lead

Summary

Summary: A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.19, symbol Pb. (Dorland, 28th)

Top Publications

  1. ncbi Genotoxic effects of lead: an updated review
    Julia García-Lestón
    Department Psychobiology, University of A Coruna, Edificio de Servicios Centrales de Investigación, A Coruna, Spain
    Environ Int 36:623-36. 2010
  2. ncbi Hazards of heavy metal contamination
    Lars Jarup
    Department of Epidemiology and Public Health, Imperial College, London, UK
    Br Med Bull 68:167-82. 2003
  3. ncbi Pseudo-second-order model for lead ion sorption from aqueous solutions onto palm kernel fiber
    Yuh Shan Ho
    Department of Environmental Sciences, College of Environmental Sciences, Peking University, Beijing 100871, People s Republic of China
    J Hazard Mater 129:137-42. 2006
  4. pmc Transcriptome profiling of radish (Raphanus sativus L.) root and identification of genes involved in response to Lead (Pb) stress with next generation sequencing
    Yan Wang
    National Key Laboratory of Crop Genetics and Germplasm Enhancement, Engineering Research Center of Horticultural Crop Germplasm Enhancement and Utilization, Ministry of Education of PR China
    PLoS ONE 8:e66539. 2013
  5. pmc Lead iodide perovskite sensitized all-solid-state submicron thin film mesoscopic solar cell with efficiency exceeding 9%
    Hui Seon Kim
    School of Chemical Engineering and Department of Energy Science, Sungkyunkwan University, Suwon 440 746, Korea
    Sci Rep 2:591. 2012
  6. pmc Outbreak of fatal childhood lead poisoning related to artisanal gold mining in northwestern Nigeria, 2010
    Carrie A Dooyema
    Healthy Homes and Lead Poisoning Prevention Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Health Perspect 120:601-7. 2012
  7. ncbi Very low lead exposures and children's neurodevelopment
    David C Bellinger
    Children s Hospital Boston, Harvard Medical School, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Curr Opin Pediatr 20:172-7. 2008
  8. pmc Influence of prenatal lead exposure on genomic methylation of cord blood DNA
    J Richard Pilsner
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Environ Health Perspect 117:1466-71. 2009
  9. ncbi Heavy metals (lead, cadmium and mercury) in maternal, cord blood and placenta of healthy women
    Iman Al-Saleh
    Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia
    Int J Hyg Environ Health 214:79-101. 2011
  10. ncbi Potassium-lead-switched G-quadruplexes: a new class of DNA logic gates
    Tao Li
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China, and Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
    J Am Chem Soc 131:15082-3. 2009

Detail Information

Publications287 found, 100 shown here

  1. ncbi Genotoxic effects of lead: an updated review
    Julia García-Lestón
    Department Psychobiology, University of A Coruna, Edificio de Servicios Centrales de Investigación, A Coruna, Spain
    Environ Int 36:623-36. 2010
    b>Lead is a ubiquitous toxic heavy metal with unique physical and chemical properties that make it suitable for a great variety of applications...
  2. ncbi Hazards of heavy metal contamination
    Lars Jarup
    Department of Epidemiology and Public Health, Imperial College, London, UK
    Br Med Bull 68:167-82. 2003
    The main threats to human health from heavy metals are associated with exposure to lead, cadmium, mercury and arsenic...
  3. ncbi Pseudo-second-order model for lead ion sorption from aqueous solutions onto palm kernel fiber
    Yuh Shan Ho
    Department of Environmental Sciences, College of Environmental Sciences, Peking University, Beijing 100871, People s Republic of China
    J Hazard Mater 129:137-42. 2006
    The sorption of lead ion onto palm kernel fiber was studied by performing batch kinetic sorption experiments...
  4. pmc Transcriptome profiling of radish (Raphanus sativus L.) root and identification of genes involved in response to Lead (Pb) stress with next generation sequencing
    Yan Wang
    National Key Laboratory of Crop Genetics and Germplasm Enhancement, Engineering Research Center of Horticultural Crop Germplasm Enhancement and Utilization, Ministry of Education of PR China
    PLoS ONE 8:e66539. 2013
    b>Lead (Pb), one of the most toxic heavy metals, can be absorbed and accumulated by plant roots and then enter the food chain resulting in potential health risks for human beings. The radish (Raphanus sativus L...
  5. pmc Lead iodide perovskite sensitized all-solid-state submicron thin film mesoscopic solar cell with efficiency exceeding 9%
    Hui Seon Kim
    School of Chemical Engineering and Department of Energy Science, Sungkyunkwan University, Suwon 440 746, Korea
    Sci Rep 2:591. 2012
    We report on solid-state mesoscopic heterojunction solar cells employing nanoparticles (NPs) of methyl ammonium lead iodide (CH(3)NH(3))PbI(3) as light harvesters...
  6. pmc Outbreak of fatal childhood lead poisoning related to artisanal gold mining in northwestern Nigeria, 2010
    Carrie A Dooyema
    Healthy Homes and Lead Poisoning Prevention Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Health Perspect 120:601-7. 2012
    In May 2010, a team of national and international organizations was assembled to investigate children's deaths due to lead poisoning in villages in northwestern Nigeria.
  7. ncbi Very low lead exposures and children's neurodevelopment
    David C Bellinger
    Children s Hospital Boston, Harvard Medical School, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Curr Opin Pediatr 20:172-7. 2008
    We remain far from achieving the goal of eliminating lead-associated neurodevelopmental morbidities in children...
  8. pmc Influence of prenatal lead exposure on genomic methylation of cord blood DNA
    J Richard Pilsner
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Environ Health Perspect 117:1466-71. 2009
    Fetal lead exposure is associated with adverse pregnancy outcomes and developmental and cognitive deficits; however, the mechanism(s) by which lead-induced toxicity occurs remains unknown...
  9. ncbi Heavy metals (lead, cadmium and mercury) in maternal, cord blood and placenta of healthy women
    Iman Al-Saleh
    Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia
    Int J Hyg Environ Health 214:79-101. 2011
    b>Lead, cadmium and mercury were measured in placental tissue, umbilical cord and maternal blood samples of 1578 women who delivered at the Al-Kharj King Khalid Hospital between 2005 and 2006...
  10. ncbi Potassium-lead-switched G-quadruplexes: a new class of DNA logic gates
    Tao Li
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China, and Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
    J Am Chem Soc 131:15082-3. 2009
    ..Such a K(+)-Pb(2+) switched G-quadruplex, in fact, functions as a two-input INHIBIT logic gate. With the introduction of another input EDTA, this G-quadruplex can be further utilized to construct a reversibly operated IMPLICATION gate...
  11. ncbi The relevance of the individual genetic background for the toxicokinetics of two significant neurodevelopmental toxicants: mercury and lead
    Claudia Gundacker
    Institute of Medical Genetics, Medical University of Vienna, Währinger Strasse 10, A 1090 Vienna, Austria
    Mutat Res 705:130-40. 2010
    The heavy metals mercury and lead are well-known and significant developmental neurotoxicants. This review summarizes the genetic factors that modify their toxicokinetics...
  12. ncbi Time trends in burdens of cadmium, lead, and mercury in the population of northern Sweden
    Maria Wennberg
    Department of Medicine, Skellefteå Hospital, 931 86 Skellefteå, Sweden
    Environ Res 100:330-8. 2006
    ..This study addresses time trends for the three toxic elements cadmium (Cd), mercury (Hg), and lead (Pb)...
  13. pmc Childhood lead poisoning associated with gold ore processing: a village-level investigation-Zamfara State, Nigeria, October-November 2010
    Yi Chun Lo
    Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 120:1450-5. 2012
    During May-June 2010, a childhood lead poisoning outbreak related to gold ore processing was confirmed in two villages in Zamfara State, Nigeria...
  14. ncbi Study on clinical and biochemical toxicity biomarkers in a zinc-lead mine workers
    Ali Akbar Malekirad
    Science and Research Branch, Islamic Azad University IAU, Tehran, Iran
    Toxicol Ind Health 26:331-7. 2010
    The aim of this study was to determine oxidative stress status as well as blood lead (Pb) and zinc (Zn) levels and clinical markers in workers of a Zn-Pb mine...
  15. ncbi Low-level environmental lead exposure and intellectual impairment in children--the current concepts of risk assessment
    Marek Jakubowski
    Department of Chemical Safety, Nofer Institute of Occupational Medicine, Łódź, Poland
    Int J Occup Med Environ Health 24:1-7. 2011
    b>Lead is an environmental contaminant. The majority of epidemiological research on the health effects of lead has been focused on children, because they are more vulnerable to lead than adults...
  16. ncbi Lead
    David C Bellinger
    Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatrics 113:1016-22. 2004
    Children differ from adults in the relative importance of lead sources and pathways, lead metabolism, and the toxicities expressed. The central nervous system effects of lead on children seem not to be reversible...
  17. pmc Association of tobacco and lead exposures with attention-deficit/hyperactivity disorder
    Tanya E Froehlich
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Pediatrics 124:e1054-63. 2009
    The study objective was to determine the independent and joint associations of prenatal tobacco and childhood lead exposures with attention-deficit/hyperactivity disorder (ADHD), as defined by current diagnostic criteria, in a national ..
  18. ncbi Lead neurotoxicity in children: basic mechanisms and clinical correlates
    Theodore I Lidsky
    Center for Trace Element Studies and Environmental Neurotoxicology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Brain 126:5-19. 2003
    b>Lead has been recognized as a poison for millennia and has been the focus of public health regulation in much of the developed world for the better part of the past century...
  19. ncbi Cadmium and lead contamination in japonica rice grains and its variation among the different locations in southeast China
    Fangmin Cheng
    College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310029, PR China
    Sci Total Environ 359:156-66. 2006
    ..sites and a field experiment with 12 cultivars grown at 3 ecologically different locations, Cadmium (Cd) and lead (Pb) contamination in milled rice grains and its variation among different locations were investigated in the area ..
  20. ncbi Blood lead below 0.48 micromol/L (10 microg/dL) and mortality among US adults
    Andy Menke
    Department of Epidemiology, Tulane University SPHTM, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Circulation 114:1388-94. 2006
    Blood lead levels above 0.48 micromol/L (10 microg/dL) in adults have been associated with increased risk of cardiovascular, cancer, and all-cause mortality...
  21. pmc Fetal lead exposure at each stage of pregnancy as a predictor of infant mental development
    Howard Hu
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 114:1730-5. 2006
    The impact of prenatal lead exposure on neurodevelopment remains unclear in terms of consistency, the trimester of greatest vulnerability, and the best method for estimating fetal lead exposure.
  22. ncbi Label-free detection of sub-nanomolar lead(II) ions in aqueous solution using a metal-based luminescent switch-on probe
    Hong Zhang He
    Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    Biosens Bioelectron 41:871-4. 2013
    ..It also exhibits good selectivity for Pb(2+) ions over other heavy metal ions. Furthermore, the application of the assay for the detection of Pb(2+) ions in spiked river water samples has been demonstrated...
  23. pmc Low-level environmental lead exposure and children's intellectual function: an international pooled analysis
    Bruce P Lanphear
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Environ Health Perspect 113:894-9. 2005
    b>Lead is a confirmed neurotoxin, but questions remain about lead-associated intellectual deficits at blood lead levels < 10 microg/dL and whether lower exposures are, for a given change in exposure, associated with greater deficits...
  24. pmc Chronic low-level lead exposure affects the monoaminergic system in the mouse superior olivary complex
    Tyler Fortune
    Center for Environmental Health Sciences, Department of Biomedical and Pharmaceutical Sciences, College of Health Professions and Biomedical Sciences, The University of Montana, Missoula, Montana 59812 1552, USA
    J Comp Neurol 513:542-58. 2009
    Low-level lead (Pb) exposure is associated with behavioral and cognitive dysfunction, but it is not clear how Pb produces these behavioral changes. Pb has been shown to alter auditory temporal processing in both humans and animals...
  25. pmc Associations of early childhood manganese and lead coexposure with neurodevelopment
    Birgit Claus Henn
    Department of Environmental Health, Harvard School of Public Health, 401 Park Dr, Boston, MA 02215, USA
    Environ Health Perspect 120:126-31. 2012
    ..Most toxicologic studies focus on a single agent, although this does not reflect real-world scenarios in which humans are exposed to multiple chemicals...
  26. pmc Secondhand tobacco smoke: a source of lead exposure in US children and adolescents
    Andria Apostolou
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Public Health 102:714-22. 2012
    We evaluated the relationship between secondhand tobacco smoke (SHS) exposure and blood lead levels in US children and adolescents.
  27. ncbi Association of lead, mercury and cadmium with diabetes in the Korean population: the Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2010
    S S Moon
    Department of Internal Medicine, Dongguk University College of Medicine, Gyeongju, South Korea
    Diabet Med 30:e143-8. 2013
    ..We investigated the association of heavy metals, including lead, mercury and cadmium, with diabetes in the Korean population.
  28. ncbi Presynaptic malfunction: the neurotoxic effects of cadmium and lead on the proton gradient of synaptic vesicles and glutamate transport
    Tatiana Borisova
    The Department of Neurochemistry, Palladin Institute of Biochemistry, NAS of Ukraine, 9 Leontovicha Street, Kiev 01601, Ukraine
    Neurochem Int 59:272-9. 2011
    ....
  29. pmc Lead and PCBs as risk factors for attention deficit/hyperactivity disorder
    Paul A Eubig
    Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
    Environ Health Perspect 118:1654-67. 2010
    ..In this review we present evidence that environmental chemicals, particularly polychlorinated biphenyls (PCBs) and lead, are associated with deficits in many neurobehavioral functions that are also impaired in ADHD.
  30. ncbi Lead-induced hypertension: possible role of endothelial factors
    F Khalil-Manesh
    Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048
    Am J Hypertens 6:723-9. 1993
    The results of this study confirm that low lead (0.01%) but not high lead (0.5%) administration results in increased blood pressure in rats treated for up to 12 months...
  31. ncbi The evidence that lead increases the risk for spontaneous abortion
    I Hertz-Picciotto
    University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Ind Med 38:300-9. 2000
    ..occupationally exposed women in several countries, support an increase in pregnancy loss from high maternal lead exposures...
  32. pmc Renal and neurologic effects of cadmium, lead, mercury, and arsenic in children: evidence of early effects and multiple interactions at environmental exposure levels
    Claire de Burbure
    Unit of Industrial Toxicology and Occupational Medicine, Faculty of Medicine, Catholic University of Louvain, Clos Chapelle aux Champs 30, B 1200 Brussels, Belgium
    Environ Health Perspect 114:584-90. 2006
    b>Lead, cadmium, mercury, and arsenic are common environmental pollutants in industrialized countries, but their combined impact on children's health is little known...
  33. pmc Childhood and adult socioeconomic position, cumulative lead levels, and pessimism in later life: the VA Normative Aging Study
    Junenette L Peters
    Department of Environmental Health, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
    Am J Epidemiol 174:1345-53. 2011
    ..There is evidence that individuals with higher lead exposure have poorer health...
  34. ncbi Level of trace elements (copper, zinc, magnesium and selenium) and toxic elements (lead and mercury) in the hair and nail of children with autism
    Malarveni Damodaran Lakshmi Priya
    Department of Biochemistry, Bharathi Women s College, Chennai, 600 108 Tamil Nadu, India
    Biol Trace Elem Res 142:148-58. 2011
    ..elements like copper (Cu), zinc (Zn), magnesium (Mg), and selenium (Se) and toxic elements like mercury (Hg), and lead (Pb) in the hair and nail samples of autistic children and to evaluate whether the level of these elements could be ..
  35. pmc Fibrillization of human tau is accelerated by exposure to lead via interaction with His-330 and His-362
    Hai Li Zhu
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
    PLoS ONE 6:e25020. 2011
    ..b>Lead is a potent neurotoxin for human being especially for the developing children, and Pb(2+) at high concentrations is ..
  36. ncbi Developmental aspects of environmental neurotoxicology: lessons from lead and polychlorinated biphenyls
    Gerhard Winneke
    Division of Neurobehavioral Toxicology, Medical Institute of Environmental Hygiene, Heinrich Heine Universitat, Auf m Hennekamp 50, D 40225, Dusseldorf, Germany
    J Neurol Sci 308:9-15. 2011
    ..However, for only few of these, namely inorganic lead, arsenic, organic mercury and polychlorinated biphenyls (PCBs), human evidence is available to suggest that these ..
  37. pmc Association of blood lead (Pb) and plasma homocysteine: a cross sectional survey in Karachi, Pakistan
    Mohsin Yakub
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    PLoS ONE 5:e11706. 2010
    High blood lead (Pb) and hyperhomocysteinemia have been found to be associated with cardiovascular disease (CVD). Mean blood Pb and mean plasma homocysteine levels have been reported to be high in Pakistani population...
  38. ncbi Perinatal lead and mercury exposure in Austria
    Claudia Gundacker
    Institute of Medical Genetics, Medical University of Vienna, Währinger Strasse 10, 1090 Vienna, Austria
    Sci Total Environ 408:5744-9. 2010
    The heavy metals lead (Pb) and mercury (Hg) are ubiquitous environmental pollutants with high neurotoxic potential...
  39. pmc Relationship of thyroid hormone levels to levels of polychlorinated biphenyls, lead, p,p'- DDE, and other toxicants in Akwesasne Mohawk youth
    Lawrence M Schell
    Department of Anthropology, University at Albany, State University of New York, Albany, New York 12222, USA
    Environ Health Perspect 116:806-13. 2008
    ..Chronic exposure to multiple toxicants is common but difficult to analyze, and most prior studies have focused on adults or newborns, creating a gap in our understanding of multitoxicant effects among adolescents...
  40. pmc Altered myelination and axonal integrity in adults with childhood lead exposure: a diffusion tensor imaging study
    Christopher J Brubaker
    Cincinnati Children s Environmental Health Center at the Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Neurotoxicology 30:867-75. 2009
    Childhood lead exposure is associated with adverse cognitive, neurobehavioral and motor outcomes, suggesting altered brain structure and function...
  41. pmc Lead(II) as a probe for investigating RNA structure in vivo
    Magnus Lindell
    Institute of Cell and Molecular Biology, Biomedical Center, Uppsala University, Sweden
    RNA 8:534-41. 2002
    ..we describe a simple and reliable method for RNA structure determination in vivo, using the divalent ion, lead(II), as a structural probe...
  42. pmc Water arsenic exposure and intellectual function in 6-year-old children in Araihazar, Bangladesh
    Gail A Wasserman
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 115:285-9. 2007
    ..We recently reported results of a cross-sectional investigation of intellectual function in 10-year-olds in Bangladesh, who had been exposed to arsenic from drinking water in their home wells...
  43. ncbi Lead toxicity, a review of the literature. Part 1: Exposure, evaluation, and treatment
    Lyn Patrick
    Altern Med Rev 11:2-22. 2006
    The phasing out of leaded gasoline for transportation vehicles between 1973 and 1995 and the removal of lead from paint by federal mandate by 1978 have resulted in substantial lowering of mean blood lead levels in all segments of the U.S...
  44. pmc Mechanisms of lead-induced hypertension and cardiovascular disease
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, UCI Medical Center, 101 The City Dr, Bldg 53, Rm 125, Rt 81, Orange, CA 92868, USA
    Am J Physiol Heart Circ Physiol 295:H454-65. 2008
    b>Lead is a ubiquitous environmental toxin that is capable of causing numerous acute and chronic illnesses...
  45. pmc Neurotoxic effects and biomarkers of lead exposure: a review
    Talia Sanders
    Molecular Toxicology Research Laboratory, NIH RCMI Center for Environmental Health, College of Science, Engineering, and Technology, Jackson State University, Jackson, MS, USA
    Rev Environ Health 24:15-45. 2009
    b>Lead, a systemic toxicant affecting virtually every organ system, primarily affects the central nervous system, particularly the developing brain...
  46. pmc The role of environmental mercury, lead and pesticide exposure in development of amyotrophic lateral sclerosis
    Frank O Johnson
    Center for Integrative Toxicology and Neuroscience Program and Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, United States
    Neurotoxicology 30:761-5. 2009
    ..been reported, although circumstantial epidemiological evidence has implicated exposure to heavy metals such as lead and mercury, industrial solvents and pesticides especially organophosphates and certain occupations such as playing ..
  47. pmc Mass lead intoxication from informal used lead-acid battery recycling in dakar, senegal
    Pascal Haefliger
    Department of Public Health and Environment, World Health Organization, Geneva, Switzerland
    Environ Health Perspect 117:1535-40. 2009
    ..died from a rapidly progressive central nervous system disease of unexplained origin in a community involved in the recycling of used lead-acid batteries (ULAB) in the suburbs of Dakar, Senegal. We investigated the cause of these deaths.
  48. ncbi Environmental tobacco smoke (ETS) exposure in children with asthma-relation between lead and cadmium, and cotinine concentrations in urine
    Stefan Willers
    Unit of Preventive Medicine, Heart and Lung Center, Lund University Hospital, SE 221 85 Lund, Sweden
    Respir Med 99:1521-7. 2005
    ..The corresponding concentrations of the heavy metals cadmium and lead in dust and urine (U-Cd; U-Pb) were determined in the same samples...
  49. pmc Blood cadmium and lead and chronic kidney disease in US adults: a joint analysis
    Ana Navas-Acien
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Am J Epidemiol 170:1156-64. 2009
    Environmental cadmium and lead exposures are widespread, and both metals are nephrotoxic at high exposure levels...
  50. pmc A critical review of biomarkers used for monitoring human exposure to lead: advantages, limitations, and future needs
    Fernando Barbosa
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Environ Health Perspect 113:1669-74. 2005
    b>Lead concentration in whole blood (BPb) is the primary biomarker used to monitor exposure to this metallic element. The U.S. Centers for Disease Control and Prevention and the World Health Organization define a BPb of 10 microg/dL (0...
  51. ncbi House dust as possible route of environmental exposure to cadmium and lead in the adult general population
    Janneke Hogervorst
    Centrum voor Milieukunde, Limburgs Universitair Centrum, Diepenbeek, Belgium
    Environ Res 103:30-7. 2007
    ..We investigated the relations between biomarkers of exposure to cadmium and lead, and the metal loading rates in house dust in the adult residents of an area with a soil cadmium concentration of > ..
  52. pmc Blood lead level and kidney function in US adolescents: The Third National Health and Nutrition Examination Survey
    Jeffrey J Fadrowski
    Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, MD, USA
    Arch Intern Med 170:75-82. 2010
    Chronic, high-level lead exposure is a known risk factor for kidney disease...
  53. ncbi Blood lead levels of children and its trend in China
    Kangmin He
    Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China
    Sci Total Environ 407:3986-93. 2009
    To evaluate Chinese children's blood lead levels (BLLs) and identify its distribution features, we collected articles on children's BLLs published from Jan, 2004 to Aug, 2007 with sampling time since 2001, by searching Chinese Biomedical ..
  54. pmc Association between blood lead and the risk of amyotrophic lateral sclerosis
    Fang Fang
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Am J Epidemiol 171:1126-33. 2010
    ..a 2003-2007 case-control study including 184 cases and 194 controls to examine the association between blood lead and the risk of amyotrophic lateral sclerosis (ALS) among US veterans and to explore the influence on this ..
  55. ncbi Fetal growth restriction is related to placental levels of cadmium, lead and arsenic but not with antioxidant activities
    Miguel N Llanos
    Laboratory of Nutrition and Metabolic Regulation, Institute of Nutrition and Food Technology INTA, University of Chile, Macul 5540, Casilla 138 11, Santiago, Chile
    Reprod Toxicol 27:88-92. 2009
    ..and arsenic were measured by Instrumental Neutron Activation Analysis (INAA), and iron, copper, cadmium and lead by Atomic Absorption Spectrometry (AAS)...
  56. ncbi Trends in blood lead levels and blood lead testing among US children aged 1 to 5 years, 1988-2004
    Robert L Jones
    Centers for Disease Control and Prevention, National Center for Environmental Health, 4770 Buford Hwy, Atlanta, GA 30341
    Pediatrics 123:e376-85. 2009
    To evaluate trends in children's blood lead levels and the extent of blood lead testing of children at risk for lead poisoning from national surveys conducted during a 16-year period in the United States.
  57. ncbi Exposure to arsenic and lead and neuropsychological development in Mexican children
    J Calderon
    Facultad de Medicina, Universidad Autonoma de San Luis Potosi, Av Venustiano Carranza 2405, 78210 San Luis Potosi, Mexico
    Environ Res 85:69-76. 2001
    This cross-sectional study examined the effects of chronic exposure to lead (Pb), arsenic (AS) and undernutrition on the neuropsychological development of children...
  58. ncbi Co-exposure to environmental lead and manganese affects the intelligence of school-aged children
    Yeni Kim
    Division of Child and Adolescent Psychiatry, Department of Psychiatry and Institute of Human Behavioral Medicine, Seoul National University College of Medicine, 28 YeonGun Dong, Chongno Gu, Seoul, 110 744, Republic of Korea
    Neurotoxicology 30:564-71. 2009
    Exposure to environmental levels of lead (Pb) and manganese (Mn) has been associated with detrimental effects to neurodevelopment...
  59. ncbi Nonlinear association between soil lead and blood lead of children in metropolitan New Orleans, Louisiana: 2000-2005
    Howard W Mielke
    Xavier University of Louisiana, College of Pharmacy, 1 Drexel Drive, New Orleans, Louisiana 70125, USA
    Sci Total Environ 388:43-53. 2007
    Metropolitan New Orleans is unique because it has a universal blood lead (BL) screening dataset (n=55,551) from 2000-2005 spatially coupled with a soil lead (SL) dataset (n=5467) completed in 2000...
  60. ncbi Lead promotes abasic site accumulation and co-mutagenesis in mammalian cells by inhibiting the major abasic endonuclease Ape1
    Daniel R McNeill
    Laboratory of Molecular Gerontology, GRC, National Institute on Aging, IRP, NIH, Baltimore, Maryland 21224 6825, USA
    Mol Carcinog 46:91-9. 2007
    b>Lead is a widespread environmental toxin, found in contaminated water sources, household paints, and certain occupational settings...
  61. pmc Electrochemical microsensors for the detection of cadmium(II) and lead(II) ions in plants
    Olga Krystofova
    Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Zemedelska 1, CZ 613 00 Brno, Czech Republic
    Sensors (Basel) 10:5308-28. 2010
    ..PalmSens) and a homemade micropotentiostat] for easy-to-use and sensitive determination of cadmium(II) and lead(II) ions...
  62. pmc Multiple environmental chemical exposures to lead, mercury and polychlorinated biphenyls among childbearing-aged women (NHANES 1999-2004): Body burden and risk factors
    Marcella Remer Thompson
    Superfund Research Program, Brown University, Providence, Rhode Island, USA
    Environ Res 121:23-30. 2013
    b>Lead, mercury and polychlorinated biphenyls (PCBs) are neurotoxicants with intergenerational health consequences from maternal body burden and gestational exposures...
  63. pmc Prenatal low-level lead exposure and developmental delay of infants at age 6 months (Krakow inner city study)
    Wieslaw Jedrychowski
    Epidemiology and Preventive Medicine, Jagiellonian University, Collegium Medicum, Krakow, Poland
    Int J Hyg Environ Health 211:345-51. 2008
    ..to assess the neurocognitive status of 6-month-old infants whose mothers were exposed to low but varying amounts of lead during pregnancy...
  64. pmc Use of geographic information system technology to aid Health Department decision making about childhood lead poisoning prevention activities
    D B Reissman
    Lead Poisoning Prevention Branch, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Environ Health Perspect 109:89-94. 2001
    ..Control and Prevention recommend that local public health agencies use local data to identify children at risk for lead exposure to ensure that they receive preventive services...
  65. ncbi Disrupted pro- and antioxidative balance as a mechanism of neurotoxicity induced by perinatal exposure to lead
    Irena Baranowska-Bosiacka
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp 72 str, 70 111 Szczecin, Poland
    Brain Res 1435:56-71. 2012
    The aim of this paper was to examine if pre- and neonatal exposure that results in lead (Pb) concentration below 'safe level' (10 μg/dL) in offspring blood may cause disruption of the pro/antioxidant balance in the developing rat brain...
  66. pmc Response inhibition and error monitoring during a visual go/no-go task in inuit children exposed to lead, polychlorinated biphenyls, and methylmercury
    Olivier Boucher
    Centre de Recherche du Centre Hospitalier Universitaire de Québec, Quebec, Canada
    Environ Health Perspect 120:608-15. 2012
    b>Lead (Pb) and polychlorinated biphenyls (PCBs) are neurotoxic contaminants that have been related to impairment in response inhibition.
  67. ncbi Biosorption of cadmium, lead and copper with calcium alginate xerogels and immobilized Fucus vesiculosus
    Y N Mata
    Department of Materials Science and Metallurgical Engineering, Complutense University of Madrid, Ciudad Universitaria s n, 28040 Madrid, Spain
    J Hazard Mater 163:555-62. 2009
    ..The Langmuir maximum biosorption capacity increased twofold for cadmium, 10 times for lead, and decreased by half for copper...
  68. ncbi Environmental lead exposure and progressive renal insufficiency
    J L Lin
    Poison Center and Division of Nephrology, Chang Gung Memorial Hospital, 199, Tung Hwa North Road, Taipei, Taiwan, Republic of China
    Arch Intern Med 161:264-71. 2001
    Several recent studies show that serum creatinine level or creatinine clearance is inversely associated with blood lead levels. However, the studies did not allow direct inferences about causality.
  69. ncbi Lead in edible mushrooms: levels and bioaccumulation factors
    M Angeles García
    Department of Toxicology, Faculty of Veterinary University of Santiago de Compostela, Lugo, Spain
    J Hazard Mater 167:777-83. 2009
    b>Lead content was determined in 238 samples of 28 species of edible mushrooms collected from different sites in the province of Lugo (NW Spain) during 2005 and 2006...
  70. pmc Association between prenatal lead exposure and blood pressure in children
    Aimin Zhang
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109 2029, USA
    Environ Health Perspect 120:445-50. 2012
    b>Lead exposure in adults is associated with hypertension...
  71. ncbi The potential effect of metallothionein 2A -5A/G single nucleotide polymorphism on blood cadmium, lead, zinc and copper levels
    Zeliha Kayaalti
    Ankara University Institute of Forensic Sciences Dikimevi, 06590 Ankara, Turkey
    Toxicol Appl Pharmacol 256:1-7. 2011
    ..This study suggests that having the GG genotype individuals may be more sensitive for the metal toxicity and they should be more careful about protecting their health against the toxic effects of the heavy metals...
  72. ncbi The relationship between blood and serum lead levels in peripartum women and their respective umbilical cords
    Jefferson H Amaral
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Ribeirao Preto, SP, Brazil
    Basic Clin Pharmacol Toxicol 107:971-5. 2010
    Foetal exposure to lead (Pb) during pregnancy is a major problem. However, no previous study has examined whether Pb concentrations in blood (Pb-B) and in serum (Pb-S) from pregnant women correlate with Pb-B and Pb-S in the foetuses...
  73. ncbi Metals and women's health
    M Vahter
    Institute of Environmental Medicine, Karolinska Institutet, Sweden
    Environ Res 88:145-55. 2002
    ..The present work aims at reviewing exposure and health effects of cadmium, nickel, lead, mercury, and arsenic manifested differently in women than in men...
  74. ncbi Environmental lead exposure and progression of chronic renal diseases in patients without diabetes
    Ja Liang Lin
    Division of Nephrology, Chang Gung Memorial Hospital, Lin Kou Medical Center, Medical College of Chang Gung University, Taipei, Taiwan
    N Engl J Med 348:277-86. 2003
    Previous research suggests that environmental lead exposure correlates with age-related decreases in renal function.
  75. pmc Suppression of Chlorella vulgaris growth by cadmium, lead, and copper stress and its restoration by endogenous brassinolide
    Andrzej Bajguz
    Department of Plant Biochemistry and Toxicology, Institute of Biology, University of Bialystok, Swierkowa 20 B, 15 950 Bialystok, Poland
    Arch Environ Contam Toxicol 60:406-16. 2011
    ..vulgaris cultures treated with 10(-8) M brassinolide (BL) were exposed to 10(-6)-10(-4) M heavy metals (cadmium, lead and copper) application...
  76. ncbi Exposure to Pb, Cd, and As mixtures potentiates the production of oxidative stress precursors: 30-day, 90-day, and 180-day drinking water studies in rats
    Margaret H Whittaker
    Toxicology Program, The University of Maryland at Baltimore, Baltimore, MD, USA
    Toxicol Appl Pharmacol 254:154-66. 2011
    ..Interactive effects of lead (Pb), cadmium (Cd) and arsenic (As) were evaluated in 30-, 90-, and 180-day factorial design drinking water studies ..
  77. ncbi Nephrotoxicity of cadmium & lead
    H C Gonick
    Division of Nephrology, West Los Angeles Healthcare Center, Los Angeles, California 90073, USA
    Indian J Med Res 128:335-52. 2008
    Cadmium and lead are divalent cations with a propensity to settle in the proximal tubule of the nephron, leading to nephrotoxicity. The pathophysiological results, however, tend to diverge...
  78. pmc Lead exposure and cardiovascular disease--a systematic review
    Ana Navas-Acien
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Environ Health Perspect 115:472-82. 2007
    This systematic review evaluates the evidence on the association between lead exposure and cardiovascular end points in human populations.
  79. pmc Molecular neurobiology of lead (Pb(2+)): effects on synaptic function
    April P Neal
    Department of Pharmacology and Toxicology, Michigan State University, B307 Life Sciences Building, East Lansing, MI 48824, USA
    Mol Neurobiol 42:151-60. 2010
    b>Lead (Pb(2+)) is a ubiquitous environmental neurotoxicant that continues to threaten public health on a global scale. Epidemiological studies have demonstrated detrimental effects of Pb(2+) on childhood IQ at very low levels of exposure...
  80. pmc The relation of lead neurotoxicity to the event-related potential P3b component in Inuit children from arctic Québec
    Olivier Boucher
    Ecole de Psychologie, Universite Laval, Quebec, Canada
    Neurotoxicology 30:1070-7. 2009
    ..in many experimental paradigms, was measured in Inuit children from Nunavik (Arctic Québec, Canada) to assess lead (Pb) neurotoxicity...
  81. ncbi Potentially toxic metal contamination of urban soils and roadside dust in Shanghai, China
    Guitao Shi
    Key Laboratory of Geographic Information Science of Ministry of Education, East China Normal University, Shanghai 200062, China
    Environ Pollut 156:251-60. 2008
    ....
  82. ncbi Cellular mechanisms of lead neurotoxicity
    Anibal Garza
    Instituto de Fisiologia, Universidad Autonoma de Puebla, Pue, Mexico
    Med Sci Monit 12:RA57-65. 2006
    b>Lead (Pb2+), a heavy metal, has been used by humans for many technological purposes, which is the main reason for its present widespread distribution...
  83. ncbi Lead-induced oxidative stress adversely affects health of the occupational workers
    D A Khan
    Department of Pathology Army Medical College, National University Sciences and Technology, Rawalpindi, Pakistan
    Toxicol Ind Health 24:611-8. 2008
    b>Lead is a persistent toxic metal and associated with impairment of various body functions in occupational workers...
  84. pmc Metallothioneins are required for formation of cross-adaptation response to neurobehavioral toxicity from lead and mercury exposure in nematodes
    Boping Ye
    College of Life Science and Technology, China Pharmaceutical University, Nanjing, China
    PLoS ONE 5:e14052. 2010
    ..Therefore, the normal formation of cross-adaptation response to neurobehavioral toxicity induced by metal exposure may need the enough accumulation of MTs protein in animal tissues...
  85. ncbi The detoxification of lead in Sedum alfredii H. is not related to phytochelatins but the glutathione
    D K Gupta
    Ministry of Education Key Laboratory of Environmental Remediation and Ecosystem Health, Zhejiang University, Hua jian chi Campus, Hangzhou 310029, China
    J Hazard Mater 177:437-44. 2010
    ..These results suggest that enzymatic and non-enzymatic antioxidants play a key role in the detoxification of Pb-induced toxic effects in Sedum alfredii. This plant can be used as an indicator species for Pb contamination...
  86. ncbi Heavy metals exposure and hearing loss in US adolescents
    Josef Shargorodsky
    Channing Laboratory, 181 Longwood Ave, Boston, MA 02115, USA
    Arch Otolaryngol Head Neck Surg 137:1183-9. 2011
    ..Hearing loss is common and, in young persons, can compromise social development and educational achievement. Exposure to heavy metals has been proposed as an important risk factor for hearing loss...
  87. ncbi Longitudinal associations between blood lead concentrations lower than 10 microg/dL and neurobehavioral development in environmentally exposed children in Mexico City
    Martha M Téllez-Rojo
    Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
    Pediatrics 118:e323-30. 2006
    ..that 10 microg/dL, the current Centers for Disease Control and Prevention screening guideline for children's blood lead level, should not be interpreted as a level at which adverse effects do not occur...
  88. ncbi A population-based assessment of blood lead levels in relation to inflammation
    Natthapol Songdej
    Department of Community and Preventive Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Environ Res 110:272-7. 2010
    Some experimental and observational research suggests that inflammation may be an important mediator of lead toxicity. However, lead-induced inflammation has not been well-studied in non-occupationally exposed populations.
  89. ncbi Monitoring of lead, cadmium, chromium and nickel in placenta from an e-waste recycling town in China
    Yongyong Guo
    Analytical Cytology Laboratory, Shantou University Medical College, Guangdong, P R China
    Sci Total Environ 408:3113-7. 2010
    ..from unregulated electronic waste (e-waste) recycling in Guiyu, China, and thus may contribute to the elevation of lead and other heavy metals levels in placenta...
  90. ncbi Lead and bisphenol A concentrations in the Canadian population
    Tracey Bushnik
    Health Analysis Division, Statistics Canada, Ottawa, Ontario K1A0T6
    Health Rep 21:7-18. 2010
    b>Lead is a known toxicant that occurs naturally in the environment. Bisphenol A (BPA) is an industrial chemical used primarily in polycarbonate plastic and epoxy resins...
  91. ncbi Effects of lead exposure on oxidative stress biomarkers and plasma biochemistry in waterbirds in the field
    Monica Martinez-Haro
    Instituto de Investigación en Recursos Cinegéticos CSIC UCLM JCCM, Ronda de Toledo s n, 13071 Ciudad Real, Spain
    Environ Res 111:530-8. 2011
    Medina lagoon in Andalusia has one of the highest densities of spent lead (Pb) shot in Europe...
  92. ncbi The effect of long-term low-dose lead exposure on thyroid function in adolescents
    Bumin Dundar
    Department of Pediatrics, Faculty of Medicine, Suleyman Demirel University, Merkez 32040, Isparta, Turkey
    Environ Res 101:140-5. 2006
    This study investigated blood lead (Pb-B) levels and Pb-B effects on thyroid functions in long-term low-level-lead-exposed male adolescents who work as auto repairers...
  93. pmc Lead exposure: a contributing cause of the current breast cancer epidemic in Nigerian women
    Olusegun I Alatise
    Department of Anatomy and Cell Biology, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Nigeria
    Biol Trace Elem Res 136:127-39. 2010
    ..This suggested that the associated widespread contamination of the soil and of the water supplies by lead (Pb) and other industrial metals was a major contributing cause...
  94. ncbi Bone lead levels and blood pressure endpoints: a meta-analysis
    Ana Navas-Acien
    Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Epidemiology 19:496-504. 2008
    Previous reviews have shown increases in blood pressure and hypertension associated with increases in lead levels in blood...
  95. pmc The influence of age of lead exposure on adult gray matter volume
    Christopher J Brubaker
    Cincinnati Children s Environmental Health Center, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Neurotoxicology 31:259-66. 2010
    Childhood lead exposure is associated with decreased cognitive abilities and executive functioning localized within the prefrontal cortex...
  96. ncbi New and evolving concepts in the neurotoxicology of lead
    L D White
    National Center for Environmental Assessment, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 225:1-27. 2007
    b>Lead (Pb) is a xenobiotic metal with no known essential function in cellular growth, proliferation, or signaling...
  97. ncbi Lead induced oxidative damage and its response to combined administration of alpha-lipoic acid and succimers in rats
    Manisha Pande
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior, India
    Toxicology 177:187-96. 2002
    ..acid (LA) has been reported to be highly effective in improving the thiol capacity of the cells and in reducing lead induced oxidative stress...
  98. ncbi Lead in pharmaceutical products and dietary supplements
    John F Kauffman
    U S Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Sciences, Division of Pharmaceutical Analysis, 1114 Market St, St Louis, MO 63101, USA
    Regul Toxicol Pharmacol 48:128-34. 2007
    The objective of this study is to determine lead concentrations in a variety of widely used pharmaceutical products, and to assess the risk of lead exposure from using these products...
  99. ncbi Lead, zinc, cadmium, mercury, selenium and copper in Greenland caribou and reindeer (Rangifer tarandus)
    P Aastrup
    Department of Arctic Environment, National Environmental Research Institute, Copenhagen, Denmark
    Sci Total Environ 245:149-59. 2000
    ..The levels of lead, zinc, cadmium, mercury, selenium, and copper were determined, and analyzed in relation to location, two seasons, ..
  100. ncbi Environmental exposure to lead, but not other neurotoxic metals, relates to core elements of ADHD in Romanian children: performance and questionnaire data
    Rodica Nicolescu
    Institutul de Sănătate Publică, Str Dr Leonte 1 3, 050463 Bucuresti, Romania
    Environ Res 110:476-83. 2010
    ..features of the attention-deficit hyperactivity disorder (ADHD) have been studied in pediatric environmental lead research...
  101. pmc Biomarkers of lead exposure and DNA methylation within retrotransposons
    Robert O Wright
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 118:790-5. 2010
    ..Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a marker of cumulative exposure, may therefore better predict DNA methylation than does blood lead.

Research Grants68

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..It can lead to macular edema, a swelling of the retina that is a common source of vision loss...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..It can lead to macular edema, a swelling of the retina that is a common source of vision loss...
  3. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  4. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  5. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  6. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  7. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  8. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..care to patients throughout California, providing outreach and education to patients and communities, playing a lead role in national research trials in thalassemia, and enrolling patients from CHRCO in the CDC Thalassemia Universal ..
  9. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
    ..to investigate other liver based diseases such as Wilson's and Alpha-1-antitrypsin deficiency and may even lead to better-humanized models for primary, acute liver failure and viral, alcoholic and autoimmune hepatitis and even ..
  10. Optimization of DNA Repair by Abh8
    Lauren Endres; Fiscal Year: 2013
    ..We expect that the deletion of Abh8-/- in our mouse model will lead to defects in DNA repair and that this will eventually lead to widespread genomic instability and cancer ..
  11. National Network of Libraries of Medicine (NN/LM) Region 2
    Javier Crespo; Fiscal Year: 2010
    ..Collaborations with affiliate network members such as public libraries and community-based organizations often lead to outreach projects with broad community impact. Specifically the contractor shall undertake the following: 1...
  12. National Network of Libraries of Medicine (NN/LM) Region 2
    DENNIS PATTRATH; Fiscal Year: 2010
    ..Collaborations with affiliate network members such as public libraries and community-based organizations often lead to outreach projects with broad community impact. Specifically the contractor shall undertake the following: 1...
  13. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..The long-term objective is to find inhibitors of the PDKs that will lead to development of effective drugs for the treatment of these conditions...
  14. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
    ..are to: (1) design and construct laboratory-scale prototypes to conduct evaluation and trade-off studies that will lead to the selection of a commercial-scale SFS-CFI design to achieve >6 logs of inactivation levels of nonenveloped ..
  15. National Network of Libraries of Medicine - Region 2
    JM J TOOEY; Fiscal Year: 2013
    ..Collaborations with affiliate network members such as public libraries and community-based organizations often lead to outreach projects with broad community impact...
  16. National Network of Libraries of Medicine - Region 2
    JM J TOOEY; Fiscal Year: 2012
    ..Collaborations with affiliate network members such as public libraries and community-based organizations often lead to outreach projects with broad community impact...
  17. National Network of Libraries of Medicine - Region 2
    JM J TOOEY; Fiscal Year: 2011
    ..Collaborations with affiliate network members such as public libraries and community-based organizations often lead to outreach projects with broad community impact...
  18. National Network of Libraries of Medicine (NN/LM) Region 3
    Ruth Holst; Fiscal Year: 2010
    ..Collaborations with affiliate network members such as public libraries and community-based organizations often lead to outreach projects with broad community impact. Specifically the contractor shall undertake the following: 1...
  19. Vaccine Development for Falciparum Malaria in Pregnant Women and Their Offspring
    Ian C Michelow; Fiscal Year: 2013
    ..b>Lead candidate antigens will then be downselected using bioinformatics and surface localization studies, as well as ..
  20. National Network of Libraries of Medicine (NN/LM) Region 3
    Ruth Holst; Fiscal Year: 2009
    ..Collaborations with affiliate network members such as public libraries and community-based organizations often lead to outreach projects with broad community impact. Specifically the contractor shall undertake the following: 1...
  21. Immune Regulation of Bone Homeostasis
    MERVYN NEALE WEITZMANN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Bone fractures resulting from osteoporosis lead to significant health costs, morbidity, loss of mobility, and often mortality in aged individuals...
  22. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia J Savin; Fiscal Year: 2010
    ..cells, its activity in injuring glomeruli, and that fact that antibody to CLC blocks the effect of FSGS plasma lead us to the proposed studies to define its role in this serious kidney disease...
  23. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    ..We also anticipate that falls in cardiac output and renal hypoperfusion will lead to activation of the renin-angiotensin system, the chronic up- regulation of which has been associated with ..
  24. National Network of Libraries of Medicine - Region 3
    Ruth Holst; Fiscal Year: 2013
    ..Collaborations with affiliate network members such as public libraries and community-based organizations often lead to outreach projects with broad community impact...
  25. National Network of Libraries of Medicine - Region 3
    Ruth Holst; Fiscal Year: 2011
    ..Collaborations with affiliate network members such as public libraries and community-based organizations often lead to outreach projects with broad community impact...
  26. National Network of Libraries of Medicine - Region 3
    Ruth Holst; Fiscal Year: 2012
    ..Collaborations with affiliate network members such as public libraries and community-based organizations often lead to outreach projects with broad community impact...
  27. Hypothalamic Orexin Role in Menopause-Associated Hot Flashes and Mood/Sleep Disru
    PHILIP LEE JOHNSON; Fiscal Year: 2013
    ..hot flashes with emphasis on the hypothalamic orexin system;and 7) I will provide mechanistic studies that will lead to a translational clinical protocol finding a novel use of an orexin receptor antagonist submitted for FDA ..
  28. Brain Activation responses in adolescents with genetic predisposition to obesity
    Susan Carnell; Fiscal Year: 2011
    ..in satiety/inhibition of food intake areas, reflecting differences in the processing of food stimuli which may lead to obesity...
  29. H1R Signaling and Immune Deviation in EAE
    Cory Teuscher; Fiscal Year: 2013
    ..Proper folding and cell surface expression of GPCRs is required for ligand binding and signaling. Mutations that lead to improper folding and/or intracellular trafficking comprise the largest class of GPCR mutations that result in ..
  30. Pilot and definitive studies to evaluate Insertional Mutagenesis
    LU TAYLOR; Fiscal Year: 2012
    ..smoke, endotoxin, and allergen) that are known to perturb biologic systems resulting in changes in the airway that lead to the development of chronic airway disease...
  31. Studies to Evaluate the Toxicological Potential of Test Articles
    LU TAYLOR; Fiscal Year: 2010
    ..smoke, endotoxin, and allergen) that are known to perturb biologic systems resulting in changes in the airway that lead to the development of chronic airway disease...
  32. National Network of Libraries of Medicine (NN/LM) region 4
    Claire Hamasu; Fiscal Year: 2010
    ..Collaborations with affiliate network members such as public libraries and community-based organizations often lead to outreach projects with broad community impact. Specifically the contractor shall undertake the following: 1...
  33. Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing
    David M Evans; Fiscal Year: 2012
    ..Loss of the integrity of large portions of the skin as a result of wounds and wound-related infection may lead to major disability or even death. Every year in the United States more than 1.25 million people suffer burns and 6...
  34. Enhanced iron removal with peptide linked chelators targeted to ferritin
    Elizabeth C Theil; Fiscal Year: 2010
    ..the genetic anemias, Sickle Cell Disease (SCD) and the Thalassemias (THL), because the regular blood transfusions, lead to accumulations of toxic, sometime fatal amounts of iron that must be removed...
  35. Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure
    John A Butera; Fiscal Year: 2013
    ..This would set the stage for a final lead optimization campaign focused on identifying pre- clinical leads with well-balanced in vivo PK parameters during an ..
  36. National Network of Libraries of Medicine (NN/LM) region 4
    Claire Hamasu; Fiscal Year: 2009
    ..Collaborations with affiliate network members such as public libraries and community-based organizations often lead to outreach projects with broad community impact. Specifically the contractor shall undertake the following: 1...
  37. Principles of Therapy in Cerebellar Disease: Explorations in Ion Channel Mutants
    JOHN SAMUEL STAHL; Fiscal Year: 2013
    ..The search for better treatments would be aided by a better understanding of how specific diseases lead to the symptoms of cerebellar disease, and the mechanisms by which the drugs we do have produce their benefits...
  38. Tyrosine Availability Influences Mesocortico-Limbic Catecholamines
    GEORGE EUGENE JASKIW; Fiscal Year: 2012
    ..This would lead to periods of abnormally high and abnormally low tyrosine in the brain...
  39. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2013
    ..the mechanisms of air pollution exposure on obesity development and associated vascular dysfunction, which may lead to the new policies/interventions in greener energy plants and automobiles, stricter air quality standards, and ..
  40. National Network of Libraries of Medicine (NN/LM) Region 5
    MICHELLE MALIZIA; Fiscal Year: 2010
    ..Collaborations with affiliate network members such as public libraries and community-based organizations often lead to outreach projects with broad community impact. Specifically the contractor shall undertake the following: 1...
  41. Optimized Growth Media to Detect Intracellular Bacteria Implicated in Chronic Dis
    PATRICIA MASCARELLI; Fiscal Year: 2011
    ..Our expectation is that the development of this testing platform will lead to medical breakthroughs in the diagnosis and treatment of chronic disease and will provide extensive savings in ..
  42. Effects of Testosterone and Genetic Factors on Psychological and Motor Function i
    NICOLE RENEE TARTAGLIA; Fiscal Year: 2013
    ..We hypothesize that testosterone therapy initiated in early puberty in KS/XXY will lead to improvements in executive function, psychosocial functioning, and motor skills, while externalizing behaviors ..
  43. Targeting Galectin-3 with novel drugs for treatment of eczema
    Fu Tong Liu; Fiscal Year: 2010
    ..We hope the proposed studies will definitively validate galectin-3 as a target for treating atopic dermatitis and lead to the development of a novel therapy for this disease.
  44. Reactive (AA)Amyloidosis
    Merrill D Benson; Fiscal Year: 2013
    ..These fibril deposits then compromise normal tissue function and lead to progressive organ failure...
  45. Retinoid and Carotenoid Depletion in Patients at High-Risk for Liver Cancer
    Peter H Gann; Fiscal Year: 2010
    ..Completion of the proposed work will lead directly to full-scale proposals for Phase II trials in CLD patients, with tissue endpoints and either dietary or ..
  46. National Network of Libraries of Medicine (NN/LM) Region 5
    MICHELLE MALIZIA; Fiscal Year: 2009
    ..Collaborations with affiliate network members such as public libraries and community-based organizations often lead to outreach projects with broad community impact. Specifically the contractor shall undertake the following: 1...
  47. National Network of Libraries of Medicine (NN/LM) Region 6
    CATHY BURROUGHS; Fiscal Year: 2009
    ..Collaborations with affiliate network members such as public libraries and community-based organizations often lead to outreach projects with broad community impact. Specifically the contractor shall undertake the following: 1...
  48. Structure and function of urea transporters
    Ming Zhou; Fiscal Year: 2013
    ..relationships of mammalian UT in an atomic-resolution, three-dimensional context which eventually we hope will lead to the development of new therapeutic reagents...
  49. National Network of Libraries of Medicine (NN/LM) Region 7
    TAMARA COMBS; Fiscal Year: 2010
    ..Collaborations with affiliate network members such as public libraries and community-based organizations often lead to outreach projects with broad community impact. Specifically the contractor shall undertake the following: 1...
  50. Cystathionine beta synthase (CBS) and angiogenesis
    Priyabrata Mukherjee; Fiscal Year: 2013
    ..impairment of the transsulfuration pathway via pharmacological inhibition or genetic deletion/mutation of CBS may lead to, a) hyperhomocysteninemia (HHcy);b) reduction in cellular glutathione GSH level due to lack of availability of ..
  51. Discovery of Small Molecule MBT Domain Antagonists
    STEPHEN VERNON FRYE; Fiscal Year: 2010
    ..of these modifications create a binding site to recruit other proteins which can 'read'these marks and lead to cell-type and environmentally appropriate gene expression or repression...
  52. Development of VN/14-1 and Related Analogs for Breast Cancer Therapy
    VINCENT COLLINS OFUKA NJAR; Fiscal Year: 2013
    ..Our lead compound, 4-(1)-(1H-imidazol-1-yl)-(E)-retinoic acid (VN/14-1) exhibits exceptional anti-tumor efficacy in several ..
  53. ROLE OF Rac AND REACTIVE OXYGEN SPECIES IN KAPOSI'S SARCOMA VIRAL ONCOGENESIS
    Enrique A Mesri; Fiscal Year: 2013
    ..The identification of human and viral genes that are the cause of KS carcinogenesis is important because it could lead to the identification of new therapeutic targets...
  54. Neurobehavioral Correlates of Familial/genetic obesity risk in adolescents
    Susan Carnell; Fiscal Year: 2013
    ..in satiety/inhibition of food intake areas, reflecting differences in the processing of food stimuli which may lead to obesity...
  55. Role of Txnip in adapting fuel metabolism to nutritional state
    SIMON HUI; Fiscal Year: 2013
    ..Results of this proposed research will provide fundamental information that may lead to better prevention and/or therapeutics for diabetes and cardiovascular disease in humans.
  56. Impact of the P479L Variant in CPT1A on Infant Mortality in Alaska
    David M Koeller; Fiscal Year: 2011
    ..Like other disorders of fatty acid oxidation, CPT1A deficiency can lead to sudden infant death...
  57. Role of SCD1 and Dietary Methionine Restriction on Energy Homeostasis
    ERIC PAUL PLAISANCE; Fiscal Year: 2011
    ..which increases food intake and results in a series of unresolved signaling events in peripheral tissues that lead to increased energy expenditure and decreased body-fat...
  58. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
    ..Successful completion of the study will lead to improved health outcome of a significant number of patients by decreasing the need for indefinite use of non-..
  59. Metabolic Engineering of Bacteria for Cancer Immunotherapy by Gamma Delta T Cells
    Craig T Morita; Fiscal Year: 2013
    ..However, repeat immunizations lead to anergy and deletion of V32V42 T cells...
  60. The role of Fli1 in T cell function and the pathogenesis of lupus
    Tamara K Nowling; Fiscal Year: 2011
    ..The proposed studies will eventually lead to identifying earlier screening methods and interventions for the treatment of this disease;thus relieving the ..
  61. Enterococcus faecalis, Colorectal Cancer, and Bystander Effects
    Mark M Huycke; Fiscal Year: 2012
    ..innate immune responses triggered by redox-active commensal bacteria to produce bystander effects (BSE) that lead to CIN in crypt stem cells...
  62. Immunomodulatory and regenerative effects of mesenchymal stem cells on allografts
    Norma S Kenyon; Fiscal Year: 2013
    ..Aim 2. Determine if intravenous administration of the optimal MSC product can reproducibly lead to reversal of islet allograft rejection and subsequent maintenance of or improvement in islet function and to ..
  63. Development of Pharmacotherapies for Nicotine Addiction
    Frank Carroll; Fiscal Year: 2009
    ..In addition, data from our experiments should lead to a better understanding of our MTM and lead to the development of tools to further investigate nicotine addiction...
  64. Signaling in Thymocyte Selection
    Gerald R Crabtree; Fiscal Year: 2010
    ..signals the antigen experimental evidence supports a mechanism in which intense signals at the antigen receptor lead to the elimination of clones of T cells bearing receptors binding self to elimination cells bearing receptors ..
  65. Lead, Cadmium,Arsenic, and cardiovascular risk in children
    Eliseo Guallar; Fiscal Year: 2011
    ..It is based upon a growing epidemiological literature, by us and others, indicating that exposure to lead, cadmium, or arsenic increases cardiovascular risk...
  66. d-Penicillamine Chelation in lead-poisoned Children - A Phase ll/lll Trial
    Michael Shannon; Fiscal Year: 2007
    ..b>Lead poisoning in children is unequivocally harmful, producing the neurodevelopmental consequences of cognitive losses, ..
  67. Neuroligin Regulation of Central GABAergic Synapses
    Zhanyan Fu; Fiscal Year: 2010
    ..These results lead to our main hypothesis that NL2 facilitates GABAergic synapse maturation and accelerates synaptic decay by ..
  68. High Performance Single Crystal Ultrasound Device for Medical Imaging
    Jian Tian; Fiscal Year: 2009
    ..Piezoelectric single crystals such as lead magnesium niobate - lead titanate (PMN-PT) have superior dielectric and piezoelectric properties suitable for ..