magnesium

Summary

Summary: A light, silvery, metallic element. It has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. Its salts are essential in nutrition, being required for the activity of many enzymes, especially those concerned with oxidative phosphorylation. It is a component of both intra- and extracellular fluids and is excreted in the urine and feces. Deficiency causes irritability of the nervous system with tetany, vasodilation, convulsions, tremors, depression, and psychotic behavior. (From Dorland, 27th ed)

Top Publications

  1. pmc Effects of magnesium and related divalent metal ions in topoisomerase structure and function
    Claudia Sissi
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
    Nucleic Acids Res 37:702-11. 2009
  2. pmc Magnesium intake and risk of type 2 diabetes: meta-analysis of prospective cohort studies
    Jia Yi Dong
    Department of Nutrition and Food Hygiene, Soochow University, Suzhou, China
    Diabetes Care 34:2116-22. 2011
  3. ncbi Fiber and magnesium intake and incidence of type 2 diabetes: a prospective study and meta-analysis
    Matthias B Schulze
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Arch Intern Med 167:956-65. 2007
  4. ncbi Structures and metal-ion-binding properties of the Ca2+-binding helix-loop-helix EF-hand motifs
    Jessica L Gifford
    Structural Biology Research Group, Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    Biochem J 405:199-221. 2007
  5. doi Metal ions in biological catalysis: from enzyme databases to general principles
    Claudia Andreini
    Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019, Sesto Fiorentino, Italy
    J Biol Inorg Chem 13:1205-18. 2008
  6. pmc Ionomics: studying the social network of mineral nutrients
    Ivan Baxter
    Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA
    Curr Opin Plant Biol 12:381-6. 2009
  7. doi Crystal structure of a self-spliced group II intron
    Navtej Toor
    Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, Bass Building, New Haven, CT 06511, USA
    Science 320:77-82. 2008
  8. pmc Dissecting the influence of Mg2+ on 3D architecture and ligand-binding of the guanine-sensing riboswitch aptamer domain
    Janina Buck
    Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max von Laue Strasse 7 and 9, 60438 Frankfurt am Main, Germany
    Nucleic Acids Res 38:4143-53. 2010
  9. pmc Idiosyncratically tuned switching behavior of riboswitch aptamer domains revealed by comparative small-angle X-ray scattering analysis
    Nathan J Baird
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    RNA 16:598-609. 2010
  10. pmc Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment
    S B Sartori
    Department of Pharmacology and Toxicology, Institute of Pharmacy, and Centre for Molecular Biosciences Innsbruck CMBI, University of Innsbruck, Peter Mayr Strasse 1, A 6020 Innsbruck, Austria
    Neuropharmacology 62:304-12. 2012

Detail Information

Publications344 found, 100 shown here

  1. pmc Effects of magnesium and related divalent metal ions in topoisomerase structure and function
    Claudia Sissi
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
    Nucleic Acids Res 37:702-11. 2009
    ..A general two-metal ion mechanism is widely accepted to account for the biophysical and biochemical data thus far available...
  2. pmc Magnesium intake and risk of type 2 diabetes: meta-analysis of prospective cohort studies
    Jia Yi Dong
    Department of Nutrition and Food Hygiene, Soochow University, Suzhou, China
    Diabetes Care 34:2116-22. 2011
    Emerging epidemiological evidence suggests that higher magnesium intake may reduce diabetes incidence...
  3. ncbi Fiber and magnesium intake and incidence of type 2 diabetes: a prospective study and meta-analysis
    Matthias B Schulze
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Arch Intern Med 167:956-65. 2007
    Prospective studies on fiber and magnesium intake and risk of type 2 diabetes mellitus were inconsistent...
  4. ncbi Structures and metal-ion-binding properties of the Ca2+-binding helix-loop-helix EF-hand motifs
    Jessica L Gifford
    Structural Biology Research Group, Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    Biochem J 405:199-221. 2007
    ..A structural approach is used in this review to examine the diversity of family members, and a biophysical perspective provides insight into the ability of the EF-hand motif to bind Ca2+ with a wide range of affinities...
  5. doi Metal ions in biological catalysis: from enzyme databases to general principles
    Claudia Andreini
    Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019, Sesto Fiorentino, Italy
    J Biol Inorg Chem 13:1205-18. 2008
    ..b>Magnesium and zinc are by far the most common ions of the first type, while calcium is relatively less used...
  6. pmc Ionomics: studying the social network of mineral nutrients
    Ivan Baxter
    Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA
    Curr Opin Plant Biol 12:381-6. 2009
    ..When combined with new genotyping technologies, ionomics provides a rapid way to identify genes that control elemental accumulation in plants...
  7. doi Crystal structure of a self-spliced group II intron
    Navtej Toor
    Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, Bass Building, New Haven, CT 06511, USA
    Science 320:77-82. 2008
    ..Structural and functional analogies support the hypothesis that group II introns and the spliceosome share a common ancestor...
  8. pmc Dissecting the influence of Mg2+ on 3D architecture and ligand-binding of the guanine-sensing riboswitch aptamer domain
    Janina Buck
    Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max von Laue Strasse 7 and 9, 60438 Frankfurt am Main, Germany
    Nucleic Acids Res 38:4143-53. 2010
    ..We propose that reduction of conformational dynamics in remote regions of the riboswitch aptamer domain is the minimal pre-requisite to pre-organize the core region for specific ligand binding...
  9. pmc Idiosyncratically tuned switching behavior of riboswitch aptamer domains revealed by comparative small-angle X-ray scattering analysis
    Nathan J Baird
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    RNA 16:598-609. 2010
    ..It is possible that the range of behaviors observed by SAXS, rather than being a biophysical idiosyncrasy, reflects adaptation of riboswitches to the regulatory requirements of their individual genomic context...
  10. pmc Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment
    S B Sartori
    Department of Pharmacology and Toxicology, Institute of Pharmacy, and Centre for Molecular Biosciences Innsbruck CMBI, University of Innsbruck, Peter Mayr Strasse 1, A 6020 Innsbruck, Austria
    Neuropharmacology 62:304-12. 2012
    Preclinical and some clinical studies suggest a relationship between perturbation in magnesium (Mg(2+)) homeostasis and pathological anxiety, although the underlying mechanisms remain largely unknown...
  11. ncbi Magnesium and its alloys as orthopedic biomaterials: a review
    Mark P Staiger
    Department of Mechanical Engineering, University of Canterbury, Private Bag 4800, Christchurch, New Zealand
    Biomaterials 27:1728-34. 2006
    ..roles in biological systems, and in vivo degradation via corrosion in the electrolytic environment of the body, magnesium-based implants have the potential to serve as biocompatible, osteoconductive, degradable implants for load-..
  12. ncbi Magnesium: nutrition and metabolism
    Jürgen Vormann
    Institute for Prevention and Nutrition, Osterfeldstr 92, D 85737, Ismaning, Germany
    Mol Aspects Med 24:27-37. 2003
    b>Magnesium is an essential mineral that is needed for a broad variety of physiological functions...
  13. ncbi Magnesium and diabetes mellitus: their relation
    Cristiane Hermes Sales
    Departamento de Nutricao, Universidade Federal do Rio Grande do Norte, UFRN, Centro de Ciencias da Saude, Av General Cordeiro de Farias, S N, Petropolis, Natal RN, 59010 180, Brazil
    Clin Nutr 25:554-62. 2006
    The aim of this review was to elaborate a synthesis about the discussions on magnesium and diabetes mellitus, in the last 14 years. The magnesium deficiency has been associated with chronic diseases, amongst them, diabetes mellitus...
  14. pmc Free state conformational sampling of the SAM-I riboswitch aptamer domain
    Colby D Stoddard
    Department of Chemistry and Biochemistry, University of Colorado at Boulder, UCB 215, Boulder, CO 80309 0215, USA
    Structure 18:787-97. 2010
    ..Our data reveal that the ligand binding domain adopts an ensemble of states that minimizes the energy barrier between the free and bound states to establish an efficient decision making branchpoint in the regulatory process...
  15. ncbi Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription
    Marcin Nowotny
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 28:264-76. 2007
    ..The region that accommodates this conformational change offers a target to develop HIV-specific inhibitors...
  16. doi Potassium, calcium, and magnesium intakes and risk of stroke in women
    Susanna C Larsson
    Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE 17177 Stockholm, Sweden
    Am J Epidemiol 174:35-43. 2011
    The authors examined the association between dietary potassium, calcium, and magnesium intakes and the incidence of stroke among 34,670 women 49-83 years of age in the Swedish Mammography Cohort who completed a food frequency ..
  17. ncbi Dietary magnesium intake in a national sample of US adults
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Nutr 133:2879-82. 2003
    Despite the role of magnesium in maintaining health, much of the U.S. population has historically not consumed adequate amounts of magnesium. Furthermore, significant racial or ethnic disparities in magnesium intake exist...
  18. doi Variation in intakes of calcium, phosphorus, magnesium, iron and potassium in 10 countries in the European Prospective Investigation into Cancer and Nutrition study
    A A Welch
    Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival, University of Cambridge, Cambridge, UK
    Eur J Clin Nutr 63:S101-21. 2009
    ..This study aimed at investigating variation in intakes of selected minerals across 10 European countries participating in the EPIC (European Prospective Investigation into Cancer and Nutrition) study...
  19. pmc RNA folding and catalysis mediated by iron (II)
    Shreyas S Athavale
    School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America
    PLoS ONE 7:e38024. 2012
    ..RNA and Fe²⁺ could, in principle, support an array of RNA structures and catalytic functions more diverse than RNA with Mg²⁺ alone...
  20. doi Hypomagnesaemia is associated with diabetes: Not pre-diabetes, obesity or the metabolic syndrome
    David Simmons
    Institute of Metabolic Science, Cambridge University Hospitals NHS Foundation Trust, UK
    Diabetes Res Clin Pract 87:261-6. 2010
    ..The mechanism for the association between diabetes and hypomagnesaemia remains uncertain. This study aimed to test whether hypomagnesaemia is present in pre-diabetes, obesity and the metabolic syndrome...
  21. doi In vitro corrosion and biocompatibility of binary magnesium alloys
    Xuenan Gu
    State Key Laboratory for Turbulence and Complex System and Department of Advanced Materials and Nanotechnology, College of Engineering, Peking University, Beijing 100871, China
    Biomaterials 30:484-98. 2009
    As bioabsorbable materials, magnesium alloys are expected to be totally degraded in the body and their biocorrosion products not deleterious to the surrounding tissues...
  22. pmc Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains
    Huanghe Yang
    Department of Biomedical Engineering, and Cardiac Bioelectricity and Arrhythmia Center, Washington University, 1 Brookings Drive, St Louis, Missouri 63130, USA
    Nat Struct Mol Biol 15:1152-9. 2008
    ..These results suggest that the VSD and the cytoplasmic domains from different subunits may interact during channel gating, and the packing of VSD or the RCK1 domain to the pore in BK channels differ from that in Kv1.2 or MthK channels...
  23. doi Level of trace elements (copper, zinc, magnesium and selenium) and toxic elements (lead and mercury) in the hair and nail of children with autism
    Malarveni Damodaran Lakshmi Priya
    Department of Biochemistry, Bharathi Women s College, Chennai, 600 108 Tamil Nadu, India
    Biol Trace Elem Res 142:148-58. 2011
    ..the purpose of the present study was to assess the levels of trace elements like copper (Cu), zinc (Zn), magnesium (Mg), and selenium (Se) and toxic elements like mercury (Hg), and lead (Pb) in the hair and nail samples of ..
  24. ncbi Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)
    J O Lee
    Laboratory of X ray Crystallography, Dana Farber Cancer Institute, Harvard Medical School Boston, Massachusetts 02115
    Cell 80:631-8. 1995
    ..Our crystal structure will allow reliable models to be built for other members of the A domain superfamily and should facilitate development of novel adhesion modulatory drugs...
  25. ncbi Hypomagnesemia in patients with type 2 diabetes
    Phuong Chi T Pham
    Olive View UCLA Medical Center, 14445 Olive View Drive, Department of Medicine, 2B 182, Nephrology Division, Sylmar, CA 91342, USA
    Clin J Am Soc Nephrol 2:366-73. 2007
    ..This article reviews the literature on the metabolism of magnesium, incidence of hypomagnesemia in patients with type 2 diabetes, implicated contributing factors, and associated ..
  26. pmc TRPM6 and TRPM7: A Mul-TRP-PLIK-cation of channel functions
    Loren W Runnels
    Department of Pharmacology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Curr Pharm Biotechnol 12:42-53. 2011
    ..Soon after their identification, the two proteins were quickly linked to the regulation of magnesium homeostasis...
  27. doi Vascular smooth muscle cell differentiation to an osteogenic phenotype involves TRPM7 modulation by magnesium
    Augusto C Montezano
    OHRI University of Ottawa, 451 Smyth Road, Ottawa, K1H 8M5 Ontario, Canada
    Hypertension 56:453-62. 2010
    ..Clinical studies suggest that magnesium may prevent this, but mechanisms are unclear...
  28. pmc Second messenger role for Mg2+ revealed by human T-cell immunodeficiency
    Feng Yen Li
    Molecular Development Section, Lymphocyte Molecular Genetics Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 475:471-6. 2011
    The magnesium ion, Mg(2+), is essential for all life as a cofactor for ATP, polyphosphates such as DNA and RNA, and metabolic enzymes, but whether it plays a part in intracellular signalling (as Ca(2+) does) is unknown...
  29. doi Evaluation of short-term effects of rare earth and other elements used in magnesium alloys on primary cells and cell lines
    Frank Feyerabend
    Department of Structural Research on Macromolecules, GKSS Research Centre, Institute for Materials Research, Max Planck Strasse 1, D 21502 Geesthacht, Germany
    Acta Biomater 6:1834-42. 2010
    Degradable magnesium alloys for biomedical application are on the verge of being used clinically. Rare earth elements (REEs) are used to improve the mechanical properties of the alloys, but in more or less undefined mixtures...
  30. doi Magnesium, inflammation, and obesity in chronic disease
    Forrest H Nielsen
    US Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, North Dakota 58202 9034, USA
    Nutr Rev 68:333-40. 2010
    About 60% of adults in the United States do not consume the estimated average requirement for magnesium, but widespread pathological conditions attributed to magnesium deficiency have not been reported...
  31. pmc The ligand-free state of the TPP riboswitch: a partially folded RNA structure
    Mona Ali
    Department of Applied Physics, Stanford University, Stanford, CA 94305, USA
    J Mol Biol 396:153-65. 2010
    ..Our results also demonstrate the power of combining experimental small-angle X-ray scattering data with theoretical structure prediction tools in the determination of RNA structures beyond riboswitches...
  32. ncbi Transient receptor potential melastatin 7 ion channels regulate magnesium homeostasis in vascular smooth muscle cells: role of angiotensin II
    Ying He
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Canada
    Circ Res 96:207-15. 2005
    b>Magnesium modulates vascular smooth muscle cell (VSMC) function. However, molecular mechanisms regulating VSMC Mg2+ remain unknown...
  33. pmc Dietary calcium and magnesium intakes and the risk of type 2 diabetes: the Shanghai Women's Health Study
    Raquel Villegas
    Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
    Am J Clin Nutr 89:1059-67. 2009
    ..Diet plays a key role in the development of type 2 diabetes (T2D), but little is known about the contributions of specific nutrients in populations in which dietary patterns differ from Western populations...
  34. pmc Parathyroid hormone, but not vitamin D, is associated with the metabolic syndrome in morbidly obese women and men: a cross-sectional study
    Jøran Hjelmesaeth
    Morbid Obesity Center, Vestfold Hospital Trust, Health Region South, Tønsberg, Norway
    Cardiovasc Diabetol 8:7. 2009
    ..Further, low serum levels of 25-hydroxyvitamin D (25 [OH]D) and magnesium have been associated with increased risk of the metabolic syndrome (MS), and recently, a possible link between ..
  35. pmc Mg2+ and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes
    David C Wrighton
    Centre for Neuroscience Research, Hugh Robson Building, University of Edinburgh, George Square, Edinburgh, UK
    J Physiol 586:211-25. 2008
    ..We suggest that the potency of block of NMDARs by Mg(2+) is influenced not only by pore-forming regions but also the LBD and the resulting conformational changes that occur following agonist binding...
  36. ncbi Glycemic index and dietary fiber and the risk of type 2 diabetes
    Allison M Hodge
    Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia
    Diabetes Care 27:2701-6. 2004
    ..To examine associations between type 2 diabetes and fiber, glycemic load (GL), dietary glycemic index (GI), and fiber-rich foods...
  37. pmc Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release
    Marcin Nowotny
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 25:1924-33. 2006
    ..Lastly, product release probably requires dissociation of metal ion A, which is inhibited by either high concentrations of divalent cations or mutation of an assisting protein residue...
  38. ncbi Structures of the bacterial ribosome at 3.5 A resolution
    Barbara S Schuwirth
    Department of Chemistry, University of California, Berkeley, CA 94720, USA
    Science 310:827-34. 2005
    ....
  39. ncbi Evaluation of the skin sensitizing potential of biodegradable magnesium alloys
    Frank Witte
    Department of Orthopaedic Surgery, Hannover Medical School, Hannover, Germany
    J Biomed Mater Res A 86:1041-7. 2008
    Corroding metals made of magnesium alloys represent a new class of degradable implants for musculoskeletal surgery. These implants may be associated with skin sensitizing reactions because of the release of metal ions...
  40. doi Cadmium toxicity revisited: focus on oxidative stress induction and interactions with zinc and magnesium
    Vesna Matovic
    Department of Toxicology Akademik Danilo Soldatović, Faculty of Pharmacy, University of Belgrade, Serbia
    Arh Hig Rada Toksikol 62:65-76. 2011
    ..gives a brief review of cadmium-induced oxidative stress and its interactions with essential elements zinc and magnesium as relevant mechanisms of cadmium toxicity...
  41. pmc Serum magnesium and risk of sudden cardiac death in the Atherosclerosis Risk in Communities (ARIC) Study
    James M Peacock
    University of Minnesota, Minneapolis, 55454, USA
    Am Heart J 160:464-70. 2010
    We hypothesized that serum magnesium (Mg) is associated with increased risk of sudden cardiac death (SCD).
  42. ncbi Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance
    Mario Barbagallo
    Institute of Internal Medicine and Geriatrics, University of Palermo, Italy
    Arch Biochem Biophys 458:40-7. 2007
    ....
  43. ncbi Magnesium sulfate for neuroprotection after traumatic brain injury: a randomised controlled trial
    Nancy R Temkin
    Department of Neurological Surgery, University of Washington, Seattle, USA
    Lancet Neurol 6:29-38. 2007
    Traumatic brain injuries represent an important and costly health problem. Supplemental magnesium positively affects many of the processes involved in secondary injury after traumatic brain injury and consistently improves outcome in ..
  44. pmc Magnesium fluctuations modulate RNA dynamics in the SAM-I riboswitch
    Ryan L Hayes
    Center for Theoretical Biological Physics and Department of Physics and Astronomy, Rice University, Houston, Texas 77005 1892, USA
    J Am Chem Soc 134:12043-53. 2012
    ..Rather than a few inner-sphere ions anchoring the RNA structure surrounded by a continuum of diffuse ions, we observe a layer of outer-sphere coordinated Mg(2+) that is transiently bound but strongly coupled to the RNA...
  45. doi Prevention of malathion-induced depletion of cardiac cells mitochondrial energy and free radical damage by a magnetic magnesium-carrying nanoparticle
    Hoda Shafiee
    Pharmaceutical Sciences Branch, Islamic Azad University
    Toxicol Mech Methods 20:538-43. 2010
    ....
  46. doi Dietary magnesium intake is related to metabolic syndrome in older Americans
    Nicola M McKeown
    Nutritional Epidemiology Department, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Eur J Nutr 47:210-6. 2008
    b>Magnesium (Mg) is an essential cofactor for enzymes involved in glucose and insulin metabolism. Low intakes of dietary magnesium may be linked to greater risk of metabolic syndrome (MS) in older adults.
  47. pmc Magnesium reduces calcification in bovine vascular smooth muscle cells in a dose-dependent manner
    Fatih Kircelli
    Division of Nephrology, Ege University School of Medicine, Izmir, Turkey
    Nephrol Dial Transplant 27:514-21. 2012
    ..In clinical studies, an inverse relationship between serum magnesium and VC has been reported...
  48. pmc Lack of association between serum magnesium and the risks of hypertension and cardiovascular disease
    Abigail May Khan
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am Heart J 160:715-20. 2010
    ..Prior clinical studies have yielded conflicting results but were limited by the use of self-reported magnesium intake or short follow-up periods.
  49. pmc Low serum magnesium and cardiovascular mortality in chronic heart failure: a propensity-matched study
    Chris Adamopoulos
    Papageorgiou General Hospital, Thessaloniki, Greece
    Int J Cardiol 136:270-7. 2009
    Low serum magnesium levels may cause fatal ventricular arrhythmias. However, their long-term effects on mortality and morbidity in chronic heart failure patients are relatively unknown.
  50. ncbi Skeletal and hormonal effects of magnesium deficiency
    Robert K Rude
    USC Keck School of Medicine, Los Angeles, CA, USA
    J Am Coll Nutr 28:131-41. 2009
    b>Magnesium (Mg) is the second most abundant intracellular cation where it plays an important role in enzyme function and trans-membrane ion transport...
  51. ncbi Intake of potassium, magnesium, calcium, and fiber and risk of stroke among US men
    A Ascherio
    Department of Nutrition, Epidemiology and Health and Social Behavior, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 98:1198-204. 1998
    ..Animal experiments and epidemiological studies have suggested that high potassium intake may reduce the risk of stroke, but the evidence is inconclusive, and the role of other nutrients in potassium-rich foods remains unknown...
  52. doi Impaired mitochondrial bioenergetics determines glutamate-induced delayed calcium deregulation in neurons
    Andrey Y Abramov
    Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3 BG, UK
    Biochim Biophys Acta 1800:297-304. 2010
    ..Exposure of neurons to toxic glutamate concentrations causes an initial transient increase in [Ca(2+)](c) followed by a delayed increase commonly termed delayed [Ca(2+)](c) deregulation (DCD)...
  53. ncbi Initial clinical experience of vasodilatory effect of intra-cisternal infusion of magnesium sulfate for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage
    Kentaro Mori
    Department of Neurosurgery, Juntendo University Shizuoka Hospital, 1129 Nagaoka, Izunokuni, Shizuoka, Japan
    Neurol Med Chir (Tokyo) 49:139-44; discussion 144-5. 2009
    The vasodilatory effect of intra-cisternal infusion of magnesium sulfate solution was evaluated in 10 patients with symptomatic vasospasm after aneurysmal subarachnoid hemorrhage (SAH) who underwent early clipping surgery...
  54. ncbi Initial evidence for the return of coronary vasoreactivity following the absorption of bioabsorbable magnesium alloy coronary stents
    Gopal Ghimire
    Royal Brompton and Harefield NHS Trust, Imperial College, London, United Kingdom
    EuroIntervention 4:481-4. 2009
    ..the endothelium independent coronary smooth muscle vasomotor function four months after implantation of magnesium alloy absorbable metal stents (AMS) as part of the Progress-AMS clinical trial (n = 5), compared with a control ..
  55. ncbi Role of magnesium in genomic stability
    A Hartwig
    Department of Food Chemistry and Toxicology, University of Karlsruhe, Profach 6980, D 76128, Karlsruhe, Germany
    Mutat Res 475:113-21. 2001
    In cellular systems, magnesium is the second most abundant element and is involved in basically all metabolic pathways...
  56. pmc A recurrent magnesium-binding motif provides a framework for the ribosomal peptidyl transferase center
    Chiaolong Hsiao
    School of Chemistry and Biochemistry, Parker H Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332 0400, USA
    Nucleic Acids Res 37:3134-42. 2009
    ..Here we demonstrate that the ribosomal peptidyl transferase center (PTC) is supported by a framework of magnesium microclusters (Mg(2+)-muc's)...
  57. pmc Single-molecule analysis of protein-free U2-U6 snRNAs
    Zhuojun Guo
    Department of Chemistry, Wayne State University, Detroit, Michigan, USA
    Nat Struct Mol Biol 16:1154-9. 2009
    ..The first step is strongly magnesium dependent, and we provide evidence suggesting that the second step corresponds to the formation of the ..
  58. doi Role of magnesium in alleviation of aluminium toxicity in plants
    Jayakumar Bose
    School of Earth and Environment, Faculty of Natural and Agricultural Sciences, University of Western Australia, Crawley WA 6009, Australia
    J Exp Bot 62:2251-64. 2011
    b>Magnesium is pivotal for activating a large number of enzymes; hence, magnesium plays an important role in numerous physiological and biochemical processes affecting plant growth and development...
  59. doi Relationship between magnesium and clinical biomarkers on inhibition of vascular calcification
    Silvia Salem
    Charite, Medical Clinic IV, University of Berlin, Germany
    Am J Nephrol 35:31-9. 2012
    ..This study focuses on the most likely protective effects of magnesium ion (Mg(2+)) on phosphate-induced vascular calcification ex vivo/in vitro...
  60. pmc A structural equation model for assessment of links between changes in serum triglycerides, -urate, and -glucose and changes in serum calcium, -magnesium and -phosphate in type 2 diabetes and non-diabetes metabolism
    Lena Håglin
    Department of Public Health and Clinical Medicine, Family Medicine, Umea University, SE 901 87 Umea, Sweden
    Cardiovasc Diabetol 10:116. 2011
    ..between changes in serum triglycerides (S-TG), -urate (S-Urate), and -glucose (S-Glu) and changes in serum calcium (S-Ca), -magnesium (S-Mg), and -phosphate (S-P) in patients with type 2 diabetes compared with non-diabetic patients.
  61. ncbi Permeant ion effects on external Mg2+ block of NR1/2D NMDA receptors
    Anqi Qian
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 26:10899-910. 2006
    ..Differences in the Mg2+(o) blocking site, and particularly in the selectivity filter and internal channel entrance, are principally responsible for the subunit dependence of Mg2+(o) block...
  62. pmc Structural transitions and thermodynamics of a glycine-dependent riboswitch from Vibrio cholerae
    Jan Lipfert
    Department of Physics, Stanford University, Stanford, CA 94305, USA
    J Mol Biol 365:1393-406. 2007
    ..We fit a simple three-state thermodynamic model that describes the energetic coupling between magnesium-induced folding and glycine binding...
  63. pmc Structural insights into ligand recognition by a sensing domain of the cooperative glycine riboswitch
    Lili Huang
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Cell 40:774-86. 2010
    ....
  64. doi The Saccharomyces cerevisiae PHM8 gene encodes a soluble magnesium-dependent lysophosphatidic acid phosphatase
    Venky Sreedhar Reddy
    Lipid Laboratory, Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India
    J Biol Chem 283:8846-54. 2008
    ..In vitro assays of the purified recombinant Phm8p revealed magnesium-dependent LPA phosphatase activity, with maximal activity at pH 6.5...
  65. ncbi Effects of magnesium supplementation in hypertensive patients: assessment by office, home, and ambulatory blood pressures
    Y Kawano
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
    Hypertension 32:260-5. 1998
    An increase in magnesium intake has been suggested to lower blood pressure (BP). However, the results of clinical studies are inconsistent...
  66. pmc Nonsense-mediated mRNA decay maintains translational fidelity by limiting magnesium uptake
    Marcus J O Johansson
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Genes Dev 24:1491-5. 2010
    ..that the reduced termination efficiency of NMD-deficient cells is attributable to increased expression of the magnesium transporter Alr1p and the resulting effects of elevated Mg(2+) levels on termination fidelity...
  67. pmc Discovering structural motifs using a structural alphabet: application to magnesium-binding sites
    Minko Dudev
    Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
    BMC Bioinformatics 8:106. 2007
    ..Our motif discovery method employs structural alphabet encoding to convert 3D structures to the corresponding 1D structural letter sequences, where the Mg2+-structural motifs are identified as recurring structural patterns...
  68. pmc The unique nature of mg2+ channels
    Andrea S Moomaw
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Physiology (Bethesda) 23:275-85. 2008
    ..Many questions about these channels remain, however, including the molecular basis of Mg2+ selectivity and the physiological role(s) of their eukaryotic homologs...
  69. ncbi Cell (patho)physiology of magnesium
    Federica I Wolf
    Istituto di Patologia generale e Centro di Ricerche Oncologiche Giovanni XXIII, Facolta di Medicina, Universita Cattolica del Sacro Cuore, Largo F Vito 1, 00168 Roma, Italy
    Clin Sci (Lond) 114:27-35. 2008
    There is an unsettled debate about the role of magnesium as a 'chronic regulator' of biological functions, as opposed to the well-known role for calcium as an 'acute regulator'...
  70. pmc Mrs2p forms a high conductance Mg2+ selective channel in mitochondria
    Rainer Schindl
    Institute for Biophysics, University of Linz, Linz, Austria
    Biophys J 93:3872-83. 2007
    ..We conclude that Mrs2p forms a high conductance Mg(2+) selective channel that controls Mg(2+) influx into mitochondria by an intrinsic negative feedback mechanism...
  71. ncbi Intrathecal magnesium prolongs fentanyl analgesia: a prospective, randomized, controlled trial
    Asokumar Buvanendran
    Department of Anesthesiology, Rush Medical College at Rush Presbyterian St Luke s Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA
    Anesth Analg 95:661-6, table of contents. 2002
    b>Magnesium is a noncompetitive, N-methyl-D-aspartate receptor antagonist that does not effectively cross the blood-brain barrier when given IV...
  72. ncbi Cisplatin nephrotoxicity affects magnesium and calcium metabolism
    Marshall P Goren
    Department of Urology, The University of Tennessee, Memphis, Tennessee, USA
    Med Pediatr Oncol 41:186-9. 2003
    Cisplatin is not directly toxic to bone, but cisplatin nephrotoxicity leading to magnesium wasting may affect magnesium and calcium metabolism, both of which contribute to bone integrity...
  73. ncbi Catalytic mechanism of NADP(+)-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexes
    J H Hurley
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0448
    Biochemistry 30:8671-8. 1991
    The structures of NADP+ and magnesium isocitrate bound to the NADP(+)-dependent isocitrate dehydrogenase of Escherichia coli have been determined and refined at 2.5-A resolution...
  74. pmc Dietary fiber, magnesium, and glycemic load alter risk of type 2 diabetes in a multiethnic cohort in Hawaii
    Beth N Hopping
    Department of Epidemiology, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    J Nutr 140:68-74. 2010
    The influence of dietary fiber, magnesium (Mg), and glycemic load (GL) on diabetes was examined in the Hawaii component of the Multiethnic Cohort...
  75. ncbi Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons
    Yasnory F Sasaki
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, California 92037, USA
    J Neurophysiol 87:2052-63. 2002
    ..Finally, a new longer splice variant of NR3A has been cloned and found to be expressed in rodent cortical neurons by single-cell RT-PCR and in situ hybridization...
  76. ncbi Magnesium and the inflammatory response: potential physiopathological implications
    Andrzej Mazur
    Equipe Stress Métabolique et Micronutriments, Unité de Nutrition Humaine UMR 1019, Centre de Recherche en Nutrition Humaine d Auvergne, INRA, Theix, St Genes Champanelle, France
    Arch Biochem Biophys 458:48-56. 2007
    The purpose of this review is to summarize experimental findings showing that magnesium modulates cellular events involved in inflammation...
  77. ncbi A tetracycline-binding RNA aptamer
    C Berens
    Institute of Microbiology and Genetics, Vienna Biocenter Dr. Bohrgasse 9/4, A-1030, Vienna, Austria
    Bioorg Med Chem 9:2549-56. 2001
    ..Binding of tetracycline to cb28 is magnesium dependent. The secondary structure of cb28 was determined by lead cleavage and DMS modification...
  78. ncbi Low serum magnesium levels and foot ulcers in subjects with type 2 diabetes
    M Rodriguez-Moran
    Unidad de Investigacion Medica en Epidemiologia Clinica, Hospital General, Instituto Mexicano del Seguro Social IMSS, Durango, Mexico
    Arch Med Res 32:300-3. 2001
    ..Thus, the aim of this study was to determine the relationship between low serum magnesium and foot ulcer in subjects with type 2 diabetes.
  79. ncbi A second magnesium ion is critical for ATP binding in the kinase domain of the oncoprotein v-Fps
    P Saylor
    Department of Chemistry, San Diego State University, California 92182 1030, USA
    Biochemistry 37:12624-30. 1998
    The activity of the kinase domain of the oncoprotein v-Fps was found to be sensitive to the concentration of magnesium ions...
  80. ncbi Hypomagnesemia and hypermagnesemia
    Joel Michels Topf
    University of Chicago, Chicago, IL 60615, USA
    Rev Endocr Metab Disord 4:195-206. 2003
  81. pmc Substrate discrimination in RNase P RNA-mediated cleavage: importance of the structural environment of the RNase P cleavage site
    Ema Kikovska
    Department of Cell and Molecular Biology Box 596, Biomedical Centre, SE 751 24 Uppsala, Sweden
    Nucleic Acids Res 33:2012-21. 2005
    ..Finally, we provide evidence that the structural architecture influences Mg2+ binding, most likely in its vicinity...
  82. ncbi Potentials of magnesium treatment in subarachnoid haemorrhage
    W M van den Bergh
    Department of Neurology, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands
    Magnes Res 17:301-13. 2004
    ..The interval between the bleeding and the onset of ischemia provides an opportunity for preventive treatment. Magnesium is readily available, inexpensive and has a well-established clinical profile in obstetrical and cardiovascular ..
  83. pmc PhoP-PhoQ activates transcription of pmrAB, encoding a two-component regulatory system involved in Salmonella typhimurium antimicrobial peptide resistance
    J S Gunn
    University of Washington, Seattle 98195, USA
    J Bacteriol 178:6857-64. 1996
    ..These data suggest that resistance to the polymyxin-CAP family is controlled by a cascade of regulatory protein expression that activates transcription upon environmental sensing...
  84. ncbi Magnesium deficiency and osteoporosis: animal and human observations
    Robert K Rude
    University of Southern California and the Orthopaedic Hospital, Los Angeles, CA 90089 9317, USA
    J Nutr Biochem 15:710-6. 2004
    ..elderly, there continues to be a need for well-designed clinical and animal studies on the link between dietary magnesium (Mg) intake and osteoporosis...
  85. doi Pseudomonas aeruginosa produces an extracellular deoxyribonuclease that is required for utilization of DNA as a nutrient source
    Heidi Mulcahy
    Department of Microbiology and Infectious Diseases, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada
    Environ Microbiol 12:1621-9. 2010
    ..aeruginosa that enables degradation of extracellular DNA into an accessible source of carbon, nitrogen and phosphate. DNase production by P. aeruginosa also has important implications for virulence and biofilm formation...
  86. pmc Free intracellular Mg(2+) concentration and inhibition of NMDA responses in cultured rat neurons
    Y Li-Smerin
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Physiol 533:729-43. 2001
    ..This differential effect of Mg(2+)(i) on channel gating explains why Mg(2+)(i) inhibits whole-cell NMDA responses less effectively than patch responses...
  87. ncbi Effect of Mg2+ on the DNA binding modes of the Streptococcus pneumoniae SsbA and SsbB proteins
    Diane E Grove
    Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    J Biol Chem 281:2087-94. 2006
    ..Additional experiments with a chimeric SsbA/B protein indicated that the structural determinants that govern the transitions between the different DNA binding modes may be contained within the N-terminal domains of the SSB proteins...
  88. ncbi Dictyostelium myosin-IE is a fast molecular motor involved in phagocytosis
    Ulrike Dürrwang
    Abteilung Biophysik, Max Planck Institut fur medizinische Forschung, Jahnstr 29, 69120 Heidelberg, Germany
    J Cell Sci 119:550-8. 2006
    ..Changes in the level of free Mg(2+) ions, which are within the physiological range, are shown to modulate the motor activity of myosin-IE by inhibiting the release of adenosine diphosphate...
  89. ncbi Magnesium intake and risk of type 2 diabetes: a meta-analysis
    S C Larsson
    Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 262:208-14. 2007
    To assess the association between magnesium intake and risk of type 2 diabetes.
  90. pmc Metal-ion binding and metal-ion induced folding of the adenine-sensing riboswitch aptamer domain
    Jonas Noeske
    Department of Biochemistry, The University of Texas Health Science Center San Antonio, San Antonio, TX 78229, USA
    Nucleic Acids Res 35:5262-73. 2007
    ..Compared to the highly similar guanine-sensing riboswitch, the folding pathway for the adenine-sensing riboswitch aptamer domain is more complex and the influence of Mg2+ is more pronounced...
  91. ncbi Principles of RNA compaction: insights from the equilibrium folding pathway of the P4-P6 RNA domain in monovalent cations
    Keiji Takamoto
    Department of Physiology and Biophysics, Albert Einstein College of Medicine of Yeshiva University, New York, NY 10461, USA
    J Mol Biol 343:1195-206. 2004
    ..The folding model derived from these and previous results provides a robust framework for understanding the equilibrium and kinetic folding of RNA...
  92. pmc Crystal structure of the lysine riboswitch regulatory mRNA element
    Andrew D Garst
    Department of Chemistry and Biochemistry, University of Colorado, Boulder, Boulder, Colorado 80309, USA
    J Biol Chem 283:22347-51. 2008
    ....
  93. pmc Contribution of the PhoP-PhoQ and PmrA-PmrB two-component regulatory systems to Mg2+-induced gene regulation in Pseudomonas aeruginosa
    Joseph B McPhee
    Department of Microbiology and Immunology and Centre for Microbial Diseases and Immunity Research, University of British Columbia, 232 2259 Lower Mall, Vancouver, BC, Canada V6T 1Z4
    J Bacteriol 188:3995-4006. 2006
    ..The number of known PmrA-regulated genes was expanded to include the PA1559-PA1560, PA4782-PA4781, and feoAB operons, in addition to the previously known PA4773-PA4775-pmrAB and pmrHFIJKLM-ugd operons...
  94. ncbi Glycogen synthase kinase-3 inhibition by lithium and beryllium suggests the presence of two magnesium binding sites
    W Jonathan Ryves
    MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
    Biochem Biophys Res Commun 290:967-72. 2002
    Lithium inhibits (Li(+)) glycogen synthase kinase-3 (GSK-3) by competition for magnesium (Mg(2+)), but not ATP or substrate...
  95. pmc RNA folding: thermodynamic and molecular descriptions of the roles of ions
    David E Draper
    Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Biophys J 95:5489-95. 2008
    ....
  96. ncbi The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter
    G Zsurka
    Vienna Biocenter, Department of Microbiology and Genetics, University of Vienna, Dr Bohrgasse 9, Vienna, A 1030, Austria
    Genomics 72:158-68. 2001
    ..on the human MRS2 gene that encodes a protein, hsaMrs2p, the first molecularly characterized candidate for a magnesium transporter in metazoa...
  97. ncbi The yeast plasma membrane protein Alr1 controls Mg2+ homeostasis and is subject to Mg2+-dependent control of its synthesis and degradation
    A Graschopf
    Vienna Biocenter, Institute of Microbiology and Genetics, University of Vienna, A-1030 Vienna, Austria
    J Biol Chem 276:16216-22. 2001
    ..The results are discussed in terms of Alr1p being a plasma membrane transporter with high selectivity for Mg(2+)...
  98. pmc Mrs2p is an essential component of the major electrophoretic Mg2+ influx system in mitochondria
    Martin Kolisek
    Vienna Biocenter, Institute of Microbiology and Genetics, University of Vienna, Dr Bohrgasse, A 1030 Vienna, Austria
    EMBO J 22:1235-44. 2003
    ..Taken together, these findings characterize Mrs2p as the first molecularly identified metal ion channel protein in the inner mitochondrial membrane...
  99. ncbi The inward rectification mechanism of the HERG cardiac potassium channel
    P L Smith
    Department of Neurobiology, Harvard Medical School, Boston, MA 02114 2698, USA
    Nature 379:833-6. 1996
    ..The characteristics of this gating suggest a specific role for this channel in the normal suppression of arrhythmias...
  100. pmc The SAL1 gene of Arabidopsis, encoding an enzyme with 3'(2'),5'-bisphosphate nucleotidase and inositol polyphosphate 1-phosphatase activities, increases salt tolerance in yeast
    F J Quintero
    Departamento de Biotecnologia, Universidad Politecnica de Madrid, Spain
    Plant Cell 8:529-37. 1996
    ..We propose that the product of SAL1 participates in the sulfur assimilation pathway as well as in the phosphoinositide signaling pathway and that changes in the latter may affect Na+ and Li+ fluxes...
  101. pmc Drosophila TRPM channel is essential for the control of extracellular magnesium levels
    Thomas Hofmann
    Institut fur Pharmakologie und Toxikologie, Philipps Universitat Marburg, Marburg, Germany
    PLoS ONE 5:e10519. 2010
    ..These data provide the first evidence for a role for a Drosophila TRP channel in Mg2+ homeostasis, and underscore a broad and evolutionarily conserved role for TRPM channels in Mg2+ homeostasis...

Research Grants74

  1. MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMA
    H Winn; Fiscal Year: 2001
    ..Using a randomized, double-blind design, the present study will evaluate magnesium sulfate as a neuroprotectant and anti-epileptogenic agent following head injury...
  2. MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMA
    Nancy Temkin; Fiscal Year: 2004
    ..of moderate or severe head injury the ongoing trial tests whether these consequence can be ameliorated by magnesium sulfate...
  3. Sodium and Cardiovascular Disease in Patients with Chronic Kidney Disease
    Jiang He; Fiscal Year: 2009
    ..between dietary intake of sodium, potassium (estimated from multiple 24-hour urinary excretion), calcium, and magnesium (estimated from multiple food frequency questionnaires [FFQ]) and the risk of clinical CVD (including coronary ..
  4. Prevention of neointimal thickening by Mst1
    Junichi Sadoshima; Fiscal Year: 2006
    ..delivery of Mst1 from stents, we will utilize completely biodegradable stents made of noncombustible magnesium and a proprietary technique to coat the stents with mammalian expression plasmids, which can be efficiently ..
  5. Characterizing RNA-metal binding by Raman spectroscopy
    Paul Carey; Fiscal Year: 2009
    ..b>Magnesium binding sites in the crystal structures that have been characterized by X-ray crystallography are being used to ..
  6. Characterizing RNA-metal binding by Raman spectroscopy
    Paul R Carey; Fiscal Year: 2010
    ..b>Magnesium binding sites in the crystal structures that have been characterized by X-ray crystallography are being used to ..
  7. Sodium and Cardiovascular Disease in Patients with Chronic Kidney Disease
    Jiang He; Fiscal Year: 2010
    ..between dietary intake of sodium, potassium (estimated from multiple 24-hour urinary excretion), calcium, and magnesium (estimated from multiple food frequency questionnaires [FFQ]) and the risk of clinical CVD (including coronary ..
  8. RISK FACTORS FOR AGED RELATED BONE LOSS
    Douglas Kiel; Fiscal Year: 2000
    ..and the effect on bone loss of specific nutrients that have not been well-studied with regard to bone, including magnesium, potassium, vitamin C, sodium, and vitamin K...
  9. Structural Basis for Bridged Bimetallic Enzyme Catalysis
    Dagmar Ringe; Fiscal Year: 2009
    ..A large percentage of those contain two metal ions (usually first-row transition metals or magnesium) connected by a bridging ligand (usually a carboxylate group)...
  10. Structural Basis for Bridged Bimetallic Enzyme Catalysis
    Dagmar Ringe; Fiscal Year: 2007
    ..A large percentage of those contain two metal ions (usually first-row transition metals or magnesium) connected by a bridging ligand (usually a carboxylate group)...
  11. COMPREHENSIVE SICKLE CELL CENTER
    Winfred Wang; Fiscal Year: 2006
    ..chemotherapy" for reducing the frequency of pain crises through a Phase III trial of hydroxyurea and magnesium vs. hydroxyurea and placebo in pediatric and adult patients...
  12. Dietary Calcium and Magnesium, Genetics, and Colorectal Adenoma
    Qi Dai; Fiscal Year: 2009
    ..in the Tennessee Colorectal Polyp Study (TCPS; P50CA95103) that the associations between intake of calcium or magnesium and risk of colorectal adenoma and hyperplastic polyps may differ by the common Thr1482Ile polymorphism of the ..
  13. Dietary Calcium and Magnesium, Genetics, and Colorectal Adenoma
    Qi Dai; Fiscal Year: 2010
    ..in the Tennessee Colorectal Polyp Study (TCPS;P50CA95103) that the associations between intake of calcium or magnesium and risk of colorectal adenoma and hyperplastic polyps may differ by the common Thr1482Ile polymorphism of the ..
  14. Structural basis of tetracycline resistance by efflux pump TetL
    Da Neng Wang; Fiscal Year: 2010
    ..is mediated by membrane transporter proteins that catalyze efflux of tetracyclines in the form of tetracycline-magnesium complex. The structural basis for substrate recognition by such efflux proteins is poorly understood...
  15. Psychophysics of Divalent Salts and Metallic Taste
    HARRY LAWLESS; Fiscal Year: 2006
    ..of the period table including calcium, an active participant in various steps of taste transduction, as well as magnesium and barium...
  16. Magnesium's Antihypertensive Effects in Preeclampsia
    CYNTHIA STANDLEY; Fiscal Year: 2003
    ..b>Magnesium sulfate is the standard treatment for preeclampsia...
  17. Aldosteron, Intracellular Leukocyte Magnesium and Inflammation in Diabetes
    Jose R Romero; Fiscal Year: 2010
    ..stimulates Na+/Mg2+ exchange activity in isolated human leukocytes leading to a decrease in intracellular magnesium and an increase in expression of pro-inflammatory factors...
  18. Aldosteron, Intracellular Leukocyte Magnesium and Inflammation in Diabetes
    Jose Romero; Fiscal Year: 2009
    ..stimulates Na+/Mg2+ exchange activity in isolated human leukocytes leading to a decrease in intracellular magnesium and an increase in expression of pro-inflammatory factors...
  19. INDOMETHACIN FOR ADJUVANT TOCOLYSIS
    George Macones; Fiscal Year: 2004
    ..b>Magnesium sulfate is currently the most commonly prescribed agent for tocolysis in the United States...