magnesium

..Our study not only provided the descriptive data but also implied the balance or homeostasis of these monovalent and divalent cations in their muscle pools...

..A general two-metal ion mechanism is widely accepted to account for the biophysical and biochemical data thus far available...

..b>Magnesium and zinc are by far the most common ions of the first type, while calcium is relatively less used...

..We propose that reduction of conformational dynamics in remote regions of the riboswitch aptamer domain is the minimal pre-requisite to pre-organize the core region for specific ligand binding...

..Structural and functional analogies support the hypothesis that group II introns and the spliceosome share a common ancestor...

..It is possible that the range of behaviors observed by SAXS, rather than being a biophysical idiosyncrasy, reflects adaptation of riboswitches to the regulatory requirements of their individual genomic context...

..Our data reveal that the ligand binding domain adopts an ensemble of states that minimizes the energy barrier between the free and bound states to establish an efficient decision making branchpoint in the regulatory process...

The purpose of this review is to summarize experimental findings showing that magnesium modulates cellular events involved in inflammation...

Degradable magnesium alloys for biomedical application are on the verge of being used clinically. Rare earth elements (REEs) are used to improve the mechanical properties of the alloys, but in more or less undefined mixtures...

..Our results also demonstrate the power of combining experimental small-angle X-ray scattering data with theoretical structure prediction tools in the determination of RNA structures beyond riboswitches...

About 60% of adults in the United States do not consume the estimated average requirement for magnesium, but widespread pathological conditions attributed to magnesium deficiency have not been reported...

..Our crystal structure will allow reliable models to be built for other members of the A domain superfamily and should facilitate development of novel adhesion modulatory drugs...

..Further, low serum levels of 25-hydroxyvitamin D (25 [OH]D) and magnesium have been associated with increased risk of the metabolic syndrome (MS), and recently, a possible link between ..

An increase in magnesium intake has been suggested to lower blood pressure (BP). However, the results of clinical studies are inconsistent...

..When combined with new genotyping technologies, ionomics provides a rapid way to identify genes that control elemental accumulation in plants...

..Our motif discovery method employs structural alphabet encoding to convert 3D structures to the corresponding 1D structural letter sequences, where the Mg2+-structural motifs are identified as recurring structural patterns...

..Differences in the Mg2+(o) blocking site, and particularly in the selectivity filter and internal channel entrance, are principally responsible for the subunit dependence of Mg2+(o) block...

..We fit a simple three-state thermodynamic model that describes the energetic coupling between magnesium-induced folding and glycine binding...

..In vitro assays of the purified recombinant Phm8p revealed magnesium-dependent LPA phosphatase activity, with maximal activity at pH 6.5...

..We suggest that the potency of block of NMDARs by Mg(2+) is influenced not only by pore-forming regions but also the LBD and the resulting conformational changes that occur following agonist binding...

..that the reduced termination efficiency of NMD-deficient cells is attributable to increased expression of the magnesium transporter Alr1p and the resulting effects of elevated Mg(2+) levels on termination fidelity...

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Prospective studies on fiber and magnesium intake and risk of type 2 diabetes mellitus were inconsistent...

..We conclude that Mrs2p forms a high conductance Mg(2+) selective channel that controls Mg(2+) influx into mitochondria by an intrinsic negative feedback mechanism...

..Many questions about these channels remain, however, including the molecular basis of Mg2+ selectivity and the physiological role(s) of their eukaryotic homologs...

There is an unsettled debate about the role of magnesium as a 'chronic regulator' of biological functions, as opposed to the well-known role for calcium as an 'acute regulator'...

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..This differential effect of Mg(2+)(i) on channel gating explains why Mg(2+)(i) inhibits whole-cell NMDA responses less effectively than patch responses...

..The number of known PmrA-regulated genes was expanded to include the PA1559-PA1560, PA4782-PA4781, and feoAB operons, in addition to the previously known PA4773-PA4775-pmrAB and pmrHFIJKLM-ugd operons...

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..The folding model derived from these and previous results provides a robust framework for understanding the equilibrium and kinetic folding of RNA...

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Lithium inhibits (Li(+)) glycogen synthase kinase-3 (GSK-3) by competition for magnesium (Mg(2+)), but not ATP or substrate...

..The interval between the bleeding and the onset of ischemia provides an opportunity for preventive treatment. Magnesium is readily available, inexpensive and has a well-established clinical profile in obstetrical and cardiovascular ..

..aeruginosa that enables degradation of extracellular DNA into an accessible source of carbon, nitrogen and phosphate. DNase production by P. aeruginosa also has important implications for virulence and biofilm formation...

..Finally, we provide evidence that the structural architecture influences Mg2+ binding, most likely in its vicinity...

..The region that accommodates this conformational change offers a target to develop HIV-specific inhibitors...

To assess the association between magnesium intake and risk of type 2 diabetes.

..These data suggest that resistance to the polymyxin-CAP family is controlled by a cascade of regulatory protein expression that activates transcription upon environmental sensing...

..Additional experiments with a chimeric SsbA/B protein indicated that the structural determinants that govern the transitions between the different DNA binding modes may be contained within the N-terminal domains of the SSB proteins...

..Compared to the highly similar guanine-sensing riboswitch, the folding pathway for the adenine-sensing riboswitch aptamer domain is more complex and the influence of Mg2+ is more pronounced...

..elderly, there continues to be a need for well-designed clinical and animal studies on the link between dietary magnesium (Mg) intake and osteoporosis...

..Changes in the level of free Mg(2+) ions, which are within the physiological range, are shown to modulate the motor activity of myosin-IE by inhibiting the release of adenosine diphosphate...

..Taken together, these findings characterize Mrs2p as the first molecularly identified metal ion channel protein in the inner mitochondrial membrane...

..on the human MRS2 gene that encodes a protein, hsaMrs2p, the first molecularly characterized candidate for a magnesium transporter in metazoa...

..The results are discussed in terms of Alr1p being a plasma membrane transporter with high selectivity for Mg(2+)...

..The characteristics of this gating suggest a specific role for this channel in the normal suppression of arrhythmias...

..We propose that the product of SAL1 participates in the sulfur assimilation pathway as well as in the phosphoinositide signaling pathway and that changes in the latter may affect Na+ and Li+ fluxes...

..However, there is scant information on how magnesium status is affected by RYGBP surgery...

..These data provide the first evidence for a role for a Drosophila TRP channel in Mg2+ homeostasis, and underscore a broad and evolutionarily conserved role for TRPM channels in Mg2+ homeostasis...

b>Magnesium (Mg) ions directly influence vascular tone and responsiveness and are cofactors for acetylcholine-induced endothelium-dependent relaxation...

..CONCLUSIONS: Ca/Mg infusions seem to reduce incidence and intensity of acute oxaliplatin-induced symptoms and might delay cumulative neuropathy, especially in 85 mg/m(2) oxaliplatin dosage...

b>Magnesium (Mg) is the second most abundant intracellular cation where it plays an important role in enzyme function and trans-membrane ion transport...

Today, more than 200years after the first production of metallic magnesium by Sir Humphry Davy in 1808, biodegradable magnesium-based metal implants are currently breaking the paradigm in biomaterial science to develop only highly ..

..These results revealed that Mg(2+) might have dual effects on PARN stability: protecting the active site but endangering the overall structural stability...

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..The combination of NMR and bioinformatic approaches presented here has identified a novel RNA fold and provides insights into the structural basis of catalytic function in the Neurospora VS ribozyme...

..Binding of tetracycline to cb28 is magnesium dependent. The secondary structure of cb28 was determined by lead cleavage and DMS modification...

A recent prospective study among Swedish women suggested an inverse association of dietary magnesium intake with incidence of colorectal cancer...

..These alterations may contribute to an enhancement of NMDA responses at hyperpolarized membrane potentials that may be a key factor in striatal neuronal dysfunction...

..These assays also show that both the N-terminus and C-terminus of Alr1p and Alr2p are exposed to the inner side of the plasma membrane...

Mean magnesium intake in the US population does not differ from that in East Asian populations with traditionally low risks of colorectal cancer and other chronic diseases, but the ratio of calcium to magnesium (Ca:Mg) intake is much ..

..Under optimum pH and Mg(2+) conditions this ribozyme cleaves at over 870 min(-1) at 25 degrees C, further demonstrating the impressive catalytic power of this ribozyme...

..This study aimed to evaluate the association of serum and hair levels of calcium and magnesium with BMD in premenopausal women.

Because magnesium blocks the N-methyl-D-aspartate receptor and its associated ion channels, it can prevent central sensitization caused by peripheral nociceptive stimulation...

..Serum magnesium (mmol/L) level was measured by the original kits of Abbott Aeroset auto-analyzer...

We investigated the long-term effects of maternal/postnatal magnesium (Mg) restriction on adiposity, glucose tolerance, and insulin secretion in the offspring and the probable biochemical mechanisms associated with them.

..Aspects of these results that have broader implications for a range of channel and transporter families are highlighted...

b>Magnesium accumulates at high concentrations in dicotyledonous leaves but it is not known in which leaf cell types it accumulates, by what mechanism this occurs and the role it plays when stored in the vacuoles of these cell types...

..This study was carried out to analyze and to compare the concentration of calcium, magnesium, and zinc in the serum of women with pre-eclampsia and in normal pregnant women...

..This study reports the early transcriptomic response to magnesium (Mg) deprivation in Arabidopsis...

b>Magnesium is a noncompetitive, N-methyl-D-aspartate receptor antagonist that does not effectively cross the blood-brain barrier when given IV...

Zinc and magnesium are potent inhibitors of the N-methyl-D-aspartate (NMDA) receptor complex...

..This is consistent with the current view of the probable mechanism of trans-esterification in which adenine and guanine nucleobases contributed by the interacting loops combine in general acid-base catalysis...

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It has been shown that the activity of the hammerhead ribozyme at microM magnesium ion concentrations is markedly increased by the inclusion of loops in helices I and II...

..This strain contained mutations in at least two loci in addition to corA, designated mgtA and mgtB (for magnesium transport)...

..serine/threonine phosphatase of type 2C that is highly affected in its activity by changes in the proton and magnesium ion concentrations...

..The cocrystal structure with stem-loop DNA illustrates how this family of transposases specifically recognizes and pairs ends, necessary steps during transposition...

..Here we report that the antioxidant agents vitamins A, C, and E act in synergy with magnesium to effectively prevent noise-induced trauma...

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..To identify the causative mineral(s), the effect of magnesium restriction was assessed...

b>Magnesium deficiency has been associated with insulin resistance (IR) and increased risk for type 2 diabetes in adults...

The goal of this study was to examine the mechanism of magnesium binding to the regulatory domain of skeletal troponin C (TnC)...

..9307-9314) we demonstrated that DNA strand exchange can occur in the presence of volume-occupying agents at low magnesium ion concentration, where secondary structures are reduced...

..There are evidences suggesting that magnesium is a crucial constituent of the blood coagulation cascade and has a pro-coagulant activity...

The antidepressant- and anxiolytic-like effects of magnesium, an N-methyl-d-aspartate (NMDA) glutamate receptor inhibitor, were studied in mice using the forced swim test and elevated plus-maze test, respectively...

A few previous studies have looked at the relationship between pregnancy outcome and magnesium nutritional intake and found that magnesium supplementation which could have beneficial effects on perinatal outcome...

..Unlike the Ca2(+)-ATPases, however, which mediate efflux of cation from the cytosol, MgtB mediates influx of cation into the cytosol...

The mass-dense granules of Dictyostelium discoideum were shown to contain large amounts of phosphorus, magnesium, and calcium, as determined by x-ray microanalysis, either in situ or when purified using iodixanol gradient centrifugation...

..Our results indicate that higher concentrations of free Mg(2+) ions stabilize the tension-bearing actin myosin ADP state and shift the system from the production of rapid movement toward the generation of tension...

b>Magnesium is the fourth most abundant cation in the body and plays an important physiological role in many of its functions. It plays a fundamental role as a cofactor in various enzymatic reactions involving energy metabolism...

..Mean contents of 1.22 x 10(3), 93, 85, 54, 11, 1.9 and 2.3 mg/kg were found, respectively, for K+, Ca2+, Na+, Mg2+, Mn2+, Ni2+ and Li+ cations in analysed honeys. These results were similar than the obtained by other authors...

..These results provide the first insight into the dynamics of nucleotide binding and substrate-induced conformational changes at the active site of a protein histidine kinase...

..The objective of this work was to diagnose and to determine the prevalence of metabolic disorders, to assess the quality of the water consumed and volume of diuresis as potential risk factors for this pathology...

..Dimensional alteration test for both cements were greater than values considered acceptable by ANSI/ADA. Epiphany values regarding solubility were also greater than values considered acceptable by ANSI/ADA...

..Equimolar concentrations of ATP and magnesium ions display a behavior similar to that described for ATP concentration in Mg(2+) saturating condition (high ..

..These results contribute to a quantitative characterization of the Na+-Mg2+ exchange in cardiac myocytes...

..Results showed that risk was over- or underestimated using the CaCl(2) medium in soils with a markedly different soil solution composition...

..Peanut facilitated P nutrition of maize and barley, while maize and barley improved K, Fe, Zn and Mn nutrition of peanut grown in nutrient-poor saline-sodic and B toxic soil...

..However, the introduction of molasses to the diet can contribute to an adequate intake of these elements...

..Using a randomized, double-blind design, the present study will evaluate magnesium sulfate as a neuroprotectant and anti-epileptogenic agent following head injury...

..of moderate or severe head injury the ongoing trial tests whether these consequence can be ameliorated by magnesium sulfate...

..between dietary intake of sodium, potassium (estimated from multiple 24-hour urinary excretion), calcium, and magnesium (estimated from multiple food frequency questionnaires [FFQ]) and the risk of clinical CVD (including coronary ..

..between dietary intake of sodium, potassium (estimated from multiple 24-hour urinary excretion), calcium, and magnesium (estimated from multiple food frequency questionnaires [FFQ]) and the risk of clinical CVD (including coronary ..

..delivery of Mst1 from stents, we will utilize completely biodegradable stents made of noncombustible magnesium and a proprietary technique to coat the stents with mammalian expression plasmids, which can be efficiently ..

..b>Magnesium binding sites in the crystal structures that have been characterized by X-ray crystallography are being used to ..

..b>Magnesium binding sites in the crystal structures that have been characterized by X-ray crystallography are being used to ..

..and the effect on bone loss of specific nutrients that have not been well-studied with regard to bone, including magnesium, potassium, vitamin C, sodium, and vitamin K...

..A large percentage of those contain two metal ions (usually first-row transition metals or magnesium) connected by a bridging ligand (usually a carboxylate group)...

..A large percentage of those contain two metal ions (usually first-row transition metals or magnesium) connected by a bridging ligand (usually a carboxylate group)...

..chemotherapy" for reducing the frequency of pain crises through a Phase III trial of hydroxyurea and magnesium vs. hydroxyurea and placebo in pediatric and adult patients...

..in the Tennessee Colorectal Polyp Study (TCPS; P50CA95103) that the associations between intake of calcium or magnesium and risk of colorectal adenoma and hyperplastic polyps may differ by the common Thr1482Ile polymorphism of the ..

..in the Tennessee Colorectal Polyp Study (TCPS;P50CA95103) that the associations between intake of calcium or magnesium and risk of colorectal adenoma and hyperplastic polyps may differ by the common Thr1482Ile polymorphism of the ..

..is mediated by membrane transporter proteins that catalyze efflux of tetracyclines in the form of tetracycline-magnesium complex. The structural basis for substrate recognition by such efflux proteins is poorly understood...

..of the period table including calcium, an active participant in various steps of taste transduction, as well as magnesium and barium...

..b>Magnesium sulfate is the standard treatment for preeclampsia...

..stimulates Na+/Mg2+ exchange activity in isolated human leukocytes leading to a decrease in intracellular magnesium and an increase in expression of pro-inflammatory factors...

..stimulates Na+/Mg2+ exchange activity in isolated human leukocytes leading to a decrease in intracellular magnesium and an increase in expression of pro-inflammatory factors...

..b>Magnesium sulfate is currently the most commonly prescribed agent for tocolysis in the United States...