Summary: A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.

Top Publications

  1. pmc Insights into the oxidative degradation of cellulose by a copper metalloenzyme that exploits biomass components
    R Jason Quinlan
    Novozymes, Inc, Davis, CA 95618, USA
    Proc Natl Acad Sci U S A 108:15079-84. 2011
  2. doi Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs
    Wan Seob Cho
    Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    Nanotoxicology 6:22-35. 2012
  3. pmc Copper homeostasis in Salmonella is atypical and copper-CueP is a major periplasmic metal complex
    Deenah Osman
    Life Sciences, Michael Smith Building, University of Manchester, United Kingdom
    J Biol Chem 285:25259-68. 2010
  4. doi Copper toxicity and the origin of bacterial resistance--new insights and applications
    Christopher L Dupont
    Microbial and Environmental Genomics, J Craig Venter Institute, San Diego, CA, USA
    Metallomics 3:1109-18. 2011
  5. pmc Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells
    P Liu
    Research Institute in Healthcare Science, School of Applied Sciences, University of Wolverhampton, Wolverhampton, UK
    Br J Cancer 107:1488-97. 2012
  6. ncbi The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A
    T Tsukihara
    Institute for Protein Research, Osaka University, Suita, Japan
    Science 272:1136-44. 1996
  7. pmc Copper homeostasis at the host-pathogen interface
    Victoria Hodgkinson
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 287:13549-55. 2012
  8. doi Copper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparticles and carbon nanotubes
    Hanna L Karlsson
    Department of Biosciences and Nutrition at Novum, Karolinska Institutet, Stockholm, Sweden
    Chem Res Toxicol 21:1726-32. 2008
  9. pmc SQUAMOSA Promoter Binding Protein-Like7 Is a Central Regulator for Copper Homeostasis in Arabidopsis
    Hiroaki Yamasaki
    Graduate School of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    Plant Cell 21:347-61. 2009
  10. pmc MicroRNA-mediated systemic down-regulation of copper protein expression in response to low copper availability in Arabidopsis
    Salah E Abdel-Ghany
    Biology Department and Program in Molecular Plant Biology, Colorado State University, Fort Collins, Colorado 80523, USA
    J Biol Chem 283:15932-45. 2008

Detail Information

Publications395 found, 100 shown here

  1. pmc Insights into the oxidative degradation of cellulose by a copper metalloenzyme that exploits biomass components
    R Jason Quinlan
    Novozymes, Inc, Davis, CA 95618, USA
    Proc Natl Acad Sci U S A 108:15079-84. 2011
    ..Here we show that GH61 enzymes are a unique family of copper-dependent oxidases...
  2. doi Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs
    Wan Seob Cho
    Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    Nanotoxicology 6:22-35. 2012
    Abstract Nickel, zinc, and copper oxide nanoparticles (NiONP, ZnONP, and CuONP) and their aqueous extracts (AEs) were applied to A549 lung epithelial cells to determine the cytotoxicity, IL-8 production, and activation of transcription ..
  3. pmc Copper homeostasis in Salmonella is atypical and copper-CueP is a major periplasmic metal complex
    Deenah Osman
    Life Sciences, Michael Smith Building, University of Manchester, United Kingdom
    J Biol Chem 285:25259-68. 2010
    ..has two metal-transporting P(1)-type ATPases whose actions largely overlap with respect to growth in elevated copper. Mutants lacking both ATPases over-accumulate copper relative to wild-type or either single mutant...
  4. doi Copper toxicity and the origin of bacterial resistance--new insights and applications
    Christopher L Dupont
    Microbial and Environmental Genomics, J Craig Venter Institute, San Diego, CA, USA
    Metallomics 3:1109-18. 2011
    ..Based on geochemical models, copper became much more bioavailable with the advent of an oxidizing atmosphere...
  5. pmc Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells
    P Liu
    Research Institute in Healthcare Science, School of Applied Sciences, University of Wolverhampton, Wolverhampton, UK
    Br J Cancer 107:1488-97. 2012
    ..In this study, the effect of DS and combination of DS and gemcitabine (dFdC) on GBM cells and GBM stem-like cells was investigated...
  6. ncbi The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A
    T Tsukihara
    Institute for Protein Research, Osaka University, Suita, Japan
    Science 272:1136-44. 1996
    ..the other, five phosphatidyl ethanolamines, three phosphatidyl glycerols and two cholates, two hemes A, and three copper, one magnesium, and one zinc...
  7. pmc Copper homeostasis at the host-pathogen interface
    Victoria Hodgkinson
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 287:13549-55. 2012
    The trace element copper is indispensable for all aerobic life forms. Its ability to cycle between two oxidation states, Cu(1+) and Cu(2+), has been harnessed by a wide array of metalloenzymes that catalyze electron transfer reactions...
  8. doi Copper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparticles and carbon nanotubes
    Hanna L Karlsson
    Department of Biosciences and Nutrition at Novum, Karolinska Institutet, Stockholm, Sweden
    Chem Res Toxicol 21:1726-32. 2008
    ..The effects were not explained by soluble metal impurities. In conclusion, this study highlights the in vitro toxicity of CuO nanoparticles...
  9. pmc SQUAMOSA Promoter Binding Protein-Like7 Is a Central Regulator for Copper Homeostasis in Arabidopsis
    Hiroaki Yamasaki
    Graduate School of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    Plant Cell 21:347-61. 2009
    Expression of miR398 is induced in response to copper deficiency and is involved in the degradation of mRNAs encoding copper/zinc superoxide dismutase in Arabidopsis thaliana...
  10. pmc MicroRNA-mediated systemic down-regulation of copper protein expression in response to low copper availability in Arabidopsis
    Salah E Abdel-Ghany
    Biology Department and Program in Molecular Plant Biology, Colorado State University, Fort Collins, Colorado 80523, USA
    J Biol Chem 283:15932-45. 2008
    In plants, copper is an essential micronutrient required for photosynthesis. Two of the most abundant copper proteins, plastocyanin and copper/zinc superoxide dismutase, are found in chloroplasts...
  11. pmc The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity
    Lee Macomber
    Department of Microbiology, University of Illinois, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 106:8344-9. 2009
    Excess copper is poisonous to all forms of life, and copper overloading is responsible for several human pathologic processes. The primary mechanisms of toxicity are unknown...
  12. pmc A role for the ATP7A copper-transporting ATPase in macrophage bactericidal activity
    Carine White
    Department of Nutritional Sciences, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 284:33949-56. 2009
    b>Copper is an essential micronutrient that is necessary for healthy immune function...
  13. ncbi Transition metal speciation in the cell: insights from the chemistry of metal ion receptors
    Lydia A Finney
    Department of Chemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Il 60208 3113, USA
    Science 300:931-6. 2003
    ..The different coordination numbers, types of coordinating residues, and solvent accessibilities of these sites are providing insight into the inorganic chemistry of the cytoplasm...
  14. ncbi Susceptibility constants of Escherichia coli and Bacillus subtilis to silver and copper nanoparticles
    Ki Young Yoon
    Department of Mechanical Engineering, Yonsei University, 120 749 Seoul, Republic of Korea
    Sci Total Environ 373:572-5. 2007
    ..susceptibility constants were defined and used to evaluate the antimicrobial characteristics of silver and copper nanoparticles against Escherichia coli and Bacillus subtilis. Reaction of copper nanoparticles of 100 nm with B...
  15. pmc Acute toxicity and gastroprotection studies of a new schiff base derived copper (II) complex against ethanol-induced acute gastric lesions in rats
    Maryam Hajrezaie
    Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    PLoS ONE 7:e51537. 2012
    b>Copper is an essential element in various metabolisms. The investigation was carried out to evaluate acute gastroprotective effects of the Copper (II) complex against ethanol-induced superficial hemorrhagic mucosal lesions in rats.
  16. pmc Metallic copper as an antimicrobial surface
    Gregor Grass
    Dept of Clinical Pharmacology, University of Bern, Murtenstrasse 35, 3010 Bern, Switzerland
    Appl Environ Microbiol 77:1541-7. 2011
    Bacteria, yeasts, and viruses are rapidly killed on metallic copper surfaces, and the term "contact killing" has been coined for this process...
  17. pmc Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors
    Haitao You
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada T2N 4N1
    Proc Natl Acad Sci U S A 109:1737-42. 2012
    ..Reducing copper availability by specific chelators (bathocuproine disulfonate, cuprizone) induced nondesensitizing NMDAR currents ..
  18. doi Expression changes of dopaminergic system-related genes in PC12 cells induced by manganese, silver, or copper nanoparticles
    Jianyong Wang
    Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079 9502, USA
    Neurotoxicology 30:926-33. 2009
    ..This study was conducted to investigate the potential neurotoxicity of manganese (Mn), silver (Ag), and copper (Cu) nanoparticles using the dopaminergic neuronal cell line, PC12...
  19. doi Diagnosis and treatment of Wilson disease: an update
    Eve A Roberts
    Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada
    Hepatology 47:2089-111. 2008
  20. doi Laccases: a never-ending story
    Paola Giardina
    Dipartimento di Chimica Organica e Biochimica, Complesso Universitario Monte S Angelo, 80126 Naples, Italy
    Cell Mol Life Sci 67:369-85. 2010
    ..Attention has also been paid to the properties of enzymes endowed with unique characteristics and to fungal laccase multigene families and their organization...
  21. pmc Laboratory evolution of copper tolerant yeast strains
    Giusy Manuela Adamo
    Dipartimento di Biotecnologie e Bioscienze, Universita degli Studi di Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Microb Cell Fact 11:1. 2012
    Yeast strains endowed with robustness towards copper and/or enriched in intracellular Cu might find application in biotechnology processes, among others in the production of functional foods...
  22. pmc Cyanobacterial metallochaperone inhibits deleterious side reactions of copper
    Steve Tottey
    Department of Chemistry, Biophysical Sciences Institute, School of Biological and Biomedical Sciences, University of Durham, Durham DH1 3LE, United Kingdom
    Proc Natl Acad Sci U S A 109:95-100. 2012
    b>Copper metallochaperones supply copper to cupro-proteins through copper-mediated protein-protein-interactions and it has been hypothesized that metallochaperones thereby inhibit copper from causing damage en route...
  23. pmc Transcriptome sequencing identifies SPL7-regulated copper acquisition genes FRO4/FRO5 and the copper dependence of iron homeostasis in Arabidopsis
    Maria Bernal
    Department of Plant Physiology, Ruhr University Bochum, D 44801 Bochum, Germany
    Plant Cell 24:738-61. 2012
    The transition metal copper (Cu) is essential for all living organisms but is toxic when present in excess...
  24. ncbi Demonstration of a hyperglycemia-driven pathogenic abnormality of copper homeostasis in diabetes and its reversibility by selective chelation: quantitative comparisons between the biology of copper and eight other nutritionally essential elements in norma
    Garth J S Cooper
    School of Biological Sciences, Faculty of Science, University of Auckland, Auckland, New Zealand
    Diabetes 54:1468-76. 2005
    ..We suggest that cardiovascular complications in diabetes might be better controlled by therapeutic strategies that focus on lowering plasma glucose and loosely bound systemic Cu(II)...
  25. ncbi Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR
    Anita Changela
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, 2205Tech Drive, Evanston, IL 60208, USA
    Science 301:1383-7. 2003
    The earliest of a series of copper efflux genes in Escherichia coli are controlled by CueR, a member of the MerR family of transcriptional activators...
  26. doi The cop operon is required for copper homeostasis and contributes to virulence in Streptococcus pneumoniae
    Sulman Shafeeq
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    Mol Microbiol 81:1255-70. 2011
    High levels of copper are toxic and therefore bacteria must limit free intracellular levels to prevent cellular damage...
  27. doi New developments in the regulation of intestinal copper absorption
    Peter V E van den Berghe
    Department of Metabolic and Endocrine Diseases, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands
    Nutr Rev 67:658-72. 2009
    The transition metal copper is an essential trace element involved in many enzymatic processes that require redox-chemistry. The redox-activity of copper is potentially harmful...
  28. pmc Molecular analysis of the copper-transporting efflux system CusCFBA of Escherichia coli
    Sylvia Franke
    Molekulare Mikrobiologie, Institut fur Mikrobiologie, Martin Luther Universitat Halle Wittenberg, 06099 Halle, Germany
    J Bacteriol 185:3804-12. 2003
    The cus determinant of Escherichia coli encodes the CusCFBA proteins that mediate resistance to copper and silver by cation efflux. CusA and CusB were essential for copper resistance, and CusC and CusF were required for full resistance...
  29. pmc Genes involved in copper homeostasis in Escherichia coli
    G Grass
    Department of Soil, Water, and Environmental Science, University of Arizona, Tucson, Arizona 85721, USA
    J Bacteriol 183:2145-7. 2001
    Recently, genes for two copper-responsive regulatory systems were identified in the Escherichia coli chromosome...
  30. ncbi Selective divalent copper chelation for the treatment of diabetes mellitus
    G J S Cooper
    Room 1 004, AV Hill Building, School of Biomedicine, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Curr Med Chem 19:2828-60. 2012 such diseases, these two mechanisms are likely to occur as manifestations of a single underlying disturbance of copper regulation. Copper is an essential but highly-toxic trace metal that is closely regulated in biological systems...
  31. pmc CopA: An Escherichia coli Cu(I)-translocating P-type ATPase
    C Rensing
    Department of Biochemistry and Molecular Biology, Wayne State University, School of Medicine, Detroit, MI 48201, USA
    Proc Natl Acad Sci U S A 97:652-6. 2000
    The copA gene product, a putative copper-translocating P-type ATPase, has been shown to be involved in copper resistance in Escherichia coli. The copA gene was disrupted by insertion of a kanamycin gene through homologous recombination...
  32. ncbi Identification and functional expression of HAH1, a novel human gene involved in copper homeostasis
    L W Klomp
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 272:9221-6. 1997
    ..was isolated, which encodes a protein with 47% amino acid identity to Atx1p including conservation of the MTCXGC copper-binding domain. RNA blot analysis using this cDNA identified an abundant 0...
  33. ncbi Role of copper in human neurological disorders
    Vishal Desai
    Unit on Pediatric Genetics, Program in Molecular Medicine, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Am J Clin Nutr 88:855S-8S. 2008
    b>Copper is a trace element present in all tissues and is required for cellular respiration, peptide amidation, neurotransmitter biosynthesis, pigment formation, and connective tissue strength...
  34. doi Copper redistribution in murine macrophages in response to Salmonella infection
    Maud E S Achard
    School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, Australia
    Biochem J 444:51-7. 2012
    ..The present study investigated the role of copper in mouse macrophage responses to Salmonella enterica sv. Typhimurium...
  35. pmc Advances in the understanding of mammalian copper transporters
    Yanfang Wang
    Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
    Adv Nutr 2:129-37. 2011
    b>Copper (Cu) is an essential micronutrient. Its ability to exist in 2 oxidation states (Cu(1+) and Cu(2+)) allows it to function as an enzymatic cofactor in hydrolytic, electron transfer, and oxygen utilization reactions...
  36. pmc Resistance mechanisms of Mycobacterium tuberculosis against phagosomal copper overload
    Jennifer L Rowland
    Department of Microbiology, University of Alabama at Birmingham, 609 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, AL 35294, USA
    Tuberculosis (Edinb) 92:202-10. 2012
    ..In this regard, copper homeostasis mechanisms are particularly interesting, because copper is an important element for bacterial growth, ..
  37. pmc Copper in microbial pathogenesis: meddling with the metal
    Marie I Samanovic
    Department of Microbiology, New York University School of Medicine, 550 First Avenue, Medical Science Building 236, New York, NY 10016, USA
    Cell Host Microbe 11:106-15. 2012
    Transition metals such as iron, zinc, copper, and manganese are essential for the growth and development of organisms ranging from bacteria to mammals...
  38. pmc Iron, zinc and copper in the Alzheimer's disease brain: a quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion
    Matthew Schrag
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, CA, USA
    Prog Neurobiol 94:296-306. 2011
    ..Although questioned by some, brain copper, zinc, and particularly iron overload are widely accepted features of AD which have led to the hypothesis that ..
  39. doi microRNA-directed cleavage and translational repression of the copper chaperone for superoxide dismutase mRNA in Arabidopsis
    Linda Beauclair
    Institut Jean Pierre Bourgin, UMR1318 INRA AgroParisTech, INRA Centre de Versailles Grignon, Route de St Cyr, F 78026 Versailles, France
    Plant J 62:454-62. 2010
    microRNA398 (miR398) is a conserved miRNA of plants that targets two of the three copper/zinc superoxide dismutases (SOD) of Arabidopsis (CSD1 and CSD2) by triggering cleavage or inhibiting translation of their mRNAs...
  40. ncbi Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity
    Di Chen
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 66:10425-33. 2006
    Disulfiram (DSF), a member of the dithiocarbamate family capable of binding copper and an inhibitor of aldehyde dehydrogenase, is currently being used clinically for the treatment of alcoholism...
  41. ncbi Regulation of copper homeostasis by micro-RNA in Arabidopsis
    Hiroaki Yamasaki
    Graduate School of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashiku, Fukuoka 812 8581, Japan
    J Biol Chem 282:16369-78. 2007
    Major copper proteins in the cytoplasm of plant cells are plastocyanin, copper/zinc superoxide dismutase, and cytochrome c oxidase...
  42. doi Clinical utility of copper, ceruloplasmin, and metallothionein plasma determinations in human neurodegenerative patients and their first-degree relatives
    Nathalie Arnal
    INIBIOLP Instituto de Investigac iones Bioquímicas de La Plata, CCT La Plata, CONICET UNLP, Catedra de Bioquimica y Biologia Molecular, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, 60 y 120 1900 La Plata, Argentina
    Brain Res 1319:118-30. 2010
    The concentration of plasma copper, ceruloplasmin (CRP), non-ceruloplasmin-bound Cu (NCBC), and metallothioneins (MTs) were studied as putative biomarkers for neurodegenerative diseases in patients and in their first-degree relatives...
  43. ncbi Excess of nonceruloplasmin serum copper in AD correlates with MMSE, CSF [beta]-amyloid, and h-tau
    R Squitti
    AFaR Department of Neuroscience, Hospital Fatebenefratelli, Rome, Italy
    Neurology 67:76-82. 2006
    To assess whether serum copper in Alzheimer disease (AD) correlates with cognitive scores, beta-amyloid, and other CSF markers of neurodegeneration.
  44. pmc Copper metallochaperones
    Nigel J Robinson
    Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, NE2 4HH, United Kingdom
    Annu Rev Biochem 79:537-62. 2010
    The current state of knowledge on how copper metallochaperones support the maturation of cuproproteins is reviewed...
  45. doi Toxicity of nanosized and bulk ZnO, CuO and TiO2 to bacteria Vibrio fischeri and crustaceans Daphnia magna and Thamnocephalus platyurus
    Margit Heinlaan
    National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, Tallinn 12618, Estonia
    Chemosphere 71:1308-16. 2008
    ..This is the first evaluation of ZnO, CuO and TiO2 toxicity to V. fischeri and T. platyurus. For nano ZnO and nano CuO this is also a first study for D. magna...
  46. doi Oxidative cleavage of cellulose by fungal copper-dependent polysaccharide monooxygenases
    William T Beeson
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    J Am Chem Soc 134:890-2. 2012
    Fungal-derived, copper-dependent polysaccharide monooxygenases (PMOs), formerly known as GH61 proteins, have recently been shown to catalyze the O(2)-dependent oxidative cleavage of recalcitrant polysaccharides...
  47. doi Mechanisms for copper acquisition, distribution and regulation
    Byung Eun Kim
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Research Drive, Levine Science Research Center, C351, Durham, North Carolina 27710, USA
    Nat Chem Biol 4:176-85. 2008
    b>Copper (Cu) is a redox-active metal ion essential for most aerobic organisms...
  48. pmc Synthesis, characterization, and antimicrobial properties of copper nanoparticles
    Muhammad Sani Usman
    Department of Chemistry, Faculty of Science, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia
    Int J Nanomedicine 8:4467-79. 2013
    b>Copper nanoparticle synthesis has been gaining attention due to its availability. However, factors such as agglomeration and rapid oxidation have made it a difficult research area...
  49. doi Strain specificity in antimicrobial activity of silver and copper nanoparticles
    Jayesh P Ruparelia
    Centre for Environmental Science and Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, India
    Acta Biomater 4:707-16. 2008
    The antimicrobial properties of silver and copper nanoparticles were investigated using Escherichia coli (four strains), Bacillus subtilis and Staphylococcus aureus (three strains)...
  50. doi Antitumor activity of metal-chelating compound Dp44mT is mediated by formation of a redox-active copper complex that accumulates in lysosomes
    David B Lovejoy
    Department of Pathology, University of Sydney, Sydney, New South Wales, Australia
    Cancer Res 71:5871-80. 2011
    ..Here, we report that Dp44mT targets lysosome integrity through copper binding...
  51. pmc Phosphorescent sensor for robust quantification of copper(II) ion
    Youngmin You
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 133:11488-91. 2011
    ..exhibits concomitant changes in its phosphorescence intensity ratio and phosphorescence lifetime in response to copper(II) ion...
  52. ncbi The copper chaperone for superoxide dismutase
    V C Culotta
    Division of Toxicological Sciences, Department of Environmental Health Sciences, Johns Hopkins University School of Public Health, Baltimore, Maryland 21205, USA
    J Biol Chem 272:23469-72. 1997
    b>Copper is distributed to distinct localizations in the cell through diverse pathways...
  53. pmc NMR structure of a lytic polysaccharide monooxygenase provides insight into copper binding, protein dynamics, and substrate interactions
    Finn L Aachmann
    Department of Biotechnology, NOBIOPOL, Norwegian University of Science and Technology, NO 7491 Trondheim, Norway
    Proc Natl Acad Sci U S A 109:18779-84. 2012
    ..Cyanide, a mimic of molecular oxygen, was found to bind to the metal ion only. These data support a model where copper is reduced on the enzyme by an externally provided electron and followed by oxygen binding and activation by ..
  54. doi Cu/Zn ratios are associated with nutritional status, oxidative stress, inflammation, and immune abnormalities in patients on peritoneal dialysis
    Chih Hung Guo
    Institute of Biomedical Nutrition, Hung Kuang University, Taichung 433, Taiwan, ROC
    Clin Biochem 44:275-80. 2011
    We evaluated the relationship of the plasma copper/zinc (Cu/Zn) ratio with nutritional status, inflammation, oxidative stress, and immune function in peritoneal dialysis patients.
  55. ncbi Transcriptional response of Escherichia coli to external copper
    Kaneyoshi Yamamoto
    Department of Agricultural Chemistry, Kinki University, Nakamachi 3327 204, Nara 631 8505, Japan
    Mol Microbiol 56:215-27. 2005
    Transcriptional response of Escherichia coli upon exposure to external copper was studied using DNA microarray and in vivo and in vitro transcription assays...
  56. pmc Mammalian copper-transporting P-type ATPases, ATP7A and ATP7B: emerging roles
    Sharon La Fontaine
    Centre for Cellular and Molecular Biology, School of Life and Environmental Sciences, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia
    Int J Biochem Cell Biol 42:206-9. 2010
    b>Copper (Cu) has a role in a diverse and increasing number of pathways, physiological and disease processes...
  57. ncbi Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis
    Kevin J Barnham
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    J Biol Chem 278:17401-7. 2003
    A major source of free radical production in the brain derives from copper. To prevent metal-mediated oxidative stress, cells have evolved complex metal transport systems...
  58. ncbi Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron
    Christa J Maynard
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    J Biol Chem 277:44670-6. 2002
    ..b>Copper and iron levels both show marked increases with age and may adversely interact with the amyloid-beta (Abeta) ..
  59. pmc Chemistry and biology of the copper chelator methanobactin
    Grace E Kenney
    Departments of Molecular Biosciences and of Chemistry, Northwestern University, Evanston, Illinois 60208, United States
    ACS Chem Biol 7:260-8. 2012
    Methanotrophic bacteria, organisms that oxidize methane, produce a small copper chelating molecule called methanobactin (Mb). Mb binds Cu(I) with high affinity and is hypothesized to mediate copper acquisition from the environment...
  60. ncbi Acquisition of resistance to cisplatin is accompanied by changes in the cellular pharmacology of copper
    Kuniyuki Katano
    Department of Medicine and the Cancer Center, University of California, San Diego, La Jolla, California 92093 0058, USA
    Cancer Res 62:6559-65. 2002
    ..The DDP-resistant cells had 22-56% lower basal levels of copper, and the copper levels were only 27-46% of those observed in the sensitive parental lines after a 24-h exposure to ..
  61. pmc The CopRS two-component system is responsible for resistance to copper in the cyanobacterium Synechocystis sp. PCC 6803
    Joaquín Giner-Lamia
    Instituto de Bioquimica Vegetal y Fotosintesis, Universidad de Sevilla, Consejo Superior de Investigaciones Cientificas, E 41092 Seville, Spain
    Plant Physiol 159:1806-18. 2012
    Photosynthetic organisms need copper for cytochrome oxidase and for plastocyanin in the fundamental processes of respiration and photosynthesis...
  62. pmc A new structural paradigm in copper resistance in Streptococcus pneumoniae
    Yue Fu
    Department of Chemistry, Indiana University, Bloomington, Indiana, USA
    Nat Chem Biol 9:177-83. 2013
    b>Copper resistance has emerged as an important virulence determinant of microbial pathogens...
  63. ncbi Old iron, young copper: from Mars to Venus
    R R Crichton
    Unite de Biochimie, Universite Catholique de Louvain, Belgium
    Biometals 14:99-112. 2001
    Iron and copper are metals which play an important role in the living world...
  64. ncbi Copper toxicity, oxidative stress, and antioxidant nutrients
    Lisa M Gaetke
    Department of Nutrition and Food Science, University of Kentucky, 218 Funkhouser Building, Lexington, KY 40506 0054, USA
    Toxicology 189:147-63. 2003
    b>Copper (Cu) is an integral part of many important enzymes involved in a number of vital biological processes...
  65. doi Molecular responses of human lung epithelial cells to the toxicity of copper oxide nanoparticles inferred from whole genome expression analysis
    Nobutaka Hanagata
    Nanotechnology Innovation Station, National Institute for Materials Science, 1 2 1 Sengen, Tsukuba, Ibaraki 305 0047, Japan
    ACS Nano 5:9326-38. 2011
    This study proposes a molecular mechanism for lung epithelial A549 cell response to copper oxide nanoparticles (CuO-NPs) related to Cu ions released from CuO-NPs...
  66. ncbi Copper transporting P-type ATPases and human disease
    Diane W Cox
    Department of Medical Genetics, University of Alberta, Edmonton, Alberta, Canada
    J Bioenerg Biomembr 34:333-8. 2002
    b>Copper transporting P-type ATPases, designated ATP7A and ATP7B, play an essential role in mammalian copper balance. Impaired intestinal transport of copper, resulting from mutations in the ATP7A gene, lead to Menkes disease in humans...
  67. ncbi Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase
    T D Rae
    Department of Chemistry and Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA
    Science 284:805-8. 1999
    The copper chaperone for the superoxide dismutase (CCS) gene is necessary for expression of an active, copper-bound form of superoxide dismutase (SOD1) in vivo in spite of the high affinity of SOD1 for copper (dissociation constant = 6 fM)..
  68. pmc Systems biology approach in Chlamydomonas reveals connections between copper nutrition and multiple metabolic steps
    Madeli Castruita
    Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA
    Plant Cell 23:1273-92. 2011
    In this work, we query the Chlamydomonas reinhardtii copper regulon at a whole-genome level...
  69. ncbi Copper homeostasis in Enterococcus hirae
    Marc Solioz
    Department of Clinical Pharmacology, University of Berne, Murtenstrasse 35, 3010 Bern, Switzerland
    FEMS Microbiol Rev 27:183-95. 2003
    b>Copper is an essential component of life because of its convenient redox potential of 200-800 mV when bound to protein...
  70. ncbi Direct electron transfer between copper-containing proteins and electrodes
    Sergey Shleev
    Department of Analytical Chemistry, Lund University, P O Box 124, SE 221 00 Lund, Sweden
    Biosens Bioelectron 20:2517-54. 2005
    The electrochemistry of some copper-containing proteins and enzymes, viz...
  71. doi Hydrogen sulfide promotes wheat seed germination and alleviates oxidative damage against copper stress
    Hua Zhang
    School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei 230009, China
    J Integr Plant Biol 50:1518-29. 2008
    With the enhancement of copper (Cu) stress, the germination percentage of wheat seeds decreased gradually...
  72. ncbi The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene
    P C Bull
    Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    Nat Genet 5:327-37. 1993
    Wilson disease (WD) is an autosomal recessive disorder of copper transport, resulting in copper accumulation and toxicity to the liver and brain. The gene (WD) has been mapped to chromosome 13 q14.3...
  73. ncbi RESPONSIVE-TO-ANTAGONIST1, a Menkes/Wilson disease-related copper transporter, is required for ethylene signaling in Arabidopsis
    T Hirayama
    Plant Science Institute, Department of Biology, University of Pennsylvania, Philadelphia 19104, USA
    Cell 97:383-93. 1999
    ..RAN1 was cloned and found to encode a protein with similarity to copper-transporting P-type ATPases, including the human Menkes/Wilson proteins and yeast Ccc2p...
  74. ncbi Decreased hephaestin activity in the intestine of copper-deficient mice causes systemic iron deficiency
    Huijun Chen
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720 3104, USA
    J Nutr 136:1236-41. 2006
    b>Copper and iron metabolism intersect in mammals...
  75. ncbi Regulation of expression of methane monooxygenases by copper ions
    J C Murrell
    Dept of Biological Sciences, University of Warwick, Coventry, UK
    Trends Microbiol 8:221-5. 2000
    ..A unique metabolic switch, mediated by copper ions, regulates the expression of these enzymes...
  76. doi Role of kinetic factors in chemical vapor deposition synthesis of uniform large area graphene using copper catalyst
    Sreekar Bhaviripudi
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nano Lett 10:4128-33. 2010
  77. doi Characterisation of copper oxide nanoparticles for antimicrobial applications
    Guogang Ren
    School of Aerospace, Automotive Design and Engineering, University of Hertfordshire, Hatfield AL109AB, UK
    Int J Antimicrob Agents 33:587-90. 2009
    b>Copper oxide (CuO) nanoparticles were characterised and investigated with respect to potential antimicrobial applications...
  78. doi Copper and ceruloplasmin abnormalities in Alzheimer's disease
    George J Brewer
    Department of Human Genetics, University of Michigan, Ann Arbor, 48103, USA
    Am J Alzheimers Dis Other Demen 25:490-7. 2010
    The idea that copper may play a role in the pathogenesis of Alzheimer's disease is gaining momentum...
  79. pmc Copper and manganese induce yeast apoptosis via different pathways
    Qiuli Liang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Mol Biol Cell 18:4741-9. 2007
    ..Here, for the first time we studied two essential nutritional elements, copper and manganese, for their apoptotic effects in yeast Saccharomyces cerevisiae...
  80. doi Genotoxic potential of copper oxide nanoparticles in human lung epithelial cells
    Maqusood Ahamed
    King Abdullah Institute for Nanotechnology, King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia
    Biochem Biophys Res Commun 396:578-83. 2010
    b>Copper oxide nanoparticles (CuO NPs) are increasingly used in various applications. Recent studies suggest that oxidative stress may be the cause of the cytotoxicity of CuO NPs in mammalian cells...
  81. doi Methanotrophs and copper
    Jeremy D Semrau
    Department of Civil and Environmental Engineering, The University of Michigan, Ann Arbor, MI, USA
    FEMS Microbiol Rev 34:496-531. 2010
    ..It has been well-known for over 30 years that copper (Cu) plays a key role in the physiology and activity of methanotrophs, but it is only recently that we have begun ..
  82. doi Elevated copper and oxidative stress in cancer cells as a target for cancer treatment
    Anshul Gupte
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Cancer Treat Rev 35:32-46. 2009
    ..In this review we discuss the targeting of the elevated copper (both in serum and tumor) and oxidative stress levels in cancer with the aid of a copper chelator d-penicillamine (..
  83. doi Copper in the brain and Alzheimer's disease
    Ya Hui Hung
    The Mental Health Research Institute, Parkville, Vic, Australia
    J Biol Inorg Chem 15:61-76. 2010
    ..The brain is particularly vulnerable to oxidative damage induced by unregulated redox-active metals such as copper and iron, and the brains of AD patients display evidence of metal dyshomeostasis and increased oxidative stress...
  84. ncbi The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene
    R E Tanzi
    Neurology Department, Harvard Medical School, Boston, Massachusetts 02114
    Nat Genet 5:344-50. 1993
    Wilson disease (WD) is an autosomal recessive disorder characterized by the toxic accumulation of copper in a number of organs, particularly the liver and brain...
  85. ncbi The copper-iron chronicles: the story of an intimate relationship
    Paul L Fox
    Department of Cell Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Biometals 16:9-40. 2003
    During the last decade there has been a surge of interest and activity in exploring the metabolic links between copper and iron. This review describes more than a century and a half of effort that has led to our current understanding...
  86. doi The mitochondrial permeability transition, and oxidative and nitrosative stress in the mechanism of copper toxicity in cultured neurons and astrocytes
    Pichili V B Reddy
    Department of Pathology, University of Miami School of Medicine, Miami, FL 33101, USA
    Lab Invest 88:816-30. 2008
    b>Copper is an essential element and an integral component of various enzymes. However, excess copper is neurotoxic and has been implicated in the pathogenesis of Wilson's disease, Alzheimer's disease, prion conditions, and other disorders...
  87. doi CopR of Sulfolobus solfataricus represents a novel class of archaeal-specific copper-responsive activators of transcription
    Aramis Villafane
    Department of Biochemistry and Microbiology, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA
    Microbiology 157:2808-17. 2011
    In trace amounts, copper is essential for the function of key enzymes in prokaryotes and eukaryotes...
  88. doi Therapeutic potential of copper chelation with triethylenetetramine in managing diabetes mellitus and Alzheimer's disease
    Garth J S Cooper
    Centre for Advanced Discovery and Experimental Therapeutics, NIHR Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, UK
    Drugs 71:1281-320. 2011
    ..has been generated by my group's research programme, which has identified for the first time a previously unknown copper-overload state that is central to the pathogenesis of diabetic organ damage...
  89. doi Size-dependent toxicity of metal oxide particles--a comparison between nano- and micrometer size
    Hanna L Karlsson
    Unit for Analytical Toxicology, Department of Biosciences and Nutrition, Novum, Karolinska Insitutet, SE 141 57 Huddinge, Stockholm, Sweden
    Toxicol Lett 188:112-8. 2009
    ..In conclusion, nanoparticles are not always more toxic than micrometer particles, but the high toxicity of CuO nanoparticles shows that the nanolevel gives rise to specific concern...
  90. pmc Copper-free click chemistry in living animals
    Pamela V Chang
    Department of Chemistry, University of California, Berkeley, CA 94720 1460, USA
    Proc Natl Acad Sci U S A 107:1821-6. 2010
    ..These studies establish Cu-free click chemistry as a bioorthogonal reaction that can be executed in the physiologically relevant context of a mouse...
  91. doi Copper is toxic to PrP-ablated mice and exacerbates disease in a mouse model of E200K genetic prion disease
    Tamar Canello
    Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, 91120 Jerusalem, Israel
    Neurobiol Dis 45:1010-7. 2012
    ..mice and TgMHu2ME199K, a transgenic mouse line mimicking E200KCJD, were significantly more sensitive to copper toxicity than wt fibroblasts...
  92. doi Conservation and diversity of microRNA-associated copper-regulatory networks in Populus trichocarpa
    Shanfa Lu
    Medicinal Plant Cultivation Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    J Integr Plant Biol 53:879-91. 2011
    Plants develop important regulatory networks to adapt to the frequently-changing availability of copper (Cu). However, little is known about miRNA-associated Cu-regulatory networks in plant species other than Arabidopsis...
  93. doi Toxicity of nanoparticles of CuO, ZnO and TiO2 to microalgae Pseudokirchneriella subcapitata
    Villem Aruoja
    Laboratory of Molecular Genetics, National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, Tallinn 12618, Estonia
    Sci Total Environ 407:1461-8. 2009
    ..At 72 h EC50 values of nano CuO and CuO, 25% of copper from nano CuO was bioavailable and only 0.18% of copper from bulk CuO...
  94. pmc A novel copper-responsive regulon in Mycobacterium tuberculosis
    Richard A Festa
    New York University School of Medicine, Department of Microbiology, 550 First Avenue MSB 236, New York, NY 10016, USA
    Mol Microbiol 79:133-48. 2011
    In this work we describe the identification of a copper-inducible regulon in Mycobacterium tuberculosis (Mtb). Among the regulated genes was Rv0190/MT0200, a paralogue of the copper metalloregulatory repressor CsoR...
  95. pmc Missense mutations in the copper transporter gene ATP7A cause X-linked distal hereditary motor neuropathy
    Marina L Kennerson
    Northcott Neuroscience Laboratory, ANZAC Research Institute, University of Sydney, Concord, Australia
    Am J Hum Genet 86:343-52. 2010
    ..1-q21 in two large unrelated families. The region of genetic linkage included ATP7A, which encodes a copper-transporting P-type ATPase mutated in patients with Menkes disease, a severe infantile-onset neurodegenerative ..
  96. ncbi Copper and iron disorders of the brain
    Erik Madsen
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63130, USA
    Annu Rev Neurosci 30:317-37. 2007
    b>Copper and iron are transition elements essential for life. These metals are required to maintain the brain's biochemistry such that deficiency or excess of either copper or iron results in central nervous system disease...
  97. ncbi Proteomic characterization of copper stress response in Cannabis sativa roots
    Elisa Bona
    Department of Environmental and Life Sciences, University of Piemonte Orientale A Avogadro, Alessandria, Italy
    Proteomics 7:1121-30. 2007
    ..b>Copper is an essential micronutrient for all living organisms, it participates as an important redox component in ..
  98. ncbi Copper efflux from murine microvascular cells requires expression of the menkes disease Cu-ATPase
    Y Qian
    Departments of Biochemistry and Biophysics, Texas A and M University, College Station, TX 77843, USA
    J Nutr 128:1276-82. 1998
    ..This study provides strong evidence that a Cu-ATPase in the BBB controls the penetration of Cu into the brain and that lesions to the Cu-ATPase in CVE cells are a primary cause of low brain Cu levels in Menkes disease...
  99. pmc Copper transport to the brain by the blood-brain barrier and blood-CSF barrier
    Byung Sun Choi
    School of Health Sciences, Purdue University, 550 Stadium Mall Drive, West Lafayette, IN 47907 2051, USA
    Brain Res 1248:14-21. 2009
    The mechanism of copper (Cu) transport into the brain is unclear...
  100. doi Level of trace elements (copper, zinc, magnesium and selenium) and toxic elements (lead and mercury) in the hair and nail of children with autism
    Malarveni Damodaran Lakshmi Priya
    Department of Biochemistry, Bharathi Women s College, Chennai, 600 108 Tamil Nadu, India
    Biol Trace Elem Res 142:148-58. 2011
    ..Therefore, the purpose of the present study was to assess the levels of trace elements like copper (Cu), zinc (Zn), magnesium (Mg), and selenium (Se) and toxic elements like mercury (Hg), and lead (Pb) in the hair ..
  101. doi Toxicity of nanoparticles of ZnO, CuO and TiO2 to yeast Saccharomyces cerevisiae
    Kaja Kasemets
    Laboratory of Molecular Genetics, National Institute of Chemical Physics and Biophysics, 12618 Tallinn, Estonia
    Toxicol In Vitro 23:1116-22. 2009
    ..The increase in toxicity of both CuO formulations at 24th hour of growth was due to the increased dissolution of copper ions from CuO over time...

Research Grants69

  1. Lung Lysyl Oxidase Regulation by Metal Ion Homeostasis
    Wande Li; Fiscal Year: 2013
    PROJECT ABSTRACT. Lysyl oxidase (LO), a copper-(Cu) dependent enzyme, oxidizes peptidyl lysine residues in substrates, e.g...
  2. Investigating Mechanism of Intracellular Rotational Transport with Optical T
    Jeffrey N Anker; Fiscal Year: 2012
    ..Specifically, we measure toxicity of copper oxide and titanium dioxide which are widely used and have important ramifications for human health.
  3. Analyzer for Monitoring Personal Environmental Exposure to Fluids and Materials
    MATTHEW CUSACK; Fiscal Year: 2010
    ..Abnormal levels of bio-essential metals (iron, copper, and zinc) as well as toxic trace elements (mercury, lead, cadmium, and arsenic) are known to be associated with ..
  4. Brain Delivery of Nanoformulated Superoxide Dismutase
    Erin G Rosenbaugh; Fiscal Year: 2013
    ..Previous studies have shown that adenoviral-mediated overexpression of the O2O- scavenging enzyme copper/zinc superoxide dismutase (CuZnSOD) attenuates central AngII-dependent cardiovascular dysfunction...
  5. Expanded Testing Methods for Elements and Metals in Animal Diagnostic Specimens
    Timothy Baszler; Fiscal Year: 2013
    ..2011-2012 revealed over 50 contamination events nationwide attributed to 8 trace elements and heavy metals such as copper, sulfur, lead, arsenic, zinc, selenium and 9 phosphorus...
  6. Electron Transfer in Iron and Copper Proteins
    Jay R Winkler; Fiscal Year: 2013
    ..Efforts will focus on oxidative generation of Compounds I and II in cytochromes P450 (Aim 3) and a bacterial enzyme that exhibits NOS-like reactivity (Aim 4). ..
  7. Excessive Copper Levels Disrupt Hepatic Nuclear Receptor Function
    Clavia Ruth Wooton-Kee; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Our long-term objective is to determine the effect of copper on the DNA-binding activity and structure of hepatic nuclear receptors and expression of hepatic nuclear receptor target genes in a mouse ..
  8. Biosynthetic Protein Models of Heme-copper Oxidases and Nitric Oxide Reductases
    Yi Lu; Fiscal Year: 2013
    ..e., why a protein is proficient at O-O bond cleavage when using a heme-copper center as in heme-copper oxidases (HCO), and is effective at N-N bond formation when using a heme-non-heme iron ..
  9. Tyrosinase Model Complexes using Imidazole Ligands
    JOHN BRANNON GARY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Many proteins in nature contain copper in their active sites, and these sites are typically involved in redox catalysis performing a wide array biological functions such as electron carrier proteins (..
  10. Mitochondrial Metabolism and ROS Regulate Lung Cancer
    Navdeep S Chandel; Fiscal Year: 2013 the cytosol is hydrogen peroxide (H2O2), which is generated by its conversion from superoxide (O2-) by copper-zinc superoxide dismutase (SOD1) in the cytosol...
  11. Copper's Role in Brain LRP-mediated Abeta Efflux and Aging
    Rashid Deane; Fiscal Year: 2010
    ..b>Copper (Cu), the focus of this research proposal, is associated with amyloid plaques in AD brains...
  12. DNA Repair of Endogenous Lesions in Carcinogenesis
    Rabindra Roy; Fiscal Year: 2010
    ..Like Wilson's disease (WD) patients, LEG rats accumulate excess copper in the liver and consequently the organ experiences severe inflammation and oxidative stress...
  13. PET Imaging of Thrombus
    PETER D CARAVAN; Fiscal Year: 2013
    ..In Aim 1 we focus on synthesizing a series of fluorine-18 and copper-64 labeled peptides to optimize the imaging properties of thrombus-targeted PET probe...
  14. Transport ATPases: From Molecules to Maladies
    Rajini Rao; Fiscal Year: 2010
    ..Still others control the movement of trace metals, like copper into metalloenzymes...
  15. Role of p62 in Protein Aggregation and Neurodegeneration in ALS
    Haining Zhu; Fiscal Year: 2009
    ..Protein aggregates containing mutant copper-zinc superoxide dismutase (SOD1) are a hallmark of familial amyotrophic lateral sclerosis (ALS, Lou Gehrig's ..
  16. Peroxynitrite, nitrotyrosine and HSP90 in neuronal death
    ALVARO G ESTEVEZ; Fiscal Year: 2013
    ..Furthermore, the copper in zinc-deficient SOD can act as a non-specific one-electron oxidase, robbing electrons from antioxidants like ..
    Julian H Lombard; Fiscal Year: 2012 due to an increase in vascular oxidative stress resulting from down regulation of antioxidant enzymes such as copper/zinc superoxide dismutase (Cu/Zn SOD), and possibly upregulation of pro- oxidant enzymes...
  18. Role of Polyamine Oxidase in Apoptosis Studies with RNA Interference
    GLENN KUEHN; Fiscal Year: 2009
    ..3) Methodologies, plant seed stocks, and plasmid vectors will be developed in order to exploit a synthetic copper(ll) ion-dependent genetic promoter system, produced by our laboratory, for controlling the synthesis of trans ..
  19. Structure and Specificity in Metal Ion Homeostasis
    Amy C Rosenzweig; Fiscal Year: 2013
    ..Aberrant handling of metal ions such as copper, zinc, iron, and manganese is linked to numerous human diseases...
  20. Copper transport protein and inflammatory angiogenesis
    Masuko Ushio-Fukai; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The overall aim of this grant is to elucidate the novel linkage between copper transport protein "Antioxidant1 (Atox1)" and "NADPH oxidase" involved in inflammatory angiogenesis...
  21. Environmental and genetic regulation of copy number variation (CNV)
    THOMAS PETES; Fiscal Year: 2010
    ..that contains two yeast genes SFA1 and CUP1 that confer gene dosage-dependent tolerance to formaldehyde and copper, respectively...
  22. Molecular Mechanisms of Intestinal Metal Ion Transport During Iron Deficiency
    James F Collins; Fiscal Year: 2013
    ..We made the novel observation that copper-related processes are activated by iron deprivation of rodents...
  23. Cu,Zn-SOD, MMP-9, and Asbestosis
    A Brent Carter; Fiscal Year: 2013
    ..We will also determine the role of copper chaperone for Cu,Zn-SOD (CCS) in regulating translocation and activation...
  24. Soft Metal, Disulfide, and Cysteine Stresses in Escherichia coli
    James A Imlay; Fiscal Year: 2013
    ..In recent published work we demonstrated that copper poisons E. coli primarily by inactivating Fe/S-dependent dehydratases...
  25. Cisplatin Resistance mediated by copper export pathways
    Stephen B Howell; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The copper (Cu) exporter ATP7B is over-expressed in many tumors with acquired resistance to Cu, cisplatin (DDP) and carboplatin...
  26. Transgenic Study of ALS-Linked CCS Mutations
    Han Xiang Deng; Fiscal Year: 2011
    ..Because the copper chaperone for SOD1 (CCS) shares high homology with SOD1 and overexpression of wild-type CCS (wtCCS) significantly ..
  27. Development of A Novel Anti-Hyperglycemic Agent
    Zhaoping Li; Fiscal Year: 2012
    ..signs, physical exams, blood hematology, chemistry, liver, renal, thyroid function tests, urine analysis and zinc, copper levels...
  28. Targeting copper homeostasis in the fungal pathogen, Cryptococcus neoformans
    RICHARD FESTA; Fiscal Year: 2013
    ..b>Copper (Cu) serves as an essential co-factor for a wide variety of enzymes in fungi and humans, but excess Cu is toxic ..
    ELIZABETH ANNE EIPPER; Fiscal Year: 2013
    ..14.17.3), the first enzyme of the bifunctional PAM protein, requires copper and ascorbate;in man, both must be acquired from the diet...
  30. Selenium, other risk factors and cognitive decline in rural elderly Chinese
    Sujuan Gao; Fiscal Year: 2013
    ..Higher plasma cadmium and copper levels, on the other hand, were associated with lower cognitive scores...
  31. Function of Laccases in Anopheles gambiae
    Michael R Kanost; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Project summary: Laccases are copper-containing oxidases with broad substrate specificity...
  32. Dissecting the Regulation of Zinc-Homeostasis
    Davin Malasarn; Fiscal Year: 2010
    ..key zinc-responsive targets and assess the role of Crr1, a transcription factor known to regulate both zinc- and copper-responsive genes, in zinc homeostasis and 3) to use a classical genetic approach to identify components of ..
  33. Toxic Metal Complexation by de Novo Designed Peptides
    Vincent L Pecoraro; Fiscal Year: 2013
    ..We are also relating this work to studies on proteins used to recognize or detoxify heavy metals in bacteria, fungi and humans (e.g., assessing how HgII interacts with the human copper chaperone HAH1).
  34. Copper Uptake from Plasma Ceruloplasmin
    Maria C Linder; Fiscal Year: 2012
    ..cell surface, detection of 64Cu from Cp in the cytosol, monitoring of Cu entry by use of intracellular fluorescent copper probes, and rescue of SOD1 or cytochrome c oxidase activity (or down-regulation of CCS Cu chaperone protein levels)..
  35. Spectroscopic Studies of Active Sites in Copper Proteins
    Edward I Solomon; Fiscal Year: 2011
    ..of oxy-tyrosinase and determination of differences in substrate interaction with the similar coupled binuclear copper sites in hemocyanin, tyrosinase, mutants of tyrosinase associated with oculocutaneous albinism, and catechol ..
  36. Fluorescent Copper Probes for Intracellular Imaging
    Christoph J Fahrni; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Copper is an essential trace element, which is critical to human health...
    Kenneth D Karlin; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): The goal of the proposed research is to further develop fundamental aspects of copper coordination chemistry relevant to its essential role in the biochemical processing of dioxygen (O2) and nitrogen ..
  38. Molecular Mechanisms of SOD1-linked ALS (P01)
    Joan Selverstone Valentine; Fiscal Year: 2013
    ..a subset of cases caused by genetic mutations are familial, of which those caused by mutations in the protein copper-zinc superoxide dismutase (SODl) represent the most extensively studied model of ALS...
  39. Safety and Acceptability of Two IUDs among Cape Town HIV-positive Women: A RCT
    CATHERINE SUZANNE TODD; Fiscal Year: 2013
    ..ART-na[unreadable]ve (CD4>500) women enrolled in a 1:1 ratio to Intervention (LNG IUD) and Control (copper T380 IUD) arms and followed at 3, 6, 9, 12, 18, and 24 months to determine comparative safety and acceptability of ..
  40. Mechanisms of Metal Ion Regulation in Human Cells
    Svetlana Lutsenko; Fiscal Year: 2013
    The overall goal of this program is to generate a comprehensive mechanistic picture of human copper homeostasis in normal and diseased cells and tissues...
    Buck E Rogers; Fiscal Year: 2012
    ..BN (BN(7-14)) conjugated to 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and radiolabeled with copper-64 (64Cu)...
  42. Removing copper for pennies: an affordable strategy for Alzheimer's
    Joseph F Quinn; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Objectives: The overall objective is to evaluate the feasibility of copper chelating strategies for the prevention and treatment of Alzheimer's disease...
  43. Endovascular Magnetic Catheter for Interventional MRI
    STEVEN WILLIAM HETTS; Fiscal Year: 2013
    ..If a tiny magnetic moment is created on the tip of the catheter by application of a small electrical current to copper coils on the catheter tip, then the tip of the catheter will move to align with the bore of the MRI scanner (the ..
  44. The Role of Toxic Ion Channels in ALS Pathogenesis
    Michael J Allen; Fiscal Year: 2013
    ..In ALS, the misfolded structural state of copper-zinc super-oxide dismutase (SOD1) imparts a function to this normally beneficial protein that is essential to ..
  45. Cell Death/Survival After Global Cerebral Ischemia
    Pak H Chan; Fiscal Year: 2013
    ..An increase in the cytosolic antioxidant copper/zinc-superoxide dismutase in transgenic mice and transgenic rats significantly ameliorates molecular and cellular ..
  46. Mechanistic insights into copper metabolism
    Jaekwon Lee; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Copper is a vital metal ion for sustaining life...
  47. Nutritional Copper Signaling and Homeostasis
    Sabeeha Merchant; Fiscal Year: 2013
    ..These reactions are central to aerobic life. Our long term goal is to understand the metabolism of copper, especially when it is a limiting nutrient or in a situation of metabolic defect...
  48. Cholesterol and copper affect learning and memory
    Bernard G Schreurs; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cholesterol and copper are crucial to nutrition and normal brain function but recent evidence also implicates both in Alzheimer's disease...
  49. Studies of metal-dependent intercellular adhesion in Staphylococcal biofilms
    Andrew B Herr; Fiscal Year: 2013
    ..In the presence of zinc or copper, these constructs form fibrous aggregates with amyloid-like characteristics...
  50. Mechanism of the Transcriptional Response to Transition Metals
    MICHAEL THOMAS MARR; Fiscal Year: 2013
    Essential divalent transition metals such as zinc, copper, and iron play important structural and catalytic roles in over 300 proteins. However, these and other transition metals also pose a potential threat to an organism...
  51. Cues for cell-mediated regeneration of elastin matrix in aortic aneurysms
    Anand Ramamurthi; Fiscal Year: 2012
    ..Aim 2 will evaluate dose-specific effects of copper ion delivery from copper nanoparticles (CuNP), concurrent with optimized LOX cues, to LOX activity and to elastin ..
  52. Nanoparticle Brain Delivery of Iron Chelators for AD
    Gang Liu; Fiscal Year: 2010
    ..b>Copper chelators will also be used for conjugation and testing to obtain insights into the roles of different metals in ..
    Robert B Gennis; Fiscal Year: 2013 water and conserve the free energy liberated by this reaction by generating a proton motive force- (1) The heme-copper oxygen reductases;(2) the bd-type oxygen reductases...
  54. Mechanistic insights into cellular metal detoxification
    Jaekwon Lee; Fiscal Year: 2013
    ..Mutations in copper transporting P-type ATPases lead to lethal genetic diseases in humans, which highlights the essential role for P-..
    Monica Shokeen; Fiscal Year: 2013
    ..In this proposal, we will develop a high-affinity and high-specific activity, copper-64 labeled VLA-4 targeted PET radiopharmaceutical (64Cu-LLP2A) to assess disease progression and response to ..
  56. Quantification of Immune Cells in Women Using Contraception
    SHARON LYNELLE ACHILLES; Fiscal Year: 2013
    ..medroxyprogesterone acetate (Depo-Provera(R)), (3) a levonorgestrel intrauterine device (Mirena(R)), or (4) a copper intrauterine device (ParaGard(R)), plus 25 women using condoms alone...
  57. Role of Prion Protein in Manganese Neurotoxicity
    ..that prion proteins are metal binding proteins that can efficiently bind to certain divalent cations including copper and manganese at the octapeptide repeat regions of the protein...
  58. Biological significance of Mallory-Denk bodies in mouse and human liver diseases
    Amika Singla; Fiscal Year: 2011
    ..and nonalcoholic), but can also be found in other liver disorders including hepatocellular carcinoma and copper metabolism disorders...
  59. Mechanism of Peroxiredoxin 3 in a Model of Pesticide-Mediated Neurodegeneration
    JAMES R ROEDE; Fiscal Year: 2012
    ..To examine MB-mediated effects, aldehyde dehydrogenase activity and intracellular copper accumulation will be measured...
    THOMAS V O'HALLORAN; Fiscal Year: 2013
    ..are emerging from the study of inorganic physiology, including the idea that intracellular metals such as zinc, copper and iron are not 'trace elements'from a cellular point of view, but are routinely maintained in most ..
  61. The novel family of superoxide dismutase enzymes in Candida albicans
    Valeria C Culotta; Fiscal Year: 2013
    ..One set of virulence factors for C. albicans includes a family of copper containing superoxide dismutase (SOD) enzymes that scavenge toxic superoxide free radicals...
    Carolyn J Anderson; Fiscal Year: 2012
    ..of 64Cu (and 67Cu) radiopharmaceuticals, these findings may be relevant to mechanisms of cell killing with copper radionuclides. We are currently addressing two hypotheses relevant to imaging and therapy with 64Cu...
    KENNETH KARLIN; Fiscal Year: 1993
    ..The focus of the proposed research involves studies of the chemistry of copper ion catalyzed processes, known to effect the reduction of nitrite ion to nitrous oxide (possibly through nitric ..
    Andrew Gordon; Fiscal Year: 1991
    ..goals of the proposed research are to elucidate the role of bacteria in modifying metal ion (particularly copper) speciation in aquatic environments...
    Marius Brouwer; Fiscal Year: 1992
    DESCRIPTION (Adapted from the applicant's abstract): Copper is an essential but toxic trace metal that has been implicated in oxidative damage to DNA, proteins, and membranes...
    Jay Gorell; Fiscal Year: 2001
    ..The focus of that work was the assessment of occupational exposure to six metals (iron, manganese, copper, lead, mercury, and zinc) and the risk of PD...
  67. Intestinal Iron Transport in Iron Deficiency/Anemia
    James Collins; Fiscal Year: 2005
    ..These changes include 4-12-fold upregulation of the basolateral membrane-specific copper ATPase (Atp7a), and 2-5-fold increases in a membrane bound form of ceruloplasmin, a multi-copper ferroxidase, ..
    Kenneth Allen; Fiscal Year: 1991
    The central hypothesis to be tested is that dietary copper, through changes in CuSOD activity, will influence tissue PG production by altering the concentration of lipid hydroperoxide activators of PGH synthetase...
  69. Iron and copper transporter trafficking in healthy and diseased melanocytes
    Michael Marks; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Copper and iron are cofactors for many cellular enzymes and transporters, but are also toxic redox-reactive transition metals...