Genomes and Genes
Summary: A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.19, symbol Pb. (Dorland, 28th)
Publications247 found, 100 shown here
- Genotoxic effects of lead: an updated reviewJulia García-Lestón
Department Psychobiology, University of A Coruna, Edificio de Servicios Centrales de Investigación, A Coruna, Spain
Environ Int 36:623-36. 2010b>Lead is a ubiquitous toxic heavy metal with unique physical and chemical properties that make it suitable for a great variety of applications...
- Influence of prenatal lead exposure on genomic methylation of cord blood DNAJ Richard Pilsner
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
Environ Health Perspect 117:1466-71. 2009Fetal lead exposure is associated with adverse pregnancy outcomes and developmental and cognitive deficits; however, the mechanism(s) by which lead-induced toxicity occurs remains unknown...
- Low-level environmental lead exposure and intellectual impairment in children--the current concepts of risk assessmentMarek Jakubowski
Department of Chemical Safety, Nofer Institute of Occupational Medicine, Łódź, Poland
Int J Occup Med Environ Health 24:1-7. 2011b>Lead is an environmental contaminant. The majority of epidemiological research on the health effects of lead has been focused on children, because they are more vulnerable to lead than adults...
- Associations of early childhood manganese and lead coexposure with neurodevelopmentBirgit Claus Henn
Department of Environmental Health, Harvard School of Public Health, 401 Park Dr, Boston, MA 02215, USA
Environ Health Perspect 120:126-31. 2012..Most toxicologic studies focus on a single agent, although this does not reflect real-world scenarios in which humans are exposed to multiple chemicals...
- Study on clinical and biochemical toxicity biomarkers in a zinc-lead mine workersAli Akbar Malekirad
Science and Research Branch, Islamic Azad University IAU, Tehran, Iran
Toxicol Ind Health 26:331-7. 2010The aim of this study was to determine oxidative stress status as well as blood lead (Pb) and zinc (Zn) levels and clinical markers in workers of a Zn-Pb mine...
- Association of tobacco and lead exposures with attention-deficit/hyperactivity disorderTanya E Froehlich
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Pediatrics 124:e1054-63. 2009The study objective was to determine the independent and joint associations of prenatal tobacco and childhood lead exposures with attention-deficit/hyperactivity disorder (ADHD), as defined by current diagnostic criteria, in a national ..
- Childhood and adult socioeconomic position, cumulative lead levels, and pessimism in later life: the VA Normative Aging StudyJunenette L Peters
Department of Environmental Health, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
Am J Epidemiol 174:1345-53. 2011..There is evidence that individuals with higher lead exposure have poorer health...
- Renal and neurologic effects of cadmium, lead, mercury, and arsenic in children: evidence of early effects and multiple interactions at environmental exposure levelsClaire de Burbure
Unit of Industrial Toxicology and Occupational Medicine, Faculty of Medicine, Catholic University of Louvain, Clos Chapelle aux Champs 30, B 1200 Brussels, Belgium
Environ Health Perspect 114:584-90. 2006b>Lead, cadmium, mercury, and arsenic are common environmental pollutants in industrialized countries, but their combined impact on children's health is little known...
- Outbreak of fatal childhood lead poisoning related to artisanal gold mining in northwestern Nigeria, 2010Carrie A Dooyema
Healthy Homes and Lead Poisoning Prevention Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Environ Health Perspect 120:601-7. 2012In May 2010, a team of national and international organizations was assembled to investigate children's deaths due to lead poisoning in villages in northwestern Nigeria.
- Fibrillization of human tau is accelerated by exposure to lead via interaction with His-330 and His-362Hai Li Zhu
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
PLoS ONE 6:e25020. 2011..b>Lead is a potent neurotoxin for human being especially for the developing children, and Pb(2+) at high concentrations is ..
- Perinatal lead and mercury exposure in AustriaClaudia Gundacker
Institute of Medical Genetics, Medical University of Vienna, Währinger Strasse 10, 1090 Vienna, Austria
Sci Total Environ 408:5744-9. 2010The heavy metals lead (Pb) and mercury (Hg) are ubiquitous environmental pollutants with high neurotoxic potential...
- Developmental aspects of environmental neurotoxicology: lessons from lead and polychlorinated biphenylsGerhard Winneke
Division of Neurobehavioral Toxicology, Medical Institute of Environmental Hygiene, Heinrich Heine Universitat, Auf m Hennekamp 50, D 40225, Dusseldorf, Germany
J Neurol Sci 308:9-15. 2011..However, for only few of these, namely inorganic lead, arsenic, organic mercury and polychlorinated biphenyls (PCBs), human evidence is available to suggest that these ..
- Level of trace elements (copper, zinc, magnesium and selenium) and toxic elements (lead and mercury) in the hair and nail of children with autismMalarveni Damodaran Lakshmi Priya
Department of Biochemistry, Bharathi Women s College, Chennai, 600 108 Tamil Nadu, India
Biol Trace Elem Res 142:148-58. 2011..elements like copper (Cu), zinc (Zn), magnesium (Mg), and selenium (Se) and toxic elements like mercury (Hg), and lead (Pb) in the hair and nail samples of autistic children and to evaluate whether the level of these elements could be ..
- Association of blood lead (Pb) and plasma homocysteine: a cross sectional survey in Karachi, PakistanMohsin Yakub
Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
PLoS ONE 5:e11706. 2010High blood lead (Pb) and hyperhomocysteinemia have been found to be associated with cardiovascular disease (CVD). Mean blood Pb and mean plasma homocysteine levels have been reported to be high in Pakistani population...
- Relationship of thyroid hormone levels to levels of polychlorinated biphenyls, lead, p,p'- DDE, and other toxicants in Akwesasne Mohawk youthLawrence M Schell
Department of Anthropology, University at Albany, State University of New York, Albany, New York 12222, USA
Environ Health Perspect 116:806-13. 2008..Chronic exposure to multiple toxicants is common but difficult to analyze, and most prior studies have focused on adults or newborns, creating a gap in our understanding of multitoxicant effects among adolescents...
- Altered myelination and axonal integrity in adults with childhood lead exposure: a diffusion tensor imaging studyChristopher J Brubaker
Cincinnati Children s Environmental Health Center at the Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Neurotoxicology 30:867-75. 2009Childhood lead exposure is associated with adverse cognitive, neurobehavioral and motor outcomes, suggesting altered brain structure and function...
- Blood cadmium and lead and chronic kidney disease in US adults: a joint analysisAna Navas-Acien
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Am J Epidemiol 170:1156-64. 2009Environmental cadmium and lead exposures are widespread, and both metals are nephrotoxic at high exposure levels...
- Pseudo-second-order model for lead ion sorption from aqueous solutions onto palm kernel fiberYuh Shan Ho
Department of Environmental Sciences, College of Environmental Sciences, Peking University, Beijing 100871, People s Republic of China
J Hazard Mater 129:137-42. 2006The sorption of lead ion onto palm kernel fiber was studied by performing batch kinetic sorption experiments...
- Environmental tobacco smoke (ETS) exposure in children with asthma-relation between lead and cadmium, and cotinine concentrations in urineStefan Willers
Unit of Preventive Medicine, Heart and Lung Center, Lund University Hospital, SE 221 85 Lund, Sweden
Respir Med 99:1521-7. 2005..The corresponding concentrations of the heavy metals cadmium and lead in dust and urine (U-Cd; U-Pb) were determined in the same samples...
- LeadDavid C Bellinger
Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
Pediatrics 113:1016-22. 2004Children differ from adults in the relative importance of lead sources and pathways, lead metabolism, and the toxicities expressed. The central nervous system effects of lead on children seem not to be reversible...
- Exposure to arsenic and lead and neuropsychological development in Mexican childrenJ Calderon
Facultad de Medicina, Universidad Autonoma de San Luis Potosi, Av Venustiano Carranza 2405, 78210 San Luis Potosi, Mexico
Environ Res 85:69-76. 2001This cross-sectional study examined the effects of chronic exposure to lead (Pb), arsenic (AS) and undernutrition on the neuropsychological development of children...
- Fetal growth restriction is related to placental levels of cadmium, lead and arsenic but not with antioxidant activitiesMiguel N Llanos
Laboratory of Nutrition and Metabolic Regulation, Institute of Nutrition and Food Technology INTA, University of Chile, Macul 5540, Casilla 138 11, Santiago, Chile
Reprod Toxicol 27:88-92. 2009..and arsenic were measured by Instrumental Neutron Activation Analysis (INAA), and iron, copper, cadmium and lead by Atomic Absorption Spectrometry (AAS)...
- Trends in blood lead levels and blood lead testing among US children aged 1 to 5 years, 1988-2004Robert L Jones
Centers for Disease Control and Prevention, National Center for Environmental Health, 4770 Buford Hwy, Atlanta, GA 30341
Pediatrics 123:e376-85. 2009To evaluate trends in children's blood lead levels and the extent of blood lead testing of children at risk for lead poisoning from national surveys conducted during a 16-year period in the United States.
- Mechanisms of lead-induced hypertension and cardiovascular diseaseNosratola D Vaziri
Division of Nephrology and Hypertension, UCI Medical Center, 101 The City Dr, Bldg 53, Rm 125, Rt 81, Orange, CA 92868, USA
Am J Physiol Heart Circ Physiol 295:H454-65. 2008b>Lead is a ubiquitous environmental toxin that is capable of causing numerous acute and chronic illnesses...
- Low-level environmental lead exposure and children's intellectual function: an international pooled analysisBruce P Lanphear
Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Environ Health Perspect 113:894-9. 2005b>Lead is a confirmed neurotoxin, but questions remain about lead-associated intellectual deficits at blood lead levels < 10 microg/dL and whether lower exposures are, for a given change in exposure, associated with greater deficits...
- Co-exposure to environmental lead and manganese affects the intelligence of school-aged childrenYeni Kim
Division of Child and Adolescent Psychiatry, Department of Psychiatry and Institute of Human Behavioral Medicine, Seoul National University College of Medicine, 28 YeonGun Dong, Chongno Gu, Seoul, 110 744, Republic of Korea
Neurotoxicology 30:564-71. 2009Exposure to environmental levels of lead (Pb) and manganese (Mn) has been associated with detrimental effects to neurodevelopment...
- Very low lead exposures and children's neurodevelopmentDavid C Bellinger
Children s Hospital Boston, Harvard Medical School, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Curr Opin Pediatr 20:172-7. 2008We remain far from achieving the goal of eliminating lead-associated neurodevelopmental morbidities in children...
- Suppression of Chlorella vulgaris growth by cadmium, lead, and copper stress and its restoration by endogenous brassinolideAndrzej Bajguz
Department of Plant Biochemistry and Toxicology, Institute of Biology, University of Bialystok, Swierkowa 20 B, 15 950 Bialystok, Poland
Arch Environ Contam Toxicol 60:406-16. 2011..vulgaris cultures treated with 10(-8) M brassinolide (BL) were exposed to 10(-6)-10(-4) M heavy metals (cadmium, lead and copper) application...
- Exposure to Pb, Cd, and As mixtures potentiates the production of oxidative stress precursors: 30-day, 90-day, and 180-day drinking water studies in ratsMargaret H Whittaker
Toxicology Program, The University of Maryland at Baltimore, Baltimore, MD, USA
Toxicol Appl Pharmacol 254:154-66. 2011..Interactive effects of lead (Pb), cadmium (Cd) and arsenic (As) were evaluated in 30-, 90-, and 180-day factorial design drinking water studies ..
- Heavy metals (lead, cadmium and mercury) in maternal, cord blood and placenta of healthy womenIman Al-Saleh
Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia
Int J Hyg Environ Health 214:79-101. 2011b>Lead, cadmium and mercury were measured in placental tissue, umbilical cord and maternal blood samples of 1578 women who delivered at the Al-Kharj King Khalid Hospital between 2005 and 2006...
- Heavy metals exposure and hearing loss in US adolescentsJosef Shargorodsky
Channing Laboratory, 181 Longwood Ave, Boston, MA 02115, USA
Arch Otolaryngol Head Neck Surg 137:1183-9. 2011..Hearing loss is common and, in young persons, can compromise social development and educational achievement. Exposure to heavy metals has been proposed as an important risk factor for hearing loss...
- The relation of lead neurotoxicity to the event-related potential P3b component in Inuit children from arctic QuébecOlivier Boucher
Ecole de Psychologie, Universite Laval, Quebec, Canada
Neurotoxicology 30:1070-7. 2009..in many experimental paradigms, was measured in Inuit children from Nunavik (Arctic Québec, Canada) to assess lead (Pb) neurotoxicity...
- Nephrotoxicity of cadmium & leadH C Gonick
Division of Nephrology, West Los Angeles Healthcare Center, Los Angeles, California 90073, USA
Indian J Med Res 128:335-52. 2008Cadmium and lead are divalent cations with a propensity to settle in the proximal tubule of the nephron, leading to nephrotoxicity. The pathophysiological results, however, tend to diverge...
- Longitudinal associations between blood lead concentrations lower than 10 microg/dL and neurobehavioral development in environmentally exposed children in Mexico CityMartha M Téllez-Rojo
Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
Pediatrics 118:e323-30. 2006..that 10 microg/dL, the current Centers for Disease Control and Prevention screening guideline for children's blood lead level, should not be interpreted as a level at which adverse effects do not occur...
- Lead exposure and cardiovascular disease--a systematic reviewAna Navas-Acien
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Environ Health Perspect 115:472-82. 2007This systematic review evaluates the evidence on the association between lead exposure and cardiovascular end points in human populations.
- A population-based assessment of blood lead levels in relation to inflammationNatthapol Songdej
Department of Community and Preventive Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Environ Res 110:272-7. 2010Some experimental and observational research suggests that inflammation may be an important mediator of lead toxicity. However, lead-induced inflammation has not been well-studied in non-occupationally exposed populations.
- Cellular mechanisms of lead neurotoxicityAnibal Garza
Instituto de Fisiologia, Universidad Autonoma de Puebla, Pue, Mexico
Med Sci Monit 12:RA57-65. 2006b>Lead (Pb2+), a heavy metal, has been used by humans for many technological purposes, which is the main reason for its present widespread distribution...
- Metallothioneins are required for formation of cross-adaptation response to neurobehavioral toxicity from lead and mercury exposure in nematodesBoping Ye
College of Life Science and Technology, China Pharmaceutical University, Nanjing, China
PLoS ONE 5:e14052. 2010..Therefore, the normal formation of cross-adaptation response to neurobehavioral toxicity induced by metal exposure may need the enough accumulation of MTs protein in animal tissues...
- Molecular neurobiology of lead (Pb(2+)): effects on synaptic functionApril P Neal
Department of Pharmacology and Toxicology, Michigan State University, B307 Life Sciences Building, East Lansing, MI 48824, USA
Mol Neurobiol 42:151-60. 2010b>Lead (Pb(2+)) is a ubiquitous environmental neurotoxicant that continues to threaten public health on a global scale. Epidemiological studies have demonstrated detrimental effects of Pb(2+) on childhood IQ at very low levels of exposure...
- A critical review of biomarkers used for monitoring human exposure to lead: advantages, limitations, and future needsFernando Barbosa
Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
Environ Health Perspect 113:1669-74. 2005b>Lead concentration in whole blood (BPb) is the primary biomarker used to monitor exposure to this metallic element. The U.S. Centers for Disease Control and Prevention and the World Health Organization define a BPb of 10 microg/dL (0...
- Potentially toxic metal contamination of urban soils and roadside dust in Shanghai, ChinaGuitao Shi
Key Laboratory of Geographic Information Science of Ministry of Education, East China Normal University, Shanghai 200062, China
Environ Pollut 156:251-60. 2008....
- The detoxification of lead in Sedum alfredii H. is not related to phytochelatins but the glutathioneD K Gupta
Ministry of Education Key Laboratory of Environmental Remediation and Ecosystem Health, Zhejiang University, Hua jian chi Campus, Hangzhou 310029, China
J Hazard Mater 177:437-44. 2010..These results suggest that enzymatic and non-enzymatic antioxidants play a key role in the detoxification of Pb-induced toxic effects in Sedum alfredii. This plant can be used as an indicator species for Pb contamination...
- Lead-induced oxidative stress adversely affects health of the occupational workersD A Khan
Department of Pathology Army Medical College, National University Sciences and Technology, Rawalpindi, Pakistan
Toxicol Ind Health 24:611-8. 2008b>Lead is a persistent toxic metal and associated with impairment of various body functions in occupational workers...
- Monitoring of lead, cadmium, chromium and nickel in placenta from an e-waste recycling town in ChinaYongyong Guo
Analytical Cytology Laboratory, Shantou University Medical College, Guangdong, P R China
Sci Total Environ 408:3113-7. 2010..from unregulated electronic waste (e-waste) recycling in Guiyu, China, and thus may contribute to the elevation of lead and other heavy metals levels in placenta...
- Effects of lead exposure on oxidative stress biomarkers and plasma biochemistry in waterbirds in the fieldMonica Martinez-Haro
Instituto de Investigación en Recursos Cinegéticos CSIC UCLM JCCM, Ronda de Toledo s n, 13071 Ciudad Real, Spain
Environ Res 111:530-8. 2011Medina lagoon in Andalusia has one of the highest densities of spent lead (Pb) shot in Europe...
- Lead and bisphenol A concentrations in the Canadian populationTracey Bushnik
Health Analysis Division, Statistics Canada, Ottawa, Ontario K1A0T6
Health Rep 21:7-18. 2010b>Lead is a known toxicant that occurs naturally in the environment. Bisphenol A (BPA) is an industrial chemical used primarily in polycarbonate plastic and epoxy resins...
- The influence of age of lead exposure on adult gray matter volumeChristopher J Brubaker
Cincinnati Children s Environmental Health Center, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Neurotoxicology 31:259-66. 2010Childhood lead exposure is associated with decreased cognitive abilities and executive functioning localized within the prefrontal cortex...
- Lead exposure: a contributing cause of the current breast cancer epidemic in Nigerian womenOlusegun I Alatise
Department of Anatomy and Cell Biology, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Nigeria
Biol Trace Elem Res 136:127-39. 2010..This suggested that the associated widespread contamination of the soil and of the water supplies by lead (Pb) and other industrial metals was a major contributing cause...
- Bone lead levels and blood pressure endpoints: a meta-analysisAna Navas-Acien
Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
Epidemiology 19:496-504. 2008Previous reviews have shown increases in blood pressure and hypertension associated with increases in lead levels in blood...
- The effect of long-term low-dose lead exposure on thyroid function in adolescentsBumin Dundar
Department of Pediatrics, Faculty of Medicine, Suleyman Demirel University, Merkez 32040, Isparta, Turkey
Environ Res 101:140-5. 2006This study investigated blood lead (Pb-B) levels and Pb-B effects on thyroid functions in long-term low-level-lead-exposed male adolescents who work as auto repairers...
- Lead, zinc, cadmium, mercury, selenium and copper in Greenland caribou and reindeer (Rangifer tarandus)P Aastrup
Department of Arctic Environment, National Environmental Research Institute, Copenhagen, Denmark
Sci Total Environ 245:149-59. 2000..The levels of lead, zinc, cadmium, mercury, selenium, and copper were determined, and analyzed in relation to location, two seasons, ..
- Lead in pharmaceutical products and dietary supplementsJohn F Kauffman
U S Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Sciences, Division of Pharmaceutical Analysis, 1114 Market St, St Louis, MO 63101, USA
Regul Toxicol Pharmacol 48:128-34. 2007The objective of this study is to determine lead concentrations in a variety of widely used pharmaceutical products, and to assess the risk of lead exposure from using these products...
- New and evolving concepts in the neurotoxicology of leadL D White
National Center for Environmental Assessment, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Appl Pharmacol 225:1-27. 2007b>Lead (Pb) is a xenobiotic metal with no known essential function in cellular growth, proliferation, or signaling...
- Lead induced oxidative damage and its response to combined administration of alpha-lipoic acid and succimers in ratsManisha Pande
Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior, India
Toxicology 177:187-96. 2002..acid (LA) has been reported to be highly effective in improving the thiol capacity of the cells and in reducing lead induced oxidative stress...
- VolSurf: a new tool for the pharmacokinetic optimization of lead compoundsG Cruciani
Laboratory for Chemometrics, University of Perugia, Via Elce di Sotto 10, I 06123 Perugia, Italy
Eur J Pharm Sci 11:S29-39. 2000..The method thus appears as a valuable new property filter in virtual screening and as a novel tool in optimizing the pharmacokinetic profile of pharmaceutically relevant compounds...
- Low blood levels of lead and mercury and symptoms of attention deficit hyperactivity in children: a report of the children's health and environment research (CHEER)Mina Ha
Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea
Neurotoxicology 30:31-6. 2009The goal of this study was to examine the association between low levels of lead and mercury in blood and symptoms of attention-deficit hyperactivity disorder (ADHD) among Korean children.
- Environmental exposure to lead, but not other neurotoxic metals, relates to core elements of ADHD in Romanian children: performance and questionnaire dataRodica Nicolescu
Institutul de Sănătate Publică, Str Dr Leonte 1 3, 050463 Bucuresti, Romania
Environ Res 110:476-83. 2010..features of the attention-deficit hyperactivity disorder (ADHD) have been studied in pediatric environmental lead research...
- Lead and PCBs as risk factors for attention deficit/hyperactivity disorderPaul A Eubig
Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
Environ Health Perspect 118:1654-67. 2010..In this review we present evidence that environmental chemicals, particularly polychlorinated biphenyls (PCBs) and lead, are associated with deficits in many neurobehavioral functions that are also impaired in ADHD.
- Childhood lead exposure in France: benefit estimation and partial cost-benefit analysis of lead hazard controlCéline Pichery
EHESP School of Public Health, CS 74312 35043 Rennes Cedex, France
Environ Health 10:44. 2011b>Lead exposure remains a public health concern due to its serious adverse effects, such as cognitive and behavioral impairment: children younger than six years of age being the most vulnerable population...
- Mass lead intoxication from informal used lead-acid battery recycling in dakar, senegalPascal Haefliger
Department of Public Health and Environment, World Health Organization, Geneva, Switzerland
Environ Health Perspect 117:1535-40. 2009..died from a rapidly progressive central nervous system disease of unexplained origin in a community involved in the recycling of used lead-acid batteries (ULAB) in the suburbs of Dakar, Senegal. We investigated the cause of these deaths.
- Environmental lead exposure and progressive renal insufficiencyJ L Lin
Poison Center and Division of Nephrology, Chang Gung Memorial Hospital, 199, Tung Hwa North Road, Taipei, Taiwan, Republic of China
Arch Intern Med 161:264-71. 2001Several recent studies show that serum creatinine level or creatinine clearance is inversely associated with blood lead levels. However, the studies did not allow direct inferences about causality.
- Cross-sectional study of blood lead effects on iron status in Korean lead workersHee Seon Kim
Department of Food Science and Nutrition, Soonchunhyang University, Asan, South Korea
Nutrition 19:571-6. 2003This study assessed the iron status of Korean male lead workers by measuring the dietary iron intake and biochemical indices, and tested the hypothesis that a high blood lead level is associated with impaired iron function, which results ..
- Biomarkers of lead exposure and DNA methylation within retrotransposonsRobert O Wright
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 118:790-5. 2010..Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a marker of cumulative exposure, may therefore better predict DNA methylation than does blood lead.
- Impact of lead exposure on pituitary-thyroid axis in humansB Singh
Department of Nuclear Medicine, PGIMER 160 012, Chandigarh, India
Biometals 13:187-92. 2000..7 +/- 10.6 years; mean duration of lead exposure: 156.9 +/- 122.7 months)...
- Microarray analysis of differential gene expression in lead-exposed astrocytesC M Bouton
Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland 21205, USA
Toxicol Appl Pharmacol 176:34-53. 2001The toxic metal lead is a widespread environmental health hazard that can adversely affect human health...
- Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for ADJinfang Wu
Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island 02881, USA
J Neurosci 28:3-9. 2008..Recent studies in rodents have shown that exposure to lead (Pb) during brain development predetermined the expression and regulation of the amyloid precursor protein (APP) ..
- Environmental lead exposure and progression of chronic renal diseases in patients without diabetesJa Liang Lin
Division of Nephrology, Chang Gung Memorial Hospital, Lin Kou Medical Center, Medical College of Chang Gung University, Taipei, Taiwan
N Engl J Med 348:277-86. 2003Previous research suggests that environmental lead exposure correlates with age-related decreases in renal function.
- Lead neurotoxicity and socioeconomic status: conceptual and analytical issuesDavid C Bellinger
Children s Hospital Boston, Farley Basement Box 127, Harvard Medical School, Harvard School of Public Health, 300 Longwood Avenue, Boston, MA 02115, United States
Neurotoxicology 29:828-32. 2008Socioeconomic status (SES) is usually considered to be a potential confounder of the association between lead exposure and children's neurodevelopment, but experimental and epidemiological data suggest that SES might also modify lead ..
- The relation of environmental contaminants exposure to behavioral indicators in Inuit preschoolers in Arctic QuebecP Plusquellec
CHUQ Research Center, Quebec, QC, Canada
Neurotoxicology 31:17-25. 2010Although lead (Pb) exposure has been identified as an important risk factor in child behavioral development, less is known regarding the relation between child behavior and exposure to polychlorinated biphenyls (PCBs) and mercury (Hg)...
- AtHMA3, a P1B-ATPase allowing Cd/Zn/Co/Pb vacuolar storage in ArabidopsisMelanie Morel
l Energie Atomique, DSV, IBEB, Lab Echanges Membran and Signalisation, Saint Paul lez Durance F 13108, France
Plant Physiol 149:894-904. 2009..cerevisiae, that in the presence of toxic metals, AtHMA3 was able to phenotypically complement the cadmium/lead (Cd/Pb)-hypersensitive strain ycf1 but not the zinc (Zn)-hypersensitive strain zrc1...
- Association of prenatal and childhood blood lead concentrations with criminal arrests in early adulthoodJohn Paul Wright
Cincinnati Children s Environmental Health Center, Division of Criminal Justice, University of Cincinnati, Cincinnati, Ohio, United States of America
PLoS Med 5:e101. 2008Childhood lead exposure is a purported risk factor for antisocial behavior, but prior studies either relied on indirect measures of exposure or did not follow participants into adulthood to examine the relationship between lead exposure ..
- Decreased brain volume in adults with childhood lead exposureKim M Cecil
Cincinnati Children s Environmental Health Center, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
PLoS Med 5:e112. 2008Although environmental lead exposure is associated with significant deficits in cognition, executive functions, social behaviors, and motor abilities, the neuroanatomical basis for these impairments remains poorly understood...
- Blood lead at currently acceptable levels may cause preterm labourMohsen Vigeh
National Institute of Occupational Safety and Health, 6 21 6 Nagao, Tama ku, Kawasaki 214 8585, Japan
Occup Environ Med 68:231-4. 2011Although occupational and environmental exposures to lead have been dramatically reduced in recent decades, adverse pregnancy outcomes have been observed at 'acceptable' levels of blood lead concentrations (≤ 10 μg/dl).
- Environmental lead after Hurricane Katrina: implications for future populationsFelicia A Rabito
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal St, SL18, Room 2016, New Orleans, LA 70112, USA
Environ Health Perspect 120:180-4. 2012..Researchers have identified the potential for increased lead hazards from environmental lead contamination of soils...
- Integrating susceptibility into environmental policy: an analysis of the national ambient air quality standard for leadRamya Chari
RAND Corporation, 1200 South Hayes Street, Arlington, VA 22202, USA
Int J Environ Res Public Health 9:1077-96. 2012..S. Environmental Protection Agency (EPA) to set a National Ambient Air Quality Standard (NAAQS) for lead. To determine a NAAQS, EPA estimated air lead-related decreases in child neurocognitive function through a ..
- Correlations of gene expression with blood lead levels in children with autism compared to typically developing controlsYingfang Tian
Department of Neurology, University of California at Davis, Sacramento, CA 95817, USA
Neurotox Res 19:1-13. 2011The objective of this study was to examine the correlation between gene expression and lead (Pb) levels in blood in children with autism (AU, n = 37) compared to typically developing controls (TD, n = 15)...
- Perinatal lead exposure affects nitric oxide and cyclooxygenase pathways in aorta of weaned ratsLarissa Tercilia Grizzo
Departamento de Farmacologia, Instituto de Biociencias, Sao Paulo State University UNESP, Distrito de Rubiao Junior S N, 18618 000 Botucatu, SP, Brazil
Toxicol Sci 103:207-14. 2008..Blood lead concentration and systolic blood pressure (SBP) were higher in intoxicated than control pups (blood lead microg/dl: ..
- Iron fortification reduces blood lead levels in children in Bangalore, IndiaMichael B Zimmermann
Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland
Pediatrics 117:2014-21. 2006Chronic lead poisoning and iron deficiency are concentrated in urban children from lower socioeconomic strata, and both impair neurocognitive development...
- Probabilistic modeling of young children's overall lead exposure in France: integrated approach for various exposure mediaPhilippe Glorennec
National School of Public Health, avenue du professeur Leon Bernard, 35043 Rennes Cedex, France
Environ Int 33:937-45. 2007Emissions of lead into the environment (and thus its environmental concentrations) have decreased in recent years...
- Determination of arsenic, cadmium, mercury, and lead by inductively coupled plasma/mass spectrometry in foods after pressure digestion: NMKL interlaboratory studyKaare Julshamn
National Institute of Nutrition and Seafood Research NIFES, PO Box 2029 Nordnes, N 5817 Bergen, Norway
J AOAC Int 90:844-56. 2007..method performance (collaborative) study on a method for the determination of arsenic, cadmium, mercury, and lead by inductively coupled plasma/mass spectrometry (ICP/MS) after pressure digestion including the microwave heating ..
- Neoplastic transformation of human bronchial cells by lead chromate particlesHong Xie
Wise Laboratory of Environmental and Genetic Toxicology, University of Southern Maine, Portland, Maine 04104, USA
Am J Respir Cell Mol Biol 37:544-52. 2007..We found that aneuploid cells increased in a concentration-dependent manner after chronic exposure to lead chromate. Moreover, chronic exposure to lead chromate induced BEP2D cell transformation...
- Stress as a potential modifier of the impact of lead levels on blood pressure: the normative aging studyJunenette L Peters
Department of Environmental Health, Harvard Shool of Public Health, Boston, MA 02215, USA
Environ Health Perspect 115:1154-9. 2007b>Lead exposure and psychological stress have been independently associated with hypertension in various populations, and animal studies suggest that when they co-occur, their effects may be exacerbated.
- Assessing the risk of lead exposure for the conservation of the endangered Pyrenean bearded vulture (Gypaetus barbatus) populationMauro Hernandez
Laboratorio Forense de Vida Silvestre LFVS, Edificio Alba, C Rosa de Lima, 1, E 28290 Las Matas, Madrid, Spain
Environ Res 109:837-42. 2009Acute and chronic lead (Pb) poisoning have been recognized as some of the most important causes of mortality for raptors worldwide...
- Ammunition is the principal source of lead accumulated by California condors re-introduced to the wildMolly E Church
Department of Environmental Toxicology, University of California, Santa Cruz 95064, USA
Environ Sci Technol 40:6143-50. 2006..back into the wild in California, Arizona, and Baja California, where monitoring indicates they may accumulate lead to toxic levels...
- Environmental lead exposure, maternal thyroid function, and childhood growthMatthew R Lamb
Department of Epidemiology, Mailman School of Public Health, Columbia University, USA
Environ Res 106:195-202. 2008Prenatal and early-life exposure to lead is hypothesized to have a range of adverse effects on childhood health...
- Risk factors for high blood lead levels among the general population in TaiwanN F Chu
Department of Public Health, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
Eur J Epidemiol 14:775-81. 1998Environmental and occupational lead pollution is a common problem in both developing and industrialized countries. The purpose of this study is to evaluate the risk factors for high blood lead levels among the general population in Taiwan.
- Biosurfactant technology for remediation of cadmium and lead contaminated soilsAsha A Juwarkar
Environmental Biotechnology Division, National Environmental Engineering Research Institute NEERI, Nehru Marg, Nagpur 440 020, India
Chemosphere 68:1996-2002. 2007..This study shows that biosurfactant technology can be an effective and nondestructive method for bioremediation of cadmium and lead contaminated soil.
- Dynamic combinatorial selection of molecules capable of inhibiting the (CUG) repeat RNA-MBNL1 interaction in vitro: discovery of lead compounds targeting myotonic dystrophy (DM1)Peter C Gareiss
Department of Biochemistry and Biophysics, University of Rochester, Rochester, New York 14642, USA
J Am Chem Soc 130:16254-61. 2008..These compounds were also able to inhibit the interaction of GGG-(CUG)(109)-GGG RNA with MBNL1 in vitro, with K(i) values in the low micromolar range...
- Proton magnetic resonance spectroscopy in adults with childhood lead exposureKim M Cecil
Cincinnati Children s Environmental Health Center at Cincinnati Children s Hospital Medical Center, Ohio 45229, USA
Environ Health Perspect 119:403-8. 2011Childhood lead exposure adversely affects neurodevelopment. However, few studies have examined changes in human brain metabolism that may underlie known adverse cognitive and behavioral outcomes.
- Neurotoxic effects and biomarkers of lead exposure: a reviewTalia Sanders
Molecular Toxicology Research Laboratory, NIH RCMI Center for Environmental Health, College of Science, Engineering, and Technology, Jackson State University, Jackson, MS, USA
Rev Environ Health 24:15-45. 2009b>Lead, a systemic toxicant affecting virtually every organ system, primarily affects the central nervous system, particularly the developing brain...
- Polymorphisms of delta-aminolevulinic acid dehydratase (ALAD) and peptide transporter 2 (PEPT2) genes in children with low-level lead exposureChristina Sobin
Border Biomedical Research Center, Toxicology Project and Laboratory of Neurocognitive Genetics and Developmental Neurocognition, Department of Psychology, University of Texas, El Paso, El Paso, TX 79968, USA
Neurotoxicology 30:881-7. 2009Low-level lead exposure during early childhood has long been associated with altered neurocognitive development and diminished cognitive functions. Over nine thousand U.S...
- Evaluation of cumulative lead dose and longitudinal changes in structural magnetic resonance imaging in former organolead workersBrian S Schwartz
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Occup Environ Med 52:407-14. 2010We evaluated whether tibia lead was associated with longitudinal change in brain volumes and white matter lesions in male former lead workers and population-based controls in whom we have previously reported on the cognitive and ..
- National estimates of blood lead, cadmium, and mercury levels in the Korean general adult populationNam Soo Kim
Institute of Environmental and Occupational Medicine, College of Medicine, Soonchunhyang University, 646 Eupnae ri, Shinchang myun, Asan, Choongnam, 336 745, Korea
Int Arch Occup Environ Health 84:53-63. 2011To assess the extent of exposure to lead, cadmium, and mercury in the Korean general adult population using a representative sample.
- Age of greatest susceptibility to childhood lead exposure: a new statistical approachRichard W Hornung
Cincinnati Children s Environmental Health Center, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Environ Health Perspect 117:1309-12. 2009Susceptibility to lead toxicity is often assumed to be greatest during early childhood (e.g., 2 years of age), but recent studies suggest that blood lead concentrations (BPb) taken at 5-7 years of age are more strongly associated with IQ.
- Cumulative lead dose and cognitive function in older adultsKaren Bandeen-Roche
Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore MD 21205, USA
Epidemiology 20:831-9. 2009The current population of older Americans has accumulated substantial lifetime lead doses, which raises concern about the possibility of adverse cognitive outcomes...
- A prospective study of bone lead concentration and death from all causes, cardiovascular diseases, and cancer in the Department of Veterans Affairs Normative Aging StudyMarc G Weisskopf
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
Circulation 120:1056-64. 2009Blood lead concentration has been associated with mortality from different causes in several studies...
- Stimulation of TRPC5 cationic channels by low micromolar concentrations of lead ions (Pb2+)Piruthivi Sukumar
Multidisciplinary Cardiovascular Research Centre and Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, England, UK
Biochem Biophys Res Commun 393:50-4. 2010b>Lead toxicity is long-recognised but continues to be a major public health problem. Its effects are wide-ranging and include induction of hyper-anxiety states...
- Low level lead exposure: history and discoveryHerbert Needleman
University of Pittsburgh, Pittsburgh, PA, USA
Ann Epidemiol 19:235-8. 2009The history of lead toxicity spans 2 millennnia. With increasingly sensitive methods, deficits due to lead exposure have been demonstrated at lower and lower doses. Persuasive evidence suggests that no threshold for lead toxicity exists.
- Prenatal exposure to lead, delta-aminolevulinic acid, and schizophrenia: further evidenceMark G A Opler
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Environ Health Perspect 116:1586-90. 2008A previously conducted study of prenatal lead exposure and schizophrenia using delta-aminolevulinic acid, a biologic marker of Pb exposure, in archived maternal serum samples collected from subjects enrolled in the Childhood Health and ..
- Transcriptional regulation of the NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase ya genes by mercury, lead, and copperHesham M Korashy
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada T6G 2N8
Drug Metab Dispos 34:152-65. 2006..This is the first demonstration that heavy metals regulate the expression of Nqo1 and Gst ya genes through a transcriptional mechanism...
- Neighborhood psychosocial hazards and the association of cumulative lead dose with cognitive function in older adultsThomas A Glass
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Am J Epidemiol 169:683-92. 2009Before the 1970s, today's older Americans were exposed to high levels of lead in the environment. The authors previously reported that lifetime cumulative lead dose was associated with lower cognitive test performance in older adults...
- Pancreas Cancer Specialized Program of Research Excelle*Anton Wellstein; Fiscal Year: 2006..Several of the proposed studies are novel and have the potential to lead to new insights into the biology and clinical management of the disease...
- Development of VN/14-1 and Related Analogs for Breast Cancer TherapyVINCENT COLLINS OFUKA NJAR; Fiscal Year: 2010..Our lead compound, 4-(1)-(1H-imidazol-1-yl)-(E)-retinoic acid (VN/14-1) exhibits exceptional anti-tumor efficacy in several ..
- Development of Pharmacotherapies for Nicotine AddictionFrank Carroll; Fiscal Year: 2005..In addition, data from our experiments should lead to a better understanding of our MTM and lead to the development of tools to further investigate nicotine addiction...
- Signaling in Thymocyte SelectionGerald R Crabtree; Fiscal Year: 2010..signals the antigen experimental evidence supports a mechanism in which intense signals at the antigen receptor lead to the elimination of clones of T cells bearing receptors binding self to elimination cells bearing receptors ..
- Lead, Cadmium,Arsenic, and cardiovascular risk in childrenEliseo Guallar; Fiscal Year: 2011..It is based upon a growing epidemiological literature, by us and others, indicating that exposure to lead, cadmium, or arsenic increases cardiovascular risk...
- Lead, Cadmium,Arsenic, and cardiovascular risk in childrenEliseo Guallar; Fiscal Year: 2010..It is based upon a growing epidemiological literature, by us and others, indicating that exposure to lead, cadmium, or arsenic increases cardiovascular risk...
- Lead, Cadmium,Arsenic, and cardiovascular risk in childrenEliseo Guallar; Fiscal Year: 2009..It is based upon a growing epidemiological literature, by us and others, indicating that exposure to lead, cadmium, or arsenic increases cardiovascular risk...
- d-Penicillamine Chelation in lead-poisoned Children - A Phase ll/lll TrialMichael Shannon; Fiscal Year: 2007Approximately 300,000 children in the US have elevated blood levels (10 mcg/dl or greater). Lead poisoning in children is unequivocally harmful, producing the neurodevelopmental consequences of cognitive losses, attentional difficulties ..
- Neuronal-Astrocytic Communication In VivoKen McCarthy; Fiscal Year: 2009..from our laboratory as well as a number of other laboratories indicate that increases in astrocytic Ca2+ in situ lead to the release of glutamate that can activate both metabotropic glutamate receptors (mGluRs) and ionotropic ..
- Neuronal-Astrocytic Communication In VivoKEN DOUGLAS MCCARTHY; Fiscal Year: 2010..from our laboratory as well as a number of other laboratories indicate that increases in astrocytic Ca2+ in situ lead to the release of glutamate that can activate both metabotropic glutamate receptors (mGluRs) and ionotropic ..