of pathologic effects...
  17. ncbi Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein
    M A Goldberg
    Howard Hughes Medical Institute, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115
    Science 242:1412-5. 1988
    ..Hypoxia, cobalt chloride, and nickel chloride appear to stimulate Epo production through a common pathway...
  18. ncbi Mechanical response of nickel-titanium instruments with different cross-sectional designs during shaping of simulated curved canals
    H C Kim
    Department of Conservative Dentistry, School of Dentistry, Pusan National University, Busan, Korea
    Int Endod J 42:593-602. 2009
    To evaluate how different cross-sectional designs affect stress distribution in nickel-titanium (NiTi) instruments during bending, torsion and simulated shaping of a curved canal.
  19. ncbi The key nickel enzyme of methanogenesis catalyses the anaerobic oxidation of methane
    Silvan Scheller
    Laboratory of Organic Chemistry, ETH Zurich, Wolfgang Pauli Str 10, 8093 Zurich, Switzerland
    Nature 465:606-8. 2010
    ..oxidation of methane might proceed as the reverse of archaeal methanogenesis from carbon dioxide with the nickel-containing methyl-coenzyme M reductase (MCR) as the methane-activating enzyme...
  20. ncbi Preferential usage of TCR-Vbeta17 by peripheral and cutaneous T cells in nickel-induced contact dermatitis
    L Büdinger
    Department of Dermatology, Rheinisch Westfalische Technische Hochschule, Aachen, Germany
    J Immunol 167:6038-44. 2001
    b>Nickel (Ni) is one of the most common contact sensitizers in man, and Ni-induced contact dermatitis is considered as a model of hapten-induced delayed type hypersensitivity...
  21. pmc The novel Helicobacter pylori CznABC metal efflux pump is required for cadmium, zinc, and nickel resistance, urease modulation, and gastric colonization
    Frank Nils Stähler
    Department of Microbiology and Hygiene, Institute of Medical Microbiology and Hygiene, University Hospital Freiburg, Hermann Herder Str 11, D 79104 Freiburg, Germany
    Infect Immun 74:3845-52. 2006
    ..Iron, copper, and nickel homeostasis has recently been demonstrated to be required for the establishment of H...
  22. pmc Nickel, cobalt, chromium, palladium and gold induce a mixed Th1- and Th2-type cytokine response in vitro in subjects with contact allergy to the respective metals
    J T Minang
    Department of Immunology, Stockholm University, Stockholm, Sweden
    Clin Exp Immunol 146:417-26. 2006
    b>Nickel (Ni), the main cause of contact allergy to metals, induces in vitro production of both Th1- and Th2-type cytokines in peripheral blood mononuclear cells (PBMC) from allergic subjects...
  23. pmc Comparative genomic analyses of nickel, cobalt and vitamin B12 utilization
    Yan Zhang
    Department of Biochemistry and Redox Biology Center, University of Nebraska, Lincoln, NE 68588 0664, USA
    BMC Genomics 10:78. 2009
    b>Nickel (Ni) and cobalt (Co) are trace elements required for a variety of biological processes. Ni is directly coordinated by proteins, whereas Co is mainly used as a component of vitamin B12...
  24. pmc Long-term inhalation exposure to nickel nanoparticles exacerbated atherosclerosis in a susceptible mouse model
    Gi Soo Kang
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, USA
    Environ Health Perspect 119:176-81. 2011
    ....
  25. ncbi Pulmonary and systemic toxicity following exposure to nickel nanoparticles
    James I Phillips
    National Institute for Occupational Health, National Health Laboratory Service, Johannesburg, Republic of South Africa
    Am J Ind Med 53:763-7. 2010
    ..The subject, a 38-year-old previously healthy male, inhaled nanoparticles of nickel while spraying nickel onto bushes for turbine bearings using a metal arc process...
  26. pmc Efficacy of simple short-term in vitro assays for predicting the potential of metal oxide nanoparticles to cause pulmonary inflammation
    Senlin Lu
    University of Edinburgh, Edinburgh, UK
    Environ Health Perspect 117:241-7. 2009
    ..There has been concern regarding risks from inhalation exposure to nanoparticles (NPs). The large number of particles requiring testing means that alternative approaches to animal testing are needed...
  27. ncbi Nickel decreases cellular iron level and converts cytosolic aconitase to iron-regulatory protein 1 in A549 cells
    Haobin Chen
    Nelson Institute of Environmental Medicine, New York University, School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Toxicol Appl Pharmacol 206:275-87. 2005
    b>Nickel (Ni) compounds are well-established carcinogens and are known to initiate a hypoxic response in cells via the stabilization and transactivation of hypoxia-inducible factor-1 alpha (HIF-1alpha)...
  28. ncbi Metals and women's health
    M Vahter
    Institute of Environmental Medicine, Karolinska Institutet, Sweden
    Environ Res 88:145-55. 2002
    ..The present work aims at reviewing exposure and health effects of cadmium, nickel, lead, mercury, and arsenic manifested differently in women than in men...
  29. ncbi Acute toxicity and gastroprotective effect of the Schiff base ligand ¹H-indole-3-ethylene-5-nitrosalicylaldimine and its nickel (II) complex on ethanol induced gastric lesions in rats
    Mohamed Mustafa Ibrahim
    Department of Chemistry, University of Hail, Hail 81451, Saudi Arabia
    Molecules 17:12449-59. 2012
    ..from the condensation reaction of tryptamine (an indole derivative) and 5-nitrosalicylaldehyde (TNS) and its nickel (II) complex against ethanol-induced gastric ulcer in rats...
  30. ncbi In vitro absorption of metal powders through intact and damaged human skin
    Francesca Larese Filon
    UCO Medicina del Lavoro Dipartimento di Scienze di Medicina Pubblica Università di Trieste, Via della Pieta 19, 34129 Trieste, Italy
    Toxicol In Vitro 23:574-9. 2009
    ..The aim of this study was to evaluate the percutaneous penetration of metal powders of cobalt (Co), nickel (Ni) and chromium (Cr) and the effect of skin lesions on skin absorption...
  31. pmc A cross-talk between NFAT and NF-κB pathways is crucial for nickel-induced COX-2 expression in Beas-2B cells
    Tongjian Cai
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Curr Cancer Drug Targets 11:548-59. 2011
    ..have shown that the exposure of Beas-2B cells, a human bronchial epithelial cell line, to lung carcinogenic nickel compounds results in increased COX-2 expression...
  32. ncbi Comparing the tolerance limits of selected bacterial and protozoan species to nickel in wastewater systems
    I Kamika
    Department of Environmental, Water and Earth Sciences, Faculty of Science, Tshwane University of Technology, Arcadia Campus, P Bag X680, Pretoria 0001, South Africa
    Sci Total Environ 410:172-81. 2011
    ..The tolerance limit of all isolates was significantly dependent on the pH and the temperature. The study suggests that these isolates can be used for the bioremediation of nickel in industrial wastewater systems.
  33. ncbi Recent progress in studies of metallic nickel and nickel-based nanoparticles' genotoxicity and carcinogenicity
    Ruth Magaye
    Department of Preventive Medicine of the Medical School, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Ningbo University, Ningbo, Zhejiang 315211, PR China
    Environ Toxicol Pharmacol 34:644-50. 2012
    Recently, nanoparticles have been the focus of many research and innovation. Metallic nickel and nickel-based nanoparticles are among those being exploited. Nickel fine particles are known to be genotoxic and carcinogenic...
  34. ncbi Fatigue resistance of engine-driven rotary nickel-titanium instruments produced by new manufacturing methods
    Gianluca Gambarini
    La Sapienza University, Rome, Italy
    J Endod 34:1003-5. 2008
    The aim of the present study was to investigate whether cyclic fatigue resistance is increased for nickel-titanium instruments manufactured by using new processes...
  35. ncbi Temperature variations at nano-scale level in phase transformed nanocrystalline NiTi shape memory alloys adjacent to graphene layers
    Abbas Amini
    Institute for Frontier Materials, Deakin University, Waurn Ponds, Geelong, VIC 3217, Australia
    Nanoscale 5:6479-84. 2013
    ..Larger superelastic deformations confirmed that the latent heat transfer through the deposited graphene layers allowed a larger phase transition volume and, therefore, more stress relaxation and penetration depth. ..
  36. pmc Hierarchical regulation of the NikR-mediated nickel response in Helicobacter pylori
    Cecile Muller
    Departement de Microbiologie, Institut Pasteur, Unité Pathogenèse de Helicobacter, Paris Cedex 15, France
    Nucleic Acids Res 39:7564-75. 2011
    b>Nickel is an essential metal for Helicobacter pylori, as it is the co-factor of two enzymes crucial for colonization, urease and hydrogenase...
  37. pmc Iron-containing urease in a pathogenic bacterium
    Eric L Carter
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 108:13095-9. 2011
    ..a gastric pathogen of ferrets, synthesizes a distinct iron-dependent urease in addition to its archetypical nickel-containing enzyme...
  38. ncbi Staying alive overdosed: how does Helicobacter pylori control urease activity?
    Kerstin Stingl
    Institut Pasteur, Unité de Pathogénie Bactérienne des Muqueuses, 28, rue du Dr Roux, F 75724 Paris, France
    Int J Med Microbiol 295:307-15. 2005
    Urease, a nickel metalloenzyme is an essential virulence factor of the gastric pathogen, Helicobacter pylori...
  39. pmc Toxicity and developmental defects of different sizes and shape nickel nanoparticles in zebrafish
    Cristina Ispas
    Department of Chemistry and Biomolecular Science, Center for Advanced Materials Processing CAMP, Clarkson University, Potsdam, New York 13699 5810, USA
    Environ Sci Technol 43:6349-56. 2009
    Metallic nanoparticles such as nickel are used in catalytic sensing, and electronic applications, but health and environmental affects have not been fully investigated...
  40. ncbi Carcinogenic nickel induces genes involved with hypoxic stress
    K Salnikow
    Nelson Institute of Environmental Medicine, and Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York 10016, USA
    Cancer Res 60:38-41. 2000
    Carcinogenic nickel compounds alter the program of gene expression in normal cells and induce a pattern of gene expression similar to that found in nickel-induced cancers...
  41. pmc Mechanisms of c-myc degradation by nickel compounds and hypoxia
    Qin Li
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, USA
    PLoS ONE 4:e8531. 2009
    b>Nickel (Ni) compounds have been found to cause cancer in humans and animal models and to transform cells in culture...
  42. ncbi Concentration of cadmium, nickel and aluminium in female breast cancer
    Hanna Romanowicz-Makowska
    Department of Pathology, Research Institute of Polish Mother s Memorial Hospital, Łódź, Poland
    Pol J Pathol 62:257-61. 2011
    The aim of this study was to investigate the cadmium (Cd), nickel (Ni) and aluminium (Al) concentrations in female breast cancer and normal tissue.
  43. ncbi Nickel compounds render anti-apoptotic effect to human bronchial epithelial Beas-2B cells by induction of cyclooxygenase-2 through an IKKbeta/p65-dependent and IKKalpha- and p50-independent pathway
    Jin Ding
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    J Biol Chem 281:39022-32. 2006
    The carcinogenicity of nickel compounds has been well documented both in vitro and in vivo; however, the molecular mechanisms by which nickel compounds cause cancers are far from understood...
  44. ncbi Nickel, its adverse health effects & oxidative stress
    K K Das
    Environmental Health Research Unit, Department of Physiology, Al Ameen Medical College, Bijapur, Karnataka, India
    Indian J Med Res 128:412-25. 2008
    b>Nickel-induced toxicity and carcinogenicity, with an emphasis on the generation and role of reactive oxygen species is reviewed...
  45. ncbi Structure of a nickel chaperone, HypA, from Helicobacter pylori reveals two distinct metal binding sites
    Wei Xia
    Department of Chemistry and Open Laboratory of Chemical Biology, University of Hong Kong, Pokfulam, Hong Kong, People s Republic of China
    J Am Chem Soc 131:10031-40. 2009
    ..They are required for the activation and maturation of nickel-containing enzymes [Ni,Fe]-hydrogenase and urease...
  46. ncbi Monitoring of lead, cadmium, chromium and nickel in placenta from an e-waste recycling town in China
    Yongyong Guo
    Analytical Cytology Laboratory, Shantou University Medical College, Guangdong, P R China
    Sci Total Environ 408:3113-7. 2010
    ..We aimed to investigate concentrations of heavy metals, including lead (Pb), cadmium (Cd), chromium (Cr), and nickel (Ni) in placenta from Guiyu and compared them with those from a control area where no e-waste processing occurs...
  47. ncbi Coordination modes of a schiff base pentadentate derivative of 4-aminoantipyrine with cobalt(II), nickel(II) and copper(II) metal ions: synthesis, spectroscopic and antimicrobial studies
    Sulekh Chandra
    Department of Chemistry, Zakir Husain College, University of Delhi, New Delhi, India
    Molecules 14:174-90. 2009
    ..The nickel(II) complexes were found to have octahedral geometry, whereas cobalt(II) and copper(II) complexes were of ..
  48. pmc Interplay of metal ions and urease
    Eric L Carter
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824 4320, USA
    Metallomics 1:207-21. 2009
    Urease, the first enzyme to be crystallized, contains a dinuclear nickel metallocenter that catalyzes the decomposition of urea to produce ammonia, a reaction of great agricultural and medical importance...
  49. pmc Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers
    Haobin Chen
    Department of Environmental Medicine, New York University of School of Medicine, New York, New York 10016, USA
    J Biol Chem 285:7374-83. 2010
    ..ABH2 as examples, we show that this family of dioxygenases is highly sensitive to inhibition by carcinogenic nickel ions...
  50. pmc Effects of nickel, chromate, and arsenite on histone 3 lysine methylation
    Xue Zhou
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, NY 10987, USA
    Toxicol Appl Pharmacol 236:78-84. 2009
    Occupational exposure to nickel (Ni), chromium (Cr), and arsenic (As) containing compounds has been associated with lung cancer and other adverse health effects...
  51. pmc Functional activity and role of cation-efflux family members in Ni hyperaccumulation in Thlaspi goesingense
    M W Persans
    Department of Chemistry, Northern Arizona University, Flagstaff 86011, USA
    Proc Natl Acad Sci U S A 98:9995-10000. 2001
    ..We propose that the high-level expression of TgMTP1 in T. goesingense accounts for the enhanced ability of this hyperaccumulator to accumulate metal ions within shoot vacuoles...
  52. ncbi Activation process of [NiFe] hydrogenase elucidated by high-resolution X-ray analyses: conversion of the ready to the unready state
    Hideaki Ogata
    Department of Life Science, Graduate School of Life Science, University of Hyogo and Himeji Institute of Technology, 3 2 1 Koto, Ako gun, Hyogo 678 1297, Japan
    Structure 13:1635-42. 2005
    ..These findings provide useful information on the design of new systems of biomimetic dihydrogen production and fuel cell devices...
  53. pmc Dependence of Helicobacter pylori urease activity on the nickel-sequestering ability of the UreE accessory protein
    Stephane Benoit
    Department of Microbiology, University of Georgia, Athens, Georgia 30602, USA
    J Bacteriol 185:4787-95. 2003
    ..in Escherichia coli, purified, and characterized, and three altered versions were expressed to address a nickel-sequestering role of UreE...
  54. pmc JNK1 mediates degradation HIF-1alpha by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70
    Dongyun Zhang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    Cancer Res 70:813-23. 2010
    ..Taken together, our studies define a novel function for JNK1 in regulating HIF-1alpha turnover by a VHL-independent mechanism...
  55. ncbi Nano-network electronic conduction in iron and nickel olivine phosphates
    P Subramanya Herle
    University of Waterloo, Department of Chemistry, 200 University Ave West, Waterloo Ontario Canada N2L 3G1
    Nat Mater 3:147-52. 2004
    ..We believe our demonstration of non-carbonaceous-network grain-boundary conduction to be the first in these materials, and that it holds promise for other insulating phosphates...
  56. pmc Lung cancer mortality in UK nickel-cadmium battery workers, 1947-2000
    T Sorahan
    Institute of Occupational Health, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Occup Environ Med 61:108-16. 2004
    To investigate mortality from lung cancer in nickel-cadmium battery workers in relation to cumulative exposure to cadmium hydroxide.
  57. pmc Identification of rcnA (yohM), a nickel and cobalt resistance gene in Escherichia coli
    Agnes Rodrigue
    Unité de Microbiologie et Génétique, Unité Mixte de Recherche 5122, Centre National de la Recherche Scientifique, Institut National des Sciences, Applquée de Lyon I, Villeurbanne, France
    J Bacteriol 187:2912-6. 2005
    ..We show that yohM encodes a membrane-bound polypeptide conferring increased nickel and cobalt resistance in E. coli...
  58. ncbi Oxidative stress mediated apoptosis induced by nickel ferrite nanoparticles in cultured A549 cells
    Maqusood Ahamed
    King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia
    Toxicology 283:101-8. 2011
    Due to the interesting magnetic and electrical properties with good chemical and thermal stabilities, nickel ferrite nanoparticles are being utilized in many applications including magnetic resonance imaging, drug delivery and ..
  59. ncbi Soluble nickel interferes with cellular iron homeostasis
    Todd Davidson
    Nelson Institute of Environmental Medicine, School of Medicine, New York University, Tuxedo, New York 10987, USA
    Mol Cell Biochem 279:157-62. 2005
    Soluble nickel compounds are likely human carcinogens. The mechanism by which soluble nickel may contribute to carcinogenesis is unclear, though several hypotheses have been proposed...
  60. ncbi Unusual ligand structure in Ni-Fe active center and an additional Mg site in hydrogenase revealed by high resolution X-ray structure analysis
    Y Higuchi
    Division of Chemistry, Graduate School of Science, Kyoto University, Japan
    Structure 5:1671-80. 1997
    ..These in turn will provide insight into the mechanism of electron transfer, during the reaction catalysed by hydrogenase...
  61. ncbi The effectiveness of manual and mechanical instrumentation for the retreatment of three different root canal filling materials
    Francesco Somma
    Department of Endodontics, Catholic University of Sacred Heart, Rome, Italy
    J Endod 34:466-9. 2008
    ..Both the engine-driven NiTi rotary systems proved to be safe and fast devices for the removal of endodontic filling material...
  62. ncbi A comparison of the efficacy of conventional and new retreatment instruments to remove gutta-percha in curved root canals: an ex vivo study
    G Celik Unal
    Department of Endodontics, Suleyman Demirel University, Isparta, Turkey
    Int Endod J 42:344-50. 2009
    ..To compare the efficacy of conventional and new retreatment instruments when removing gutta-percha root fillings in curved root canals...
  63. ncbi Surface characterizations and corrosion resistance of nickel-titanium orthodontic archwires in artificial saliva of various degrees of acidity
    Her Hsiung Huang
    Department of Chemical and Materials Engineering, National University of Kaohsiung, No 700, Kaohsiung University Road, Kaohsiung 811, Taiwan
    J Biomed Mater Res A 74:629-39. 2005
    This study investigated the surface characterizations and corrosion resistance of as-received commercial nickel-titanium (NiTi) dental orthodontic archwires from different manufacturers using a cyclic potentiodynamic test in artificial ..
  64. ncbi Cyclic fatigue resistance and three-dimensional analysis of instruments from two nickel-titanium rotary systems
    N M Grande
    Department of Endodontics, Catholic University of Sacred Heart, Rome, Italy
    Int Endod J 39:755-63. 2006
    To determine how instrument design affects the fatigue life of two nickel-titanium (Ni-Ti) rotary systems (Mtwo and ProTaper) under cyclic fatigue stress in simulated root canals.
  65. pmc Constitutively elevated salicylic acid signals glutathione-mediated nickel tolerance in Thlaspi nickel hyperaccumulators
    John L Freeman
    Center for Plant Environmental Stress Physiology, Purdue University, West Lafayette, Indiana 47907, USA
    Plant Physiol 137:1082-91. 2005
    Progress is being made in understanding the biochemical and molecular basis of nickel (Ni)/zinc (Zn) hyperaccumulation in Thlaspi; however, the molecular signaling pathways that control these mechanisms are not understood...
  66. pmc Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 117:587-96. 2009
    ..Oxidative stress and excitotoxicity underlie the developmental neurotoxicity of numerous chemicals...
  67. ncbi Genotoxic evaluation of welders occupationally exposed to chromium and nickel using the Comet and micronucleus assays
    K Danadevi
    Owaisi Hospital and Research Center, Deccan College of Medical Sciences, Hyderabad, Andhra Pradesh, India
    Mutagenesis 19:35-41. 2004
    Chromium (Cr) and nickel (Ni) are widely used industrial chemicals. Welders in India are inclined to possible occupational Cr and Ni exposure...
  68. ncbi Efficacy of three rotary NiTi instruments in removing gutta-percha from root canals
    T Tasdemir
    Department of Endodontics, Faculty of Dentistry, Karadeniz Technical University, Trabzon, Turkey
    Int Endod J 41:191-6. 2008
    To investigate the ability of three rotary nickel-titanium instruments and hand instrumentation to remove gutta-percha and sealer.
  69. pmc Ni(II) and Co(II) sensing by Escherichia coli RcnR
    Jeffrey S Iwig
    Washington University School of Medicine, Department of Biochemistry and Molecular Biophysics, Saint Louis, Missouri 63110, USA
    J Am Chem Soc 130:7592-606. 2008
    ..coli, to provide a better understanding how different nickel levels are sensed in E. coli...
  70. ncbi Wafer-scale synthesis and transfer of graphene films
    Youngbin Lee
    SKKU Advanced Institute of Nanotechnology SAINT and Center for Human Interface Nano Technology HINT, Sungkyunkwan University, Suwon 440 746, Korea
    Nano Lett 10:490-3. 2010
    ..1. These methods represent a significant step toward the realization of graphene devices in wafer scale as well as application in optoelectronics, flexible and stretchable electronics...
  71. ncbi Occupational toxicology of nickel and nickel compounds
    Jinshun Zhao
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Environ Pathol Toxicol Oncol 28:177-208. 2009
    b>Nickel and nickel compounds are widely used in industry. The high consumption of nickel products inevitably leads to occupational and environmental pollution...
  72. pmc Structural basis for the specialization of Nur, a nickel-specific Fur homolog, in metal sensing and DNA recognition
    Young Jun An
    Marine and Extreme Genome Research Center, Korea Ocean Research and Development Institute, Ansan 426 744, Republic of Korea
    Nucleic Acids Res 37:3442-51. 2009
    Nur, a member of the Fur family, is a nickel-responsive transcription factor that controls nickel homeostasis and anti-oxidative response in Streptomyces coelicolor. Here we report the 2.4-A resolution crystal structure of Nur...
  73. ncbi Copper inhibits the water and glycerol permeability of aquaporin-3
    Marina Zelenina
    Department of Woman and Child Health, Karolinska Institutet, Stockholm S 171 77, Sweden
    J Biol Chem 279:51939-43. 2004
    ..Our results provide a better understanding of processes that occur in severe copper metabolism defects such as Wilson disease and in copper poisoning...
  74. ncbi Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels
    Chien Chang Chen
    Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, USA
    Science 302:1416-8. 2003
    ..Furthermore, acute blockade of T-channels with Ni2+ prevented relaxation of wild-type coronary arteries. Thus, Ca2+ influx through alpha1H T-type Ca2+ channels is essential for normal relaxation of coronary arteries...
  75. ncbi Comparative study on the shaping ability and cleaning efficiency of rotary Mtwo instruments. Part 1. Shaping ability in simulated curved canals
    E Schafer
    Department of Operative Dentistry, University of Munster, Munster, Germany
    Int Endod J 39:196-202. 2006
    To compare the shaping ability of Mtwo instruments with K3 and RaCe instruments. Part 1 of this two-part report describes the efficacy of these nickel-titanium instruments in simulated curved root canals.
  76. ncbi Nickel and extracellular acidification inhibit the water permeability of human aquaporin-3 in lung epithelial cells
    Marina Zelenina
    Department of Woman and Child Health, Karolinska Institutet, S 171 76 Stockholm, Sweden
    J Biol Chem 278:30037-43. 2003
    b>Nickel is a common cause of pneumoconiosis. Here, we show that nickel inactivates aquaporin (AQP)-3, the water channel expressed apically in epithelial cells of human terminal airways...
  77. ncbi Factors influencing defects of rotary nickel-titanium endodontic instruments after clinical use
    Peter Parashos
    School of Dental Science, University of Melbourne, 711 Elizabeth Street, Melbourne, Victoria 3000, Australia
    J Endod 30:722-5. 2004
    This study examined used, discarded rotary nickel-titanium instruments obtained from 14 endodontists in four countries, and identified factors that may influence defects produced during clinical use...
  78. ncbi A nickel-cobalt-sensing ArsR-SmtB family repressor. Contributions of cytosol and effector binding sites to metal selectivity
    Jennifer S Cavet
    Biosciences, Medical School, University of Newcastle, Newcastle NE2 4HH, United Kingdom
    J Biol Chem 277:38441-8. 2002
    ..of a gene encoding a P(1) type ATPase (NmtA), repressing transcription in vivo except in medium supplemented with nickel or, to some extent, cobalt...
  79. ncbi Coselection for microbial resistance to metals and antibiotics in freshwater microcosms
    Ramunas Stepanauskas
    University of Georgia, Savannah River Ecology Laboratory, Aiken, SC, USA
    Environ Microbiol 8:1510-4. 2006
    ..Our results provide first experimental evidence that the exposure of freshwater environments to individual metals and antibiotics selects for multiresistant microorganisms, including opportunistic human pathogens...
  80. pmc Does the effect of PM10 on mortality depend on PM nickel and vanadium content? A reanalysis of the NMMAPS data
    Francesca Dominici
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21215, USA
    Environ Health Perspect 115:1701-3. 2007
    ..They found that average concentrations of nickel or vanadium in PM2.5 (PM with aerodynamic diameter < 2...
  81. ncbi Nickel induces oxidative burst, NF-κB activation and interleukin-8 production in human neutrophils
    Marisa Freitas
    REQUIMTE, Departamento de Quimica, Faculdade de Farmacia, Universidade do Porto, Rua Anibal Cunha, 164, 4099 030, Porto, Portugal
    J Biol Inorg Chem 15:1275-83. 2010
    Many lines of evidence have suggested that oxidative stress and inflammation play a pivotal role in the toxicity of nickel salts...
  82. pmc Elucidating the mechanisms of nickel compound uptake: a review of particulate and nano-nickel endocytosis and toxicity
    Alexandra Muñoz
    New York University School of Medicine, Nelson Institute of Environmental Medicine, 57 Old Forge Road, NY 10987, USA
    Toxicol Appl Pharmacol 260:1-16. 2012
    b>Nickel (Ni) is a worldwide pollutant and contaminant that humans are exposed to through various avenues resulting in multiple toxic responses - most alarming is its clear carcinogenic nature...
  83. ncbi Interference of nickel with copper and iron homeostasis contributes to metal toxicity symptoms in the nickel hyperaccumulator plant Alyssum inflatum
    Rasoul Ghasemi
    Department of Biology, University of Isfahan, Isfahan, Iran
    New Phytol 184:566-80. 2009
    ..transition metals in the development of metal toxicity symptoms in plants, the effects of exposure to excess nickel (Ni) on copper (Cu) and iron (Fe) homeostasis in the Ni hyperaccumulator plant Alyssum inflatum were examined...
  84. ncbi Cyclic fatigue testing and metallographic analysis of nickel-titanium rotary instruments
    Chiara Pirani
    Department of Dental Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy
    J Endod 37:1013-6. 2011
    The aim of this study was to compare cyclic fatigue resistance of four nickel-titanium rotary systems and to evaluate their surface, fractographic, and matrix morphology.
  85. ncbi A retrospective study of endodontic treatment outcome between nickel-titanium rotary and stainless steel hand filing techniques
    Gary S P Cheung
    Area of Endodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong
    J Endod 35:938-43. 2009
    ..The purpose of this study was to compare the periapical healing of molar root canal treatment using two instrumentation techniques...
  86. ncbi Nickel reactivity and filaggrin null mutations--evaluation of the filaggrin bypass theory in a general population
    Katrine Ross-Hansen
    Department of Dermato Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, 2900 Hellerup, Denmark
    Contact Dermatitis 64:24-31. 2011
    It was recently shown that filaggrin null mutation carrier status was associated with nickel allergy and self-reported intolerance to costume jewellery...
  87. ncbi Metal tolerating methylotrophic bacteria reduces nickel and cadmium toxicity and promotes plant growth of tomato (Lycopersicon esculentum L)
    M Madhaiyan
    Department of Agricultural Chemistry, Chungbuk National University, Cheongju, Chungbuk 361 763, Republic of Korea
    Chemosphere 69:220-8. 2007
    ....
  88. ncbi Interactive effect of calcium and gibberellin on nickel tolerance in relation to antioxidant systems in Triticum aestivum L
    Manzer H Siddiqui
    Department of Botany, College of Science, King Saud University, Riyadh, Saudi Arabia
    Protoplasma 248:503-11. 2011
    b>Nickel toxicity affects many metabolic facets of plants and induces anatomical and morphological changes resulting in reduced growth and productivity...
  89. ncbi Lifespan of one nickel-titanium rotary file with reciprocating motion in curved root canals
    Sung Yeop You
    Department of Conservative Dentistry, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea
    J Endod 36:1991-4. 2010
    The purpose of this study was to examine the lifespan of one nickel-titanium (NiTi) rotary file when used in reciprocating motion and to compare the time required for its preparation of a curved root canal using both reciprocating and ..
  90. ncbi Requirement of nickel metabolism proteins HypA and HypB for full activity of both hydrogenase and urease in Helicobacter pylori
    J W Olson
    Department of Microbiology, 813 Biological Sciences Building, University of Georgia, Athens, GA 30602, USA
    Mol Microbiol 39:176-82. 2001
    The nickel-containing enzymes hydrogenase and urease require accessory proteins in order to incorporate properly the nickel atom(s) into the active sites...
  91. ncbi Occupational exposure to arsenic, cadmium, chromium, lead and nickel, and renal cell carcinoma: a case-control study from Central and Eastern Europe
    Paolo Boffetta
    International Prevention Research Institute, 95 cours Lafayette, Lyon 69006, France
    Occup Environ Med 68:723-8. 2011
    ..To investigate the risk of renal cell carcinoma (RCC) in Central and Eastern Europe in relation to exposure to known and suspected carcinogenic metals...
  92. ncbi Structural and biological analysis of the metal sites of Escherichia coli hydrogenase accessory protein HypB
    Alistair V Dias
    Department of Chemistry, University of Toronto, Toronto, Ontario, Canada
    Biochemistry 47:11981-91. 2008
    ..X-ray absorption spectroscopy of purified proteins was used to examine the detailed coordination spheres of each nickel-loaded site...
  93. ncbi Mechanisms of cytotoxicity of nickel ions based on gene expression profiles
    Xiaoying Lu
    State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Si Pailou 2, Nanjing 210096, PR China
    Biomaterials 30:141-8. 2009
    ..Ni(II) has extensive effects on cells by inhibiting cell proliferation and differentiation through inducing cell apoptosis, affecting cell development and influencing cholesterol metabolism...
  94. ncbi In vitro evaluation of surface topographic changes and nickel release of lingual orthodontic archwires
    Carlos Suarez
    Division d Orthodontie, Section de Médecine Dentaire, Faculte de Medecine, Universite de Geneve, rue Barthélemy Menn, 19, 1205, Geneva, Switzerland
    J Mater Sci Mater Med 21:675-83. 2010
    The objective of the article is to study surface topographic changes and nickel release in lingual orthodontic archwires in vitro...
  95. ncbi Lung cancer risk associated with occupational exposure to nickel, chromium VI, and cadmium in two population-based case-control studies in Montreal
    Rachelle Beveridge
    Departement de Medecine sociale et preventive, Universite de Montreal, Montreal, QC, Canada
    Am J Ind Med 53:476-85. 2010
    b>Nickel, chromium VI, and cadmium have been identified as lung carcinogens in highly exposed cohorts...
  96. ncbi Nickel release from new conventional stainless steel, recycled, and nickel-free orthodontic brackets: An in vitro study
    Maria Francesca Sfondrini
    Department of Orthodontics, University of Pavia, Italy
    Am J Orthod Dentofacial Orthop 137:809-15. 2010
    The aim of this study was to compare the nickel released from 3 kinds of orthodontic brackets: new conventional stainless steel, recycled stainless steel, and nickel-free brackets.
  97. ncbi Comparison between a novel nickel-titanium alloy and 508 nitinol on the cyclic fatigue life of ProFile 25/.04 rotary instruments
    Eugenia Johnson
    Department of Endodontics, Nova Southeastern University College of Dental Medicine, Health Professions Division, Fort Lauderdale, FL 33328, USA
    J Endod 34:1406-9. 2008
    ..Data were recorded for torque and angle at fracture. Statistical differences were found with nickel-titanium variant 1B (M-Wire NiTi) nearly 400% more resistant to cyclic fatigue than stock ProFile 25/.04 (P < ...
  98. ncbi Three-phase metal kinetics in terrestrial invertebrates exposed to high metal concentrations
    Ryszard Laskowski
    Institute of Environmental Sciences, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Sci Total Environ 408:3794-802. 2010
    ..Using nickel toxicokinetics in carabid beetles and earthworms as examples, we showed that Ni in fact exhibits a three-phase ..
  99. ncbi The effect of ligation on the load deflection characteristics of nickel titanium orthodontic wire
    Shugo Kasuya
    Department of Orthodontic, Tsurumi University School of Dental Medicine, Yokohama, Japan
    Eur J Orthod 29:578-82. 2007
    This study examined the effect of ligation on the load-deflection characteristics of nickel-titanium (NiTi) orthodontic wire...
  100. ncbi Cyclic fatigue and fracture characteristics of ground and twisted nickel-titanium rotary files
    Hyeon Cheol Kim
    Department of Conservative Dentistry, School of Dentistry, Pusan National University, Busan, Korea
    J Endod 36:147-52. 2010
    The purposes of this study were to compare the fatigue resistance of traditional, ground nickel-titanium rotary instruments with the Twisted File and to examine the fracture characteristics of the fatigued fragment.
  101. ncbi Efficacy, cleaning ability and safety of different rotary NiTi instruments in root canal retreatment
    M Hulsmann
    Department of Operative Dentistry, Preventive Dentistry and Periodontology, University of Gottingen, Gottingen, Germany
    Int Endod J 37:468-76. 2004
    To evaluate the efficacy, cleaning ability and safety of three different rotary nickel-titanium instruments with and without a solvent (eucalyptol) versus hand files in the removal of gutta-percha root fillings.

Research Grants65

  1. Ultraprecision Diamond Machining of Conventional Non-Diamond Machinable Materials
    Gang Zhang; Fiscal Year: 2007
    ..It cannot machine many important materials such as ferrous alloys, stainless steel, titanium and nickel due to catastrophic diamond tool wear...
  2. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2013
    ..PM2.5 with Nickel or PM2.5 with vanadium will be compared to PM2.5 exposure alone to evaluate differences in biological responses...
  3. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
    ..The system entails using the low molecular weight polycation O10H6 as a DNA condensing agent on the surface of nickel-displaying PLGA particles...
  4. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2010
    ..PM2.5 with Nickel or PM2.5 with vanadium will be compared to PM2.5 exposure alone to evaluate differences in biological responses...
  5. Bangladesh Centre for Global Environmental and Occupational Health
    Dewan Shamsul Alam; Fiscal Year: 2013
    ..contamination, millions of Bangladeshis may also be exposed to unsafe levels of other toxic metals including lead, nickel, manganese, uranium and chromium...
  6. Reactive oxygen species in Ni(II) carcinogenesis
    Xianglin Shi; Fiscal Year: 2012
    b>Nickel-containing compounds are human carcinogens. The mechanisms of their carcinogenic actions remain to be investigated. Recent studies have indicated that reactive oxygen species (ROS) may play an important role...
  7. Black carbon exposure, DNA methylation, airway inflammation in pediatric asthma
    Rachel L Miller; Fiscal Year: 2013
    ..We hypothesize that exposure to BC, nickel (Ni), and vanadium (V) is associated with changes in buccal DNA methylation of proinflammatory asthma genes (..
  8. Plk3 in lung cancer
    Dazhong Xu; Fiscal Year: 2012
    ..Metal elements such as nickel promote lung cancers...
  9. A novel anti-spore nasal vaccine for protection from anthrax
    Amy Rasley; Fiscal Year: 2013
    ..We will leverage prior research in our laboratories, identifying spore-surface proteins and creating nickel-chelated nanolipoprotein particles, to generate nanoparticles bearing PA as well as at least three spore proteins ..
  10. Effects of Fine Particle Composition on Birth Outcomes
    Michelle L Bell; Fiscal Year: 2013
    ..5 chemical components (e.g., nickel);and 2) levels of PM2.5 from specific sources (e.g...
  11. Investigating Health Effects From Exposure to Organic Carbon and Nickel Aerosol
    Richard E Peltier; Fiscal Year: 2013
    ..Brionchial lavage fluid will be collected and centrifuged and the supernatant will be analyzed for biochemical indicators of lung injury (total protein and LDH) and inflammatory cytokines. ..
  12. Plk3, A New Player In The Hypoxia Regulatory Networ.
    Wei Dai; Fiscal Year: 2013
    ..we have shown that PLK3-/- MEFs are hyper-sensitive to the induction of HIF-11 under hypoxia or treated with nickel, a hypoxia mimetic...
  13. BIOLOGICALLY RELATED IRON-SULFUR CHEMISTRY
    RICHARD HADLEY HOLM; Fiscal Year: 2011
    ..understanding of biologically relevant cluster clusters containing iron, sulfur, and molybdenum, vanadium, or nickel, various types of which are found at all levels of life...
  14. Joules, Genes, and Behaviors: a multifactorial assessment of TMD risk indicators
    Jeffrey C Nickel; Fiscal Year: 2013
    ..occur in women compared to men and in a subject group with TMJ disc displacement (DD) compared to a healthy group (Nickel et al., 2009c). To be determined are duty factor of TMJ loading behaviors, e.g...
  15. ENZYMOLOGY OF THE REDUCTIVE ACETYL-COA PATHWAY
    STEPHEN WILEY RAGSDALE; Fiscal Year: 2013
    ..into the structures of macromolecular channels, previously unknown metal clusters, unusual roles of low-valent nickel and cobalt ions as nucleophiles, novel biochemical roles of Coenzyme A, organometallic complexes as intermediates ..
  16. Structural investigation of Helicobacter pylori transcription regulator NikR
    SARAH ELIZABETH JOHNSON BOWMAN; Fiscal Year: 2011
    ..The nickel-dependent regulatory protein, HpNikR, sits at the center of the regulatory network that is vital to ability of H...
  17. Effects of nanoparticle dispersion status on bioactivity and translocation in the
    TINA MARIE SAGER; Fiscal Year: 2013
    ..Positively and neutrally charged nickel and negatively charged cerium oxide will be suspended in four different dispersion media (PBS, DM, Survanta, ..
  18. 1/2 Air Pollution-Children's Health GEOHealth Hub in China: China
    Jingping Niu; Fiscal Year: 2013
    ..Preliminary data document especially high nickel exposures and increases in cardiovascular risk associated with proximity to the world's second largest nickel ..
  19. Role of Nrf2 in immunotoxicity by food additives and environmental contaminants
    CHERYL ELIZABETH ROCKWELL; Fiscal Year: 2013
    ..Nrf2 is activated by a variety of chemicals, including environmental contaminants such as arsenic, cadmium, nickel, cigarette smoke, and diesel exhaust, as well as industrial byproducts, such as tetrafluoroethylcysteine...
  20. Effecting C-O activation of oxazolidinones by Ni to construct small, chiral heter
    MATTHEW STEVEN WINSTON; Fiscal Year: 2012
    ..In this proposal, a novel nickel-catalyzed reaction will be developed to allow the fast, convenient construction of these functionalities from ..
  21. Use of Molecular Hydrogen by Salmonella typhimurium
    Robert J Maier; Fiscal Year: 2010
    ..The affects of nickel chelators (i.e...
  22. Investigation into Mechanisms NLRP3 Activation by Nickel Associated Multi-Walled
    TERI ALYN GIRTSMAN; Fiscal Year: 2013
    ..In preliminary data, we have shown that there may be a correlation between the ability of nickel associated MWCNT (Ni-MWCNT) to activate NLRP3 in vitro using primary alveolar macrophages (AM) or THP-1 cells with ..
  23. MECHANISM OF UREASE METALLOCENTER BIOSYNTHESIS
    Robert P Hausinger; Fiscal Year: 2010
    ..The urease apoprotein (UreABC) serves as the scaffold for creation of a novel lysine carbamate-bridged, dinuclear nickel active site metallocenter...
  24. Complex Metallocluster Structure and Assembly
    Catherine L Drennan; Fiscal Year: 2012
    ..This proposal focuses on nickel and iron-sulfur containing proteins and their metallochaperones, as well as the regulation of nickel uptake and ..
  25. Development of Carbamate Amination Methodology and Synthesis of Levofloxacin
    NOAH FREDERICK FINE NATHEL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The specific aim for this proposal describes the development and utility of nickel-catalyzed aminations of aryl carbamates...
  26. Male Subfertility By Ni2+ Poisoning of Ca2+ Channels ?
    Susan Benoff; Fiscal Year: 2001
    b>Nickel is widely used in steel alloys and as metal plate. Nickel salts are well-recognized as allergens and carcinogens...
  27. IN VITRO INVESTIGATION OF SLIDING MECHANICS
    Robert Kusy; Fiscal Year: 2002
    ..materials (titanium brackets and composite archwires) and conventional orthodontic materials (stainless steel, nickel-titanium, beta-titanium, polycrystalline alumina, and single crystal sapphire) will be measured...
  28. Synthesis of CO Dehydrogenase Model Complexes for Catalytic Reductions of CO2
    DAVID CHARLES LACY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The nickel enzyme CODH (carbon monoxide dehydrogenase) plays a critical role in carbon cycling via microbial metabolism that converts CO2 to cellular carbon and, as such, is essential to life on this ..
  29. Transition Metal-Catalyzed Chemistry in Water at Room Temperature
    Bruce H Lipshutz; Fiscal Year: 2013
    ..The first cases of couplings using nickel catalysis will also be further investigated in reactions of alkenyl halides with in situ-generated organozinc ..
  30. Vaccinia Proteome Affinity Reagents From Phage Display
    Philip Felgner; Fiscal Year: 2005
    ..The individual proteins will be coated onto separate wells of either nickel, or anti-HA coated 96-well plates, and the plates will be used to scan the phage display libraries for high ..
  31. MECHANISM OF METAL ANTAGONISTIC EFFECT ON BPDE MUTANTS
    DAVID REINHOLD; Fiscal Year: 1999
    ..This proposal will specifically examine the interaction of metals (chromium and nickel) and benz[a]alpyrene diol epoxide (BPDE), all common environmental carcinogens, on the mutant frequency of the ..
  32. Molecular Mechanisms of Nickel-induced Tumorigenicity.
    Chuanshu Huang; Fiscal Year: 2013
    ..by applicant): This competitive renewal application will continue examining the molecular mechanisms by which nickel compounds mediate lung carcinogenesis...
  33. FLUORESCENT AND LARGE METAL CLUSTER COMBINATION PROBES
    Richard Powell; Fiscal Year: 1999
    ..attempts to develop fluorescent gold particles; 3) fluorescent Nanogold and larger clusters that incorporate nickel (II) chelate that binds polyhistidine sequences engineered into His- tagged recombinant protein expressed in cells;..
  34. METAL CARCINOGEN-INDUCED MUTATIONS IN MAMMALIAN GENES
    EDWIN MURPHY; Fiscal Year: 1992
    ..g., compounds of nickel, chromium and cadmium) known to induce respiratory and bladder cancers as well as birth defects...
  35. FUNCTIONAL ANALYSIS OF A LEAD/CADMIUM/ZINC ATPASE
    Bharati Mitra; Fiscal Year: 2010
    ..These pumps maintain homeostasis of essential trace metals like copper, zinc, cobalt and nickel, and mediate resistance to toxic metals such as lead, cadmium and silver...
  36. Nickel Metabolism in Helicobacter pylori
    Robert Maier; Fiscal Year: 2006
    ..Two nickel-containing enzymes, urease and hydrogenase, are important for the bacterium's mucosal-colonizing abilities...
  37. RAPID KINETIC AND OTHER STUDIES OF BIOLOGICAL OXYGENASES
    David Ballou; Fiscal Year: 2002
    ..This system consists of a series of enzymes with cobalamin, nickel, and iron-sulfur centers...
  38. Electrophilic Boranes: Directed Hydroboration, Borylation, and Related Reactions
    Edwin Vedejs; Fiscal Year: 2012
    ..In particular, palladium or nickel catalyzed Suzuki-Miyaura coupling of boronic acids is revolutionizing the way that experimental drugs are made due ..
  39. Investigating Health Effects From Exposure to Organic Carbon and Nickel Aerosol
    Richard E Peltier; Fiscal Year: 2010
    ..and developing a better understanding of the health implications associated with exposure to fine particle nickel. Dr...
  40. REGULATORY MECHANISMS IN THE IMMUNE SYSTEM
    John Kappler; Fiscal Year: 2007
    T cell mediated metal hypersensitivity is wide spread in the human population. Two examples are hypersensitivity to nickel (Ni) often associated with exposure to Ni contained jewelry and to beryllium (Be) a common problem in the ..
  41. Catalytic hydroacylation: Transforming C-H bonds into biorelevant esters and keto
    VY M DONG; Fiscal Year: 2013
    ..will provide fundamental insights into the use of various catalysts, including rhodium, ruthenium, cobalt, and nickel, for the activation and functionalization of carbon-hydrogen bonds-a long standing challenge in modern organic ..
  42. Palladium and Nickel Catalyzed C-H Activation/C-C Bond Formation
    Dipannita Kalyani; Fiscal Year: 2013
    ..Specifically this proposal seeks to develop palladium- and nickel-catalyzed methods for the construction of C-C bonds...
  43. Mechanism of ambient particulate matter assosicated cardiovascular diseases: a fe
    Qingshan Qu; Fiscal Year: 2010
    ..5 contained elevated concentrations of nickel (Ni) as compared to days with typically lower Ni exposure...
  44. Interstitial Cystitis Clinical Research Network (ICCRN)
    J Nickel; Fiscal Year: 2007
    ..J. Curtis Nickel in Kingston, Canada and recently expanded to take part in the NIH ICCTG RCT #2...
  45. REACTIVITY OF NICKEL COMPLEXES WITH DNA
    CYNTHIA BURROWS; Fiscal Year: 1999
    DESCRIPTION: Human exposure to toxic metals including nickel and toxic oxides including SO(x) and NO(x) results in damage to genetic material...
  46. PHYSIOLOGY OF BACTERIAL NICKEL METABOLISM
    Robert Maier; Fiscal Year: 1991
    b>Nickel is an essential element for growth of many microorganisms, as this element is a component of enzymes involved in ureolysis, H2 metabolism, methane production and carbon monoxide utilization...
  47. CARCINOGENESIS TESTING OF SINTERED POROUS COCRMP IMPLANT
    BENDICHT PAULI; Fiscal Year: 1991
    ..Our preliminary studies suggested that the risk of such tumor development might be attributed to (1) high nickel, cobalt, or chromium contents in the implants; and (2) large implant surface areas, typical of cementless porous ..
  48. GENOMIC SCALE CLONING OF NUCLEAR DNA BINDING PROTEINS
    Peter Tolias; Fiscal Year: 1999
    ..encoded by some of these cDNAs will localize to the nucleus where they can be purified from a nuclear extract with nickel-agarose beads through their His-tagged C-terminus...
  49. Micromachined Fluid Transfer Devices for Molecular Screening
    ROBERT HAUSHALTER; Fiscal Year: 2006
    ..FTD in a micromolding process: the silicon FTDs are used to prepare a positive silicon master mold onto which a nickel-cobalt alloy is electrodeposited (i.e...
  50. FERROMAGNETIC HYPERTHERMIA & IODINE-125 BRACHYTHERAPY
    Richard Steeves; Fiscal Year: 1992
    ..Another advantage unique to ferromagnetic hyperthermia is that the nickel and copper alloy converts energy from a surrounding EM field into heat energy, but only up to a preset level (e.g...
  51. MECHANISMS OF CYTOSKELETAL INJURY BY NI COMPOUNDS
    Ken Lin; Fiscal Year: 1990
    b>Nickel (Ni), a widely used metal in a variety of industries, is a well documented carcinogen as well as a potent skin sensitizer causing severe allergic contact dermatitis...
  52. Power Source For Mobility Aids
    Robert Dean; Fiscal Year: 2004
    ..Today the best (and most expensive) rechargeable batteries (nickel metal hydride) store only 0.25 MJ/kg (70 W-hrs/kg) and the technology is static...
  53. Hypoxia Signaling, Chromatin Remodeling and Nickel Carcinogenesis
    Max Costa; Fiscal Year: 2009
    ..These studies will allow us to understand the importance of hypoxia signaling and the HIF-1alpha transcription factor in promoting neoplastic cell transformation. ..
  54. ASSESSING ROLES OF NICKEL HYDRIDES IN HYDROGENASES
    Marcetta Darensbourg; Fiscal Year: 1993
    Description: The nickel-containing hydrogenases found in a variety of methanogenic and acetogenic bacteria have been shown to be characterized by electron-rich iron sulfur clusters, (i.e...
  55. STUDIES OF SYNTHETIC METALLOENZYME MIMICS
    CYNTHIA BURROWS; Fiscal Year: 1991
    ..New macrocyclic nickel complexes will also be studied which bear polyammonium side chains derived from spermine...
  56. DNA Damage and Tobacco-Induced Lung Cancer
    ERIC MOON SHONG TANG; Fiscal Year: 2009
    ..We recently found that nickel, chromium, and lipid peroxidation metabolites can greatly reduce cellular DNA repair capacity...
  57. STRUCTURAL MODELS FOR NICKEL ENZYMES
    WALTER CLELAND; Fiscal Year: 1991
    b>Nickel is an essential trace element which is found in enzymes involved in the metabolism of hydrogen, carbon monoxide and urea as well as the synthesis of acetyl coenzyme A and methane. Exposure to excess nickel has been linked to cancer...
  58. Chronic Prostatitis Collaborative Research Network CPCRN
    J Nickel; Fiscal Year: 2007
    ..The Queen's University Prostatitis Research Group was established under the directorship of Dr. J. Curtis Nickel in Kingston, Canada approximately 10 years ago. In the last 8 years, Dr. J.C...
  59. Pediatric Thin-Film TiNi Catheter-Based Heart Valve
    Daniel Levi; Fiscal Year: 2005
    ..Nitinol (TiNi), a titanium-nickel alloy, has shape-memory and super-elastic characteristics. It is biocompatible, very strong, and resists fatigue...
  60. MECHANISMS OF METAL MUTAGENESIS: CR, NI, & BE
    Elizabeth Snow; Fiscal Year: 1991
    A number of industrially important metals and carcinogens. Nickel and chromium stand out because they are human and animal carcinogens and also positive in short-term toxicity tests...
  61. NICKEL-DEPENDENT ENZYMES IN METHANOGENESIS
    Christopher Walsh; Fiscal Year: 1991
    The objectives of this research are to elucidate the role of 8-hydroxy-7-demethyl-5-deazaflavin coenzymes and nickel-dependent enzymes in the biogenesis of natural gas from C02 and H2 by methanogenic bacteria...
  62. ACETOGENIC AUTOTROPHY AND METABOLISM OF NICKEL
    HAROLD DRAKE; Fiscal Year: 1990
    b>Nickel is a biologically active trace metal important to mammalian health, as are numerous obligately anaerobic bacteria which inhabit the microintestinal environment...
  63. NEUROTOXICITY OF METAL CHELATES
    Bernard Weiss; Fiscal Year: 1990
    ..Lead, copper, nickel, methylmercury, cadmium, and thallium are among the metals for which such effects have been shown...