Genomes and Genes
Summary: A light, silvery, metallic element. It has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. Its salts are essential in nutrition, being required for the activity of many enzymes, especially those concerned with oxidative phosphorylation. It is a component of both intra- and extracellular fluids and is excreted in the urine and feces. Deficiency causes irritability of the nervous system with tetany, vasodilation, convulsions, tremors, depression, and psychotic behavior. (From Dorland, 27th ed)
Publications344 found, 100 shown here
- Effects of magnesium and related divalent metal ions in topoisomerase structure and functionClaudia Sissi
Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
Nucleic Acids Res 37:702-11. 2009..A general two-metal ion mechanism is widely accepted to account for the biophysical and biochemical data thus far available...
- Magnesium intake and risk of type 2 diabetes: meta-analysis of prospective cohort studiesJia Yi Dong
Department of Nutrition and Food Hygiene, Soochow University, Suzhou, China
Diabetes Care 34:2116-22. 2011Emerging epidemiological evidence suggests that higher magnesium intake may reduce diabetes incidence...
- Fiber and magnesium intake and incidence of type 2 diabetes: a prospective study and meta-analysisMatthias B Schulze
Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
Arch Intern Med 167:956-65. 2007Prospective studies on fiber and magnesium intake and risk of type 2 diabetes mellitus were inconsistent...
- Structures and metal-ion-binding properties of the Ca2+-binding helix-loop-helix EF-hand motifsJessica L Gifford
Structural Biology Research Group, Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada T2N 1N4
Biochem J 405:199-221. 2007..A structural approach is used in this review to examine the diversity of family members, and a biophysical perspective provides insight into the ability of the EF-hand motif to bind Ca2+ with a wide range of affinities...
- Metal ions in biological catalysis: from enzyme databases to general principlesClaudia Andreini
Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019, Sesto Fiorentino, Italy
J Biol Inorg Chem 13:1205-18. 2008..b>Magnesium and zinc are by far the most common ions of the first type, while calcium is relatively less used...
- Ionomics: studying the social network of mineral nutrientsIvan Baxter
Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA
Curr Opin Plant Biol 12:381-6. 2009..When combined with new genotyping technologies, ionomics provides a rapid way to identify genes that control elemental accumulation in plants...
- Crystal structure of a self-spliced group II intronNavtej Toor
Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, Bass Building, New Haven, CT 06511, USA
Science 320:77-82. 2008..Structural and functional analogies support the hypothesis that group II introns and the spliceosome share a common ancestor...
- Dissecting the influence of Mg2+ on 3D architecture and ligand-binding of the guanine-sensing riboswitch aptamer domainJanina Buck
Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max von Laue Strasse 7 and 9, 60438 Frankfurt am Main, Germany
Nucleic Acids Res 38:4143-53. 2010..We propose that reduction of conformational dynamics in remote regions of the riboswitch aptamer domain is the minimal pre-requisite to pre-organize the core region for specific ligand binding...
- Idiosyncratically tuned switching behavior of riboswitch aptamer domains revealed by comparative small-angle X-ray scattering analysisNathan J Baird
Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
RNA 16:598-609. 2010..It is possible that the range of behaviors observed by SAXS, rather than being a biophysical idiosyncrasy, reflects adaptation of riboswitches to the regulatory requirements of their individual genomic context...
- Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatmentS B Sartori
Department of Pharmacology and Toxicology, Institute of Pharmacy, and Centre for Molecular Biosciences Innsbruck CMBI, University of Innsbruck, Peter Mayr Strasse 1, A 6020 Innsbruck, Austria
Neuropharmacology 62:304-12. 2012Preclinical and some clinical studies suggest a relationship between perturbation in magnesium (Mg(2+)) homeostasis and pathological anxiety, although the underlying mechanisms remain largely unknown...
- Magnesium and its alloys as orthopedic biomaterials: a reviewMark P Staiger
Department of Mechanical Engineering, University of Canterbury, Private Bag 4800, Christchurch, New Zealand
Biomaterials 27:1728-34. 2006..roles in biological systems, and in vivo degradation via corrosion in the electrolytic environment of the body, magnesium-based implants have the potential to serve as biocompatible, osteoconductive, degradable implants for load-..
- Magnesium: nutrition and metabolismJürgen Vormann
Institute for Prevention and Nutrition, Osterfeldstr 92, D 85737, Ismaning, Germany
Mol Aspects Med 24:27-37. 2003b>Magnesium is an essential mineral that is needed for a broad variety of physiological functions...
- Magnesium and diabetes mellitus: their relationCristiane Hermes Sales
Departamento de Nutricao, Universidade Federal do Rio Grande do Norte, UFRN, Centro de Ciencias da Saude, Av General Cordeiro de Farias, S N, Petropolis, Natal RN, 59010 180, Brazil
Clin Nutr 25:554-62. 2006The aim of this review was to elaborate a synthesis about the discussions on magnesium and diabetes mellitus, in the last 14 years. The magnesium deficiency has been associated with chronic diseases, amongst them, diabetes mellitus...
- Free state conformational sampling of the SAM-I riboswitch aptamer domainColby D Stoddard
Department of Chemistry and Biochemistry, University of Colorado at Boulder, UCB 215, Boulder, CO 80309 0215, USA
Structure 18:787-97. 2010..Our data reveal that the ligand binding domain adopts an ensemble of states that minimizes the energy barrier between the free and bound states to establish an efficient decision making branchpoint in the regulatory process...
- Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcriptionMarcin Nowotny
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Mol Cell 28:264-76. 2007..The region that accommodates this conformational change offers a target to develop HIV-specific inhibitors...
- Potassium, calcium, and magnesium intakes and risk of stroke in womenSusanna C Larsson
Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE 17177 Stockholm, Sweden
Am J Epidemiol 174:35-43. 2011The authors examined the association between dietary potassium, calcium, and magnesium intakes and the incidence of stroke among 34,670 women 49-83 years of age in the Swedish Mammography Cohort who completed a food frequency ..
- Dietary magnesium intake in a national sample of US adultsEarl S Ford
Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
J Nutr 133:2879-82. 2003Despite the role of magnesium in maintaining health, much of the U.S. population has historically not consumed adequate amounts of magnesium. Furthermore, significant racial or ethnic disparities in magnesium intake exist...
- Variation in intakes of calcium, phosphorus, magnesium, iron and potassium in 10 countries in the European Prospective Investigation into Cancer and Nutrition studyA A Welch
Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival, University of Cambridge, Cambridge, UK
Eur J Clin Nutr 63:S101-21. 2009..This study aimed at investigating variation in intakes of selected minerals across 10 European countries participating in the EPIC (European Prospective Investigation into Cancer and Nutrition) study...
- RNA folding and catalysis mediated by iron (II)Shreyas S Athavale
School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America
PLoS ONE 7:e38024. 2012..RNA and Fe²⁺ could, in principle, support an array of RNA structures and catalytic functions more diverse than RNA with Mg²⁺ alone...
- Hypomagnesaemia is associated with diabetes: Not pre-diabetes, obesity or the metabolic syndromeDavid Simmons
Institute of Metabolic Science, Cambridge University Hospitals NHS Foundation Trust, UK
Diabetes Res Clin Pract 87:261-6. 2010..The mechanism for the association between diabetes and hypomagnesaemia remains uncertain. This study aimed to test whether hypomagnesaemia is present in pre-diabetes, obesity and the metabolic syndrome...
- In vitro corrosion and biocompatibility of binary magnesium alloysXuenan Gu
State Key Laboratory for Turbulence and Complex System and Department of Advanced Materials and Nanotechnology, College of Engineering, Peking University, Beijing 100871, China
Biomaterials 30:484-98. 2009As bioabsorbable materials, magnesium alloys are expected to be totally degraded in the body and their biocorrosion products not deleterious to the surrounding tissues...
- Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domainsHuanghe Yang
Department of Biomedical Engineering, and Cardiac Bioelectricity and Arrhythmia Center, Washington University, 1 Brookings Drive, St Louis, Missouri 63130, USA
Nat Struct Mol Biol 15:1152-9. 2008..These results suggest that the VSD and the cytoplasmic domains from different subunits may interact during channel gating, and the packing of VSD or the RCK1 domain to the pore in BK channels differ from that in Kv1.2 or MthK channels...
- Level of trace elements (copper, zinc, magnesium and selenium) and toxic elements (lead and mercury) in the hair and nail of children with autismMalarveni Damodaran Lakshmi Priya
Department of Biochemistry, Bharathi Women s College, Chennai, 600 108 Tamil Nadu, India
Biol Trace Elem Res 142:148-58. 2011..the purpose of the present study was to assess the levels of trace elements like copper (Cu), zinc (Zn), magnesium (Mg), and selenium (Se) and toxic elements like mercury (Hg), and lead (Pb) in the hair and nail samples of ..
- Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)J O Lee
Laboratory of X ray Crystallography, Dana Farber Cancer Institute, Harvard Medical School Boston, Massachusetts 02115
Cell 80:631-8. 1995..Our crystal structure will allow reliable models to be built for other members of the A domain superfamily and should facilitate development of novel adhesion modulatory drugs...
- Hypomagnesemia in patients with type 2 diabetesPhuong Chi T Pham
Olive View UCLA Medical Center, 14445 Olive View Drive, Department of Medicine, 2B 182, Nephrology Division, Sylmar, CA 91342, USA
Clin J Am Soc Nephrol 2:366-73. 2007..This article reviews the literature on the metabolism of magnesium, incidence of hypomagnesemia in patients with type 2 diabetes, implicated contributing factors, and associated ..
- TRPM6 and TRPM7: A Mul-TRP-PLIK-cation of channel functionsLoren W Runnels
Department of Pharmacology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
Curr Pharm Biotechnol 12:42-53. 2011..Soon after their identification, the two proteins were quickly linked to the regulation of magnesium homeostasis...
- Vascular smooth muscle cell differentiation to an osteogenic phenotype involves TRPM7 modulation by magnesiumAugusto C Montezano
OHRI University of Ottawa, 451 Smyth Road, Ottawa, K1H 8M5 Ontario, Canada
Hypertension 56:453-62. 2010..Clinical studies suggest that magnesium may prevent this, but mechanisms are unclear...
- Second messenger role for Mg2+ revealed by human T-cell immunodeficiencyFeng Yen Li
Molecular Development Section, Lymphocyte Molecular Genetics Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 475:471-6. 2011The magnesium ion, Mg(2+), is essential for all life as a cofactor for ATP, polyphosphates such as DNA and RNA, and metabolic enzymes, but whether it plays a part in intracellular signalling (as Ca(2+) does) is unknown...
- Evaluation of short-term effects of rare earth and other elements used in magnesium alloys on primary cells and cell linesFrank Feyerabend
Department of Structural Research on Macromolecules, GKSS Research Centre, Institute for Materials Research, Max Planck Strasse 1, D 21502 Geesthacht, Germany
Acta Biomater 6:1834-42. 2010Degradable magnesium alloys for biomedical application are on the verge of being used clinically. Rare earth elements (REEs) are used to improve the mechanical properties of the alloys, but in more or less undefined mixtures...
- Magnesium, inflammation, and obesity in chronic diseaseForrest H Nielsen
US Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, North Dakota 58202 9034, USA
Nutr Rev 68:333-40. 2010About 60% of adults in the United States do not consume the estimated average requirement for magnesium, but widespread pathological conditions attributed to magnesium deficiency have not been reported...
- The ligand-free state of the TPP riboswitch: a partially folded RNA structureMona Ali
Department of Applied Physics, Stanford University, Stanford, CA 94305, USA
J Mol Biol 396:153-65. 2010..Our results also demonstrate the power of combining experimental small-angle X-ray scattering data with theoretical structure prediction tools in the determination of RNA structures beyond riboswitches...
- Transient receptor potential melastatin 7 ion channels regulate magnesium homeostasis in vascular smooth muscle cells: role of angiotensin IIYing He
CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Canada
Circ Res 96:207-15. 2005b>Magnesium modulates vascular smooth muscle cell (VSMC) function. However, molecular mechanisms regulating VSMC Mg2+ remain unknown...
- Dietary calcium and magnesium intakes and the risk of type 2 diabetes: the Shanghai Women's Health StudyRaquel Villegas
Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
Am J Clin Nutr 89:1059-67. 2009..Diet plays a key role in the development of type 2 diabetes (T2D), but little is known about the contributions of specific nutrients in populations in which dietary patterns differ from Western populations...
- Parathyroid hormone, but not vitamin D, is associated with the metabolic syndrome in morbidly obese women and men: a cross-sectional studyJøran Hjelmesaeth
Morbid Obesity Center, Vestfold Hospital Trust, Health Region South, Tønsberg, Norway
Cardiovasc Diabetol 8:7. 2009..Further, low serum levels of 25-hydroxyvitamin D (25 [OH]D) and magnesium have been associated with increased risk of the metabolic syndrome (MS), and recently, a possible link between ..
- Mg2+ and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytesDavid C Wrighton
Centre for Neuroscience Research, Hugh Robson Building, University of Edinburgh, George Square, Edinburgh, UK
J Physiol 586:211-25. 2008..We suggest that the potency of block of NMDARs by Mg(2+) is influenced not only by pore-forming regions but also the LBD and the resulting conformational changes that occur following agonist binding...
- Glycemic index and dietary fiber and the risk of type 2 diabetesAllison M Hodge
Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia
Diabetes Care 27:2701-6. 2004..To examine associations between type 2 diabetes and fiber, glycemic load (GL), dietary glycemic index (GI), and fiber-rich foods...
- Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product releaseMarcin Nowotny
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
EMBO J 25:1924-33. 2006..Lastly, product release probably requires dissociation of metal ion A, which is inhibited by either high concentrations of divalent cations or mutation of an assisting protein residue...
- Structures of the bacterial ribosome at 3.5 A resolutionBarbara S Schuwirth
Department of Chemistry, University of California, Berkeley, CA 94720, USA
Science 310:827-34. 2005....
- Evaluation of the skin sensitizing potential of biodegradable magnesium alloysFrank Witte
Department of Orthopaedic Surgery, Hannover Medical School, Hannover, Germany
J Biomed Mater Res A 86:1041-7. 2008Corroding metals made of magnesium alloys represent a new class of degradable implants for musculoskeletal surgery. These implants may be associated with skin sensitizing reactions because of the release of metal ions...
- Cadmium toxicity revisited: focus on oxidative stress induction and interactions with zinc and magnesiumVesna Matovic
Department of Toxicology Akademik Danilo Soldatović, Faculty of Pharmacy, University of Belgrade, Serbia
Arh Hig Rada Toksikol 62:65-76. 2011..gives a brief review of cadmium-induced oxidative stress and its interactions with essential elements zinc and magnesium as relevant mechanisms of cadmium toxicity...
- Serum magnesium and risk of sudden cardiac death in the Atherosclerosis Risk in Communities (ARIC) StudyJames M Peacock
University of Minnesota, Minneapolis, 55454, USA
Am Heart J 160:464-70. 2010We hypothesized that serum magnesium (Mg) is associated with increased risk of sudden cardiac death (SCD).
- Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistanceMario Barbagallo
Institute of Internal Medicine and Geriatrics, University of Palermo, Italy
Arch Biochem Biophys 458:40-7. 2007....
- Magnesium sulfate for neuroprotection after traumatic brain injury: a randomised controlled trialNancy R Temkin
Department of Neurological Surgery, University of Washington, Seattle, USA
Lancet Neurol 6:29-38. 2007Traumatic brain injuries represent an important and costly health problem. Supplemental magnesium positively affects many of the processes involved in secondary injury after traumatic brain injury and consistently improves outcome in ..
- Magnesium fluctuations modulate RNA dynamics in the SAM-I riboswitchRyan L Hayes
Center for Theoretical Biological Physics and Department of Physics and Astronomy, Rice University, Houston, Texas 77005 1892, USA
J Am Chem Soc 134:12043-53. 2012..Rather than a few inner-sphere ions anchoring the RNA structure surrounded by a continuum of diffuse ions, we observe a layer of outer-sphere coordinated Mg(2+) that is transiently bound but strongly coupled to the RNA...
- Prevention of malathion-induced depletion of cardiac cells mitochondrial energy and free radical damage by a magnetic magnesium-carrying nanoparticleHoda Shafiee
Pharmaceutical Sciences Branch, Islamic Azad University
Toxicol Mech Methods 20:538-43. 2010....
- Dietary magnesium intake is related to metabolic syndrome in older AmericansNicola M McKeown
Nutritional Epidemiology Department, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Eur J Nutr 47:210-6. 2008b>Magnesium (Mg) is an essential cofactor for enzymes involved in glucose and insulin metabolism. Low intakes of dietary magnesium may be linked to greater risk of metabolic syndrome (MS) in older adults.
- Magnesium reduces calcification in bovine vascular smooth muscle cells in a dose-dependent mannerFatih Kircelli
Division of Nephrology, Ege University School of Medicine, Izmir, Turkey
Nephrol Dial Transplant 27:514-21. 2012..In clinical studies, an inverse relationship between serum magnesium and VC has been reported...
- Lack of association between serum magnesium and the risks of hypertension and cardiovascular diseaseAbigail May Khan
Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Am Heart J 160:715-20. 2010..Prior clinical studies have yielded conflicting results but were limited by the use of self-reported magnesium intake or short follow-up periods.
- Low serum magnesium and cardiovascular mortality in chronic heart failure: a propensity-matched studyChris Adamopoulos
Papageorgiou General Hospital, Thessaloniki, Greece
Int J Cardiol 136:270-7. 2009Low serum magnesium levels may cause fatal ventricular arrhythmias. However, their long-term effects on mortality and morbidity in chronic heart failure patients are relatively unknown.
- Skeletal and hormonal effects of magnesium deficiencyRobert K Rude
USC Keck School of Medicine, Los Angeles, CA, USA
J Am Coll Nutr 28:131-41. 2009b>Magnesium (Mg) is the second most abundant intracellular cation where it plays an important role in enzyme function and trans-membrane ion transport...
- Intake of potassium, magnesium, calcium, and fiber and risk of stroke among US menA Ascherio
Department of Nutrition, Epidemiology and Health and Social Behavior, Harvard School of Public Health, Boston, MA 02115, USA
Circulation 98:1198-204. 1998..Animal experiments and epidemiological studies have suggested that high potassium intake may reduce the risk of stroke, but the evidence is inconclusive, and the role of other nutrients in potassium-rich foods remains unknown...
- Impaired mitochondrial bioenergetics determines glutamate-induced delayed calcium deregulation in neuronsAndrey Y Abramov
Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3 BG, UK
Biochim Biophys Acta 1800:297-304. 2010..Exposure of neurons to toxic glutamate concentrations causes an initial transient increase in [Ca(2+)](c) followed by a delayed increase commonly termed delayed [Ca(2+)](c) deregulation (DCD)...
- Initial clinical experience of vasodilatory effect of intra-cisternal infusion of magnesium sulfate for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhageKentaro Mori
Department of Neurosurgery, Juntendo University Shizuoka Hospital, 1129 Nagaoka, Izunokuni, Shizuoka, Japan
Neurol Med Chir (Tokyo) 49:139-44; discussion 144-5. 2009The vasodilatory effect of intra-cisternal infusion of magnesium sulfate solution was evaluated in 10 patients with symptomatic vasospasm after aneurysmal subarachnoid hemorrhage (SAH) who underwent early clipping surgery...
- Initial evidence for the return of coronary vasoreactivity following the absorption of bioabsorbable magnesium alloy coronary stentsGopal Ghimire
Royal Brompton and Harefield NHS Trust, Imperial College, London, United Kingdom
EuroIntervention 4:481-4. 2009..the endothelium independent coronary smooth muscle vasomotor function four months after implantation of magnesium alloy absorbable metal stents (AMS) as part of the Progress-AMS clinical trial (n = 5), compared with a control ..
- Role of magnesium in genomic stabilityA Hartwig
Department of Food Chemistry and Toxicology, University of Karlsruhe, Profach 6980, D 76128, Karlsruhe, Germany
Mutat Res 475:113-21. 2001In cellular systems, magnesium is the second most abundant element and is involved in basically all metabolic pathways...
- A recurrent magnesium-binding motif provides a framework for the ribosomal peptidyl transferase centerChiaolong Hsiao
School of Chemistry and Biochemistry, Parker H Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332 0400, USA
Nucleic Acids Res 37:3134-42. 2009..Here we demonstrate that the ribosomal peptidyl transferase center (PTC) is supported by a framework of magnesium microclusters (Mg(2+)-muc's)...
- Single-molecule analysis of protein-free U2-U6 snRNAsZhuojun Guo
Department of Chemistry, Wayne State University, Detroit, Michigan, USA
Nat Struct Mol Biol 16:1154-9. 2009..The first step is strongly magnesium dependent, and we provide evidence suggesting that the second step corresponds to the formation of the ..
- Role of magnesium in alleviation of aluminium toxicity in plantsJayakumar Bose
School of Earth and Environment, Faculty of Natural and Agricultural Sciences, University of Western Australia, Crawley WA 6009, Australia
J Exp Bot 62:2251-64. 2011b>Magnesium is pivotal for activating a large number of enzymes; hence, magnesium plays an important role in numerous physiological and biochemical processes affecting plant growth and development...
- Relationship between magnesium and clinical biomarkers on inhibition of vascular calcificationSilvia Salem
Charite, Medical Clinic IV, University of Berlin, Germany
Am J Nephrol 35:31-9. 2012..This study focuses on the most likely protective effects of magnesium ion (Mg(2+)) on phosphate-induced vascular calcification ex vivo/in vitro...
- A structural equation model for assessment of links between changes in serum triglycerides, -urate, and -glucose and changes in serum calcium, -magnesium and -phosphate in type 2 diabetes and non-diabetes metabolismLena Håglin
Department of Public Health and Clinical Medicine, Family Medicine, Umea University, SE 901 87 Umea, Sweden
Cardiovasc Diabetol 10:116. 2011..between changes in serum triglycerides (S-TG), -urate (S-Urate), and -glucose (S-Glu) and changes in serum calcium (S-Ca), -magnesium (S-Mg), and -phosphate (S-P) in patients with type 2 diabetes compared with non-diabetic patients.
- Permeant ion effects on external Mg2+ block of NR1/2D NMDA receptorsAnqi Qian
Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurosci 26:10899-910. 2006..Differences in the Mg2+(o) blocking site, and particularly in the selectivity filter and internal channel entrance, are principally responsible for the subunit dependence of Mg2+(o) block...
- Structural transitions and thermodynamics of a glycine-dependent riboswitch from Vibrio choleraeJan Lipfert
Department of Physics, Stanford University, Stanford, CA 94305, USA
J Mol Biol 365:1393-406. 2007..We fit a simple three-state thermodynamic model that describes the energetic coupling between magnesium-induced folding and glycine binding...
- Structural insights into ligand recognition by a sensing domain of the cooperative glycine riboswitchLili Huang
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Mol Cell 40:774-86. 2010....
- The Saccharomyces cerevisiae PHM8 gene encodes a soluble magnesium-dependent lysophosphatidic acid phosphataseVenky Sreedhar Reddy
Lipid Laboratory, Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India
J Biol Chem 283:8846-54. 2008..In vitro assays of the purified recombinant Phm8p revealed magnesium-dependent LPA phosphatase activity, with maximal activity at pH 6.5...
- Effects of magnesium supplementation in hypertensive patients: assessment by office, home, and ambulatory blood pressuresY Kawano
Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
Hypertension 32:260-5. 1998An increase in magnesium intake has been suggested to lower blood pressure (BP). However, the results of clinical studies are inconsistent...
- Nonsense-mediated mRNA decay maintains translational fidelity by limiting magnesium uptakeMarcus J O Johansson
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Genes Dev 24:1491-5. 2010..that the reduced termination efficiency of NMD-deficient cells is attributable to increased expression of the magnesium transporter Alr1p and the resulting effects of elevated Mg(2+) levels on termination fidelity...
- Discovering structural motifs using a structural alphabet: application to magnesium-binding sitesMinko Dudev
Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
BMC Bioinformatics 8:106. 2007..Our motif discovery method employs structural alphabet encoding to convert 3D structures to the corresponding 1D structural letter sequences, where the Mg2+-structural motifs are identified as recurring structural patterns...
- The unique nature of mg2+ channelsAndrea S Moomaw
Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
Physiology (Bethesda) 23:275-85. 2008..Many questions about these channels remain, however, including the molecular basis of Mg2+ selectivity and the physiological role(s) of their eukaryotic homologs...
- Cell (patho)physiology of magnesiumFederica I Wolf
Istituto di Patologia generale e Centro di Ricerche Oncologiche Giovanni XXIII, Facolta di Medicina, Universita Cattolica del Sacro Cuore, Largo F Vito 1, 00168 Roma, Italy
Clin Sci (Lond) 114:27-35. 2008There is an unsettled debate about the role of magnesium as a 'chronic regulator' of biological functions, as opposed to the well-known role for calcium as an 'acute regulator'...
- Mrs2p forms a high conductance Mg2+ selective channel in mitochondriaRainer Schindl
Institute for Biophysics, University of Linz, Linz, Austria
Biophys J 93:3872-83. 2007..We conclude that Mrs2p forms a high conductance Mg(2+) selective channel that controls Mg(2+) influx into mitochondria by an intrinsic negative feedback mechanism...
- Intrathecal magnesium prolongs fentanyl analgesia: a prospective, randomized, controlled trialAsokumar Buvanendran
Department of Anesthesiology, Rush Medical College at Rush Presbyterian St Luke s Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA
Anesth Analg 95:661-6, table of contents. 2002b>Magnesium is a noncompetitive, N-methyl-D-aspartate receptor antagonist that does not effectively cross the blood-brain barrier when given IV...
- Cisplatin nephrotoxicity affects magnesium and calcium metabolismMarshall P Goren
Department of Urology, The University of Tennessee, Memphis, Tennessee, USA
Med Pediatr Oncol 41:186-9. 2003Cisplatin is not directly toxic to bone, but cisplatin nephrotoxicity leading to magnesium wasting may affect magnesium and calcium metabolism, both of which contribute to bone integrity...
- Catalytic mechanism of NADP(+)-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexesJ H Hurley
Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0448
Biochemistry 30:8671-8. 1991The structures of NADP+ and magnesium isocitrate bound to the NADP(+)-dependent isocitrate dehydrogenase of Escherichia coli have been determined and refined at 2.5-A resolution...
- Dietary fiber, magnesium, and glycemic load alter risk of type 2 diabetes in a multiethnic cohort in HawaiiBeth N Hopping
Department of Epidemiology, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
J Nutr 140:68-74. 2010The influence of dietary fiber, magnesium (Mg), and glycemic load (GL) on diabetes was examined in the Hawaii component of the Multiethnic Cohort...
- Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neuronsYasnory F Sasaki
Center for Neuroscience and Aging, The Burnham Institute, La Jolla, California 92037, USA
J Neurophysiol 87:2052-63. 2002..Finally, a new longer splice variant of NR3A has been cloned and found to be expressed in rodent cortical neurons by single-cell RT-PCR and in situ hybridization...
- Magnesium and the inflammatory response: potential physiopathological implicationsAndrzej Mazur
Equipe Stress Métabolique et Micronutriments, Unité de Nutrition Humaine UMR 1019, Centre de Recherche en Nutrition Humaine d Auvergne, INRA, Theix, St Genes Champanelle, France
Arch Biochem Biophys 458:48-56. 2007The purpose of this review is to summarize experimental findings showing that magnesium modulates cellular events involved in inflammation...
- A tetracycline-binding RNA aptamerC Berens
Institute of Microbiology and Genetics, Vienna Biocenter Dr. Bohrgasse 9/4, A-1030, Vienna, Austria
Bioorg Med Chem 9:2549-56. 2001..Binding of tetracycline to cb28 is magnesium dependent. The secondary structure of cb28 was determined by lead cleavage and DMS modification...
- Low serum magnesium levels and foot ulcers in subjects with type 2 diabetesM Rodriguez-Moran
Unidad de Investigacion Medica en Epidemiologia Clinica, Hospital General, Instituto Mexicano del Seguro Social IMSS, Durango, Mexico
Arch Med Res 32:300-3. 2001..Thus, the aim of this study was to determine the relationship between low serum magnesium and foot ulcer in subjects with type 2 diabetes.
- A second magnesium ion is critical for ATP binding in the kinase domain of the oncoprotein v-FpsP Saylor
Department of Chemistry, San Diego State University, California 92182 1030, USA
Biochemistry 37:12624-30. 1998The activity of the kinase domain of the oncoprotein v-Fps was found to be sensitive to the concentration of magnesium ions...
- Hypomagnesemia and hypermagnesemiaJoel Michels Topf
University of Chicago, Chicago, IL 60615, USA
Rev Endocr Metab Disord 4:195-206. 2003
- Substrate discrimination in RNase P RNA-mediated cleavage: importance of the structural environment of the RNase P cleavage siteEma Kikovska
Department of Cell and Molecular Biology Box 596, Biomedical Centre, SE 751 24 Uppsala, Sweden
Nucleic Acids Res 33:2012-21. 2005..Finally, we provide evidence that the structural architecture influences Mg2+ binding, most likely in its vicinity...
- Potentials of magnesium treatment in subarachnoid haemorrhageW M van den Bergh
Department of Neurology, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands
Magnes Res 17:301-13. 2004..The interval between the bleeding and the onset of ischemia provides an opportunity for preventive treatment. Magnesium is readily available, inexpensive and has a well-established clinical profile in obstetrical and cardiovascular ..
- PhoP-PhoQ activates transcription of pmrAB, encoding a two-component regulatory system involved in Salmonella typhimurium antimicrobial peptide resistanceJ S Gunn
University of Washington, Seattle 98195, USA
J Bacteriol 178:6857-64. 1996..These data suggest that resistance to the polymyxin-CAP family is controlled by a cascade of regulatory protein expression that activates transcription upon environmental sensing...
- Magnesium deficiency and osteoporosis: animal and human observationsRobert K Rude
University of Southern California and the Orthopaedic Hospital, Los Angeles, CA 90089 9317, USA
J Nutr Biochem 15:710-6. 2004..elderly, there continues to be a need for well-designed clinical and animal studies on the link between dietary magnesium (Mg) intake and osteoporosis...
- Pseudomonas aeruginosa produces an extracellular deoxyribonuclease that is required for utilization of DNA as a nutrient sourceHeidi Mulcahy
Department of Microbiology and Infectious Diseases, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada
Environ Microbiol 12:1621-9. 2010..aeruginosa that enables degradation of extracellular DNA into an accessible source of carbon, nitrogen and phosphate. DNase production by P. aeruginosa also has important implications for virulence and biofilm formation...
- Free intracellular Mg(2+) concentration and inhibition of NMDA responses in cultured rat neuronsY Li-Smerin
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Physiol 533:729-43. 2001..This differential effect of Mg(2+)(i) on channel gating explains why Mg(2+)(i) inhibits whole-cell NMDA responses less effectively than patch responses...
- Effect of Mg2+ on the DNA binding modes of the Streptococcus pneumoniae SsbA and SsbB proteinsDiane E Grove
Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
J Biol Chem 281:2087-94. 2006..Additional experiments with a chimeric SsbA/B protein indicated that the structural determinants that govern the transitions between the different DNA binding modes may be contained within the N-terminal domains of the SSB proteins...
- Dictyostelium myosin-IE is a fast molecular motor involved in phagocytosisUlrike Dürrwang
Abteilung Biophysik, Max Planck Institut fur medizinische Forschung, Jahnstr 29, 69120 Heidelberg, Germany
J Cell Sci 119:550-8. 2006..Changes in the level of free Mg(2+) ions, which are within the physiological range, are shown to modulate the motor activity of myosin-IE by inhibiting the release of adenosine diphosphate...
- Magnesium intake and risk of type 2 diabetes: a meta-analysisS C Larsson
Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
J Intern Med 262:208-14. 2007To assess the association between magnesium intake and risk of type 2 diabetes.
- Metal-ion binding and metal-ion induced folding of the adenine-sensing riboswitch aptamer domainJonas Noeske
Department of Biochemistry, The University of Texas Health Science Center San Antonio, San Antonio, TX 78229, USA
Nucleic Acids Res 35:5262-73. 2007..Compared to the highly similar guanine-sensing riboswitch, the folding pathway for the adenine-sensing riboswitch aptamer domain is more complex and the influence of Mg2+ is more pronounced...
- Principles of RNA compaction: insights from the equilibrium folding pathway of the P4-P6 RNA domain in monovalent cationsKeiji Takamoto
Department of Physiology and Biophysics, Albert Einstein College of Medicine of Yeshiva University, New York, NY 10461, USA
J Mol Biol 343:1195-206. 2004..The folding model derived from these and previous results provides a robust framework for understanding the equilibrium and kinetic folding of RNA...
- Crystal structure of the lysine riboswitch regulatory mRNA elementAndrew D Garst
Department of Chemistry and Biochemistry, University of Colorado, Boulder, Boulder, Colorado 80309, USA
J Biol Chem 283:22347-51. 2008....
- Contribution of the PhoP-PhoQ and PmrA-PmrB two-component regulatory systems to Mg2+-induced gene regulation in Pseudomonas aeruginosaJoseph B McPhee
Department of Microbiology and Immunology and Centre for Microbial Diseases and Immunity Research, University of British Columbia, 232 2259 Lower Mall, Vancouver, BC, Canada V6T 1Z4
J Bacteriol 188:3995-4006. 2006..The number of known PmrA-regulated genes was expanded to include the PA1559-PA1560, PA4782-PA4781, and feoAB operons, in addition to the previously known PA4773-PA4775-pmrAB and pmrHFIJKLM-ugd operons...
- Glycogen synthase kinase-3 inhibition by lithium and beryllium suggests the presence of two magnesium binding sitesW Jonathan Ryves
MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
Biochem Biophys Res Commun 290:967-72. 2002Lithium inhibits (Li(+)) glycogen synthase kinase-3 (GSK-3) by competition for magnesium (Mg(2+)), but not ATP or substrate...
- RNA folding: thermodynamic and molecular descriptions of the roles of ionsDavid E Draper
Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218, USA
Biophys J 95:5489-95. 2008....
- The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporterG Zsurka
Vienna Biocenter, Department of Microbiology and Genetics, University of Vienna, Dr Bohrgasse 9, Vienna, A 1030, Austria
Genomics 72:158-68. 2001..on the human MRS2 gene that encodes a protein, hsaMrs2p, the first molecularly characterized candidate for a magnesium transporter in metazoa...
- The yeast plasma membrane protein Alr1 controls Mg2+ homeostasis and is subject to Mg2+-dependent control of its synthesis and degradationA Graschopf
Vienna Biocenter, Institute of Microbiology and Genetics, University of Vienna, A-1030 Vienna, Austria
J Biol Chem 276:16216-22. 2001..The results are discussed in terms of Alr1p being a plasma membrane transporter with high selectivity for Mg(2+)...
- Mrs2p is an essential component of the major electrophoretic Mg2+ influx system in mitochondriaMartin Kolisek
Vienna Biocenter, Institute of Microbiology and Genetics, University of Vienna, Dr Bohrgasse, A 1030 Vienna, Austria
EMBO J 22:1235-44. 2003..Taken together, these findings characterize Mrs2p as the first molecularly identified metal ion channel protein in the inner mitochondrial membrane...
- The inward rectification mechanism of the HERG cardiac potassium channelP L Smith
Department of Neurobiology, Harvard Medical School, Boston, MA 02114 2698, USA
Nature 379:833-6. 1996..The characteristics of this gating suggest a specific role for this channel in the normal suppression of arrhythmias...
- The SAL1 gene of Arabidopsis, encoding an enzyme with 3'(2'),5'-bisphosphate nucleotidase and inositol polyphosphate 1-phosphatase activities, increases salt tolerance in yeastF J Quintero
Departamento de Biotecnologia, Universidad Politecnica de Madrid, Spain
Plant Cell 8:529-37. 1996..We propose that the product of SAL1 participates in the sulfur assimilation pathway as well as in the phosphoinositide signaling pathway and that changes in the latter may affect Na+ and Li+ fluxes...
- Drosophila TRPM channel is essential for the control of extracellular magnesium levelsThomas Hofmann
Institut fur Pharmakologie und Toxikologie, Philipps Universitat Marburg, Marburg, Germany
PLoS ONE 5:e10519. 2010..These data provide the first evidence for a role for a Drosophila TRP channel in Mg2+ homeostasis, and underscore a broad and evolutionarily conserved role for TRPM channels in Mg2+ homeostasis...
- MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMAH Winn; Fiscal Year: 2001..Using a randomized, double-blind design, the present study will evaluate magnesium sulfate as a neuroprotectant and anti-epileptogenic agent following head injury...
- MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMANancy Temkin; Fiscal Year: 2004..of moderate or severe head injury the ongoing trial tests whether these consequence can be ameliorated by magnesium sulfate...
- Sodium and Cardiovascular Disease in Patients with Chronic Kidney DiseaseJiang He; Fiscal Year: 2009..between dietary intake of sodium, potassium (estimated from multiple 24-hour urinary excretion), calcium, and magnesium (estimated from multiple food frequency questionnaires [FFQ]) and the risk of clinical CVD (including coronary ..
- Prevention of neointimal thickening by Mst1Junichi Sadoshima; Fiscal Year: 2006..delivery of Mst1 from stents, we will utilize completely biodegradable stents made of noncombustible magnesium and a proprietary technique to coat the stents with mammalian expression plasmids, which can be efficiently ..
- Characterizing RNA-metal binding by Raman spectroscopyPaul Carey; Fiscal Year: 2009..b>Magnesium binding sites in the crystal structures that have been characterized by X-ray crystallography are being used to ..
- Characterizing RNA-metal binding by Raman spectroscopyPaul R Carey; Fiscal Year: 2010..b>Magnesium binding sites in the crystal structures that have been characterized by X-ray crystallography are being used to ..
- Sodium and Cardiovascular Disease in Patients with Chronic Kidney DiseaseJiang He; Fiscal Year: 2010..between dietary intake of sodium, potassium (estimated from multiple 24-hour urinary excretion), calcium, and magnesium (estimated from multiple food frequency questionnaires [FFQ]) and the risk of clinical CVD (including coronary ..
- RISK FACTORS FOR AGED RELATED BONE LOSSDouglas Kiel; Fiscal Year: 2000..and the effect on bone loss of specific nutrients that have not been well-studied with regard to bone, including magnesium, potassium, vitamin C, sodium, and vitamin K...
- Structural Basis for Bridged Bimetallic Enzyme CatalysisDagmar Ringe; Fiscal Year: 2009..A large percentage of those contain two metal ions (usually first-row transition metals or magnesium) connected by a bridging ligand (usually a carboxylate group)...
- Structural Basis for Bridged Bimetallic Enzyme CatalysisDagmar Ringe; Fiscal Year: 2007..A large percentage of those contain two metal ions (usually first-row transition metals or magnesium) connected by a bridging ligand (usually a carboxylate group)...
- COMPREHENSIVE SICKLE CELL CENTERWinfred Wang; Fiscal Year: 2006..chemotherapy" for reducing the frequency of pain crises through a Phase III trial of hydroxyurea and magnesium vs. hydroxyurea and placebo in pediatric and adult patients...
- Dietary Calcium and Magnesium, Genetics, and Colorectal AdenomaQi Dai; Fiscal Year: 2009..in the Tennessee Colorectal Polyp Study (TCPS; P50CA95103) that the associations between intake of calcium or magnesium and risk of colorectal adenoma and hyperplastic polyps may differ by the common Thr1482Ile polymorphism of the ..
- Dietary Calcium and Magnesium, Genetics, and Colorectal AdenomaQi Dai; Fiscal Year: 2010..in the Tennessee Colorectal Polyp Study (TCPS;P50CA95103) that the associations between intake of calcium or magnesium and risk of colorectal adenoma and hyperplastic polyps may differ by the common Thr1482Ile polymorphism of the ..
- Structural basis of tetracycline resistance by efflux pump TetLDa Neng Wang; Fiscal Year: 2010..is mediated by membrane transporter proteins that catalyze efflux of tetracyclines in the form of tetracycline-magnesium complex. The structural basis for substrate recognition by such efflux proteins is poorly understood...
- Psychophysics of Divalent Salts and Metallic TasteHARRY LAWLESS; Fiscal Year: 2006..of the period table including calcium, an active participant in various steps of taste transduction, as well as magnesium and barium...
- Magnesium's Antihypertensive Effects in PreeclampsiaCYNTHIA STANDLEY; Fiscal Year: 2003..b>Magnesium sulfate is the standard treatment for preeclampsia...
- Aldosteron, Intracellular Leukocyte Magnesium and Inflammation in DiabetesJose R Romero; Fiscal Year: 2010..stimulates Na+/Mg2+ exchange activity in isolated human leukocytes leading to a decrease in intracellular magnesium and an increase in expression of pro-inflammatory factors...
- Aldosteron, Intracellular Leukocyte Magnesium and Inflammation in DiabetesJose Romero; Fiscal Year: 2009..stimulates Na+/Mg2+ exchange activity in isolated human leukocytes leading to a decrease in intracellular magnesium and an increase in expression of pro-inflammatory factors...
- INDOMETHACIN FOR ADJUVANT TOCOLYSISGeorge Macones; Fiscal Year: 2004..b>Magnesium sulfate is currently the most commonly prescribed agent for tocolysis in the United States...