molybdenum

Summary

Summary: A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.94. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase. (From Dorland, 27th ed)

Top Publications

  1. ncbi Integrated circuits based on bilayer MoS₂ transistors
    Han Wang
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
    Nano Lett 12:4674-80. 2012
  2. ncbi van der Waals epitaxy of MoS₂ layers using graphene as growth templates
    Yumeng Shi
    Department of Electrical Engineering and Computer Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Nano Lett 12:2784-91. 2012
  3. pmc Variation in molybdenum content across broadly distributed populations of Arabidopsis thaliana is controlled by a mitochondrial molybdenum transporter (MOT1)
    Ivan Baxter
    Bindley Bioscience Center, Purdue University, West Lafayette, Indiana, United States of America
    PLoS Genet 4:e1000004. 2008
  4. ncbi Biosynthesis of the iron-molybdenum cofactor of nitrogenase
    Luis M Rubio
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
    Annu Rev Microbiol 62:93-111. 2008
  5. ncbi Hexavalent molybdenum reduction to molybdenum blue by S. marcescens strain Dr. Y6
    M Y Shukor
    Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
    Appl Biochem Biotechnol 149:33-43. 2008
  6. ncbi Molybdate reduction by Pseudomonas sp. strain DRY2
    M Y Shukor
    Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia
    J Appl Microbiol 108:2050-8. 2010
  7. pmc Valley-selective circular dichroism of monolayer molybdenum disulphide
    Ting Cao
    International Center for Quantum Materials, Peking University, Beijing 100871, China
    Nat Commun 3:887. 2012
  8. ncbi Hexavalent molybdenum reduction to Mo-blue by Acinetobacter calcoaceticus
    M Y Shukor
    Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, 43400, Serdang, Selangor, Malaysia
    Folia Microbiol (Praha) 55:137-43. 2010
  9. ncbi Reduction of Mo(VI) by the bacterium Serratia sp. strain DRY5
    M F A Rahman
    Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, UPM 43400 Serdang, Selangor, Malaysia
    J Environ Biol 30:65-72. 2009
  10. ncbi Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis
    Quintin Pan
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Res 62:4854-9. 2002

Detail Information

Publications377 found, 100 shown here

  1. ncbi Integrated circuits based on bilayer MoS₂ transistors
    Han Wang
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
    Nano Lett 12:4674-80. 2012
    Two-dimensional (2D) materials, such as molybdenum disulfide (MoS(2)), have been shown to exhibit excellent electrical and optical properties...
  2. ncbi van der Waals epitaxy of MoS₂ layers using graphene as growth templates
    Yumeng Shi
    Department of Electrical Engineering and Computer Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Nano Lett 12:2784-91. 2012
    ..The synthesized two-dimensional MoS(2)/Graphene hybrids possess great potential toward the development of new optical and electronic devices as well as a wide variety of newly synthesizable compounds for catalysts...
  3. pmc Variation in molybdenum content across broadly distributed populations of Arabidopsis thaliana is controlled by a mitochondrial molybdenum transporter (MOT1)
    Ivan Baxter
    Bindley Bioscience Center, Purdue University, West Lafayette, Indiana, United States of America
    PLoS Genet 4:e1000004. 2008
    b>Molybdenum (Mo) is an essential micronutrient for plants, serving as a cofactor for enzymes involved in nitrate assimilation, sulfite detoxification, abscisic acid biosynthesis, and purine degradation...
  4. ncbi Biosynthesis of the iron-molybdenum cofactor of nitrogenase
    Luis M Rubio
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
    Annu Rev Microbiol 62:93-111. 2008
    The iron-molybdenum cofactor (FeMo-co), located at the active site of the molybdenum nitrogenase, is one of the most complex metal cofactors known to date...
  5. ncbi Hexavalent molybdenum reduction to molybdenum blue by S. marcescens strain Dr. Y6
    M Y Shukor
    Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
    Appl Biochem Biotechnol 149:33-43. 2008
    A molybdate-reducing bacterium has been locally isolated. The bacterium reduces molybdate or Mo(6+) to molybdenum blue (molybdate oxidation states of between 5+ and 6+)...
  6. ncbi Molybdate reduction by Pseudomonas sp. strain DRY2
    M Y Shukor
    Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia
    J Appl Microbiol 108:2050-8. 2010
    To isolate and characterize a potent molybdenum-reducing bacterium.
  7. pmc Valley-selective circular dichroism of monolayer molybdenum disulphide
    Ting Cao
    International Center for Quantum Materials, Peking University, Beijing 100871, China
    Nat Commun 3:887. 2012
    ..Here we show, using first principles calculations, that monolayer molybdenum disulphide is an ideal material for valleytronics, for which valley polarization is achievable via valley-..
  8. ncbi Hexavalent molybdenum reduction to Mo-blue by Acinetobacter calcoaceticus
    M Y Shukor
    Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, 43400, Serdang, Selangor, Malaysia
    Folia Microbiol (Praha) 55:137-43. 2010
    A local molybdenum-reducing bacterium was isolated and tentatively identified as Acinetobacter calcoaceticus strain Dr.Y12 based on carbon utilization profiles using Biolog GN plates and 16S rDNA comparative analysis...
  9. ncbi Reduction of Mo(VI) by the bacterium Serratia sp. strain DRY5
    M F A Rahman
    Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, UPM 43400 Serdang, Selangor, Malaysia
    J Environ Biol 30:65-72. 2009
    ..heavy metal reducers for cost effective bioremediation strategy have resulted in the isolation of a potent molybdenum-reducing bacterium. The isolate was tentatively identified as Serratia sp...
  10. ncbi Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis
    Quintin Pan
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Res 62:4854-9. 2002
    ..Our study suggests that a major mechanism of the antiangiogenic effect of copper deficiency induced by TM is suppression of NFkappaB, contributing to a global inhibition of NFkappaB-mediated transcription of proangiogenic factors...
  11. ncbi Structure of an ABC transporter in complex with its binding protein
    Kaspar Hollenstein
    Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland
    Nature 446:213-6. 2007
    ..cancer cells, bacterial ABC importers are essential for the uptake of nutrients, including rare elements such as molybdenum. A detailed understanding of their mechanisms requires direct visualization at high resolution and in distinct ..
  12. ncbi An improved enzyme assay for molybdenum-reducing activity in bacteria
    M Y Shukor
    Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    Appl Biochem Biotechnol 144:293-300. 2008
    b>Molybdenum-reducing activity in the heterotrophic bacteria is a phenomenon that has been reported for more than 100 years. In the presence of molybdenum in the growth media, bacterial colonies turn to blue...
  13. ncbi A molybdenum complex bearing PNP-type pincer ligands leads to the catalytic reduction of dinitrogen into ammonia
    Kazuya Arashiba
    Institute of Engineering Innovation, School of Engineering, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 8656, Japan
    Nat Chem 3:120-5. 2011
    ..of ammonia being produced with the catalyst (12 equiv. of ammonia are produced based on the molybdenum atom of the catalyst)...
  14. ncbi Mo (VI) reduction to molybdenum blue by Serratia marcescens strain Dr.Y9
    Shukor Mohd Yunus
    Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, UPM 43400 Serdang, Selangor, Malaysia
    Pol J Microbiol 58:141-7. 2009
    In this work we report on the isolation of a local molybdenum-reducing bacterium. The bacterium reduced molybdate or Mo(6+) to molybdenum blue (oxidation states between 5+ to 6+)...
  15. ncbi Influence of copper status on the accumulation of toxic and essential metals in cattle
    I Blanco-Penedo
    Universidade de Santiago de Compostela, Departamento de Patoloxia Animal, Facultade de Veterinaria, Lugo, Spain
    Environ Int 32:901-6. 2006
    ..Correlations between copper, toxic metals (cadmium, lead) and essential metals (molybdenum, iron, zinc, selenium, manganese and cobalt) concentrations were evaluated in liver and kidney of 195 calves ..
  16. ncbi Reduction of molybdate to molybdenum blue by Enterobacter sp. strain Dr.Y13
    M Y Shukor
    Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, UPM 43400 Serdang, Selangor, Malaysia
    J Basic Microbiol 49:S43-54. 2009
    Extensive use of metals in various industrial applications has caused substantial environmental pollution. Molybdenum-reducing bacteria isolated from soils can be used to remove molybdenum from contaminated environments...
  17. ncbi Reduction of molybdate to molybdenum blue by Klebsiella sp. strain hkeem
    H K Lim
    Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, UPM Serdang, Selangor, Malaysia
    J Basic Microbiol 52:296-305. 2012
    ..Strain hkeem produced 3 times more molybdenum blue than Serratia sp. strain Dr.Y8; the most potent Mo-reducing bacterium isolated to date...
  18. pmc The molybdenum cofactor
    Ralf R Mendel
    Department of Plant Biology, Braunschweig University of Technology, 38106 Braunschweig, Germany
    J Biol Chem 288:13165-72. 2013
    The transition element molybdenum needs to be complexed by a special cofactor to gain catalytic activity...
  19. ncbi Molybdenum enzymes, their maturation and molybdenum cofactor biosynthesis in Escherichia coli
    Chantal Iobbi-Nivol
    Institut de Microbiologie de la Mediterranee, Aix Marseille Universite, Marseille, France
    Biochim Biophys Acta 1827:1086-101. 2013
    b>Molybdenum cofactor (Moco) biosynthesis is an ancient, ubiquitous, and highly conserved pathway leading to the biochemical activation of molybdenum...
  20. ncbi Trace elements status in diabetes mellitus type 2: possible role of the interaction between molybdenum and copper in the progress of typical complications
    Crescencio Rodríguez Flores
    Department of Chemistry, University of Guanajuato, 36000 Guanajuato, Mexico
    Diabetes Res Clin Pract 91:333-41. 2011
    ..In such approach, aluminum, vanadium, chromium, manganese, cobalt, nickel, copper, zinc, arsenic, selenium, molybdenum, mercury, cadmium and lead were determined by inductively coupled plasma-mass spectrometry (ICP-MS) in serum and ..
  21. ncbi Phase II trial of copper depletion with tetrathiomolybdate as an antiangiogenesis strategy in patients with hormone-refractory prostate cancer
    N Lynn Henry
    Department of Internal Medicine, Division of Hematology, University of Michigan School of Medicine, Ann Arbor, Mich, USA
    Oncology 71:168-75. 2006
    ..In tumor models, the copper-chelating agent tetrathiomolybdate (TM) has been shown to be antiangiogenic. We evaluated the antitumor activity of TM in patients with hormone-refractory prostate cancer (HRPC)...
  22. pmc Biochemical and spectroscopic characterization of the human mitochondrial amidoxime reducing components hmARC-1 and hmARC-2 suggests the existence of a new molybdenum enzyme family in eukaryotes
    Bettina Wahl
    Department of Plant Biology, Technische Universitat Braunschweig, 38023 Braunschweig, Germany
    J Biol Chem 285:37847-59. 2010
    The mitochondrial amidoxime reducing component mARC is a newly discovered molybdenum enzyme that is presumed to form the catalytical part of a three-component enzyme system, consisting of mARC, heme/cytochrome b(5), and NADH/FAD-dependent ..
  23. ncbi Synthesis of large-area MoS2 atomic layers with chemical vapor deposition
    Yi Hsien Lee
    Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan
    Adv Mater 24:2320-5. 2012
    ..Optical, microscopic and electrical measurements suggest that the synthetic process leads to the growth of MoS(2) monolayer. The TEM images verify that the synthesized MoS(2) sheets are highly crystalline...
  24. ncbi Essential metals for nitrogen fixation in a free-living N₂-fixing bacterium: chelation, homeostasis and high use efficiency
    J P Bellenger
    Department of Geosciences, PEI, Guyot Hall, Princeton University, Princeton, NJ 08544, USA
    Environ Microbiol 13:1395-411. 2011
    ..We conclude that A. vinelandii is well adapted to fix nitrogen in metal-limited soil environments...
  25. ncbi Exposure to chromium, cobalt and molybdenum from metal-on-metal total hip replacement and hip resurfacing arthroplasty
    Wolf Christoph Witzleb
    Department of Orthopaedic Surgery, Universty Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
    Acta Orthop 77:697-705. 2006
    ..This study was designed to investigate the serum concentration profiles of chromium, cobalt and molybdenum after implantation of a Birmingham hip resurfacing arthroplasty (BHR) and a cementless total hip replacement ..
  26. pmc Molecular characterization of the gene cluster coxMSL encoding the molybdenum-containing carbon monoxide dehydrogenase of Oligotropha carboxidovorans
    U Schübel
    Lehrstuhl fur Mikrobiologie, Universitat Bayreuth, Germany
    J Bacteriol 177:2197-203. 1995
    ..Sequence analysis suggested association of molybdopterin cytosine dinucleotide and flavin adenine dinucleotide with CoxL and of the [2Fe-2S] clusters with CoxS...
  27. pmc Orphan SelD proteins and selenium-dependent molybdenum hydroxylases
    Daniel H Haft
    Department of Bioinformatics, J, Craig Venter Institute, Rockville, MD 20850, USA
    Biol Direct 3:4. 2008
    ..in selenouridine-modified tRNAs, in proteins translated with selenocysteine, and in the selenium-dependent molybdenum hydroxylases (SDMH). The first two uses both require the selenophosphate synthetase gene, selD...
  28. ncbi Catalytic reduction of dinitrogen to ammonia at a single molybdenum center
    Dmitry V Yandulov
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 301:76-8. 2003
    Dinitrogen (N2) was reduced to ammonia at room temperature and 1 atmosphere with molybdenum catalysts that contain tetradentate [HIPTN3N]3- triamidoamine ligands (such as [HIPTN3N]Mo(N2), where [HIPTN3N]3- is [(3,5-(2,4,6-i-Pr3C6H2)..
  29. ncbi Tracing the stepwise oxygenation of the Proterozoic ocean
    C Scott
    Department of Earth Sciences, University of California, Riverside, California 92521, USA
    Nature 452:456-9. 2008
    ..perspective on ocean oxygenation based on the authigenic accumulation of the redox-sensitive transition element molybdenum in sulphidic black shales...
  30. pmc Molybdoproteomes and evolution of molybdenum utilization
    Yan Zhang
    Department of Biochemistry, University of Nebraska, Lincoln, NE 68588 0664, USA
    J Mol Biol 379:881-99. 2008
    The trace element molybdenum (Mo) is utilized in many life forms, and it is a key component of several enzymes involved in nitrogen, sulfur, and carbon metabolism...
  31. pmc Metal trafficking for nitrogen fixation: NifQ donates molybdenum to NifEN/NifH for the biosynthesis of the nitrogenase FeMo-cofactor
    Jose A Hernandez
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 105:11679-84. 2008
    The molybdenum nitrogenase, present in a diverse group of bacteria and archea, is the major contributor to biological nitrogen fixation...
  32. pmc A pilot trial of the anti-angiogenic copper lowering agent tetrathiomolybdate in combination with irinotecan, 5-flurouracil, and leucovorin for metastatic colorectal cancer
    Elaina M Gartner
    Wayne State University, 4100 John R, 4HWCRC, Detroit, MI 48108, USA
    Invest New Drugs 27:159-65. 2009
    ..TM can be safely added to IFL without compromising dose intensity or diminishing the expected RR. Changes in serum VEGF, IL-8, and IL-6 after treatment may directly reflect changes in CRC tissue angiogenesis...
  33. ncbi The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs
    Sanja Gruenewald
    Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, Christian Albrechts University of Kiel, Gutenbergstrasse 76, D 24118 Kiel, Germany
    J Med Chem 51:8173-7. 2008
    ..Thus, the recombinant enzyme allows prediction about in vivo reduction of N-hydroxylated prodrugs. Furthermore, the prodrug principle is not dependent on cytochrome P450 enzymes...
  34. ncbi A late methanogen origin for molybdenum-dependent nitrogenase
    E S Boyd
    Department of Chemistry and Biochemistry and the Astrobiology Biogeocatalysis Research Center, Montana State University, Bozeman, MT, USA
    Geobiology 9:221-32. 2011
    ..2.5-2.0 Ga). It has been suggested that the iron (Fe)- or vanadium (V)-dependent nitrogenase rather than molybdenum (Mo)-dependent form was responsible for dinitrogen fixation during this time because oceans were depleted in Mo ..
  35. pmc Algae and humans share a molybdate transporter
    Manuel Tejada-Jimenez
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad de Cordoba, Campus de Rabanales, Edif Severo Ochoa, 14071 Cordoba, Spain
    Proc Natl Acad Sci U S A 108:6420-5. 2011
    Almost all living organisms need to obtain molybdenum from the external medium to achieve essential processes for life...
  36. ncbi Effects of molybdenum deficiency and defects in molybdate transporter MOT1 on transcript accumulation and nitrogen/sulphur metabolism in Arabidopsis thaliana
    Yoko Ide
    Biotechnology Research Center, University of Tokyo, 1 1 1, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Exp Bot 62:1483-97. 2011
    b>Molybdenum (Mo) is a micronutrient essential for plant growth, as several key enzymes of plant metabolic pathways contain Mo cofactor in their catalytic centres...
  37. pmc Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikis
    Pawan Kumar
    Department of Otolaryngology Head and Neck Surgery and Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
    Mol Cancer 9:206. 2010
    ..However, very little is known about the effect of TM on tumor cell function and tumor metastasis. In this study, we explored the mechanisms underlying TM-mediated inhibition of tumor metastasis...
  38. pmc Hypersensitivity of Escherichia coli Delta(uvrB-bio) mutants to 6-hydroxylaminopurine and other base analogs is due to a defect in molybdenum cofactor biosynthesis
    S G Kozmin
    Department of Genetics, Sankt Petersburg State University, Saint Petersburg, Russia
    J Bacteriol 182:3361-7. 2000
    ..The moeAB operon provides one of a large number of genes responsible for biosynthesis of the molybdenum cofactor...
  39. ncbi Reduction of N-hydroxy-sulfonamides, including N-hydroxy-valdecoxib, by the molybdenum-containing enzyme mARC
    Antje Havemeyer
    Institute of Pharmacy, Christian Albrechts University of Kiel, Kiel, Germany
    Drug Metab Dispos 38:1917-21. 2010
    ..for reduction of N-hydroxylated amidine prodrugs led to the identification of two newly discovered mammalian molybdenum-containing proteins, the mitochondrial amidoxime reducing components mARC-1 and mARC-2 (Gruenewald et al., 2008)...
  40. ncbi Ethylbenzene dehydrogenase, a novel hydrocarbon-oxidizing molybdenum/iron-sulfur/heme enzyme
    O Kniemeyer
    , Celsiusstrasse 1, 28359 Bremen, Germany
    J Biol Chem 276:21381-6. 2001
    ..It is a novel molybdenum/iron-sulfur/heme protein of 155 kDa, which consists of three subunits (96, 43, and 23 kDa) in an alphabetagamma ..
  41. pmc Copper imbalances in ruminants and humans: unexpected common ground
    Neville F Suttle
    Moredun Foundation, Penicuik, Scotland
    Adv Nutr 3:666-74. 2012
    ..b>Molybdenum-rich pastures promote thiomolybdate (TM) synthesis and formation of unabsorbable Cu-TM complexes, turning risk ..
  42. ncbi Crystal structure of the xanthine oxidase-related aldehyde oxido-reductase from D. gigas
    M J Romao
    Instituto de Tecnologia Quimica e Biologica, Oeiras, Portugal
    Science 270:1170-6. 1995
    ..Mo-co is a molybdenum molybdopterin cytosine dinucleotide...
  43. pmc Repression of the Escherichia coli modABCD (molybdate transport) operon by ModE
    A M Grunden
    Department of Microbiology and Cell Science, University of Florida, Gainesville 32611, USA
    J Bacteriol 178:735-44. 1996
    ..These results show that molybdate transport in E. coli is regulated by ModE, which acts as a repressor when bound to molybdate...
  44. ncbi The prokaryotic complex iron-sulfur molybdoenzyme family
    Richard A Rothery
    Membrane Protein Research Group, Department of Biochemistry, 474 Medical Sciences Building, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Biochim Biophys Acta 1778:1897-929. 2008
    ..We have used genome sequence data to establish that there is a bias against the presence of soluble periplasmic molybdoenzymes in bacteria lacking an outer membrane...
  45. ncbi Cell biology of molybdenum in plants and humans
    Ralf R Mendel
    Institute of Plant Biology, Braunschweig University of Technology, 1 Humboldt Street, 38106 Braunschweig, Germany
    Biochim Biophys Acta 1823:1568-79. 2012
    The transition element molybdenum (Mo) needs to be complexed by a special cofactor in order to gain catalytic activity...
  46. pmc High performance molybdenum disulfide amorphous silicon heterojunction photodetector
    Mohammad R Esmaeili-Rad
    Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, California 94720, United States
    Sci Rep 3:2345. 2013
    One important use of layered semiconductors such as molybdenum disulfide (MoS2) could be in making novel heterojunction devices leading to functionalities unachievable using conventional semiconductors...
  47. ncbi Characterisation of the molybdenum-responsive ModE regulatory protein and its binding to the promoter region of the modABCD (molybdenum transport) operon of Escherichia coli
    L A Anderson
    Department of Biochemistry, Medical Sciences Institute, University of Dundee, UK
    Eur J Biochem 246:119-26. 1997
    b>Molybdenum-dependent repression of transcription of the Escherichia coli modABCD operon, which encodes the high-affinity molybdate transporter, is mediated by the ModE protein...
  48. ncbi Ambipolar MoS2 thin flake transistors
    Yijin Zhang
    Quantum Phase Electronics Center and Department of Applied Physics, The University of Tokyo, 7 3 1 Hongo, Tokyo 113 8656, Japan
    Nano Lett 12:1136-40. 2012
    ....
  49. ncbi Two crystal structures of the cytoplasmic molybdate-binding protein ModG suggest a novel cooperative binding mechanism and provide insights into ligand-binding specificity
    L Delarbre
    Department of Biological Chemistry, Norwich, NR4 7UH, UK
    J Mol Biol 308:1063-79. 2001
    ..two small beta-barrel domains, which display an OB-fold motif, also seen in the related structure of ModE, a molybdenum-dependent transcriptional regulator, and very recently in the Mop protein that, like ModG, has been implicated ..
  50. ncbi Highly efficient electrocatalytic hydrogen production by MoS(x) grown on graphene-protected 3D Ni foams
    Yung Huang Chang
    Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan, ROC
    Adv Mater 25:756-60. 2013
    ..The superior performance of hydrogen evolution is attributed to the relatively high catalyst loading weight as well as its relatively low resistance...
  51. pmc Influence of sulfur deficiency on the expression of specific sulfate transporters and the distribution of sulfur, selenium, and molybdenum in wheat
    Fumie Shinmachi
    Rothamsted Research, West Common, Harpenden, Hertfordshire AL52JQ, United Kingdom
    Plant Physiol 153:327-36. 2010
    ..In 2008, S, sulfate, selenium (Se), and molybdenum (Mo) concentrations and sulfate transporter gene expression were analyzed throughout development...
  52. ncbi The involvement of molybdenum in life
    R J P Williams
    Inorganic Chemistry Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QR, United Kingdom
    Biochem Biophys Res Commun 292:293-9. 2002
    Quite extraordinarily molybdenum is an essential element in life for the uptake of nitrogen from both nitrogen gas and nitrate, yet it is a relatively rare heavy trace element...
  53. pmc Molybdenum and phosphorus interact to constrain asymbiotic nitrogen fixation in tropical forests
    Nina Wurzburger
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS ONE 7:e33710. 2012
    ..Phosphorus (P) is thought to limit N(2) fixation in many tropical soils, yet both molybdenum (Mo) and P are crucial for the nitrogenase reaction (which catalyzes N(2) conversion to ammonia) and cell growth...
  54. ncbi Periplasmic nitrate reductase revisited: a sulfur atom completes the sixth coordination of the catalytic molybdenum
    Shabir Najmudin
    Departamento de Quimica, FCT UNL, REQUIMTE CQFB, Monte de Caparica, 2829 516, Almada, Portugal
    J Biol Inorg Chem 13:737-53. 2008
    ..electron paramagnetic resonance (EPR) studies in both catalytic and inhibiting conditions showed that the molybdenum center has high coordination flexibility when reacted with reducing agents, substrates or inhibitors...
  55. ncbi Global gene expression analysis revealed an unsuspected deo operon under the control of molybdate sensor, ModE protein, in Escherichia coli
    Han Tao
    Department of Microbiology and Cell Science, University of Florida, Box 110700, Gainesville, FL 32611, USA
    Arch Microbiol 184:225-33. 2005
    ..This study identified additional targets, such as deo and opp, for the Mo-dependent control in E. coli...
  56. ncbi Molybdate transport and its effect on nitrogen utilization in the cyanobacterium Anabaena variabilis ATCC 29413
    Marta Zahalak
    Department of Biology, University of Missouri St Louis, 8001 Natural Bridge Road, St Louis, MO 63121 4499, USA
    Mol Microbiol 51:539-49. 2004
    b>Molybdenum is an essential component of the cofactors of many metalloenzymes including nitrate reductase and Mo-nitrogenase...
  57. ncbi Maternal-foetal status of copper, iron, molybdenum, selenium and zinc in obese gestational diabetic pregnancies
    E Al-Saleh
    Department of Obstetrics and Gynecology Faculty of Medicine, University of Kuwait, P O Box 24923, Safat, 13110, Kuwait
    Acta Diabetol 44:106-13. 2007
    ..We conclude that obesity is not associated with significant alterations in antioxidant enzyme status in gestational diabetes and only with relatively minor alterations in status of some essential trace elements...
  58. pmc Nitrogenase phylogeny and the molybdenum dependence of nitrogen fixation in Methanococcus maripaludis
    P S Kessler
    Department of Microbiology, University of Washington, Seattle 98195, USA
    J Bacteriol 179:541-3. 1997
    We studied the effects of molybdenum, vanadium, and tungsten on the diazotrophic growth of Methanococcus maripaludis. Mo stimulated growth, with a maximal response at 4.0 microM, while V had no effect at any concentration tested...
  59. pmc The molybdate-responsive Escherichia coli ModE transcriptional regulator coordinates periplasmic nitrate reductase (napFDAGHBC) operon expression with nitrate and molybdate availability
    Paul M McNicholas
    Department of Microbiology, University of California, Los Angeles, Los Angeles, California 90095 1489, USA
    J Bacteriol 184:3253-9. 2002
    ..The upstream ModE regulatory site functions to override nitrate control of napF gene expression when the essential enzyme component, molybdate, is limiting in the cell environment...
  60. ncbi Active site geometry and substrate recognition of the molybdenum hydroxylase quinoline 2-oxidoreductase
    Irena Bonin
    Abteilung für Strukturforschung, Max Planck Institut fur Biochemie, 82152 Martinsried, Germany
    Structure 12:1425-35. 2004
    ..Qor is a member of the molybdenum hydroxylases...
  61. ncbi Molybdenum and tungsten enzymes: the xanthine oxidase family
    Carlos D Brondino
    Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Campus Universitario, 3000 Santa Fe, Argentina
    Curr Opin Chem Biol 10:109-14. 2006
    Mononuclear molybdenum and tungsten are found in the active site of a diverse group of enzymes that, in general, catalyze oxygen atom transfer reactions...
  62. pmc Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator
    Seiko Ishida
    Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA
    Cancer Cell 17:574-83. 2010
    ..Our results identify the copper transporter as a therapeutic target, which can be manipulated with copper chelating drugs to selectively enhance the benefits of platinum-containing chemotherapeutic agents...
  63. ncbi Molybdenum-containing hydroxylases
    Russ Hille
    Department of Molecular and Cellular Biochemistry, The Ohio State University, 333 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210, USA
    Arch Biochem Biophys 433:107-16. 2005
    Unlike monooxygenases, molybdenum-containing hydroxylases catalyze the hydroxylation of carbon centers using oxygen derived ultimately from water, rather than O(2), as the source of the oxygen atom incorporated into the product, and do ..
  64. ncbi The role of copper in tumour angiogenesis
    Sarah A Lowndes
    Cancer Research UK Medical Oncology Unit, The Churchill Hospital, Oxford OX3 7LJ, UK
    J Mammary Gland Biol Neoplasia 10:299-310. 2005
    ....
  65. ncbi Molybdenum and tungsten in Campylobacter jejuni: their physiological role and identification of separate transporters regulated by a single ModE-like protein
    Michael E Taveirne
    Department of Microbiology, North Carolina State University, Raleigh, NC 27695, USA
    Mol Microbiol 74:758-71. 2009
    ..contains at least four enzymes predicted to contain a metal binding pterin (MPT), with the metal being either molybdenum or tungsten...
  66. ncbi Molybdate transport
    W T Self
    NHLBI, NIH, Bethesda, MD 20892, USA
    Res Microbiol 152:311-21. 2001
    ..Comparative analysis of the molybdate transport proteins in various bacteria and archaea is the focus of this review...
  67. ncbi Evidence for nifU and nifS participation in the biosynthesis of the iron-molybdenum cofactor of nitrogenase
    Dehua Zhao
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
    J Biol Chem 282:37016-25. 2007
    ..Although NifH contains a [4Fe-4S] cluster, the NifDK component carries two complex metalloclusters, the iron-molybdenum cofactor (FeMo-co) and the [8Fe-7S] P-cluster...
  68. pmc A mutation in the gene for the neurotransmitter receptor-clustering protein gephyrin causes a novel form of molybdenum cofactor deficiency
    J Reiss
    Institut für Medizinische Physik und Biophysik der Universität Münster, D 48149 Munster, Germany
    Am J Hum Genet 68:208-13. 2001
    ..comparison revealed homologies between gephyrin and proteins necessary for the biosynthesis of the universal molybdenum cofactor (MoCo)...
  69. ncbi Transport of molybdate in the cyanobacterium Anabaena variabilis ATCC 29413
    Teresa Thiel
    Department of Biology, University of Missouri St Louis, St Louis MO 63121, USA
    Arch Microbiol 179:50-6. 2002
    Heterocyst-forming filamentous cyanobacteria, such as Anabaena variabilis ATCC 29413, require molybdenum as a component of two essential cofactors for the enzymes nitrate reductase and nitrogenase. A...
  70. ncbi Identification of an Arabidopsis solute carrier critical for intracellular transport and inter-organ allocation of molybdate
    A Gasber
    Plant Physiology, Technical University of Kaiserslautern, Kaiserslautern, Germany
    Plant Biol (Stuttg) 13:710-8. 2011
    Plants represent an important source of molybdenum in the human diet. Recently, MOT1 has been identified as a transport protein responsible for molybdate import in Arabidopsis thaliana L...
  71. ncbi A new type of metalloprotein: The Mo storage protein from azotobacter vinelandii contains a polynuclear molybdenum-oxide cluster
    Dirk Fenske
    Lehrstuhl fur Anorganische Chemie I, Universitat Bielefeld, Universitatsstrasse 25, 33615 Bielefeld, Germany
    Chembiochem 6:405-13. 2005
    ..The Mo storage protein is constitutively synthesized with respect to the nitrogen source and is regulated by molybdenum at an extremely low concentration level (0-50 nM)...
  72. pmc A structure-based catalytic mechanism for the xanthine oxidase family of molybdenum enzymes
    R Huber
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Proc Natl Acad Sci U S A 93:8846-51. 1996
    The crystal structure of the xanthine oxidase-related molybdenum-iron protein aldehyde oxido-reductase from the sulfate reducing anaerobic Gram-negative bacterium Desulfovibrio gigas (Mop) was analyzed in its desulfo-, sulfo-, oxidized, ..
  73. ncbi A simplified method for inorganic phosphate determination and its application for phosphate analysis in enzyme assays
    Subhash D Katewa
    Department of Biochemistry, Faculty of Science, MS University of Baroda, Vadodara 390 002, India
    Anal Biochem 323:180-7. 2003
    ..hydrazine sulfate and ascorbic acid was used as the reducing agent and the conditions for the development of the molybdenum blue color were optimized. Thus in the 4.0 ml assay system, 0...
  74. ncbi NarJ is a specific chaperone required for molybdenum cofactor assembly in nitrate reductase A of Escherichia coli
    F Blasco
    Laboratoire de Chimie Bacterienne, IBSM, CNRS, Marseilles, France
    Mol Microbiol 28:435-47. 1998
    ..Fluorescence, electron paramagnetic resonance (EPR) spectroscopy and molybdenum quantification based on inductively coupled plasma emission spectroscopy (ICPES) clearly indicate that, in the ..
  75. ncbi Nickel and molybdenum contact allergies in patients with coronary in-stent restenosis
    R Koster
    Department of Cardiology, University Hospital Eppendorf, Medical Clinic, Hamburg, Germany
    Lancet 356:1895-7. 2000
    Coronary in-stent restenosis might be triggered by contact allergy to nickel, chromate, or molybdenum ions released from stainless-steel stents...
  76. ncbi Cobalt-chromium-molybdenum alloy causes metal accumulation and metallothionein up-regulation in rat liver and kidney
    Stig S Jakobsen
    Department of Neurobiology, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
    Basic Clin Pharmacol Toxicol 101:441-6. 2007
    Cobalt-chromium-molybdenum (CoCrMo) metal-on-metal hip prosthesis has had a revival due to their excellent wear properties...
  77. ncbi The formylmethanofuran dehydrogenase isoenzymes in Methanobacterium wolfei and Methanobacterium thermoautotrophicum: induction of the molybdenum isoenzyme by molybdate and constitutive synthesis of the tungsten isoenzyme
    A Hochheimer
    Max Planck Institut fur terrestrische Mikrobiologie, Fachbereich Biologie, Philipps Universitat, Marburg, Germany
    Arch Microbiol 170:389-93. 1998
    ..thermoautotrophicum have been shown to contain two isoenzymes, a tungsten-containing isoenzyme (Fwd) and a molybdenum-containing isoenzyme (Fmd)...
  78. ncbi Nitrogen and molybdenum control of nitrogen fixation in the phototrophic bacterium Rhodobacter capsulatus
    Bernd Masepohl
    Lehrstuhl für Biologie der Mikroorganismen, Fakultät für Biologie und Biotechnologie, Ruhr Universitat Bochum, 44780, Bochum, Germany
    Adv Exp Med Biol 675:49-70. 2010
    ..has overlapping transcriptional control mechanisms with regard to the presence of fixed nitrogen, oxygen, and molybdenum as well as the capability for the post-translational control of both nitrogenases in response to ammonium. R...
  79. ncbi Molecular design of yeast cell surface for adsorption and recovery of molybdenum, one of rare metals
    Takashi Nishitani
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake cho, Sakyo ku, Kyoto, 606 8502, Japan
    Appl Microbiol Biotechnol 86:641-8. 2010
    In modern industrial society, molybdenum is one of the important metals for development of the industry of rare metals...
  80. ncbi Solid-state synthesis of molybdenum and tungsten porphyrins and aerial oxidation of coordinated benzenethiolate to benzenesulfonate
    Goutam Nandi
    Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India
    Inorg Chem 51:6412-20. 2012
    A new route is developed for the synthesis of molybdenum and tungsten porphyrins using [M(NO)(2)py(2)Cl(2)] (M = Mo, W) as the metal source and TPP (dianion of 5,10,15,20-meso-tetraphenylporphyrin) in the benzoic acid melt...
  81. pmc Recent developments in the homogeneous reduction of dinitrogen by molybdenum and iron
    K Cory Macleod
    Department of Chemistry, University of Rochester, Rochester, New York 14627, USA
    Nat Chem 5:559-65. 2013
    ..The iron-molybdenum active site of the enzyme nitrogenase has inspired chemists to explore iron and molybdenum complexes in ..
  82. ncbi Biology of the molybdenum cofactor
    Ralf R Mendel
    Institute of Plant Biology, Technical University of Braunschweig, 38106 Braunschweig, Germany
    J Exp Bot 58:2289-96. 2007
    The transition element molybdenum (Mo) is an essential micronutrient for plants where it is needed as a catalytically active metal during enzyme catalysis...
  83. ncbi The Aspergillus nidulans cnxABC locus is a single gene encoding two catalytic domains required for synthesis of precursor Z, an intermediate in molybdenum cofactor biosynthesis
    S E Unkles
    School of Environmental and Evolutionary Biology, University of St Andrews, St Andrews, Fife KY16 9TH, United Kingdom
    J Biol Chem 272:28381-90. 1997
    ....
  84. ncbi Development of an inhibitive enzyme assay for copper
    M Y Shukor
    Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia
    J Environ Biol 30:39-44. 2009
    In this work the development of an inhibitive assay for copper using the molybdenum-reducing enzyme assay is presented. The enzyme is assayed using 12-molybdophosphoric acid at pH 5...
  85. ncbi Quantum chemical modeling of CO oxidation by the active site of molybdenum CO dehydrogenase
    Per E M Siegbahn
    Department of Physics, Stockholm Centre for Physics, Astronomy and Biotechnology SC FAB, Stockholm University, S 106 91 Stockholm, Sweden
    J Comput Chem 26:888-98. 2005
    The catalytic mechanism of molybdenum containing CO dehydrogenase has been studied using hybrid DFT methods with quite large chemical models...
  86. ncbi Thermal and mechanical characteristics of stainless steel, titanium-molybdenum, and nickel-titanium archwires
    Robert P Kusy
    Department of Orthodontics and Dental Research Center, School of Dentistry, University of North Carolina, Chapel Hill 27599 7455, USA
    Am J Orthod Dentofacial Orthop 131:229-37. 2007
    ..Before the practitioner can fully utilize these products, the effect of those transitions within the clinical application must be understood...
  87. ncbi Molybdenum enzymes and molybdenum cofactor in mycobacteria
    Tingyu Shi
    Institute of Modern Biopharmaceuticals, School of Life Sciences, Southwest University, Chongqing, China
    J Cell Biochem 112:2721-8. 2011
    ..It is very successful in escaping the killing mechanisms of macrophage. Molybdenum (Mo) enzymes involve in the global carbon, sulfur, and nitrogen cycles by catalyzing important redox reactions...
  88. ncbi Tetrathiomolybdate protects against cardiac damage by doxorubicin in mice
    Guoqing Hou
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, 48109, USA
    J Lab Clin Med 146:299-303. 2005
    ..Our working hypothesis, based on the inhibition of interleukin-2 by tetrathiomolybdate as shown here, is that tetrathiomolybdate interrupts the inflammatory cascade at the activated-T-lymphocyte stage...
  89. pmc The Drosophila molybdenum cofactor gene cinnamon is homologous to three Escherichia coli cofactor proteins and to the rat protein gephyrin
    K P Kamdar
    Department of Biology, Emory University, Atlanta, Georgia 30322
    Genetics 137:791-801. 1994
    Essentially all organisms depend upon molybdenum oxidoreductases which require a molybdopterin cofactor for catalytic activity...
  90. ncbi Interplay between size and crystal structure of molybdenum dioxide nanoparticles--synthesis, growth mechanism, and electrochemical performance
    Dorota Koziej
    Harvard University, School of Engineering and Applied Science, 29 Oxford Street, Cambridge, MA 02138, USA
    Small 7:377-87. 2011
    ..Is it shown that electrodes for lithium-ion batteries based on MoO(2) nanorods have a long-term cycling life. The specific discharge capacity even after 200 cycles at a discharge rate of 1 C is about 300 Ah kg(-1) ...
  91. pmc Biomimetic chemistry of iron, nickel, molybdenum, and tungsten in sulfur-ligated protein sites
    Stanislav Groysman
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Biochemistry 48:2310-20. 2009
    ..This account describes the current status of the synthetic analogue approach as applied to the mononuclear sites in certain molybdoenzymes and the polynuclear sites in hydrogenases, nitrogenase, and carbon monoxide dehydrogenases...
  92. pmc Molybdenum nitrogenase catalyzes the reduction and coupling of CO to form hydrocarbons
    Zhi Yong Yang
    Department of Chemistry and Biochemistry, Utah State University, Logan, Utah 84322, USA
    J Biol Chem 286:19417-21. 2011
    The molybdenum-dependent nitrogenase catalyzes the multi-electron reduction of protons and N(2) to yield H(2) and 2NH(3). It also catalyzes the reduction of a number of non-physiological doubly and triply bonded small molecules (e.g...
  93. pmc Copper chelation represses the vascular response to injury
    Lazar Mandinov
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough 04074, USA
    Proc Natl Acad Sci U S A 100:6700-5. 2003
    ....
  94. ncbi Breakdown of high-performance monolayer MoS2 transistors
    Dominik Lembke
    Electrical Engineering Institute, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    ACS Nano 6:10070-5. 2012
    Two-dimensional (2D) materials such as monolayer molybdenum disulfide (MoS(2)) are extremely interesting for integration in nanoelectronic devices where they represent the ultimate limit of miniaturization in the vertical direction...
  95. pmc Extending the carbon chain: hydrocarbon formation catalyzed by vanadium/molybdenum nitrogenases
    Yilin Hu
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Science 333:753-5. 2011
    ..Additionally, we show that the more common molybdenum-dependent nitrogenase can generate the same hydrocarbons from CO, although CH(4) was not detected...
  96. ncbi Direct analysis of molybdenum target generated x-ray spectra with a portable device
    S Stumbo
    Struttura Dipartimentale di Matematica e Fisica dell Università di Sassari, Sezione INEN di Cagliari, Italy
    Med Phys 31:2763-70. 2004
    ..The energy resolution has been determined using a calibrated x-ray source. Spectra were validated by comparison of the HVL measured using an ionization chamber...
  97. ncbi Plasma molybdenum reflects dietary molybdenum intake
    Judith R Turnlund
    USDA ARS, Western Human Nutrition Research Center, University of California, Davis, CA 95616, USA
    J Nutr Biochem 15:90-5. 2004
    The relationship between plasma molybdenum (Mo) and dietary intake has not been investigated in humans. We developed an isotope dilution method to determine molybdenum in 0...
  98. ncbi A whiff of oxygen before the great oxidation event?
    Ariel D Anbar
    School of Earth and Space Exploration, Arizona State University, Tempe, AZ 85287, USA
    Science 317:1903-6. 2007
    High-resolution chemostratigraphy reveals an episode of enrichment of the redox-sensitive transition metals molybdenum and rhenium in the late Archean Mount McRae Shale in Western Australia...
  99. ncbi Novel bacterial molybdenum and tungsten enzymes: three-dimensional structure, spectroscopy, and reaction mechanism
    Matthias Boll
    Institut fur Biologie II, Universitat Freiburg, Schänzlestr 1, D 79104 Freiburg, Germany
    Biol Chem 386:999-1006. 2005
    The molybdenum enzymes 4-hydroxybenzoyl-CoA reductase and pyrogallol-phloroglucinol transhydroxylase and the tungsten enzyme acetylene hydratase catalyze reductive dehydroxylation reactions, i.e...
  100. pmc Molybdenum sequestration in Brassica species. A role for anthocyanins?
    K L Hale
    Department of Biology, Anatomy Zoology Building, Colorado State University, Fort Collins, Colorado 80523, USA
    Plant Physiol 126:1391-402. 2001
    To elucidate plant mechanisms involved in molybdenum (Mo) sequestration and tolerance, Brassica spp. seedlings were supplied with molybdate, and the effects on plant physiology, morphology, and biochemistry were analyzed...
  101. ncbi Control of valley polarization in monolayer MoS2 by optical helicity
    Kin Fai Mak
    Department of Physics, Columbia University, 538 West 120th Street, New York, New York 10027, USA
    Nat Nanotechnol 7:494-8. 2012
    ..Our results, and similar results by Zeng et al., demonstrate the viability of optical valley control and suggest the possibility of valley-based electronic and optoelectronic applications in MoS(2) monolayers...

Research Grants63

  1. Expanded Testing Methods for Elements and Metals in Animal Diagnostic Specimens
    Timothy Baszler; Fiscal Year: 2013
    ..feed recalls by FDA from 2009-2012 have included 10 contamination events from zinc, potassium, copper, and molybdenum. Lastly, rare earth 11 elements have proved useful for tracing suspicious shipments of food/feed back to ..
  2. Catalytic Approach to Treatment of Cyanide Poisoning
    SIGRIDUR G SUMAN; Fiscal Year: 2010
    ..The specific aims for this work are to (1) develop molybdenum-sulfur compounds to catalytically serve as sulfane sulfur transfer agents;(2) develop a non-toxic cysteine-..
  3. Environmental exposure to metal mixtures and kidney disease
    Mary Fox; Fiscal Year: 2009
    ..The metals are barium, cadmium, cobalt, lead, mercury, molybdenum, and uranium...
  4. BIOLOGICALLY RELATED IRON-SULFUR CHEMISTRY
    RICHARD HADLEY HOLM; Fiscal Year: 2011
    ..directed at a detailed understanding of biologically relevant cluster clusters containing iron, sulfur, and molybdenum, vanadium, or nickel, various types of which are found at all levels of life...
  5. Natural Substance Derivative DHNB is A Novel Xanthine Oxidase Inhibitor
    Changyi Chen; Fiscal Year: 2013
    ..the potential toxicity of DHNB in mice;and determine whether DHNB interacts with the FAD cofactor and/or molybdenum cofactor of XO...
  6. Low-Coordinate Synthetic Models for Nitrogenase Activity
    Patrick L Holland; Fiscal Year: 2013
    ..Recent spectroscopic work on iron- molybdenum nitrogenase strongly suggests that the mechanism involves binding of N2 to iron, and involves iron-hydride ..
  7. SPECTROSCOPIC STUDIES OF MOLYBDOENZYMES AND MODELS
    Martin L Kirk; Fiscal Year: 2013
    ..by applicant): There exists a fundamental gap in our understanding of the relationship between pyranopterin molybdenum enzyme structure and function...
  8. Models for nitrate reductases and related enzymes
    Partha Basu; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The pterin-containing molybdenum cofactor (Moco) is a remarkable metal center that lies at the catalytic heart of a variety of enzymes...
  9. Acquisition of a modern continuous wave EPR spectrometer equipped with an ENDOR s
    ANDREI ASTACHKINE; Fiscal Year: 2010
    ..biochemical/biomedical projects described in this proposal include: (1) Using EPR and CW ENDOR to study the molybdenum catalytic center of sulfite-oxidizing enzymes and model synthetic Mo(V) complexes by Dr. J.H. Enemark...
  10. Polynuclear iron complexes as functional mimics of the nitrogenase FeMo-cofactor
    Theodore A Betley; Fiscal Year: 2013
    ..Dinitrogen reduction occurs at polynuclear metalloenzymes called nitrogenase. The reaction center of the Molybdenum-containing enzyme consists of a cysteine ligated MoFe7S7 cofactor (FeMoco) where dinitrogen fixation takes place...
  11. MOFE PROTEIN PROSTHETIC GROUPS IN NITROGENASE CATALYSIS
    WILLIAM NEWTON; Fiscal Year: 2003
    ..The proposed research centers on the molybdenum-iron protein of nitrogenase...
  12. Functional LnFe-NxHy Models of Biological N2 Fixation
    Jonas C Peters; Fiscal Year: 2013
    ..Our experimental approach stresses functionally, rather than structurally, faithful models of the iron-molybdenum cofactor (FeMoco)...
  13. Catalytic Stereoselective Olefin Metathesis Reactions
    Richard R Schrock; Fiscal Year: 2013
    ..Research in this program is focused on the design, synthesis and development of a range of molybdenum- and tungsten-based catalysts that can be used for one of the most powerful and efficient methods for olefin ..
  14. ASSEMBLY OF A MEMBRANE-BOUND MULTI-ENZYME COMPLEX
    JOHN DE MOSS; Fiscal Year: 1993
    ..Membrane-bound nitrate reductase is composed of three subunits (alpha, beta, gamma), a molybdenum-pterium cofactor, nonheme ion and a cytochrome b component...
  15. STRUCTURAL STUDIES ON EUKARYOTIC MOCO CONTAINING ENZYMES
    Caroline Kisker; Fiscal Year: 2003
    Enzymes containing the molybdenum cofactor catalyze important reactions in the global sulfur, nitrogen and carbon cycles and are currently classified into four different families...
  16. The Role of MgATP in Nitrogenase Catalysis
    John Peters; Fiscal Year: 2007
    ..During nitrogenase catalysis, the iron protein and molybdenum-iron protein associate and dissociate in a manner resulting in the hydrolysis of two molecules of MgATP and the ..
  17. New Olefin Metathesis Catalysts Based on Innocuous and Abundant Metals
    Yann Schrodi; Fiscal Year: 2013
    ..The overall objective of this application is to develop olefin metathesis catalysts based on low-valent molybdenum and iron metals supported by diimine and bis(imino)pyridine ligands...
  18. REDUCTION OF POLYETHYLENE WEAR IN SURGICAL IMPLANTS
    Piran Sioshansi; Fiscal Year: 1990
    The cobalt-chromium-molybdenum alloy designated standard specification F- 75 by the American Society for Testing and Materials (ASTM) is the most commonly used alloy in orthopedic prostheses for total and partial joint replacement...
  19. ENZYMES OF DINITROGEN REDUCTION
    WILLIAM ORME JOHNSON; Fiscal Year: 1991
    ..gene products which convert precursor peptides into the enzyme nitrogenase, including those which synthesize the molybdenum-iron cofactor from molybdate in the growth medium...
  20. NEW STRATEGIES FOR GLYCOCONJUGATE SYNTHESIS FROM ALKYNES
    Frank McDonald; Fiscal Year: 1999
    ..This proposal describes our continued work with molybdenum pentacarbonyl- mediated cycloisomerization reactions of alkynyl alcohols to endocyclic enol ethers (glycals) and ..
  21. IMPROVED MODEL COMPLEXES FOR MOLYBDOENZYME ACTIVE SITES
    SHARON BURGMAYER; Fiscal Year: 2000
    This project has the goal of defining the chemistry possible at the active sites of molybdenum enzymes. Every living organism relies on one or more of the approximately forty known molybdenum enzymes for sustained health...
  22. TITANIUM BASED VARIABLE MODULUS ORTHODONTIC WIRE
    LAURENCE SCHETKY; Fiscal Year: 1991
    ..Based on preliminary studies of Titanium-Molybdenum-Aluminum and Titanium-Vanadium- Aluminum alloys, it has been shown that an elastic modulus range from 2...
  23. Polynuclear Clusters in Biology - Structure, Reactivity
    Dimitri Coucouvanis; Fiscal Year: 2005
    ..for the Fe/M/S centers in the nitrogenases and alternate nitrogenases that contain vanadium or iron in place of molybdenum. The new types of Fe/S clusters that will be synthesized are designed as models for the P- clusters of ..
  24. INORGANIC ION EXCHANGER FOR USE IN 82SR/82RB SEPARATIONS
    Paul Sylvester; Fiscal Year: 2000
    ..82Sr is produced by the irradiation of rubidium or molybdenum targets followed by the extraction of 82Sr using ion exchange techniques...
  25. NITROGENASE MECHANISM AND ASSEMBLY
    Thomas Poulos; Fiscal Year: 2002
    ..proposed herein will also focus on the molecular mechanism of the insertion of one metal cluster, the iron-molybdenum cofactor, into the MoFe protein...
  26. Synthetic Routes to a Model of the Nitrogenase Cofactor
    MIRIAM BENNETT; Fiscal Year: 2006
    ..The iron-molybdenum cofactor (FeMoco) of the nitrogenase enzyme is the site of dinitrogen reduction to ammonia...
  27. BIOCHEMICAL STUDIES OF ARSENITE AND SULFITE OXIDASE
    Russ Hille; Fiscal Year: 1990
    A comprehensive study of two molybdenum-containing hydroxylases is proposed, with the goal of fully characterizing them from a physical and kinetic standpoint...
  28. COMPLEXES OF MOLYBDENUM WITH STERICALLY-HINDERED THIOLS
    Jon Zubieta; Fiscal Year: 1990
    b>Molybdenum plays an essential role in the biological activity of the metalloenzyme nitrogenase, which is responsible for the initial stages of nitrogen fixation...
  29. MOLYBDENUM AND THE MOLYBDENUM COFACTOR IN HEALTH
    K Rajagopalan; Fiscal Year: 2003
    DESCRIPTION (Verbatim from the Applicant's Abstract): The molybdenum cofactor, a complex of Mo with an organic molecule termed molybdopterin, is a common component of the three human molybdoenzymes sulfite oxidase, xanthine dehydrogenase ..
  30. STRUCTURE AND FUNCTION OF ENZYMES--ROLE OF METALS
    K Rajagopalan; Fiscal Year: 2007
    Molybdopterin is the essential, invariant component of the cofactors of all mononuclear molybdenum and tungsten-containing enzymes. Most prokaryotic enzymes contain dinucleotide forms of molybdopterin complexed with GMP, AMP, CMP or IMP...
  31. OXIDANT PRODUCTION BY ENDOTHELIAL CELL XANTHINE OXIDASE
    Lance Terada; Fiscal Year: 1999
    ..vascular disease, increases the transcription of XO-XDH and also leads to sulfuration and activation of the molybdenum active site...
  32. International Conference on Biological Inorganic Chemistry
    Dimitri Coucouvanis; Fiscal Year: 2005
    ..Design, Protein Folding Structural Dynamics, Bioorganometallic, Electron Transfer, Theoretical Calculations, Molybdenum and Tungsten, Zinc, Vanadium, Nitrogenase, Metalloenzyme Radical Catalysts, Hemes, Environmental Bioinorganic, ..
  33. MECHANISTIC STUDIES OF DIOXO MOLYBDENUM ENZYMES
    Russ Hille; Fiscal Year: 1999
    A mechanistic and spectroscopic study of two dioxo molybdenum enzymes is proposed, focusing on the various forms of enzyme encountered in the course of turnover and the characterization of their electronic structure...
  34. INORGANIC ION EXCHANGER FOR USE IN 82SR/82RB SEPARATIONS
    Hariprasad Gali; Fiscal Year: 2002
    ..The parent 82Sr is an expensive isotope, and is produced by the proton irradiation of target materials (e.g. molybdenum) followed by extensive processing to isolate pure 82Sr...
  35. INVESTIGATIONS OF BIOMIMETIC NITROGEN FIXATION
    T George; Fiscal Year: 1991
    ..investigate the mechanism of ammonia formation in a biomimetic system involving dinitrogen (N2) complexes of molybdenum. In addition the mechanism of hydrazine formation in this same system will be studied...
  36. Computational Investigation of Asymmetric Allylic Alkylation Reactions
    Buck Taylor; Fiscal Year: 2013
    ..Specifically, the mechanisms of molybdenum- and iridium-catalyzed allylic alkylation reactions will be studied computationally to ascertain the steric and ..
  37. FUNCTIONS OF NIF ASSOCIATED PROTEINS
    Gary Roberts; Fiscal Year: 1990
    ..characterizing the purified proteins and analyzing their function in vivo and in vitro by assays aimed at molybdenum metabolism...
  38. Dearomatization of Aromatic Heterocyles
    W Dean Harman; Fiscal Year: 2005
    ..will develop dearomatization reactions for aromatic heterocycles, utilizing an entirely new class of rhenium and molybdenum chiral-at-metal dearomatization agents that allow greater versatility in the scope of reactions, better handling ..
  39. Crystal Structure Determination of Molybdate Transporter
    PAMELA LUM; Fiscal Year: 2004
    ..The molybdate transporter is a member of the family. It provides the essential molybdenum cofactor to many molybdo-enzymes in bacteria, plants and animals...
  40. V-Fe-S Clusters--Towards the Synthesis of FeVco
    CRAIG MCLAUCHLAN; Fiscal Year: 2001
    ..The elucidation of the iron-molybdenum cofactor (FeMoco) structure of nitrogenase allowed a more definitive look at how Nature managed to combine 8 ..
  41. Nitrogenase Assembly Mechanism
    Markus W Ribbe; Fiscal Year: 2013
    ..spectroscopic and structural approaches, we propose to investigate how M-cluster, the active center of molybdenum nitrogenase, is assembled...
  42. APPLICATIONS OF A RESONANCE RAMAN SPECTROMETER
    Russ Hille; Fiscal Year: 1991
    ..Applications of the instrument being requested include: (1) structural and mechanistic studies of the molybdenum center of xanthine oxidase and arsenite oxidase; (2) investigations of the heme centers of chicken liver sulfite ..
  43. EPR STUDIES OF DINUCLEAR METAL CLUSTERS IN PROTEINS
    MICHAEL HENDRICH; Fiscal Year: 2002
    ..Many metals of biological importance such as vanadium, chromium, manganese, iron, cobalt,, nickel, copper, and molybdenum, have unpaired electrons that give rise to a new electronic spin and a resultant magnetic moment...
  44. NEW CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING
    MARIUSZ KOZIK; Fiscal Year: 1991
    ..It is proposed to introduce paramagnetic transition metal-substituted heteropoly complexes of tungsten and molybdenum as contrast agents for Magnetic Resonance Imaging...
  45. RELATIVE HEALTH RISKS OF DIESEL EMISSION CONTROL SYSTEMS
    Susan Bagley; Fiscal Year: 1992
    ..and an oxidation catalytic converter will be tested together on a load-haul-dump vehicle in an underground molybdenum mine. At each mine, samples will be collected by BOM personnel for chemical and biological analyses at MTU...
  46. VIBRATIONAL DYNAMICS IN BIOLOGICAL (HEME) SYSTEMS
    MIRIAM SIMPSON; Fiscal Year: 2002
    ..Initial studies will focus upon a model system: electron transfer in Zn-tetraphenyl porphyrin with a molybdenum ligand...
  47. ENCHANCED RESOLUTION MAMMOGRAPHY X-RAY DETECTOR
    Edward Johnson; Fiscal Year: 1993
    ..It will detect, with 100 percent efficiency, the characteristic X-rays produced by standard molybdenum targets, and will do so with very high resolution, about 60 microns (roughly half the diameter of a human hair)...
  48. ULTRA HIGH FIELD NMR SPECTROMETER
    LEONARD SPICER; Fiscal Year: 1990
    ..DNA processing enzymes 7. Macromolecular binding sites of molybdenum cofactors 8. Characterization and structure of complex sugars and macrolide antibiotics 9...
  49. PHASE III TRIAL OF TETRATHIOMOLYBDATE IN PRIMARY BILIAR*
    George Brewer; Fiscal Year: 2007
    ..Abstract Not Provided ..
  50. SYNTHESIS OF MOLYBDOPTERIN AND THE MOLYBDENUM COFACTOR
    Edward Taylor; Fiscal Year: 1991
    The molybdenum cofactor consists, inter alia, of a pterin component termed molybdopterin complexed with molybdenum...
  51. NOVEL X-RAY MAMMOGRAPHY SYSTEM DEVELOPMENT
    LOUIS KOPPEL; Fiscal Year: 1991
    ..Since the new system will use robust high-voltage tungsten-target x-ray tubes, rather than the conventional molybdenum tubes, an increase in tube life and a reduction in replacement-cycle costs will also result...
  52. The Molybdenum Cofactor: Biosynthesis and Function
    Hermann Schindelin; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): The molybdenum cofactor (Moco) consists of a mononuclear molybdenum coordinated to the sulfur atoms of a unique dithiolene group which is part of a substituted pterin derivative termed ..
  53. CCD DETECTOR TO UPGRADE AN X-RAY DIFFRACTOMETER
    KARL HAGEN; Fiscal Year: 2000
    ..new technology recently introduced to crystallography by the coupling of a CCD detector to phosphors tuned to molybdenum and copper radiation affords data of quality far superior to the 1970's technology that we currently use...
  54. METAL CENTERS IN BIOLOGICAL SYSTEMS
    Thomas Spiro; Fiscal Year: 1993
    ..The coupling of Fe-S cluster and siroheme chemistry in sulfite reductase will be probed. Molybdenum redox proteins will be studied to elucidate the structure of the active molybdopterin cofactor...
  55. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  56. Controlled Catalytic Reduction of Dinitrogen at a Transition Metal Center
    Richard R Schrock; Fiscal Year: 2010
    ..to design new trianionic triamidoamine ligands that would allow reduction of dinitrogen under mild conditions at molybdenum, and we want to expand the chemistry of triamidoamine ligands to iron and ruthenium...
  57. Proteomic determination of arsenical action
    Partha Basu; Fiscal Year: 2005
    ..These studies will greatly expand the understanding of the biochemical activation of vascular cell signaling that is relevant to arsenic-related vascular diseases. ..
  58. Molybdenum Pterin-Dithiolene Complexes for Model Studies of the Catalytic Site of
    SHARON BURGMAYER; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): The relationship of molybdenum to health is far less well known by the general public than that of familiar essential metals iron, copper and zinc...
  59. IN VITRO INVESTIGATION OF SLIDING MECHANICS
    Robert Kusy; Fiscal Year: 2002
    ..abstract_text> ..
  60. Allenic [2 + 2 + 1] Reactions Enabling Syntheses of Natural Products with 7-Membe
    Kay M Brummond; Fiscal Year: 2010
    ..Grayanotoxin is an important molecular tool for deciphering the mechanism for gating functions of the sodium ion channels. ..
  61. PORPHYRAZINE TUMOR CONTRAST AGENTS
    Brian Hoffman; Fiscal Year: 2004
    ..GOAL: To correlate structural modifications of near-it absorbing/emitting pzs with their biological activity, so as to develop optimized, iv-deliverable optical contrast agents. ..