cadmium

Summary

Summary: An element with atomic symbol Cd, atomic number 48, and atomic weight 114. It is a metal and ingestion will lead to CADMIUM POISONING.

Top Publications

  1. doi Role of oxidative stress in cadmium toxicity and carcinogenesis
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 238:209-14. 2009
  2. doi Current status of cadmium as an environmental health problem
    Lars Jarup
    Department of Epidemiology and Public Health, Imperial College London, London, UK
    Toxicol Appl Pharmacol 238:201-8. 2009
  3. ncbi Hazards of heavy metal contamination
    Lars Jarup
    Department of Epidemiology and Public Health, Imperial College, London, UK
    Br Med Bull 68:167-82. 2003
  4. doi Cadmium stress: an oxidative challenge
    Ann Cuypers
    Centre for Environmental Sciences, Hasselt University, Agoralaan Building D, Diepenbeek, Belgium
    Biometals 23:927-40. 2010
  5. ncbi Gated access to the pore of a voltage-dependent K+ channel
    Y Liu
    Department of Neurobiology, Harvard Medical School and Massachusetts General Hospital, Boston 02114, USA
    Neuron 19:175-84. 1997
  6. pmc Microarray-based analysis of cadmium-responsive microRNAs in rice (Oryza sativa)
    Yanfei Ding
    State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou 310029, China
    J Exp Bot 62:3563-73. 2011
  7. doi Mitochondria, reactive oxygen species and cadmium toxicity in the kidney
    Glenda Gobe
    Centre for Kidney Disease Research, University of Queensland School of Medicine, Princess Alexandra Hospital, Woolloongabba, Brisbane 4102, Australia
    Toxicol Lett 198:49-55. 2010
  8. pmc Calcium signaling is involved in cadmium-induced neuronal apoptosis via induction of reactive oxygen species and activation of MAPK/mTOR network
    Baoshan Xu
    Department of Biochemistry and Molecular Biology, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
    PLoS ONE 6:e19052. 2011
  9. doi Molecular mechanisms of metal hyperaccumulation in plants
    Nathalie Verbruggen
    Universite Libre de Bruxelles, B 1050 Brussels, Belgium
    New Phytol 181:759-76. 2009
  10. pmc Metallothionein protection of cadmium toxicity
    Curtis D Klaassen
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Toxicol Appl Pharmacol 238:215-20. 2009

Detail Information

Publications350 found, 100 shown here

  1. doi Role of oxidative stress in cadmium toxicity and carcinogenesis
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 238:209-14. 2009
    b>Cadmium (Cd) is a toxic metal, targeting the lung, liver, kidney, and testes following acute intoxication, and causing nephrotoxicity, immunotoxicity, osteotoxicity and tumors after prolonged exposures...
  2. doi Current status of cadmium as an environmental health problem
    Lars Jarup
    Department of Epidemiology and Public Health, Imperial College London, London, UK
    Toxicol Appl Pharmacol 238:201-8. 2009
    b>Cadmium is a toxic metal occurring in the environment naturally and as a pollutant emanating from industrial and agricultural sources. Food is the main source of cadmium intake in the non-smoking population...
  3. ncbi Hazards of heavy metal contamination
    Lars Jarup
    Department of Epidemiology and Public Health, Imperial College, London, UK
    Br Med Bull 68:167-82. 2003
    The main threats to human health from heavy metals are associated with exposure to lead, cadmium, mercury and arsenic...
  4. doi Cadmium stress: an oxidative challenge
    Ann Cuypers
    Centre for Environmental Sciences, Hasselt University, Agoralaan Building D, Diepenbeek, Belgium
    Biometals 23:927-40. 2010
    At the cellular level, cadmium (Cd) induces both damaging and repair processes in which the cellular redox status plays a crucial role...
  5. ncbi Gated access to the pore of a voltage-dependent K+ channel
    Y Liu
    Department of Neurobiology, Harvard Medical School and Massachusetts General Hospital, Boston 02114, USA
    Neuron 19:175-84. 1997
    ..The results suggest that these channels open and close by the movement of an intracellular gate, distinct from the selectivity filter, that regulates access to the pore...
  6. pmc Microarray-based analysis of cadmium-responsive microRNAs in rice (Oryza sativa)
    Yanfei Ding
    State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou 310029, China
    J Exp Bot 62:3563-73. 2011
    ..Plant miRNAs have been implicated in developmental processes and adaptations to environmental stresses. Cadmium (Cd) is a non-essential heavy metal that is highly toxic to plants...
  7. doi Mitochondria, reactive oxygen species and cadmium toxicity in the kidney
    Glenda Gobe
    Centre for Kidney Disease Research, University of Queensland School of Medicine, Princess Alexandra Hospital, Woolloongabba, Brisbane 4102, Australia
    Toxicol Lett 198:49-55. 2010
    The heavy metal cadmium accumulates in kidney cells, particularly those of the proximal tubular epithelium, and the damage this causes is associated with development of chronic kidney disease...
  8. pmc Calcium signaling is involved in cadmium-induced neuronal apoptosis via induction of reactive oxygen species and activation of MAPK/mTOR network
    Baoshan Xu
    Department of Biochemistry and Molecular Biology, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
    PLoS ONE 6:e19052. 2011
    b>Cadmium (Cd), a toxic environmental contaminant, induces oxidative stress, leading to neurodegenerative disorders...
  9. doi Molecular mechanisms of metal hyperaccumulation in plants
    Nathalie Verbruggen
    Universite Libre de Bruxelles, B 1050 Brussels, Belgium
    New Phytol 181:759-76. 2009
    ..This review presents key aspects of our current understanding of plant metal – in particular cadmium (Cd),nickel (Ni) and zinc (Zn) – hyperaccumulation.
  10. pmc Metallothionein protection of cadmium toxicity
    Curtis D Klaassen
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Toxicol Appl Pharmacol 238:215-20. 2009
    The discovery of the cadmium (Cd)-binding protein from horse kidney in 1957 marked the birth of research on this low-molecular weight, cysteine-rich protein called metallothionein (MT) in Cd toxicology...
  11. pmc Cadmium, environmental exposure, and health outcomes
    Soisungwan Satarug
    Department of Pathology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202, USA
    Environ Health Perspect 118:182-90. 2010
    We provide an update of the issues surrounding health risk assessment of exposure to cadmium in food.
  12. pmc Cadmium exposure and cancer mortality in the Third National Health and Nutrition Examination Survey cohort
    Scott V Adams
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Occup Environ Med 69:153-6. 2012
    ..National Health and Nutrition Examination Survey (NHANES III) cohort to investigate the relationship between cadmium exposure and cancer mortality, and the specific cancers associated with cadmium exposure, in the general ..
  13. doi Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals
    Jean Marc Moulis
    Laboratoire de Chimie et Biologie des Metaux, CEA Grenoble, DSV, iRTSV, 17 rue des Martyrs, Grenoble Cedex 9, France
    Biometals 23:877-96. 2010
    The widespread occurrence of cadmium in the environment continues to pose a threat to human health despite attempts at limiting its technological uses...
  14. ncbi Effects of long-term low-dose cadmium exposure on genomic DNA methylation in human embryo lung fibroblast cells
    Gaofeng Jiang
    Faculty of Preventive Medicine, Medical College, Wuhan University of Science and Technology, Huangjiahu Campus, Wuhan 430065, Hubei Province, People s Republic of China
    Toxicology 244:49-55. 2008
    b>Cadmium is a toxic transition metal of continuing occupational and environmental concern. As a well-recognized human carcinogen, its carcinogenic mechanisms are still poorly understood...
  15. pmc Maternal cadmium exposure during pregnancy and size at birth: a prospective cohort study
    Maria Kippler
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Environ Health Perspect 120:284-9. 2012
    b>Cadmium (Cd) is an embryotoxic and teratogenic metal in a variety of animal species, but data from humans are limited.
  16. doi Dietary cadmium exposure and risk of postmenopausal breast cancer: a population-based prospective cohort study
    Bettina Julin
    Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Cancer Res 72:1459-66. 2012
    The ubiquitous food contaminant cadmium has features of an estrogen mimetic that may promote the development of estrogen-dependent malignancies, such as breast cancer...
  17. pmc Regulatory networks of cadmium stress in plants
    Giovanni DalCorso
    Dipartimento di Biotecnologie, Universita degli Studi di Verona, Verona, Italy
    Plant Signal Behav 5:663-7. 2010
    During their life, plants have to cope with a variety of abiotic stresses. Cadmium is highly toxic to plants, water soluble and therefore promptly adsorbed in tissues and its presence greatly influences the entire plant metabolism...
  18. doi Catch me if you can! Novel aspects of cadmium transport in mammalian cells
    Frank Thevenod
    Department of Physiology and Pathophysiology, University of Witten Herdecke, Stockumer Str 12, Witten, Germany
    Biometals 23:857-75. 2010
    b>Cadmium (Cd(2+)) is a nonessential divalent metal ion that causes toxicity in multiple organs in humans. In order for toxicity to occur Cd(2+) must first enter cells by utilizing transport pathways for essential metals...
  19. pmc Expression of arabidopsis CAX2 in tobacco. Altered metal accumulation and increased manganese tolerance
    K D Hirschi
    Baylor College of Medicine, Plant Physiology Group, United States Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Houston, Texas 77030, USA
    Plant Physiol 124:125-33. 2000
    ..These results suggest that CAX2 has a broad substrate range and modulation of this transporter may be an important component of future strategies to improve plant ion tolerance...
  20. ncbi Cadmium carcinogenesis
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Triangle Park, NC 27706, USA
    Mutat Res 533:107-20. 2003
    b>Cadmium is a heavy metal of considerable environmental and occupational concern. Cadmium compounds are classified as human carcinogens by several regulatory agencies...
  21. doi Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4
    Marc Hanikenne
    Max Planck Institute of Molecular Plant Physiology, D 14476 Potsdam, Germany
    Nature 453:391-5. 2008
    ..A. halleri naturally accumulates and tolerates leaf concentrations as high as 2.2% zinc and 0.28% cadmium in dry biomass. On the basis of transcriptomics studies, metal hyperaccumulation in A...
  22. doi Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5
    Long Chen
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
    Free Radic Biol Med 45:1035-44. 2008
    b>Cadmium (Cd), a highly toxic environmental pollutant, induces neurodegenerative diseases...
  23. pmc Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase
    Lamia Benbrahim-Tallaa
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 115:1454-9. 2007
    ..The typical pattern appears to involve reduced expression of maintenance DNA methyltransferase, DNMT1, inducing genomic hypomethylation, whereas increased expression of de novo DNMT3a or 3b causes gene-specific hypermethylation...
  24. ncbi Molecular and cellular mechanisms of cadmium carcinogenesis
    Michael Waisberg
    Department of Land Resource Science, University of Guelph, Guelph, Ont, Canada
    Toxicology 192:95-117. 2003
    b>Cadmium is a heavy metal, which is widely used in industry, affecting human health through occupational and environmental exposure...
  25. doi Transport pathways for cadmium in the intestine and kidney proximal tubule: focus on the interaction with essential metals
    David A Vesey
    Department of Nephrology, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Brisbane, Queensland 4102, Australia
    Toxicol Lett 198:13-9. 2010
    b>Cadmium (Cd) is a toxic metal with a propensity to accumulate in the proximal tubules cells (PTC) of the kidney where it can lead to tubular dysfunction and eventually renal failure...
  26. doi Burden of cadmium in early childhood: longitudinal assessment of urinary cadmium in rural Bangladesh
    Maria Kippler
    Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE 17177 Stockholm, Sweden
    Toxicol Lett 198:20-5. 2010
    Chronic cadmium exposure is associated with many adverse health effects in adults, but little is known about the scenario early in life...
  27. pmc Cadmium exposure and neurodevelopmental outcomes in U.S. children
    Timothy Ciesielski
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 120:758-63. 2012
    Low-level environmental cadmium exposure in children may be associated with adverse neurodevelopmental outcomes.
  28. doi Accumulation of cadmium in human placenta interacts with the transport of micronutrients to the fetus
    Maria Kippler
    Institute of Environmental Medicine, Division of Metals and Health, Karolinska Institutet, Stockholm, Sweden
    Toxicol Lett 192:162-8. 2010
    b>Cadmium (Cd) is a widespread, highly toxic environmental pollutant known to accumulate in human placenta...
  29. doi Mechanisms to cope with arsenic or cadmium excess in plants
    Nathalie Verbruggen
    Laboratoire de Physiologie et de Génétique Moléculaire des Plantes, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, Brussels, Belgium
    Curr Opin Plant Biol 12:364-72. 2009
    The metalloid arsenic and the heavy metal cadmium have no demonstrated biological function in plants. Both elements are highly toxic and of major concern with respect to their accumulation in soils, in the food-chain or in drinking water...
  30. ncbi Cadmium-free CuInS2/ZnS quantum dots for sentinel lymph node imaging with reduced toxicity
    Thomas Pons
    Laboratoire Physique et Etude des Materiaux, CNRS UPR0005, ESPCI, 10 rue Vauquelin, 75005 Paris, France
    ACS Nano 4:2531-8. 2010
    ....
  31. doi Sublethal cadmium intoxication in Arabidopsis thaliana impacts translation at multiple levels
    R Sormani
    Aix Marseille Universite, Laboratoire de Genetique et Biophysique des Plantes, F 13009 Marseille, France
    Plant Cell Physiol 52:436-47. 2011
    ..regulation during heavy metal poisoning, Arabidopsis thaliana cell cultures were submitted to sublethal cadmium stress...
  32. pmc Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis
    Timothy P Dalton
    Department of Environmental Health and the Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Proc Natl Acad Sci U S A 102:3401-6. 2005
    Testicular necrosis is a sensitive endpoint for cadmium (Cd(2+), Cd) toxicity across all species tested. Resistance to Cd-induced testicular damage is a recessive trait assigned to the Cdm locus on mouse chromosome 3...
  33. pmc Tubular and glomerular kidney effects in Swedish women with low environmental cadmium exposure
    Agneta Akesson
    Institute of Environmental Medicine, Division of Metals and Health, Karolinska Institutet, Stockholm, Sweden
    Environ Health Perspect 113:1627-31. 2005
    b>Cadmium is a well-known nephrotoxic agent in food and tobacco, but the exposure level that is critical for kidney effects in the general population is not defined...
  34. pmc Cadmium levels in urine and mortality among U.S. adults
    Andy Menke
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Environ Health Perspect 117:190-6. 2009
    b>Cadmium exposure has been associated with increased all-cause, cancer, and cardiovascular disease mortality...
  35. doi Cadmium and mitochondria
    Giuseppe Cannino
    Dipartimento di Biologia Cellulare e dello Sviluppo A Monroy, University of Palermo, Italy
    Mitochondrion 9:377-84. 2009
    The heavy metal cadmium (Cd) a pollutant associated with several modern industrial processes, is absorbed in significant quantities from cigarette smoke, water, food and air contaminations...
  36. pmc Cadmium exposure and hypertension in the 1999-2004 National Health and Nutrition Examination Survey (NHANES)
    Maria Tellez-Plaza
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe St, Rm W7033B, Baltimore, MD 21205, USA
    Environ Health Perspect 116:51-6. 2008
    b>Cadmium induces hypertension in animal models. Epidemiologic studies of cadmium exposure and hypertension, however, have been inconsistent.
  37. ncbi Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium
    Daniel Stewart
    Department of Molecular Genetics, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    J Biol Chem 278:2396-402. 2003
    ..b>Cadmium did not significantly affect the steady-state level of Nrf2 mRNA or the initial rate of Nrf2 protein synthesis ..
  38. pmc Cadmium is a mutagen that acts by inhibiting mismatch repair
    Yong Hwan Jin
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Nat Genet 34:326-9. 2003
    ..We found that chronic exposure of yeast to environmentally relevant concentrations of cadmium, a known human carcinogen, can result in extreme hypermutability...
  39. doi Status of toxic metals in biological samples of diabetic mothers and their neonates
    Nida Fatima Kolachi
    Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro 76080, Pakistan
    Biol Trace Elem Res 143:196-212. 2011
    ..The aim of present study was to compare the status of trace toxic elements, arsenic (As), cadmium (Cd), and lead (Pb) in biological samples (whole blood, urine and scalp hair) of insulin-dependent diabetic ..
  40. pmc Cadmium regulates the expression of the CFTR chloride channel in human airway epithelial cells
    Jessica Rennolds
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Toxicol Sci 116:349-58. 2010
    b>Cadmium is a toxic heavy metal ranked seventh on the Priority List of Hazardous Substances. As a byproduct of smelters, cadmium is a prevalent environmental contaminant...
  41. ncbi Urinary cadmium, impaired fasting glucose, and diabetes in the NHANES III
    Gary G Schwartz
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Diabetes Care 26:468-70. 2003
    Increasing rates of type 2 diabetes worldwide suggest that diabetes may be caused by environmental toxins. Cadmium is a widespread environmental pollutant that accumulates in the pancreas and exerts diabetogenic effects in animals...
  42. doi Multiple roles of cadmium in cell death and survival
    Douglas M Templeton
    University of Toronto, Canada
    Chem Biol Interact 188:267-75. 2010
    b>Cadmium is a toxic metal with no known biological function. It is increasingly important as an environmental hazard to both humans and wildlife, and it exemplifies the double edged nature of many toxic substances...
  43. pmc CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal cell death
    Sujuan Chen
    College of Life Sciences, Nanjing Normal University, Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, Nanjing, China
    J Neurochem 119:1108-18. 2011
    b>Cadmium (Cd), a toxic environmental contaminant, induces neurodegenerative diseases...
  44. ncbi Metal-induced apoptosis: mechanisms
    Marisa D Pulido
    Department of Medical Pharmacology and Toxicology, College of Medicine, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
    Mutat Res 533:227-41. 2003
    ..our current understanding of the apoptotic pathways that are initiated by metals, mainly established (arsenic, cadmium, chromium, nickel, beryllium) and possible (lead, antimony, cobalt) human carcinogens...
  45. pmc Cadmium exposure in pregnancy and lactation in relation to iron status
    Agneta Akesson
    Institute of Environmental Medicine, Division of Metals and Health, Karolinska Institutet, Stockholm, Sweden
    Am J Public Health 92:284-7. 2002
    The purpose of this study was to determine the impact of iron status on cadmium dose among pregnant women.
  46. pmc Reduction in cadmium exposure in the United States population, 1988-2008: the contribution of declining smoking rates
    Maria Tellez-Plaza
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room W7513D, Baltimore, MD 21205 USA
    Environ Health Perspect 120:204-9. 2012
    ..policies such as tobacco control, air pollution reduction, and hazardous waste remediation may have reduced cadmium exposure among U.S. adults...
  47. doi Microsporidia parasites disrupt the responses to cadmium exposure in a gammarid
    Eric Gismondi
    Laboratoire des Interactions Ecotoxicologie Biodiversité Ecosystèmes LIEBE, Universite Paul Verlaine Metz, CNRS UMR 7146, Campus Bridoux, Avenue du général Delestraint, 57070 Metz, France
    Environ Pollut 160:17-23. 2012
    ..the effect of microsporidian infections on energy reserves and defence capacities of Gammarus roeseli under cadmium stress. Only females were infected by two microsporidia parasites: Dictyocoela roeselum or Dictyocoela muelleri...
  48. doi Cadmium interacts with the transport of essential micronutrients in the mammary gland - a study in rural Bangladeshi women
    Maria Kippler
    Division of Metals and Health, Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE 171 77 Stockholm, Sweden
    Toxicology 257:64-9. 2009
    Although the concentrations of the toxic metal cadmium in breast milk are generally low (< 1 microg/L), experimental studies indicated neurobehavioral and endocrine effects in the suckling offspring...
  49. pmc Environmental cadmium and breast cancer risk
    Carolyn M Gallagher
    Doctoral Program in Population Health and Clinical Outcomes Research, Stony Brook University, Stony Brook, NY 11794, USA
    Aging (Albany NY) 2:804-14. 2010
    Breast cancer is the most prevalent women's cancer, with an age-adjusted incidence of 122.9 per 100,000 US women. Cadmium, a ubiquitous carcinogenic pollutant with multiple biological effects, has been reported to be associated with ..
  50. doi Cadmium as a transcriptional modulator in human cells
    Claudio Luparello
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, Palermo, Italy
    Crit Rev Toxicol 41:75-82. 2011
    b>Cadmium (Cd) is an underground mineral widely used in the steel industry, in plastics, and as a component of batteries...
  51. pmc Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance
    David G Mendoza-Cózatl
    Division of Biological Sciences, Cell and Developmental Biology Section, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:40416-26. 2010
    ..Abc2 expression restores phytochelatin accumulation into vacuoles and suppresses the cadmium sensitivity of the abc quintuple mutant...
  52. ncbi Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells. Role of p38 kinase and Nrf2 transcription factor
    J Alam
    Department of Molecular Genetics, Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121, USA
    J Biol Chem 275:27694-702. 2000
    ..SB203580, an inhibitor of p38, diminishes cadmium-stimulated pE1-luc expression and HO-1 mRNA levels by up to 70-80%...
  53. doi Nrf2 activation prevents cadmium-induced acute liver injury
    Kai C Wu
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Toxicol Appl Pharmacol 263:14-20. 2012
    Oxidative stress plays an important role in cadmium-induced liver injury. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that up-regulates cytoprotective genes in response to oxidative stress...
  54. ncbi Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges
    Sarah M Webster
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 428:864-8. 2004
    ..A narrower opening of the bundle crossing in Shaker K+ channels may help to explain why Shaker has an approximately tenfold lower conductance than its bacterial relatives...
  55. pmc Renal and neurologic effects of cadmium, lead, mercury, and arsenic in children: evidence of early effects and multiple interactions at environmental exposure levels
    Claire de Burbure
    Unit of Industrial Toxicology and Occupational Medicine, Faculty of Medicine, Catholic University of Louvain, Clos Chapelle aux Champs 30, B 1200 Brussels, Belgium
    Environ Health Perspect 114:584-90. 2006
    Lead, cadmium, mercury, and arsenic are common environmental pollutants in industrialized countries, but their combined impact on children's health is little known...
  56. ncbi Tight steric closure at the intracellular activation gate of a voltage-gated K(+) channel
    D del Camino
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 32:649-56. 2001
    ..Either these Kv channels have a broader inner entrance than seen in the KcsA crystal, even in the closed state, or the region is highly flexible (but nevertheless remains very securely closed nearby)...
  57. doi Cadmium and cellular signaling cascades: to be or not to be?
    Frank Thevenod
    Department of Physiology and Pathophysiology, University of Witten Herdecke, Witten, Germany
    Toxicol Appl Pharmacol 238:221-39. 2009
    The cellular effects of the toxic metal cadmium (Cd) are manifold. A large proportion of the cellular reactions affected by ionic Cd(2+) are mediated by cellular signaling cascades...
  58. doi Interpreting NHANES biomonitoring data, cadmium
    Patricia Ruiz
    Agency for Toxic Substances and Disease Registry, Atlanta, GA 30333, USA
    Toxicol Lett 198:44-8. 2010
    b>Cadmium (Cd) occurs naturally in the environment and the general population's exposure to it is predominantly through diet...
  59. doi Root responses to cadmium in the rhizosphere: a review
    Alexander Lux
    Department of Plant Physiology, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina B2, 842 15 Bratislava, Slovakia
    J Exp Bot 62:21-37. 2011
    This article reviews the responses of plant roots to elevated rhizosphere cadmium (Cd) concentrations. Cadmium enters plants from the soil solution...
  60. pmc Nitric oxide is involved in cadmium-induced programmed cell death in Arabidopsis suspension cultures
    Roberto De Michele
    Dipartimento di Biologia, Universita degli Studi di Padova, I 35131 Padova, Italy
    Plant Physiol 150:217-28. 2009
    Exposure to cadmium (Cd(2+)) can result in cell death, but the molecular mechanisms of Cd(2+) cytotoxicity in plants are not fully understood...
  61. doi Cadmium-induced autophagy and apoptosis are mediated by a calcium signaling pathway
    S H Wang
    Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan, ROC
    Cell Mol Life Sci 65:3640-52. 2008
    The cytotoxicity of cadmium (Cd) induced autophagy and apoptosis in MES-13 cells was determined by flow cytometry. Autophagy was also assessed by formation of autophagosomes and processing of LC3...
  62. pmc Cadmium triggers an integrated reprogramming of the metabolism of Synechocystis PCC6803, under the control of the Slr1738 regulator
    Laetitia Houot
    Commissariat a l Energie Atomique, Institut de Biologie et Tecnologies de Saclay, Service de Biologie Intégrative et Génétique Moléculaire, CEA Saclay F 91191 Gif sur Yvette CEDEX, France
    BMC Genomics 8:350. 2007
    b>Cadmium is a persistent pollutant that threatens most biological organisms, including cyanobacteria that support a large part of the biosphere...
  63. pmc Blood cadmium and lead and chronic kidney disease in US adults: a joint analysis
    Ana Navas-Acien
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Am J Epidemiol 170:1156-64. 2009
    Environmental cadmium and lead exposures are widespread, and both metals are nephrotoxic at high exposure levels...
  64. pmc Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity
    Yuxia Cui
    Nicholas School of the Environment and Earth Sciences, Duke University, Durham, NC 27708, USA
    Genome Biol 8:R122. 2007
    Exposure to cadmium is associated with a variety of human diseases. At low concentrations, cadmium activates the transcription of stress-responsive genes, which can prevent or repair the adverse effects caused by this metal.
  65. ncbi Effects of cadmium and zinc on plasma levels of growth hormone, insulin-like growth factor I, and insulin-like growth factor-binding protein 3
    Sebahat Turgut
    Department of Physiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey
    Biol Trace Elem Res 108:197-204. 2005
    Humans are constantly exposed to cadmium (Cd) as a result of the increase in air pollution and cigaret use...
  66. ncbi Environmental tobacco smoke (ETS) exposure in children with asthma-relation between lead and cadmium, and cotinine concentrations in urine
    Stefan Willers
    Unit of Preventive Medicine, Heart and Lung Center, Lund University Hospital, SE 221 85 Lund, Sweden
    Respir Med 99:1521-7. 2005
    ..The corresponding concentrations of the heavy metals cadmium and lead in dust and urine (U-Cd; U-Pb) were determined in the same samples...
  67. ncbi Cadmium concentration in maternal and cord blood and infant birth weight: a study on healthy non-smoking women
    Carmelo D Salpietro
    Operative Unit of Pediatric Genetics and Immunology, School of Medicine, University of Messina, Italy
    J Perinat Med 30:395-9. 2002
    The aim of our study was to measure, at delivery, maternal and cord blood cadmium levels (by means of atomic absorption spectrometry) in 45 healthy non-smoking pregnant women exposed to a low cadmium challenge, and to evaluate the ..
  68. ncbi The role of mercury and cadmium heavy metals in vascular disease, hypertension, coronary heart disease, and myocardial infarction
    Mark C Houston
    Vanderbilt University School of Medicine, USA
    Altern Ther Health Med 13:S128-33. 2007
    Mercury, cadmium, and other heavy metals have a high affinity for sulfhydryl (-SH) groups, inactivating numerous enzymatic reactions, amino acids, and sulfur-containing antioxidants (NAC, ALA, GSH), with subsequent decreased oxidant ..
  69. ncbi Transgenic Indian mustard (Brassica juncea) plants expressing an Arabidopsis phytochelatin synthase (AtPCS1) exhibit enhanced As and Cd tolerance
    Ksenija Gasic
    Department of Natural Resources and Environmental Sciences, University of Illinois at Urbana Champaign, 310 ERML, 1201 W Gregory Dr, Urbana, IL 61801, USA
    Plant Mol Biol 64:361-9. 2007
    ..mustard, and transgenic pcs lines have been compared with wild-type plants for tolerance to and accumulation of cadmium (Cd) and arsenic (As)...
  70. ncbi Redox regulates COX-2 upregulation and cell death in the neuronal response to cadmium
    Patricia Rockwell
    Department of Biological Sciences, Hunter College of the City University of New York, New York, NY 10021, USA
    Cell Signal 16:343-53. 2004
    We reported previously that cadmium, an oxidative stressor, induced cyclooxygenase-2 (COX-2) upregulation in mouse neuronal cells that culminated in cell death...
  71. ncbi Localization of S-nitrosoglutathione and expression of S-nitrosoglutathione reductase in pea plants under cadmium stress
    Juan B Barroso
    Grupo de Señalización Molecular y Sistemas Antioxidantes en Plantas, Unidad Asociada al CSIC Estación Experimental del Zaidín, Área de Bioquímica y Biología Molecular, Universidad de Jaen, E 23071 Jaén, Spain
    J Exp Bot 57:1785-93. 2006
    ..scanning microscopy and HPLC, respectively, showed a marked decrease of both compounds in plants treated with cadmium. The analysis of the S-nitrosoglutathione reductase (GSNOR) activity and its transcript expression in leaves ..
  72. ncbi Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation
    Masufumi Takiguchi
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Exp Cell Res 286:355-65. 2003
    b>Cadmium is a human carcinogen that likely acts via epigenetic mechanisms...
  73. doi Role of oxidative stress, apoptosis, and intracellular homeostasis in primary cultures of rat proximal tubular cells exposed to cadmium
    Lin Wang
    College of Veterinary Medicine, Yangzhou University, 12 East Wenhui Road, Yangzhou, 225009, People s Republic of China
    Biol Trace Elem Res 127:53-68. 2009
    b>Cadmium (Cd) is a known nephrotoxic element. In this study, the primary cultures of rat proximal tubular (rPT) cells were treated with low doses of cadmium acetate (2.5 and 5 microM) to investigate its cytotoxic mechanism...
  74. pmc Bioavailability of cadmium in inexpensive jewelry
    Jeffrey D Weidenhamer
    Department of Chemistry, Geology and Physics, Ashland University, Ashland, Ohio 44805, USA
    Environ Health Perspect 119:1029-33. 2011
    ..We evaluated the bioavailability of Cd in 86 components of 57 jewelry items found to contain high levels of Cd (> 10,000 ppm) by X-ray fluorescence (XRF), using extractions that simulate mouthing or swallowing of jewelry items...
  75. pmc Tracing cadmium from culture to spikelet: noninvasive imaging and quantitative characterization of absorption, transport, and accumulation of cadmium in an intact rice plant
    Shu Fujimaki
    Plant Positron Imaging Group, Quantum Beam Science Directorate, Japan Atomic Energy Agency, Takasaki, Gunma 370 1292, Japan
    Plant Physiol 152:1796-806. 2010
    We characterized the absorption and short-term translocation of cadmium (Cd) in rice (Oryza sativa 'Nipponbare') quantitatively using serial images observed with a positron-emitting tracer imaging system...
  76. doi OsHMA3, a P1B-type of ATPase affects root-to-shoot cadmium translocation in rice by mediating efflux into vacuoles
    Hidenori Miyadate
    Department of Biological Production, Faculty of Bioresource Sciences, Akita Prefectural University, Shimoshinjyo Nakano, Akita, Japan
    New Phytol 189:190-9. 2011
    The cadmium (Cd) over-accumulating rice (Oryza sativa) cv Cho-Ko-Koku was previously shown to have an enhanced rate of root-to-shoot Cd translocation. This trait is controlled by a single recessive allele located at qCdT7...
  77. doi Fetal growth restriction is related to placental levels of cadmium, lead and arsenic but not with antioxidant activities
    Miguel N Llanos
    Laboratory of Nutrition and Metabolic Regulation, Institute of Nutrition and Food Technology INTA, University of Chile, Macul 5540, Casilla 138 11, Santiago, Chile
    Reprod Toxicol 27:88-92. 2009
    ..mercury, selenium and arsenic were measured by Instrumental Neutron Activation Analysis (INAA), and iron, copper, cadmium and lead by Atomic Absorption Spectrometry (AAS)...
  78. ncbi Effects of soluble cadmium salts versus CdSe quantum dots on the growth of planktonic Pseudomonas aeruginosa
    John H Priester
    Donald Bren School of Environmental Science and Management, Department of Chemistry and Biochemistry, Earth Sciences, and Materials Research Laboratory, University of California, Santa Barbara, California 93106, USA
    Environ Sci Technol 43:2589-94. 2009
    ..ENMs, such as CdSe quantum dots (QDs), are toxic due to the release of dissolved heavy metals, but the effects of cadmium ions versus intact QDs are mostly unknown...
  79. doi Acute metal stress in Populus tremula x P. alba (717-1B4 genotype): leaf and cambial proteome changes induced by cadmium 2+
    Thomas C Durand
    CRP Gabriel Lippmann, Department Environment and Agro Biotechnologies, Belvaux, GD, Luxembourg
    Proteomics 10:349-68. 2010
    ..alba (717-1B4 genotype) were analyzed after 61 days of exposure to cadmium (Cd) 360 mg/kg soil dry weight in pot-soil cultures...
  80. ncbi Quantitative changes in protein expression of cadmium-exposed poplar plants
    Pol Kieffer
    Department Environment and Agrobiotechnologies, Centre de Recherche Public Gabriel Lippmann, Belvaux, Luxembourg
    Proteomics 8:2514-30. 2008
    b>Cadmium (Cd) pollution is a worldwide major concern having, among others, deleterious effects on plants...
  81. doi Heavy metal-regulated new microRNAs from rice
    Si Qi Huang
    Department of Biochemistry and Molecular Biology, College of Life Science, Nanjing Agricultural University, Nanjing, China
    J Inorg Biochem 103:282-7. 2009
    ..novel miRNAs, we constructed a library of small RNAs from rice seedlings that were exposed to toxic levels of cadmium (Cd(2+)). Sequencing of the library and subsequent analysis revealed 19 new miRNAs representing six families...
  82. doi Lung cancer risk associated with occupational exposure to nickel, chromium VI, and cadmium in two population-based case-control studies in Montreal
    Rachelle Beveridge
    Departement de Medecine sociale et preventive, Universite de Montreal, Montreal, QC, Canada
    Am J Ind Med 53:476-85. 2010
    Nickel, chromium VI, and cadmium have been identified as lung carcinogens in highly exposed cohorts...
  83. doi National estimates of blood lead, cadmium, and mercury levels in the Korean general adult population
    Nam Soo Kim
    Institute of Environmental and Occupational Medicine, College of Medicine, Soonchunhyang University, 646 Eupnae ri, Shinchang myun, Asan, Choongnam, 336 745, Korea
    Int Arch Occup Environ Health 84:53-63. 2011
    To assess the extent of exposure to lead, cadmium, and mercury in the Korean general adult population using a representative sample.
  84. doi Mechanisms in cadmium-induced carcinogenicity: recent insights
    Andrea Hartwig
    Institut für Lebensmitteltechnologie und Lebensmittelchemie, Fachgebiet Lebensmittelchemie und Toxikologie, Technische Universitat Berlin, Berlin, Germany
    Biometals 23:951-60. 2010
    b>Cadmium is an environmental pollutant,with relevant exposures at workplaces and in the general population...
  85. pmc Induction of Hsp22 (HspB8) by estrogen and the metalloestrogen cadmium in estrogen receptor-positive breast cancer cells
    Xiankui Sun
    University of Michigan Medical School, Department of Cell and Developmental Biology, 3065 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    Cell Stress Chaperones 12:307-19. 2007
    ..b>Cadmium (Cd) is an environmental pollutant with estrogenic properties (metalloestrogen) that has been implicated in ..
  86. ncbi Chronic exposure to cadmium and arsenic strongly influences concentrations of 8-oxo-7,8-dihydro-2'-deoxyguanosine in urine
    Karin S Engström
    Section of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, 221 85 Lund, Sweden
    Free Radic Biol Med 48:1211-7. 2010
    Exposure to arsenic (As), cadmium (Cd), and lead (Pb) may generate oxidative stress, which can be assessed by 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in urine, a sensitive marker of oxidatively damaged DNA...
  87. pmc AtOSA1, a member of the Abc1-like family, as a new factor in cadmium and oxidative stress response
    Michal Jasinski
    University of Zurich, Institute of Plant Biology, 8008 Zurich, Switzerland
    Plant Physiol 147:719-31. 2008
    ..Our data suggest that the chloroplast AtOSA1 protein is a new factor playing a role in the balance of oxidative stress...
  88. ncbi Endoplasmic reticulum stress and alteration in calcium homeostasis are involved in cadmium-induced apoptosis
    Marta Biagioli
    Laboratory of Cellular and Development Biology, Department of Biology, University of Pisa, Italy
    Cell Calcium 43:184-95. 2008
    b>Cadmium, a toxic environmental contaminant, exerts adverse effects on different cellular pathways such as cell proliferation, DNA damage and apoptosis...
  89. doi Cadmium exposure in the population: from health risks to strategies of prevention
    Tim S Nawrot
    Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium
    Biometals 23:769-82. 2010
    We focus on the recent evidence that elucidates our understanding about the effects of cadmium (Cd) on human health and their prevention...
  90. pmc A major quantitative trait locus for cadmium tolerance in Arabidopsis halleri colocalizes with HMA4, a gene encoding a heavy metal ATPase
    Mikael Courbot
    Laboratoire de Physiologie et de Génétique Moléculaire des Plantes, Universite Libre de Bruxelles, B 1050 Brussels, Belgium
    Plant Physiol 144:1052-65. 2007
    b>Cadmium (Cd) tolerance seems to be a constitutive species-level trait in Arabidopsis halleri sp. halleri. Therefore, an interspecific cross was made between A...
  91. ncbi The vascular endothelium as a target of cadmium toxicity
    Walter C Prozialeck
    Department of Pharmacology, Midwestern University, 555 31st Street, Downers Grove, IL 60515, United States
    Life Sci 79:1493-506. 2006
    b>Cadmium (Cd) is an important industrial and environmental pollutant that can produce a wide variety of adverse effects in humans and animals...
  92. pmc Cellular response of pea plants to cadmium toxicity: cross talk between reactive oxygen species, nitric oxide, and calcium
    María Rodríguez-Serrano
    Departamento de Bioquimica, Biologia Celular y Molecular de Plantas, Estacion Experimental del Zaidin, Consejo Superior de Investigaciones Cientificas, E 18008 Granada, Spain
    Plant Physiol 150:229-43. 2009
    b>Cadmium (Cd) toxicity has been widely studied in different plant species; however, the mechanism involved in its toxicity as well as the cell response against the metal have not been well established...
  93. ncbi Carbon monoxide alleviates cadmium-induced oxidative damage by modulating glutathione metabolism in the roots of Medicago sativa
    Yi Han
    College of Life Sciences, Co Laboratory of Nanjing Agricultural University and Carl Zeiss Far East, Nanjing Agricultural University, Nanjing 210095, PR China
    New Phytol 177:155-66. 2008
    Using pharmacological and biochemical approaches, the role of cadmium (Cd)-induced carbon monoxide (CO) release and the relationship between CO and oxidative stress conferred by Cd exposure in the root tissues of alfalfa (Medicago sativa)..
  94. ncbi A rapid and transient ROS generation by cadmium triggers apoptosis via caspase-dependent pathway in HepG2 cells and this is inhibited through N-acetylcysteine-mediated catalase upregulation
    Seon Hee Oh
    Research Center for Resistant Cells, College of Medicine, Chosun University, Seosuk dong, Dong Gu, Gwangju 501 759, South Korea
    Toxicol Appl Pharmacol 212:212-23. 2006
    Although reactive oxygen species (ROS) have been implicated in cadmium (Cd)-induced hepatotoxicity, the role of ROS in this pathway remains unclear...
  95. ncbi Cadmium-mediated oxidative stress in kidney proximal tubule cells induces degradation of Na+/K(+)-ATPase through proteasomal and endo-/lysosomal proteolytic pathways
    F Thevenod
    II Department of Physiology, University of Saarland, D 66421 Homburg, Germany
    FASEB J 13:1751-61. 1999
    The mechanisms of cadmium (Cd)-dependent nephrotoxicity were studied in a rat proximal tubule (PT) cell line...
  96. ncbi The transcription factor MTF-1 mediates metal regulation of the mouse ZnT1 gene
    S J Langmade
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Biol Chem 275:34803-9. 2000
    ..Zinc or cadmium treatment of cell lines rapidly (3 h) and dramatically (about 12-fold) induced ZnT1 mRNA levels...
  97. ncbi Toxic and essential elements in placentas of Swedish women
    K Osman
    Institute of Environmental Medicine, Division of Metals and Health, Karolinska Institutet, Stockholm, Sweden
    Clin Biochem 33:131-8. 2000
    ..To evaluate interactions between toxic and essential elements in the mother-fetus relationship and possible predictors of trace element concentrations in placenta and cord blood...
  98. pmc Investigating heavy-metal hyperaccumulation using Thlaspi caerulescens as a model system
    Matthew J Milner
    Robert W Holley Center for Agriculture and Health, USDA ARS, Cornell University, Ithaca, NY 14853, USA
    Ann Bot 102:3-13. 2008
    ..caerulescens, has been widely studied for its remarkable properties to tolerate toxic levels of zinc (Zn), cadmium (Cd) and sometimes nickel (Ni) in the soil, and accumulate these metals to very high levels in the shoot...
  99. ncbi Regulation of metallothionein gene expression by oxidative stress and metal ions
    G K Andrews
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City 66160 7421, USA
    Biochem Pharmacol 59:95-104. 2000
    ..Transcription of these genes is rapidly and dramatically up-regulated in response to zinc and cadmium, as well as in response to agents which cause oxidative stress and/or inflammation...
  100. pmc Cadmium-induced changes in antioxidative systems, hydrogen peroxide content, and differentiation in Scots pine roots
    A Schützendübel
    Forstbotanisches Institut, Abteilung I Forstbotanik und Baumphysiologie, Georg August Universitat Gottingen, Büsgenweg 2, 37077 Gottingen, Germany
    Plant Physiol 127:887-98. 2001
    ..This, in turn, may have triggered the developmental program leading to xylogenesis. In conclusion, Cd did not cause necrotic injury in root tips but appeared to expedite differentiation, thus leading to accelerated aging...
  101. doi Cadmium: toxic effects on the reproductive system and the embryo
    Jennifer Thompson
    School of Medicine and Medical Science, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
    Reprod Toxicol 25:304-15. 2008
    The heavy metal cadmium (Cd) is a pollutant associated with several modern industrial processes...

Research Grants95

  1. Lead, Cadmium,Arsenic, and cardiovascular risk in children
    Eliseo Guallar; Fiscal Year: 2009
    ..It is based upon a growing epidemiological literature, by us and others, indicating that exposure to lead, cadmium, or arsenic increases cardiovascular risk...
  2. Project 1: In vitro Studies: Correlate the physical and chemical characteristics
    David L Eaton; Fiscal Year: 2011
    ..and toxicity of Qdots and this has been primarily focused on their potential to degrade in vivo, thus releasing cadmium, selenium or other toxic metals [24, 29, 30]...
  3. Hazardous Waste Worker Training Program (HWWTP)
    JOHN DENNIS DEVLIN; Fiscal Year: 2011
    ..hazards include: electrocution, crushing from cave-ins during excavations, asbestos, mercury, arsenic, lead, cadmium and other heavy metals to name a few...
  4. MECHANISM OF LUMINAL ACIDIFICATION IN EPIDIDYMIS & VAS DEFERENS
    Sylvie Breton; Fiscal Year: 2002
    ..3) Effect of heavy metals on proton secretion: Exposure to lead, cadmium. manganese and mercury has been shown to reduce male reproductive capacity in a variety of species including ..
  5. MECHANISM OF LUMINAL ACIDIFICATION IN EPIDIDYMIS & VAS DEFERENS
    Sylvie Breton; Fiscal Year: 2001
    ..3) Effect of heavy metals on proton secretion: Exposure to lead, cadmium. manganese and mercury has been shown to reduce male reproductive capacity in a variety of species including ..
  6. Analyzer for Monitoring Personal Environmental Exposure to Fluids and Materials
    MATTHEW CUSACK; Fiscal Year: 2009
    ..Abnormal levels of bio-essential metals (iron, copper, and zinc) as well as toxic trace elements (mercury, lead, cadmium, and arsenic) are known to be associated with many health disorders such as cancer, cognitive impairment, and ..
  7. Metal Toxicant Effects on Small Heat-Shock Proteins in Kidney Podocytes
    William Smoyer; Fiscal Year: 2001
    The most abundant toxic metals in our environment include arsenic, cadmium, lead and mercury, and each of these metals is known to produce cellular injury to the kidney...
  8. Analyzer for Monitoring Personal Environmental Exposure to Fluids and Materials
    MATTHEW CUSACK; Fiscal Year: 2010
    ..Abnormal levels of bio-essential metals (iron, copper, and zinc) as well as toxic trace elements (mercury, lead, cadmium, and arsenic) are known to be associated with many health disorders such as cancer, cognitive impairment, and ..
  9. Lead, Cadmium,Arsenic, and cardiovascular risk in children
    Eliseo Guallar; Fiscal Year: 2011
    ..It is based upon a growing epidemiological literature, by us and others, indicating that exposure to lead, cadmium, or arsenic increases cardiovascular risk...
  10. Lead, Cadmium,Arsenic, and cardiovascular risk in children
    Eliseo Guallar; Fiscal Year: 2010
    ..It is based upon a growing epidemiological literature, by us and others, indicating that exposure to lead, cadmium, or arsenic increases cardiovascular risk...
  11. Divalent metal-ion transporter DMT1 and its role in intestinal metal-ion uptake
    Bryan Mackenzie; Fiscal Year: 2009
    ..Important for this proposal, iron deficiency is a serious risk factor for cadmium intoxication, suggesting that cadmium and iron share a common absorptive mechanism...
  12. Divalent metal-ion transporter DMT1 and its role in intestinal metal-ion uptake
    Bryan Mackenzie; Fiscal Year: 2010
    ..Important for this proposal, iron deficiency is a serious risk factor for cadmium intoxication, suggesting that cadmium and iron share a common absorptive mechanism...
  13. Divalent metal-ion transporter DMT1 and its role in intestinal metal-ion uptake
    Bryan Mackenzie; Fiscal Year: 2009
    ..Important for this proposal, iron deficiency is a serious risk factor for cadmium intoxication, suggesting that cadmium and iron share a common absorptive mechanism...
  14. EFFECT OF DIETARY FACTORS ON METALLOTHIONEIN LEVELS
    PHILIP WHANGER; Fiscal Year: 1980
    ..development in rats; (2) investigate the metabolism of radioactive MT (thionein) containing radioactive zinc, cadmium, mercury or copper; (3) determine the effects of stress on half-life of MT; (4) determine the influence of ..
  15. INCREASED TESTICULAR CD2+ & INFERTILITY WITH VARICOCELE
    Susan Benoff; Fiscal Year: 2004
    ..In preliminary studies, VAI patients' seminal plasma and testes biopsies contain significantly higher cadmium (Cd2+) than other infertile males, though blood levels were indistinguishable...
  16. Low-cost Large-area High-Sensitivity X-ray Panel Detector for Digital Mammography
    NEAL EUGENE HARTSOUGH; Fiscal Year: 2010
    ..By growing polycrystalline CZT (cadmium zinc telluride) films directly onto custom CMOS readouts, we will create large area panels with high resolution ..
  17. Epidemiological Research on Autism in Jamaica
    Mohammad H Rahbar; Fiscal Year: 2010
    ..and sex matched case-control study to investigate whether environmental exposures to mercury, lead, arsenic and cadmium play a role in autism...
  18. Epidemiological Research on Autism in Jamaica
    Mohammad Rahbar; Fiscal Year: 2009
    ..and sex matched case-control study to investigate whether environmental exposures to mercury, lead, arsenic and cadmium play a role in autism...
  19. TOXIC METALS--BIOLOGICAL/ENVIRONMENTAL IMPLICATIONS
    Joshua Hamilton; Fiscal Year: 1999
    ..provided to NIEHS by the EPA Office of Solid Waste and Emergency, contains eight metals: lead, chromium, arsenic, cadmium, zinc, copper, mercury, and nickel...
  20. TOXIC METALS--BIOLOGICAL/ENVIRONMENTAL IMPLICATIONS
    Joshua Hamilton; Fiscal Year: 1999
    ..provided to NIEHS by the EPA Office of Solid Waste and Emergency, contains eight metals: lead, chromium, arsenic, cadmium, zinc, copper, mercury, and nickel...
  21. New Optics for Trace Level Detection of Toxins in Environmental and Biological Sa
    ZEWU CHEN; Fiscal Year: 2010
    ..Two of the most difficult elements for XRF are cadmium (Cd) and antimony (Sb)...
  22. MECHANISMS OF TOXICITY IN TESTES
    Michael Welsh; Fiscal Year: 1993
    ..b>Cadmium or ethanol, both inducers of the stress or heat-shock response, result in failure of spermatid release in vivo...
  23. INHALED PARTICLE CHARACTERISTICS AND EARLY LUNG EFFECTS
    William Beckett; Fiscal Year: 2000
    ..shown an excess of COPD associated with dusty work environments, yet only a few substances (coal, silica, cadmium) causing COPD in the workplace have been characterized based on chemical composition and respirable particle size...
  24. INHALED PARTICLE CHARACTERISTICS AND EARLY LUNG EFFECTS
    William Beckett; Fiscal Year: 2001
    ..shown an excess of COPD associated with dusty work environments, yet only a few substances (coal, silica, cadmium) causing COPD in the workplace have been characterized based on chemical composition and respirable particle size...
  25. PROSPECTIVE NEUROEPIDEMIOLOGY OF ADULT LEAD EXPOSURE
    Philip Landrigan; Fiscal Year: 1992
    ..of exposure to lead will include whole blood lead levels as well as bone lead content as determined by 109 cadmium (Cd) X-ray fluorescence (XRF) spectrometry...
  26. INHALED PARTICLE CHARACTERISTICS AND EARLY LUNG EFFECTS
    William Beckett; Fiscal Year: 2002
    ..shown an excess of COPD associated with dusty work environments, yet only a few substances (coal, silica, cadmium) causing COPD in the workplace have been characterized based on chemical composition and respirable particle size...
  27. Role of Physico-chemical Properties in the Reprotoxicity of Inhaled Cd NP.
    JUDITH TERRY ZELIKOFF; Fiscal Year: 2010
    ..Most non-carbon NP contain one or more toxicologically-active metals, including cadmium (Cd)...
  28. SYNTHETIC ANALOGS FOR ZN, CD, AND HG-CONTAINING PROTEINS
    Stephen Koch; Fiscal Year: 1992
    The research plan is to define and develop the coordination chemistry of zinc, cadmium and mercury as a basis for understanding the biochemistry of proteins that contain these metals...
  29. Role of Physico-chemical Properties in the Reprotoxicity of Inhaled Cd NP.
    Judith Zelikoff; Fiscal Year: 2009
    ..Most non-carbon NP contain one or more toxicologically-active metals, including cadmium (Cd)...
  30. Chronic Cadmium Exposure Promotes Breast Cancer Progression
    Maggie C Louie; Fiscal Year: 2012
    ..development of hormone refractory breast cancer may involve endocrine disruptors, including heavy metals such as cadmium. Cadmium is an environmental contaminant that enters the body through the diet or cigarette smoke...
  31. Chronic Cadmium Exposure Promotes Breast Cancer Progression
    Maggie C Louie; Fiscal Year: 2010
    ..development of hormone refractory breast cancer may involve endocrine disruptors, including heavy metals such as cadmium. Cadmium is an environmental contaminant that enters the body through the diet or cigarette smoke...
  32. Chronic Cadmium Exposure Promotes Breast Cancer Progression
    Maggie C Louie; Fiscal Year: 2011
    ..development of hormone refractory breast cancer may involve endocrine disruptors, including heavy metals such as cadmium. Cadmium is an environmental contaminant that enters the body through the diet or cigarette smoke...
  33. Novel Chelators for Highly Efficient Removal of Toxic Heavy Metals in Humans
    Charles Timchalk; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Exposure to toxic metals like cadmium (Cd), lead (Pb), mercury (Hg), chromate (CrO42-), arsenite (As) (III), and arsenate (AsO43-) are known to induce various diseases that are detrimental to human ..
  34. Field-Deployable Monitor to Assess Personal Exposure to Multiple Heavy Metals
    BADAWI M DWEIK; Fiscal Year: 2010
    ..is to develop a portable, self-contained, easy-to-use monitor for simultaneous on-site measurement of arsenic, cadmium, manganese and lead metals from a single urine sample, in near real time, to assess personal exposure...
  35. Field-Deployable Monitor to Assess Personal Exposure to Multiple Heavy Metals
    BADAWI DWEIK; Fiscal Year: 2009
    ..is to develop a portable, self-contained, easy-to-use monitor for simultaneous on-site measurement of arsenic, cadmium, manganese and lead metals from a single urine sample, in near real time, to assess personal exposure...
  36. FUNCTIONAL ANALYSIS OF A LEAD/CADMIUM/ZINC ATPASE
    Bharati Mitra; Fiscal Year: 2007
    ..essential trace metals like copper, zinc, cobalt and nickel, and mediate resistance to toxic metals such as lead, cadmium and silver...
  37. FUNCTIONAL ANALYSIS OF A LEAD/CADMIUM/ZINC ATPASE
    Bharati Mitra; Fiscal Year: 2006
    ..essential trace metals like copper, zinc, cobalt and nickel, and mediate resistance to toxic metals such as lead, cadmium and silver...
  38. ENDOCRINE EFFECTS OF REPRODUCTIVE TOXINS IN FEMALE FISH
    Peter Thomas; Fiscal Year: 1990
    ..The actions of cadmium, lead, a polychlorinated biphenyl mixture (Aroclor 1254), an antiestrogen (clomiphene) and an estrogenic ..
  39. MODULATION OF CHOROID PLEXUS CHOLINE TRANSPORT BY METALS
    Alice Villalobos; Fiscal Year: 2002
    ..The objective of this proposal is to characterize modulation of choroid plexus choline transport by zinc and cadmium as a means to predict the potential for heavy metals to alter choline availability in the brain...
  40. MODULATION OF CHOROID PLEXUS CHOLINE TRANSPORT BY METALS
    Alice Villalobos; Fiscal Year: 2001
    ..The objective of this proposal is to characterize modulation of choroid plexus choline transport by zinc and cadmium as a means to predict the potential for heavy metals to alter choline availability in the brain...
  41. MODULATION OF CHOROID PLEXUS CHOLINE TRANSPORT BY METALS
    Alice Villalobos; Fiscal Year: 2000
    ..The objective of this proposal is to characterize modulation of choroid plexus choline transport by zinc and cadmium as a means to predict the potential for heavy metals to alter choline availability in the brain...
  42. FUNCTIONAL ANALYSIS OF A LEAD/CADMIUM/ZINC ATPASE
    Bharati Mitra; Fiscal Year: 2010
    ..essential trace metals like copper, zinc, cobalt and nickel, and mediate resistance to toxic metals such as lead, cadmium and silver...
  43. Catalytic DNA Biosensor for Toxic Metal Ions
    Yi Lu; Fiscal Year: 2009
    ..Cost-effective catalytic DNA biosensors for heavy metal ions such as lead(II), uranium(VI), mercury(II), and cadmium(II) will be developed...
  44. METAL CARCINOGEN-INDUCED MUTATIONS IN MAMMALIAN GENES
    EDWIN MURPHY; Fiscal Year: 1990
    ..g., compounds of nickel, chromium and cadmium) known to induce respiratory and bladder cancers as well as birth defects...
  45. TRANSPORT AND ACTIONS OF METAL IONS
    PATRICIA HINKLE; Fiscal Year: 1992
    ..is to elucidate the molecular mechanisms involved in the transport and toxic actions of heavy metals such as cadmium and lead...
  46. Mechanisms for Adverse Renal Effects from Lead Exposure
    Virginia Weaver; Fiscal Year: 2006
    ..We are investigating a broad set of causes of renal function decline, including lead and cadmium dose, blood pressure, diabetes, and age, in a longitudinal study of current and former Korean lead workers and ..
  47. BIOCHEMICAL AND PHARMACOLOGICAL INVESTIGATIONS
    KINFE REDDA; Fiscal Year: 1993
    ..2) Sequence Analysis of -Actinin Gene and Its Regulation by Thyroid Hormones; (3) Selenium Compounds and Cadmium Toxicity on Lungs; (4) Colchicine and Taxol Analogs as Probes of Tubulin; (5) Biologically Active Substances ..
  48. Molecular Mechanisms of Heavy Metal Detoxification
    JULIAN SCHROEDER; Fiscal Year: 2005
    Soils and waters with high levels of toxic heavy metals such as cadmium, arsenic, lead and mercury are detrimental to human and environmental health. These 4 metal(loid)s are among the Superfund's top 7 priority hazardous substances...
  49. CENTER FOR MEMBRANE TOXICITY STUDIES
    James Boyer; Fiscal Year: 2002
    ..Projects supported examine the mechanism of action of cadmium, cobalt, mercury, methylmercury and nickel on various membrane transport systems in tissues including hepatic, ..
  50. A SOCIAL NETWORK-BASED INTERVENTION TO REDUCE LEAD EXPOS
    Michelle Kegler; Fiscal Year: 2004
    ..The proposed research builds on previous work with these tribes, by expanding to address cadmium in addition to lead, and by adding a youth component...
  51. CENTER FOR MEMBRANE TOXICITY STUDIES
    James Boyer; Fiscal Year: 1999
    ..Projects supported examine the mechanism of action of cadmium, cobalt, mercury, methylmercury and nickel on various membrane transport systems in tissues including hepatic, ..
  52. CENTER FOR MEMBRANE TOXICITY STUDIES
    James Boyer; Fiscal Year: 2003
    ..Projects supported examine the mechanism of action of cadmium, cobalt, mercury, methylmercury and nickel on various membrane transport systems in tissues including hepatic, ..
  53. A SOCIAL NETWORK-BASED INTERVENTION TO REDUCE LEAD EXPOS
    Michelle Kegler; Fiscal Year: 2002
    ..The proposed research builds on previous work with these tribes, by expanding to address cadmium in addition to lead, and by adding a youth component...
  54. CENTER FOR MEMBRANE TOXICITY STUDIES
    James Boyer; Fiscal Year: 2002
    ..Projects supported examine the mechanism of action of cadmium, cobalt, mercury, methylmercury and nickel on various membrane transport systems in tissues including hepatic, ..
  55. A SOCIAL NETWORK-BASED INTERVENTION TO REDUCE LEAD EXPOS
    Michelle Kegler; Fiscal Year: 2001
    ..The proposed research builds on previous work with these tribes, by expanding to address cadmium in addition to lead, and by adding a youth component...
  56. CENTER FOR MEMBRANE TOXICITY STUDIES
    James Boyer; Fiscal Year: 2001
    ..Projects supported examine the mechanism of action of cadmium, cobalt, mercury, methylmercury and nickel on various membrane transport systems in tissues including hepatic, ..
  57. CENTER FOR MEMBRANE TOXICITY STUDIES
    James Boyer; Fiscal Year: 1999
    ..Projects supported examine the mechanism of action of cadmium, cobalt, mercury, methylmercury and nickel on various membrane transport systems in tissues including hepatic, ..
  58. CENTER FOR MEMBRANE TOXICITY STUDIES
    James Boyer; Fiscal Year: 2000
    ..Projects supported examine the mechanism of action of cadmium, cobalt, mercury, methylmercury and nickel on various membrane transport systems in tissues including hepatic, ..
  59. A SOCIAL NETWORK-BASED INTERVENTION TO REDUCE LEAD EXPOS
    Michelle Kegler; Fiscal Year: 2000
    ..The proposed research builds on previous work with these tribes, by expanding to address cadmium in addition to lead, and by adding a youth component...
  60. A SOCIAL NETWORK-BASED INTERVENTION TO REDUCE LEAD EXPOS
    Michelle Kegler; Fiscal Year: 2003
    ..The proposed research builds on previous work with these tribes, by expanding to address cadmium in addition to lead, and by adding a youth component...
  61. CENTER FOR MEMBRANE TOXICITY STUDIES
    James Boyer; Fiscal Year: 2000
    ..Projects supported examine the mechanism of action of cadmium, cobalt, mercury, methylmercury and nickel on various membrane transport systems in tissues including hepatic, ..
  62. Toxic Metal Complexation by de Novo Designed Peptides
    VINCENT PECORARO; Fiscal Year: 2009
    Abstract Heavy metal poisoning by elements such as mercury, lead, cadmium, and arsenic is a significant human health problem...
  63. Toxic Metal Complexation by de Novo Designed Peptides
    Vincent L Pecoraro; Fiscal Year: 2010
    Abstract Heavy metal poisoning by elements such as mercury, lead, cadmium, and arsenic is a significant human health problem...
  64. Phytochelatin synthase & resistance to heavy metals
    JULIAN SCHROEDER; Fiscal Year: 2000
    Soils and waters with high levels of toxic metals such as cadmium (Cd), arsenic (As), lead (Pb) and mercury (Hg) are detrimental to human and environmental health...
  65. The association of lead and cadmium exposure with kidney function in children
    Jeffrey Fadrowski; Fiscal Year: 2007
    ..Recent research suggests environmental exposure to lead or cadmium, even at levels considered "non-toxic" by current federal government standards, potentially accelerates kidney ..
  66. The association of lead and cadmium exposure with kidney function in children
    JEFFREY JOHN FADROWSKI; Fiscal Year: 2010
    ..Recent research suggests environmental exposure to lead or cadmium, even at levels considered "non-toxic" by current federal government standards, potentially accelerates kidney ..
  67. The association of lead and cadmium exposure with kidney function in children
    Jeffrey Fadrowski; Fiscal Year: 2009
    ..Recent research suggests environmental exposure to lead or cadmium, even at levels considered "non-toxic" by current federal government standards, potentially accelerates kidney ..
  68. Dietary and Environmental Exposure to Cadmium and the Risk of Endometrial Cancer
    Rudolph P Rull; Fiscal Year: 2010
    ..b>Cadmium is a trace metal released into air and soil as a byproduct of industrial processes and is perhaps the most potent ..
  69. Catalytic DNA Biosensor for Toxic Metal Ions
    Yi Lu; Fiscal Year: 2005
    ..real-time, and cost-effective detection and quantification of multiple heavy metal ions, such as mercury, cadmium and lead, simultaneously will be explored...
  70. Portable Analyzer for On-site Monitoring of Worker Exposure to Toxic Metals
    Wassana Yantasee; Fiscal Year: 2006
    ..provided by applicant): Large numbers of industrial workers are regularly exposed to toxic heavy metals like cadmium (Cd), lead (Pb), and mercury (Hg), which are known to induce various diseases that are detrimental to human ..
  71. Portable Analyzer for On-site Monitoring of Worker Exposure to Toxic Metals
    Charles Timchalk; Fiscal Year: 2007
    ..provided by applicant): Large numbers of industrial workers are regularly exposed to toxic heavy metals like cadmium (Cd), lead (Pb), and mercury (Hg), which are known to induce various diseases that are detrimental to human ..
  72. Epigenetic Effects of Particles and Metals on Cardiac Health of an Aging Cohort
    Joel Schwartz; Fiscal Year: 2007
    ..the increased risk of CVD observed in subjects exposed to air particles and toxic metals (such as arsenic, cadmium and lead) is mediated by alterations of DNA-methylation patterns is unresolved...
  73. Metal Toxicant Effects on Small Heat-Shock Proteins in Muscle
    Michael Welsh; Fiscal Year: 2001
    Toxic metals such as arsenic, cadmium and mercury induce the cellular stress response that, in part, results in increased expression and phosphorylation of the small heat-shock protein (sHSP) hsp27 as well as other sHSPs...
  74. Epigenetic Effects of Particles and Metals on Cardiac Health of an Aging Cohort
    Joel Schwartz; Fiscal Year: 2006
    ..the increased risk of CVD observed in subjects exposed to air particles and toxic metals (such as arsenic, cadmium and lead) is mediated by alterations of DNA-methylation patterns is unresolved...
  75. Epigenetic Effects of Particles and Metals on Cardiac Health of an Aging Cohort
    Joel Schwartz; Fiscal Year: 2009
    ..the increased risk of CVD observed in subjects exposed to air particles and toxic metals (such as arsenic, cadmium and lead) is mediated by alterations of DNA-methylation patterns is unresolved...
  76. Understanding the Effects of Cadmium on Breast Cancer Cell Growth
    Maggie Louie; Fiscal Year: 2007
    ..A potential mechanism may involve endocrine disruptors including heavy metals such as cadmium. Studies have suggested that cadmium may enhance the ER function and promote the development of breast cancer...
  77. Environmental & Genetic Risk Factors for Renal Function
    Virginia Weaver; Fiscal Year: 2006
    ..exposures has received relatively little attention in this regard, despite the fact that exposures such as cadmium and lead are known renal toxicants that are stored long-term in the body and ubiquitous in humans...
  78. Environmental & Genetic Risk Factors for Renal Function
    Virginia Weaver; Fiscal Year: 2009
    ..exposures has received relatively little attention in this regard, despite the fact that exposures such as cadmium and lead are known renal toxicants that are stored long-term in the body and ubiquitous in humans...
  79. Environmental & Genetic Risk Factors for Renal Function
    Virginia Weaver; Fiscal Year: 2005
    ..exposures has received relatively little attention in this regard, despite the fact that exposures such as cadmium and lead are known renal toxicants that are stored long-term in the body and ubiquitous in humans...
  80. Environmental & Genetic Risk Factors for Renal Function
    Virginia Weaver; Fiscal Year: 2003
    ..exposures has received relatively little attention in this regard, despite the fact that exposures such as cadmium and lead are known renal toxicants that are stored long-term in the body and ubiquitous in humans...
  81. Environmental & Genetic Risk Factors for Renal Function
    Virginia Weaver; Fiscal Year: 2004
    ..exposures has received relatively little attention in this regard, despite the fact that exposures such as cadmium and lead are known renal toxicants that are stored long-term in the body and ubiquitous in humans...
  82. CADMIUM TOXICOLOGY
    Curtis Klaassen; Fiscal Year: 1999
    DESCRIPTION: (Adapted from the Investigator's Abstract) Cadmium (Cd) is an environmental pollutant with high toxic potential. Over half of the body burden of Cd is concentrated in liver and kidney and bound to metallothionein (MT)...
  83. METAL MIXTURES AND CHILDREN'S HEALTH
    Joseph Brain; Fiscal Year: 2007
    ..of a community living in the Tar Creek Superfund site of Oklahoma - an area highly contaminated by metals (lead, cadmium, iron, manganese, and others) in mining waste and populated by many residents of Native American descent...
  84. METAL MIXTURES AND CHILDREN'S HEALTH
    Howard Hu; Fiscal Year: 2005
    ..of a community living in the Tar Creek Superfund site of Oklahoma - an area highly contaminated by metals (lead, cadmium, iron, manganese, and others) in mining waste and populated by many residents of Native American descent...
  85. CADMIUM TOXICOLOGY
    Curtis Klaassen; Fiscal Year: 2000
    DESCRIPTION: (Adapted from the Investigator's Abstract) Cadmium (Cd) is an environmental pollutant with high toxic potential. Over half of the body burden of Cd is concentrated in liver and kidney and bound to metallothionein (MT)...
  86. METAL MIXTURES AND CHILDREN'S HEALTH
    Howard Hu; Fiscal Year: 2006
    ..of a community living in the Tar Creek Superfund site of Oklahoma - an area highly contaminated by metals (lead, cadmium, iron, manganese, and others) in mining waste and populated by many residents of Native American descent...
  87. Lung Lysyl Oxidase Regulation by Metal Ion Homeostasis
    Wande Li; Fiscal Year: 2009
    ..Chronic exposure of humans to cadmium (Cd), a heavy metal, either from occupational contamination or from cigarette smoke, induces emphysema and lung ..