cadmium

Summary

Summary: An element with atomic symbol Cd, atomic number 48, and atomic weight 114. It is a metal and ingestion will lead to CADMIUM POISONING.

Top Publications

  1. ncbi Current status of cadmium as an environmental health problem
    Lars Jarup
    Department of Epidemiology and Public Health, Imperial College London, London, UK
    Toxicol Appl Pharmacol 238:201-8. 2009
  2. ncbi Dietary cadmium exposure and risk of postmenopausal breast cancer: a population-based prospective cohort study
    Bettina Julin
    Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Cancer Res 72:1459-66. 2012
  3. pmc Reduction in cadmium exposure in the United States population, 1988-2008: the contribution of declining smoking rates
    Maria Tellez-Plaza
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room W7513D, Baltimore, MD 21205 USA
    Environ Health Perspect 120:204-9. 2012
  4. pmc Cadmium exposure and cancer mortality in the Third National Health and Nutrition Examination Survey cohort
    Scott V Adams
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Occup Environ Med 69:153-6. 2012
  5. pmc Genome-wide identification of Brassica napus microRNAs and their targets in response to cadmium
    Zhao Sheng Zhou
    Jiangsu Province Key Laboratory of Marine Biology, College of Resources and Environmental Science, Nanjing Agricultural University, Nanjing, China
    J Exp Bot 63:4597-613. 2012
  6. ncbi Hazards of heavy metal contamination
    Lars Jarup
    Department of Epidemiology and Public Health, Imperial College, London, UK
    Br Med Bull 68:167-82. 2003
  7. ncbi Role of oxidative stress in cadmium toxicity and carcinogenesis
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 238:209-14. 2009
  8. pmc Microarray-based analysis of cadmium-responsive microRNAs in rice (Oryza sativa)
    Yanfei Ding
    State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou 310029, China
    J Exp Bot 62:3563-73. 2011
  9. pmc Cadmium exposure and neurodevelopmental outcomes in U.S. children
    Timothy Ciesielski
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 120:758-63. 2012
  10. pmc Long-distance transport, vacuolar sequestration, tolerance, and transcriptional responses induced by cadmium and arsenic
    David G Mendoza-Cózatl
    Division of Biological Sciences, Cell and Developmental Biology Section, University of California, San Diego, La Jolla, CA 92093 0116, USA
    Curr Opin Plant Biol 14:554-62. 2011

Detail Information

Publications386 found, 100 shown here

  1. ncbi Current status of cadmium as an environmental health problem
    Lars Jarup
    Department of Epidemiology and Public Health, Imperial College London, London, UK
    Toxicol Appl Pharmacol 238:201-8. 2009
    b>Cadmium is a toxic metal occurring in the environment naturally and as a pollutant emanating from industrial and agricultural sources. Food is the main source of cadmium intake in the non-smoking population...
  2. ncbi Dietary cadmium exposure and risk of postmenopausal breast cancer: a population-based prospective cohort study
    Bettina Julin
    Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Cancer Res 72:1459-66. 2012
    The ubiquitous food contaminant cadmium has features of an estrogen mimetic that may promote the development of estrogen-dependent malignancies, such as breast cancer...
  3. pmc Reduction in cadmium exposure in the United States population, 1988-2008: the contribution of declining smoking rates
    Maria Tellez-Plaza
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room W7513D, Baltimore, MD 21205 USA
    Environ Health Perspect 120:204-9. 2012
    ..policies such as tobacco control, air pollution reduction, and hazardous waste remediation may have reduced cadmium exposure among U.S. adults...
  4. pmc Cadmium exposure and cancer mortality in the Third National Health and Nutrition Examination Survey cohort
    Scott V Adams
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Occup Environ Med 69:153-6. 2012
    ..National Health and Nutrition Examination Survey (NHANES III) cohort to investigate the relationship between cadmium exposure and cancer mortality, and the specific cancers associated with cadmium exposure, in the general ..
  5. pmc Genome-wide identification of Brassica napus microRNAs and their targets in response to cadmium
    Zhao Sheng Zhou
    Jiangsu Province Key Laboratory of Marine Biology, College of Resources and Environmental Science, Nanjing Agricultural University, Nanjing, China
    J Exp Bot 63:4597-613. 2012
    ..The toxic heavy metal cadmium (Cd) induces expression of several miRNAs in rapeseed (Brassica napus), but it is not known on a genome-wide ..
  6. ncbi Hazards of heavy metal contamination
    Lars Jarup
    Department of Epidemiology and Public Health, Imperial College, London, UK
    Br Med Bull 68:167-82. 2003
    The main threats to human health from heavy metals are associated with exposure to lead, cadmium, mercury and arsenic...
  7. ncbi Role of oxidative stress in cadmium toxicity and carcinogenesis
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 238:209-14. 2009
    b>Cadmium (Cd) is a toxic metal, targeting the lung, liver, kidney, and testes following acute intoxication, and causing nephrotoxicity, immunotoxicity, osteotoxicity and tumors after prolonged exposures...
  8. pmc Microarray-based analysis of cadmium-responsive microRNAs in rice (Oryza sativa)
    Yanfei Ding
    State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou 310029, China
    J Exp Bot 62:3563-73. 2011
    ..Plant miRNAs have been implicated in developmental processes and adaptations to environmental stresses. Cadmium (Cd) is a non-essential heavy metal that is highly toxic to plants...
  9. pmc Cadmium exposure and neurodevelopmental outcomes in U.S. children
    Timothy Ciesielski
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 120:758-63. 2012
    Low-level environmental cadmium exposure in children may be associated with adverse neurodevelopmental outcomes.
  10. pmc Long-distance transport, vacuolar sequestration, tolerance, and transcriptional responses induced by cadmium and arsenic
    David G Mendoza-Cózatl
    Division of Biological Sciences, Cell and Developmental Biology Section, University of California, San Diego, La Jolla, CA 92093 0116, USA
    Curr Opin Plant Biol 14:554-62. 2011
    Iron, zinc, copper and manganese are essential metals for cellular enzyme functions while cadmium, mercury and the metalloid arsenic lack any biological function...
  11. ncbi Plant science: the key to preventing slow cadmium poisoning
    Stephan Clemens
    Department of Plant Physiology, University of Bayreuth, 95440 Bayreuth, Germany
    Trends Plant Sci 18:92-9. 2013
    Practically all human populations are environmentally exposed to cadmium (Cd), mostly through plant-derived food...
  12. ncbi Gated access to the pore of a voltage-dependent K+ channel
    Y Liu
    Department of Neurobiology, Harvard Medical School and Massachusetts General Hospital, Boston 02114, USA
    Neuron 19:175-84. 1997
    ..The results suggest that these channels open and close by the movement of an intracellular gate, distinct from the selectivity filter, that regulates access to the pore...
  13. pmc Cadmium, environmental exposure, and health outcomes
    Soisungwan Satarug
    Department of Pathology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202, USA
    Environ Health Perspect 118:182-90. 2010
    We provide an update of the issues surrounding health risk assessment of exposure to cadmium in food.
  14. ncbi Transport pathways for cadmium in the intestine and kidney proximal tubule: focus on the interaction with essential metals
    David A Vesey
    Department of Nephrology, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Brisbane, Queensland 4102, Australia
    Toxicol Lett 198:13-9. 2010
    b>Cadmium (Cd) is a toxic metal with a propensity to accumulate in the proximal tubules cells (PTC) of the kidney where it can lead to tubular dysfunction and eventually renal failure...
  15. ncbi Roles of hydrogen sulfide and nitric oxide in the alleviation of cadmium-induced oxidative damage in alfalfa seedling roots
    Le Li
    College of Life Sciences, Cooperative Demonstration Laboratory of Centrifuge Technique of Nanjing Agricultural University and Beckman Coulter Ltd Co, Nanjing 210095, People s Republic of China
    Biometals 25:617-31. 2012
    ..In the present study, we evaluated the effects of H(2)S and NO on alfalfa (Medicago sativa L.) plants exposed to cadmium (Cd) stress...
  16. ncbi Cadmium: cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences (a review)
    G Bertin
    Institut Curie UMR 2027 CNRS Génotoxicologie et cycle cellulaire, LCR V28 du CEA, Centre Universitaire, 91405 Orsay Cedex, France
    Biochimie 88:1549-59. 2006
    b>Cadmium is an important toxic environmental heavy metal. Occupational and environmental pollution with cadmium results mainly from mining, metallurgy industry and manufactures of nickel-cadmium batteries, pigments and plastic stabilizers...
  17. ncbi Molecular mechanisms of metal hyperaccumulation in plants
    Nathalie Verbruggen
    Universite Libre de Bruxelles, B 1050 Brussels, Belgium
    New Phytol 181:759-76. 2009
    ..This review presents key aspects of our current understanding of plant metal – in particular cadmium (Cd),nickel (Ni) and zinc (Zn) – hyperaccumulation.
  18. ncbi Catch me if you can! Novel aspects of cadmium transport in mammalian cells
    Frank Thevenod
    Department of Physiology and Pathophysiology, University of Witten Herdecke, Stockumer Str 12, Witten, Germany
    Biometals 23:857-75. 2010
    b>Cadmium (Cd(2+)) is a nonessential divalent metal ion that causes toxicity in multiple organs in humans. In order for toxicity to occur Cd(2+) must first enter cells by utilizing transport pathways for essential metals...
  19. pmc Orthologs of the class A4 heat shock transcription factor HsfA4a confer cadmium tolerance in wheat and rice
    Donghwan Shim
    POSTECH UZH Global Research Laboratory, Division of Integrative Biology and Biotechnology, Pohang University of Science and Technology, Pohang, 790 784, Korea
    Plant Cell 21:4031-43. 2009
    b>Cadmium (Cd) is a widespread soil pollutant; thus, the underlying molecular controls of plant Cd tolerance are of substantial interest...
  20. ncbi Associations between proteins and heavy metals in urine at low environmental exposures: evidence of reverse causality
    Agnès Chaumont
    Louvain Center for Toxicology and Applied Pharmacology, Faculty of Medicine, Catholic University of Louvain, Brussels, Belgium
    Toxicol Lett 210:345-52. 2012
    ..a cross-sectional study performed on 736 adolescents, we assessed the associations between the concentrations of cadmium and lead in blood and urine and the urinary concentrations of albumin and of low-molecular-weight (LMW) proteins, ..
  21. ncbi Molecular and cellular mechanisms of cadmium carcinogenesis
    Michael Waisberg
    Department of Land Resource Science, University of Guelph, Guelph, Ont, Canada
    Toxicology 192:95-117. 2003
    b>Cadmium is a heavy metal, which is widely used in industry, affecting human health through occupational and environmental exposure...
  22. pmc Nramp5 is a major transporter responsible for manganese and cadmium uptake in rice
    Akimasa Sasaki
    Institute of Plant Science and Resources, Okayama University, Kurashiki, Japan
    Plant Cell 24:2155-67. 2012
    ..Taken together, Nramp5 is a major transporter of Mn and Cd and is responsible for the transport of Mn and Cd from the external solution to root cells...
  23. pmc Tubular and glomerular kidney effects in Swedish women with low environmental cadmium exposure
    Agneta Akesson
    Institute of Environmental Medicine, Division of Metals and Health, Karolinska Institutet, Stockholm, Sweden
    Environ Health Perspect 113:1627-31. 2005
    b>Cadmium is a well-known nephrotoxic agent in food and tobacco, but the exposure level that is critical for kidney effects in the general population is not defined...
  24. ncbi Cadmium carcinogenesis
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Triangle Park, NC 27706, USA
    Mutat Res 533:107-20. 2003
    b>Cadmium is a heavy metal of considerable environmental and occupational concern. Cadmium compounds are classified as human carcinogens by several regulatory agencies...
  25. ncbi Environmental exposure to cadmium and risk of cancer: a prospective population-based study
    Tim Nawrot
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Lancet Oncol 7:119-26. 2006
    b>Cadmium is a ubiquitous environmental pollutant, which accumulates in the human body such that 24-h urinary excretion is a biomarker of lifetime exposure...
  26. pmc Dietary cadmium exposure and prostate cancer incidence: a population-based prospective cohort study
    B Julin
    Unit of Nutritional Epidemiology, The Institute of Environmental Medicine, Karolinska Institutet, Box 210, 171 77 Stockholm, Sweden
    Br J Cancer 107:895-900. 2012
    Experimental data convincingly propose the toxic metal cadmium as a prostate carcinogen. Cadmium is widely dispersed into the environment and, consequently, food is contaminated.
  27. ncbi Cadmium-induced functional and ultrastructural alterations in roots of two transgenic cotton cultivars
    M K Daud
    Department of Agronomy, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310029, PR China
    J Hazard Mater 161:463-73. 2009
    The toxic effect of cadmium (Cd) at increasing concentrations was studied with special attention being given to the root morphological and ultrastructural changes in two transgenic cotton cultivars viz...
  28. ncbi Nrf2 activation prevents cadmium-induced acute liver injury
    Kai C Wu
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Toxicol Appl Pharmacol 263:14-20. 2012
    Oxidative stress plays an important role in cadmium-induced liver injury. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that up-regulates cytoprotective genes in response to oxidative stress...
  29. pmc Metabolic profiling detects early effects of environmental and lifestyle exposure to cadmium in a human population
    James K Ellis
    Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, UK
    BMC Med 10:61. 2012
    ..We investigated changes in metabolism in volunteers living near a point source of environmental pollution: a closed zinc smelter with associated elevated levels of environmental cadmium.
  30. pmc Confounders in the assessment of the renal effects associated with low-level urinary cadmium: an analysis in industrial workers
    Nahida Haddam
    Laboratory of Medical Toxicology, Faculty of Medicine, University Abou Bekr Belkaid, Tlemcen, Algeria
    Environ Health 10:37. 2011
    Associations of proteinuria with low-level urinary cadmium (Cd) are currently interpreted as the sign of renal dysfunction induced by Cd...
  31. pmc Cadmium levels in urine and mortality among U.S. adults
    Andy Menke
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Environ Health Perspect 117:190-6. 2009
    b>Cadmium exposure has been associated with increased all-cause, cancer, and cardiovascular disease mortality...
  32. ncbi Cadmium stress: an oxidative challenge
    Ann Cuypers
    Centre for Environmental Sciences, Hasselt University, Agoralaan Building D, Diepenbeek, Belgium
    Biometals 23:927-40. 2010
    At the cellular level, cadmium (Cd) induces both damaging and repair processes in which the cellular redox status plays a crucial role...
  33. ncbi Cadmium inhibits the electron transfer chain and induces reactive oxygen species
    Yudong Wang
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Free Radic Biol Med 36:1434-43. 2004
    Recent research indicates that cadmium (Cd) induces oxidative damage in cells; however, the mechanism of the oxidative stress induced by this metal is unclear...
  34. ncbi ERK and cell death: cadmium toxicity, sustained ERK activation and cell death
    Patrick Martin
    CNRS FRE3094, Universite de Nice Sophia Antipolis, Nice, France
    FEBS J 277:39-46. 2010
    ..Here, we review the role of ERK in cell response to cadmium and its association with cell toxicity...
  35. pmc Metallothionein protection of cadmium toxicity
    Curtis D Klaassen
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Toxicol Appl Pharmacol 238:215-20. 2009
    The discovery of the cadmium (Cd)-binding protein from horse kidney in 1957 marked the birth of research on this low-molecular weight, cysteine-rich protein called metallothionein (MT) in Cd toxicology...
  36. ncbi Does prenatal cadmium exposure affect fetal and child growth?
    Chien Mu Lin
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK
    Occup Environ Med 68:641-6. 2011
    b>Cadmium is known to be a significant health hazard, but most information comes from studies of adults. The effects of exposure to cadmium during fetal life on early growth and development remain uncertain...
  37. pmc Maternal cadmium exposure during pregnancy and size at birth: a prospective cohort study
    Maria Kippler
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Environ Health Perspect 120:284-9. 2012
    b>Cadmium (Cd) is an embryotoxic and teratogenic metal in a variety of animal species, but data from humans are limited.
  38. ncbi Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals
    Jean Marc Moulis
    Laboratoire de Chimie et Biologie des Metaux, CEA Grenoble, DSV, iRTSV, 17 rue des Martyrs, Grenoble Cedex 9, France
    Biometals 23:877-96. 2010
    The widespread occurrence of cadmium in the environment continues to pose a threat to human health despite attempts at limiting its technological uses...
  39. pmc Regulatory networks of cadmium stress in plants
    Giovanni DalCorso
    Dipartimento di Biotecnologie, Universita degli Studi di Verona, Verona, Italy
    Plant Signal Behav 5:663-7. 2010
    During their life, plants have to cope with a variety of abiotic stresses. Cadmium is highly toxic to plants, water soluble and therefore promptly adsorbed in tissues and its presence greatly influences the entire plant metabolism...
  40. ncbi Effects of long-term low-dose cadmium exposure on genomic DNA methylation in human embryo lung fibroblast cells
    Gaofeng Jiang
    Faculty of Preventive Medicine, Medical College, Wuhan University of Science and Technology, Huangjiahu Campus, Wuhan 430065, Hubei Province, People s Republic of China
    Toxicology 244:49-55. 2008
    b>Cadmium is a toxic transition metal of continuing occupational and environmental concern. As a well-recognized human carcinogen, its carcinogenic mechanisms are still poorly understood...
  41. pmc Expression of arabidopsis CAX2 in tobacco. Altered metal accumulation and increased manganese tolerance
    K D Hirschi
    Baylor College of Medicine, Plant Physiology Group, United States Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Houston, Texas 77030, USA
    Plant Physiol 124:125-33. 2000
    ..These results suggest that CAX2 has a broad substrate range and modulation of this transporter may be an important component of future strategies to improve plant ion tolerance...
  42. ncbi Cadmium induces reactive oxygen species generation and lipid peroxidation in cortical neurons in culture
    E Lopez
    Instituto de Bioquímica Centro Mixto CSIC UCM, Facultad de Farmacia, 28040 Madrid, Spain
    Free Radic Biol Med 40:940-51. 2006
    b>Cadmium is a toxic agent that it is also an environmental contaminant. Cadmium exposure may be implicated in some humans disorders related to hyperactivity and increased aggressiveness...
  43. pmc Cadmium exposure in pregnancy and lactation in relation to iron status
    Agneta Akesson
    Institute of Environmental Medicine, Division of Metals and Health, Karolinska Institutet, Stockholm, Sweden
    Am J Public Health 92:284-7. 2002
    The purpose of this study was to determine the impact of iron status on cadmium dose among pregnant women.
  44. pmc Molecular and ionic mimicry and the transport of toxic metals
    Christy C Bridges
    Division of Basic Medical Sciences, Mercer University School of Medicine, Macon, GA 31207, USA
    Toxicol Appl Pharmacol 204:274-308. 2005
    ..This review will present the established and putative roles of molecular and ionic mimicry in the transport of mercury, cadmium, lead, arsenic, selenium, and selected oxyanions in target organs and tissues.
  45. ncbi Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4
    Marc Hanikenne
    Max Planck Institute of Molecular Plant Physiology, D 14476 Potsdam, Germany
    Nature 453:391-5. 2008
    ..A. halleri naturally accumulates and tolerates leaf concentrations as high as 2.2% zinc and 0.28% cadmium in dry biomass. On the basis of transcriptomics studies, metal hyperaccumulation in A...
  46. ncbi Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5
    Long Chen
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
    Free Radic Biol Med 45:1035-44. 2008
    b>Cadmium (Cd), a highly toxic environmental pollutant, induces neurodegenerative diseases...
  47. ncbi How plants cope with cadmium: staking all on metabolism and gene expression
    Giovanni DalCorso
    Dipartimento Scientifico e Tecnologico, Universita degli Studi di Verona, Strada Le Grazie 15, 37134 Verona, Italy
    J Integr Plant Biol 50:1268-80. 2008
    ..Soil contamination by heavy metals as cadmium, highlights two main aspects: on one side they interfere with the life cycle of plants and therefore reduce crop ..
  48. pmc Cadmium is a mutagen that acts by inhibiting mismatch repair
    Yong Hwan Jin
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Nat Genet 34:326-9. 2003
    ..We found that chronic exposure of yeast to environmentally relevant concentrations of cadmium, a known human carcinogen, can result in extreme hypermutability...
  49. ncbi Urinary cadmium levels and tobacco smoke exposure in women age 20-69 years in the United States
    J A McElroy
    University of Wisconsin, Paul P Carbone Comprehensive Cancer Center, Madison, Wisconsin 53726, USA
    J Toxicol Environ Health A 70:1779-82. 2007
    b>Cadmium is a toxic, bioaccumulated heavy metal with a half-life of one to four decades in humans (CDC, 2005). Primary exposure sources include food and tobacco smoke...
  50. ncbi Long-term dietary cadmium intake and cancer incidence
    Norie Sawada
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Epidemiology 23:368-76. 2012
    b>Cadmium, a ubiquitous environmental pollutant, is classified as a carcinogenic substance...
  51. ncbi Associations between dietary cadmium exposure and bone mineral density and risk of osteoporosis and fractures among women
    Annette Engström
    Institute of Environmental Medicine, Karolinska Institutet, Box 210, S 171 77 Stockholm, Sweden
    Bone 50:1372-8. 2012
    Osteoporosis and its main health outcome, fragility fractures, are large and escalating public health problems. Cadmium, a widespread food contaminant, is a proposed risk factor; still the association between estimated dietary cadmium ..
  52. pmc Cadmium exposure and all-cause and cardiovascular mortality in the U.S. general population
    Maria Tellez-Plaza
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Environ Health Perspect 120:1017-22. 2012
    Urine cadmium concentrations were associated with all-cause and cardiovascular mortality in men in the 1988-1994 U.S. National Health and Nutrition Examination Survey (NHANES) population...
  53. pmc Dietary cadmium and risk of invasive postmenopausal breast cancer in the VITAL cohort
    Scott V Adams
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Cancer Causes Control 23:845-54. 2012
    The aim of the study was to estimate the association between dietary intake of cadmium, a carcinogenic heavy metal, and risk of invasive postmenopausal breast cancer.
  54. ncbi Cadmium and cardiovascular diseases: cell biology, pathophysiology, and epidemiological relevance
    Barbara Messner
    Cardiothoracic Surgery, Research Laboratories, Department of Surgery, Medical University of Vienna, Wahringer Gurtel 18 20, Vienna, Austria
    Biometals 23:811-22. 2010
    ..b>Cadmium (Cd) was shown to have the potential to serve as one such novel risk factor, as it was demonstrated-in vitro, in ..
  55. pmc Root-to-shoot Cd translocation via the xylem is the major process determining shoot and grain cadmium accumulation in rice
    Shimpei Uraguchi
    Soil Environment Division, National Institute for Agro Environmental Sciences, 3 1 3 Kannondai, Tsukuba, Ibaraki, 305 8604, Japan
    J Exp Bot 60:2677-88. 2009
    Physiological properties involved in divergent cadmium (Cd) accumulation among rice genotypes were characterized using the indica cultivar 'Habataki' (high Cd in grains) and the japonica cultivar 'Sasanishiki' (low Cd in grains)...
  56. pmc Cadmium induces carcinogenesis in BEAS-2B cells through ROS-dependent activation of PI3K/AKT/GSK-3β/β-catenin signaling
    Young Ok Son
    Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536 0305, USA
    Toxicol Appl Pharmacol 264:153-60. 2012
    b>Cadmium has been widely used in industry and is known to be carcinogenic to humans...
  57. pmc Genome-wide association studies identify heavy metal ATPase3 as the primary determinant of natural variation in leaf cadmium in Arabidopsis thaliana
    Dai Yin Chao
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK
    PLoS Genet 8:e1002923. 2012
    Understanding the mechanism of cadmium (Cd) accumulation in plants is important to help reduce its potential toxicity to both plants and humans through dietary and environmental exposure...
  58. ncbi Oxidative stress and apoptotic changes of rat cerebral cortical neurons exposed to cadmium in vitro
    Yuan Yan
    College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China
    Biomed Environ Sci 25:172-81. 2012
    To investigate the cytotoxic mechanism of cadmium (Cd) on cerebral cortical neurons.
  59. ncbi Time trends in burdens of cadmium, lead, and mercury in the population of northern Sweden
    Maria Wennberg
    Department of Medicine, Skellefteå Hospital, 931 86 Skellefteå, Sweden
    Environ Res 100:330-8. 2006
    ..This study addresses time trends for the three toxic elements cadmium (Cd), mercury (Hg), and lead (Pb)...
  60. pmc Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke
    Soisungwan Satarug
    National Research Centre for Environmental Toxicology, The University of Queensland, Brisbane, Queensland, Australia
    Environ Health Perspect 112:1099-103. 2004
    b>Cadmium is a cumulative nephrotoxicant that is absorbed into the body from dietary sources and cigarette smoking...
  61. ncbi Heavy metals (lead, cadmium and mercury) in maternal, cord blood and placenta of healthy women
    Iman Al-Saleh
    Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia
    Int J Hyg Environ Health 214:79-101. 2011
    Lead, cadmium and mercury were measured in placental tissue, umbilical cord and maternal blood samples of 1578 women who delivered at the Al-Kharj King Khalid Hospital between 2005 and 2006...
  62. pmc Environmental cadmium and breast cancer risk
    Carolyn M Gallagher
    Doctoral Program in Population Health and Clinical Outcomes Research, Stony Brook University, Stony Brook, NY 11794, USA
    Aging (Albany NY) 2:804-14. 2010
    Breast cancer is the most prevalent women's cancer, with an age-adjusted incidence of 122.9 per 100,000 US women. Cadmium, a ubiquitous carcinogenic pollutant with multiple biological effects, has been reported to be associated with ..
  63. ncbi Urinary cadmium, impaired fasting glucose, and diabetes in the NHANES III
    Gary G Schwartz
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Diabetes Care 26:468-70. 2003
    Increasing rates of type 2 diabetes worldwide suggest that diabetes may be caused by environmental toxins. Cadmium is a widespread environmental pollutant that accumulates in the pancreas and exerts diabetogenic effects in animals...
  64. pmc Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase
    Lamia Benbrahim-Tallaa
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 115:1454-9. 2007
    ..The typical pattern appears to involve reduced expression of maintenance DNA methyltransferase, DNMT1, inducing genomic hypomethylation, whereas increased expression of de novo DNMT3a or 3b causes gene-specific hypermethylation...
  65. ncbi Mechanisms to cope with arsenic or cadmium excess in plants
    Nathalie Verbruggen
    Laboratoire de Physiologie et de Génétique Moléculaire des Plantes, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, Brussels, Belgium
    Curr Opin Plant Biol 12:364-72. 2009
    The metalloid arsenic and the heavy metal cadmium have no demonstrated biological function in plants. Both elements are highly toxic and of major concern with respect to their accumulation in soils, in the food-chain or in drinking water...
  66. ncbi Cadmium-free CuInS2/ZnS quantum dots for sentinel lymph node imaging with reduced toxicity
    Thomas Pons
    Laboratoire Physique et Etude des Materiaux, CNRS UPR0005, ESPCI, 10 rue Vauquelin, 75005 Paris, France
    ACS Nano 4:2531-8. 2010
    ....
  67. ncbi Accumulation of cadmium in human placenta interacts with the transport of micronutrients to the fetus
    Maria Kippler
    Institute of Environmental Medicine, Division of Metals and Health, Karolinska Institutet, Stockholm, Sweden
    Toxicol Lett 192:162-8. 2010
    b>Cadmium (Cd) is a widespread, highly toxic environmental pollutant known to accumulate in human placenta...
  68. ncbi Burden of cadmium in early childhood: longitudinal assessment of urinary cadmium in rural Bangladesh
    Maria Kippler
    Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE 17177 Stockholm, Sweden
    Toxicol Lett 198:20-5. 2010
    Chronic cadmium exposure is associated with many adverse health effects in adults, but little is known about the scenario early in life...
  69. ncbi Sublethal cadmium intoxication in Arabidopsis thaliana impacts translation at multiple levels
    R Sormani
    Aix Marseille Universite, Laboratoire de Genetique et Biophysique des Plantes, F 13009 Marseille, France
    Plant Cell Physiol 52:436-47. 2011
    ..regulation during heavy metal poisoning, Arabidopsis thaliana cell cultures were submitted to sublethal cadmium stress...
  70. ncbi Mitochondria, reactive oxygen species and cadmium toxicity in the kidney
    Glenda Gobe
    Centre for Kidney Disease Research, University of Queensland School of Medicine, Princess Alexandra Hospital, Woolloongabba, Brisbane 4102, Australia
    Toxicol Lett 198:49-55. 2010
    The heavy metal cadmium accumulates in kidney cells, particularly those of the proximal tubular epithelium, and the damage this causes is associated with development of chronic kidney disease...
  71. ncbi Role of cadmium in the regulation of AR gene expression and activity
    Mary Beth Martin
    Department of Biochemistry and Molecular Biology, Lombardi Cancer Center, E411 Research Building, 3970 Reservoir Road NW, Washington, D C 20007
    Endocrinology 143:263-75. 2002
    Treatment of human prostate cancer cells, LNCaP, with cadmium stimulated cell growth. There was a 2.4-fold increase in the population of cells in the S + G(2)M phase by d 4 and a 2.7-fold increase in cell number by d 8...
  72. ncbi Long-term dietary cadmium intake and postmenopausal endometrial cancer incidence: a population-based prospective cohort study
    Agneta Akesson
    Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Cancer Res 68:6435-41. 2008
    ..A potent estrogen-like activity of the pollutant cadmium, mediated via the estrogen receptor-alpha, has been shown in vivo...
  73. pmc Calcium signaling is involved in cadmium-induced neuronal apoptosis via induction of reactive oxygen species and activation of MAPK/mTOR network
    Baoshan Xu
    Department of Biochemistry and Molecular Biology, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
    PLoS ONE 6:e19052. 2011
    b>Cadmium (Cd), a toxic environmental contaminant, induces oxidative stress, leading to neurodegenerative disorders...
  74. ncbi Cadmium exposure and breast cancer risk
    Jane A McElroy
    University of Wisconsin Comprehensive Cancer Center, Room 307 WARF, 610 Walnut St, Madison, WI 53726, USA
    J Natl Cancer Inst 98:869-73. 2006
    b>Cadmium, a highly persistent heavy metal, has been categorized as a probable human carcinogen by the U.S. Environmental Protection Agency. Primary exposure sources include food and tobacco smoke...
  75. ncbi Caspase-dependent and -independent pathways for cadmium-induced apoptosis in cultured kidney proximal tubule cells
    Wing Kee Lee
    Department of Physiology and Pathophysiology, Faculty of Medicine, University of Witten Herdecke, Witten, Germany
    Am J Physiol Renal Physiol 291:F823-32. 2006
    The nephrotoxic metal cadmium at micromolar concentrations induces apoptosis of rat kidney proximal tubule (PT) cells within 3-6 h of exposure. The underlying cell death pathways remain poorly defined...
  76. pmc Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis
    Timothy P Dalton
    Department of Environmental Health and the Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Proc Natl Acad Sci U S A 102:3401-6. 2005
    Testicular necrosis is a sensitive endpoint for cadmium (Cd(2+), Cd) toxicity across all species tested. Resistance to Cd-induced testicular damage is a recessive trait assigned to the Cdm locus on mouse chromosome 3...
  77. ncbi Cadmium and mitochondria
    Giuseppe Cannino
    Dipartimento di Biologia Cellulare e dello Sviluppo A Monroy, University of Palermo, Italy
    Mitochondrion 9:377-84. 2009
    The heavy metal cadmium (Cd) a pollutant associated with several modern industrial processes, is absorbed in significant quantities from cigarette smoke, water, food and air contaminations...
  78. pmc Cadmium exposure and hypertension in the 1999-2004 National Health and Nutrition Examination Survey (NHANES)
    Maria Tellez-Plaza
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe St, Rm W7033B, Baltimore, MD 21205, USA
    Environ Health Perspect 116:51-6. 2008
    b>Cadmium induces hypertension in animal models. Epidemiologic studies of cadmium exposure and hypertension, however, have been inconsistent.
  79. ncbi Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium
    Daniel Stewart
    Department of Molecular Genetics, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    J Biol Chem 278:2396-402. 2003
    ..b>Cadmium did not significantly affect the steady-state level of Nrf2 mRNA or the initial rate of Nrf2 protein synthesis ..
  80. ncbi Status of toxic metals in biological samples of diabetic mothers and their neonates
    Nida Fatima Kolachi
    Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro 76080, Pakistan
    Biol Trace Elem Res 143:196-212. 2011
    ..The aim of present study was to compare the status of trace toxic elements, arsenic (As), cadmium (Cd), and lead (Pb) in biological samples (whole blood, urine and scalp hair) of insulin-dependent diabetic ..
  81. pmc Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance
    David G Mendoza-Cózatl
    Division of Biological Sciences, Cell and Developmental Biology Section, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:40416-26. 2010
    ..Abc2 expression restores phytochelatin accumulation into vacuoles and suppresses the cadmium sensitivity of the abc quintuple mutant...
  82. pmc CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal cell death
    Sujuan Chen
    College of Life Sciences, Nanjing Normal University, Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, Nanjing, China
    J Neurochem 119:1108-18. 2011
    b>Cadmium (Cd), a toxic environmental contaminant, induces neurodegenerative diseases...
  83. ncbi Cadmium interacts with the transport of essential micronutrients in the mammary gland - a study in rural Bangladeshi women
    Maria Kippler
    Division of Metals and Health, Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE 171 77 Stockholm, Sweden
    Toxicology 257:64-9. 2009
    Although the concentrations of the toxic metal cadmium in breast milk are generally low (< 1 microg/L), experimental studies indicated neurobehavioral and endocrine effects in the suckling offspring...
  84. ncbi Tight steric closure at the intracellular activation gate of a voltage-gated K(+) channel
    D del Camino
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 32:649-56. 2001
    ..Either these Kv channels have a broader inner entrance than seen in the KcsA crystal, even in the closed state, or the region is highly flexible (but nevertheless remains very securely closed nearby)...
  85. ncbi Microsporidia parasites disrupt the responses to cadmium exposure in a gammarid
    Eric Gismondi
    Laboratoire des Interactions Ecotoxicologie Biodiversité Ecosystèmes LIEBE, Universite Paul Verlaine Metz, CNRS UMR 7146, Campus Bridoux, Avenue du général Delestraint, 57070 Metz, France
    Environ Pollut 160:17-23. 2012
    ..the effect of microsporidian infections on energy reserves and defence capacities of Gammarus roeseli under cadmium stress. Only females were infected by two microsporidia parasites: Dictyocoela roeselum or Dictyocoela muelleri...
  86. ncbi Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells. Role of p38 kinase and Nrf2 transcription factor
    J Alam
    Department of Molecular Genetics, Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121, USA
    J Biol Chem 275:27694-702. 2000
    ..SB203580, an inhibitor of p38, diminishes cadmium-stimulated pE1-luc expression and HO-1 mRNA levels by up to 70-80%...
  87. ncbi Cadmium as a transcriptional modulator in human cells
    Claudio Luparello
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, Palermo, Italy
    Crit Rev Toxicol 41:75-82. 2011
    b>Cadmium (Cd) is an underground mineral widely used in the steel industry, in plastics, and as a component of batteries...
  88. ncbi Cadmium and cellular signaling cascades: to be or not to be?
    Frank Thevenod
    Department of Physiology and Pathophysiology, University of Witten Herdecke, Witten, Germany
    Toxicol Appl Pharmacol 238:221-39. 2009
    The cellular effects of the toxic metal cadmium (Cd) are manifold. A large proportion of the cellular reactions affected by ionic Cd(2+) are mediated by cellular signaling cascades...
  89. pmc Renal and neurologic effects of cadmium, lead, mercury, and arsenic in children: evidence of early effects and multiple interactions at environmental exposure levels
    Claire de Burbure
    Unit of Industrial Toxicology and Occupational Medicine, Faculty of Medicine, Catholic University of Louvain, Clos Chapelle aux Champs 30, B 1200 Brussels, Belgium
    Environ Health Perspect 114:584-90. 2006
    Lead, cadmium, mercury, and arsenic are common environmental pollutants in industrialized countries, but their combined impact on children's health is little known...
  90. ncbi Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges
    Sarah M Webster
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 428:864-8. 2004
    ..A narrower opening of the bundle crossing in Shaker K+ channels may help to explain why Shaker has an approximately tenfold lower conductance than its bacterial relatives...
  91. ncbi Metal-induced apoptosis: mechanisms
    Marisa D Pulido
    Department of Medical Pharmacology and Toxicology, College of Medicine, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
    Mutat Res 533:227-41. 2003
    ..our current understanding of the apoptotic pathways that are initiated by metals, mainly established (arsenic, cadmium, chromium, nickel, beryllium) and possible (lead, antimony, cobalt) human carcinogens...
  92. ncbi Multiple roles of cadmium in cell death and survival
    Douglas M Templeton
    University of Toronto, Canada
    Chem Biol Interact 188:267-75. 2010
    b>Cadmium is a toxic metal with no known biological function. It is increasingly important as an environmental hazard to both humans and wildlife, and it exemplifies the double edged nature of many toxic substances...
  93. pmc Cadmium regulates the expression of the CFTR chloride channel in human airway epithelial cells
    Jessica Rennolds
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Toxicol Sci 116:349-58. 2010
    b>Cadmium is a toxic heavy metal ranked seventh on the Priority List of Hazardous Substances. As a byproduct of smelters, cadmium is a prevalent environmental contaminant...
  94. ncbi Root responses to cadmium in the rhizosphere: a review
    Alexander Lux
    Department of Plant Physiology, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina B2, 842 15 Bratislava, Slovakia
    J Exp Bot 62:21-37. 2011
    This article reviews the responses of plant roots to elevated rhizosphere cadmium (Cd) concentrations. Cadmium enters plants from the soil solution...
  95. pmc Nitric oxide is involved in cadmium-induced programmed cell death in Arabidopsis suspension cultures
    Roberto De Michele
    Dipartimento di Biologia, Universita degli Studi di Padova, I 35131 Padova, Italy
    Plant Physiol 150:217-28. 2009
    Exposure to cadmium (Cd(2+)) can result in cell death, but the molecular mechanisms of Cd(2+) cytotoxicity in plants are not fully understood...
  96. ncbi Interpreting NHANES biomonitoring data, cadmium
    Patricia Ruiz
    Agency for Toxic Substances and Disease Registry, Atlanta, GA 30333, USA
    Toxicol Lett 198:44-8. 2010
    b>Cadmium (Cd) occurs naturally in the environment and the general population's exposure to it is predominantly through diet...
  97. ncbi Cadmium-induced autophagy and apoptosis are mediated by a calcium signaling pathway
    S H Wang
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan, ROC
    Cell Mol Life Sci 65:3640-52. 2008
    The cytotoxicity of cadmium (Cd) induced autophagy and apoptosis in MES-13 cells was determined by flow cytometry. Autophagy was also assessed by formation of autophagosomes and processing of LC3...
  98. pmc Cadmium triggers an integrated reprogramming of the metabolism of Synechocystis PCC6803, under the control of the Slr1738 regulator
    Laetitia Houot
    Commissariat a l Energie Atomique, Institut de Biologie et Tecnologies de Saclay, Service de Biologie Intégrative et Génétique Moléculaire, CEA Saclay F 91191 Gif sur Yvette CEDEX, France
    BMC Genomics 8:350. 2007
    b>Cadmium is a persistent pollutant that threatens most biological organisms, including cyanobacteria that support a large part of the biosphere...
  99. ncbi The role of mercury and cadmium heavy metals in vascular disease, hypertension, coronary heart disease, and myocardial infarction
    Mark C Houston
    Vanderbilt University School of Medicine, USA
    Altern Ther Health Med 13:S128-33. 2007
    Mercury, cadmium, and other heavy metals have a high affinity for sulfhydryl (-SH) groups, inactivating numerous enzymatic reactions, amino acids, and sulfur-containing antioxidants (NAC, ALA, GSH), with subsequent decreased oxidant ..
  100. pmc Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity
    Yuxia Cui
    Nicholas School of the Environment and Earth Sciences, Duke University, Durham, NC 27708, USA
    Genome Biol 8:R122. 2007
    Exposure to cadmium is associated with a variety of human diseases. At low concentrations, cadmium activates the transcription of stress-responsive genes, which can prevent or repair the adverse effects caused by this metal.
  101. pmc Blood cadmium and lead and chronic kidney disease in US adults: a joint analysis
    Ana Navas-Acien
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Am J Epidemiol 170:1156-64. 2009
    Environmental cadmium and lead exposures are widespread, and both metals are nephrotoxic at high exposure levels...

Research Grants66

  1. Lung Lysyl Oxidase Regulation by Metal Ion Homeostasis
    Wande Li; Fiscal Year: 2013
    ..Chronic exposure of humans to cadmium (Cd), a heavy metal, either from occupational contamination or from cigarette smoke, induces emphysema and lung ..
  2. Analyzer for Monitoring Personal Environmental Exposure to Fluids and Materials
    MATTHEW CUSACK; Fiscal Year: 2010
    ..Abnormal levels of bio-essential metals (iron, copper, and zinc) as well as toxic trace elements (mercury, lead, cadmium, and arsenic) are known to be associated with many health disorders such as cancer, cognitive impairment, and ..
  3. Human developmental toxicity of metal mixture exposure from e-waste recycling
    Aimin Chen; Fiscal Year: 2010
    ..E-waste contains high levels of several metals (lead [Pb], mercury [Hg], cadmium [Cd], chromium [Cr], manganese [Mn], etc...
  4. Role of Physico-chemical Properties in the Reprotoxicity of Inhaled Cd NP.
    JUDITH TERRY ZELIKOFF; Fiscal Year: 2010
    ..Most non-carbon NP contain one or more toxicologically-active metals, including cadmium (Cd)...
  5. Epidemiological Research on Autism in Jamaica
    Mohammad H Rahbar; Fiscal Year: 2010
    ..and sex matched case-control study to investigate whether environmental exposures to mercury, lead, arsenic and cadmium play a role in autism...
  6. Continuation of FERN Activities at the Connecticut Agricultural Experiment Statio
    LAURIE J PETERSON-WRIGHT; Fiscal Year: 2013
    ..Our elemental experience has ranged from the determination of lead in maple syrup to cadmium in fish tissue to nanoparticles in vegetables...
  7. Epidemiological Research on Autism in Jamaica - Phase II
    Mohammad H Rahbar; Fiscal Year: 2013
    ..investigate the role of the glutathione-S-transferase (GST) genes and five heavy metals (lead, mercury, arsenic, cadmium, manganese) in relation to ASD...
  8. Soft Metal, Disulfide, and Cysteine Stresses in Escherichia coli
    James A Imlay; Fiscal Year: 2013
    ..Preliminary data demonstrate that silver, mercury, cadmium, and zinc have this effect in vitro, too...
  9. Dual Modality System for Imaging Colon Cancer in Mice
    Jennifer Kehlet Barton; Fiscal Year: 2013
    ..Gold nanoparticles will be used as OCT reporters. LIF reporters will include cyanine dyes, cadmium-free nanodots, and upconverting lanthanide particles. 3. Perform chemoprevention and chemotherapeutic studies...
  10. Toxic Metal Complexation by de Novo Designed Peptides
    Vincent L Pecoraro; Fiscal Year: 2013
    Abstract Heavy metal poisoning by elements such as mercury, lead, cadmium, and arsenic is a significant human health problem...
  11. Divalent metal-ion transporter DMT1 and its role in intestinal metal-ion uptake
    Bryan Mackenzie; Fiscal Year: 2012
    ..Important for this proposal, iron deficiency is a serious risk factor for cadmium intoxication, suggesting that cadmium and iron share a common absorptive mechanism...
  12. Selenium, other risk factors and cognitive decline in rural elderly Chinese
    Sujuan Gao; Fiscal Year: 2013
    ..We also reported that higher plasma calcium level was associated with higher cognitive scores. Higher plasma cadmium and copper levels, on the other hand, were associated with lower cognitive scores...
  13. Toxic metals and ion channels in cigarette-smoke induced COPD
    ESTELLE A CORMET BOYAKA; Fiscal Year: 2010
    Cigarette smoke (CS) is well known to induce chronic obstructive pulmonary disease (COPD) and cancer in humans. Cadmium is the most abundant toxic heavy metal that is present in CS...
  14. Chronic Cadmium Exposure Promotes Breast Cancer Progression
    Maggie C Louie; Fiscal Year: 2012
    ..development of hormone refractory breast cancer may involve endocrine disruptors, including heavy metals such as cadmium. Cadmium is an environmental contaminant that enters the body through the diet or cigarette smoke...
  15. New Optics for Trace Level Detection of Toxins in Environmental and Biological Sa
    ZEWU CHEN; Fiscal Year: 2010
    ..Two of the most difficult elements for XRF are cadmium (Cd) and antimony (Sb)...
  16. Field-Deployable Monitor to Assess Personal Exposure to Multiple Heavy Metals
    BADAWI M DWEIK; Fiscal Year: 2010
    ..is to develop a portable, self-contained, easy-to-use monitor for simultaneous on-site measurement of arsenic, cadmium, manganese and lead metals from a single urine sample, in near real time, to assess personal exposure...
  17. Biomarker signatures of biological, chemical, or psychological stress
    David A Lawrence; Fiscal Year: 2010
    ..innate immune processes, will then be quantified in humanized mice after exposure to three prototype stressors: cadmium, cold-restraint, and listerial infection...
  18. Mechanistic insights into cellular metal detoxification
    Jaekwon Lee; Fiscal Year: 2013
    ..For example, cadmium is a highly toxic environmental contaminant and implicated in disorders, including kidney failure, cancer, ..
  19. Environmental exposure to metal mixtures and kidney disease
    Mary Fox; Fiscal Year: 2009
    ..We will examine metal mixture exposures in a representative sample of the US population. The metals are barium, cadmium, cobalt, lead, mercury, molybdenum, and uranium...
  20. Role of SGLT3 in diabetes-mediated increased renal sodium reabsorption
    Niloofar M Tabatabai; Fiscal Year: 2013
    ..We also showed while mRNA levels of SGLT3s in cultured mouse primary kidney cells exposed to cadmium were several folds higher than in their levels in untreated cells, the sodium-dependent uptake of glucose in Cd-..
  21. Pilot assessment of the effects of noise, lead, and cadmium on hearing in mice
    Richard L Neitzel; Fiscal Year: 2013
    ..A limited but highly suggestive body of research suggests that exposures to lead (Pb) and cadmium (Cd) - both common environmental contaminants in the United States and worldwide - may be associated with an ..
  22. Colloidal Quantum Dot/Well Near-Infrared NanoLabels
    Hua Mao; Fiscal Year: 2010
    ..aims to develop a novel class of commercial products of near infrared (NIR) nanolabels based on colloidal non-cadmium quantum dots, InAs/InP/ZnSe core/shell/shell dots coated with dendron ligands...
  23. Chemical Exposures and Infant Outcomes in the Neonatal Intensive Care Unit
    Annemarie Stroustrup; Fiscal Year: 2013
    ..3) apply the lessons learned to a research project examining biomarkers of exposure to phthalates, phenols, cadmium, and manganese and infant medical and neurobehavioral development...
  24. Automatic Multi-Analyte in-Situ Bioassay for Monitoring Exposure to Toxic Materia
    Jianwei Mo; Fiscal Year: 2010
    ..instrument used with disposable silicon microchips to provide rapid, in-field simultaneous detection of lead, cadmium, and zinc in a single sub-microliter blood sample...
  25. Urinary cadmium and risk of breast cancer
    Jaymie R Meliker; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cadmium is a heavy metal that occurs naturally in the environment...
  26. HYPOXIC EFFECTS ON MAMMALIAN RESPIRATORY NEURAL NETWORK
    JAN M RAMIREZ; Fiscal Year: 2010
    ..configurations during normoxia and severe hypoxia: In normoxia the respiratory network is complex and contains cadmium-sensitive (CS) pacemakers, cadmium-insensitive (CI) pacemakers, and three different types of inspiratory ..
  27. Dietary and Environmental Exposure to Cadmium and the Risk of Endometrial Cancer
    Rudolph P Rull; Fiscal Year: 2012
    ..b>Cadmium is a trace metal released into air and soil as a byproduct of industrial processes and is perhaps the most potent ..
  28. Gene-Environment Interaction of ZnT8 and Cadmium - A Link to Diabetes Mellitus?
    Malek El Muayed; Fiscal Year: 2013
    ..b>Cadmium has been shown to compete with zinc in several cellular trafficking systems and protein binding sites...
  29. Trace element levels and risk of stroke
    Leslie Ain McClure; Fiscal Year: 2013
    ..The proposed study will focus on arsenic, cadmium, mercury, magnesium and selenium...
  30. Energy-Independent Single Photon Molecular Imaging Technology
    Youngho Seo; Fiscal Year: 2013
    ..a completely new single photon emission computed tomography (SPECT) system using novel technologies employing cadmium zinc telluride (CZT), customized application-specific integrated circuit (ASIC), innovative collimator design, ..
  31. Low-cost Large-area High-Sensitivity X-ray Panel Detector for Digital Mammography
    NEAL EUGENE HARTSOUGH; Fiscal Year: 2010
    ..By growing polycrystalline CZT (cadmium zinc telluride) films directly onto custom CMOS readouts, we will create large area panels with high resolution ..
  32. Role of Nrf2 in immunotoxicity by food additives and environmental contaminants
    CHERYL ELIZABETH ROCKWELL; Fiscal Year: 2013
    ..Nrf2 is activated by a variety of chemicals, including environmental contaminants such as arsenic, cadmium, nickel, cigarette smoke, and diesel exhaust, as well as industrial byproducts, such as tetrafluoroethylcysteine...
  33. Role of Valosin-Containing Protein (VCP/p97) in Cadmium-Disturbed Proteostasis
    Changcheng Song; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cadmium (Cd2+) poisoning is a serious health threat due to increased level of environmental pollution and lack of effective therapy...
  34. Lead, Cadmium,Arsenic, and cardiovascular risk in children
    Eliseo Guallar; Fiscal Year: 2011
    ..It is based upon a growing epidemiological literature, by us and others, indicating that exposure to lead, cadmium, or arsenic increases cardiovascular risk...
  35. PAH Bioremediation and Monitoring in Biowalls
    Paul Bishop; Fiscal Year: 2009
    ..PAHs are usually accompanied at these sites by heavy metals such as arsenic and cadmium. Unfortunately, little is known about the interactions between PAHs and heavy metals and the effect the presence ..
  36. Cadmium Exposure and Risk of Breast Cancer in the Women's Health Initiative
    Polly A Newcomb; Fiscal Year: 2013
    ..Multiple lines of evidence suggest that cadmium, a widespread and persistent heavy metal environmental pollutant, is a carcinogen in breast tissue, but more ..
  37. Childhood health disparities: exploration of prenatal exposures in primary teeth
    Andrea E Cassidy-Bushrow; Fiscal Year: 2013
    ..WHEALS participants, 250 naturally shed primary teeth (230 unique children) will be collected and 5 metals (lead, cadmium, manganese, mercury, arsenic) will be measured with LA-ICP-MS...
  38. Simultaneous SPECT/CT with a single photon counting camera
    William C Barber; Fiscal Year: 2011
    ..detectors These advances, along with improvements to the cost and reliability of the compound semiconductor cadmium telluride (CdTe), allow us to develop a photon counting detector and read-out technology for higher spatial ..
  39. Cardiovascular Effects of Environmental Cadmium Exposure
    Katherine A James; Fiscal Year: 2013
    ..Early epidemiologic and well-established mechanistic evidence suggest that cadmium may be an important risk factor in cardiovascular disease...
  40. Effects of environmental contamination on gene copy number variation: Molecular b
    Joseph Shaw; Fiscal Year: 2013
    ..Mutation accumulation (MA) lines derived in the absence and presence of cadmium will be used to define the spectra of CNV and measure the per generation rate at which they spontaneously arise ..
  41. End-to-End Optimization of SPECT Instrumentation, Acquisition, and Reconstruction
    Jonathan M Links; Fiscal Year: 2013
    ..Some of these are based on cadmium zinc telluride semiconductor detectors that provide improved full-width at half maximum energy resolution, but ..
  42. Development of a lab-on-a-chip for point-of-care biomonitoring of blood metals
    Ian Papautsky; Fiscal Year: 2013
    ..Biomarkers of pediatric, low-level, mixed exposures to lead (Pb), manganese (Mn), and cadmium (Cd) are essential...
  43. Multi-Metal Chip for Point-of-Care Monitoring in Children
    Ian Papautsky; Fiscal Year: 2011
    ..rapid and accurate point- of-care measurement of blood metal concentration, including manganese (Mn), zinc (Zn), cadmium (Cd), and lead (Pb) in children...
  44. INHALED PARTICLE CHARACTERISTICS AND EARLY LUNG EFFECTS
    William Beckett; Fiscal Year: 2002
    ..shown an excess of COPD associated with dusty work environments, yet only a few substances (coal, silica, cadmium) causing COPD in the workplace have been characterized based on chemical composition and respirable particle size...
  45. High Performance Multi-Modality Small Animal Imaging System
    Benjamin M W Tsui; Fiscal Year: 2013
    ..detectors and with 12 cm axial field-of- view, (2) a SPECT subsystem with 2 -head state-of-the-art solid-state cadmium zinc telluride (CZT) detector based camera modules with high-energy resolution that is especially important for ..
  46. Novel Chelators for Highly Efficient Removal of Toxic Heavy Metals in Humans
    Charles Timchalk; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Exposure to toxic metals like cadmium (Cd), lead (Pb), mercury (Hg), chromate (CrO42-), arsenite (As) (III), and arsenate (AsO43-) are known to induce various diseases that are detrimental to human ..
  47. Catalytic DNA Biosensor for Toxic Metal Ions
    Yi Lu; Fiscal Year: 2009
    ..Cost-effective catalytic DNA biosensors for heavy metal ions such as lead(II), uranium(VI), mercury(II), and cadmium(II) will be developed...
  48. FUNCTIONAL ANALYSIS OF A LEAD/CADMIUM/ZINC ATPASE
    Bharati Mitra; Fiscal Year: 2010
    ..essential trace metals like copper, zinc, cobalt and nickel, and mediate resistance to toxic metals such as lead, cadmium and silver...
  49. METAL CARCINOGEN-INDUCED MUTATIONS IN MAMMALIAN GENES
    EDWIN MURPHY; Fiscal Year: 1992
    ..g., compounds of nickel, chromium and cadmium) known to induce respiratory and bladder cancers as well as birth defects...
  50. Children's Environmental Health &Disease Prevention Research Center at Dartmouth
    MARGARET RITA KARAGAS; Fiscal Year: 2012
    ..g. cadmium and mercury.) on fetal development and maternal/infant immune function...
  51. MODULATION OF CHOROID PLEXUS CHOLINE TRANSPORT BY METALS
    Alice Villalobos; Fiscal Year: 2002
    ..The objective of this proposal is to characterize modulation of choroid plexus choline transport by zinc and cadmium as a means to predict the potential for heavy metals to alter choline availability in the brain...
  52. A SOCIAL NETWORK-BASED INTERVENTION TO REDUCE LEAD EXPOS
    Michelle Kegler; Fiscal Year: 2004
    ..The proposed research builds on previous work with these tribes, by expanding to address cadmium in addition to lead, and by adding a youth component...
  53. Phytoextraction of Cadmium from Plant Trichomes Expressing a Stabilized Antibody
    Ryan W Shepherd; Fiscal Year: 2012
    ..Small Business Innovation Research Phase I project will investigate the feasibility of utilizing a stabilized, cadmium-binding antibody to sequester cadmium in plant trichomes...
  54. Portable Analyzer for On-site Monitoring of Worker Exposure to Toxic Metals
    Charles Timchalk; Fiscal Year: 2007
    ..provided by applicant): Large numbers of industrial workers are regularly exposed to toxic heavy metals like cadmium (Cd), lead (Pb), and mercury (Hg), which are known to induce various diseases that are detrimental to human ..
  55. Steering Undergraduate Interest in Environmental Health Sciences at the Universit
    Donald A Sens; Fiscal Year: 2012
    ..the students will be involved in research that studies the role of the environmental pollutants, arsenic and cadmium, in the development and progression of human bladder, breast, prostate and renal disease...
  56. Environmental & Genetic Risk Factors for Renal Function
    Virginia Weaver; Fiscal Year: 2009
    ..exposures has received relatively little attention in this regard, despite the fact that exposures such as cadmium and lead are known renal toxicants that are stored long-term in the body and ubiquitous in humans...
  57. CADMIUM TOXICOLOGY
    Curtis Klaassen; Fiscal Year: 2000
    DESCRIPTION: (Adapted from the Investigator's Abstract) Cadmium (Cd) is an environmental pollutant with high toxic potential. Over half of the body burden of Cd is concentrated in liver and kidney and bound to metallothionein (MT)...
  58. ENVIRONMENTAL TOXICANT EFFECTS ON PERINATAL DEVELOPMENT
    Raymond Harbison; Fiscal Year: 1980
    The heavy metals mercury, metyl mercury, and cadmium perturb AIB transport across human placental syncytiotrophoblast tissue...
  59. Cadmium Cytoskeletal Toxicology in the Lung
    Iih Nan Chou; Fiscal Year: 2005
    b>Cadmium (Cd) is an established human lung carcinogen and causes severe injury to many other organs. Cd is widely used in industries and also occurs as an important environmental pollutant and an ingredient in cigarette...
  60. A mechanism of metal-mediated immunosuppression
    MICHAEL LYNES; Fiscal Year: 2007
    Heavy metal cations such as cadmium are widely found in the environment and can act as potent immunosuppressive agents. One of the biological responses to many immunosuppressive toxicants is the production of stress response proteins...
  61. Endothelial Progenitor Cells for Assessing Toxicological Response Variability in
    JOHN WILLIAM LUDLOW; Fiscal Year: 2013
    ..found at low levels in neonatal and adult peripheral blood: bisphenol A (BPA), perfluorooctanoic acid (PFOA), and cadmium. The proposed study is the key step in the development of a novel, robust, and comprehensive platform utilizing ..
  62. CADMIUM EFFECTS ON GENE EXPRESSION AND EMBRYOGENESIS
    Glen Andrews; Fiscal Year: 1990
    Heavy metals are extremely toxic environmental pollutants. Cadmium for example, can cause damage to liver and kidney, may increase the risk of cancer, and is embryotoxic and teratogenic...
  63. Catalytic DNA Biosensor for Toxic Metal Ions
    Yi Lu; Fiscal Year: 2005
    ..real-time, and cost-effective detection and quantification of multiple heavy metal ions, such as mercury, cadmium and lead, simultaneously will be explored...
  64. High Resolution SPECT-MR for Molecular Imaging
    Benjamin M W Tsui; Fiscal Year: 2010
    ..The main innovations include the use of state-of-the-art MR compatible cadmium zinc telluride (CZT) detector modules developed by our industrial partner, Gamma Medica-Ideas (GMI)...
  65. Quantum Dots for NIR Fluorescence Imaging of Tumor Angiogenesis
    Zhen Cheng; Fiscal Year: 2009
    ..the enthusiasm for further studies of these nanoconjugates is mitigated by the unfavorable in vivo kinetics and cadmium-based cytotoxicity of the traditional quantum dots...
  66. Biomarkers of Heavy Metal Exposure Related to Pancreatic Cancer Genetic Mutations
    AMR SOLIMAN; Fiscal Year: 2007
    ..in these areas, we propose to expand them to investigate possible association of elevated rates with exposure to cadmium in the wetlands and the Mississippi delta regions...