Genomes and Genes
Summary: A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.19, symbol Pb. (Dorland, 28th)
Publications287 found, 100 shown here
- Genotoxic effects of lead: an updated reviewJulia García-Lestón
Department Psychobiology, University of A Coruna, Edificio de Servicios Centrales de Investigación, A Coruna, Spain
Environ Int 36:623-36. 2010b>Lead is a ubiquitous toxic heavy metal with unique physical and chemical properties that make it suitable for a great variety of applications...
- Hazards of heavy metal contaminationLars Jarup
Department of Epidemiology and Public Health, Imperial College, London, UK
Br Med Bull 68:167-82. 2003The main threats to human health from heavy metals are associated with exposure to lead, cadmium, mercury and arsenic...
- Pseudo-second-order model for lead ion sorption from aqueous solutions onto palm kernel fiberYuh Shan Ho
Department of Environmental Sciences, College of Environmental Sciences, Peking University, Beijing 100871, People s Republic of China
J Hazard Mater 129:137-42. 2006The sorption of lead ion onto palm kernel fiber was studied by performing batch kinetic sorption experiments...
- Transcriptome profiling of radish (Raphanus sativus L.) root and identification of genes involved in response to Lead (Pb) stress with next generation sequencingYan Wang
National Key Laboratory of Crop Genetics and Germplasm Enhancement, Engineering Research Center of Horticultural Crop Germplasm Enhancement and Utilization, Ministry of Education of PR China
PLoS ONE 8:e66539. 2013b>Lead (Pb), one of the most toxic heavy metals, can be absorbed and accumulated by plant roots and then enter the food chain resulting in potential health risks for human beings. The radish (Raphanus sativus L...
- Lead iodide perovskite sensitized all-solid-state submicron thin film mesoscopic solar cell with efficiency exceeding 9%Hui Seon Kim
School of Chemical Engineering and Department of Energy Science, Sungkyunkwan University, Suwon 440 746, Korea
Sci Rep 2:591. 2012We report on solid-state mesoscopic heterojunction solar cells employing nanoparticles (NPs) of methyl ammonium lead iodide (CH(3)NH(3))PbI(3) as light harvesters...
- Outbreak of fatal childhood lead poisoning related to artisanal gold mining in northwestern Nigeria, 2010Carrie A Dooyema
Healthy Homes and Lead Poisoning Prevention Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Environ Health Perspect 120:601-7. 2012In May 2010, a team of national and international organizations was assembled to investigate children's deaths due to lead poisoning in villages in northwestern Nigeria.
- Very low lead exposures and children's neurodevelopmentDavid C Bellinger
Children s Hospital Boston, Harvard Medical School, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Curr Opin Pediatr 20:172-7. 2008We remain far from achieving the goal of eliminating lead-associated neurodevelopmental morbidities in children...
- Influence of prenatal lead exposure on genomic methylation of cord blood DNAJ Richard Pilsner
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
Environ Health Perspect 117:1466-71. 2009Fetal lead exposure is associated with adverse pregnancy outcomes and developmental and cognitive deficits; however, the mechanism(s) by which lead-induced toxicity occurs remains unknown...
- Heavy metals (lead, cadmium and mercury) in maternal, cord blood and placenta of healthy womenIman Al-Saleh
Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia
Int J Hyg Environ Health 214:79-101. 2011b>Lead, cadmium and mercury were measured in placental tissue, umbilical cord and maternal blood samples of 1578 women who delivered at the Al-Kharj King Khalid Hospital between 2005 and 2006...
- Potassium-lead-switched G-quadruplexes: a new class of DNA logic gatesTao Li
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China, and Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
J Am Chem Soc 131:15082-3. 2009..Such a K(+)-Pb(2+) switched G-quadruplex, in fact, functions as a two-input INHIBIT logic gate. With the introduction of another input EDTA, this G-quadruplex can be further utilized to construct a reversibly operated IMPLICATION gate...
- The relevance of the individual genetic background for the toxicokinetics of two significant neurodevelopmental toxicants: mercury and leadClaudia Gundacker
Institute of Medical Genetics, Medical University of Vienna, Währinger Strasse 10, A 1090 Vienna, Austria
Mutat Res 705:130-40. 2010The heavy metals mercury and lead are well-known and significant developmental neurotoxicants. This review summarizes the genetic factors that modify their toxicokinetics...
- Time trends in burdens of cadmium, lead, and mercury in the population of northern SwedenMaria Wennberg
Department of Medicine, Skellefteå Hospital, 931 86 Skellefteå, Sweden
Environ Res 100:330-8. 2006..This study addresses time trends for the three toxic elements cadmium (Cd), mercury (Hg), and lead (Pb)...
- Childhood lead poisoning associated with gold ore processing: a village-level investigation-Zamfara State, Nigeria, October-November 2010Yi Chun Lo
Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Environ Health Perspect 120:1450-5. 2012During May-June 2010, a childhood lead poisoning outbreak related to gold ore processing was confirmed in two villages in Zamfara State, Nigeria...
- Study on clinical and biochemical toxicity biomarkers in a zinc-lead mine workersAli Akbar Malekirad
Science and Research Branch, Islamic Azad University IAU, Tehran, Iran
Toxicol Ind Health 26:331-7. 2010The aim of this study was to determine oxidative stress status as well as blood lead (Pb) and zinc (Zn) levels and clinical markers in workers of a Zn-Pb mine...
- Low-level environmental lead exposure and intellectual impairment in children--the current concepts of risk assessmentMarek Jakubowski
Department of Chemical Safety, Nofer Institute of Occupational Medicine, Łódź, Poland
Int J Occup Med Environ Health 24:1-7. 2011b>Lead is an environmental contaminant. The majority of epidemiological research on the health effects of lead has been focused on children, because they are more vulnerable to lead than adults...
- LeadDavid C Bellinger
Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
Pediatrics 113:1016-22. 2004Children differ from adults in the relative importance of lead sources and pathways, lead metabolism, and the toxicities expressed. The central nervous system effects of lead on children seem not to be reversible...
- Association of tobacco and lead exposures with attention-deficit/hyperactivity disorderTanya E Froehlich
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Pediatrics 124:e1054-63. 2009The study objective was to determine the independent and joint associations of prenatal tobacco and childhood lead exposures with attention-deficit/hyperactivity disorder (ADHD), as defined by current diagnostic criteria, in a national ..
- Lead neurotoxicity in children: basic mechanisms and clinical correlatesTheodore I Lidsky
Center for Trace Element Studies and Environmental Neurotoxicology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
Brain 126:5-19. 2003b>Lead has been recognized as a poison for millennia and has been the focus of public health regulation in much of the developed world for the better part of the past century...
- Cadmium and lead contamination in japonica rice grains and its variation among the different locations in southeast ChinaFangmin Cheng
College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310029, PR China
Sci Total Environ 359:156-66. 2006..sites and a field experiment with 12 cultivars grown at 3 ecologically different locations, Cadmium (Cd) and lead (Pb) contamination in milled rice grains and its variation among different locations were investigated in the area ..
- Blood lead below 0.48 micromol/L (10 microg/dL) and mortality among US adultsAndy Menke
Department of Epidemiology, Tulane University SPHTM, 1430 Tulane Ave, New Orleans, LA 70112, USA
Circulation 114:1388-94. 2006Blood lead levels above 0.48 micromol/L (10 microg/dL) in adults have been associated with increased risk of cardiovascular, cancer, and all-cause mortality...
- Fetal lead exposure at each stage of pregnancy as a predictor of infant mental developmentHoward Hu
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
Environ Health Perspect 114:1730-5. 2006The impact of prenatal lead exposure on neurodevelopment remains unclear in terms of consistency, the trimester of greatest vulnerability, and the best method for estimating fetal lead exposure.
- Label-free detection of sub-nanomolar lead(II) ions in aqueous solution using a metal-based luminescent switch-on probeHong Zhang He
Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
Biosens Bioelectron 41:871-4. 2013..It also exhibits good selectivity for Pb(2+) ions over other heavy metal ions. Furthermore, the application of the assay for the detection of Pb(2+) ions in spiked river water samples has been demonstrated...
- Low-level environmental lead exposure and children's intellectual function: an international pooled analysisBruce P Lanphear
Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Environ Health Perspect 113:894-9. 2005b>Lead is a confirmed neurotoxin, but questions remain about lead-associated intellectual deficits at blood lead levels < 10 microg/dL and whether lower exposures are, for a given change in exposure, associated with greater deficits...
- Chronic low-level lead exposure affects the monoaminergic system in the mouse superior olivary complexTyler Fortune
Center for Environmental Health Sciences, Department of Biomedical and Pharmaceutical Sciences, College of Health Professions and Biomedical Sciences, The University of Montana, Missoula, Montana 59812 1552, USA
J Comp Neurol 513:542-58. 2009Low-level lead (Pb) exposure is associated with behavioral and cognitive dysfunction, but it is not clear how Pb produces these behavioral changes. Pb has been shown to alter auditory temporal processing in both humans and animals...
- Associations of early childhood manganese and lead coexposure with neurodevelopmentBirgit Claus Henn
Department of Environmental Health, Harvard School of Public Health, 401 Park Dr, Boston, MA 02215, USA
Environ Health Perspect 120:126-31. 2012..Most toxicologic studies focus on a single agent, although this does not reflect real-world scenarios in which humans are exposed to multiple chemicals...
- Secondhand tobacco smoke: a source of lead exposure in US children and adolescentsAndria Apostolou
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Am J Public Health 102:714-22. 2012We evaluated the relationship between secondhand tobacco smoke (SHS) exposure and blood lead levels in US children and adolescents.
- Association of lead, mercury and cadmium with diabetes in the Korean population: the Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2010S S Moon
Department of Internal Medicine, Dongguk University College of Medicine, Gyeongju, South Korea
Diabet Med 30:e143-8. 2013..We investigated the association of heavy metals, including lead, mercury and cadmium, with diabetes in the Korean population.
- Presynaptic malfunction: the neurotoxic effects of cadmium and lead on the proton gradient of synaptic vesicles and glutamate transportTatiana Borisova
The Department of Neurochemistry, Palladin Institute of Biochemistry, NAS of Ukraine, 9 Leontovicha Street, Kiev 01601, Ukraine
Neurochem Int 59:272-9. 2011....
- Lead and PCBs as risk factors for attention deficit/hyperactivity disorderPaul A Eubig
Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
Environ Health Perspect 118:1654-67. 2010..In this review we present evidence that environmental chemicals, particularly polychlorinated biphenyls (PCBs) and lead, are associated with deficits in many neurobehavioral functions that are also impaired in ADHD.
- Lead-induced hypertension: possible role of endothelial factorsF Khalil-Manesh
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048
Am J Hypertens 6:723-9. 1993The results of this study confirm that low lead (0.01%) but not high lead (0.5%) administration results in increased blood pressure in rats treated for up to 12 months...
- The evidence that lead increases the risk for spontaneous abortionI Hertz-Picciotto
University of North Carolina, Chapel Hill, North Carolina 27599, USA
Am J Ind Med 38:300-9. 2000..occupationally exposed women in several countries, support an increase in pregnancy loss from high maternal lead exposures...
- Renal and neurologic effects of cadmium, lead, mercury, and arsenic in children: evidence of early effects and multiple interactions at environmental exposure levelsClaire de Burbure
Unit of Industrial Toxicology and Occupational Medicine, Faculty of Medicine, Catholic University of Louvain, Clos Chapelle aux Champs 30, B 1200 Brussels, Belgium
Environ Health Perspect 114:584-90. 2006b>Lead, cadmium, mercury, and arsenic are common environmental pollutants in industrialized countries, but their combined impact on children's health is little known...
- Childhood and adult socioeconomic position, cumulative lead levels, and pessimism in later life: the VA Normative Aging StudyJunenette L Peters
Department of Environmental Health, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
Am J Epidemiol 174:1345-53. 2011..There is evidence that individuals with higher lead exposure have poorer health...
- Level of trace elements (copper, zinc, magnesium and selenium) and toxic elements (lead and mercury) in the hair and nail of children with autismMalarveni Damodaran Lakshmi Priya
Department of Biochemistry, Bharathi Women s College, Chennai, 600 108 Tamil Nadu, India
Biol Trace Elem Res 142:148-58. 2011..elements like copper (Cu), zinc (Zn), magnesium (Mg), and selenium (Se) and toxic elements like mercury (Hg), and lead (Pb) in the hair and nail samples of autistic children and to evaluate whether the level of these elements could be ..
- Fibrillization of human tau is accelerated by exposure to lead via interaction with His-330 and His-362Hai Li Zhu
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
PLoS ONE 6:e25020. 2011..b>Lead is a potent neurotoxin for human being especially for the developing children, and Pb(2+) at high concentrations is ..
- Developmental aspects of environmental neurotoxicology: lessons from lead and polychlorinated biphenylsGerhard Winneke
Division of Neurobehavioral Toxicology, Medical Institute of Environmental Hygiene, Heinrich Heine Universitat, Auf m Hennekamp 50, D 40225, Dusseldorf, Germany
J Neurol Sci 308:9-15. 2011..However, for only few of these, namely inorganic lead, arsenic, organic mercury and polychlorinated biphenyls (PCBs), human evidence is available to suggest that these ..
- Association of blood lead (Pb) and plasma homocysteine: a cross sectional survey in Karachi, PakistanMohsin Yakub
Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
PLoS ONE 5:e11706. 2010High blood lead (Pb) and hyperhomocysteinemia have been found to be associated with cardiovascular disease (CVD). Mean blood Pb and mean plasma homocysteine levels have been reported to be high in Pakistani population...
- Perinatal lead and mercury exposure in AustriaClaudia Gundacker
Institute of Medical Genetics, Medical University of Vienna, Währinger Strasse 10, 1090 Vienna, Austria
Sci Total Environ 408:5744-9. 2010The heavy metals lead (Pb) and mercury (Hg) are ubiquitous environmental pollutants with high neurotoxic potential...
- Relationship of thyroid hormone levels to levels of polychlorinated biphenyls, lead, p,p'- DDE, and other toxicants in Akwesasne Mohawk youthLawrence M Schell
Department of Anthropology, University at Albany, State University of New York, Albany, New York 12222, USA
Environ Health Perspect 116:806-13. 2008..Chronic exposure to multiple toxicants is common but difficult to analyze, and most prior studies have focused on adults or newborns, creating a gap in our understanding of multitoxicant effects among adolescents...
- Altered myelination and axonal integrity in adults with childhood lead exposure: a diffusion tensor imaging studyChristopher J Brubaker
Cincinnati Children s Environmental Health Center at the Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Neurotoxicology 30:867-75. 2009Childhood lead exposure is associated with adverse cognitive, neurobehavioral and motor outcomes, suggesting altered brain structure and function...
- Lead(II) as a probe for investigating RNA structure in vivoMagnus Lindell
Institute of Cell and Molecular Biology, Biomedical Center, Uppsala University, Sweden
RNA 8:534-41. 2002..we describe a simple and reliable method for RNA structure determination in vivo, using the divalent ion, lead(II), as a structural probe...
- Water arsenic exposure and intellectual function in 6-year-old children in Araihazar, BangladeshGail A Wasserman
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Environ Health Perspect 115:285-9. 2007..We recently reported results of a cross-sectional investigation of intellectual function in 10-year-olds in Bangladesh, who had been exposed to arsenic from drinking water in their home wells...
- Lead toxicity, a review of the literature. Part 1: Exposure, evaluation, and treatmentLyn Patrick
Altern Med Rev 11:2-22. 2006The phasing out of leaded gasoline for transportation vehicles between 1973 and 1995 and the removal of lead from paint by federal mandate by 1978 have resulted in substantial lowering of mean blood lead levels in all segments of the U.S...
- Mechanisms of lead-induced hypertension and cardiovascular diseaseNosratola D Vaziri
Division of Nephrology and Hypertension, UCI Medical Center, 101 The City Dr, Bldg 53, Rm 125, Rt 81, Orange, CA 92868, USA
Am J Physiol Heart Circ Physiol 295:H454-65. 2008b>Lead is a ubiquitous environmental toxin that is capable of causing numerous acute and chronic illnesses...
- Neurotoxic effects and biomarkers of lead exposure: a reviewTalia Sanders
Molecular Toxicology Research Laboratory, NIH RCMI Center for Environmental Health, College of Science, Engineering, and Technology, Jackson State University, Jackson, MS, USA
Rev Environ Health 24:15-45. 2009b>Lead, a systemic toxicant affecting virtually every organ system, primarily affects the central nervous system, particularly the developing brain...
- The role of environmental mercury, lead and pesticide exposure in development of amyotrophic lateral sclerosisFrank O Johnson
Center for Integrative Toxicology and Neuroscience Program and Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, United States
Neurotoxicology 30:761-5. 2009..been reported, although circumstantial epidemiological evidence has implicated exposure to heavy metals such as lead and mercury, industrial solvents and pesticides especially organophosphates and certain occupations such as playing ..
- Mass lead intoxication from informal used lead-acid battery recycling in dakar, senegalPascal Haefliger
Department of Public Health and Environment, World Health Organization, Geneva, Switzerland
Environ Health Perspect 117:1535-40. 2009..died from a rapidly progressive central nervous system disease of unexplained origin in a community involved in the recycling of used lead-acid batteries (ULAB) in the suburbs of Dakar, Senegal. We investigated the cause of these deaths.
- Environmental tobacco smoke (ETS) exposure in children with asthma-relation between lead and cadmium, and cotinine concentrations in urineStefan Willers
Unit of Preventive Medicine, Heart and Lung Center, Lund University Hospital, SE 221 85 Lund, Sweden
Respir Med 99:1521-7. 2005..The corresponding concentrations of the heavy metals cadmium and lead in dust and urine (U-Cd; U-Pb) were determined in the same samples...
- Blood cadmium and lead and chronic kidney disease in US adults: a joint analysisAna Navas-Acien
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Am J Epidemiol 170:1156-64. 2009Environmental cadmium and lead exposures are widespread, and both metals are nephrotoxic at high exposure levels...
- A critical review of biomarkers used for monitoring human exposure to lead: advantages, limitations, and future needsFernando Barbosa
Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
Environ Health Perspect 113:1669-74. 2005b>Lead concentration in whole blood (BPb) is the primary biomarker used to monitor exposure to this metallic element. The U.S. Centers for Disease Control and Prevention and the World Health Organization define a BPb of 10 microg/dL (0...
- House dust as possible route of environmental exposure to cadmium and lead in the adult general populationJanneke Hogervorst
Centrum voor Milieukunde, Limburgs Universitair Centrum, Diepenbeek, Belgium
Environ Res 103:30-7. 2007..We investigated the relations between biomarkers of exposure to cadmium and lead, and the metal loading rates in house dust in the adult residents of an area with a soil cadmium concentration of > ..
- Blood lead level and kidney function in US adolescents: The Third National Health and Nutrition Examination SurveyJeffrey J Fadrowski
Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, MD, USA
Arch Intern Med 170:75-82. 2010Chronic, high-level lead exposure is a known risk factor for kidney disease...
- Blood lead levels of children and its trend in ChinaKangmin He
Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China
Sci Total Environ 407:3986-93. 2009To evaluate Chinese children's blood lead levels (BLLs) and identify its distribution features, we collected articles on children's BLLs published from Jan, 2004 to Aug, 2007 with sampling time since 2001, by searching Chinese Biomedical ..
- Association between blood lead and the risk of amyotrophic lateral sclerosisFang Fang
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
Am J Epidemiol 171:1126-33. 2010..a 2003-2007 case-control study including 184 cases and 194 controls to examine the association between blood lead and the risk of amyotrophic lateral sclerosis (ALS) among US veterans and to explore the influence on this ..
- Fetal growth restriction is related to placental levels of cadmium, lead and arsenic but not with antioxidant activitiesMiguel N Llanos
Laboratory of Nutrition and Metabolic Regulation, Institute of Nutrition and Food Technology INTA, University of Chile, Macul 5540, Casilla 138 11, Santiago, Chile
Reprod Toxicol 27:88-92. 2009..and arsenic were measured by Instrumental Neutron Activation Analysis (INAA), and iron, copper, cadmium and lead by Atomic Absorption Spectrometry (AAS)...
- Trends in blood lead levels and blood lead testing among US children aged 1 to 5 years, 1988-2004Robert L Jones
Centers for Disease Control and Prevention, National Center for Environmental Health, 4770 Buford Hwy, Atlanta, GA 30341
Pediatrics 123:e376-85. 2009To evaluate trends in children's blood lead levels and the extent of blood lead testing of children at risk for lead poisoning from national surveys conducted during a 16-year period in the United States.
- Exposure to arsenic and lead and neuropsychological development in Mexican childrenJ Calderon
Facultad de Medicina, Universidad Autonoma de San Luis Potosi, Av Venustiano Carranza 2405, 78210 San Luis Potosi, Mexico
Environ Res 85:69-76. 2001This cross-sectional study examined the effects of chronic exposure to lead (Pb), arsenic (AS) and undernutrition on the neuropsychological development of children...
- Co-exposure to environmental lead and manganese affects the intelligence of school-aged childrenYeni Kim
Division of Child and Adolescent Psychiatry, Department of Psychiatry and Institute of Human Behavioral Medicine, Seoul National University College of Medicine, 28 YeonGun Dong, Chongno Gu, Seoul, 110 744, Republic of Korea
Neurotoxicology 30:564-71. 2009Exposure to environmental levels of lead (Pb) and manganese (Mn) has been associated with detrimental effects to neurodevelopment...
- Nonlinear association between soil lead and blood lead of children in metropolitan New Orleans, Louisiana: 2000-2005Howard W Mielke
Xavier University of Louisiana, College of Pharmacy, 1 Drexel Drive, New Orleans, Louisiana 70125, USA
Sci Total Environ 388:43-53. 2007Metropolitan New Orleans is unique because it has a universal blood lead (BL) screening dataset (n=55,551) from 2000-2005 spatially coupled with a soil lead (SL) dataset (n=5467) completed in 2000...
- Lead promotes abasic site accumulation and co-mutagenesis in mammalian cells by inhibiting the major abasic endonuclease Ape1Daniel R McNeill
Laboratory of Molecular Gerontology, GRC, National Institute on Aging, IRP, NIH, Baltimore, Maryland 21224 6825, USA
Mol Carcinog 46:91-9. 2007b>Lead is a widespread environmental toxin, found in contaminated water sources, household paints, and certain occupational settings...
- Electrochemical microsensors for the detection of cadmium(II) and lead(II) ions in plantsOlga Krystofova
Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Zemedelska 1, CZ 613 00 Brno, Czech Republic
Sensors (Basel) 10:5308-28. 2010..PalmSens) and a homemade micropotentiostat] for easy-to-use and sensitive determination of cadmium(II) and lead(II) ions...
- Multiple environmental chemical exposures to lead, mercury and polychlorinated biphenyls among childbearing-aged women (NHANES 1999-2004): Body burden and risk factorsMarcella Remer Thompson
Superfund Research Program, Brown University, Providence, Rhode Island, USA
Environ Res 121:23-30. 2013b>Lead, mercury and polychlorinated biphenyls (PCBs) are neurotoxicants with intergenerational health consequences from maternal body burden and gestational exposures...
- Prenatal low-level lead exposure and developmental delay of infants at age 6 months (Krakow inner city study)Wieslaw Jedrychowski
Epidemiology and Preventive Medicine, Jagiellonian University, Collegium Medicum, Krakow, Poland
Int J Hyg Environ Health 211:345-51. 2008..to assess the neurocognitive status of 6-month-old infants whose mothers were exposed to low but varying amounts of lead during pregnancy...
- Use of geographic information system technology to aid Health Department decision making about childhood lead poisoning prevention activitiesD B Reissman
Lead Poisoning Prevention Branch, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Environ Health Perspect 109:89-94. 2001..Control and Prevention recommend that local public health agencies use local data to identify children at risk for lead exposure to ensure that they receive preventive services...
- Disrupted pro- and antioxidative balance as a mechanism of neurotoxicity induced by perinatal exposure to leadIrena Baranowska-Bosiacka
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp 72 str, 70 111 Szczecin, Poland
Brain Res 1435:56-71. 2012The aim of this paper was to examine if pre- and neonatal exposure that results in lead (Pb) concentration below 'safe level' (10 μg/dL) in offspring blood may cause disruption of the pro/antioxidant balance in the developing rat brain...
- Response inhibition and error monitoring during a visual go/no-go task in inuit children exposed to lead, polychlorinated biphenyls, and methylmercuryOlivier Boucher
Centre de Recherche du Centre Hospitalier Universitaire de Québec, Quebec, Canada
Environ Health Perspect 120:608-15. 2012b>Lead (Pb) and polychlorinated biphenyls (PCBs) are neurotoxic contaminants that have been related to impairment in response inhibition.
- Biosorption of cadmium, lead and copper with calcium alginate xerogels and immobilized Fucus vesiculosusY N Mata
Department of Materials Science and Metallurgical Engineering, Complutense University of Madrid, Ciudad Universitaria s n, 28040 Madrid, Spain
J Hazard Mater 163:555-62. 2009..The Langmuir maximum biosorption capacity increased twofold for cadmium, 10 times for lead, and decreased by half for copper...
- Environmental lead exposure and progressive renal insufficiencyJ L Lin
Poison Center and Division of Nephrology, Chang Gung Memorial Hospital, 199, Tung Hwa North Road, Taipei, Taiwan, Republic of China
Arch Intern Med 161:264-71. 2001Several recent studies show that serum creatinine level or creatinine clearance is inversely associated with blood lead levels. However, the studies did not allow direct inferences about causality.
- Lead in edible mushrooms: levels and bioaccumulation factorsM Angeles García
Department of Toxicology, Faculty of Veterinary University of Santiago de Compostela, Lugo, Spain
J Hazard Mater 167:777-83. 2009b>Lead content was determined in 238 samples of 28 species of edible mushrooms collected from different sites in the province of Lugo (NW Spain) during 2005 and 2006...
- Association between prenatal lead exposure and blood pressure in childrenAimin Zhang
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109 2029, USA
Environ Health Perspect 120:445-50. 2012b>Lead exposure in adults is associated with hypertension...
- The potential effect of metallothionein 2A -5A/G single nucleotide polymorphism on blood cadmium, lead, zinc and copper levelsZeliha Kayaalti
Ankara University Institute of Forensic Sciences Dikimevi, 06590 Ankara, Turkey
Toxicol Appl Pharmacol 256:1-7. 2011..This study suggests that having the GG genotype individuals may be more sensitive for the metal toxicity and they should be more careful about protecting their health against the toxic effects of the heavy metals...
- The relationship between blood and serum lead levels in peripartum women and their respective umbilical cordsJefferson H Amaral
Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Ribeirao Preto, SP, Brazil
Basic Clin Pharmacol Toxicol 107:971-5. 2010Foetal exposure to lead (Pb) during pregnancy is a major problem. However, no previous study has examined whether Pb concentrations in blood (Pb-B) and in serum (Pb-S) from pregnant women correlate with Pb-B and Pb-S in the foetuses...
- Metals and women's healthM Vahter
Institute of Environmental Medicine, Karolinska Institutet, Sweden
Environ Res 88:145-55. 2002..The present work aims at reviewing exposure and health effects of cadmium, nickel, lead, mercury, and arsenic manifested differently in women than in men...
- Environmental lead exposure and progression of chronic renal diseases in patients without diabetesJa Liang Lin
Division of Nephrology, Chang Gung Memorial Hospital, Lin Kou Medical Center, Medical College of Chang Gung University, Taipei, Taiwan
N Engl J Med 348:277-86. 2003Previous research suggests that environmental lead exposure correlates with age-related decreases in renal function.
- Suppression of Chlorella vulgaris growth by cadmium, lead, and copper stress and its restoration by endogenous brassinolideAndrzej Bajguz
Department of Plant Biochemistry and Toxicology, Institute of Biology, University of Bialystok, Swierkowa 20 B, 15 950 Bialystok, Poland
Arch Environ Contam Toxicol 60:406-16. 2011..vulgaris cultures treated with 10(-8) M brassinolide (BL) were exposed to 10(-6)-10(-4) M heavy metals (cadmium, lead and copper) application...
- Exposure to Pb, Cd, and As mixtures potentiates the production of oxidative stress precursors: 30-day, 90-day, and 180-day drinking water studies in ratsMargaret H Whittaker
Toxicology Program, The University of Maryland at Baltimore, Baltimore, MD, USA
Toxicol Appl Pharmacol 254:154-66. 2011..Interactive effects of lead (Pb), cadmium (Cd) and arsenic (As) were evaluated in 30-, 90-, and 180-day factorial design drinking water studies ..
- Nephrotoxicity of cadmium & leadH C Gonick
Division of Nephrology, West Los Angeles Healthcare Center, Los Angeles, California 90073, USA
Indian J Med Res 128:335-52. 2008Cadmium and lead are divalent cations with a propensity to settle in the proximal tubule of the nephron, leading to nephrotoxicity. The pathophysiological results, however, tend to diverge...
- Lead exposure and cardiovascular disease--a systematic reviewAna Navas-Acien
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Environ Health Perspect 115:472-82. 2007This systematic review evaluates the evidence on the association between lead exposure and cardiovascular end points in human populations.
- Molecular neurobiology of lead (Pb(2+)): effects on synaptic functionApril P Neal
Department of Pharmacology and Toxicology, Michigan State University, B307 Life Sciences Building, East Lansing, MI 48824, USA
Mol Neurobiol 42:151-60. 2010b>Lead (Pb(2+)) is a ubiquitous environmental neurotoxicant that continues to threaten public health on a global scale. Epidemiological studies have demonstrated detrimental effects of Pb(2+) on childhood IQ at very low levels of exposure...
- The relation of lead neurotoxicity to the event-related potential P3b component in Inuit children from arctic QuébecOlivier Boucher
Ecole de Psychologie, Universite Laval, Quebec, Canada
Neurotoxicology 30:1070-7. 2009..in many experimental paradigms, was measured in Inuit children from Nunavik (Arctic Québec, Canada) to assess lead (Pb) neurotoxicity...
- Potentially toxic metal contamination of urban soils and roadside dust in Shanghai, ChinaGuitao Shi
Key Laboratory of Geographic Information Science of Ministry of Education, East China Normal University, Shanghai 200062, China
Environ Pollut 156:251-60. 2008....
- Cellular mechanisms of lead neurotoxicityAnibal Garza
Instituto de Fisiologia, Universidad Autonoma de Puebla, Pue, Mexico
Med Sci Monit 12:RA57-65. 2006b>Lead (Pb2+), a heavy metal, has been used by humans for many technological purposes, which is the main reason for its present widespread distribution...
- Lead-induced oxidative stress adversely affects health of the occupational workersD A Khan
Department of Pathology Army Medical College, National University Sciences and Technology, Rawalpindi, Pakistan
Toxicol Ind Health 24:611-8. 2008b>Lead is a persistent toxic metal and associated with impairment of various body functions in occupational workers...
- Metallothioneins are required for formation of cross-adaptation response to neurobehavioral toxicity from lead and mercury exposure in nematodesBoping Ye
College of Life Science and Technology, China Pharmaceutical University, Nanjing, China
PLoS ONE 5:e14052. 2010..Therefore, the normal formation of cross-adaptation response to neurobehavioral toxicity induced by metal exposure may need the enough accumulation of MTs protein in animal tissues...
- The detoxification of lead in Sedum alfredii H. is not related to phytochelatins but the glutathioneD K Gupta
Ministry of Education Key Laboratory of Environmental Remediation and Ecosystem Health, Zhejiang University, Hua jian chi Campus, Hangzhou 310029, China
J Hazard Mater 177:437-44. 2010..These results suggest that enzymatic and non-enzymatic antioxidants play a key role in the detoxification of Pb-induced toxic effects in Sedum alfredii. This plant can be used as an indicator species for Pb contamination...
- Heavy metals exposure and hearing loss in US adolescentsJosef Shargorodsky
Channing Laboratory, 181 Longwood Ave, Boston, MA 02115, USA
Arch Otolaryngol Head Neck Surg 137:1183-9. 2011..Hearing loss is common and, in young persons, can compromise social development and educational achievement. Exposure to heavy metals has been proposed as an important risk factor for hearing loss...
- Longitudinal associations between blood lead concentrations lower than 10 microg/dL and neurobehavioral development in environmentally exposed children in Mexico CityMartha M Téllez-Rojo
Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
Pediatrics 118:e323-30. 2006..that 10 microg/dL, the current Centers for Disease Control and Prevention screening guideline for children's blood lead level, should not be interpreted as a level at which adverse effects do not occur...
- A population-based assessment of blood lead levels in relation to inflammationNatthapol Songdej
Department of Community and Preventive Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Environ Res 110:272-7. 2010Some experimental and observational research suggests that inflammation may be an important mediator of lead toxicity. However, lead-induced inflammation has not been well-studied in non-occupationally exposed populations.
- Monitoring of lead, cadmium, chromium and nickel in placenta from an e-waste recycling town in ChinaYongyong Guo
Analytical Cytology Laboratory, Shantou University Medical College, Guangdong, P R China
Sci Total Environ 408:3113-7. 2010..from unregulated electronic waste (e-waste) recycling in Guiyu, China, and thus may contribute to the elevation of lead and other heavy metals levels in placenta...
- Lead and bisphenol A concentrations in the Canadian populationTracey Bushnik
Health Analysis Division, Statistics Canada, Ottawa, Ontario K1A0T6
Health Rep 21:7-18. 2010b>Lead is a known toxicant that occurs naturally in the environment. Bisphenol A (BPA) is an industrial chemical used primarily in polycarbonate plastic and epoxy resins...
- Effects of lead exposure on oxidative stress biomarkers and plasma biochemistry in waterbirds in the fieldMonica Martinez-Haro
Instituto de Investigación en Recursos Cinegéticos CSIC UCLM JCCM, Ronda de Toledo s n, 13071 Ciudad Real, Spain
Environ Res 111:530-8. 2011Medina lagoon in Andalusia has one of the highest densities of spent lead (Pb) shot in Europe...
- The effect of long-term low-dose lead exposure on thyroid function in adolescentsBumin Dundar
Department of Pediatrics, Faculty of Medicine, Suleyman Demirel University, Merkez 32040, Isparta, Turkey
Environ Res 101:140-5. 2006This study investigated blood lead (Pb-B) levels and Pb-B effects on thyroid functions in long-term low-level-lead-exposed male adolescents who work as auto repairers...
- Lead exposure: a contributing cause of the current breast cancer epidemic in Nigerian womenOlusegun I Alatise
Department of Anatomy and Cell Biology, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Nigeria
Biol Trace Elem Res 136:127-39. 2010..This suggested that the associated widespread contamination of the soil and of the water supplies by lead (Pb) and other industrial metals was a major contributing cause...
- Bone lead levels and blood pressure endpoints: a meta-analysisAna Navas-Acien
Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
Epidemiology 19:496-504. 2008Previous reviews have shown increases in blood pressure and hypertension associated with increases in lead levels in blood...
- The influence of age of lead exposure on adult gray matter volumeChristopher J Brubaker
Cincinnati Children s Environmental Health Center, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Neurotoxicology 31:259-66. 2010Childhood lead exposure is associated with decreased cognitive abilities and executive functioning localized within the prefrontal cortex...
- New and evolving concepts in the neurotoxicology of leadL D White
National Center for Environmental Assessment, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Appl Pharmacol 225:1-27. 2007b>Lead (Pb) is a xenobiotic metal with no known essential function in cellular growth, proliferation, or signaling...
- Lead induced oxidative damage and its response to combined administration of alpha-lipoic acid and succimers in ratsManisha Pande
Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior, India
Toxicology 177:187-96. 2002..acid (LA) has been reported to be highly effective in improving the thiol capacity of the cells and in reducing lead induced oxidative stress...
- Lead in pharmaceutical products and dietary supplementsJohn F Kauffman
U S Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Sciences, Division of Pharmaceutical Analysis, 1114 Market St, St Louis, MO 63101, USA
Regul Toxicol Pharmacol 48:128-34. 2007The objective of this study is to determine lead concentrations in a variety of widely used pharmaceutical products, and to assess the risk of lead exposure from using these products...
- Lead, zinc, cadmium, mercury, selenium and copper in Greenland caribou and reindeer (Rangifer tarandus)P Aastrup
Department of Arctic Environment, National Environmental Research Institute, Copenhagen, Denmark
Sci Total Environ 245:149-59. 2000..The levels of lead, zinc, cadmium, mercury, selenium, and copper were determined, and analyzed in relation to location, two seasons, ..
- Environmental exposure to lead, but not other neurotoxic metals, relates to core elements of ADHD in Romanian children: performance and questionnaire dataRodica Nicolescu
Institutul de Sănătate Publică, Str Dr Leonte 1 3, 050463 Bucuresti, Romania
Environ Res 110:476-83. 2010..features of the attention-deficit hyperactivity disorder (ADHD) have been studied in pediatric environmental lead research...
- Biomarkers of lead exposure and DNA methylation within retrotransposonsRobert O Wright
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 118:790-5. 2010..Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a marker of cumulative exposure, may therefore better predict DNA methylation than does blood lead.
- STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGYKeri Hammel; Fiscal Year: 2013..It can lead to macular edema, a swelling of the retina that is a common source of vision loss...
- STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGYKeri Hammel; Fiscal Year: 2012..It can lead to macular edema, a swelling of the retina that is a common source of vision loss...
- Discovery metabolite profiling of the prolyl peptidasesAlan Saghatelian; Fiscal Year: 2009..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
- Genetic variation and regulatory networks: Mechanisms and complexityDANA PE ER; Fiscal Year: 2009..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
- Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator ArraysRyan Bailey; Fiscal Year: 2009..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
- NIH Director's Pioneer AwardJunying Yuan; Fiscal Year: 2009..No Abstract provided ..
- NIH Director's Pioneer AwardERICH JARVIS; Fiscal Year: 2009..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
- Prevention of Complications in ThalassemiaElliott P Vichinsky; Fiscal Year: 2011..care to patients throughout California, providing outreach and education to patients and communities, playing a lead role in national research trials in thalassemia, and enrolling patients from CHRCO in the CDC Thalassemia Universal ..
- Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic DiseasStephen C Strom; Fiscal Year: 2010..to investigate other liver based diseases such as Wilson's and Alpha-1-antitrypsin deficiency and may even lead to better-humanized models for primary, acute liver failure and viral, alcoholic and autoimmune hepatitis and even ..
- Optimization of DNA Repair by Abh8Lauren Endres; Fiscal Year: 2013..We expect that the deletion of Abh8-/- in our mouse model will lead to defects in DNA repair and that this will eventually lead to widespread genomic instability and cancer ..
- National Network of Libraries of Medicine (NN/LM) Region 2 Javier Crespo; Fiscal Year: 2010..Collaborations with affiliate network members such as public libraries and community-based organizations often lead to outreach projects with broad community impact. Specifically the contractor shall undertake the following: 1...
- National Network of Libraries of Medicine (NN/LM) Region 2 DENNIS PATTRATH; Fiscal Year: 2010..Collaborations with affiliate network members such as public libraries and community-based organizations often lead to outreach projects with broad community impact. Specifically the contractor shall undertake the following: 1...
- Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, ObesitRobert A Harris; Fiscal Year: 2012..The long-term objective is to find inhibitors of the PDKs that will lead to development of effective drugs for the treatment of these conditions...
- CFI Pathogen Inactivation TechnologyTrevor P Castor; Fiscal Year: 2010..are to: (1) design and construct laboratory-scale prototypes to conduct evaluation and trade-off studies that will lead to the selection of a commercial-scale SFS-CFI design to achieve >6 logs of inactivation levels of nonenveloped ..
- National Network of Libraries of Medicine - Region 2JM J TOOEY; Fiscal Year: 2013..Collaborations with affiliate network members such as public libraries and community-based organizations often lead to outreach projects with broad community impact...
- National Network of Libraries of Medicine - Region 2JM J TOOEY; Fiscal Year: 2012..Collaborations with affiliate network members such as public libraries and community-based organizations often lead to outreach projects with broad community impact...
- National Network of Libraries of Medicine - Region 2JM J TOOEY; Fiscal Year: 2011..Collaborations with affiliate network members such as public libraries and community-based organizations often lead to outreach projects with broad community impact...
- National Network of Libraries of Medicine (NN/LM) Region 3Ruth Holst; Fiscal Year: 2010..Collaborations with affiliate network members such as public libraries and community-based organizations often lead to outreach projects with broad community impact. Specifically the contractor shall undertake the following: 1...
- Vaccine Development for Falciparum Malaria in Pregnant Women and Their OffspringIan C Michelow; Fiscal Year: 2013..b>Lead candidate antigens will then be downselected using bioinformatics and surface localization studies, as well as ..
- National Network of Libraries of Medicine (NN/LM) Region 3Ruth Holst; Fiscal Year: 2009
- Immune Regulation of Bone HomeostasisMERVYN NEALE WEITZMANN; Fiscal Year: 2012DESCRIPTION (provided by applicant): Bone fractures resulting from osteoporosis lead to significant health costs, morbidity, loss of mobility, and often mortality in aged individuals...
- Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS FactorVirginia J Savin; Fiscal Year: 2010..cells, its activity in injuring glomeruli, and that fact that antibody to CLC blocks the effect of FSGS plasma lead us to the proposed studies to define its role in this serious kidney disease...
- Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot StudyJill M Wecht; Fiscal Year: 2010..We also anticipate that falls in cardiac output and renal hypoperfusion will lead to activation of the renin-angiotensin system, the chronic up- regulation of which has been associated with ..
- National Network of Libraries of Medicine - Region 3Ruth Holst; Fiscal Year: 2013
- National Network of Libraries of Medicine - Region 3Ruth Holst; Fiscal Year: 2011
- National Network of Libraries of Medicine - Region 3Ruth Holst; Fiscal Year: 2012
- Hypothalamic Orexin Role in Menopause-Associated Hot Flashes and Mood/Sleep DisruPHILIP LEE JOHNSON; Fiscal Year: 2013..hot flashes with emphasis on the hypothalamic orexin system;and 7) I will provide mechanistic studies that will lead to a translational clinical protocol finding a novel use of an orexin receptor antagonist submitted for FDA ..
- Brain Activation responses in adolescents with genetic predisposition to obesitySusan Carnell; Fiscal Year: 2011..in satiety/inhibition of food intake areas, reflecting differences in the processing of food stimuli which may lead to obesity...
- H1R Signaling and Immune Deviation in EAECory Teuscher; Fiscal Year: 2013..Proper folding and cell surface expression of GPCRs is required for ligand binding and signaling. Mutations that lead to improper folding and/or intracellular trafficking comprise the largest class of GPCR mutations that result in ..
- Pilot and definitive studies to evaluate Insertional MutagenesisLU TAYLOR; Fiscal Year: 2012..smoke, endotoxin, and allergen) that are known to perturb biologic systems resulting in changes in the airway that lead to the development of chronic airway disease...
- Studies to Evaluate the Toxicological Potential of Test ArticlesLU TAYLOR; Fiscal Year: 2010..smoke, endotoxin, and allergen) that are known to perturb biologic systems resulting in changes in the airway that lead to the development of chronic airway disease...
- National Network of Libraries of Medicine (NN/LM) region 4Claire Hamasu; Fiscal Year: 2010
- Ligand Directed Transdermal siRNA Delivery to Improve Wound HealingDavid M Evans; Fiscal Year: 2012..Loss of the integrity of large portions of the skin as a result of wounds and wound-related infection may lead to major disability or even death. Every year in the United States more than 1.25 million people suffer burns and 6...
- Enhanced iron removal with peptide linked chelators targeted to ferritinElizabeth C Theil; Fiscal Year: 2010..the genetic anemias, Sickle Cell Disease (SCD) and the Thalassemias (THL), because the regular blood transfusions, lead to accumulations of toxic, sometime fatal amounts of iron that must be removed...
- Multi-targeted Countermeasures against Acute and Delayed Effects of OP ExposureJohn A Butera; Fiscal Year: 2013..This would set the stage for a final lead optimization campaign focused on identifying pre- clinical leads with well-balanced in vivo PK parameters during an ..
- National Network of Libraries of Medicine (NN/LM) region 4Claire Hamasu; Fiscal Year: 2009
- Principles of Therapy in Cerebellar Disease: Explorations in Ion Channel MutantsJOHN SAMUEL STAHL; Fiscal Year: 2013..The search for better treatments would be aided by a better understanding of how specific diseases lead to the symptoms of cerebellar disease, and the mechanisms by which the drugs we do have produce their benefits...
- Tyrosine Availability Influences Mesocortico-Limbic CatecholaminesGEORGE EUGENE JASKIW; Fiscal Year: 2012..This would lead to periods of abnormally high and abnormally low tyrosine in the brain...
- Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?Qinghua Sun; Fiscal Year: 2013..the mechanisms of air pollution exposure on obesity development and associated vascular dysfunction, which may lead to the new policies/interventions in greener energy plants and automobiles, stricter air quality standards, and ..
- National Network of Libraries of Medicine (NN/LM) Region 5MICHELLE MALIZIA; Fiscal Year: 2010
- Optimized Growth Media to Detect Intracellular Bacteria Implicated in Chronic DisPATRICIA MASCARELLI; Fiscal Year: 2011..Our expectation is that the development of this testing platform will lead to medical breakthroughs in the diagnosis and treatment of chronic disease and will provide extensive savings in ..
- Effects of Testosterone and Genetic Factors on Psychological and Motor Function iNICOLE RENEE TARTAGLIA; Fiscal Year: 2013..We hypothesize that testosterone therapy initiated in early puberty in KS/XXY will lead to improvements in executive function, psychosocial functioning, and motor skills, while externalizing behaviors ..
- Targeting Galectin-3 with novel drugs for treatment of eczemaFu Tong Liu; Fiscal Year: 2010..We hope the proposed studies will definitively validate galectin-3 as a target for treating atopic dermatitis and lead to the development of a novel therapy for this disease.
- Reactive (AA)AmyloidosisMerrill D Benson; Fiscal Year: 2013..These fibril deposits then compromise normal tissue function and lead to progressive organ failure...
- Retinoid and Carotenoid Depletion in Patients at High-Risk for Liver CancerPeter H Gann; Fiscal Year: 2010..Completion of the proposed work will lead directly to full-scale proposals for Phase II trials in CLD patients, with tissue endpoints and either dietary or ..
- National Network of Libraries of Medicine (NN/LM) Region 5MICHELLE MALIZIA; Fiscal Year: 2009
- National Network of Libraries of Medicine (NN/LM) Region 6CATHY BURROUGHS; Fiscal Year: 2009
- Structure and function of urea transportersMing Zhou; Fiscal Year: 2013..relationships of mammalian UT in an atomic-resolution, three-dimensional context which eventually we hope will lead to the development of new therapeutic reagents...
- National Network of Libraries of Medicine (NN/LM) Region 7TAMARA COMBS; Fiscal Year: 2010
- Cystathionine beta synthase (CBS) and angiogenesisPriyabrata Mukherjee; Fiscal Year: 2013..impairment of the transsulfuration pathway via pharmacological inhibition or genetic deletion/mutation of CBS may lead to, a) hyperhomocysteninemia (HHcy);b) reduction in cellular glutathione GSH level due to lack of availability of ..
- Discovery of Small Molecule MBT Domain AntagonistsSTEPHEN VERNON FRYE; Fiscal Year: 2010..of these modifications create a binding site to recruit other proteins which can 'read'these marks and lead to cell-type and environmentally appropriate gene expression or repression...
- Development of VN/14-1 and Related Analogs for Breast Cancer TherapyVINCENT COLLINS OFUKA NJAR; Fiscal Year: 2013..Our lead compound, 4-(1)-(1H-imidazol-1-yl)-(E)-retinoic acid (VN/14-1) exhibits exceptional anti-tumor efficacy in several ..
- ROLE OF Rac AND REACTIVE OXYGEN SPECIES IN KAPOSI'S SARCOMA VIRAL ONCOGENESISEnrique A Mesri; Fiscal Year: 2013..The identification of human and viral genes that are the cause of KS carcinogenesis is important because it could lead to the identification of new therapeutic targets...
- Neurobehavioral Correlates of Familial/genetic obesity risk in adolescentsSusan Carnell; Fiscal Year: 2013..in satiety/inhibition of food intake areas, reflecting differences in the processing of food stimuli which may lead to obesity...
- Role of Txnip in adapting fuel metabolism to nutritional stateSIMON HUI; Fiscal Year: 2013..Results of this proposed research will provide fundamental information that may lead to better prevention and/or therapeutics for diabetes and cardiovascular disease in humans.
- Impact of the P479L Variant in CPT1A on Infant Mortality in AlaskaDavid M Koeller; Fiscal Year: 2011..Like other disorders of fatty acid oxidation, CPT1A deficiency can lead to sudden infant death...
- Role of SCD1 and Dietary Methionine Restriction on Energy HomeostasisERIC PAUL PLAISANCE; Fiscal Year: 2011..which increases food intake and results in a series of unresolved signaling events in peripheral tissues that lead to increased energy expenditure and decreased body-fat...
- Non-viral Genetic Modification of Antigen-presenting Cells in AllograftsWilson S Meng; Fiscal Year: 2011..Successful completion of the study will lead to improved health outcome of a significant number of patients by decreasing the need for indefinite use of non-..
- Metabolic Engineering of Bacteria for Cancer Immunotherapy by Gamma Delta T CellsCraig T Morita; Fiscal Year: 2013..However, repeat immunizations lead to anergy and deletion of V32V42 T cells...
- The role of Fli1 in T cell function and the pathogenesis of lupusTamara K Nowling; Fiscal Year: 2011..The proposed studies will eventually lead to identifying earlier screening methods and interventions for the treatment of this disease;thus relieving the ..
- Enterococcus faecalis, Colorectal Cancer, and Bystander EffectsMark M Huycke; Fiscal Year: 2012..innate immune responses triggered by redox-active commensal bacteria to produce bystander effects (BSE) that lead to CIN in crypt stem cells...
- Immunomodulatory and regenerative effects of mesenchymal stem cells on allograftsNorma S Kenyon; Fiscal Year: 2013..Aim 2. Determine if intravenous administration of the optimal MSC product can reproducibly lead to reversal of islet allograft rejection and subsequent maintenance of or improvement in islet function and to ..
- Development of Pharmacotherapies for Nicotine AddictionFrank Carroll; Fiscal Year: 2009..In addition, data from our experiments should lead to a better understanding of our MTM and lead to the development of tools to further investigate nicotine addiction...
- Signaling in Thymocyte SelectionGerald R Crabtree; Fiscal Year: 2010..signals the antigen experimental evidence supports a mechanism in which intense signals at the antigen receptor lead to the elimination of clones of T cells bearing receptors binding self to elimination cells bearing receptors ..
- Lead, Cadmium,Arsenic, and cardiovascular risk in childrenEliseo Guallar; Fiscal Year: 2011..It is based upon a growing epidemiological literature, by us and others, indicating that exposure to lead, cadmium, or arsenic increases cardiovascular risk...
- d-Penicillamine Chelation in lead-poisoned Children - A Phase ll/lll TrialMichael Shannon; Fiscal Year: 2007..b>Lead poisoning in children is unequivocally harmful, producing the neurodevelopmental consequences of cognitive losses, ..
- Neuroligin Regulation of Central GABAergic SynapsesZhanyan Fu; Fiscal Year: 2010..These results lead to our main hypothesis that NL2 facilitates GABAergic synapse maturation and accelerates synaptic decay by ..
- High Performance Single Crystal Ultrasound Device for Medical ImagingJian Tian; Fiscal Year: 2009..Piezoelectric single crystals such as lead magnesium niobate - lead titanate (PMN-PT) have superior dielectric and piezoelectric properties suitable for ..