boron

Summary

Summary: A trace element with the atomic symbol B, atomic number 5, and atomic weight 10.81. Boron-10, an isotope of boron, is used as a neutron absorber in BORON NEUTRON CAPTURE THERAPY.

Top Publications

  1. ncbi A bystander effect observed in boron neutron capture therapy: a study of the induction of mutations in the HPRT locus
    Yuko Kinashi
    Research Reactor Institute, Kyoto University, Osaka, Japan
    Int J Radiat Oncol Biol Phys 68:508-14. 2007
  2. doi High-level exposure to lithium, boron, cesium, and arsenic via drinking water in the Andes of northern Argentina
    Gabriela Concha
    Division of Toxicology, Swedish National Food Administration, Box 622, S 751 26 Uppsala, Sweden
    Environ Sci Technol 44:6875-80. 2010
  3. ncbi Structural identification of a bacterial quorum-sensing signal containing boron
    Xin Chen
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    Nature 415:545-9. 2002
  4. doi Microbial diversity of boron-rich volcanic hot springs of St. Lucia, Lesser Antilles
    Lisa M Stout
    Department of Geology and Geophysics, Yale University, New Haven, CT 06520, USA
    FEMS Microbiol Ecol 70:402-12. 2009
  5. doi Proliferation, differentiation and gene expression of osteoblasts in boron-containing associated with dexamethasone deliver from mesoporous bioactive glass scaffolds
    Chengtie Wu
    Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, People s Republic of China
    Biomaterials 32:7068-78. 2011
  6. doi The analysis of Lupinus albus root proteome revealed cytoskeleton altered features due to long-term boron deficiency
    M Alves
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Av da Republica, 2780 157 Oeiras, Portugal
    J Proteomics 74:1351-63. 2011
  7. doi WRKY6 is involved in the response to boron deficiency in Arabidopsis thaliana
    Ichiro Kasajima
    Biotechnology Research Center, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Physiol Plant 139:80-92. 2010
  8. doi Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA)
    Roger Henriksson
    Department of Radiation Sciences and Oncology, Umea University, Umea, Sweden
    Radiother Oncol 88:183-91. 2008
  9. doi In vivo evolutionary engineering of a boron-resistant bacterium: Bacillus boroniphilus
    Mustafa Sen
    Department of Molecular Biology and Genetics, Faculty of Science and Letters, Istanbul Technical University, Istanbul, Maslak, 34469, Turkey
    Antonie Van Leeuwenhoek 99:825-35. 2011
  10. pmc Boron transport in plants: co-ordinated regulation of transporters
    Kyoko Miwa
    Creative Research Initiative Sousei, Hokkaido University, Kita ku, Sapporo, Hokkaido 001 0021, Japan
    Ann Bot 105:1103-8. 2010

Research Grants

  1. Catalytic C-H Activation and Boronic Acid Synthesis
    Milton Smith; Fiscal Year: 2004
  2. Boronated nucleosides for neutron capture therapy of brain tumors
    Werner Tjarks; Fiscal Year: 2010
  3. TUMOR-TARGETING WITH NEW BORONATED PORPHYRINS
    MARIA DA GRACA VICENTE; Fiscal Year: 2009
  4. TUMOR-TARGETING WITH NEW BORONATED PORPHYRINS
    MARIA DA GRACA HENRIQUES VICENTE; Fiscal Year: 2010
  5. TUMOR-TARGETING WITH NEW BORONATED PORPHYRINS
    MARIA DA GRACA VICENTE; Fiscal Year: 2006
  6. Boronated nucleosides for neutron capture therapy of brain tumors
    Werner Tjarks; Fiscal Year: 2011
  7. An Epithermal Neutron Source for Cancer Therapy
    MELVIN PIESTRUP; Fiscal Year: 2006
  8. SUPERHEATED DROP DETECTORS FOR DOSIMETRY IN RADIOTHERAPY
    Ravinder Nath; Fiscal Year: 2001
  9. Phase I / II Trial for Neutron Capture Therapy
    Matthew Palmer; Fiscal Year: 2002
  10. A Phase II Trial for Neutron Capture Therapy in Melanoma
    Paul Busse; Fiscal Year: 2003

Detail Information

Publications265 found, 100 shown here

  1. ncbi A bystander effect observed in boron neutron capture therapy: a study of the induction of mutations in the HPRT locus
    Yuko Kinashi
    Research Reactor Institute, Kyoto University, Osaka, Japan
    Int J Radiat Oncol Biol Phys 68:508-14. 2007
    To investigate bystander mutagenic effects induced by alpha-particles during boron neutron capture therapy, we mixed cells that were electroporated with borocaptate sodium (BSH), which led to the accumulation of (10)B inside the cells, ..
  2. doi High-level exposure to lithium, boron, cesium, and arsenic via drinking water in the Andes of northern Argentina
    Gabriela Concha
    Division of Toxicology, Swedish National Food Administration, Box 622, S 751 26 Uppsala, Sweden
    Environ Sci Technol 44:6875-80. 2010
    ..high concentrations of lithium (highest 1000 microg/L), cesium (320 microg/L), rubidium (47 microg/L), and boron (5950 microg/L)...
  3. ncbi Structural identification of a bacterial quorum-sensing signal containing boron
    Xin Chen
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    Nature 415:545-9. 2002
    ..Furthermore, they indicate a potential biological role for boron, an element required by a number of organisms but for unknown reasons.
  4. doi Microbial diversity of boron-rich volcanic hot springs of St. Lucia, Lesser Antilles
    Lisa M Stout
    Department of Geology and Geophysics, Yale University, New Haven, CT 06520, USA
    FEMS Microbiol Ecol 70:402-12. 2009
    ..present an extreme environment due to high temperatures, low pH values, and high concentrations of sulfate and boron. St...
  5. doi Proliferation, differentiation and gene expression of osteoblasts in boron-containing associated with dexamethasone deliver from mesoporous bioactive glass scaffolds
    Chengtie Wu
    Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, People s Republic of China
    Biomaterials 32:7068-78. 2011
    b>Boron is one of the trace elements in the human body which plays an important role in bone growth...
  6. doi The analysis of Lupinus albus root proteome revealed cytoskeleton altered features due to long-term boron deficiency
    M Alves
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Av da Republica, 2780 157 Oeiras, Portugal
    J Proteomics 74:1351-63. 2011
    b>Boron (B) deficiency greatly limits plants' growth and development. Since the root is the organ that first senses the deficiency, we have analyzed the adaptive responses of Lupinus albus roots to long-term B deficiency...
  7. doi WRKY6 is involved in the response to boron deficiency in Arabidopsis thaliana
    Ichiro Kasajima
    Biotechnology Research Center, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Physiol Plant 139:80-92. 2010
    b>Boron (B) is one of the essential nutrients for plant growth and reproduction. Transcriptome analyses have identified genes regulated by B deficiency, but their function mostly remains elusive...
  8. doi Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA)
    Roger Henriksson
    Department of Radiation Sciences and Oncology, Umea University, Umea, Sweden
    Radiother Oncol 88:183-91. 2008
    To evaluate the efficacy and safety of boron neutron capture therapy (BNCT) for glioblastoma multiforme (GBM) using a novel protocol for the boronophenylalanine-fructose (BPA-F) infusion.
  9. doi In vivo evolutionary engineering of a boron-resistant bacterium: Bacillus boroniphilus
    Mustafa Sen
    Department of Molecular Biology and Genetics, Faculty of Science and Letters, Istanbul Technical University, Istanbul, Maslak, 34469, Turkey
    Antonie Van Leeuwenhoek 99:825-35. 2011
    b>Boron is an industrially and biologically important element. However, the mechanisms of boron tolerance and its transport in bacteria and many other living systems are still not clearly understood...
  10. pmc Boron transport in plants: co-ordinated regulation of transporters
    Kyoko Miwa
    Creative Research Initiative Sousei, Hokkaido University, Kita ku, Sapporo, Hokkaido 001 0021, Japan
    Ann Bot 105:1103-8. 2010
    The essentiality of boron (B) for plant growth was established > 85 years ago...
  11. pmc Cell-type specificity of the expression of Os BOR1, a rice efflux boron transporter gene, is regulated in response to boron availability for efficient boron uptake and xylem loading
    Yuko Nakagawa
    Biotechnology Research Center, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Plant Cell 19:2624-35. 2007
    We describe a boron (B) transporter, Os BOR1, in rice (Oryza sativa)...
  12. ncbi Boron neutron capture therapy for glioblastoma multiforme: clinical studies in Sweden
    Jacek Capala
    Studsvik Medical AB, Nykoping, Sweden
    J Neurooncol 62:135-44. 2003
    A boron neutron capture therapy (BNCT) facility has been constructed at Studsvik, Sweden. It includes two filter/moderator configurations...
  13. doi VvBOR1, the grapevine ortholog of AtBOR1, encodes an efflux boron transporter that is differentially expressed throughout reproductive development of Vitis vinifera L
    Ramón Perez-Castro
    Instituto de Biologia Vegetal y Biotecnologia, Universidad de Talca, Talca, Chile
    Plant Cell Physiol 53:485-94. 2012
    b>Boron (B) is an essential micronutrient for normal development of roots, shoots and reproductive tissues in plants...
  14. pmc Antagonistic actions of boron against inhibitory effects of aluminum toxicity on growth, CO2 assimilation, ribulose-1,5-bisphosphate carboxylase/oxygenase, and photosynthetic electron transport probed by the JIP-test, of Citrus grandis seedlings
    Huan Xin Jiang
    Institute of Horticultural Plant Physiology, Biochemistry and Molecular Biology, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China
    BMC Plant Biol 9:102. 2009
    Little information is available on the amelioration of boron (B) on aluminum (Al)-induced photosynthesis inhibition. Sour pummelo (Citrus grandis) seedlings were irrigated for 18 weeks with nutrient solution containing 4 B levels (2...
  15. pmc Identification of a novel system for boron transport: Atr1 is a main boron exporter in yeast
    Alaattin Kaya
    Department of Molecular Biology and Genetics, Izmir Institute of Technology, 35430 Urla, Izmir, Turkey
    Mol Cell Biol 29:3665-74. 2009
    b>Boron is a micronutrient in plants and animals, but its specific roles in cellular processes are not known...
  16. ncbi Properties of hybridized DNA arrays on single-crystalline undoped and boron-doped (100) diamonds studied by atomic force microscopy in electrolytes
    Bohuslav Rezek
    Diamond Research Center, AIST, Central 2, Tsukuba 305 8568, Japan
    Langmuir 23:7626-33. 2007
    Properties of hybridized deoxyribonucleic acid (DNA) arrays on single-crystalline undoped and boron-doped diamonds are studied at the microscopic level by atomic force microscopy (AFM) in buffered electrolytic solutions...
  17. ncbi Roles of BOR1, DUR3, and FPS1 in boron transport and tolerance in Saccharomyces cerevisiae
    Akira Nozawa
    Precursory Research for Embryonic Science and Technology, Saitama, Japan
    FEMS Microbiol Lett 262:216-22. 2006
    The roles of three membrane proteins, BOR1, DUR3, and FPS1, in boron (B) transport in yeast were examined...
  18. pmc Increased abundance of proteins involved in phytosiderophore production in boron-tolerant barley
    John Patterson
    Australian Centre for Plant Functional Genomics, School of Botany, University of Melbourne, Victoria, Australia
    Plant Physiol 144:1612-31. 2007
    b>Boron (B) phytotoxicity affects cereal-growing regions worldwide. Although B-tolerant barley (Hordeum vulgare) germplasm is available, molecules responsible for this tolerance mechanism have not been defined...
  19. pmc High boron-induced ubiquitination regulates vacuolar sorting of the BOR1 borate transporter in Arabidopsis thaliana
    Koji Kasai
    Biotechnology Research Center, University of Tokyo, Tokyo 113 8657, Japan
    J Biol Chem 286:6175-83. 2011
    b>Boron homeostasis is important for plants, as boron is essential but is toxic in excess...
  20. doi Selection of salt and boron tolerant selenium hyperaccumulator Stanleya pinnata genotypes and characterization of Se phytoremediation from agricultural drainage sediments
    John L Freeman
    Agricultural Research Service, US Department of Agriculture, Parlier, California 93648, United States
    Environ Sci Technol 45:9703-10. 2011
    Genetic variation in salt (Na(2)SO(4), NaCl) and boron (B) tolerance among four ecotypes of the selenium (Se) hyperaccumulator Stanleya pinnata (Pursh) Britton was utilized to select tolerant genotypes capable of phytoremediating Se from ..
  21. doi Selectively induced death of macrophages in the synovial lining of murine knee joints using 10B-liposomes and boron neutron capture synovectomy
    Peter L E M van Lent
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Radiat Biol 85:860-71. 2009
    ..whether macrophages in the synovial lining can be selectively eliminated by local administration of an improved boron-10 ((10)B) containing liposome formulation combined with neutron irradiation (boron neutron capture synovectomy [..
  22. doi Transcriptome-wide identification of R2R3-MYB transcription factors in barley with their boron responsive expression analysis
    Huseyin Tombuloglu
    Department of Biology, Faculty of Arts and Science, Fatih University, Buyukcekmece, Istanbul, Turkey
    Mol Genet Genomics 288:141-55. 2013
    ..the identification of barley R2R3-MYB TFs including their expression analysis in tissues under control and Boron (B) toxic conditions...
  23. doi Boron uptake in normal melanocytes and melanoma cells and boron biodistribution study in mice bearing B16F10 melanoma for boron neutron capture therapy
    Fernanda Faião-Flores
    Laboratory of Biochemistry and Biophysics, Butantan Institute, 1500 Vital Brasil Avenue, Sao Paulo, SP 05503 900, Brazil
    Radiat Environ Biophys 51:319-29. 2012
    Information on (10)B distribution in normal tissues is crucial to any further development of boron neutron capture therapy (BNCT)...
  24. doi Boron deficiency results in induction of pathogenesis-related proteins from the PR-10 family during the legume-rhizobia interaction
    María Reguera
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, Darwin 2, 28049 Madrid, Spain
    J Plant Physiol 167:625-32. 2010
    b>Boron (B) deficiency has a strong effect on molecular and cellular plant-bacteria interactions during the development of the legume-rhizobia symbiosis, leading to reduced infection and early necrosis of nodules, resembling a pathogenic-..
  25. ncbi Boron nutrition of cultured tobacco BY-2 cells. III. Characterization of the boron-rhamnogalacturonan II complex in cells acclimated to low levels of boron
    T Matoh
    Division of Applied Life Sciences, Faculty of Agriculture, Kyoto University, Japan
    Plant Cell Physiol 41:363-6. 2000
    ..BY-2 which could propagate at the same rate as the parent cells (1 mg B liter(-1)) under a lower level of boron (0.01 mg B liter(-1)) were obtained. The selected cells had swollen cell walls...
  26. ncbi In vitro induction of matrix metalloproteinase-2 and matrix metalloproteinase-9 expression in keratinocytes by boron and manganese
    Nathalie Chebassier
    Department of Dermatology, INSERM U463, CHU Hotel Dieu, Nantes, France
    Exp Dermatol 13:484-90. 2004
    ..Some thermal waters are rich in trace elements such as boron and manganese...
  27. ncbi Boron concentrations in milk from mothers of full-term and premature infants
    Curtiss D Hunt
    US Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND, USA
    Am J Clin Nutr 80:1327-33. 2004
    b>Boron is a bioactive element that satisfies several of the criteria for essentiality in humans.
  28. ncbi Quantitative imaging and microlocalization of boron-10 in brain tumors and infiltrating tumor cells by SIMS ion microscopy: relevance to neutron capture therapy
    D R Smith
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA
    Cancer Res 61:8179-87. 2001
    b>Boron neutron capture therapy (BNCT) is dependent on the selective accumulation of boron-10 in tumor cells relative to the contiguous normal cells...
  29. pmc Enantioselective synthesis of homoallylic amines through reactions of (pinacolato)allylborons with aryl-, heteroaryl-, alkyl-, or alkene-substituted aldimines catalyzed by chiral C1-symmetric NHC-Cu complexes
    Erika M Vieira
    Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, United States
    J Am Chem Soc 133:3332-5. 2011
    ..5:1.5 enantiomeric ratio and are amenable to gram-scale operations. A mechanistic model accounting for the observed selectivity levels and trends is proposed...
  30. ncbi Assessment of the results from the phase I/II boron neutron capture therapy trials at the Brookhaven National Laboratory from a clinician's point of view
    Aidnag Z Diaz
    Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Neurooncol 62:101-9. 2003
    b>Boron neutron capture therapy (BNCT) represents a promising modality for a relatively selective radiation dose delivery to the tumor tissue...
  31. doi Degradation of Acid Orange 7 by electrochemically generated (*)OH radicals in acidic aqueous medium using a boron-doped diamond or platinum anode: a mechanistic study
    Samiha Hammami
    Universite Paris Est, Laboratoire des Géomatériaux et Géologie de l Ingénieur, Bat IFI, 5 Boulevard Descartes, 77454 Marne la Vallee Cedex 2, France
    Chemosphere 73:678-84. 2008
    ..0 by electro-Fenton process using Pt or boron-doped diamond (BDD) anode was reported...
  32. doi Assessment of the potential of a boron-fructose additive in counteracting the toxic effect of Fusarium mycotoxins
    Ionelia Taranu
    INCDBNA, National Institute of Research and Development for Biology and Animal Nutrition, 1, Calea Bucuresti, 077015 Balotesti, Romania
    Br J Nutr 106:398-407. 2011
    ..However, consumption of CFrB did not counteract the effect of mycotoxins on biochemistry parameters, and increased plasma IgM and IgG of contaminated pigs...
  33. pmc Boron-dependent degradation of NIP5;1 mRNA for acclimation to excess boron conditions in Arabidopsis
    Mayuki Tanaka
    Graduate School of Agricultural and Life Science, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Plant Cell 23:3547-59. 2011
    b>Boron (B) is an essential plant micronutrient that is toxic at higher levels. NIP5;1 is a boric acid channel required for B uptake and growth under B deficiency...
  34. doi Boron and fish oil have different beneficial effects on strength and trabecular microarchitecture of bone
    Forrest H Nielsen
    US Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, 2420 2nd Avenue North, Stop 9034, Grand Forks, ND 58202 9034, USA
    J Trace Elem Med Biol 23:195-203. 2009
    An experiment was performed to determine whether boron deprivation would adversely affect vertebra (trabecular) bone microarchitecture, and whether any adverse effect would be modified by dietary fatty acid composition...
  35. doi Palladium-catalyzed, stereoselective, cyclizative alkenylboration of carbon-carbon double bonds through activation of a boron-chlorine bond
    Masaki Daini
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Kyoto 615 8510, Japan
    J Am Chem Soc 133:4758-61. 2011
    ..Cross-coupling of the resultant products with aryl iodides proceeds with retention of configuration at the boron-bound secondary carbon atom.
  36. pmc The aromatic/arginine selectivity filter of NIP aquaporins plays a critical role in substrate selectivity for silicon, boron, and arsenic
    Namiki Mitani-Ueno
    Institute of Plant Science and Resources, Okayama University, Chuo 2 20 1, Kurashiki 710 0046, Japan
    J Exp Bot 62:4391-8. 2011
    ..The results reveal that the residue at the H5 position of the ar/R filter of both OsLsi1 and AtNIP5;1 plays a key role in the permeability to Si and B, but there is a relatively low selectivity for arsenite...
  37. ncbi Boron neutron capture therapy of brain tumors: clinical trials at the finnish facility using boronophenylalanine
    Heikki Joensuu
    Department of Oncology, University of Helsinki, Finland
    J Neurooncol 62:123-34. 2003
    Two clinical trials are currently running at the Finnish dedicated boron neutron capture therapy (BNCT) facility...
  38. ncbi Effects of boron and calcium supplementation on mechanical properties of bone in rats
    Mohammad Reza Naghii
    Department of Nutrition, Faculty of Health, Baqiyatallah a s University of Medical Sciences, Tehran, Iran
    Biofactors 28:195-201. 2006
    The objective of this study was to consider the effects of boron (B) and calcium (Ca) supplementation on mechanical properties of bone tissues and mineral content of the selected bones in rats.
  39. ncbi Boron concentrations in milk from mothers of exclusively breast-fed healthy full-term infants are stable during the first four months of lactation
    Curtiss D Hunt
    U S Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND, USA
    J Nutr 135:2383-6. 2005
    Because boron is a bioactive element that satisfies several of the criteria for essentiality in humans, the aim of the present work was to determine the profile of boron metabolism in human milk during the first 4 mo of lactation...
  40. ncbi Identification of boron transporter genes likely to be responsible for tolerance to boron toxicity in wheat and barley
    Rob Reid
    School of Earth and Environmental Sciences, University of Adelaide, Adelaide 5005, Australia
    Plant Cell Physiol 48:1673-8. 2007
    Tolerance to boron (B) toxicity in cereals is known to be associated with reduced tissue accumulation of B...
  41. doi Overexpression of the tonoplast aquaporin AtTIP5;1 conferred tolerance to boron toxicity in Arabidopsis
    Yongqi Pang
    State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, China
    J Genet Genomics 37:389-97, 1-2. 2010
    b>Boron (B) toxicity to plants is responsible for low crop productivity in many regions of the world. Here we report a novel and effective means to alleviate the B toxicity to plants under high B circumstance...
  42. pmc Germanium does not substitute for boron in cross-linking of rhamnogalacturonan II in pumpkin cell walls
    Tadashi Ishii
    National Agricultural Research Center for Kyushu Okinawa Region, Nishigoshi, Kumamoto 861 1192, Japan
    Plant Physiol 130:1967-73. 2002
    b>Boron (B)-deficient pumpkin (Cucurbita moschata Duchesne) plants exhibit reduced growth, and their tissues are brittle...
  43. doi Boron and other elements in sporophores of ectomycorrhizal and saprotrophic fungi
    Anu Lavola
    University of Eastern Finland, School of Forest Sciences, P O Box 111, 80101 Joensuu, Finland
    Mycorrhiza 21:155-65. 2011
    Fungi are usually thought not to have a boron (B) requirement. It is not known if mycorrhizas take up B from low concentrations that are common in forest soils, as fungi might also immobilise B...
  44. doi Analysis of boron content in frequently consumed foods in Korea
    Mi Kyeong Choi
    Department of Human Nutrition and Food Science, Chungwoon University, Chungnam 350 701, South Korea
    Biol Trace Elem Res 126:13-26. 2008
    This study analyzed boron content in commonly consumed foods by Koreans. Boron content was analyzed on 299 different foods using inductively coupled plasma atomic emission spectroscopy...
  45. ncbi Evaluation of the genotoxic effects of the boron neutron capture reaction in human melanoma cells using the cytokinesis block micronucleus assay
    N G Oliveira
    Department of Genetics, Faculty of Medical Sciences, New University of Lisbon, Portugal
    Mutagenesis 16:369-75. 2001
    The present work reports on the genotoxicity of the boron neutron capture (BNC) reaction in human metastatic melanoma cells (A2058) assessed by the cytokinesis block micronucleus assay (CBMN) using p-borono-L-phenylalanine (BPA) as the ..
  46. doi Morphology and oxidative physiology of boron-deficient mulberry plants
    Rajesh Kumar Tewari
    Department of Botany, University of Lucknow, Lucknow 226007, India
    Tree Physiol 30:68-77. 2010
    ..11.1.11) were increased in B-deficient leaves. The activities of SOD and POD were decreased in B-supraoptimal plants. The results suggest that B deficiency aggravates oxidative stress through enhanced generation of ROS in mulberry plants...
  47. ncbi Involvement of auxin and CKs in boron deficiency induced changes in apical dominance of pea plants (Pisum sativum L.)
    Guoying Wang
    Department of Plant Nutrition, China Agricultural University, 100094 Beijing, China
    J Plant Physiol 163:591-600. 2006
    It has previously been shown that boron (B) deficiency inhibits growth of the plant apex, which consequently results in a relatively weak apical dominance, and a subsequent sprouting of lateral buds...
  48. doi Probing properties of boron alpha-tubes by Ab Initio calculations
    Abhishek K Singh
    Department of Mechanical Engineering and Materials Science and Department of Chemistry, Rice University, Houston, Texas 77005, USA
    Nano Lett 8:1314-7. 2008
    We investigate the properties of nanotubes obtained from recently described boron alpha-sheet, using density functional theory. Computations confirm their high stability and identify mechanical stiffness parameters...
  49. doi Salt stress aggravates boron toxicity symptoms in banana leaves by impairing guttation
    O R Shapira
    The Robert H Smith Institute of Plant Sciences and Genetics in Agriculture, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Plant Cell Environ 36:275-87. 2013
    b>Boron (B) is known to accumulate in the leaf margins of different plant species, arguably a passive consequence of enhanced transpiration at the ends of the vascular system...
  50. doi Boron analysis and boron imaging in biological materials for Boron Neutron Capture Therapy (BNCT)
    Andrea Wittig
    Department of Radiation Oncology, University Duisburg Essen, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Crit Rev Oncol Hematol 68:66-90. 2008
    b>Boron Neutron Capture Therapy (BNCT) is based on the ability of the stable isotope 10B to capture neutrons, which leads to a nuclear reaction producing an alpha- and a 7Li-particle, both having a high biological effectiveness and a very ..
  51. ncbi Dose and time dependent apoptotic response in a human melanoma cell line exposed to accelerated boron ions at four different LET
    A E Meijer
    Department of Oncology Pathology, Division of Medical Radiation Physics, Karolinska Institutet, Stockholm, Sweden
    Int J Radiat Biol 81:261-72. 2005
    ..LET), dose and time on the induction of apoptosis in a human melanoma cell line exposed to accelerated light boron ((10)B) ions and photons...
  52. ncbi Chimaereicella boritolerans sp. nov., a boron-tolerant and alkaliphilic bacterium of the family Flavobacteriaceae isolated from soil
    Iftikhar Ahmed
    Biotechnology Research Center, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Int J Syst Evol Microbiol 57:986-92. 2007
    A non-motile, Gram-negative, boron-tolerant and alkaliphilic bacterium was isolated from soil of the Hisarcik area in the Kutahya Province of Turkey that was naturally high in boron minerals...
  53. doi Proteomic alterations of Brassica napus root in response to boron deficiency
    Zhifang Wang
    National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, 430070 Wuhan, China
    Plant Mol Biol 74:265-78. 2010
    b>Boron (B) deficiency is a worldwide problem, and Brassica napus is one of the most sensitive crops to B deficiency...
  54. pmc Biological evaluation of boronated unnatural amino acids as new boron carriers
    G W Kabalka
    Departments of Radiology and Chemistry, The University of Tennessee, Knoxville, TN, USA
    Appl Radiat Isot 67:S374-9. 2009
    There is a pressing need for new and more efficient boron delivery agents to tumor cells for use in boron neutron capture therapy (BNCT)...
  55. doi Boron deficiency and transcript level changes
    Juan J Camacho-Cristóbal
    Departamento de Fisiologia, Anatomía y Biología Celular, Universidad Pablo de Olavide, E 41013 Sevilla, Spain
    Plant Sci 181:85-9. 2011
    b>Boron (B) is an essential element for plant growth whose deficiency causes an alteration in the expression of a wide range of genes involved in several physiological processes...
  56. pmc Enhanced growth and osteogenic differentiation of human osteoblast-like cells on boron-doped nanocrystalline diamond thin films
    Lubica Grausova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    PLoS ONE 6:e20943. 2011
    ..the NCD films were deposited on silicon substrates by a microwave plasma-enhanced CVD process and their boron doping was achieved by adding trimethylboron to the CH(4):H(2) gas mixture, the B∶C ratio was 133, 1000 and 6700 ..
  57. doi A serendipitous phosphonocarboxylate complex of boron: when vessel becomes reagent
    Katarzyna M Błazewska
    Department of Chemistry, University of Southern California, Los Angeles, CA 90089 0744, USA
    Chem Commun (Camb) 47:6395-7. 2011
    ..drug minodronate (4) in contact with borosilicate glassware reversibly forms an isolable dimer complex of boron, as revealed by the X-ray crystallographic structure of the (R,R/S,S) complex and supported by NMR and HRMS data.
  58. doi Ultrasensitive microchip sensor based on boron-containing polyfluorene nanofilms
    Celso Ribeiro
    Centro de Investigação em Física Tecnológica, Physics Department, FCT UNL, 2829 516, Caparica, Portugal celso
    Biosens Bioelectron 26:1662-5. 2010
    ..Changes in the conductivity due to the boron-fluoride complex formation seem to be the major mechanism behind the dependence of impedimetric results on the ..
  59. doi Assessment of genotoxic effects of boron on wheat (Triticum aestivum L.) and bean (Phaseolus vulgaris L.) by using RAPD analysis
    Guzin Kekec
    Department of Biology, Fatih University, 34500 Istanbul, Turkey
    Bull Environ Contam Toxicol 84:759-64. 2010
    In boron-rich soils of Turkey, boron tolerant wheat (Triticum aestivum L.) and sensitive bean (Phaseolus vulgaris L.) are most widely cultivated crops...
  60. ncbi The effects of boron administration on plasma leptin and lactate levels in ovariectomized rats which had acute swimming exercise
    Zubeyde Yazici
    Department of Physical Education and Sports Sciences, Selcuk University, Konya Turkey, Turkey
    Neuro Endocrinol Lett 29:173-7. 2008
    The aim of this study was to investigate the effects of intraperitoneal (IP) boron administration on leptin and lactate levels in swimming exercise in ovariectomized rats.
  61. ncbi Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases
    Stephen J Baker
    Anacor Pharmaceuticals, Inc, 1060 E Meadow Circle, Palo Alto, CA 94303, USA
    Bioorg Med Chem Lett 16:5963-7. 2006
    ..This compound is now in clinical development for dermatological conditions...
  62. ncbi Amperometric biosensor based on tyrosinase immobilized on a boron-doped diamond electrode
    Yan Li Zhou
    Laboratory of Photoelectro Chemistry, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Zhong Guan Cun, Haidian District, Beijing 100080, People s Republic of China
    Biosens Bioelectron 22:822-8. 2007
    A novel method has been developed to immobilize tyrosinase onto the surface of boron-doped diamond (BDD) electrode...
  63. pmc Dissecting quantitative trait loci for boron efficiency across multiple environments in Brassica napus
    Zunkang Zhao
    National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, Hubei, China
    PLoS ONE 7:e45215. 2012
    High yield is the most important goal in crop breeding, and boron (B) is an essential micronutrient for plants. However, B deficiency, leading to yield decreases, is an agricultural problem worldwide...
  64. doi Carborane derivatives loaded into liposomes as efficient delivery systems for boron neutron capture therapy
    S Altieri
    Department of Nuclear and Theoretical Physics, University of Pavia and INFN, Pavia, Italy
    J Med Chem 52:7829-35. 2009
    b>Boron neutron capture therapy (BNCT) is an anticancer therapy based on the incorporation of (10)B in tumors, followed by neutron irradiation...
  65. pmc Condensin II alleviates DNA damage and is essential for tolerance of boron overload stress in Arabidopsis
    Takuya Sakamoto
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Plant Cell 23:3533-46. 2011
    Although excess boron (B) is known to negatively affect plant growth, its molecular mechanism of toxicity is unknown. We previously isolated two Arabidopsis thaliana mutants, hypersensitive to excess B (heb1-1 and heb2-1)...
  66. doi Metabolic analysis revealed altered amino acid profiles in Lupinus albus organs as a result of boron deficiency
    Marta Alves
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Av da Republica, Oeiras, Portugal
    Physiol Plant 142:224-32. 2011
    ..So our results bring new information concerning the effects of B deficiency in the metabolism of the several L. albus organs...
  67. ncbi Plants tolerant of high boron levels
    Kyoko Miwa
    Biotechnology Research Center, University of Tokyo, Tokyo 113 8657, Japan
    Science 318:1417. 2007
    Reduced crop productivity due to soils containing toxic levels of boron (B) is a worldwide problem in food production. It is estimated that up to 17% of the barley yield losses in southern Australia are caused by B toxicity...
  68. doi Suitability of boron carriers for BNCT: accumulation of boron in malignant and normal liver cells after treatment with BPA, BSH and BA
    F I Chou
    Nuclear Science and Technology Development Center, National Tsing Hua University, Taiwan, ROC
    Appl Radiat Isot 67:S105-8. 2009
    ..Therefore, boron neutron capture therapy (BNCT) may provide an alternative therapy for treatment of hepatocellular carcinoma...
  69. doi Genome-wide identification of genes that play a role in boron stress response in yeast
    Irem Uluisik
    Izmir Institute of Technology, Department of Molecular Biology and Genetics, 35430 Urla, Izmir, Turkey
    Genomics 97:106-11. 2011
    b>Boron is an essential micronutrient for plants and it is either necessary or beneficial for animals...
  70. pmc Diamond and biology
    Christoph E Nebel
    Diamond Research Center, AIST, Central 2, Tsukuba, Japan
    J R Soc Interface 4:439-61. 2007
    ..This leads to the formation of typically 25 A thick layers. The electrochemical bonding to boron-doped diamond works on H-terminated and oxidized surfaces...
  71. doi Boron in plants: deficiency and toxicity
    Juan J Camacho-Cristóbal
    Departamento de Fisiologia, Anatomía y Biología Celular, Facultad de Ciencias Experimentales, Universidad Pablo de Olavide, E 41013 Sevilla, Spain
    J Integr Plant Biol 50:1247-55. 2008
    b>Boron (B) is an essential nutrient for normal growth of higher plants, and B availability in soil and irrigation water is an important determinant of agricultural production...
  72. doi Quantitative evaluation of boron-induced disorder in multilayers containing silicon nanocrystals in an oxide matrix designed for photovoltaic applications
    G Zatryb
    Institute of Physics, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50 370 Wroclaw, Poland
    Opt Express 18:22004-9. 2010
    The effect of doping by boron on optical properties of multilayers containing Si-NCs were studied by means of photoluminescence (PL), time-resolved PL, photoluminescence excitation (PLE), transmission and reflection measurements...
  73. pmc Oxidative stress and antioxidants in tomato (Solanum lycopersicum) plants subjected to boron toxicity
    Luis M Cervilla
    Department of Plant Physiology, Faculty of Sciences, University of Granada, 18071 Granada, Spain
    Ann Bot 100:747-56. 2007
    b>Boron (B) toxicity triggers the formation of reactive oxygen species in plant tissues. However, there is still a lack of knowledge as to how B toxicity affects the plant antioxidant defence system...
  74. doi A novel carborane analog, BE360, with a carbon-containing polyhedral boron-cluster is a new selective estrogen receptor modulator for bone
    Michiko Hirata
    Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2 24 16 Nakamachi, Koganei, Tokyo 184 8588, Japan
    Biochem Biophys Res Commun 380:218-22. 2009
    Carboranes are a class of carbon-containing polyhedral boron-cluster compounds with globular geometry and hydrophobic surface that interact with hormone receptors...
  75. doi Neutron autoradiography imaging of selective boron uptake in human metastatic tumours
    S Altieri
    Department of Nuclear and Theoretical Physics, University of Pavia, Pavia, Italy
    Appl Radiat Isot 66:1850-5. 2008
    The ability to selectively hit the tumour cells is an essential characteristic of an anti-tumour therapy. In boron neutron capture therapy (BNCT) this characteristic is based on the selective uptake of (10)B in the tumour cells with ..
  76. doi Simultaneous square-wave voltammetric determination of aspartame and cyclamate using a boron-doped diamond electrode
    Roberta Antigo Medeiros
    Departamento de Quimica, Universidade Federal de Sao Carlos, C P 676, 13560 970 Sao Carlos, SP, Brazil
    Talanta 76:685-9. 2008
    ..method was developed for the simultaneous determination of aspartame and cyclamate in dietary products at a boron-doped diamond (BDD) electrode...
  77. ncbi Rhodococcus baikonurensis BTM4c, a boron-tolerant actinobacterial strain isolated from soil
    Jaewoo Yoon
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Biosci Biotechnol Biochem 74:178-81. 2010
    By screening a bacterial population from the soil in Tokyo, Japan, we isolated a boron-tolerant bacterium, strain BTM4c. Strain BTM4c grew under the boron excess conditions with 100 mM boric acid, which is generally toxic to bacteria...
  78. ncbi Electrochemical analysis of chloramphenicol using boron-doped diamond electrode applied to a flow-injection system
    Suchada Chuanuwatanakul
    Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
    Anal Sci 24:493-8. 2008
    The electrochemical properties of chloramphenicol at a boron-doped diamond thin-film (BDD) electrode were studied using cyclic voltammetry. The highest current response of chloramphenicol was obtained with phosphate buffer, pH 6 (0...
  79. doi Inhibitory effect of boron against Botrytis cinerea on table grapes and its possible mechanisms of action
    Guozheng Qin
    Research Center for Molecular and Developmental Biology, Institute of Botany, Chinese Academy of Sciences, Beijing, China
    Int J Food Microbiol 138:145-50. 2010
    b>Boron, an essential plant micronutrient, was effective in the form of potassium tetraborate for control of postharvest gray mold caused by Botrytis cinerea on table grapes stored at room temperature or at 0 degrees C...
  80. pmc Dietary boron and hormone replacement therapy as risk factors for lung cancer in women
    S Mahabir
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Epidemiol 167:1070-80. 2008
    Hormone replacement therapy (HRT) may reduce lung cancer risk. Dietary boron may have actions similar to those of HRT; however, no previous study has reported the associations between dietary boron intake and lung cancer risk or the ..
  81. pmc Polar localization and degradation of Arabidopsis boron transporters through distinct trafficking pathways
    Junpei Takano
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    Proc Natl Acad Sci U S A 107:5220-5. 2010
    b>Boron (B) is essential for plant growth but is toxic when present in excess...
  82. doi Boron neutron capture therapy for glioblastoma
    Tetsuya Yamamoto
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Tenno dai 1 1 1, Tsukuba City, Ibaraki 305 8575, Japan
    Cancer Lett 262:143-52. 2008
    b>Boron neutron capture therapy (BNCT) theoretically allows the preferential destruction of tumor cells while sparing the normal tissue, even if the cells have microscopically spread to the surrounding normal brain...
  83. doi Boron toxicity is alleviated by hydrogen sulfide in cucumber (Cucumis sativus L.) seedlings
    Bao Lan Wang
    State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, The Chinese Academy of Sciences, Beijing 100093, People s Republic of China
    Planta 231:1301-9. 2010
    b>Boron (B) is an essential micronutrient for plants, which when occurs in excess in the growth medium, becomes toxic to plants. Rapid inhibition of root elongation is one of the most distinct symptoms of B toxicity...
  84. ncbi Physiological roles and transport mechanisms of boron: perspectives from plants
    Mayuki Tanaka
    Biotechnology Research Center, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo, Japan
    Pflugers Arch 456:671-7. 2008
    b>Boron, an orphan of the periodic table of the elements, is unique not only in its chemical properties but also in its roles in biology. Its requirement in plants was described more than 80 years ago...
  85. pmc Boron toxicity tolerance in barley through reduced expression of the multifunctional aquaporin HvNIP2;1
    Thorsten Schnurbusch
    Australian Centre for Plant Functional Genomics, University of Adelaide, Waite Campus, Urrbrae, South Australia 5064, Australia
    Plant Physiol 153:1706-15. 2010
    b>Boron (B) toxicity is a significant limitation to cereal crop production in a number of regions worldwide...
  86. ncbi Estimation of human daily boron exposure in a boron-rich area
    Mehmet Korkmaz
    Department of Medical Biology, Faculty of Medicine, Yuzuncu Yil University, 65200 Van, Turkey
    Br J Nutr 98:571-5. 2007
    Although, the safe limits of human daily boron (B) exposure are not absolutely clear, there is a growing interest in B and its effects on human health...
  87. ncbi Why boron?
    Luis Bolaños
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Plant Physiol Biochem 42:907-12. 2004
    It is now more than 80 years since boron was convincingly demonstrated to be essential for normal growth of higher plants. However, its biochemical role is not well understood at the moment...
  88. doi 3D-QSAR studies of boron-containing dipeptides as proteasome inhibitors with CoMFA and CoMSIA methods
    Yong Qiang Zhu
    Jiangsu Simcere Pharmaceutical Research Institute, No 699 18 Xuan Wu Avenue, Xuan Wu District, Nanjing 210042, PR China
    Eur J Med Chem 44:1486-99. 2009
    ....
  89. pmc Boron-containing aptamers to ATP
    Susan M Lato
    Department of Chemistry, Indiana University, 800 East Kirkwood, Bloomington, IN 47405 7102, USA
    Nucleic Acids Res 30:1401-7. 2002
    b>Boron neutron capture therapy (BNCT), an experimental treatment for certain cancers, destroys only cells near the boron; however, there is a need to develop highly specific delivery agents...
  90. ncbi Boron nutrition of cultured tobacco BY-2 cells. IV. Genes induced under low boron supply
    Masaru Kobayashi
    Laboratory of Plant Nutrition, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    J Exp Bot 55:1441-3. 2004
    Genes whose expression was up-regulated in low boron (B)-acclimated tobacco BY-2 (Nicotiana tabacum L. cv. Bright Yellow 2) cells, which had been selected under a low supply of B, were screened by the cDNA differential subtraction method...
  91. doi In vitro and in vivo photocytotoxicity of boron dipyrromethene derivatives for photodynamic therapy
    Siang Hui Lim
    Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 47500 Subang Jaya, Selangor, Malaysia
    J Med Chem 53:2865-74. 2010
    To understand the effects of substitution patterns on photosensitizing the ability of boron dipyrromethene (BODIPY), two structural variations that either investigate the effectiveness of various iodinated derivatives to maximize the "..
  92. ncbi Intracellular targeting of sodium mercaptoundecahydrododecaborate (BSH) to solid tumors by transferrin-PEG liposomes, for boron neutron-capture therapy (BNCT)
    Kazuo Maruyama
    Department of Pharmaceutics, Teikyo University, Sagamiko, Kanagawa 199 0195, Japan
    J Control Release 98:195-207. 2004
    The successful treatment of cancer by boron neutron-capture therapy (BNCT) requires the selective delivery of relatively high concentration of 10B compounds to malignant tumor tissue...
  93. ncbi Kinetic analysis of boron transport in Chara
    J C Stangoulis
    University of Adelaide, Department of Plant Science, SA, Australia
    Planta 213:142-6. 2001
    ..Esk. R.D. Wood). The advantage of this system is that it is possible to distinguish between membrane transport of boron (B) and complexing of B by plant cell walls...
  94. ncbi Toxicity of boron to rainbow trout: a weight-of-the-evidence assessment
    G Loewengart
    Toxicology and Risk Assessment Associates, Mt Arlington, New Jersey 07856, USA
    Environ Toxicol Chem 20:796-803. 2001
    From the large data set available on the toxicity of boron to aquatic organisms, the toxicity of boron to the early life stages of rainbow trout (Oncorhyncus mykiss) is the seminal issue relative to setting water quality criteria and ..
  95. ncbi Boron binding by a siderophore isolated from marine bacteria associated with the toxic dinoflagellate Gymnodinium catenatum
    Shady A Amin
    Department of Chemistry and Biochemistry, San Diego State University, San Diego, California 92182 1030, USA
    J Am Chem Soc 129:478-9. 2007
  96. ncbi Saccharomyces cerevisiae Bor1p is a boron exporter and a key determinant of boron tolerance
    Junpei Takano
    Biotechnology Research Center, University of Tokyo, Yayoi, Tokyo, Japan
    FEMS Microbiol Lett 267:230-5. 2007
    b>Boron is toxic to living organisms when present in excess. Saccharomyces cerevisiae Bor1p is a plasma membrane protein that decreases the intracellular concentration of boron and confers boron tolerance in yeasts...
  97. ncbi Electrochemical oxidation of benzene on boron-doped diamond electrodes
    Robson T S Oliveira
    GMEME Instituto de Química de São Carlos, Universidade de Sao Paulo, Caixa Postal 780, 13566 590 Sao Carlos, SP, Brazil
    Chemosphere 66:2152-8. 2007
    This work presents an electrochemical investigation of the benzene oxidation process in aqueous solution on boron-doped diamond (BDD) electrodes...
  98. ncbi The effect of pregnancy on renal clearance of boron in humans: a study based on normal dietary intake of boron
    M V Pahl
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, California 92697, USA
    Toxicol Sci 60:252-6. 2001
    b>Boron occurs most frequently in nature as borates and boric acid, never as the free element. Its largest uses are in glass, detergents, and agriculture...
  99. pmc An investigation of boron toxicity in barley using metabolomics
    Ute Roessner
    Australian Centre for Plant Functional Genomics, School of Botany, University of Melbourne, Victoria 3010, Australia
    Plant Physiol 142:1087-101. 2006
    b>Boron (B) is an essential micronutrient that affects plant growth at either deficient or toxic concentrations in soil...
  100. pmc Use of phenylboronic acids to investigate boron function in plants. Possible role of boron in transvacuolar cytoplasmic strands and cell-to-wall adhesion
    Elias Bassil
    Pomology Department, University of California, Davis, California 95616, USA
    Plant Physiol 136:3383-95. 2004
    The only defined physiological role of boron in plants is as a cross-linking molecule involving reversible covalent bonds with cis-diols on either side of borate...
  101. ncbi Boron intake and prostate cancer risk
    Alejandro Gonzalez
    Cancer Prevention Pragram, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Causes Control 18:1131-40. 2007
    Experimental studies suggest that boron may prevent prostate cancer...

Research Grants74

  1. Catalytic C-H Activation and Boronic Acid Synthesis
    Milton Smith; Fiscal Year: 2004
    ..There are presently commercialized sensing applications based on boronic acids and boron compounds have interesting activities for protease inhibition and for treating gliboplastoma via boron neutron ..
  2. Boronated nucleosides for neutron capture therapy of brain tumors
    Werner Tjarks; Fiscal Year: 2010
    ..Therefore, the further development of novel treatment modalities for GBM, such as boron neutron capture therapy (BNCT), remains a pressing task for the health science community in the USA...
  3. TUMOR-TARGETING WITH NEW BORONATED PORPHYRINS
    MARIA DA GRACA VICENTE; Fiscal Year: 2009
    This proposal addresses the need for the development of efficient boron delivery agents for application in a new treatment modality for intractable brain tumors and other malignancies, boron neutron capture therapy (BNCT)...
  4. TUMOR-TARGETING WITH NEW BORONATED PORPHYRINS
    MARIA DA GRACA HENRIQUES VICENTE; Fiscal Year: 2010
    This proposal addresses the need for the development of efficient boron delivery agents for application in a new treatment modality for intractable brain tumors and other malignancies, boron neutron capture therapy (BNCT)...
  5. TUMOR-TARGETING WITH NEW BORONATED PORPHYRINS
    MARIA DA GRACA VICENTE; Fiscal Year: 2006
    ..We propose to synthesize and characterize new non-toxic boron containing porphyrins that selectively localize within tumors and which may be used for boron neutron capture ..
  6. Boronated nucleosides for neutron capture therapy of brain tumors
    Werner Tjarks; Fiscal Year: 2011
    ..Therefore, the further development of novel treatment modalities for GBM, such as boron neutron capture therapy (BNCT), remains a pressing task for the health science community in the USA...
  7. An Epithermal Neutron Source for Cancer Therapy
    MELVIN PIESTRUP; Fiscal Year: 2006
    We propose to develop a commercial neutron source for the treatment of brain and liver cancer based on boron neutron capture therapy (BNCT)...
  8. SUPERHEATED DROP DETECTORS FOR DOSIMETRY IN RADIOTHERAPY
    Ravinder Nath; Fiscal Year: 2001
    ..particle beams and for the spectrometry of neutron fields created at depth in tissue by x-ray, electron, proton or boron neutron capture therapy beams...
  9. Phase I / II Trial for Neutron Capture Therapy
    Matthew Palmer; Fiscal Year: 2002
    ..The starting point will be a volume average brain dose of 7.0 RBE-Gy given in two fractions. Boron-delivery will be through the use of l-p-boronophenylalanine-fructose (BPA-f), 14 grams/meter-squared IV, over 90 ..
  10. A Phase II Trial for Neutron Capture Therapy in Melanoma
    Paul Busse; Fiscal Year: 2003
    ..b>Boron-delivery will be through the use of l-p-boronophenylalanine-fructose (BPA-f), 14 grams/meter-squared IV, over 90 ..
  11. Organotrifluoroborates in Selective Organic Synthesis
    Gary A Molander; Fiscal Year: 2010
    ..as a means to build molecular complexity into the organotrifluoroborates while retaining the valuable carbon-boron bond for further transformations (i.e., using the trifluoroborate as a protected boronic acid)...
  12. Organotrifluoroborates in Selective Organic Synthesis
    Gary A Molander; Fiscal Year: 2010
    ..as a means to build molecular complexity into the organotrifluoroborates while retaining the valuable carbon-boron bond for further transformations (i.e., using the trifluoroborate as a protected boronic acid)...
  13. SYNTHESIS AND EVALUATION OF BORONATED FOLATES FOR BNCT
    Werner Tjarks; Fiscal Year: 2001
    DESCRIPTION: (Applicant's Abstract) The development of boron compounds for the treatment of squamous cell carcinoma of the head and neck (SCCHN) by Boron Neutron Capture Therapy (BNCT) requires the synthesis and evaluation of non-toxic ..
  14. Neutron Microscope for In-Vivo Imaging
    JAY CREMER; Fiscal Year: 2005
    ..or cold neutron microscope that we will address in the proposed program is to provide a new imaging modality in boron neutron capture therapy (BNCT) for the treatment of glioblastomas and anaplastic astrocytomas...
  15. Liposome Delivery of Boron for BNCT
    M Hawthorne; Fiscal Year: 2007
    b>Boron neutron capture therapy (BNCT) is a binary radiation treatment for cancer, which requires the initial selective concentration of the boron-10 isotope within the malignant cells under attack...
  16. Electrophilic Boranes: Directed Hydroboration, Borylation, and Related Reactions
    Edwin Vedejs; Fiscal Year: 2010
    ..The proposed studies will access synthetically important boronates using new procedures for boron activation...
  17. PROGRAM FOR DEVELOPMENT OF BNCT AGENTS
    STEPHEN KAHL; Fiscal Year: 2007
    ..b>Boron neutron capture therapy (BNCT) is a form of targeted radiochemotherapy that has the potential to increase local ..
  18. PROGRAM FOR DEVELOPMENT OF BNCT AGENTS
    STEPHEN KAHL; Fiscal Year: 2004
    ..adapted from applicant's abstract): The long-term goal of this program is the development of tumor seeking boron compounds for use as radiochemotherapeutic agents for boron capture therapy (BNCT) of cancer...