boron

Summary

Summary: A trace element with the atomic symbol B, atomic number 5, and atomic weight 10.81. Boron-10, an isotope of boron, is used as a neutron absorber in BORON NEUTRON CAPTURE THERAPY.

Top Publications

  1. ncbi A bystander effect observed in boron neutron capture therapy: a study of the induction of mutations in the HPRT locus
    Yuko Kinashi
    Research Reactor Institute, Kyoto University, Osaka, Japan
    Int J Radiat Oncol Biol Phys 68:508-14. 2007
  2. pmc Dissecting quantitative trait loci for boron efficiency across multiple environments in Brassica napus
    Zunkang Zhao
    National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, Hubei, China
    PLoS ONE 7:e45215. 2012
  3. ncbi Proliferation, differentiation and gene expression of osteoblasts in boron-containing associated with dexamethasone deliver from mesoporous bioactive glass scaffolds
    Chengtie Wu
    Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, People s Republic of China
    Biomaterials 32:7068-78. 2011
  4. ncbi Can boron and nitrogen co-doping improve oxygen reduction reaction activity of carbon nanotubes?
    Yu Zhao
    Key Laboratory of Mesoscopic Chemistry of MOE and Jiangsu Provincial Lab for NanoTechnology, Institute of Theoretical and Computational Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, 210093 Nanjing, PR China
    J Am Chem Soc 135:1201-4. 2013
  5. pmc Condensin II alleviates DNA damage and is essential for tolerance of boron overload stress in Arabidopsis
    Takuya Sakamoto
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Plant Cell 23:3533-46. 2011
  6. ncbi Arabidopsis boron transporter for xylem loading
    Junpei Takano
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Nature 420:337-40. 2002
  7. ncbi Boron toxicity is alleviated by hydrogen sulfide in cucumber (Cucumis sativus L.) seedlings
    Bao Lan Wang
    State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, The Chinese Academy of Sciences, Beijing 100093, People s Republic of China
    Planta 231:1301-9. 2010
  8. ncbi Structural identification of a bacterial quorum-sensing signal containing boron
    Xin Chen
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    Nature 415:545-9. 2002
  9. pmc Boron stress responsive microRNAs and their targets in barley
    Esma Ozhuner
    Department of Biology, Faculty of Science, Cankiri Karatekin University, Cankiri, Turkey
    PLoS ONE 8:e59543. 2013
  10. pmc The aromatic/arginine selectivity filter of NIP aquaporins plays a critical role in substrate selectivity for silicon, boron, and arsenic
    Namiki Mitani-Ueno
    Institute of Plant Science and Resources, Okayama University, Chuo 2 20 1, Kurashiki 710 0046, Japan
    J Exp Bot 62:4391-8. 2011

Detail Information

Publications296 found, 100 shown here

  1. ncbi A bystander effect observed in boron neutron capture therapy: a study of the induction of mutations in the HPRT locus
    Yuko Kinashi
    Research Reactor Institute, Kyoto University, Osaka, Japan
    Int J Radiat Oncol Biol Phys 68:508-14. 2007
    To investigate bystander mutagenic effects induced by alpha-particles during boron neutron capture therapy, we mixed cells that were electroporated with borocaptate sodium (BSH), which led to the accumulation of (10)B inside the cells, ..
  2. pmc Dissecting quantitative trait loci for boron efficiency across multiple environments in Brassica napus
    Zunkang Zhao
    National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, Hubei, China
    PLoS ONE 7:e45215. 2012
    High yield is the most important goal in crop breeding, and boron (B) is an essential micronutrient for plants. However, B deficiency, leading to yield decreases, is an agricultural problem worldwide...
  3. ncbi Proliferation, differentiation and gene expression of osteoblasts in boron-containing associated with dexamethasone deliver from mesoporous bioactive glass scaffolds
    Chengtie Wu
    Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, People s Republic of China
    Biomaterials 32:7068-78. 2011
    b>Boron is one of the trace elements in the human body which plays an important role in bone growth...
  4. ncbi Can boron and nitrogen co-doping improve oxygen reduction reaction activity of carbon nanotubes?
    Yu Zhao
    Key Laboratory of Mesoscopic Chemistry of MOE and Jiangsu Provincial Lab for NanoTechnology, Institute of Theoretical and Computational Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, 210093 Nanjing, PR China
    J Am Chem Soc 135:1201-4. 2013
    Two kinds of boron and nitrogen co-doped carbon nanotubes (CNTs) dominated by bonded or separated B and N are intentionally prepared, which present distinct oxygen reduction reaction (ORR) performances...
  5. pmc Condensin II alleviates DNA damage and is essential for tolerance of boron overload stress in Arabidopsis
    Takuya Sakamoto
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Plant Cell 23:3533-46. 2011
    Although excess boron (B) is known to negatively affect plant growth, its molecular mechanism of toxicity is unknown. We previously isolated two Arabidopsis thaliana mutants, hypersensitive to excess B (heb1-1 and heb2-1)...
  6. ncbi Arabidopsis boron transporter for xylem loading
    Junpei Takano
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Nature 420:337-40. 2002
    b>Boron deficiency hampers the productivity of 132 crops in more than 80 countries...
  7. ncbi Boron toxicity is alleviated by hydrogen sulfide in cucumber (Cucumis sativus L.) seedlings
    Bao Lan Wang
    State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, The Chinese Academy of Sciences, Beijing 100093, People s Republic of China
    Planta 231:1301-9. 2010
    b>Boron (B) is an essential micronutrient for plants, which when occurs in excess in the growth medium, becomes toxic to plants. Rapid inhibition of root elongation is one of the most distinct symptoms of B toxicity...
  8. ncbi Structural identification of a bacterial quorum-sensing signal containing boron
    Xin Chen
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    Nature 415:545-9. 2002
    ..Furthermore, they indicate a potential biological role for boron, an element required by a number of organisms but for unknown reasons.
  9. pmc Boron stress responsive microRNAs and their targets in barley
    Esma Ozhuner
    Department of Biology, Faculty of Science, Cankiri Karatekin University, Cankiri, Turkey
    PLoS ONE 8:e59543. 2013
    b>Boron stress is an environmental factor affecting plant development and production. Recently, microRNAs (miRNAs) have been found to be involved in several plant processes such as growth regulation and stress responses...
  10. pmc The aromatic/arginine selectivity filter of NIP aquaporins plays a critical role in substrate selectivity for silicon, boron, and arsenic
    Namiki Mitani-Ueno
    Institute of Plant Science and Resources, Okayama University, Chuo 2 20 1, Kurashiki 710 0046, Japan
    J Exp Bot 62:4391-8. 2011
    ..The results reveal that the residue at the H5 position of the ar/R filter of both OsLsi1 and AtNIP5;1 plays a key role in the permeability to Si and B, but there is a relatively low selectivity for arsenite...
  11. ncbi A molecular framework for the inhibition of Arabidopsis root growth in response to boron toxicity
    Felipe Aquea
    Departamento Genética Molecular y Microbiología, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Plant Cell Environ 35:719-34. 2012
    b>Boron is an essential micronutrient for plants and is taken up in the form of boric acid (BA)...
  12. ncbi WRKY6 is involved in the response to boron deficiency in Arabidopsis thaliana
    Ichiro Kasajima
    Biotechnology Research Center, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Physiol Plant 139:80-92. 2010
    b>Boron (B) is one of the essential nutrients for plant growth and reproduction. Transcriptome analyses have identified genes regulated by B deficiency, but their function mostly remains elusive...
  13. ncbi Binary and ternary doping of nitrogen, boron, and phosphorus into carbon for enhancing electrochemical oxygen reduction activity
    Chang Hyuck Choi
    Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 305 701, Republic of Korea
    ACS Nano 6:7084-91. 2012
    ....
  14. ncbi Substituted carborane-appended water-soluble single-wall carbon nanotubes: new approach to boron neutron capture therapy drug delivery
    Zhu Yinghuai
    Institute of Chemical and Engineering Sciences, No 1 Pesek Road, Jurong Island, Singapore 627833
    J Am Chem Soc 127:9875-80. 2005
    ..one of these nanotubes, {([Na(+)][1-Me-2-((CH(2))(4)NH-)-1,2-C(2)B(9)H(10)][OEt])(n)(SWCNT)} (Va), show that the boron atoms are concentrated more in tumors cells than in blood and other organs, making it an attractive nanovehicle ..
  15. pmc Highly boron deficiency-tolerant plants generated by enhanced expression of NIP5;1, a boric acid channel
    Yuichi Kato
    Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Plant Cell Physiol 50:58-66. 2009
    b>Boron (B) is an essential element for plants, and B deficiency is a worldwide agricultural problem. In B-deficient areas, B is often supplied as fertilizer, but excess B can be toxic to both plants and animals...
  16. ncbi Overexpression of the tonoplast aquaporin AtTIP5;1 conferred tolerance to boron toxicity in Arabidopsis
    Yongqi Pang
    State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, China
    J Genet Genomics 37:389-97, 1-2. 2010
    b>Boron (B) toxicity to plants is responsible for low crop productivity in many regions of the world. Here we report a novel and effective means to alleviate the B toxicity to plants under high B circumstance...
  17. ncbi Proteomic alterations of Brassica napus root in response to boron deficiency
    Zhifang Wang
    National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, 430070 Wuhan, China
    Plant Mol Biol 74:265-78. 2010
    b>Boron (B) deficiency is a worldwide problem, and Brassica napus is one of the most sensitive crops to B deficiency...
  18. pmc Efficient C-B bond formation promoted by N-heterocyclic carbenes: synthesis of tertiary and quaternary B-substituted carbons through metal-free catalytic boron conjugate additions to cyclic and acyclic alpha,beta-unsaturated carbonyls
    Kang sang Lee
    Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA
    J Am Chem Soc 131:7253-5. 2009
    ..Representative functionalization of the resulting boron enolates demonstrates the strong influence of the Lewis acidic B atom of the beta-boronate.
  19. ncbi Quantitative imaging and microlocalization of boron-10 in brain tumors and infiltrating tumor cells by SIMS ion microscopy: relevance to neutron capture therapy
    D R Smith
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA
    Cancer Res 61:8179-87. 2001
    b>Boron neutron capture therapy (BNCT) is dependent on the selective accumulation of boron-10 in tumor cells relative to the contiguous normal cells...
  20. ncbi Intracellular targeting of sodium mercaptoundecahydrododecaborate (BSH) to solid tumors by transferrin-PEG liposomes, for boron neutron-capture therapy (BNCT)
    Kazuo Maruyama
    Department of Pharmaceutics, Teikyo University, Sagamiko, Kanagawa 199 0195, Japan
    J Control Release 98:195-207. 2004
    The successful treatment of cancer by boron neutron-capture therapy (BNCT) requires the selective delivery of relatively high concentration of 10B compounds to malignant tumor tissue...
  21. pmc Polar localization and degradation of Arabidopsis boron transporters through distinct trafficking pathways
    Junpei Takano
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    Proc Natl Acad Sci U S A 107:5220-5. 2010
    b>Boron (B) is essential for plant growth but is toxic when present in excess...
  22. ncbi iTRAQ protein profile analysis of Citrus sinensis roots in response to long-term boron-deficiency
    Lin Tong Yang
    College of Resources and Environmental Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China Institute of Horticultural Plant Physiology, Biochemistry and Molecular Biology, Fujian Agriculture and Forestry University, Fuzhou 350002, China
    J Proteomics 93:179-206. 2013
    Seedlings of Citrus sinensis were fertilized with boron (B)-deficient (0μM H3BO3) or -sufficient (10μM H3BO3) nutrient solution for 15weeks...
  23. ncbi Differential expression of three BOR1 genes corresponding to different genomes in response to boron conditions in hexaploid wheat (Triticum aestivum L.)
    Sumana Leaungthitikanchana
    Graduate School of Agricultural and Life Sciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo, 113 8657 Japan
    Plant Cell Physiol 54:1056-63. 2013
    b>Boron (B) is an essential micronutrient for plants. Efflux-type B transporters, BORs, have been identified in Arabidopsis thaliana and rice...
  24. ncbi Microbial diversity of boron-rich volcanic hot springs of St. Lucia, Lesser Antilles
    Lisa M Stout
    Department of Geology and Geophysics, Yale University, New Haven, CT 06520, USA
    FEMS Microbiol Ecol 70:402-12. 2009
    ..present an extreme environment due to high temperatures, low pH values, and high concentrations of sulfate and boron. St...
  25. ncbi Transcriptome-wide identification of R2R3-MYB transcription factors in barley with their boron responsive expression analysis
    Huseyin Tombuloglu
    Department of Biology, Faculty of Arts and Science, Fatih University, Buyukcekmece, Istanbul, Turkey
    Mol Genet Genomics 288:141-55. 2013
    ..the identification of barley R2R3-MYB TFs including their expression analysis in tissues under control and Boron (B) toxic conditions...
  26. ncbi Boron analysis and boron imaging in biological materials for Boron Neutron Capture Therapy (BNCT)
    Andrea Wittig
    Department of Radiation Oncology, University Duisburg Essen, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Crit Rev Oncol Hematol 68:66-90. 2008
    b>Boron Neutron Capture Therapy (BNCT) is based on the ability of the stable isotope 10B to capture neutrons, which leads to a nuclear reaction producing an alpha- and a 7Li-particle, both having a high biological effectiveness and a very ..
  27. ncbi Two-dimensional boron monolayer sheets
    Xiaojun Wu
    CAS Key Lab of Materials for Energy Conversion, Department of Materials Science and Engineering and Hefei National Lab for Physical Materials at Microscale, University of Science and Technology of China, Hefei, Anhui 230026, China
    ACS Nano 6:7443-53. 2012
    b>Boron, a nearest-neighbor of carbon, is possibly the second element that can possess free-standing flat monolayer structures, evidenced by recent successful synthesis of single-walled and multiwalled boron nanotubes (MWBNTs)...
  28. ncbi Boron deficiency results in induction of pathogenesis-related proteins from the PR-10 family during the legume-rhizobia interaction
    María Reguera
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, Darwin 2, 28049 Madrid, Spain
    J Plant Physiol 167:625-32. 2010
    b>Boron (B) deficiency has a strong effect on molecular and cellular plant-bacteria interactions during the development of the legume-rhizobia symbiosis, leading to reduced infection and early necrosis of nodules, resembling a pathogenic-..
  29. pmc Metal-free catalytic enantioselective C-B bond formation: (pinacolato)boron conjugate additions to α,β-unsaturated ketones, esters, Weinreb amides, and aldehydes promoted by chiral N-heterocyclic carbenes
    Hao Wu
    Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, United States
    J Am Chem Soc 134:8277-85. 2012
    The first broadly applicable metal-free enantioselective method for boron conjugate addition (BCA) to α,β-unsaturated carbonyls is presented. The C-B bond forming reactions are promoted in the presence of 2.5-7...
  30. ncbi In vivo evolutionary engineering of a boron-resistant bacterium: Bacillus boroniphilus
    Mustafa Sen
    Department of Molecular Biology and Genetics, Faculty of Science and Letters, Istanbul Technical University, Istanbul, Maslak, 34469, Turkey
    Antonie Van Leeuwenhoek 99:825-35. 2011
    b>Boron is an industrially and biologically important element. However, the mechanisms of boron tolerance and its transport in bacteria and many other living systems are still not clearly understood...
  31. pmc Cell-type specificity of the expression of Os BOR1, a rice efflux boron transporter gene, is regulated in response to boron availability for efficient boron uptake and xylem loading
    Yuko Nakagawa
    Biotechnology Research Center, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Plant Cell 19:2624-35. 2007
    We describe a boron (B) transporter, Os BOR1, in rice (Oryza sativa)...
  32. pmc Boron transport in plants: co-ordinated regulation of transporters
    Kyoko Miwa
    Creative Research Initiative Sousei, Hokkaido University, Kita ku, Sapporo, Hokkaido 001 0021, Japan
    Ann Bot 105:1103-8. 2010
    The essentiality of boron (B) for plant growth was established > 85 years ago...
  33. ncbi Boron neutron capture therapy for glioblastoma multiforme: clinical studies in Sweden
    Jacek Capala
    Studsvik Medical AB, Nykoping, Sweden
    J Neurooncol 62:135-44. 2003
    A boron neutron capture therapy (BNCT) facility has been constructed at Studsvik, Sweden. It includes two filter/moderator configurations...
  34. ncbi VvBOR1, the grapevine ortholog of AtBOR1, encodes an efflux boron transporter that is differentially expressed throughout reproductive development of Vitis vinifera L
    Ramón Perez-Castro
    Instituto de Biologia Vegetal y Biotecnologia, Universidad de Talca, Talca, Chile
    Plant Cell Physiol 53:485-94. 2012
    b>Boron (B) is an essential micronutrient for normal development of roots, shoots and reproductive tissues in plants...
  35. pmc Antagonistic actions of boron against inhibitory effects of aluminum toxicity on growth, CO2 assimilation, ribulose-1,5-bisphosphate carboxylase/oxygenase, and photosynthetic electron transport probed by the JIP-test, of Citrus grandis seedlings
    Huan Xin Jiang
    Institute of Horticultural Plant Physiology, Biochemistry and Molecular Biology, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China
    BMC Plant Biol 9:102. 2009
    Little information is available on the amelioration of boron (B) on aluminum (Al)-induced photosynthesis inhibition. Sour pummelo (Citrus grandis) seedlings were irrigated for 18 weeks with nutrient solution containing 4 B levels (2...
  36. ncbi Boron neutron capture therapy (BNCT) for glioblastoma multiforme: a phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA)
    Roger Henriksson
    Department of Radiation Sciences and Oncology, Umea University, Umea, Sweden
    Radiother Oncol 88:183-91. 2008
    To evaluate the efficacy and safety of boron neutron capture therapy (BNCT) for glioblastoma multiforme (GBM) using a novel protocol for the boronophenylalanine-fructose (BPA-F) infusion.
  37. ncbi The analysis of Lupinus albus root proteome revealed cytoskeleton altered features due to long-term boron deficiency
    M Alves
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Av da Republica, 2780 157 Oeiras, Portugal
    J Proteomics 74:1351-63. 2011
    b>Boron (B) deficiency greatly limits plants' growth and development. Since the root is the organ that first senses the deficiency, we have analyzed the adaptive responses of Lupinus albus roots to long-term B deficiency...
  38. ncbi Roles of BOR1, DUR3, and FPS1 in boron transport and tolerance in Saccharomyces cerevisiae
    Akira Nozawa
    Precursory Research for Embryonic Science and Technology, Saitama, Japan
    FEMS Microbiol Lett 262:216-22. 2006
    The roles of three membrane proteins, BOR1, DUR3, and FPS1, in boron (B) transport in yeast were examined...
  39. pmc Identification of a novel system for boron transport: Atr1 is a main boron exporter in yeast
    Alaattin Kaya
    Department of Molecular Biology and Genetics, Izmir Institute of Technology, 35430 Urla, Izmir, Turkey
    Mol Cell Biol 29:3665-74. 2009
    b>Boron is a micronutrient in plants and animals, but its specific roles in cellular processes are not known...
  40. ncbi Properties of hybridized DNA arrays on single-crystalline undoped and boron-doped (100) diamonds studied by atomic force microscopy in electrolytes
    Bohuslav Rezek
    Diamond Research Center, AIST, Central 2, Tsukuba 305 8568, Japan
    Langmuir 23:7626-33. 2007
    Properties of hybridized deoxyribonucleic acid (DNA) arrays on single-crystalline undoped and boron-doped diamonds are studied at the microscopic level by atomic force microscopy (AFM) in buffered electrolytic solutions...
  41. ncbi High-level exposure to lithium, boron, cesium, and arsenic via drinking water in the Andes of northern Argentina
    Gabriela Concha
    Division of Toxicology, Swedish National Food Administration, Box 622, S 751 26 Uppsala, Sweden
    Environ Sci Technol 44:6875-80. 2010
    ..high concentrations of lithium (highest 1000 microg/L), cesium (320 microg/L), rubidium (47 microg/L), and boron (5950 microg/L)...
  42. ncbi Physiological roles and transport mechanisms of boron: perspectives from plants
    Mayuki Tanaka
    Biotechnology Research Center, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo, Japan
    Pflugers Arch 456:671-7. 2008
    b>Boron, an orphan of the periodic table of the elements, is unique not only in its chemical properties but also in its roles in biology. Its requirement in plants was described more than 80 years ago...
  43. pmc High boron-induced ubiquitination regulates vacuolar sorting of the BOR1 borate transporter in Arabidopsis thaliana
    Koji Kasai
    Biotechnology Research Center, University of Tokyo, Tokyo 113 8657, Japan
    J Biol Chem 286:6175-83. 2011
    b>Boron homeostasis is important for plants, as boron is essential but is toxic in excess...
  44. pmc Increased abundance of proteins involved in phytosiderophore production in boron-tolerant barley
    John Patterson
    Australian Centre for Plant Functional Genomics, School of Botany, University of Melbourne, Victoria, Australia
    Plant Physiol 144:1612-31. 2007
    b>Boron (B) phytotoxicity affects cereal-growing regions worldwide. Although B-tolerant barley (Hordeum vulgare) germplasm is available, molecules responsible for this tolerance mechanism have not been defined...
  45. ncbi Why boron?
    Luis Bolaños
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Plant Physiol Biochem 42:907-12. 2004
    It is now more than 80 years since boron was convincingly demonstrated to be essential for normal growth of higher plants. However, its biochemical role is not well understood at the moment...
  46. ncbi An expeditious synthesis of DPD and boron binding studies
    Martin F Semmelhack
    Departments of Chemistry and Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Org Lett 7:569-72. 2005
    ..reaction: see text]..
  47. pmc Boron toxicity tolerance in barley through reduced expression of the multifunctional aquaporin HvNIP2;1
    Thorsten Schnurbusch
    Australian Centre for Plant Functional Genomics, University of Adelaide, Waite Campus, Urrbrae, South Australia 5064, Australia
    Plant Physiol 153:1706-15. 2010
    b>Boron (B) toxicity is a significant limitation to cereal crop production in a number of regions worldwide...
  48. pmc The Arabidopsis major intrinsic protein NIP5;1 is essential for efficient boron uptake and plant development under boron limitation
    Junpei Takano
    Biotechnology Research Center, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Plant Cell 18:1498-509. 2006
    b>Boron (B) is essential in plants but often present at low concentrations in the environment...
  49. ncbi Inhibitory effect of boron against Botrytis cinerea on table grapes and its possible mechanisms of action
    Guozheng Qin
    Research Center for Molecular and Developmental Biology, Institute of Botany, Chinese Academy of Sciences, Beijing, China
    Int J Food Microbiol 138:145-50. 2010
    b>Boron, an essential plant micronutrient, was effective in the form of potassium tetraborate for control of postharvest gray mold caused by Botrytis cinerea on table grapes stored at room temperature or at 0 degrees C...
  50. pmc Influence of leaf tolerance mechanisms and rain on boron toxicity in barley and wheat
    Rob Reid
    School of Earth and Environmental Sciences, University of Adelaide, Adelaide 5005, Australia
    Plant Physiol 151:413-20. 2009
    b>Boron (B) toxicity is common in many areas of the world. Plant tolerance to high B varies widely and has previously been attributed to reduced uptake of B, most commonly as a result of B efflux from roots...
  51. ncbi Avidin self-associates with boric acid gel suspensions: an affinity boron carrier that might be developed for boron neutron-capture therapy
    Bennie J Bench
    Department of Physical Sciences, Southeastern Oklahoma State University, Durant, OK 74701, USA
    J Colloid Interface Sci 270:315-20. 2004
    ..gel polymer, and avidin-coated gel particles in the micrometer and submicrometer size ranges are of interest for boron neutron-capture therapy (BNCT), which is neutron-induced fission of boron-10 to produce intense alpha radiation ..
  52. ncbi Trace voltammetric detection of serotonin at carbon electrodes: comparison of glassy carbon, boron doped diamond and carbon nanotube network electrodes
    Aleix G Güell
    Department of Chemistry, University of Warwick, Coventry, UK CV4 7AL
    Phys Chem Chem Phys 12:10108-14. 2010
    The characteristics of three different carbon electrodes, glassy carbon (GC), oxygen-terminated polycrystalline boron-doped diamond (pBDD) and "pristine" carbon nanotube networks (CNTN) as voltammetric sensors for detection of the ..
  53. ncbi Interaction between boron and aluminum and their effects on phenolic metabolism of Linum usitatissimum L. roots
    Maryam Dahajipour Heidarabadi
    Department of Plant Biology, Faculty of Biological Science, Tarbiat Modares University TMU, POB 14115 154, Tehran, Iran
    Plant Physiol Biochem 49:1377-83. 2011
    ..Inhibition of root growth has been considered as a sensitive marker of aluminum toxicity and the best indicator of boron deficiency as well...
  54. ncbi Novel boron-containing, nonclassical antifolates: synthesis and preliminary biological and structural evaluation
    Robert C Reynolds
    Drug Discovery Division, Southern Research Institute, Birmingham, Alabama 35205, USA
    J Med Chem 50:3283-9. 2007
    Two boron-containing, ortho-icosahedral carborane lipophilic antifolates were synthesized, and the crystal structures of their ternary complexes with human dihydrofolate reductase (DHFR) and dihydronicotinamide adenine dinucleotide ..
  55. ncbi Production of no-carrier-added 64Cu from zinc metal irradiated under boron shielding
    K R Zinn
    University of Missouri Research Reactor, Columbia 65211
    Cancer 73:774-8. 1994
    ..This work was designed to develop a viable method to produce and purify 64Cu, which has high specific activity, for positron emission tomography...
  56. ncbi Efficient NIR-light emission from solid-state complexes of boron difluoride with 2'-hydroxychalcone derivatives
    Anthony D'Aléo
    Aix Marseille Universite, CNRS, CINaM UMR, Campus de Luminy, France
    Chemistry 18:12764-72. 2012
    This article describes a series of nine complexes of boron difluoride with 2'-hydroxychacone derivatives. These dyes were synthesized very simply and exhibited intense NIR emission in the solid state...
  57. ncbi Exogenous nitric oxide donor protects Artemisia annua from oxidative stress generated by boron and aluminium toxicity
    Tariq Aftab
    Division of Germplasm Evaluation, National Bureau of Plant Genetic Resources, Pusa Campus, New Delhi 110012, India
    Ecotoxicol Environ Saf 80:60-8. 2012
    ..Here we report the effects of boron (B) and aluminium (Al) contamination in soil, carried out with or without application of exogenous SNP (NO donor), ..
  58. ncbi Boron nutrition of cultured tobacco BY-2 cells. VI. Calcium is involved in early responses to boron deprivation
    Taichi Koshiba
    Graduate School of Agriculture, Kyoto University, Kyoto, 606 8502 Japan
    Plant Cell Physiol 51:323-7. 2010
    b>Boron (B) deprivation induces various responses in plant cells, some of which can be observed very early. However, it has been unknown what kind of signal is generated by the stress...
  59. ncbi Direct electrochemistry of Shewanella loihica PV-4 on gold nanoparticles-modified boron-doped diamond electrodes fabricated by layer-by-layer technique
    Wenguo Wu
    State Key Laboratory of Bioelectronics, Biological Science and Medical Engineering Department, Southeast University, Nanjing 210096, P R China
    J Nanosci Nanotechnol 12:3903-8. 2012
    ..Au nanoparticles (AuNPs)-modified Boron-Doped Diamond (BDD) electrodes are fabricated by layer-by-layer (LBL) self-assembly technique and used for the ..
  60. ncbi Simultaneous voltammetric determination of synthetic colorants in food using a cathodically pretreated boron-doped diamond electrode
    Roberta A Medeiros
    Departamento de Quimica, Universidade Federal de Sao Carlos, C P 676, São Carlos SP 13560 970, Brazil
    Talanta 97:291-7. 2012
    Differential pulse voltammetry (DPV) and a cathodically pretreated boron-doped diamond (BDD) electrode were used to simultaneously determine two pairs of synthetic food colorants commonly found mixed in food products: tartrazine (TT) and ..
  61. ncbi Use of 'split waves' for the measurement of electrocatalytic kinetics: methyl viologen mediated oxygen reduction on a boron-doped diamond electrode
    Qianqi Lin
    Department of Chemistry, Physical and Theoretical Chemistry Laboratory, Oxford University, South Parks Road, Oxford OX1 3QZ, UK
    Phys Chem Chem Phys 15:7760-7. 2013
    ..The investigation is facilitated through the use of a boron-doped diamond electrode, allowing the catalytic response to be clearly delineated from that of the direct oxygen ..
  62. ncbi Interrupted zeolite LTA and ATN-type boron imidazolate frameworks
    Hai Xia Zhang
    State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, PR China
    J Am Chem Soc 133:11884-7. 2011
    ..The first interrupted Zeolite A with 3-connected network has been experimentally realized here by a boron imidazolate (im) framework material (BIF-20) with 3-coordinate BH(mim)(3)(-) building units...
  63. ncbi Review: mechanisms for boron deficiency-mediated changes in plant water relations
    Monika A Wimmer
    Institute of Crop Science and Resource Conservation, Department of Plant Nutrition, University of Bonn, Karlrobert Kreiten Strasse 13, 53115 Bonn, Germany
    Plant Sci 203:25-32. 2013
    b>Boron (B) is an essential microelement for plants and is constantly needed throughout the plant life due to its function as a structural element of the plant cell wall...
  64. ncbi The physiological effects of dietary boron
    Tara A Devirian
    Department of Nutrition, University of Massachusetts, Amherst 01003, USA
    Crit Rev Food Sci Nutr 43:219-31. 2003
    b>Boron may be an essential nutrient for animals and humans...
  65. ncbi In situ DNA oxidative damage by electrochemically generated hydroxyl free radicals on a boron-doped diamond electrode
    S Carlos B Oliveira
    Departamento de Quimica, Faculdade de Ciencias e Tecnologia, Universidade de Coimbra, Coimbra, Portugal
    Langmuir 28:4896-901. 2012
    ..DNA oxidative damage by electrochemically generated hydroxyl free radicals has been directly demonstrated on a boron-doped diamond electrode...
  66. ncbi Borate cross-linked/total rhamnogalacturonan II ratio in cell walls for the biochemical diagnosis of boron deficiency in hydroponically grown pumpkin
    Toshiro Matsunaga
    National Agricultural Research Center, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan
    Anal Sci 22:1125-7. 2006
    b>Boron (B) is an essential micronutrient for vascular plants. The function of B has been demonstrated to cross-link monomeric rhamnogalacturonan II (mRG-II) to form dimeric RG-II-borate (dRG-II-B), and thus to stabilize plant cell walls...
  67. pmc Boron stress activates the general amino acid control mechanism and inhibits protein synthesis
    Irem Uluisik
    Izmir Institute of Technology, Department of Molecular Biology and Genetics, Izmir, Turkey
    PLoS ONE 6:e27772. 2011
    b>Boron is an essential micronutrient for plants, and it is beneficial for animals. However, at high concentrations boron is toxic to cells although the mechanism of this toxicity is not known...
  68. pmc Formation of rhamnogalacturonan II-borate dimer in pectin determines cell wall thickness of pumpkin tissue
    T Ishii
    Forestry and Forest Products Research Institute, P O Box 16, Tsukuba Norin Kenkyu Danchinai, Ibaraki 305 8687, Japan
    Plant Physiol 126:1698-705. 2001
    b>Boron (B) deficiency results in inhibition of pumpkin (Cucurbia moschata Duchesne) growth that is accompanied by swelling of the cell walls...
  69. ncbi Boron uptake in normal melanocytes and melanoma cells and boron biodistribution study in mice bearing B16F10 melanoma for boron neutron capture therapy
    Fernanda Faião-Flores
    Laboratory of Biochemistry and Biophysics, Butantan Institute, 1500 Vital Brasil Avenue, Sao Paulo, SP 05503 900, Brazil
    Radiat Environ Biophys 51:319-29. 2012
    Information on (10)B distribution in normal tissues is crucial to any further development of boron neutron capture therapy (BNCT)...
  70. ncbi Boron nutrition of cultured tobacco BY-2 cells. III. Characterization of the boron-rhamnogalacturonan II complex in cells acclimated to low levels of boron
    T Matoh
    Division of Applied Life Sciences, Faculty of Agriculture, Kyoto University, Japan
    Plant Cell Physiol 41:363-6. 2000
    ..BY-2 which could propagate at the same rate as the parent cells (1 mg B liter(-1)) under a lower level of boron (0.01 mg B liter(-1)) were obtained. The selected cells had swollen cell walls...
  71. ncbi Selectively induced death of macrophages in the synovial lining of murine knee joints using 10B-liposomes and boron neutron capture synovectomy
    Peter L E M van Lent
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Radiat Biol 85:860-71. 2009
    ..whether macrophages in the synovial lining can be selectively eliminated by local administration of an improved boron-10 ((10)B) containing liposome formulation combined with neutron irradiation (boron neutron capture synovectomy [..
  72. ncbi Selection of salt and boron tolerant selenium hyperaccumulator Stanleya pinnata genotypes and characterization of Se phytoremediation from agricultural drainage sediments
    John L Freeman
    Agricultural Research Service, US Department of Agriculture, Parlier, California 93648, United States
    Environ Sci Technol 45:9703-10. 2011
    Genetic variation in salt (Na(2)SO(4), NaCl) and boron (B) tolerance among four ecotypes of the selenium (Se) hyperaccumulator Stanleya pinnata (Pursh) Britton was utilized to select tolerant genotypes capable of phytoremediating Se from ..
  73. ncbi Boron concentrations in milk from mothers of full-term and premature infants
    Curtiss D Hunt
    US Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND, USA
    Am J Clin Nutr 80:1327-33. 2004
    b>Boron is a bioactive element that satisfies several of the criteria for essentiality in humans.
  74. ncbi In vitro induction of matrix metalloproteinase-2 and matrix metalloproteinase-9 expression in keratinocytes by boron and manganese
    Nathalie Chebassier
    Department of Dermatology, INSERM U463, CHU Hotel Dieu, Nantes, France
    Exp Dermatol 13:484-90. 2004
    ..Some thermal waters are rich in trace elements such as boron and manganese...
  75. ncbi Assessment of the potential of a boron-fructose additive in counteracting the toxic effect of Fusarium mycotoxins
    Ionelia Taranu
    INCDBNA, National Institute of Research and Development for Biology and Animal Nutrition, 1, Calea Bucuresti, 077015 Balotesti, Romania
    Br J Nutr 106:398-407. 2011
    ..However, consumption of CFrB did not counteract the effect of mycotoxins on biochemistry parameters, and increased plasma IgM and IgG of contaminated pigs...
  76. ncbi Assessment of the results from the phase I/II boron neutron capture therapy trials at the Brookhaven National Laboratory from a clinician's point of view
    Aidnag Z Diaz
    Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Neurooncol 62:101-9. 2003
    b>Boron neutron capture therapy (BNCT) represents a promising modality for a relatively selective radiation dose delivery to the tumor tissue...
  77. ncbi Degradation of Acid Orange 7 by electrochemically generated (*)OH radicals in acidic aqueous medium using a boron-doped diamond or platinum anode: a mechanistic study
    Samiha Hammami
    Universite Paris Est, Laboratoire des Géomatériaux et Géologie de l Ingénieur, Bat IFI, 5 Boulevard Descartes, 77454 Marne la Vallee Cedex 2, France
    Chemosphere 73:678-84. 2008
    ..0 by electro-Fenton process using Pt or boron-doped diamond (BDD) anode was reported...
  78. pmc Enantioselective synthesis of homoallylic amines through reactions of (pinacolato)allylborons with aryl-, heteroaryl-, alkyl-, or alkene-substituted aldimines catalyzed by chiral C1-symmetric NHC-Cu complexes
    Erika M Vieira
    Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, United States
    J Am Chem Soc 133:3332-5. 2011
    ..5:1.5 enantiomeric ratio and are amenable to gram-scale operations. A mechanistic model accounting for the observed selectivity levels and trends is proposed...
  79. ncbi Identification of boron transporter genes likely to be responsible for tolerance to boron toxicity in wheat and barley
    Rob Reid
    School of Earth and Environmental Sciences, University of Adelaide, Adelaide 5005, Australia
    Plant Cell Physiol 48:1673-8. 2007
    Tolerance to boron (B) toxicity in cereals is known to be associated with reduced tissue accumulation of B...
  80. ncbi Palladium-catalyzed, stereoselective, cyclizative alkenylboration of carbon-carbon double bonds through activation of a boron-chlorine bond
    Masaki Daini
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Kyoto 615 8510, Japan
    J Am Chem Soc 133:4758-61. 2011
    ..Cross-coupling of the resultant products with aryl iodides proceeds with retention of configuration at the boron-bound secondary carbon atom.
  81. ncbi Boron neutron capture therapy of brain tumors: clinical trials at the finnish facility using boronophenylalanine
    Heikki Joensuu
    Department of Oncology, University of Helsinki, Finland
    J Neurooncol 62:123-34. 2003
    Two clinical trials are currently running at the Finnish dedicated boron neutron capture therapy (BNCT) facility...
  82. ncbi Effects of boron and calcium supplementation on mechanical properties of bone in rats
    Mohammad Reza Naghii
    Department of Nutrition, Faculty of Health, Baqiyatallah a s University of Medical Sciences, Tehran, Iran
    Biofactors 28:195-201. 2006
    The objective of this study was to consider the effects of boron (B) and calcium (Ca) supplementation on mechanical properties of bone tissues and mineral content of the selected bones in rats.
  83. pmc Boron-dependent degradation of NIP5;1 mRNA for acclimation to excess boron conditions in Arabidopsis
    Mayuki Tanaka
    Graduate School of Agricultural and Life Science, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Plant Cell 23:3547-59. 2011
    b>Boron (B) is an essential plant micronutrient that is toxic at higher levels. NIP5;1 is a boric acid channel required for B uptake and growth under B deficiency...
  84. ncbi Boron concentrations in milk from mothers of exclusively breast-fed healthy full-term infants are stable during the first four months of lactation
    Curtiss D Hunt
    U S Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND, USA
    J Nutr 135:2383-6. 2005
    Because boron is a bioactive element that satisfies several of the criteria for essentiality in humans, the aim of the present work was to determine the profile of boron metabolism in human milk during the first 4 mo of lactation...
  85. ncbi Boron and fish oil have different beneficial effects on strength and trabecular microarchitecture of bone
    Forrest H Nielsen
    US Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, 2420 2nd Avenue North, Stop 9034, Grand Forks, ND 58202 9034, USA
    J Trace Elem Med Biol 23:195-203. 2009
    An experiment was performed to determine whether boron deprivation would adversely affect vertebra (trabecular) bone microarchitecture, and whether any adverse effect would be modified by dietary fatty acid composition...
  86. pmc Germanium does not substitute for boron in cross-linking of rhamnogalacturonan II in pumpkin cell walls
    Tadashi Ishii
    National Agricultural Research Center for Kyushu Okinawa Region, Nishigoshi, Kumamoto 861 1192, Japan
    Plant Physiol 130:1967-73. 2002
    b>Boron (B)-deficient pumpkin (Cucurbita moschata Duchesne) plants exhibit reduced growth, and their tissues are brittle...
  87. ncbi Analysis of boron content in frequently consumed foods in Korea
    Mi Kyeong Choi
    Department of Human Nutrition and Food Science, Chungwoon University, Chungnam 350 701, South Korea
    Biol Trace Elem Res 126:13-26. 2008
    This study analyzed boron content in commonly consumed foods by Koreans. Boron content was analyzed on 299 different foods using inductively coupled plasma atomic emission spectroscopy...
  88. ncbi Evaluation of the genotoxic effects of the boron neutron capture reaction in human melanoma cells using the cytokinesis block micronucleus assay
    N G Oliveira
    Department of Genetics, Faculty of Medical Sciences, New University of Lisbon, Portugal
    Mutagenesis 16:369-75. 2001
    The present work reports on the genotoxicity of the boron neutron capture (BNC) reaction in human metastatic melanoma cells (A2058) assessed by the cytokinesis block micronucleus assay (CBMN) using p-borono-L-phenylalanine (BPA) as the ..
  89. ncbi Boron and other elements in sporophores of ectomycorrhizal and saprotrophic fungi
    Anu Lavola
    University of Eastern Finland, School of Forest Sciences, P O Box 111, 80101 Joensuu, Finland
    Mycorrhiza 21:155-65. 2011
    Fungi are usually thought not to have a boron (B) requirement. It is not known if mycorrhizas take up B from low concentrations that are common in forest soils, as fungi might also immobilise B...
  90. ncbi Morphology and oxidative physiology of boron-deficient mulberry plants
    Rajesh Kumar Tewari
    Department of Botany, University of Lucknow, Lucknow 226007, India
    Tree Physiol 30:68-77. 2010
    ..11.1.11) were increased in B-deficient leaves. The activities of SOD and POD were decreased in B-supraoptimal plants. The results suggest that B deficiency aggravates oxidative stress through enhanced generation of ROS in mulberry plants...
  91. ncbi Probing properties of boron alpha-tubes by Ab Initio calculations
    Abhishek K Singh
    Department of Mechanical Engineering and Materials Science and Department of Chemistry, Rice University, Houston, Texas 77005, USA
    Nano Lett 8:1314-7. 2008
    We investigate the properties of nanotubes obtained from recently described boron alpha-sheet, using density functional theory. Computations confirm their high stability and identify mechanical stiffness parameters...
  92. ncbi Involvement of auxin and CKs in boron deficiency induced changes in apical dominance of pea plants (Pisum sativum L.)
    Guoying Wang
    Department of Plant Nutrition, China Agricultural University, 100094 Beijing, China
    J Plant Physiol 163:591-600. 2006
    It has previously been shown that boron (B) deficiency inhibits growth of the plant apex, which consequently results in a relatively weak apical dominance, and a subsequent sprouting of lateral buds...
  93. ncbi Salt stress aggravates boron toxicity symptoms in banana leaves by impairing guttation
    O R Shapira
    The Robert H Smith Institute of Plant Sciences and Genetics in Agriculture, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Plant Cell Environ 36:275-87. 2013
    b>Boron (B) is known to accumulate in the leaf margins of different plant species, arguably a passive consequence of enhanced transpiration at the ends of the vascular system...
  94. pmc Biological evaluation of boronated unnatural amino acids as new boron carriers
    G W Kabalka
    Departments of Radiology and Chemistry, The University of Tennessee, Knoxville, TN, USA
    Appl Radiat Isot 67:S374-9. 2009
    There is a pressing need for new and more efficient boron delivery agents to tumor cells for use in boron neutron capture therapy (BNCT)...
  95. ncbi Dose and time dependent apoptotic response in a human melanoma cell line exposed to accelerated boron ions at four different LET
    A E Meijer
    Department of Oncology Pathology, Division of Medical Radiation Physics, Karolinska Institutet, Stockholm, Sweden
    Int J Radiat Biol 81:261-72. 2005
    ..LET), dose and time on the induction of apoptosis in a human melanoma cell line exposed to accelerated light boron ((10)B) ions and photons...
  96. ncbi Chimaereicella boritolerans sp. nov., a boron-tolerant and alkaliphilic bacterium of the family Flavobacteriaceae isolated from soil
    Iftikhar Ahmed
    Biotechnology Research Center, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Int J Syst Evol Microbiol 57:986-92. 2007
    A non-motile, Gram-negative, boron-tolerant and alkaliphilic bacterium was isolated from soil of the Hisarcik area in the Kutahya Province of Turkey that was naturally high in boron minerals...
  97. pmc Enhanced growth and osteogenic differentiation of human osteoblast-like cells on boron-doped nanocrystalline diamond thin films
    Lubica Grausova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    PLoS ONE 6:e20943. 2011
    ..the NCD films were deposited on silicon substrates by a microwave plasma-enhanced CVD process and their boron doping was achieved by adding trimethylboron to the CH(4):H(2) gas mixture, the B∶C ratio was 133, 1000 and 6700 ..
  98. ncbi A serendipitous phosphonocarboxylate complex of boron: when vessel becomes reagent
    Katarzyna M Błazewska
    Department of Chemistry, University of Southern California, Los Angeles, CA 90089 0744, USA
    Chem Commun (Camb) 47:6395-7. 2011
    ..drug minodronate (4) in contact with borosilicate glassware reversibly forms an isolable dimer complex of boron, as revealed by the X-ray crystallographic structure of the (R,R/S,S) complex and supported by NMR and HRMS data.
  99. ncbi Boron deficiency and transcript level changes
    Juan J Camacho-Cristóbal
    Departamento de Fisiologia, Anatomía y Biología Celular, Universidad Pablo de Olavide, E 41013 Sevilla, Spain
    Plant Sci 181:85-9. 2011
    b>Boron (B) is an essential element for plant growth whose deficiency causes an alteration in the expression of a wide range of genes involved in several physiological processes...
  100. ncbi Amperometric biosensor based on tyrosinase immobilized on a boron-doped diamond electrode
    Yan Li Zhou
    Laboratory of Photoelectro Chemistry, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Zhong Guan Cun, Haidian District, Beijing 100080, People s Republic of China
    Biosens Bioelectron 22:822-8. 2007
    A novel method has been developed to immobilize tyrosinase onto the surface of boron-doped diamond (BDD) electrode...
  101. ncbi The effects of boron administration on plasma leptin and lactate levels in ovariectomized rats which had acute swimming exercise
    Zubeyde Yazici
    Department of Physical Education and Sports Sciences, Selcuk University, Konya Turkey, Turkey
    Neuro Endocrinol Lett 29:173-7. 2008
    The aim of this study was to investigate the effects of intraperitoneal (IP) boron administration on leptin and lactate levels in swimming exercise in ovariectomized rats.

Research Grants64

  1. Ultrananocrystalline Diamond Microarray Biosensor for Neurochemical Detection
    Prabhu U Arumugam; Fiscal Year: 2012
    ..We propose development of the next generation electrode material, boron-doped ultrananocrystalline diamond (BD-UNCD) that offers superior sensitivity and specificity, fast response time, ..
  2. A highly multiplexed, scalable ultrananocrystalline diamond microarray sensor for
    Donato M Ceres; Fiscal Year: 2013
    ..We propose the development of electrochemical microarray sensors using boron-doped ultrananocrystalline diamond (UNCD) that promise superior sensitivity and specificity, fast response time, ..
  3. DEVELOPMENTAL CONTROL OF DNA REPLICATION IN CAULOBACTER
    LUCILLE SHAPIRO; Fiscal Year: 2013
    ..Based on our elucidation of the genetic circuitry that runs a bacterial cell cycle, we designed a new class of boron-based antibiotics that are in phase two trials...
  4. NIH SBIR Phase I: Development of a Novel Boron-doped Ultrananocrystalline Diamond
    Prabhu U Arumugam; Fiscal Year: 2011
    ..We propose here the next generation electrode material, boron-doped ultrananocrystalline diamond (BD UNCD) that offers superior sensitivity and specificity, fast response time, ..
  5. Boronated nucleosides for neutron capture therapy of brain tumors
    Werner Tjarks; Fiscal Year: 2013
    ..Therefore, the further development of novel treatment modalities for GBM, such as boron neutron capture therapy (BNCT), remains a pressing task for the health science community in the USA...
  6. Structure-function studies of the dimerization of the N-terminal domain of NBCe1-
    HARRY SINGH GILL; Fiscal Year: 2013
    ..Gill be integrated into the Physiology Lab of his mentor, Professor Walter Boron. A mentoring committee consisting of senior investigators from three institutions will guide Dr...
  7. A Multi-Purpose Nanovehicle for Targeted Boron Neutron Capture Cancer Therapy &I
    Andrew Webb; Fiscal Year: 2012
    ..As a proof-of-concept we have developed our NP to target pancreatic adenocarcinoma with boron neutron capture therapy (BNCT)...
  8. Shape Shifting Phosphines in Transition Metal Catalysis
    THOMAS JOHN MAIMONE; Fiscal Year: 2012
    ..Couplings involving electron deficient boron compounds, particularly 2-pyridyl boronic acids are an example...
  9. Functional role of transporter Slc4a11 (BTR1/NaBC1) in the cornea
    Mark Parker; Fiscal Year: 2013
    ..The available functional information suggests that SLC4A11 transports Na+ and borate [B(OH)4- ], although no boron transport experiments with this protein have been performed...
  10. Phase II Environmentally greener, efficient, and safe synthetic platform for the
    PAUL MATTHEW HERRINTON; Fiscal Year: 2011
    ..Produce oxidized products (e.g. hydroxyquinolines) where applicable. 2. Explore new boron technologies including the formation and utilization of trifluoroborate, triolate, and MIDA derivatives. 3...
  11. Novel Organoboron Chemistry Utilizing Tetrahydroxydiborane
    Gary A Molander; Fiscal Year: 2013
    ..As a result of the studies described, novel methods for the introduction of boron into organic molecules will be realized;processes that are far more sustainable than previous methods...
  12. Developing the Synthetic Utility of the Copper-Catalyzed Diboration of Aldehydes
    Timothy B Clark; Fiscal Year: 2010
    ..New methods to incorporate boron substituents into organic substrates would increase the types of molecules that could be accessed through these ..
  13. TUMOR-TARGETING WITH NEW BORONATED PORPHYRINS
    MARIA DA GRACA HENRIQUES VICENTE; Fiscal Year: 2010
    This proposal addresses the need for the development of efficient boron delivery agents for application in a new treatment modality for intractable brain tumors and other malignancies, boron neutron capture therapy (BNCT)...
  14. Chemical Synthesis of Bioactive Flavonoid and Xanthone-Derived Natural Products
    John A Porco; Fiscal Year: 2013
    ..natural products, enantioselective [4+2] cycloadditions of 2'-hydroxychalcones and dienes using chiral boron complexes, metal-catalyzed, asymmetric rearrangement of 3-alloxyflavones, vinylogous addition of siloxyfurans to 5-..
  15. Development of New Catalytic and Enantioselective Reactions
    Marc L Snapper; Fiscal Year: 2013
    ..The third objective of our program involves innovations in catalytic C-B bond formation. Carbon-boron bonds are among the most useful entities in organic chemistry, and a number of metal-catalyzed method for their ..
  16. Novel Boronic Acids for Pilot-Scale Screening
    Gary A Molander; Fiscal Year: 2010
    ..of ancillary functional groups incorporated within the organotrifluoroborates, while retaining the valuable boron carbon bonds...
  17. Discovery of Oxaboroles as New Antimalarial Agents
    Philip Jon Rosenthal; Fiscal Year: 2013
    ..This program is directed toward the development of new boron-containing small molecules as antimalarial drugs...
  18. An epithelial model for V-type H+-ATPase-driven acid-base transport
    Peter M Piermarini; Fiscal Year: 2010
    ..this transition are his mentors Professors Klaus Beyenbach and Michael Kotlikoff, and two external consultants (Boron, Yale and Harrison, Arizona State)...
  19. Novel Azaborine Derivatives Predicted to Eliminate Acetaminophen Hepatotoxicity
    DONALD ALLEN UPSON; Fiscal Year: 2011
    ..Proposed herein are new 1,2-azaborines, wherein a CC bond pair of an arene is replaced with an isosteric boron- nitrogen unit that is designed to eliminate the formation of the toxic metabolite...
  20. Plasma synthesized doped boron nanopowder for magnesium diboride superconductors
    JAMES V MARZIK; Fiscal Year: 2012
    ..The goal of this project is to develop doped boron nanopowder made by a plasma synthesis process to be used for producing MgB2...
  21. Organotrifluoroborates in Selective Organic Synthesis
    Gary A Molander; Fiscal Year: 2013
    ..as a means to build molecular complexity into the organotrifluoroborates while retaining the valuable carbon-boron bond for further transformations (i.e., using the trifluoroborate as a protected boronic acid)...
  22. Electrophilic Boranes: Directed Hydroboration, Borylation, and Related Reactions
    Edwin Vedejs; Fiscal Year: 2012
    ..The proposed studies will access synthetically important boronates using new procedures for boron activation...
  23. An Epithermal Neutron Source for Cancer Therapy
    MELVIN PIESTRUP; Fiscal Year: 2006
    ..applicant): We propose to develop a commercial neutron source for the treatment of brain and liver cancer based on boron neutron capture therapy (BNCT)...
  24. New Chiral Br??nsted Acids for Asymmetric Synthesis
    WILLIAM DEAN WULFF; Fiscal Year: 2013
    ..catalyst, its utility is greatly enhanced by the fact that it can be assembled by the substrate from the ligand, a boron source, two equivalents of an alcohol or phenol and three equivalents of water...
  25. BORON NEUTRON CAPTURE THERAPY OF OCULAR MELANOMA
    Samuel Packer; Fiscal Year: 1992
    b>Boron neutron capture therapy of malignant melanoma of the iris or choroid has the potential to 1) selectively treat melanoma with the use of boronated melanoma seeking compounds - such as p-boronophenylalanine (BPA), 2) use a form of ..
  26. Development of BN Heterocycles for Biomedical Research
    Shih Yuan Liu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Boron-containing compounds have recently emerged as useful biologically active substances with unique mechanisms of action...
  27. METAL CATALYSED ASYMMETRIC DIELS-ALDER REACTIONS
    Brice Bosnich; Fiscal Year: 1991
    ..This proposal is directed at developing chiral catalysts of the elements boron, aluminum, titanium, and tin for the catalytic asymmetric Diels-Alder reaction...
  28. Discovery of Oxaboroles as New Antimalarial Agents
    Philip Jon Rosenthal; Fiscal Year: 2011
    New drugs for malaria are greatly needed. This program is directed toward the development of new boron-containing small molecules as antimalarial drugs...
  29. ACID BASE PERMEABILITY AND TRANSPORT IN COLONIC CRYPTS
    Satish Singh; Fiscal Year: 2000
    ..Henry Binder and the regulation of intracellular pH (pHi) with Dr. Walter Boron. During his research years, the candidate has mastered fluorescence imaging techniques for monitoring pHi...
  30. SYNTHESIS AND EVALUATION OF BORONATED FOLATES FOR BNCT
    Werner Tjarks; Fiscal Year: 2001
    DESCRIPTION: (Applicant's Abstract) The development of boron compounds for the treatment of squamous cell carcinoma of the head and neck (SCCHN) by Boron Neutron Capture Therapy (BNCT) requires the synthesis and evaluation of non-toxic ..
  31. Neutron Microscope for In-Vivo Imaging
    JAY CREMER; Fiscal Year: 2005
    ..or cold neutron microscope that we will address in the proposed program is to provide a new imaging modality in boron neutron capture therapy (BNCT) for the treatment of glioblastomas and anaplastic astrocytomas...
  32. MEASUREMENT OF BORON STABLE ISOTOPES FOR CANCER THERAPY
    Morteza Janghorbani; Fiscal Year: 1993
    Development of novel boronated compounds and use of epithermal neutrons has now generated much interest in 10B-boron capture neutron therapy of different tumors...
  33. Liposome Delivery of Boron for BNCT
    M Hawthorne; Fiscal Year: 2007
    b>Boron neutron capture therapy (BNCT) is a binary radiation treatment for cancer, which requires the initial selective concentration of the boron-10 isotope within the malignant cells under attack...
  34. PROGRAM FOR DEVELOPMENT OF BNCT AGENTS
    Stephen B Kahl; Fiscal Year: 2010
    ..b>Boron neutron capture therapy (BNCT) is a form of targeted radiochemotherapy that has the potential to increase local ..
  35. IMAGING OF BORON IN TISSUE AT CELLULAR LEVEL FOR BNCT
    TOM WHITAKER; Fiscal Year: 1991
    b>Boron Neutron Capture Therapy (BNCT) is conducted by loading boron biochemically into a tumor and irradiating with thermal neutrons...
  36. CARBOCATIONS AND BIO-RELATED REACTIONS
    GEORGE OLAH; Fiscal Year: 1993
    ..New highly efficient non-oxidizing superacid systems based on boron tris- triflate and its conjugate acids will be developed for improved study of stable carbocations...
  37. A Phase II Trial for Neutron Capture Therapy in Melanoma
    Paul Busse; Fiscal Year: 2003
    ..b>Boron-delivery will be through the use of l-p-boronophenylalanine-fructose (BPA-f), 14 grams/meter-squared IV, over 90 ..
  38. BENZODIAZEPINE DERIVED CARBORANES FOR N CAPTURE THERAPY
    JOHN NEUMEYER; Fiscal Year: 1992
    DESCRIPTION (Adapted from applicant's abstract):Boron Neutron-Capture Therapy (BNCT) is a binary system for delivering intensely ionizing radiation to tumors using a combination of boron-10 labeled molecules and thermal neutrons in order ..
  39. COMPACT, INEXPENSIVE, EPITHERMAL NEUTRON SOURCE FOR BNCT
    DONALD SWENSON; Fiscal Year: 1999
    ..of this proposal is the development of a compact, inexpensive, epithermal neutron source for clinical use in boron neutron capture therapy (BNCT)...
  40. 10-BORON LABELED ANTIBODIES IN CANCER THERAPY
    M Hawthorne; Fiscal Year: 1992
    ..biology and immunology is proposed which will broaden the scope of research concerned with the application of the boron-10 neutron capture reaction, 10B(n,alpha)7Li, to cancer therapy (BNCT)...
  41. TRACE BORON QUANTITATION IN PITUITARY TISSUES FOR BNCT
    ELLISON TAYLOR; Fiscal Year: 1992
    ..killing of targeted cells when irradiated with thermal neutrons, leading to more effective cancer therapy with the Boron Neutron Capture Therapy (BNCT) technique...
  42. INTERACTION OF METHYLTRANSFERASE AND GLYCINE BORONATES
    Robert Lindquist; Fiscal Year: 1990
    ..Glycine analogs with boron in place of the methylene carbon (IV) exhibit a multiple of interesting physiological properties including ..
  43. Expanding Ligand-Metal Bifunctional Catalysis Scope
    Timothy Clark; Fiscal Year: 2007
    ..This project will allow for the introduction of boron substituents into complex organic molecules with selectivities that are not possible with the current technology...
  44. Plasma synthesized doped boron nanopowder for magnesium diboride superconductors
    JAMES MARZIK; Fiscal Year: 2007
    ..Furthermore, a high quality source of doped boron needs to be established to advance the state of the art and to ultimately commercialize MgB2 superconductors...
  45. Diamond and Hydrogenated Carbon Microelectrodes
    Greg Swain; Fiscal Year: 2004
    ..b>Boron-doped microcrystalline and nitrogen-incorporated nanocrystalline diamond films conformally deposited on 20-100 ..
  46. SELECTIVE RADIOIMMUNOTHERAPY OF COLON CANCER
    David Goldenberg; Fiscal Year: 1980
    ..This involves the design and synthesis of boron-containing compounds capable of labeling immunoglobulins prepared against carcinoembryonic antigen (CEA) with the ..
  47. BIFUNCTIONAL ANTIBODY MEDIATED NEUTRON CAPTURE THERAPY
    M Hawthorne; Fiscal Year: 1999
    ..of this project is to develop the means to utilize bi-specific immunoproteins for the selective concentration of boron-10 atoms in tumors for the boron neutron capture therapy (BNCT) of cancer...
  48. SUPERHEATED DROP DETECTORS FOR DOSIMETRY IN RADIOTHERAPY
    Ravinder Nath; Fiscal Year: 2001
    ..particle beams and for the spectrometry of neutron fields created at depth in tissue by x-ray, electron, proton or boron neutron capture therapy beams...
  49. STRUCTURAL KINETIC STUDIES BY NUCLEAR MAGNETIC RESONANCE
    Alfred Redfield; Fiscal Year: 1999
    ..Many other kinds of problems might also be studied by the method, such as bond orientations of substrates containing deuterons or 17O, or the spectroscopy of boron-containing inhibitors bound to proteins.
  50. STEREOCHEMISTRY OF A CARBON-CARBON BOND-FORMING PROCESS
    JOHN BUYNAK; Fiscal Year: 1990
    ..The reaction possesses several advantages over other dipolar or boron-mediated methods for the formation of carbon-carbon bonds: 1) It occurs under extremely mild conditions, without ..
  51. Phase I / II Trial for Neutron Capture Therapy
    Matthew Palmer; Fiscal Year: 2002
    ..The starting point will be a volume average brain dose of 7.0 RBE-Gy given in two fractions. Boron-delivery will be through the use of l-p-boronophenylalanine-fructose (BPA-f), 14 grams/meter-squared IV, over 90 ..
  52. SYNTHESIS AND MECHANISM OF SECRETION OF PAROTID PROTEINS
    MERCEDES PAZ; Fiscal Year: 1992
    ..Recent work in our laboratory succeeded in the development of several orgnic boron compounds representing a novel tool for the investigation of secretory mechanisms...
  53. ACCELERATOR PRODUCTION OF EPITHERMAL NEUTRONS FOR BNCT
    RUTH SHEFER; Fiscal Year: 1992
    The goal of the Phase II program is to construct and test an accelerator based neutron irradiation facility for boron neutron capture therapy (BNCT)...
  54. DEVELOPMENT OF AN RFQ LINAC FOR CLINICAL BNCT
    Robert Hamm; Fiscal Year: 1993
    The goal of this Phase I design study is to develop the design of an accelerator-based neutron source for clinical boron neutron capture therapy (BNCT) using the compact radio-frequency quadrupole (RFQ) linear accelerator...
  55. NEW (B22H22)2 FOR NEUTRON CAPTURE AND DIAGNOSTICS
    BERNARD SPIELVOGEL; Fiscal Year: 1999
    DESCRIPTION (Adapted from the application): Boron Neutron Capture Therapy (BNCT) for treatment of cancer has entered Phase I & II clinical trials. Polyhedral boron hydrides figure predominantly in the ongoing trials...
  56. BORONIC ACID ANALOGS OF NUCLEOSIDE-5'-PHOSPHATES
    BERNARD SPIELVOGEL; Fiscal Year: 1993
    ..Replacement of the charged phosphate group with uncharged boron containing moieties should not only enhance their cell permeability, but the new analogs are expected to be ..
  57. Accelerator-based Neutron Brachytherapy
    RUTH SHEFER; Fiscal Year: 2002
    ..neck tumors based on fast neuron brachytherapy, with or without dose augmentation by neutron by neutron capture in boron, it is proposed...
  58. Boron plasma-treatment of CoCrMo orthopedic implants
    C KLEPPER; Fiscal Year: 2004
    ..smoothness and wear properties can be produced on Co-Cr-Mo orthopedic implants when processed with an energetic boron plasma (ionized vapor) source...
  59. NUCLEOSIDE PHOSPHATE ANALOGUES WITH BORONATED PHOSPHATES
    BERNARD SPIELVOGEL; Fiscal Year: 1991
    ..The nucleoside boranophosphates may be useful in a number of ways including: l) as tools for studying mechanism of action of enzymes, 2) as antiviral and antitumor agents, and 3) as carriers of boron neutron capture therapy.
  60. BORON EPITHERMAL NEUTRON CAPTURE THERAPY
    Ralph Fairchild; Fiscal Year: 1980
    ..Physiological localization of boron in tumor permits selective irradiation of cancer cells within the radiation field, as the range of the He and Li ..
  61. NEUTRON DETECTORS FOR MACROMOLECULAR CRYSTALLOGRAPHY
    KRISHNA MANDAL; Fiscal Year: 2004
    ..the proposed program is to develop a new solid-state, large-area, and position sensitive neutron detector based on boron-doped amorphous selenium for macromolecular neutron crystallography...
  62. BORADEOXYRIBONUCLEOSIDES
    DONALD MATTESON; Fiscal Year: 1992
    Boradeoxyribonucleosides" focuses on two points where boron may replace carbon in deoxyribonucleosides to provide novel compounds which have a good chance of being antiviral agents...
  63. Catalytic Asymmetric Hydroboration: Uncapping the Potential with Two-Point Bindin
    James M Takacs; Fiscal Year: 2013
    ..The stereochemistry of carbon-boron bond is retained upon transmetallation or conversion to other useful functional groups...
  64. SYNTHESIS OF THE ANTITUMOR MACROLIDE SPONGISTATIN 1
    ANATOLY PINCHUK; Fiscal Year: 2001
    ..The project plans to achieve a convergent synthesis of spongistatin 1 based mostly on application of boron reagents for the stereocontrolled construction and coupling of smaller fragments containing the A/B, C4D, and E/F ..