molybdenum

Summary

Summary: A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.94. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase. (From Dorland, 27th ed)

Top Publications

  1. pmc Variation in molybdenum content across broadly distributed populations of Arabidopsis thaliana is controlled by a mitochondrial molybdenum transporter (MOT1)
    Ivan Baxter
    Bindley Bioscience Center, Purdue University, West Lafayette, Indiana, United States of America
    PLoS Genet 4:e1000004. 2008
  2. ncbi The prokaryotic complex iron-sulfur molybdoenzyme family
    Richard A Rothery
    Membrane Protein Research Group, Department of Biochemistry, 474 Medical Sciences Building, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Biochim Biophys Acta 1778:1897-929. 2008
  3. doi Biosynthesis of the iron-molybdenum cofactor of nitrogenase
    Luis M Rubio
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
    Annu Rev Microbiol 62:93-111. 2008
  4. doi van der Waals epitaxy of MoS₂ layers using graphene as growth templates
    Yumeng Shi
    Department of Electrical Engineering and Computer Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Nano Lett 12:2784-91. 2012
  5. doi Integrated circuits based on bilayer MoS₂ transistors
    Han Wang
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
    Nano Lett 12:4674-80. 2012
  6. ncbi Ethylbenzene dehydrogenase, a novel hydrocarbon-oxidizing molybdenum/iron-sulfur/heme enzyme
    O Kniemeyer
    , Celsiusstrasse 1, 28359 Bremen, Germany
    J Biol Chem 276:21381-6. 2001
  7. doi Essential metals for nitrogen fixation in a free-living N₂-fixing bacterium: chelation, homeostasis and high use efficiency
    J P Bellenger
    Department of Geosciences, PEI, Guyot Hall, Princeton University, Princeton, NJ 08544, USA
    Environ Microbiol 13:1395-411. 2011
  8. doi Synthesis of large-area MoS2 atomic layers with chemical vapor deposition
    Yi Hsien Lee
    Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan
    Adv Mater 24:2320-5. 2012
  9. pmc Hypersensitivity of Escherichia coli Delta(uvrB-bio) mutants to 6-hydroxylaminopurine and other base analogs is due to a defect in molybdenum cofactor biosynthesis
    S G Kozmin
    Department of Genetics, Sankt Petersburg State University, Saint Petersburg, Russia
    J Bacteriol 182:3361-7. 2000
  10. ncbi Exposure to chromium, cobalt and molybdenum from metal-on-metal total hip replacement and hip resurfacing arthroplasty
    Wolf Christoph Witzleb
    Department of Orthopaedic Surgery, Universty Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
    Acta Orthop 77:697-705. 2006

Research Grants

Detail Information

Publications348 found, 100 shown here

  1. pmc Variation in molybdenum content across broadly distributed populations of Arabidopsis thaliana is controlled by a mitochondrial molybdenum transporter (MOT1)
    Ivan Baxter
    Bindley Bioscience Center, Purdue University, West Lafayette, Indiana, United States of America
    PLoS Genet 4:e1000004. 2008
    b>Molybdenum (Mo) is an essential micronutrient for plants, serving as a cofactor for enzymes involved in nitrate assimilation, sulfite detoxification, abscisic acid biosynthesis, and purine degradation...
  2. ncbi The prokaryotic complex iron-sulfur molybdoenzyme family
    Richard A Rothery
    Membrane Protein Research Group, Department of Biochemistry, 474 Medical Sciences Building, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Biochim Biophys Acta 1778:1897-929. 2008
    ..We have used genome sequence data to establish that there is a bias against the presence of soluble periplasmic molybdoenzymes in bacteria lacking an outer membrane...
  3. doi Biosynthesis of the iron-molybdenum cofactor of nitrogenase
    Luis M Rubio
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
    Annu Rev Microbiol 62:93-111. 2008
    The iron-molybdenum cofactor (FeMo-co), located at the active site of the molybdenum nitrogenase, is one of the most complex metal cofactors known to date...
  4. doi van der Waals epitaxy of MoS₂ layers using graphene as growth templates
    Yumeng Shi
    Department of Electrical Engineering and Computer Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Nano Lett 12:2784-91. 2012
    ..The synthesized two-dimensional MoS(2)/Graphene hybrids possess great potential toward the development of new optical and electronic devices as well as a wide variety of newly synthesizable compounds for catalysts...
  5. doi Integrated circuits based on bilayer MoS₂ transistors
    Han Wang
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
    Nano Lett 12:4674-80. 2012
    Two-dimensional (2D) materials, such as molybdenum disulfide (MoS(2)), have been shown to exhibit excellent electrical and optical properties...
  6. ncbi Ethylbenzene dehydrogenase, a novel hydrocarbon-oxidizing molybdenum/iron-sulfur/heme enzyme
    O Kniemeyer
    , Celsiusstrasse 1, 28359 Bremen, Germany
    J Biol Chem 276:21381-6. 2001
    ..It is a novel molybdenum/iron-sulfur/heme protein of 155 kDa, which consists of three subunits (96, 43, and 23 kDa) in an alphabetagamma ..
  7. doi Essential metals for nitrogen fixation in a free-living N₂-fixing bacterium: chelation, homeostasis and high use efficiency
    J P Bellenger
    Department of Geosciences, PEI, Guyot Hall, Princeton University, Princeton, NJ 08544, USA
    Environ Microbiol 13:1395-411. 2011
    ..We conclude that A. vinelandii is well adapted to fix nitrogen in metal-limited soil environments...
  8. doi Synthesis of large-area MoS2 atomic layers with chemical vapor deposition
    Yi Hsien Lee
    Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan
    Adv Mater 24:2320-5. 2012
    ..Optical, microscopic and electrical measurements suggest that the synthetic process leads to the growth of MoS(2) monolayer. The TEM images verify that the synthesized MoS(2) sheets are highly crystalline...
  9. pmc Hypersensitivity of Escherichia coli Delta(uvrB-bio) mutants to 6-hydroxylaminopurine and other base analogs is due to a defect in molybdenum cofactor biosynthesis
    S G Kozmin
    Department of Genetics, Sankt Petersburg State University, Saint Petersburg, Russia
    J Bacteriol 182:3361-7. 2000
    ..The moeAB operon provides one of a large number of genes responsible for biosynthesis of the molybdenum cofactor...
  10. ncbi Exposure to chromium, cobalt and molybdenum from metal-on-metal total hip replacement and hip resurfacing arthroplasty
    Wolf Christoph Witzleb
    Department of Orthopaedic Surgery, Universty Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
    Acta Orthop 77:697-705. 2006
    ..This study was designed to investigate the serum concentration profiles of chromium, cobalt and molybdenum after implantation of a Birmingham hip resurfacing arthroplasty (BHR) and a cementless total hip replacement ..
  11. pmc Molecular characterization of the gene cluster coxMSL encoding the molybdenum-containing carbon monoxide dehydrogenase of Oligotropha carboxidovorans
    U Schübel
    Lehrstuhl fur Mikrobiologie, Universitat Bayreuth, Germany
    J Bacteriol 177:2197-203. 1995
    ..Sequence analysis suggested association of molybdopterin cytosine dinucleotide and flavin adenine dinucleotide with CoxL and of the [2Fe-2S] clusters with CoxS...
  12. doi A late methanogen origin for molybdenum-dependent nitrogenase
    E S Boyd
    Department of Chemistry and Biochemistry and the Astrobiology Biogeocatalysis Research Center, Montana State University, Bozeman, MT, USA
    Geobiology 9:221-32. 2011
    ..2.5-2.0 Ga). It has been suggested that the iron (Fe)- or vanadium (V)-dependent nitrogenase rather than molybdenum (Mo)-dependent form was responsible for dinitrogen fixation during this time because oceans were depleted in Mo ..
  13. doi Tracing the stepwise oxygenation of the Proterozoic ocean
    C Scott
    Department of Earth Sciences, University of California, Riverside, California 92521, USA
    Nature 452:456-9. 2008
    ..perspective on ocean oxygenation based on the authigenic accumulation of the redox-sensitive transition element molybdenum in sulphidic black shales...
  14. pmc Molybdoproteomes and evolution of molybdenum utilization
    Yan Zhang
    Department of Biochemistry, University of Nebraska, Lincoln, NE 68588 0664, USA
    J Mol Biol 379:881-99. 2008
    The trace element molybdenum (Mo) is utilized in many life forms, and it is a key component of several enzymes involved in nitrogen, sulfur, and carbon metabolism...
  15. doi Ambipolar MoS2 thin flake transistors
    Yijin Zhang
    Quantum Phase Electronics Center and Department of Applied Physics, The University of Tokyo, 7 3 1 Hongo, Tokyo 113 8656, Japan
    Nano Lett 12:1136-40. 2012
    ....
  16. ncbi Two crystal structures of the cytoplasmic molybdate-binding protein ModG suggest a novel cooperative binding mechanism and provide insights into ligand-binding specificity
    L Delarbre
    Department of Biological Chemistry, Norwich, NR4 7UH, UK
    J Mol Biol 308:1063-79. 2001
    ..two small beta-barrel domains, which display an OB-fold motif, also seen in the related structure of ModE, a molybdenum-dependent transcriptional regulator, and very recently in the Mop protein that, like ModG, has been implicated ..
  17. ncbi Influence of copper status on the accumulation of toxic and essential metals in cattle
    I Blanco-Penedo
    Universidade de Santiago de Compostela, Departamento de Patoloxia Animal, Facultade de Veterinaria, Lugo, Spain
    Environ Int 32:901-6. 2006
    ..Correlations between copper, toxic metals (cadmium, lead) and essential metals (molybdenum, iron, zinc, selenium, manganese and cobalt) concentrations were evaluated in liver and kidney of 195 calves ..
  18. doi Highly efficient electrocatalytic hydrogen production by MoS(x) grown on graphene-protected 3D Ni foams
    Yung Huang Chang
    Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan, ROC
    Adv Mater 25:756-60. 2013
    ..The superior performance of hydrogen evolution is attributed to the relatively high catalyst loading weight as well as its relatively low resistance...
  19. pmc Influence of sulfur deficiency on the expression of specific sulfate transporters and the distribution of sulfur, selenium, and molybdenum in wheat
    Fumie Shinmachi
    Rothamsted Research, West Common, Harpenden, Hertfordshire AL52JQ, United Kingdom
    Plant Physiol 153:327-36. 2010
    ..In 2008, S, sulfate, selenium (Se), and molybdenum (Mo) concentrations and sulfate transporter gene expression were analyzed throughout development...
  20. ncbi Molybdenum and tungsten in Campylobacter jejuni: their physiological role and identification of separate transporters regulated by a single ModE-like protein
    Michael E Taveirne
    Department of Microbiology, North Carolina State University, Raleigh, NC 27695, USA
    Mol Microbiol 74:758-71. 2009
    ..contains at least four enzymes predicted to contain a metal binding pterin (MPT), with the metal being either molybdenum or tungsten...
  21. ncbi Global gene expression analysis revealed an unsuspected deo operon under the control of molybdate sensor, ModE protein, in Escherichia coli
    Han Tao
    Department of Microbiology and Cell Science, University of Florida, Box 110700, Gainesville, FL 32611, USA
    Arch Microbiol 184:225-33. 2005
    ..This study identified additional targets, such as deo and opp, for the Mo-dependent control in E. coli...
  22. pmc Molybdenum and phosphorus interact to constrain asymbiotic nitrogen fixation in tropical forests
    Nina Wurzburger
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS ONE 7:e33710. 2012
    ..Phosphorus (P) is thought to limit N(2) fixation in many tropical soils, yet both molybdenum (Mo) and P are crucial for the nitrogenase reaction (which catalyzes N(2) conversion to ammonia) and cell growth...
  23. ncbi Molybdate transport and its effect on nitrogen utilization in the cyanobacterium Anabaena variabilis ATCC 29413
    Marta Zahalak
    Department of Biology, University of Missouri St Louis, 8001 Natural Bridge Road, St Louis, MO 63121 4499, USA
    Mol Microbiol 51:539-49. 2004
    b>Molybdenum is an essential component of the cofactors of many metalloenzymes including nitrate reductase and Mo-nitrogenase...
  24. doi Periplasmic nitrate reductase revisited: a sulfur atom completes the sixth coordination of the catalytic molybdenum
    Shabir Najmudin
    Departamento de Quimica, FCT UNL, REQUIMTE CQFB, Monte de Caparica, 2829 516, Almada, Portugal
    J Biol Inorg Chem 13:737-53. 2008
    ..electron paramagnetic resonance (EPR) studies in both catalytic and inhibiting conditions showed that the molybdenum center has high coordination flexibility when reacted with reducing agents, substrates or inhibitors...
  25. ncbi The involvement of molybdenum in life
    R J P Williams
    Inorganic Chemistry Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QR, United Kingdom
    Biochem Biophys Res Commun 292:293-9. 2002
    Quite extraordinarily molybdenum is an essential element in life for the uptake of nitrogen from both nitrogen gas and nitrate, yet it is a relatively rare heavy trace element...
  26. pmc Nitrogenase phylogeny and the molybdenum dependence of nitrogen fixation in Methanococcus maripaludis
    P S Kessler
    Department of Microbiology, University of Washington, Seattle 98195, USA
    J Bacteriol 179:541-3. 1997
    We studied the effects of molybdenum, vanadium, and tungsten on the diazotrophic growth of Methanococcus maripaludis. Mo stimulated growth, with a maximal response at 4.0 microM, while V had no effect at any concentration tested...
  27. pmc Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator
    Seiko Ishida
    Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA
    Cancer Cell 17:574-83. 2010
    ..Our results identify the copper transporter as a therapeutic target, which can be manipulated with copper chelating drugs to selectively enhance the benefits of platinum-containing chemotherapeutic agents...
  28. ncbi Maternal-foetal status of copper, iron, molybdenum, selenium and zinc in obese gestational diabetic pregnancies
    E Al-Saleh
    Department of Obstetrics and Gynecology Faculty of Medicine, University of Kuwait, P O Box 24923, Safat, 13110, Kuwait
    Acta Diabetol 44:106-13. 2007
    ..We conclude that obesity is not associated with significant alterations in antioxidant enzyme status in gestational diabetes and only with relatively minor alterations in status of some essential trace elements...
  29. ncbi Active site geometry and substrate recognition of the molybdenum hydroxylase quinoline 2-oxidoreductase
    Irena Bonin
    Abteilung für Strukturforschung, Max Planck Institut fur Biochemie, 82152 Martinsried, Germany
    Structure 12:1425-35. 2004
    ..Qor is a member of the molybdenum hydroxylases...
  30. pmc The molybdate-responsive Escherichia coli ModE transcriptional regulator coordinates periplasmic nitrate reductase (napFDAGHBC) operon expression with nitrate and molybdate availability
    Paul M McNicholas
    Department of Microbiology, University of California, Los Angeles, Los Angeles, California 90095 1489, USA
    J Bacteriol 184:3253-9. 2002
    ..The upstream ModE regulatory site functions to override nitrate control of napF gene expression when the essential enzyme component, molybdate, is limiting in the cell environment...
  31. ncbi Molybdenum and tungsten enzymes: the xanthine oxidase family
    Carlos D Brondino
    Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Campus Universitario, 3000 Santa Fe, Argentina
    Curr Opin Chem Biol 10:109-14. 2006
    Mononuclear molybdenum and tungsten are found in the active site of a diverse group of enzymes that, in general, catalyze oxygen atom transfer reactions...
  32. ncbi Catalytic reduction of dinitrogen to ammonia at a single molybdenum center
    Dmitry V Yandulov
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 301:76-8. 2003
    Dinitrogen (N2) was reduced to ammonia at room temperature and 1 atmosphere with molybdenum catalysts that contain tetradentate [HIPTN3N]3- triamidoamine ligands (such as [HIPTN3N]Mo(N2), where [HIPTN3N]3- is [(3,5-(2,4,6-i-Pr3C6H2)..
  33. ncbi A simplified method for inorganic phosphate determination and its application for phosphate analysis in enzyme assays
    Subhash D Katewa
    Department of Biochemistry, Faculty of Science, MS University of Baroda, Vadodara 390 002, India
    Anal Biochem 323:180-7. 2003
    ..hydrazine sulfate and ascorbic acid was used as the reducing agent and the conditions for the development of the molybdenum blue color were optimized. Thus in the 4.0 ml assay system, 0...
  34. ncbi Cobalt-chromium-molybdenum alloy causes metal accumulation and metallothionein up-regulation in rat liver and kidney
    Stig S Jakobsen
    Department of Neurobiology, Institute of Anatomy, University of Aarhus, Aarhus, Denmark
    Basic Clin Pharmacol Toxicol 101:441-6. 2007
    Cobalt-chromium-molybdenum (CoCrMo) metal-on-metal hip prosthesis has had a revival due to their excellent wear properties...
  35. ncbi A new type of metalloprotein: The Mo storage protein from azotobacter vinelandii contains a polynuclear molybdenum-oxide cluster
    Dirk Fenske
    Lehrstuhl fur Anorganische Chemie I, Universitat Bielefeld, Universitatsstrasse 25, 33615 Bielefeld, Germany
    Chembiochem 6:405-13. 2005
    ..The Mo storage protein is constitutively synthesized with respect to the nitrogen source and is regulated by molybdenum at an extremely low concentration level (0-50 nM)...
  36. ncbi Transport of molybdate in the cyanobacterium Anabaena variabilis ATCC 29413
    Teresa Thiel
    Department of Biology, University of Missouri St Louis, St Louis MO 63121, USA
    Arch Microbiol 179:50-6. 2002
    Heterocyst-forming filamentous cyanobacteria, such as Anabaena variabilis ATCC 29413, require molybdenum as a component of two essential cofactors for the enzymes nitrate reductase and nitrogenase. A...
  37. ncbi Nickel and molybdenum contact allergies in patients with coronary in-stent restenosis
    R Koster
    Department of Cardiology, University Hospital Eppendorf, Medical Clinic, Hamburg, Germany
    Lancet 356:1895-7. 2000
    Coronary in-stent restenosis might be triggered by contact allergy to nickel, chromate, or molybdenum ions released from stainless-steel stents...
  38. pmc A mutation in the gene for the neurotransmitter receptor-clustering protein gephyrin causes a novel form of molybdenum cofactor deficiency
    J Reiss
    Institut für Medizinische Physik und Biophysik der Universität Münster, D 48149 Munster, Germany
    Am J Hum Genet 68:208-13. 2001
    ..comparison revealed homologies between gephyrin and proteins necessary for the biosynthesis of the universal molybdenum cofactor (MoCo)...
  39. doi Identification of an Arabidopsis solute carrier critical for intracellular transport and inter-organ allocation of molybdate
    A Gasber
    Plant Physiology, Technical University of Kaiserslautern, Kaiserslautern, Germany
    Plant Biol (Stuttg) 13:710-8. 2011
    Plants represent an important source of molybdenum in the human diet. Recently, MOT1 has been identified as a transport protein responsible for molybdate import in Arabidopsis thaliana L...
  40. ncbi NarJ is a specific chaperone required for molybdenum cofactor assembly in nitrate reductase A of Escherichia coli
    F Blasco
    Laboratoire de Chimie Bacterienne, IBSM, CNRS, Marseilles, France
    Mol Microbiol 28:435-47. 1998
    ..Fluorescence, electron paramagnetic resonance (EPR) spectroscopy and molybdenum quantification based on inductively coupled plasma emission spectroscopy (ICPES) clearly indicate that, in the ..
  41. pmc A structure-based catalytic mechanism for the xanthine oxidase family of molybdenum enzymes
    R Huber
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Proc Natl Acad Sci U S A 93:8846-51. 1996
    The crystal structure of the xanthine oxidase-related molybdenum-iron protein aldehyde oxido-reductase from the sulfate reducing anaerobic Gram-negative bacterium Desulfovibrio gigas (Mop) was analyzed in its desulfo-, sulfo-, oxidized, ..
  42. ncbi The role of copper in tumour angiogenesis
    Sarah A Lowndes
    Cancer Research UK Medical Oncology Unit, The Churchill Hospital, Oxford OX3 7LJ, UK
    J Mammary Gland Biol Neoplasia 10:299-310. 2005
    ....
  43. ncbi The formylmethanofuran dehydrogenase isoenzymes in Methanobacterium wolfei and Methanobacterium thermoautotrophicum: induction of the molybdenum isoenzyme by molybdate and constitutive synthesis of the tungsten isoenzyme
    A Hochheimer
    Max Planck Institut fur terrestrische Mikrobiologie, Fachbereich Biologie, Philipps Universitat, Marburg, Germany
    Arch Microbiol 170:389-93. 1998
    ..thermoautotrophicum have been shown to contain two isoenzymes, a tungsten-containing isoenzyme (Fwd) and a molybdenum-containing isoenzyme (Fmd)...
  44. pmc The Drosophila molybdenum cofactor gene cinnamon is homologous to three Escherichia coli cofactor proteins and to the rat protein gephyrin
    K P Kamdar
    Department of Biology, Emory University, Atlanta, Georgia 30322
    Genetics 137:791-801. 1994
    Essentially all organisms depend upon molybdenum oxidoreductases which require a molybdopterin cofactor for catalytic activity...
  45. ncbi Tetrathiomolybdate protects against cardiac damage by doxorubicin in mice
    Guoqing Hou
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, 48109, USA
    J Lab Clin Med 146:299-303. 2005
    ..Our working hypothesis, based on the inhibition of interleukin-2 by tetrathiomolybdate as shown here, is that tetrathiomolybdate interrupts the inflammatory cascade at the activated-T-lymphocyte stage...
  46. ncbi Plasma molybdenum reflects dietary molybdenum intake
    Judith R Turnlund
    USDA ARS, Western Human Nutrition Research Center, University of California, Davis, CA 95616, USA
    J Nutr Biochem 15:90-5. 2004
    The relationship between plasma molybdenum (Mo) and dietary intake has not been investigated in humans. We developed an isotope dilution method to determine molybdenum in 0...
  47. doi Breakdown of high-performance monolayer MoS2 transistors
    Dominik Lembke
    Electrical Engineering Institute, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    ACS Nano 6:10070-5. 2012
    Two-dimensional (2D) materials such as monolayer molybdenum disulfide (MoS(2)) are extremely interesting for integration in nanoelectronic devices where they represent the ultimate limit of miniaturization in the vertical direction...
  48. pmc Molybdenum nitrogenase catalyzes the reduction and coupling of CO to form hydrocarbons
    Zhi Yong Yang
    Department of Chemistry and Biochemistry, Utah State University, Logan, Utah 84322, USA
    J Biol Chem 286:19417-21. 2011
    The molybdenum-dependent nitrogenase catalyzes the multi-electron reduction of protons and N(2) to yield H(2) and 2NH(3). It also catalyzes the reduction of a number of non-physiological doubly and triply bonded small molecules (e.g...
  49. pmc Metal trafficking for nitrogen fixation: NifQ donates molybdenum to NifEN/NifH for the biosynthesis of the nitrogenase FeMo-cofactor
    Jose A Hernandez
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 105:11679-84. 2008
    The molybdenum nitrogenase, present in a diverse group of bacteria and archea, is the major contributor to biological nitrogen fixation...
  50. pmc Algae and humans share a molybdate transporter
    Manuel Tejada-Jimenez
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad de Cordoba, Campus de Rabanales, Edif Severo Ochoa, 14071 Cordoba, Spain
    Proc Natl Acad Sci U S A 108:6420-5. 2011
    Almost all living organisms need to obtain molybdenum from the external medium to achieve essential processes for life...
  51. doi Interplay between size and crystal structure of molybdenum dioxide nanoparticles--synthesis, growth mechanism, and electrochemical performance
    Dorota Koziej
    Harvard University, School of Engineering and Applied Science, 29 Oxford Street, Cambridge, MA 02138, USA
    Small 7:377-87. 2011
    ..Is it shown that electrodes for lithium-ion batteries based on MoO(2) nanorods have a long-term cycling life. The specific discharge capacity even after 200 cycles at a discharge rate of 1 C is about 300 Ah kg(-1) ...
  52. pmc Copper chelation represses the vascular response to injury
    Lazar Mandinov
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough 04074, USA
    Proc Natl Acad Sci U S A 100:6700-5. 2003
    ....
  53. ncbi A whiff of oxygen before the great oxidation event?
    Ariel D Anbar
    School of Earth and Space Exploration, Arizona State University, Tempe, AZ 85287, USA
    Science 317:1903-6. 2007
    High-resolution chemostratigraphy reveals an episode of enrichment of the redox-sensitive transition metals molybdenum and rhenium in the late Archean Mount McRae Shale in Western Australia...
  54. pmc Molybdenum sequestration in Brassica species. A role for anthocyanins?
    K L Hale
    Department of Biology, Anatomy Zoology Building, Colorado State University, Fort Collins, Colorado 80523, USA
    Plant Physiol 126:1391-402. 2001
    To elucidate plant mechanisms involved in molybdenum (Mo) sequestration and tolerance, Brassica spp. seedlings were supplied with molybdate, and the effects on plant physiology, morphology, and biochemistry were analyzed...
  55. ncbi Direct analysis of molybdenum target generated x-ray spectra with a portable device
    S Stumbo
    Struttura Dipartimentale di Matematica e Fisica dell Università di Sassari, Sezione INEN di Cagliari, Italy
    Med Phys 31:2763-70. 2004
    ..The energy resolution has been determined using a calibrated x-ray source. Spectra were validated by comparison of the HVL measured using an ionization chamber...
  56. doi Cell biology of molybdenum in plants and humans
    Ralf R Mendel
    Institute of Plant Biology, Braunschweig University of Technology, 1 Humboldt Street, 38106 Braunschweig, Germany
    Biochim Biophys Acta 1823:1568-79. 2012
    The transition element molybdenum (Mo) needs to be complexed by a special cofactor in order to gain catalytic activity...
  57. pmc Extending the carbon chain: hydrocarbon formation catalyzed by vanadium/molybdenum nitrogenases
    Yilin Hu
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Science 333:753-5. 2011
    ..Additionally, we show that the more common molybdenum-dependent nitrogenase can generate the same hydrocarbons from CO, although CH(4) was not detected...
  58. pmc Biomimetic chemistry of iron, nickel, molybdenum, and tungsten in sulfur-ligated protein sites
    Stanislav Groysman
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Biochemistry 48:2310-20. 2009
    ..This account describes the current status of the synthetic analogue approach as applied to the mononuclear sites in certain molybdoenzymes and the polynuclear sites in hydrogenases, nitrogenase, and carbon monoxide dehydrogenases...
  59. ncbi Novel bacterial molybdenum and tungsten enzymes: three-dimensional structure, spectroscopy, and reaction mechanism
    Matthias Boll
    Institut fur Biologie II, Universitat Freiburg, Schänzlestr 1, D 79104 Freiburg, Germany
    Biol Chem 386:999-1006. 2005
    The molybdenum enzymes 4-hydroxybenzoyl-CoA reductase and pyrogallol-phloroglucinol transhydroxylase and the tungsten enzyme acetylene hydratase catalyze reductive dehydroxylation reactions, i.e...
  60. ncbi Characterization of the ModE DNA-binding sites in the control regions of modABCD and moaABCDE of Escherichia coli
    P M McNicholas
    Department of Microbiology and Molecular Genetics, University of California at Los Angeles 90095 1489, USA
    Mol Microbiol 23:515-24. 1997
    ..These findings demonstrate that ModE acts both as a repressor and activator of the mod and moa operons, respectively, depending on the properties of the binding site...
  61. pmc Molybdenum trafficking for nitrogen fixation
    Jose A Hernandez
    Department of Biochemistry, Midwestern University, Glendale, Arizona 85308, USA
    Biochemistry 48:9711-21. 2009
    The molybdenum nitrogenase is responsible for most biological nitrogen fixation, a prokaryotic metabolic process that determines the global biogeochemical cycles of nitrogen and carbon...
  62. ncbi Oxyanion binding alters conformation and quaternary structure of the c-terminal domain of the transcriptional regulator mode. Implications for molybdate-dependent regulation, signaling, storage, and transport
    D G Gourley
    Wellcome Trust Biocentre, University of Dundee, Dundee, DD1 5EH, United Kingdom
    J Biol Chem 276:20641-7. 2001
    ..and a regulator for the transcription of several operons that control the uptake and utilization of molybdenum. We present two high-resolution crystal structures of the C-terminal oxyanion-binding domain in complex with ..
  63. ncbi Impact of molybdenum on the copper status of red deer (Cervus elaphus)
    N D Grace
    AgResearch Limited, Grasslands Research Centre, Private Bag 11008, Palmerston North, New Zealand
    N Z Vet J 53:137-41. 2005
    To determine the effect of increasing molybdenum (Mo) intakes on serum and liver copper (Cu) concentrations and growth rates of grazing red deer (Cervus elaphus).
  64. doi Control of valley polarization in monolayer MoS2 by optical helicity
    Kin Fai Mak
    Department of Physics, Columbia University, 538 West 120th Street, New York, New York 10027, USA
    Nat Nanotechnol 7:494-8. 2012
    ..Our results, and similar results by Zeng et al., demonstrate the viability of optical valley control and suggest the possibility of valley-based electronic and optoelectronic applications in MoS(2) monolayers...
  65. ncbi Bioavailability of copper from copper glycinate in steers fed high dietary sulfur and molybdenum
    S L Hansen
    Department of Animal Science, North Carolina State University, Raleigh 27695, USA
    J Anim Sci 86:173-9. 2008
    ..Results of this study suggest that Cu from CuGly may be more available than CuSO(4) when supplemented to diets high in S and Mo...
  66. pmc Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikis
    Pawan Kumar
    Department of Otolaryngology Head and Neck Surgery and Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
    Mol Cancer 9:206. 2010
    ..However, very little is known about the effect of TM on tumor cell function and tumor metastasis. In this study, we explored the mechanisms underlying TM-mediated inhibition of tumor metastasis...
  67. ncbi Tetrathiomolybdate anticopper therapy for Wilson's disease inhibits angiogenesis, fibrosis and inflammation
    G J Brewer
    Department of Human Genetics and Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    J Cell Mol Med 7:11-20. 2003
    ..Most recently, it has been found that TM has antifibrotic and antiinflammatory effects through inhibition of profibrotic and proinflammatory cytokines...
  68. ncbi Functional characterization of the Bradyrhizobium japonicum modA and modB genes involved in molybdenum transport
    Maria J Delgado
    Departamento de Microbiologia del Suelo y Sistemas Simbioticos, Estacion Experimental del Zaidin, CSIC, PO Box 419, 18080 Granada, Spain
    Microbiology 152:199-207. 2006
    ..japonicum modA mutant grown in a medium without molybdate supplementation. These findings indicate that transcription of the B. japonicum modABC genes is repressed by molybdate...
  69. pmc Experimental copper deficiency, chromium deficiency and additional molybdenum supplementation in goats--pathological findings
    H Aupperle
    Institut für Veterinär Pathologie der Universität Leipzig, Leipzig, Germany
    Acta Vet Scand 42:311-21. 2001
    ..study shows that liver, pancreas and skin are mainly affected by a long term deficiency of copper and the findings are complicated by molybdenum application while chromium deficiency produced no histomorphological effects in our study.
  70. ncbi Tetrathiomolybdate causes formation of hepatic copper-molybdenum clusters in an animal model of Wilson's disease
    Graham N George
    Stanford Synchrotron Radiation Laboratory, Stanford Linear Accelerator Center, 2575 Sand Hill Road, MS 69, Menlo Park, California 94025, USA
    J Am Chem Soc 125:1704-5. 2003
    ..70 A. Each Cu is coordinated to 3-4 sulfurs at 2.28 A with approximately one Mo neighbor at 2.70 A. These results indicate the formation of a biologically novel molybdenum-copper-sulfur cluster.
  71. doi Tetrathiomolybdate induces doxorubicin sensitivity in resistant tumor cell lines
    Kyu Kwang Kim
    Molecular Therapeutics Laboratory, Program in Women s Oncology, Department of Obstetrics and Gynecology, Women and Infants Hospital, Alpert Medical School, Brown University, Providence, RI, USA
    Gynecol Oncol 122:183-9. 2011
    ..This study tests the hypothesis that TM can modulate antioxidants in tumor cells and render doxorubicin resistant tumor cells sensitive to doxorubicin...
  72. ncbi Caeruloplasmin: plasma copper ratios in cows
    S B Telfer
    Vet Rec 159:607-8; author reply 608. 2006
  73. doi Effects of molybdenum deficiency and defects in molybdate transporter MOT1 on transcript accumulation and nitrogen/sulphur metabolism in Arabidopsis thaliana
    Yoko Ide
    Biotechnology Research Center, University of Tokyo, 1 1 1, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Exp Bot 62:1483-97. 2011
    b>Molybdenum (Mo) is a micronutrient essential for plant growth, as several key enzymes of plant metabolic pathways contain Mo cofactor in their catalytic centres...
  74. pmc Highly efficient molybdenum-based catalysts for enantioselective alkene metathesis
    Steven J Malcolmson
    Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Nature 456:933-7. 2008
    ..The new catalysts have a stereogenic metal centre and carry only monodentate ligands; the molybdenum-based complexes are prepared stereoselectively by a ligand exchange process involving an enantiomerically pure ..
  75. doi A molybdenum complex bearing PNP-type pincer ligands leads to the catalytic reduction of dinitrogen into ammonia
    Kazuya Arashiba
    Institute of Engineering Innovation, School of Engineering, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 8656, Japan
    Nat Chem 3:120-5. 2011
    ..of ammonia being produced with the catalyst (12 equiv. of ammonia are produced based on the molybdenum atom of the catalyst)...
  76. doi Influence of soil properties on molybdenum uptake and elimination kinetics in the earthworm Eisenia andrei
    Maria Díez-Ortiz
    Department of Animal Ecology, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Chemosphere 80:1036-43. 2010
    This study aimed at determining the uptake and elimination kinetics of molybdenum in the earthworm Eisenia andrei, and the influence of soil properties on molybdenum bioaccumulation...
  77. ncbi Molybdenum-associated pituitary endocrinopathy in sheep treated with ammonium tetrathiomolybdate
    S Haywood
    Department of Veterinary Pathology, University of Liverpool, Liverpool L69 3BX, UK
    J Comp Pathol 130:21-31. 2004
    ..Excess molybdenum (Mo) retention (P<0...
  78. pmc Short- and long-term responses to molybdenum-99 shortages in nuclear medicine
    J R Ballinger
    Department of Nuclear Medicine, Guy s and St Thomas NHS Foundation Trust, and Division of Imaging Sciences and Biomedical Engineering, King s College London
    Br J Radiol 83:899-901. 2010
    ..In the long-term, stability of (99)Mo supply will rely on a combination of replacing conventional reactors and developing new technologies...
  79. ncbi Tetrathiomolybdate, a copper chelator for the treatment of Wilson disease, pulmonary fibrosis and other indications
    Valentina Medici
    University of California, Davis, Division of Gastroenterology and Hepatology, Department of Internal Med, 4150 V Street, Suite 3500, Sacramento, CA 95817, USA
    IDrugs 11:592-606. 2008
    ..TTM is predicted to most likely find a niche in the therapy of Wilson disease, for which current treatment options are limited...
  80. doi Antitumor activity of nifurtimox is enhanced with tetrathiomolybdate in medulloblastoma
    Karen S Koto
    Vermont Cancer Center, University of Vermont College of Medicine, Burlington, VT, USA
    Int J Oncol 38:1329-41. 2011
    ..Taken together, our results suggest nifurtimox and TM act synergistically in medulloblastoma cells in vitro, and that this combination warrants further studies as a new treatment for medulloblastoma...
  81. doi Trace elements status in diabetes mellitus type 2: possible role of the interaction between molybdenum and copper in the progress of typical complications
    Crescencio Rodríguez Flores
    Department of Chemistry, University of Guanajuato, 36000 Guanajuato, Mexico
    Diabetes Res Clin Pract 91:333-41. 2011
    ..In such approach, aluminum, vanadium, chromium, manganese, cobalt, nickel, copper, zinc, arsenic, selenium, molybdenum, mercury, cadmium and lead were determined by inductively coupled plasma-mass spectrometry (ICP-MS) in serum and ..
  82. doi Effect of tungsten and molybdenum on growth of a syntrophic coculture of Syntrophobacter fumaroxidans and Methanospirillum hungatei
    Caroline M Plugge
    Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB, Wageningen, The Netherlands
    Arch Microbiol 191:55-61. 2009
    The effect of tungsten (W) and molybdenum (Mo) on the growth of Syntrophobacter fumaroxidans and Methanospirillum hungatei was studied in syntrophic cultures and the pure cultures of both the organisms...
  83. pmc Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA
    Fertil Steril 93:130-40. 2010
    ..To explore associations between exposure to metals and male reproductive hormone levels...
  84. pmc Oxygen, nitrate, and molybdenum regulation of dmsABC gene expression in Escherichia coli
    P A Cotter
    Department of Microbiology, University of California, Los Angeles
    J Bacteriol 171:3817-23. 1989
    ..dmsA'-lacZ expression was also altered in chlD strains that are defective in molybdenum transport but not in chlA and chlE strains that are defective in molybdopterin cofactor biosynthesis, thus ..
  85. ncbi In vitro molybdenum ligation to molybdopterin using purified components
    Jason D Nichols
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:7817-22. 2005
    We have previously shown that Escherichia coli MoeA and MogA are required in vivo for the final step of molybdenum cofactor biosynthesis, the addition of the molybdenum atom to the dithiolene of molybdopterin...
  86. ncbi Crystallographic analysis of the MoFe protein of nitrogenase from a nifV mutant of Klebsiella pneumoniae identifies citrate as a ligand to the molybdenum of iron molybdenum cofactor (FeMoco)
    Suzanne M Mayer
    Department of Biological Chemistry, John Innes Centre, Norwich NR4 7UH, United Kingdom
    J Biol Chem 277:35263-6. 2002
    ..direct evidence that the organic acid citrate is not just present, but replaces homocitrate as a ligand to the molybdenum atom of the iron molybdenum cofactor (FeMoco)...
  87. ncbi Characterization of the NifS-like domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration
    Torsten Heidenreich
    Department of Plant Biology, Technical University of Braunschweig, 38023 Braunschweig, Germany
    J Biol Chem 280:4213-8. 2005
    The molybdenum cofactor sulfurase ABA3 from Arabidopsis thaliana specifically regulates the activity of the molybdenum enzymes aldehyde oxidase and xanthine dehydrogenase by converting their molybdenum cofactor from the desulfo-form into ..
  88. ncbi Structure and function of molybdopterin containing enzymes
    M J Romao
    Instituto de Tecnologia Quimica e Biologica, Oeiras, Portugal
    Prog Biophys Mol Biol 68:121-44. 1997
    ..In this review we give an account of the related spectroscopic information and the crystallographic results, with emphasis on structure-function studies...
  89. ncbi Biochemical and structural analysis of the molybdenum cofactor biosynthesis protein MobA
    Annika Guse
    Departments of Molecular Microbiology and Biological Chemistry, John Innes Centre, Norwich NR4 7UH, United Kingdom
    J Biol Chem 278:25302-7. 2003
    Molybdopterin guanine dinucleotide (MGD) is the form of the molybdenum cofactor that is required for the activity of most bacterial molybdoenzymes...
  90. ncbi Evidence for nifU and nifS participation in the biosynthesis of the iron-molybdenum cofactor of nitrogenase
    Dehua Zhao
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
    J Biol Chem 282:37016-25. 2007
    ..Although NifH contains a [4Fe-4S] cluster, the NifDK component carries two complex metalloclusters, the iron-molybdenum cofactor (FeMo-co) and the [8Fe-7S] P-cluster...
  91. pmc Coordination of selenium to molybdenum in formate dehydrogenase H from Escherichia coli
    V N Gladyshev
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 91:7708-11. 1994
    ..This ligand could be the Se of a selenocysteine residue, sulfur of a cysteine residue, or, in the case of a serine residue, oxygen...
  92. ncbi Electroanalytical determination of tungsten and molybdenum in proteins
    P L Hagedoorn
    Kluyver Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands
    Anal Biochem 297:71-8. 2001
    ..An electroanalytical tungsten determination has successfully been adapted to determine the tungsten and molybdenum content in enzymes...
  93. ncbi Tetrathiomolybdate therapy protects against bleomycin-induced pulmonary fibrosis in mice
    George J Brewer
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 0618, USA
    J Lab Clin Med 141:210-6. 2003
    ..The protection afforded by TM was also reflected in significantly reduced bleomycin-induced body-weight loss. In the next phase of this work, we will seek to determine the mechanisms by which TM brings about this therapeutic benefit...
  94. ncbi Syntheses, spectroscopies and structures of molybdenum(VI) complexes with homocitrate
    Zhao Hui Zhou
    Department of Chemistry, College of Chemistry and Chemical Engineering and State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen 361005, China
    Inorg Chem 45:8447-51. 2006
    Initial investigations into the possible role of homocitric acid in iron molybdenum cofactor (FeMo-co) of nitrogenase lead us to isolate and characterize two tetrameric molybdate(VI) species...
  95. ncbi Cloning, expression, and sequence analysis of the three genes encoding quinoline 2-oxidoreductase, a molybdenum-containing hydroxylase from Pseudomonas putida 86
    M Blase
    Institut für Mikrobiologie 250, Universitat Hohenheim, D 70593 Stuttgart, Germany
    J Biol Chem 271:23068-79. 1996
    ..putida KT2440 clone. The amino acid sequences of Qor show significant homology to various prokaryotic molybdenum containing hydroxylases and to eukaryotic xanthine dehydrogenases...
  96. pmc Cadmium, lead, and other metals in relation to semen quality: human evidence for molybdenum as a male reproductive toxicant
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Environ Health Perspect 116:1473-9. 2008
    ..g., zinc, copper) and nonessential (e.g., cadmium, lead), is inconsistent. Most studies to date used small sample sizes and were unable to account for important covariates...
  97. ncbi Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis
    Quintin Pan
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Res 62:4854-9. 2002
    ..Our study suggests that a major mechanism of the antiangiogenic effect of copper deficiency induced by TM is suppression of NFkappaB, contributing to a global inhibition of NFkappaB-mediated transcription of proangiogenic factors...
  98. pmc A widespread riboswitch candidate that controls bacterial genes involved in molybdenum cofactor and tungsten cofactor metabolism
    Elizabeth E Regulski
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Mol Microbiol 68:918-32. 2008
    We have identified a highly conserved RNA motif located upstream of genes encoding molybdate transporters, molybdenum cofactor (Moco) biosynthesis enzymes, and proteins that utilize Moco as a coenzyme...
  99. doi Molybdate transport through the plant sulfate transporter SHST1
    Kate L Fitzpatrick
    School of Agriculture, Food and Wine, The University of Adelaide, Waite Campus Urrbrae, SA 5064, Australia
    FEBS Lett 582:1508-13. 2008
    b>Molybdenum is an essential micronutrient required by plants. The mechanism of molybdenum uptake in plants is poorly understood, however, evidence has suggested that sulfate transporters may be involved...
  100. ncbi Phase II trial of tetrathiomolybdate in patients with advanced kidney cancer
    Bruce G Redman
    Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor 48109 0948, USA
    Clin Cancer Res 9:1666-72. 2003
    ..Tetrathiomolybdate (TM), a copper-lowering agent, has been shown in preclinical murine tumor models to be antiangiogenic. We evaluated the antitumor activity of TM in patients with advanced kidney cancer in a Phase II trial...
  101. ncbi Antiangiogenic tetrathiomolybdate enhances the efficacy of doxorubicin against breast carcinoma
    Quintin Pan
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Mol Cancer Ther 2:617-22. 2003
    ..4 +/- 14.3% greater than that in doxorubicin-treated mice. These results suggest that TM may enhance the rate of pathological complete response when used in combination with an anthracycline in neoadjuvant therapy of breast carcinoma...

Research Grants71

  1. RESPIRATORY ENDOTHELIAL INJURY BY XANTHINE OXIDASE
    John Repine; Fiscal Year: 2000
    ..oxygen radical generating enzyme, aldehyde oxidase (AO) and discovered unanticipated genetic complexity in this molybdenum hydroxylase family which includes xanthine oxidase (XO)...
  2. CRYSTALLOGRAPHIC STUDIES OF ELECTRON TRANSFER PROTEINS
    Douglas Rees; Fiscal Year: 1993
    ..Biological nitrogen fixation is catalyzed by the nitrogenase complex, which consists of iron (Fe-) protein and molybdenum iron (MoFe-) protein...
  3. BIOLOGICALLY RELATED IRON-SULFUR CHEMISTRY
    RICHARD HADLEY HOLM; Fiscal Year: 2010
    ..directed at a detailed understanding of biologically relevant cluster clusters containing iron, sulfur, and molybdenum, vanadium, or nickel, various types of which are found at all levels of life...
  4. MOFE PROTEIN PROSTHETIC GROUPS IN NITROGENASE CATALYSIS
    WILLIAM NEWTON; Fiscal Year: 2003
    ..The proposed research centers on the molybdenum-iron protein of nitrogenase...
  5. METAL SULFUR & METAL CARBOXYLATE SITES IN REDOX ENZYMES
    Dimitri Coucouvanis; Fiscal Year: 2001
    ..for the Fe/M/S centers in the nitrogenases and alternate nitrogenases that contain vanadium or iron in place of molybdenum. The new types of Fe/S clusters that will be synthesized are designed as models for the P-clusters of ..
  6. Biosynthesis and Novel Function of Fe-S clusters
    Boi Hanh Huynh; Fiscal Year: 2007
    ..important SAM-dependent enzyme, the human MOCS1A, which catalyzes the initial steps in the biosynthesis of molybdenum cofactor, MoCo...
  7. Low-Coordinate Synthetic Models for Nitrogenase Activity
    Patrick L Holland; Fiscal Year: 2010
    ..Recent spectroscopic work on iron- molybdenum nitrogenase strongly suggests that the mechanism involves binding of N2 to iron, and involves iron-hydride ..
  8. ROLE OF FEMO-COFACTOR IN NITROGENASE CATALYSIS
    WILLIAM NEWTON; Fiscal Year: 1993
    ..The proposed research is centered on the iron-molybdenum cofactor, the putative N2-binding site of nitrogenase, to determine how nitrogenase is organized to effect ..
  9. BIOSYNTHESES OF FEMO-CO AND FEV-CO OF NITROGENASE
    PAUL LUDDEN; Fiscal Year: 2007
    ..At the active site of raj-encoded, molybdenum nitrogenase is the iron-molybdenum cofactor, FeMo-co...
  10. Environmental exposure to metal mixtures and kidney disease
    Mary Fox; Fiscal Year: 2007
    ..The metals are barium, cadmium, cobalt, lead, mercury, molybdenum, and uranium...
  11. THE BIOINORGANIC CHEMISTRY OF IRON
    Alison Butler; Fiscal Year: 2004
    ..02-1 nM in surface seawater, whereas molybdenum and vanadium are the two most abundant transition metal ions at 100 nM and 20-35 nM, respectively...
  12. BIOLOGICALLY RELATED IRON-SULFUR CHEMISTRY
    Richard Holm; Fiscal Year: 2004
    ..Research on more complex clusters, some of which contain heterometals such as molybdenum, vanadium, and nickel, is also emphasized...
  13. Nitrogenase Assembly and Mechanism
    Markus Ribbe; Fiscal Year: 2007
    ..a complex metalloprotein composed of two separately purifiable protein components, the iron (Fe) protein and the molybdenum-iron (MoFe) protein, both of which containing metal cluster(s)...
  14. STRUCTURAL STUDIES ON EUKARYOTIC MOCO CONTAINING ENZYMES
    Caroline Kisker; Fiscal Year: 2003
    Enzymes containing the molybdenum cofactor catalyze important reactions in the global sulfur, nitrogen and carbon cycles and are currently classified into four different families...
  15. The Role of MgATP in Nitrogenase Catalysis
    John Peters; Fiscal Year: 2007
    ..During nitrogenase catalysis, the iron protein and molybdenum-iron protein associate and dissociate in a manner resulting in the hydrolysis of two molecules of MgATP and the ..
  16. Molybdenum Pterin-Dithiolene Complexes for Model Studies of the Catalytic Site of
    SHARON BURGMAYER; Fiscal Year: 2007
    The relationship of molybdenum to health is far less well known by the general public than that of familiar essential metals iron, copper and zinc...
  17. SPECTROSCOPIC STUDIES OF MOLYBDOENZYMES AND MODELS
    Martin Kirk; Fiscal Year: 2005
    ..proposed in this project are directed toward developing a detailed electronic structure description pyranopterin molybdenum active sites, and how their unique electronic structures relate to their mechanism of activity...