Genomes and Genes
Summary: A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.94. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase. (From Dorland, 27th ed)
Publications310 found, 100 shown here
- Variation in molybdenum content across broadly distributed populations of Arabidopsis thaliana is controlled by a mitochondrial molybdenum transporter (MOT1)Ivan Baxter
Bindley Bioscience Center, Purdue University, West Lafayette, Indiana, United States of America
PLoS Genet 4:e1000004. 2008b>Molybdenum (Mo) is an essential micronutrient for plants, serving as a cofactor for enzymes involved in nitrate assimilation, sulfite detoxification, abscisic acid biosynthesis, and purine degradation...
- Molecular characterization of the gene cluster coxMSL encoding the molybdenum-containing carbon monoxide dehydrogenase of Oligotropha carboxidovoransU Schübel
Lehrstuhl fur Mikrobiologie, Universitat Bayreuth, Germany
J Bacteriol 177:2197-203. 1995..Sequence analysis suggested association of molybdopterin cytosine dinucleotide and flavin adenine dinucleotide with CoxL and of the [2Fe-2S] clusters with CoxS...
- A late methanogen origin for molybdenum-dependent nitrogenaseE S Boyd
Department of Chemistry and Biochemistry and the Astrobiology Biogeocatalysis Research Center, Montana State University, Bozeman, MT, USA
Geobiology 9:221-32. 2011..2.5-2.0 Ga). It has been suggested that the iron (Fe)- or vanadium (V)-dependent nitrogenase rather than molybdenum (Mo)-dependent form was responsible for dinitrogen fixation during this time because oceans were depleted in Mo ..
- Essential metals for nitrogen fixation in a free-living N₂-fixing bacterium: chelation, homeostasis and high use efficiencyJ P Bellenger
Department of Geosciences, PEI, Guyot Hall, Princeton University, Princeton, NJ 08544, USA
Environ Microbiol 13:1395-411. 2011..We conclude that A. vinelandii is well adapted to fix nitrogen in metal-limited soil environments...
- Maternal-foetal status of copper, iron, molybdenum, selenium and zinc in obese gestational diabetic pregnanciesE Al-Saleh
Department of Obstetrics and Gynecology Faculty of Medicine, University of Kuwait, P O Box 24923, Safat, 13110, Kuwait
Acta Diabetol 44:106-13. 2007..We conclude that obesity is not associated with significant alterations in antioxidant enzyme status in gestational diabetes and only with relatively minor alterations in status of some essential trace elements...
- Biosynthesis of the iron-molybdenum cofactor of nitrogenaseLuis M Rubio
Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
Annu Rev Microbiol 62:93-111. 2008The iron-molybdenum cofactor (FeMo-co), located at the active site of the molybdenum nitrogenase, is one of the most complex metal cofactors known to date...
- Identification of an Arabidopsis solute carrier critical for intracellular transport and inter-organ allocation of molybdateA Gasber
Plant Physiology, Technical University of Kaiserslautern, Kaiserslautern, Germany
Plant Biol (Stuttg) 13:710-8. 2011Plants represent an important source of molybdenum in the human diet. Recently, MOT1 has been identified as a transport protein responsible for molybdate import in Arabidopsis thaliana L...
- Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelatorSeiko Ishida
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA
Cancer Cell 17:574-83. 2010..Our results identify the copper transporter as a therapeutic target, which can be manipulated with copper chelating drugs to selectively enhance the benefits of platinum-containing chemotherapeutic agents...
- Nitrogenase phylogeny and the molybdenum dependence of nitrogen fixation in Methanococcus maripaludisP S Kessler
Department of Microbiology, University of Washington, Seattle 98195, USA
J Bacteriol 179:541-3. 1997We studied the effects of molybdenum, vanadium, and tungsten on the diazotrophic growth of Methanococcus maripaludis. Mo stimulated growth, with a maximal response at 4.0 microM, while V had no effect at any concentration tested...
- Active site geometry and substrate recognition of the molybdenum hydroxylase quinoline 2-oxidoreductaseIrena Bonin
, , 82152 Martinsried, Germany
Structure 12:1425-35. 2004..Qor is a member of the molybdenum hydroxylases...
- The molybdate-responsive Escherichia coli ModE transcriptional regulator coordinates periplasmic nitrate reductase (napFDAGHBC) operon expression with nitrate and molybdate availabilityPaul M McNicholas
Department of Microbiology, University of California, Los Angeles, Los Angeles, California 90095 1489, USA
J Bacteriol 184:3253-9. 2002..The upstream ModE regulatory site functions to override nitrate control of napF gene expression when the essential enzyme component, molybdate, is limiting in the cell environment...
- Molybdenum and tungsten enzymes: the xanthine oxidase familyCarlos D Brondino
Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Campus Universitario, 3000 Santa Fe, Argentina
Curr Opin Chem Biol 10:109-14. 2006Mononuclear molybdenum and tungsten are found in the active site of a diverse group of enzymes that, in general, catalyze oxygen atom transfer reactions...
- The formylmethanofuran dehydrogenase isoenzymes in Methanobacterium wolfei and Methanobacterium thermoautotrophicum: induction of the molybdenum isoenzyme by molybdate and constitutive synthesis of the tungsten isoenzymeA Hochheimer
Max Planck Institut fur terrestrische Mikrobiologie, Fachbereich Biologie, Philipps Universitat, Marburg, Germany
Arch Microbiol 170:389-93. 1998..thermoautotrophicum have been shown to contain two isoenzymes, a tungsten-containing isoenzyme (Fwd) and a molybdenum-containing isoenzyme (Fmd)...
- The role of copper in tumour angiogenesisSarah A Lowndes
Cancer Research UK Medical Oncology Unit, The Churchill Hospital, Oxford OX3 7LJ, UK
J Mammary Gland Biol Neoplasia 10:299-310. 2005....
- Influence of soil properties on molybdenum uptake and elimination kinetics in the earthworm Eisenia andreiMaria Díez-Ortiz
Department of Animal Ecology, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
Chemosphere 80:1036-43. 2010This study aimed at determining the uptake and elimination kinetics of molybdenum in the earthworm Eisenia andrei, and the influence of soil properties on molybdenum bioaccumulation...
- Tetrathiomolybdate causes formation of hepatic copper-molybdenum clusters in an animal model of Wilson's diseaseGraham N George
Stanford Synchrotron Radiation Laboratory, Stanford Linear Accelerator Center, 2575 Sand Hill Road, MS 69, Menlo Park, California 94025, USA
J Am Chem Soc 125:1704-5. 2003..70 A. Each Cu is coordinated to 3-4 sulfurs at 2.28 A with approximately one Mo neighbor at 2.70 A. These results indicate the formation of a biologically novel molybdenum-copper-sulfur cluster.
- Experimental copper deficiency, chromium deficiency and additional molybdenum supplementation in goats--pathological findingsH Aupperle
Institut für Veterinär Pathologie der Universität Leipzig, Leipzig, Germany
Acta Vet Scand 42:311-21. 2001..study shows that liver, pancreas and skin are mainly affected by a long term deficiency of copper and the findings are complicated by molybdenum application while chromium deficiency produced no histomorphological effects in our study.
- Functional characterization of the Bradyrhizobium japonicum modA and modB genes involved in molybdenum transportMaria J Delgado
Departamento de Microbiologia del Suelo y Sistemas Simbioticos, Estacion Experimental del Zaidin, CSIC, PO Box 419, 18080 Granada, Spain
Microbiology 152:199-207. 2006..japonicum modA mutant grown in a medium without molybdate supplementation. These findings indicate that transcription of the B. japonicum modABC genes is repressed by molybdate...
- Hypersensitivity of Escherichia coli Delta(uvrB-bio) mutants to 6-hydroxylaminopurine and other base analogs is due to a defect in molybdenum cofactor biosynthesisS G Kozmin
Department of Genetics, Sankt Petersburg State University, Saint Petersburg, Russia
J Bacteriol 182:3361-7. 2000..The moeAB operon provides one of a large number of genes responsible for biosynthesis of the molybdenum cofactor...
- Caeruloplasmin: plasma copper ratios in cowsS B Telfer
Vet Rec 159:607-8; author reply 608. 2006
- Tetrathiomolybdate anticopper therapy for Wilson's disease inhibits angiogenesis, fibrosis and inflammationG J Brewer
Department of Human Genetics and Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
J Cell Mol Med 7:11-20. 2003..Most recently, it has been found that TM has antifibrotic and antiinflammatory effects through inhibition of profibrotic and proinflammatory cytokines...
- Tetrathiomolybdate, a copper chelator for the treatment of Wilson disease, pulmonary fibrosis and other indicationsValentina Medici
University of California, Davis, Division of Gastroenterology and Hepatology, Department of Internal Med, 4150 V Street, Suite 3500, Sacramento, CA 95817, USA
IDrugs 11:592-606. 2008..TTM is predicted to most likely find a niche in the therapy of Wilson disease, for which current treatment options are limited...
- Molybdenum-associated pituitary endocrinopathy in sheep treated with ammonium tetrathiomolybdateS Haywood
Department of Veterinary Pathology, University of Liverpool, Liverpool L69 3BX, UK
J Comp Pathol 130:21-31. 2004..Excess molybdenum (Mo) retention (P<0...
- Tetrathiomolybdate induces doxorubicin sensitivity in resistant tumor cell linesKyu Kwang Kim
Molecular Therapeutics Laboratory, Program in Women s Oncology, Department of Obstetrics and Gynecology, Women and Infants Hospital, Alpert Medical School, Brown University, Providence, RI, USA
Gynecol Oncol 122:183-9. 2011..This study tests the hypothesis that TM can modulate antioxidants in tumor cells and render doxorubicin resistant tumor cells sensitive to doxorubicin...
- Antitumor activity of nifurtimox is enhanced with tetrathiomolybdate in medulloblastomaKaren S Koto
Vermont Cancer Center, University of Vermont College of Medicine, Burlington, VT, USA
Int J Oncol 38:1329-41. 2011..Taken together, our results suggest nifurtimox and TM act synergistically in medulloblastoma cells in vitro, and that this combination warrants further studies as a new treatment for medulloblastoma...
- A molybdenum complex bearing PNP-type pincer ligands leads to the catalytic reduction of dinitrogen into ammoniaKazuya Arashiba
Institute of Engineering Innovation, School of Engineering, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 8656, Japan
Nat Chem 3:120-5. 2011..of ammonia being produced with the catalyst (12 equiv. of ammonia are produced based on the molybdenum atom of the catalyst)...
- Trace elements status in diabetes mellitus type 2: possible role of the interaction between molybdenum and copper in the progress of typical complicationsCrescencio Rodríguez Flores
Department of Chemistry, University of Guanajuato, 36000 Guanajuato, Mexico
Diabetes Res Clin Pract 91:333-41. 2011..In such approach, aluminum, vanadium, chromium, manganese, cobalt, nickel, copper, zinc, arsenic, selenium, molybdenum, mercury, cadmium and lead were determined by inductively coupled plasma-mass spectrometry (ICP-MS) in serum and ..
- Effects of molybdenum deficiency and defects in molybdate transporter MOT1 on transcript accumulation and nitrogen/sulphur metabolism in Arabidopsis thalianaYoko Ide
Biotechnology Research Center, University of Tokyo, 1 1 1, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
J Exp Bot 62:1483-97. 2011b>Molybdenum (Mo) is a micronutrient essential for plant growth, as several key enzymes of plant metabolic pathways contain Mo cofactor in their catalytic centres...
- Short- and long-term responses to molybdenum-99 shortages in nuclear medicineJ R Ballinger
Department of Nuclear Medicine, Guy s and St Thomas NHS Foundation Trust, and Division of Imaging Sciences and Biomedical Engineering, King s College London
Br J Radiol 83:899-901. 2010..In the long-term, stability of (99)Mo supply will rely on a combination of replacing conventional reactors and developing new technologies...
- Catalytic reduction of dinitrogen to ammonia at a single molybdenum centerDmitry V Yandulov
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 301:76-8. 2003Dinitrogen (N2) was reduced to ammonia at room temperature and 1 atmosphere with molybdenum catalysts that contain tetradentate [HIPTN3N]3- triamidoamine ligands (such as [HIPTN3N]Mo(N2), where [HIPTN3N]3- is [(3,5-(2,4,6-i-Pr3C6H2)..
- Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikisPawan Kumar
Department of Otolaryngology Head and Neck Surgery and Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
Mol Cancer 9:206. 2010..However, very little is known about the effect of TM on tumor cell function and tumor metastasis. In this study, we explored the mechanisms underlying TM-mediated inhibition of tumor metastasis...
- Influence of sulfur deficiency on the expression of specific sulfate transporters and the distribution of sulfur, selenium, and molybdenum in wheatFumie Shinmachi
Rothamsted Research, West Common, Harpenden, Hertfordshire AL52JQ, United Kingdom
Plant Physiol 153:327-36. 2010..In 2008, S, sulfate, selenium (Se), and molybdenum (Mo) concentrations and sulfate transporter gene expression were analyzed throughout development...
- Highly efficient molybdenum-based catalysts for enantioselective alkene metathesisSteven J Malcolmson
Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA
Nature 456:933-7. 2008..The new catalysts have a stereogenic metal centre and carry only monodentate ligands; the molybdenum-based complexes are prepared stereoselectively by a ligand exchange process involving an enantiomerically pure ..
- Effect of tungsten and molybdenum on growth of a syntrophic coculture of Syntrophobacter fumaroxidans and Methanospirillum hungateiCaroline M Plugge
Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB, Wageningen, The Netherlands
Arch Microbiol 191:55-61. 2009The effect of tungsten (W) and molybdenum (Mo) on the growth of Syntrophobacter fumaroxidans and Methanospirillum hungatei was studied in syntrophic cultures and the pure cultures of both the organisms...
- Oxygen, nitrate, and molybdenum regulation of dmsABC gene expression in Escherichia coliP A Cotter
Department of Microbiology, University of California, Los Angeles
J Bacteriol 171:3817-23. 1989..dmsA'-lacZ expression was also altered in chlD strains that are defective in molybdenum transport but not in chlA and chlE strains that are defective in molybdopterin cofactor biosynthesis, thus ..
- Syntheses, spectroscopies and structures of molybdenum(VI) complexes with homocitrateZhao Hui Zhou
Department of Chemistry, College of Chemistry and Chemical Engineering and State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen 361005, China
Inorg Chem 45:8447-51. 2006Initial investigations into the possible role of homocitric acid in iron molybdenum cofactor (FeMo-co) of nitrogenase lead us to isolate and characterize two tetrameric molybdate(VI) species...
- Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenumJohn D Meeker
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA
Fertil Steril 93:130-40. 2010..To explore associations between exposure to metals and male reproductive hormone levels...
- Electroanalytical determination of tungsten and molybdenum in proteinsP L Hagedoorn
Kluyver Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
Anal Biochem 297:71-8. 2001..An electroanalytical tungsten determination has successfully been adapted to determine the tungsten and molybdenum content in enzymes...
- A structure-based catalytic mechanism for the xanthine oxidase family of molybdenum enzymesR Huber
Max Planck Institut fur Biochemie, Martinsried, Germany
Proc Natl Acad Sci U S A 93:8846-51. 1996The crystal structure of the xanthine oxidase-related molybdenum-iron protein aldehyde oxido-reductase from the sulfate reducing anaerobic Gram-negative bacterium Desulfovibrio gigas (Mop) was analyzed in its desulfo-, sulfo-, oxidized, ..
- Cloning, expression, and sequence analysis of the three genes encoding quinoline 2-oxidoreductase, a molybdenum-containing hydroxylase from Pseudomonas putida 86M Blase
Institut für Mikrobiologie 250, Universitat Hohenheim, D 70593 Stuttgart, Germany
J Biol Chem 271:23068-79. 1996..putida KT2440 clone. The amino acid sequences of Qor show significant homology to various prokaryotic molybdenum containing hydroxylases and to eukaryotic xanthine dehydrogenases...
- In vitro molybdenum ligation to molybdopterin using purified componentsJason D Nichols
Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 280:7817-22. 2005We have previously shown that Escherichia coli MoeA and MogA are required in vivo for the final step of molybdenum cofactor biosynthesis, the addition of the molybdenum atom to the dithiolene of molybdopterin...
- Tetrathiomolybdate therapy protects against bleomycin-induced pulmonary fibrosis in miceGeorge J Brewer
Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 0618, USA
J Lab Clin Med 141:210-6. 2003..The protection afforded by TM was also reflected in significantly reduced bleomycin-induced body-weight loss. In the next phase of this work, we will seek to determine the mechanisms by which TM brings about this therapeutic benefit...
- Evidence for nifU and nifS participation in the biosynthesis of the iron-molybdenum cofactor of nitrogenaseDehua Zhao
Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
J Biol Chem 282:37016-25. 2007..Although NifH contains a [4Fe-4S] cluster, the NifDK component carries two complex metalloclusters, the iron-molybdenum cofactor (FeMo-co) and the [8Fe-7S] P-cluster...
- Characterization of the NifS-like domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfurationTorsten Heidenreich
Department of Plant Biology, Technical University of Braunschweig, 38023 Braunschweig, Germany
J Biol Chem 280:4213-8. 2005The molybdenum cofactor sulfurase ABA3 from Arabidopsis thaliana specifically regulates the activity of the molybdenum enzymes aldehyde oxidase and xanthine dehydrogenase by converting their molybdenum cofactor from the desulfo-form into ..
- Coordination of selenium to molybdenum in formate dehydrogenase H from Escherichia coliV N Gladyshev
Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
Proc Natl Acad Sci U S A 91:7708-11. 1994..This ligand could be the Se of a selenocysteine residue, sulfur of a cysteine residue, or, in the case of a serine residue, oxygen...
- NarJ is a specific chaperone required for molybdenum cofactor assembly in nitrate reductase A of Escherichia coliF Blasco
Laboratoire de Chimie Bacterienne, IBSM, CNRS, Marseilles, France
Mol Microbiol 28:435-47. 1998..Fluorescence, electron paramagnetic resonance (EPR) spectroscopy and molybdenum quantification based on inductively coupled plasma emission spectroscopy (ICPES) clearly indicate that, in the ..
- Structure and function of molybdopterin containing enzymesM J Romao
Instituto de Tecnologia Quimica e Biologica, Oeiras, Portugal
Prog Biophys Mol Biol 68:121-44. 1997..In this review we give an account of the related spectroscopic information and the crystallographic results, with emphasis on structure-function studies...
- Biochemical and structural analysis of the molybdenum cofactor biosynthesis protein MobAAnnika Guse
Departments of Molecular Microbiology and Biological Chemistry, John Innes Centre, Norwich NR4 7UH, United Kingdom
J Biol Chem 278:25302-7. 2003Molybdopterin guanine dinucleotide (MGD) is the form of the molybdenum cofactor that is required for the activity of most bacterial molybdoenzymes...
- Crystallographic analysis of the MoFe protein of nitrogenase from a nifV mutant of Klebsiella pneumoniae identifies citrate as a ligand to the molybdenum of iron molybdenum cofactor (FeMoco)Suzanne M Mayer
Department of Biological Chemistry, John Innes Centre, Norwich NR4 7UH, United Kingdom
J Biol Chem 277:35263-6. 2002..direct evidence that the organic acid citrate is not just present, but replaces homocitrate as a ligand to the molybdenum atom of the iron molybdenum cofactor (FeMoco)...
- Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesisQuintin Pan
Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Cancer Res 62:4854-9. 2002..Our study suggests that a major mechanism of the antiangiogenic effect of copper deficiency induced by TM is suppression of NFkappaB, contributing to a global inhibition of NFkappaB-mediated transcription of proangiogenic factors...
- A widespread riboswitch candidate that controls bacterial genes involved in molybdenum cofactor and tungsten cofactor metabolismElizabeth E Regulski
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
Mol Microbiol 68:918-32. 2008We have identified a highly conserved RNA motif located upstream of genes encoding molybdate transporters, molybdenum cofactor (Moco) biosynthesis enzymes, and proteins that utilize Moco as a coenzyme...
- Cadmium, lead, and other metals in relation to semen quality: human evidence for molybdenum as a male reproductive toxicantJohn D Meeker
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
Environ Health Perspect 116:1473-9. 2008..g., zinc, copper) and nonessential (e.g., cadmium, lead), is inconsistent. Most studies to date used small sample sizes and were unable to account for important covariates...
- Molybdate transport through the plant sulfate transporter SHST1Kate L Fitzpatrick
School of Agriculture, Food and Wine, The University of Adelaide, Waite Campus Urrbrae, SA 5064, Australia
FEBS Lett 582:1508-13. 2008b>Molybdenum is an essential micronutrient required by plants. The mechanism of molybdenum uptake in plants is poorly understood, however, evidence has suggested that sulfate transporters may be involved...
- Antitumor activity of polyoxomolybdate, [NH3Pri]6[Mo7O24].3H2O, against, human gastric cancer modelS Mitsui
Chemical Research Laboratory, Tokyo Institute of Technology, R1-21, 4259 Nagatsuta, Midori-ku, Yokohama 226-8503, Japan
Biomed Pharmacother 60:353-8. 2006Polyoxometalates are negatively charged inorganic compounds which contain metal ions such as tungsten, molybdenum, vanadium etc. and which make clusters with the surrounding oxygen atoms. [NH3Pri]6[Mo7O24]...
- Antiangiogenic tetrathiomolybdate enhances the efficacy of doxorubicin against breast carcinomaQuintin Pan
Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Mol Cancer Ther 2:617-22. 2003..4 +/- 14.3% greater than that in doxorubicin-treated mice. These results suggest that TM may enhance the rate of pathological complete response when used in combination with an anthracycline in neoadjuvant therapy of breast carcinoma...
- A novel anti-tumor agent, polyoxomolybdate induces apoptotic cell death in AsPC-1 human pancreatic cancer cellsA Ogata
Chemical Resources Laboratory, Tokyo Institute of Technology, R1-21, 4259 Nagatsuta, Midori-ku, Yokohama 226-8503, Japan
Biomed Pharmacother 59:240-4. 2005..Polyoxomolybdates provide promising, novel anti-tumor agent, especially for the treatment of cancers that are difficult to treat...
- Phase II trial of tetrathiomolybdate in patients with advanced kidney cancerBruce G Redman
Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor 48109 0948, USA
Clin Cancer Res 9:1666-72. 2003..Tetrathiomolybdate (TM), a copper-lowering agent, has been shown in preclinical murine tumor models to be antiangiogenic. We evaluated the antitumor activity of TM in patients with advanced kidney cancer in a Phase II trial...
- Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224)F Donate
Attenuon, LLC, San Diego, CA 92121, USA
Br J Cancer 98:776-83. 2008..Thus, both SOD activity measurements and levels of EPCs may be useful biomarkers of the antiangiogenic activity of ATN-224 to be used in its clinical development...
- Proposed nomenclature for the genes involved in molybdenum metabolism in Escherichia coli and Salmonella typhimuriumK T Shanmugam
Mol Microbiol 6:3452-4. 1992
- Enzymatic and physiological properties of the tungsten-substituted molybdenum TMAO reductase from Escherichia coliJ Buc
Laboratoire de Chimie Bacterienne, CNRS, Marseille, France
Mol Microbiol 32:159-68. 1999..We have successfully substituted the molybdenum with tungsten and obtained an active tungsto-TMAO reductase...
- Genetic analysis of the modABCD (molybdate transport) operon of Escherichia coliJ A Maupin-Furlow
Department of Microbiology and Cell Science, University of Florida, Gainesville 32611, USA
J Bacteriol 177:4851-6. 1995..These results show that molybdate, after transport into cells by the ModABC proteins, is metabolized (activated?) by the products of the mol gene(s)...
- Cofactor determination and spectroscopic characterization of the selenium-dependent purine hydroxylase from Clostridium purinolyticumWilliam T Self
Laboratory of Biochemistry, National Heart, Lung and Blood Institute, National Institutes of Health, 50 South Drive MSC 8012, Bethesda, Maryland 20892-8012, USA
Biochemistry 42:11382-90. 2003..contains a labile selenium cofactor and belongs to a class of enzymes known as the selenium-dependent molybdenum hydroxylases. The presence of approximately 1.1 mol of molybdenum, 0.87 mol of selenium, and 3...
- Assessment of molybdenum toxicity in humansA Vyskocil
Département de médecine du travail et d hygiène du milieu, Faculte de Medecine, Universite de Montreal, Quebec, Canada
J Appl Toxicol 19:185-92. 1999In an attempt to define a tolerable daily intake (TDI) for molybdenum based on a toxicological risk analysis approach, a large literature survey was conducted...
- Electronic structure of bent titanocene complexes with chelated dithiolate ligandsJ Jon A Cooney
Department of Chemistry, The University of Arizona, Tucson, Arizona 85721, USA
Inorg Chem 43:8110-8. 2004..A "dithiolate-folding-effect" involving an interaction of metal and sulfur orbitals is demonstrated in complexes with arene- and enedithiolates. This effect is not observed for the alkanedithiolate in complex 3...
- Electronic structure description of the cis-MoOS unit in models for molybdenum hydroxylasesChristian J Doonan
The Department of Chemistry and Biological Chemistry, The University of New Mexico, MSC03 20601 University of New Mexico, Albuquerque, New Mexico 87131 0001, USA
J Am Chem Soc 130:55-65. 2008The molybdenum hydroxylases catalyze the oxidation of numerous aromatic heterocycles and simple organics and, unlike other hydroxylases, utilize water as the source of oxygen incorporated into the product...
- NarJ chaperone binds on two distinct sites of the aponitrate reductase of Escherichia coli to coordinate molybdenum cofactor insertion and assemblyAlexandra Vergnes
Laboratoire de Chimie Bacterienne, Institut Biologie Structurale et Microbiologie IBSM, Centre National de la Recherche Scientifique, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 09, France
J Biol Chem 281:2170-6. 2006..b>Molybdenum cofactor insertion is a tightly controlled process that involves specific interactions between the proteins that ..
- The effects of tetrathiomolybdate (TTM, NSC-714598) and copper supplementation on fertility and early embryonic development in ratsAlexander V Lyubimov
Toxicology Research Laboratory, University of Illinois at Chicago, 1940W Taylor Street, Chicago, IL 60612, USA
Reprod Toxicol 19:223-33. 2004..Dietary copper supplementation prevented the adverse sperm effects produced by 12 mg/kg/day of TTM...
- Molybdenum-containing hydroxylasesRuss Hille
Department of Molecular and Cellular Biochemistry, The Ohio State University, 333 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210, USA
Arch Biochem Biophys 433:107-16. 2005Unlike monooxygenases, molybdenum-containing hydroxylases catalyze the hydroxylation of carbon centers using oxygen derived ultimately from water, rather than O(2), as the source of the oxygen atom incorporated into the product, and do ..
- Biosynthesis and processing of the molybdenum cofactorsK V Rajagopalan
Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
Biochem Soc Trans 25:757-61. 1997
- Reaction systems related to dissimilatory nitrate reductase: nitrate reduction mediated by bis(dithiolene)tungsten complexesJianfeng Jiang
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Inorg Chem 44:1068-72. 2005..is an analogue of the active site of dissimilatory nitrate reductase which in the reduced state contains a molybdenum atom bound by two pyranopterindithiolene ligands and a cysteinate residue...
- Purification of a NifEN protein complex that contains bound molybdenum and a FeMo-Co precursor from an Azotobacter vinelandii DeltanifHDK strainBasem Soboh
Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, California 94720, USA
J Biol Chem 281:36701-9. 2006The NifEN protein complex serves as a molecular scaffold where some of the steps for the assembly of the iron-molybdenum cofactor (FeMo-co) of nitrogenase take place...
- Molybdate transport and regulation in bacteriaA M Grunden
Department of Microbiology and Cell Science, 110700, University of Florida, Gainesville, FL 32611 0700, USA
Arch Microbiol 168:345-54. 1997..coli and Klebsiella pneumoniae, while other dinitrogen-fixing organisms appear to have a molybdenum storage protein...
- The role of molybdenum in agricultural plant productionBrent N Kaiser
Discipline of Wine and Horticulture, School of Agriculture and Wine, University of Adelaide, PMB 1 Glen Osmond, South Australia 5064, Australia
Ann Bot 96:745-54. 2005The importance of molybdenum for plant growth is disproportionate with respect to the absolute amounts required by most plants...
- Molybdenum and tungsten in biologyRuss Hille
Dept of Molecular and Cellular Biochemistry and The Protein Research Group, The Ohio State University, Columbus, OH 43210 1218, USA
Trends Biochem Sci 27:360-7. 2002b>Molybdenum is the only second-row transition metal that is required by most living organisms, and the few species that do not require molybdenum use tungsten, which lies immediately below molybdenum in the periodic table...
- Copper chelation represses the vascular response to injuryLazar Mandinov
Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough 04074, USA
Proc Natl Acad Sci U S A 100:6700-5. 2003....
- Effects of molybdenum on fertility of male ratsRatna Pandey
Department of Zoology, University of Lucknow, UP, India
Biometals 15:65-72. 2002..Accumulation of molybdenum in testes, epididymides and seminal vesicles was also observed...
- Cell biology of molybdenumRalf R Mendel
Department of Plant Biology, Technical University of Braunschweig, Humboldtstrasse 1, 38106 Braunschweig, Germany
Biochim Biophys Acta 1763:621-35. 2006The transition element molybdenum (Mo) is of essential importance for (nearly) all biological systems as it is required by enzymes catalyzing diverse key reactions in the global carbon, sulfur and nitrogen metabolism...
- Biology of the molybdenum cofactorRalf R Mendel
Institute of Plant Biology, Technical University of Braunschweig, 38106 Braunschweig, Germany
J Exp Bot 58:2289-96. 2007The transition element molybdenum (Mo) is an essential micronutrient for plants where it is needed as a catalytically active metal during enzyme catalysis...
- Structure of the molybdopterin-bound Cnx1G domain links molybdenum and copper metabolismJochen Kuper
Department of Plant Biology, Technical University, Spielmannstrasse 7, D-38106 Braunschweig, Germany
Nature 430:803-6. 2004The molybdenum cofactor is part of the active site of all molybdenum-dependent enzymes, except nitrogenase. The molybdenum cofactor consists of molybdopterin, a phosphorylated pyranopterin, with an ene-dithiolate coordinating molybdenum...
- Tungstate Uptake by a highly specific ABC transporter in Eubacterium acidaminophilumK Makdessi
, , Kurt-Mothes-Strasse 3, 06120 Halle, Germany
J Biol Chem 276:24557-64. 2001..They should participate in the biosynthesis of the pterin cofactor that is present in molybdenum- and tungsten-containing enzymes except nitrogenase.
- Tetrathiomolybdate promotes tumor necrosis and prevents distant metastases by suppressing angiogenesis in head and neck cancerBasil Hassouneh
Department of Otolaryngology Head and Neck Surgery, University of Michigan, 1500 East Medical Centre Drive, 1904 Taubman Center, Ann Arbor, MI 48109, USA
Mol Cancer Ther 6:1039-45. 2007..Taken together, these results show that tetrathiomolybdate can act long-term as a suppressor of vascularity and inhibit the growth of metastasis in this model of HNSCC...
- Orphan SelD proteins and selenium-dependent molybdenum hydroxylasesDaniel H Haft
Department of Bioinformatics, J, Craig Venter Institute, Rockville, MD 20850, USA
Biol Direct 3:4. 2008..in selenouridine-modified tRNAs, in proteins translated with selenocysteine, and in the selenium-dependent molybdenum hydroxylases (SDMH). The first two uses both require the selenophosphate synthetase gene, selD...
- A mutation in the gene for the neurotransmitter receptor-clustering protein gephyrin causes a novel form of molybdenum cofactor deficiencyJ Reiss
Institut für Medizinische Physik und Biophysik der Universität Münster, D 48149 Munster, Germany
Am J Hum Genet 68:208-13. 2001..comparison revealed homologies between gephyrin and proteins necessary for the biosynthesis of the universal molybdenum cofactor (MoCo)...
- Application of molybdenum and phosphate modified kaolin in electrochemical treatment of paper mill wastewaterHongzhu Ma
Institute of Energy Chemistry, College of Chemistry and Materials Science, Shaanxi Normal University, Xi an 710062, China
J Hazard Mater 145:417-23. 2007..The electrochemical degradation of pulp and paper mill wastewater catalyzed by molybdenum and phosphate (Mo-P) modified kaolin with graphite as anode and cathode was investigated...
- Comparison of anti-hyperglycemic effect amongst vanadium, molybdenum and other metal maltol complexesKatherine H Thompson
Medicinal Inorganic Chemistry Group, Chemistry Department, University of British Columbia, Vancouver, BC, Canada V6T 1Z1
J Inorg Biochem 98:683-90. 2004..6 mmolkg(-1) by oral gavage in streptozotocin (STZ)-diabetic rats within 72 h of administration of compound...
- Cobalt-chromium-molybdenum alloy causes metal accumulation and metallothionein up-regulation in rat liver and kidneyStig S Jakobsen
Department of Neurobiology, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
Basic Clin Pharmacol Toxicol 101:441-6. 2007Cobalt-chromium-molybdenum (CoCrMo) metal-on-metal hip prosthesis has had a revival due to their excellent wear properties...
- Copper deficiency as an anti-cancer strategyV L Goodman
Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109, USA
Endocr Relat Cancer 11:255-63. 2004..Promising results in vitro, in pre-clinical animal models and in an early (phase I) clinical trial have led to ongoing phase II evaluation of TM in patients with advanced cancers...
- Sulfur K-edge XAS of WVO vs. MoVO bis(dithiolene) complexes: contributions of relativistic effects to electronic structure and reactivity of tungsten enzymesAdam L Tenderholt
Department of Chemistry, Stanford University, USA
J Inorg Biochem 101:1594-600. 2007b>Molybdenum- or tungsten-containing enzymes catalyze oxygen atom transfer reactions involved in carbon, sulfur, or nitrogen metabolism...
- Synthetic analogues and reaction systems relevant to the molybdenum and tungsten oxotransferasesJohn H Enemark
Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
Chem Rev 104:1175-200. 2004
- The tetrahydropyranopterin structure of the sulfur-free and metal-free molybdenum cofactor precursorJosé Angel Santamaria-Araujo
Department of Plant Biology, Technical University of Braunschweig, D 38128 Braunschweig, Germany
J Biol Chem 279:15994-9. 2004The molybdenum cofactor (Moco), a highly conserved pterin compound coordinating molybdenum (Mo), is required for the activity of all Mo-dependent enzymes with the exception of nitrogenase...
- Differential effects of vanadium, tungsten and molybdenum on inhibition of glucose formation in renal tubules and hepatocytes of control and diabetic rabbits: beneficial action of melatonin and N-acetylcysteineA Kiersztan
Department of Metabolic Regulation, Institute of Biochemistry, Warsaw University, Warszawa, Poland
Mol Cell Biochem 261:9-21. 2004..As serum glucose levels were also significantly diminished by vanadium+melatonin treatment of diabetic animals, the combination therapy of vanadium compounds and melatonin needs a careful evaluation...
- Regulation of narK gene expression in Escherichia coli in response to anaerobiosis, nitrate, iron, and molybdenumT Kolesnikow
Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024
J Bacteriol 174:7104-11. 1992..Although the role of the narK gene product in cell metabolism remains uncertain, the pattern of narK gene expression is consistent with a proposed role of NarK in nitrate uptake by the cell for nitrate-linked electron transport...
- Cancer therapy with tetrathiomolybdate: antiangiogenesis by lowering body copper--a reviewGeorge J Brewer
Department of Human Genetics and Department of Internal Medicine, University of Michigan Medical School, 4009 Buhl Building, Ann Arbor, MI 48109 0618, USA
Integr Cancer Ther 1:327-37. 2002..The authors speculate that the copper level is a primitive angiogenesis and growth-signaling regulator that has been retained throughout evolution...
- Thienyl carboxylate ligands bound to and bridging MM quadruple bonds, M = Mo or W: models for polythiophenes incorporating MM quadruple bondsMatthew J Byrnes
Department of Chemistry, The Ohio State University, 100 W. 18th Avenue, Columbus, Ohio 43210-1185, USA
Inorg Chem 43:6334-44. 2004..2THF is reported, on the basis of a single crystal X-ray diffraction study. These compounds provide insight into the expected properties of related dimetalated polythiophenes incorporating MM quadruple bonds...
- A family of dioxo-molybdenum(VI) complexes of N2X heteroscorpionate ligands of relevance to molybdoenzymesBrian S Hammes
Department of Chemistry and Biochemistry, San Diego State University, San Diego, California 92182-1030, USA
Inorg Chem 43:7800-6. 2004....
- Cubic, hydrogen-bonded (10,3)-a networks in the family [C(NH2)3][N(CH3)4][XO4] (X = S, Cr, and Mo)Brendan F Abrahams
School of Chemistry, University of Melbourne, Victoria 3010, Australia
Angew Chem Int Ed Engl 43:6157-60. 2004
- Charge-transfer hybrids containing covalently bonded polyoxometalates and ferrocenyl unitsJeonghee Kang
Departments of Chemistry, University of Missouri-Kansas City, Kansas City, Missouri 64110, and University of Kansas, Lawrence, Kansas 66045, USA
Inorg Chem 43:6408-13. 2004..For the one with two ferrocenyl units, a lower reduction potential and a two-electron oxidation wave are observed, indicating negligible electronic interactions between the two ferrocenyl units...
- Synthesis, structure, and catalytic properties of V(IV), Mn(III), Mo(VI), and U(VI) complexes containing bidentate (N, O) oxazine and oxazoline ligandsKaruppasamy Kandasamy
Departments of Chemistry, Indian Institute of Technology, Bombay, Powai, Mumbai 400 076, India
Inorg Chem 43:5704-13. 2004..The catalytic activity of complexes 4-9 for oxidation of styrene with tert-butyl hydroperoxide was tested. In all cases, benzaldehyde formed exclusively as the oxidation product...
- Novel polyaniline-supported molybdenum-catalyzed aerobic oxidation of alcohols to aldehydes and ketonesSubbarayan Velusamy
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India
Org Lett 6:4821-4. 2004..100 degrees C). The reactions of primary alcohols are faster compared to secondary alcohols and the catalyst 1 can be recycled without loss of activity...
- Assembly of [(eta5-C5Me5)MoS3Cu3]-supported one-dimensional chains with single, double, triple, and quadruple strandsWen Hua Zhang
School of Chemistry and Chemical Engineering, Suzhou University, Suzhou, Jiangsu, People s Republic of China
Inorg Chem 47:5332-46. 2008..In addition, the third-order nonlinear optical properties of 1a, 2, 3a, and 4-7 in aniline were also investigated by using the Z-scan technique with a 4.5 ns pulse laser at 532 nm...
- Reversible photoinduced magnetic properties in the heptanuclear complex [Mo(IV)(CN)(2)(CN--CuL)(6)](8+): a photomagnetic high-spin moleculeJuan Manuel Herrera
, CNRS, UMR 7071, , 75252 Paris Cedex 05, France
Angew Chem Int Ed Engl 43:5468-71. 2004
- RESPIRATORY ENDOTHELIAL INJURY BY XANTHINE OXIDASEJohn Repine; Fiscal Year: 2000..oxygen radical generating enzyme, aldehyde oxidase (AO) and discovered unanticipated genetic complexity in this molybdenum hydroxylase family which includes xanthine oxidase (XO)...
- CRYSTALLOGRAPHIC STUDIES OF ELECTRON TRANSFER PROTEINSDouglas Rees; Fiscal Year: 1993..Biological nitrogen fixation is catalyzed by the nitrogenase complex, which consists of iron (Fe-) protein and molybdenum iron (MoFe-) protein...
- BIOLOGICALLY RELATED IRON-SULFUR CHEMISTRYRICHARD HADLEY HOLM; Fiscal Year: 2010..directed at a detailed understanding of biologically relevant cluster clusters containing iron, sulfur, and molybdenum, vanadium, or nickel, various types of which are found at all levels of life...
- MOFE PROTEIN PROSTHETIC GROUPS IN NITROGENASE CATALYSISWILLIAM NEWTON; Fiscal Year: 2003..The proposed research centers on the molybdenum-iron protein of nitrogenase...
- METAL SULFUR & METAL CARBOXYLATE SITES IN REDOX ENZYMESDimitri Coucouvanis; Fiscal Year: 2001..for the Fe/M/S centers in the nitrogenases and alternate nitrogenases that contain vanadium or iron in place of molybdenum. The new types of Fe/S clusters that will be synthesized are designed as models for the P-clusters of ..
- Biosynthesis and Novel Function of Fe-S clustersBoi Hanh Huynh; Fiscal Year: 2007..important SAM-dependent enzyme, the human MOCS1A, which catalyzes the initial steps in the biosynthesis of molybdenum cofactor, MoCo...
- Low-Coordinate Synthetic Models for Nitrogenase ActivityPatrick L Holland; Fiscal Year: 2010..Recent spectroscopic work on iron- molybdenum nitrogenase strongly suggests that the mechanism involves binding of N2 to iron, and involves iron-hydride ..
- ROLE OF FEMO-COFACTOR IN NITROGENASE CATALYSISWILLIAM NEWTON; Fiscal Year: 1993..The proposed research is centered on the iron-molybdenum cofactor, the putative N2-binding site of nitrogenase, to determine how nitrogenase is organized to effect ..
- BIOSYNTHESES OF FEMO-CO AND FEV-CO OF NITROGENASEPAUL LUDDEN; Fiscal Year: 2007..At the active site of raj-encoded, molybdenum nitrogenase is the iron-molybdenum cofactor, FeMo-co...
- Environmental exposure to metal mixtures and kidney diseaseMary Fox; Fiscal Year: 2007..The metals are barium, cadmium, cobalt, lead, mercury, molybdenum, and uranium...
- THE BIOINORGANIC CHEMISTRY OF IRONAlison Butler; Fiscal Year: 2004..02-1 nM in surface seawater, whereas molybdenum and vanadium are the two most abundant transition metal ions at 100 nM and 20-35 nM, respectively...
- BIOLOGICALLY RELATED IRON-SULFUR CHEMISTRYRichard Holm; Fiscal Year: 2004..Research on more complex clusters, some of which contain heterometals such as molybdenum, vanadium, and nickel, is also emphasized...
- Nitrogenase Assembly and MechanismMarkus Ribbe; Fiscal Year: 2007..a complex metalloprotein composed of two separately purifiable protein components, the iron (Fe) protein and the molybdenum-iron (MoFe) protein, both of which containing metal cluster(s)...
- STRUCTURAL STUDIES ON EUKARYOTIC MOCO CONTAINING ENZYMESCaroline Kisker; Fiscal Year: 2003Enzymes containing the molybdenum cofactor catalyze important reactions in the global sulfur, nitrogen and carbon cycles and are currently classified into four different families...
- The Role of MgATP in Nitrogenase CatalysisJohn Peters; Fiscal Year: 2007..During nitrogenase catalysis, the iron protein and molybdenum-iron protein associate and dissociate in a manner resulting in the hydrolysis of two molecules of MgATP and the ..
- Molybdenum Pterin-Dithiolene Complexes for Model Studies of the Catalytic Site ofSHARON BURGMAYER; Fiscal Year: 2007The relationship of molybdenum to health is far less well known by the general public than that of familiar essential metals iron, copper and zinc...
- SPECTROSCOPIC STUDIES OF MOLYBDOENZYMES AND MODELSMartin Kirk; Fiscal Year: 2005..proposed in this project are directed toward developing a detailed electronic structure description pyranopterin molybdenum active sites, and how their unique electronic structures relate to their mechanism of activity...