magnesium

Summary

Summary: A light, silvery, metallic element. It has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. Its salts are essential in nutrition, being required for the activity of many enzymes, especially those concerned with oxidative phosphorylation. It is a component of both intra- and extracellular fluids and is excreted in the urine and feces. Deficiency causes irritability of the nervous system with tetany, vasodilation, convulsions, tremors, depression, and psychotic behavior. (From Dorland, 27th ed)

Top Publications

  1. ncbi Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis
    Marcin Nowotny
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 121:1005-16. 2005
  2. pmc Magnesium intake and risk of type 2 diabetes: meta-analysis of prospective cohort studies
    Jia Yi Dong
    Department of Nutrition and Food Hygiene, Soochow University, Suzhou, China
    Diabetes Care 34:2116-22. 2011
  3. pmc A general two-metal-ion mechanism for catalytic RNA
    T A Steitz
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511
    Proc Natl Acad Sci U S A 90:6498-502. 1993
  4. ncbi Structure of the 70S ribosome complexed with mRNA and tRNA
    Maria Selmer
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Science 313:1935-42. 2006
  5. ncbi Magnesium and its alloys as orthopedic biomaterials: a review
    Mark P Staiger
    Department of Mechanical Engineering, University of Canterbury, Private Bag 4800, Christchurch, New Zealand
    Biomaterials 27:1728-34. 2006
  6. ncbi Crystal structure of a self-spliced group II intron
    Navtej Toor
    Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, Bass Building, New Haven, CT 06511, USA
    Science 320:77-82. 2008
  7. ncbi Structures and metal-ion-binding properties of the Ca2+-binding helix-loop-helix EF-hand motifs
    Jessica L Gifford
    Structural Biology Research Group, Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    Biochem J 405:199-221. 2007
  8. ncbi Metal ions in biological catalysis: from enzyme databases to general principles
    Claudia Andreini
    Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019, Sesto Fiorentino, Italy
    J Biol Inorg Chem 13:1205-18. 2008
  9. pmc Second messenger role for Mg2+ revealed by human T-cell immunodeficiency
    Feng Yen Li
    Molecular Development Section, Lymphocyte Molecular Genetics Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 475:471-6. 2011
  10. ncbi Fiber and magnesium intake and incidence of type 2 diabetes: a prospective study and meta-analysis
    Matthias B Schulze
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Arch Intern Med 167:956-65. 2007

Detail Information

Publications384 found, 100 shown here

  1. ncbi Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis
    Marcin Nowotny
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 121:1005-16. 2005
    ..In transposases, they are symmetrically coordinated and exchange roles to alternately activate a water and a 3'-OH for successive strand cleavage and transfer by a ping-pong mechanism...
  2. pmc Magnesium intake and risk of type 2 diabetes: meta-analysis of prospective cohort studies
    Jia Yi Dong
    Department of Nutrition and Food Hygiene, Soochow University, Suzhou, China
    Diabetes Care 34:2116-22. 2011
    Emerging epidemiological evidence suggests that higher magnesium intake may reduce diabetes incidence...
  3. pmc A general two-metal-ion mechanism for catalytic RNA
    T A Steitz
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511
    Proc Natl Acad Sci U S A 90:6498-502. 1993
    ..The role of the RNA is to position the two catalytic metal ions and properly orient the substrates via three specific binding sites...
  4. ncbi Structure of the 70S ribosome complexed with mRNA and tRNA
    Maria Selmer
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Science 313:1935-42. 2006
    ..The interactions of E-site tRNA with the 50S subunit have both similarities and differences compared to those in the archaeal ribosome. The structure also rationalizes much biochemical and genetic data on translation...
  5. ncbi Magnesium and its alloys as orthopedic biomaterials: a review
    Mark P Staiger
    Department of Mechanical Engineering, University of Canterbury, Private Bag 4800, Christchurch, New Zealand
    Biomaterials 27:1728-34. 2006
    ..roles in biological systems, and in vivo degradation via corrosion in the electrolytic environment of the body, magnesium-based implants have the potential to serve as biocompatible, osteoconductive, degradable implants for load-..
  6. ncbi Crystal structure of a self-spliced group II intron
    Navtej Toor
    Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, Bass Building, New Haven, CT 06511, USA
    Science 320:77-82. 2008
    ..Structural and functional analogies support the hypothesis that group II introns and the spliceosome share a common ancestor...
  7. ncbi Structures and metal-ion-binding properties of the Ca2+-binding helix-loop-helix EF-hand motifs
    Jessica L Gifford
    Structural Biology Research Group, Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    Biochem J 405:199-221. 2007
    ..A structural approach is used in this review to examine the diversity of family members, and a biophysical perspective provides insight into the ability of the EF-hand motif to bind Ca2+ with a wide range of affinities...
  8. ncbi Metal ions in biological catalysis: from enzyme databases to general principles
    Claudia Andreini
    Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019, Sesto Fiorentino, Italy
    J Biol Inorg Chem 13:1205-18. 2008
    ..b>Magnesium and zinc are by far the most common ions of the first type, while calcium is relatively less used...
  9. pmc Second messenger role for Mg2+ revealed by human T-cell immunodeficiency
    Feng Yen Li
    Molecular Development Section, Lymphocyte Molecular Genetics Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 475:471-6. 2011
    The magnesium ion, Mg(2+), is essential for all life as a cofactor for ATP, polyphosphates such as DNA and RNA, and metabolic enzymes, but whether it plays a part in intracellular signalling (as Ca(2+) does) is unknown...
  10. ncbi Fiber and magnesium intake and incidence of type 2 diabetes: a prospective study and meta-analysis
    Matthias B Schulze
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Arch Intern Med 167:956-65. 2007
    Prospective studies on fiber and magnesium intake and risk of type 2 diabetes mellitus were inconsistent...
  11. ncbi Associations of dietary magnesium intake with mortality from cardiovascular disease: the JACC study
    Wen Zhang
    Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan
    Atherosclerosis 221:587-95. 2012
    The authors sought to investigate the relationship between dietary magnesium intake and mortality from cardiovascular disease in a population-based sample of Asian adults...
  12. pmc Ionomics: studying the social network of mineral nutrients
    Ivan Baxter
    Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA
    Curr Opin Plant Biol 12:381-6. 2009
    ..When combined with new genotyping technologies, ionomics provides a rapid way to identify genes that control elemental accumulation in plants...
  13. pmc Dissecting the influence of Mg2+ on 3D architecture and ligand-binding of the guanine-sensing riboswitch aptamer domain
    Janina Buck
    Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max von Laue Strasse 7 and 9, 60438 Frankfurt am Main, Germany
    Nucleic Acids Res 38:4143-53. 2010
    ..We propose that reduction of conformational dynamics in remote regions of the riboswitch aptamer domain is the minimal pre-requisite to pre-organize the core region for specific ligand binding...
  14. ncbi Multiple regulatory sites in large-conductance calcium-activated potassium channels
    Xiao Ming Xia
    Department of Anesthesiology, Washington University School of Medicine, Box 8054, St Louis, Missouri 63110, USA
    Nature 418:880-4. 2002
    ..This allows BK channels to serve a variety of physiological roles contingent on the Ca(2+) concentration to which the channels are exposed...
  15. pmc Idiosyncratically tuned switching behavior of riboswitch aptamer domains revealed by comparative small-angle X-ray scattering analysis
    Nathan J Baird
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    RNA 16:598-609. 2010
    ..It is possible that the range of behaviors observed by SAXS, rather than being a biophysical idiosyncrasy, reflects adaptation of riboswitches to the regulatory requirements of their individual genomic context...
  16. ncbi The inward rectification mechanism of the HERG cardiac potassium channel
    P L Smith
    Department of Neurobiology, Harvard Medical School, Boston, MA 02114 2698, USA
    Nature 379:833-6. 1996
    ..The characteristics of this gating suggest a specific role for this channel in the normal suppression of arrhythmias...
  17. pmc Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel
    Yunkun Wu
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9040, USA
    Nature 466:393-7. 2010
    ....
  18. ncbi Dietary calcium and magnesium intake and mortality: a prospective study of men
    Joanna Kaluza
    Division of Nutritional Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Am J Epidemiol 171:801-7. 2010
    The authors examined the association of dietary calcium and magnesium intake with all-cause, cardiovascular disease (CVD), and cancer mortality among 23,366 Swedish men, aged 45-79 years, who did not use dietary supplements...
  19. ncbi Potassium, calcium, and magnesium intakes and risk of stroke in women
    Susanna C Larsson
    Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE 17177 Stockholm, Sweden
    Am J Epidemiol 174:35-43. 2011
    The authors examined the association between dietary potassium, calcium, and magnesium intakes and the incidence of stroke among 34,670 women 49-83 years of age in the Swedish Mammography Cohort who completed a food frequency ..
  20. ncbi Dietary magnesium intake and risk of stroke: a meta-analysis of prospective studies
    Susanna C Larsson
    Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Stockholm, Sweden
    Am J Clin Nutr 95:362-6. 2012
    Prospective studies of dietary magnesium intake in relation to risk of stroke have yielded inconsistent results.
  21. pmc Dietary calcium and magnesium intakes and the risk of type 2 diabetes: the Shanghai Women's Health Study
    Raquel Villegas
    Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
    Am J Clin Nutr 89:1059-67. 2009
    ..Diet plays a key role in the development of type 2 diabetes (T2D), but little is known about the contributions of specific nutrients in populations in which dietary patterns differ from Western populations...
  22. pmc Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment
    S B Sartori
    Department of Pharmacology and Toxicology, Institute of Pharmacy, and Centre for Molecular Biosciences Innsbruck CMBI, University of Innsbruck, Peter Mayr Strasse 1, A 6020 Innsbruck, Austria
    Neuropharmacology 62:304-12. 2012
    Preclinical and some clinical studies suggest a relationship between perturbation in magnesium (Mg(2+)) homeostasis and pathological anxiety, although the underlying mechanisms remain largely unknown...
  23. pmc Accessibility of 18S rRNA in human 40S subunits and 80S ribosomes at physiological magnesium ion concentrations--implications for the study of ribosome dynamics
    Christina L Shenvi
    Department of Chemistry, University of California, 202 Melvin Calvin Lab, Berkeley, CA 94720, USA
    RNA 11:1898-908. 2005
    ..The structural core of the ribosome is composed of RNA and is therefore dependent on counterions such as magnesium ions for function...
  24. ncbi Magnesium: nutrition and metabolism
    Jürgen Vormann
    Institute for Prevention and Nutrition, Osterfeldstr 92, D 85737, Ismaning, Germany
    Mol Aspects Med 24:27-37. 2003
    b>Magnesium is an essential mineral that is needed for a broad variety of physiological functions...
  25. pmc Free state conformational sampling of the SAM-I riboswitch aptamer domain
    Colby D Stoddard
    Department of Chemistry and Biochemistry, University of Colorado at Boulder, UCB 215, Boulder, CO 80309 0215, USA
    Structure 18:787-97. 2010
    ..Our data reveal that the ligand binding domain adopts an ensemble of states that minimizes the energy barrier between the free and bound states to establish an efficient decision making branchpoint in the regulatory process...
  26. ncbi Magnesium and diabetes mellitus: their relation
    Cristiane Hermes Sales
    Departamento de Nutricao, Universidade Federal do Rio Grande do Norte, UFRN, Centro de Ciencias da Saude, Av General Cordeiro de Farias, S N, Petropolis, Natal RN, 59010 180, Brazil
    Clin Nutr 25:554-62. 2006
    The aim of this review was to elaborate a synthesis about the discussions on magnesium and diabetes mellitus, in the last 14 years. The magnesium deficiency has been associated with chronic diseases, amongst them, diabetes mellitus...
  27. ncbi Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7
    Carsten Schmitz
    Department of Pediatrics, University of Washington and Children s Hospital and Regional Medical Center, Seattle, WA 98195, USA
    Cell 114:191-200. 2003
    ..Overall, our results indicate that TRPM7 has a central role in Mg(2+) homeostasis as a Mg(2+) uptake pathway regulated through a functional coupling between its channel and kinase domains...
  28. ncbi Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription
    Marcin Nowotny
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 28:264-76. 2007
    ..The region that accommodates this conformational change offers a target to develop HIV-specific inhibitors...
  29. ncbi Effects of restraint stress on iron, zinc, calcium, and magnesium whole blood levels in mice
    Wen Feng Teng
    College of Medical Laboratory, Dalian Medical University, Dalian, China
    Biol Trace Elem Res 121:243-8. 2008
    Study the effects of acute and chronic restraint stress on the whole blood concentrations of iron (Fe), zinc (Zn), calcium (Ca), and magnesium (Mg) in mice.
  30. ncbi Dietary magnesium intake and the future risk of coronary heart disease (the Honolulu Heart Program)
    Robert D Abbott
    Division of Biostatistics and Epidemiology, Department of Health Evaluation Sciences, University of Virginia School of Medicine, PO Box 800717, Charlottesville, VA 22908 0717, USA
    Am J Cardiol 92:665-9. 2003
    b>Magnesium (Mg) deficiency is believed to have adverse cardiovascular consequences that are broad and complex, although an association between dietary Mg intake and the risk of coronary heart disease (CHD) has not been clearly identified...
  31. pmc Serum magnesium and risk of sudden cardiac death in the Atherosclerosis Risk in Communities (ARIC) Study
    James M Peacock
    University of Minnesota, Minneapolis, 55454, USA
    Am Heart J 160:464-70. 2010
    We hypothesized that serum magnesium (Mg) is associated with increased risk of sudden cardiac death (SCD).
  32. ncbi The history of biodegradable magnesium implants: a review
    Frank Witte
    Laboratory for Biomechanics and Biomaterials, Department of Orthopaedic Surgery, Hannover Medical School, Anna von Borries Str 1 7, 30625 Hannover, Germany
    Acta Biomater 6:1680-92. 2010
    Today, more than 200years after the first production of metallic magnesium by Sir Humphry Davy in 1808, biodegradable magnesium-based metal implants are currently breaking the paradigm in biomaterial science to develop only highly ..
  33. pmc Magnesium-cationic dummy atom molecules enhance representation of DNA polymerase beta in molecular dynamics simulations: improved accuracy in studies of structural features and mutational effects
    Peter Oelschlaeger
    University of Southern California, Department of Chemistry, Los Angeles, CA 90089 1062, USA
    J Mol Biol 366:687-701. 2007
    ..Here, we present a magnesium-cationic dummy atom approach that can easily be implemented in molecular mechanical force fields such as the ..
  34. ncbi Persistent synchronized bursting activity in cortical tissues with low magnesium concentration: a modeling study
    David Golomb
    Department of Physiology, Faculty of Health Sciences, Ben Gurion University, Be er Sheva, Israel
    J Neurophysiol 95:1049-67. 2006
    ..bursting activity with frequency of approximately 10 Hz that appears in cortical tissues at low extracellular magnesium concentration [Mg2+]o...
  35. ncbi Low serum magnesium concentrations predict cardiovascular and all-cause mortality
    Thorsten Reffelmann
    Klinik und Poliklinik für Innere Medizin B, Universitätsklinikum der Ernst Moritz Arndt Universität Greifswald, Friedrich Löffler Str 23 a, 17487 Greifswald, Germany
    Atherosclerosis 219:280-4. 2011
    Low serum magnesium (Mg(++)) levels are associated with future development of left ventricular hypertrophy independently of common cardiovascular risk factors, as recently demonstrated in the five-year follow-up of the population-based ..
  36. ncbi Oral magnesium supplementation inhibits platelet-dependent thrombosis in patients with coronary artery disease
    M Shechter
    Preventive and Rehabilitative Cardiac Center, Cedars Sinai Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Am J Cardiol 84:152-6. 1999
    The use of magnesium in the treatment of acute myocardial infarction remains controversial despite preliminary experimental evidence that magnesium plays a beneficial role as a regulator of thrombosis...
  37. ncbi Magnesium inhibits spontaneous and iron-induced aggregation of alpha-synuclein
    Natalie Golts
    Department of Pharmacology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Biol Chem 277:16116-23. 2002
    ..For example, in Parkinson's disease, iron levels are increased and magnesium levels are reduced in the brains of patients...
  38. pmc TRPM7 channel is regulated by magnesium nucleotides via its kinase domain
    Philippe Demeuse
    Laboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen s Medical Center and John A Burns School of Medicine at the University of Hawaii, Honolulu, 96813, USA
    J Gen Physiol 127:421-34. 2006
    ..To obtain insight into these issues, we have determined the effect of purine and pyrimidine magnesium nucleotides on TRPM7 currents and investigated the possible involvement of the channel's kinase domain in ..
  39. ncbi Hypomagnesemia in patients with type 2 diabetes
    Phuong Chi T Pham
    Olive View UCLA Medical Center, 14445 Olive View Drive, Department of Medicine, 2B 182, Nephrology Division, Sylmar, CA 91342, USA
    Clin J Am Soc Nephrol 2:366-73. 2007
    ..This article reviews the literature on the metabolism of magnesium, incidence of hypomagnesemia in patients with type 2 diabetes, implicated contributing factors, and associated ..
  40. pmc Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains
    Huanghe Yang
    Department of Biomedical Engineering, and Cardiac Bioelectricity and Arrhythmia Center, Washington University, 1 Brookings Drive, St Louis, Missouri 63130, USA
    Nat Struct Mol Biol 15:1152-9. 2008
    ..These results suggest that the VSD and the cytoplasmic domains from different subunits may interact during channel gating, and the packing of VSD or the RCK1 domain to the pore in BK channels differ from that in Kv1.2 or MthK channels...
  41. ncbi Variation in intakes of calcium, phosphorus, magnesium, iron and potassium in 10 countries in the European Prospective Investigation into Cancer and Nutrition study
    A A Welch
    Department of Public Health and Primary Care, MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival, University of Cambridge, Cambridge, UK
    Eur J Clin Nutr 63:S101-21. 2009
    ..This study aimed at investigating variation in intakes of selected minerals across 10 European countries participating in the EPIC (European Prospective Investigation into Cancer and Nutrition) study...
  42. ncbi Level of trace elements (copper, zinc, magnesium and selenium) and toxic elements (lead and mercury) in the hair and nail of children with autism
    Malarveni Damodaran Lakshmi Priya
    Department of Biochemistry, Bharathi Women s College, Chennai, 600 108 Tamil Nadu, India
    Biol Trace Elem Res 142:148-58. 2011
    ..the purpose of the present study was to assess the levels of trace elements like copper (Cu), zinc (Zn), magnesium (Mg), and selenium (Se) and toxic elements like mercury (Hg), and lead (Pb) in the hair and nail samples of ..
  43. ncbi Dietary magnesium intake in a national sample of US adults
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Nutr 133:2879-82. 2003
    Despite the role of magnesium in maintaining health, much of the U.S. population has historically not consumed adequate amounts of magnesium. Furthermore, significant racial or ethnic disparities in magnesium intake exist...
  44. ncbi Vascular smooth muscle cell differentiation to an osteogenic phenotype involves TRPM7 modulation by magnesium
    Augusto C Montezano
    OHRI University of Ottawa, 451 Smyth Road, Ottawa, K1H 8M5 Ontario, Canada
    Hypertension 56:453-62. 2010
    ..Clinical studies suggest that magnesium may prevent this, but mechanisms are unclear...
  45. pmc RNA folding and catalysis mediated by iron (II)
    Shreyas S Athavale
    School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America
    PLoS ONE 7:e38024. 2012
    ..RNA and Fe²⁺ could, in principle, support an array of RNA structures and catalytic functions more diverse than RNA with Mg²⁺ alone...
  46. pmc TRPM6 and TRPM7: A Mul-TRP-PLIK-cation of channel functions
    Loren W Runnels
    Department of Pharmacology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Curr Pharm Biotechnol 12:42-53. 2011
    ..Soon after their identification, the two proteins were quickly linked to the regulation of magnesium homeostasis...
  47. pmc The ligand-free state of the TPP riboswitch: a partially folded RNA structure
    Mona Ali
    Department of Applied Physics, Stanford University, Stanford, CA 94305, USA
    J Mol Biol 396:153-65. 2010
    ..Our results also demonstrate the power of combining experimental small-angle X-ray scattering data with theoretical structure prediction tools in the determination of RNA structures beyond riboswitches...
  48. ncbi Evaluation of short-term effects of rare earth and other elements used in magnesium alloys on primary cells and cell lines
    Frank Feyerabend
    Department of Structural Research on Macromolecules, GKSS Research Centre, Institute for Materials Research, Max Planck Strasse 1, D 21502 Geesthacht, Germany
    Acta Biomater 6:1834-42. 2010
    Degradable magnesium alloys for biomedical application are on the verge of being used clinically. Rare earth elements (REEs) are used to improve the mechanical properties of the alloys, but in more or less undefined mixtures...
  49. ncbi Magnesium, inflammation, and obesity in chronic disease
    Forrest H Nielsen
    US Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, North Dakota 58202 9034, USA
    Nutr Rev 68:333-40. 2010
    About 60% of adults in the United States do not consume the estimated average requirement for magnesium, but widespread pathological conditions attributed to magnesium deficiency have not been reported...
  50. ncbi Interplay between an AAA module and an integrin I domain may regulate the function of magnesium chelatase
    M N Fodje
    Department of Molecular Biophysics, Lund University, Lund, 221 00, Sweden
    J Mol Biol 311:111-22. 2001
    ..into protoporphyrin IX is catalysed in an ATP-dependent reaction by a three-subunit (BchI, BchD and BchH) enzyme magnesium chelatase. In this work we present the three-dimensional structure of the ATP-binding subunit BchI...
  51. ncbi Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family
    Karl P Schlingmann
    Department of Pediatrics, Philipps University of Marburg, Deutschhausstrasse 12, D 35037 Marburg, Germany
    Nat Genet 31:166-70. 2002
    b>Magnesium is an essential ion involved in many biochemical and physiological processes. Homeostasis of magnesium levels is tightly regulated and depends on the balance between intestinal absorption and renal excretion...
  52. pmc Dietary fiber, magnesium, and glycemic load alter risk of type 2 diabetes in a multiethnic cohort in Hawaii
    Beth N Hopping
    Department of Epidemiology, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    J Nutr 140:68-74. 2010
    The influence of dietary fiber, magnesium (Mg), and glycemic load (GL) on diabetes was examined in the Hawaii component of the Multiethnic Cohort...
  53. ncbi Transient receptor potential melastatin 7 ion channels regulate magnesium homeostasis in vascular smooth muscle cells: role of angiotensin II
    Ying He
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Canada
    Circ Res 96:207-15. 2005
    b>Magnesium modulates vascular smooth muscle cell (VSMC) function. However, molecular mechanisms regulating VSMC Mg2+ remain unknown...
  54. pmc Parathyroid hormone, but not vitamin D, is associated with the metabolic syndrome in morbidly obese women and men: a cross-sectional study
    Jøran Hjelmesaeth
    Morbid Obesity Center, Vestfold Hospital Trust, Health Region South, Tønsberg, Norway
    Cardiovasc Diabetol 8:7. 2009
    ..Further, low serum levels of 25-hydroxyvitamin D (25 [OH]D) and magnesium have been associated with increased risk of the metabolic syndrome (MS), and recently, a possible link between ..
  55. ncbi Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)
    J O Lee
    Laboratory of X ray Crystallography, Dana Farber Cancer Institute, Harvard Medical School Boston, Massachusetts 02115
    Cell 80:631-8. 1995
    ..Our crystal structure will allow reliable models to be built for other members of the A domain superfamily and should facilitate development of novel adhesion modulatory drugs...
  56. pmc Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development
    Hao Zhou
    Department of Cardiology, Howard Hughes Medical Institute, Manton Center for Orphan Disease, Children s Hospital Boston, and Harvard Medical School, 1309 Enders, 320 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:15750-5. 2009
    b>Magnesium (Mg(2+)) is the second most abundant cation in cells, yet relatively few mechanisms have been identified that regulate cellular levels of this ion. The most clearly identified Mg(2+) transporters are in bacteria and yeast...
  57. ncbi In vitro corrosion and biocompatibility of binary magnesium alloys
    Xuenan Gu
    State Key Laboratory for Turbulence and Complex System and Department of Advanced Materials and Nanotechnology, College of Engineering, Peking University, Beijing 100871, China
    Biomaterials 30:484-98. 2009
    As bioabsorbable materials, magnesium alloys are expected to be totally degraded in the body and their biocorrosion products not deleterious to the surrounding tissues...
  58. ncbi Magnesium intake and risk of type 2 diabetes in men and women
    Ruy Lopez-Ridaura
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Diabetes Care 27:134-40. 2004
    To examine the association between magnesium intake and risk of type 2 diabetes.
  59. ncbi In vivo corrosion of four magnesium alloys and the associated bone response
    F Witte
    Department of Orthopaedic Surgery, Hannover Medical School, Anna von Borries Str 1 7, 30625 Hannover, Germany
    Biomaterials 26:3557-63. 2005
    ..of this study was to investigate the degradation mechanism at the bone-implant interface of different degrading magnesium alloys in bone and to determine their effect on the surrounding bone...
  60. pmc Magnesium intake in relation to systemic inflammation, insulin resistance, and the incidence of diabetes
    Dae Jung Kim
    Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Diabetes Care 33:2604-10. 2010
    To investigate the long-term associations of magnesium intake with incidence of diabetes, systemic inflammation, and insulin resistance among young American adults.
  61. ncbi Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia
    Roxanne Y Walder
    Department of Pediatrics and Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa 52242, USA
    Nat Genet 31:171-4. 2002
    ..The disorder has been thought to be caused by a defect in the intestinal absorption of magnesium, rather than by abnormal renal loss of magnesium...
  62. ncbi Glycemic index and dietary fiber and the risk of type 2 diabetes
    Allison M Hodge
    Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia
    Diabetes Care 27:2701-6. 2004
    ..To examine associations between type 2 diabetes and fiber, glycemic load (GL), dietary glycemic index (GI), and fiber-rich foods...
  63. pmc Mg2+ and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes
    David C Wrighton
    Centre for Neuroscience Research, Hugh Robson Building, University of Edinburgh, George Square, Edinburgh, UK
    J Physiol 586:211-25. 2008
    ..We suggest that the potency of block of NMDARs by Mg(2+) is influenced not only by pore-forming regions but also the LBD and the resulting conformational changes that occur following agonist binding...
  64. pmc Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release
    Marcin Nowotny
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 25:1924-33. 2006
    ..Lastly, product release probably requires dissociation of metal ion A, which is inhibited by either high concentrations of divalent cations or mutation of an assisting protein residue...
  65. ncbi Structures of the bacterial ribosome at 3.5 A resolution
    Barbara S Schuwirth
    Department of Chemistry, University of California, Berkeley, CA 94720, USA
    Science 310:827-34. 2005
    ....
  66. ncbi Silencing TRPM7 mimics the effects of magnesium deficiency in human microvascular endothelial cells
    Erika Baldoli
    Dipartimento di Scienze Cliniche Luigi Sacco, Universita di Milano, Via GB Grassi, 74, 20157 Milano, Italy
    Angiogenesis 15:47-57. 2012
    Evidence has accumulated to suggest that magnesium might play a role in controlling angiogenesis...
  67. ncbi Elevation of brain magnesium prevents and reverses cognitive deficits and synaptic loss in Alzheimer's disease mouse model
    Wei Li
    Tsinghua Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing 100084, China
    J Neurosci 33:8423-41. 2013
    ..Our previous work demonstrated that the magnesium ion is a critical factor in controlling synapse density/plasticity...
  68. pmc Effect of external magnesium and calcium on human connexin46 hemichannels
    Lisa Ebihara
    Department of Physiology and Biophysics, Finch University of Health Sciences, North Chicago, Illinois 60064, USA
    Biophys J 84:277-86. 2003
    ..Increasing extracellular magnesium resulted in a shift of the voltage dependence of activation to more positive potentials, a decrease in the ..
  69. ncbi Phosphorylation of annexin I by TRPM7 channel-kinase
    Maxim V Dorovkov
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 279:50643-6. 2004
    ..It has been shown that TRPM7 plays a key role in the regulation of intracellular magnesium homeostasis as well as in anoxic neuronal death...
  70. pmc Natural and synthetic modulators of SK (K(ca)2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7
    V Chubanov
    Walther Straub Institute of Pharmacology and Toxicology, University of Munich, Munich, Germany
    Br J Pharmacol 166:1357-76. 2012
    ..The goal of this work was to identify non-toxic inhibitors of the TRPM7 channel and to assess the effect of blocking endogenous TRPM7 currents on the phenotype of living cells...
  71. pmc Neutralizing mutations of carboxylates that bind metal 2 in T5 flap endonuclease result in an enzyme that still requires two metal ions
    Christopher G Tomlinson
    Centre for Chemical Biology, Department of Chemistry, Krebs Institute, University of Sheffield, Sheffield S3 7HF, United Kingdom
    J Biol Chem 286:30878-87. 2011
    ..Combined analyses imply that M2 is not involved in chemical catalysis but plays a role in substrate binding, and thus a two-metal ion mechanism is plausible...
  72. ncbi Intake of dietary magnesium and the prevalence of the metabolic syndrome among U.S. adults
    Earl S Ford
    Centers for Disease Control and Prevention, 4770 Buford Highway, MS K66, Atlanta, GA 30341, USA
    Obesity (Silver Spring) 15:1139-46. 2007
    Limited data suggest that people with the metabolic syndrome have lower intakes or circulating concentrations of magnesium than those who do not have the syndrome...
  73. pmc Molecular basis of epithelial Ca2+ and Mg2+ transport: insights from the TRP channel family
    Henrik Dimke
    Department of Physiology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Physiol 589:1535-42. 2011
    ..Dysregulation of either channel impacts the renal reabsorptive capacity for these cations. This review summarizes the current knowledge related to TRP channels in epithelial Ca(2+) and Mg(2+) transport...
  74. ncbi Magnesium and calcium organophyllosilicates: synthesis and in vitro cytotoxicity study
    Hyo Kyung Han
    College of Pharmacy, Dongguk University, Pil Dong, 3 Ga, Jung Gu, Seoul, Republic of Korea
    ACS Appl Mater Interfaces 3:2564-72. 2011
    ..For this, aminopropyl functionalized magnesium phyllosilicate (AMP clay) and aminopropyl functionalized calcium phyllosilicate (ACP clay) were prepared using ..
  75. ncbi Magnesium intake and incidence of metabolic syndrome among young adults
    Ka He
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Circulation 113:1675-82. 2006
    Studies suggest that magnesium intake may be inversely related to risk of hypertension and type 2 diabetes mellitus and that higher intake of magnesium may decrease blood triglycerides and increase high-density lipoprotein (HDL) ..
  76. pmc Distinct modulations of human capsaicin receptor by protons and magnesium through different domains
    Shu Wang
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 285:11547-56. 2010
    ..TRPV1 (hTRPV1), a species ortholog with high homology to rTRPV1, is potentiated by extracellular protons and magnesium, even at saturating capsaicin...
  77. ncbi Human gene SLC41A1 encodes for the Na+/Mg²+ exchanger
    Martin Kolisek
    Institute for Veterinary Physiology, Freie Universitat Berlin, Berlin, Germany
    Am J Physiol Cell Physiol 302:C318-26. 2012
    b>Magnesium (Mg(2+)), the second most abundant divalent intracellular cation, is involved in the vast majority of intracellular processes, including the synthesis of nucleic acids, proteins, and energy metabolism...
  78. ncbi The role of magnesium in hypertension and cardiovascular disease
    Mark Houston
    Division of Human Nutrition, Saint Thomas Medical Group and Hospital, Vanderbilt University School of Medicine, Hypertension Institute, Nashville, TN, USA
    J Clin Hypertens (Greenwich) 13:843-7. 2011
    b>Magnesium intake of 500 mg/d to 1000 mg/d may reduce blood pressure (BP) as much as 5.6/2.8 mm Hg. However, clinical studies have a wide range of BP reduction, with some showing no change in BP...
  79. ncbi A biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implants
    Hoi Man Wong
    Department of Orthopaedics and Traumatology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Biomaterials 31:2084-96. 2010
    b>Magnesium and its alloys may potentially be applied as degradable metallic materials in orthopaedic implantations due to their degradability and resemblance to human cortical bone...
  80. ncbi Hypomagnesaemia is associated with diabetes: Not pre-diabetes, obesity or the metabolic syndrome
    David Simmons
    Institute of Metabolic Science, Cambridge University Hospitals NHS Foundation Trust, UK
    Diabetes Res Clin Pract 87:261-6. 2010
    ..The mechanism for the association between diabetes and hypomagnesaemia remains uncertain. This study aimed to test whether hypomagnesaemia is present in pre-diabetes, obesity and the metabolic syndrome...
  81. ncbi Deep-sea water improves cardiovascular hemodynamics in Kurosawa and Kusanagi-Hypercholesterolemic (KHC) rabbits
    Shin Ichiro Katsuda
    Department of Cellular and Integrative Physiology, Fukushima Medical University School of Medicine, Fukushima 960 1295, Japan
    Biol Pharm Bull 31:38-44. 2008
    ..From our results, we conclude that deep-sea water could improve cardiovascular hemodynamics, even though the factors which affect the blood pressure are still unknown...
  82. ncbi Evaluation of the skin sensitizing potential of biodegradable magnesium alloys
    Frank Witte
    Department of Orthopaedic Surgery, Hannover Medical School, Hannover, Germany
    J Biomed Mater Res A 86:1041-7. 2008
    Corroding metals made of magnesium alloys represent a new class of degradable implants for musculoskeletal surgery. These implants may be associated with skin sensitizing reactions because of the release of metal ions...
  83. ncbi Cadmium toxicity revisited: focus on oxidative stress induction and interactions with zinc and magnesium
    Vesna Matovic
    Department of Toxicology Akademik Danilo Soldatović, Faculty of Pharmacy, University of Belgrade, Serbia
    Arh Hig Rada Toksikol 62:65-76. 2011
    ..gives a brief review of cadmium-induced oxidative stress and its interactions with essential elements zinc and magnesium as relevant mechanisms of cadmium toxicity...
  84. ncbi Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance
    Mario Barbagallo
    Institute of Internal Medicine and Geriatrics, University of Palermo, Italy
    Arch Biochem Biophys 458:40-7. 2007
    ....
  85. ncbi Dietary magnesium intake is related to metabolic syndrome in older Americans
    Nicola M McKeown
    Nutritional Epidemiology Department, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Eur J Nutr 47:210-6. 2008
    b>Magnesium (Mg) is an essential cofactor for enzymes involved in glucose and insulin metabolism. Low intakes of dietary magnesium may be linked to greater risk of metabolic syndrome (MS) in older adults.
  86. ncbi Prevention of malathion-induced depletion of cardiac cells mitochondrial energy and free radical damage by a magnetic magnesium-carrying nanoparticle
    Hoda Shafiee
    Pharmaceutical Sciences Branch, Islamic Azad University
    Toxicol Mech Methods 20:538-43. 2010
    ....
  87. ncbi Magnesium sulfate for neuroprotection after traumatic brain injury: a randomised controlled trial
    Nancy R Temkin
    Department of Neurological Surgery, University of Washington, Seattle, USA
    Lancet Neurol 6:29-38. 2007
    Traumatic brain injuries represent an important and costly health problem. Supplemental magnesium positively affects many of the processes involved in secondary injury after traumatic brain injury and consistently improves outcome in ..
  88. pmc Magnesium reduces calcification in bovine vascular smooth muscle cells in a dose-dependent manner
    Fatih Kircelli
    Division of Nephrology, Ege University School of Medicine, Izmir, Turkey
    Nephrol Dial Transplant 27:514-21. 2012
    ..In clinical studies, an inverse relationship between serum magnesium and VC has been reported...
  89. pmc Lack of association between serum magnesium and the risks of hypertension and cardiovascular disease
    Abigail May Khan
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am Heart J 160:715-20. 2010
    ..Prior clinical studies have yielded conflicting results but were limited by the use of self-reported magnesium intake or short follow-up periods.
  90. pmc Magnesium fluctuations modulate RNA dynamics in the SAM-I riboswitch
    Ryan L Hayes
    Center for Theoretical Biological Physics and Department of Physics and Astronomy, Rice University, Houston, Texas 77005 1892, USA
    J Am Chem Soc 134:12043-53. 2012
    ..Rather than a few inner-sphere ions anchoring the RNA structure surrounded by a continuum of diffuse ions, we observe a layer of outer-sphere coordinated Mg(2+) that is transiently bound but strongly coupled to the RNA...
  91. ncbi Skeletal and hormonal effects of magnesium deficiency
    Robert K Rude
    USC Keck School of Medicine, Los Angeles, CA, USA
    J Am Coll Nutr 28:131-41. 2009
    b>Magnesium (Mg) is the second most abundant intracellular cation where it plays an important role in enzyme function and trans-membrane ion transport...
  92. ncbi Intake of potassium, magnesium, calcium, and fiber and risk of stroke among US men
    A Ascherio
    Department of Nutrition, Epidemiology and Health and Social Behavior, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 98:1198-204. 1998
    ..Animal experiments and epidemiological studies have suggested that high potassium intake may reduce the risk of stroke, but the evidence is inconclusive, and the role of other nutrients in potassium-rich foods remains unknown...
  93. pmc Low serum magnesium and cardiovascular mortality in chronic heart failure: a propensity-matched study
    Chris Adamopoulos
    Papageorgiou General Hospital, Thessaloniki, Greece
    Int J Cardiol 136:270-7. 2009
    Low serum magnesium levels may cause fatal ventricular arrhythmias. However, their long-term effects on mortality and morbidity in chronic heart failure patients are relatively unknown.
  94. ncbi Relationship between magnesium and clinical biomarkers on inhibition of vascular calcification
    Silvia Salem
    Charite, Medical Clinic IV, University of Berlin, Germany
    Am J Nephrol 35:31-9. 2012
    ..This study focuses on the most likely protective effects of magnesium ion (Mg(2+)) on phosphate-induced vascular calcification ex vivo/in vitro...
  95. pmc A structural equation model for assessment of links between changes in serum triglycerides, -urate, and -glucose and changes in serum calcium, -magnesium and -phosphate in type 2 diabetes and non-diabetes metabolism
    Lena Håglin
    Department of Public Health and Clinical Medicine, Family Medicine, Umea University, SE 901 87 Umea, Sweden
    Cardiovasc Diabetol 10:116. 2011
    ..between changes in serum triglycerides (S-TG), -urate (S-Urate), and -glucose (S-Glu) and changes in serum calcium (S-Ca), -magnesium (S-Mg), and -phosphate (S-P) in patients with type 2 diabetes compared with non-diabetic patients.
  96. ncbi Role of magnesium in alleviation of aluminium toxicity in plants
    Jayakumar Bose
    School of Earth and Environment, Faculty of Natural and Agricultural Sciences, University of Western Australia, Crawley WA 6009, Australia
    J Exp Bot 62:2251-64. 2011
    b>Magnesium is pivotal for activating a large number of enzymes; hence, magnesium plays an important role in numerous physiological and biochemical processes affecting plant growth and development...
  97. pmc A recurrent magnesium-binding motif provides a framework for the ribosomal peptidyl transferase center
    Chiaolong Hsiao
    School of Chemistry and Biochemistry, Parker H Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332 0400, USA
    Nucleic Acids Res 37:3134-42. 2009
    ..Here we demonstrate that the ribosomal peptidyl transferase center (PTC) is supported by a framework of magnesium microclusters (Mg(2+)-muc's)...
  98. ncbi Role of magnesium in genomic stability
    A Hartwig
    Department of Food Chemistry and Toxicology, University of Karlsruhe, Profach 6980, D 76128, Karlsruhe, Germany
    Mutat Res 475:113-21. 2001
    In cellular systems, magnesium is the second most abundant element and is involved in basically all metabolic pathways...
  99. pmc Single-molecule analysis of protein-free U2-U6 snRNAs
    Zhuojun Guo
    Department of Chemistry, Wayne State University, Detroit, Michigan, USA
    Nat Struct Mol Biol 16:1154-9. 2009
    ..The first step is strongly magnesium dependent, and we provide evidence suggesting that the second step corresponds to the formation of the ..
  100. ncbi Initial clinical experience of vasodilatory effect of intra-cisternal infusion of magnesium sulfate for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage
    Kentaro Mori
    Department of Neurosurgery, Juntendo University Shizuoka Hospital, 1129 Nagaoka, Izunokuni, Shizuoka, Japan
    Neurol Med Chir (Tokyo) 49:139-44; discussion 144-5. 2009
    The vasodilatory effect of intra-cisternal infusion of magnesium sulfate solution was evaluated in 10 patients with symptomatic vasospasm after aneurysmal subarachnoid hemorrhage (SAH) who underwent early clipping surgery...
  101. ncbi Initial evidence for the return of coronary vasoreactivity following the absorption of bioabsorbable magnesium alloy coronary stents
    Gopal Ghimire
    Royal Brompton and Harefield NHS Trust, Imperial College, London, United Kingdom
    EuroIntervention 4:481-4. 2009
    ..the endothelium independent coronary smooth muscle vasomotor function four months after implantation of magnesium alloy absorbable metal stents (AMS) as part of the Progress-AMS clinical trial (n = 5), compared with a control ..

Research Grants64

  1. Novel Therapy for Preeclampsia
    James W Larrick; Fiscal Year: 2012
    ..There is no known specific treatment, although palliative measures such as antihypertensive drugs, magnesium, and steroids, and early delivery improve outcomes...
  2. METABOLISM, MICRONUTRIENTS, AND ANTIRETROVIRAL THERAPY OUTCOMES IN ZAMBIA
    DOUGLAS CORBETT HEIMBURGER; Fiscal Year: 2010
    ..and dietary recalls 6 times in the first 3 months of ART, and measuring serum levels of phosphate, potassium, magnesium, glucose, and albumin...
  3. K-Mg-citrate as a BP lowering agent in African Americans; role of natriuresis
    ROBERT FRANKLIN REILLY; Fiscal Year: 2010
    ..Blood pressure lowering is mediated via the combined effects of the diet's three key components: potassium;magnesium;and alkali...
  4. Novel Phosphate Binder: Effects on Hyperphosphatemia, Vascular Calcification & Bo
    DEANNA J contact NELSON; Fiscal Year: 2010
    ..Preliminary studies indicate that a novel phosphate binder comprising combinations of calcium succinate and magnesium R-(+)-1-lipoate binds phosphate effectively at reasonable cost...
  5. The Magnesium and Metabolic Syndrome Trial
    Stella Lucia Volpe; Fiscal Year: 2010
    There appears to be a strong association between magnesium deficiency and insulin resistance...
  6. Establishing the Precursors of Osteoporosis in Children
    Xiping Xu; Fiscal Year: 2010
    ..hormone (PTH), osteocalcin (OC), tartrate-resistant acid phosphatase 5b (TRAP-5b);nutritional markers: magnesium, vitamin K1, and 25(OH) vitamin D;and also examine other relevant biomarkers covered by the funded MS study, ..
  7. System for Decontaminating Well Water for Drinking
    GIRISH SRINIVAS; Fiscal Year: 2010
    ..S. groundwater, both from natural and manmade sources, include significant quantities of magnesium and calcium chlorides (normal sources of hardness), heavy metals (e.g. lead), organic contaminants (e.g...
  8. Molecular and functional properties of the TRPM2 catioin channel
    Reinhold Penner; Fiscal Year: 2010
    ..family recently emerged as harboring crucial channel proteins involved in processes such as sensory perception, magnesium homeostasis or apoptosis...
  9. Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network
    Edward K Chien; Fiscal Year: 2013
    ..risk (antibiotics for preterm labor and premature rupture of the membranes, repeated antenatal corticosteroids, magnesium sulfate neuroprotection), cesarean delivery and VBAC, prevention of preeclampsia, and treatment of gestational ..
  10. Novel ex-vivo Immunoadsorption Therapy to Treat Preeclampsia
    Woo Joo; Fiscal Year: 2013
    ..Current interventions to treat PE include magnesium sulfate as an anticonvulsant and antihypertensive drugs, which can sometimes manage symptoms but do not target ..
  11. Pediatric Nephrology Seminar XXXIX
    GASTON E ZILLERUELO; Fiscal Year: 2012
    ..evolving concepts about developmental nephrology and congenital G-U anomalies, renal tubular disorders affecting magnesium, phosphate and uric acid handling, biomarkers of tubular injury, cystinosis, hypertension and new developments ..
  12. Host-pathogen signaling in group A streptococcal infection
    Michael R Wessels; Fiscal Year: 2012
    ..infection through specialized bacterial proteins that bind and respond to human antimicrobial peptides and magnesium ions...
  13. Genetic controls of mineral consumption
    Michael G Tordoff; Fiscal Year: 2013
    This is a project to discover the genetic controls that are responsible for the consumption of calcium, magnesium, potassium and sodium...
  14. Characterizing RNA-metal binding by Raman spectroscopy
    Paul R Carey; Fiscal Year: 2012
    ..b>Magnesium binding sites in the crystal structures that have been characterized by X-ray crystallography are being used to ..
  15. Aldosteron, Intracellular Leukocyte Magnesium and Inflammation in Diabetes
    Jose R Romero; Fiscal Year: 2012
    ..stimulates Na+/Mg2+ exchange activity in isolated human leukocytes leading to a decrease in intracellular magnesium and an increase in expression of pro-inflammatory factors...
  16. Structural basis of tetracycline resistance by efflux pump TetL
    DANENG WANG; Fiscal Year: 2013
    ..is mediated by membrane transporter proteins that catalyze efflux of tetracyclines in the form of tetracycline-magnesium complex. The structural basis for substrate recognition by such efflux proteins is poorly understood...
  17. MYCN-induced calcium and magnesium signaling regulates Neuroblastoma progression
    DANA LYNN TAKEKO KOOMOA; Fiscal Year: 2013
    ..In order to address this limitation, the proposed project examines the effects of calcium and magnesium signaling on cell migration and invasion in NB cells with different MYCN status...
  18. Sodium and Cardiovascular Disease in Patients with Chronic Kidney Disease
    Jiang He; Fiscal Year: 2010
    ..between dietary intake of sodium, potassium (estimated from multiple 24-hour urinary excretion), calcium, and magnesium (estimated from multiple food frequency questionnaires [FFQ]) and the risk of clinical CVD (including coronary ..
  19. Novel fluoroquinolones for killing dormant Mycobacterium tuberculosis
    Xilin Zhao; Fiscal Year: 2013
    ..Formation of these complexes, which are thought to block bacterial growth, is reversed by chelation of magnesium ion...
  20. Dietary, Hormonal, and Lifestyle Factors and Risk of Primary Hyperparathyroidism
    Julie Paik; Fiscal Year: 2010
    ..We hypothesize that lower calcium intake, higher phosphorous intake, and lower magnesium intake are independently associated with higher risk of developing primary hyperparathyroidism...
  21. Novel calcium buffer for the treatment of diastolic heart failure
    Michelle L Asp; Fiscal Year: 2013
    ..Modifying the EF-hand Ca2+ binding domain of Parv (Modified Parv) decreased Ca2+ and increased magnesium (Mg2+) affinities, improving relaxation of cardiac cells while increasing the strength of contraction...
  22. SIMULATION OF PROTON AND HYDRIDE TRANSFER IN ENZYMES
    Sharon Hammes-Schiffer; Fiscal Year: 2013
    ..proton transfer mechanism in the HDV ribozyme, focusing on the catalytic roles of a cytosine nucleotide and a magnesium ion in the active site...
  23. Continuous Glucose Monitoring with Graphene-Based Disposable Wireless Sensors
    GARY D HAVEY; Fiscal Year: 2013
    ..The feasibility of creating devices using biocompatible, dissolvable metals, such as magnesium, will also be investigated. The circuitry for wireless readout will also be developed and tested...
  24. Regulation of Magnesium Homeostasis in Bacillus subtilis
    Wade Winkler; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Magnesium ions perform many essential roles in all living organisms, including enzymatic catalysis, structural integrity, and microbial pathogenesis;however, the mechanisms that regulate homeostasis ..
  25. MRI Image Guided Radiation Therapy (IGRT) system with low cost, highly stable mag
    MICHAEL J TOMSIC; Fiscal Year: 2013
    ..aimed at converting from re-condensing liquid helium bath cooling to dry conduction cooling to cryocoolers using magnesium diboride (MgB2) superconductors...
  26. Project 1: Structure and Function of TRPM6/7 Ion Channel Domains
    Andrea Fleig; Fiscal Year: 2011
    ..Its channel activity is regulated by intracellular magnesium (Mg2*) and nucleotriphosphates (Mg-NTP)...
  27. The role of PhoP-PhoQ in an insect-bacterial symbiosis
    Colin Dale; Fiscal Year: 2013
    ..glossinidius PhoQ protein has lost the ability to respond to signals (magnesium, antimicrobial peptides and acidic pH) that play a crucial role in PhoP-PhoQ-mediated gene regulation in ..
  28. Field Administration of Stroke Therapy-Magnesium Trial (FAST-MAG)
    Jeffrey L Saver; Fiscal Year: 2013
    ..The central aim of this proposal is to demonstrate that paramedic initiation of the neuroprotective agent magnesium sulfate in the field is an efficacious and safe treatment for acute stroke...
  29. BIOCHEMICAL AND BIOPHYSICAL NATURE OF CLAUDIN-16 AND CLAUDIN-19 CHANNELS
    Jianghui Hou; Fiscal Year: 2013
    ..Claudin-16 KD animals show chronic renal wasting of magnesium and calcium, developing renal nephrocalcinosis comparable to that seen in human patients with FHHNC...
  30. Antimicrobial Biodegradable Bone Graft for Craniofacial/Maxillofacial Application
    Arash Aslani; Fiscal Year: 2013
    ..The beads would be made of biodegradable magnesium. The beads will be coated with hydroxyapatite (HA) incorporated with gentamycin...
  31. Scope and Causes of Stillbirth
    George Saade; Fiscal Year: 2009
    ..the Risk of Congenital Heart Disease;Twin-Twin Transfusion Syndrome Trial;and Beneficial Effects of Antenatal Magnesium Sulfate Study (BEAM)...
  32. Hopkins Center for Eliminate Cardiovascular Health Disparities
    Lisa A Cooper; Fiscal Year: 2013
    ..controlled trial of culturally-tailored nutritional advice and a mineral supplement containing potassium, magnesium, and Vitamin C...
  33. SUBSTANCE P-MEDIATED CARDIOVASCULAR INFLAMMATION
    William Weglicki; Fiscal Year: 2009
    Abstract: Neurogenic inflammation results from magnesium deficiency (MgD), and is mediated by Substance P (SP)...
  34. Trace element levels and risk of stroke
    Leslie Ain McClure; Fiscal Year: 2013
    ..The proposed study will focus on arsenic, cadmium, mercury, magnesium and selenium...
  35. Functional Analysis of the Bifunctional Ion Channel and Kinase TRPM7
    Loren W Runnels; Fiscal Year: 2013
    ..Surprisingly, our research revealed that incubation of the embryos with excess magnesium or expression of a magnesium transporter reverses this phenotype, giving the first evidence that magnesium plays ..
  36. Mechanistic bases of subtype-specific NMDA receptor channel properties
    BETH SIEGLER RETCHLESS; Fiscal Year: 2010
    ..NMDAR) is a glutamate-gated ion channel that is highly permeable to calcium (Ca++), but can be blocked by magnesium (Mg++). Most NMDA receptors are tetramers of two NR1 and two NR2 subunits...
  37. Traumatic Brain Injury Clinical Trials Network
    Nancy R Temkin; Fiscal Year: 2011
    ..Using a randomized. double-blind design, the concept protocol evaluates magnesium sulfate as a neuroprotectant and anti-epileptogenic agent following head injury...
  38. Zymogen activation in pancreatitis
    Fred S Gorelick; Fiscal Year: 2013
    ..LR is usually less acidic (pH ~6.5), but contains high concentrations of calcium, magnesium, and lactate...
  39. Regulation of Bacterial Two-Component Signaling by Small Membrane Proteins
    MARK D GOULIAN; Fiscal Year: 2013
    ..effect of these proteins on the dynamics and input-output behavior of PhoQ/PhoP signaling for stimulation with magnesium, antimicrobial peptides and pH, compare the behavior of the low pH response among natural E...
  40. Intravenous Magnesium for Sickle Cell Vasoocclusive Crisis
    David C Brousseau; Fiscal Year: 2013
    ..We have recently tested an alternative approach, intravenous magnesium, that produces vaso- dilation through both endothelium-dependent nitric oxide mechanisms, as well as direct ..
  41. Personalized Prevention of Colorectal Cancer
    Chang Yu; Fiscal Year: 2013
    ..High calcium intake and magnesium may protect against colorectal cancer and adenoma, however, results have been inconsistent...
  42. Magnesium Channel Cation Selectivity
    Michael E Maguire; Fiscal Year: 2013
    ..Their crystallization may provide additional conformational information for CorA. Aim 2 will explore analogous issues for MgtE using the same approaches. ..
  43. Phase 2 Study of Magnesium Supplements in the Treatment of PXE
    Mark Lebwohl; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The goal of this project is to assess the efficacy of magnesium oxide on the reversal of elastic fiber calcification and clinical lesions of PXE...
  44. Structural and temporal analyses of the folding landscape of the B12 riboswitch
    JAMES EDWARD JOHNSON; Fiscal Year: 2012
    ..the aptamer domain will be investigated using chemical probing techniques that will highlight the importance of magnesium and adenosylcobalamin (AdoCbl) to promote a stable structure...
  45. MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMA
    Nancy Temkin; Fiscal Year: 2004
    ..of moderate or severe head injury the ongoing trial tests whether these consequence can be ameliorated by magnesium sulfate...
  46. Trafficking and Regulation of the NMDA Receptor Subunit NR2C
    Bo Shiun Chen; Fiscal Year: 2012
    ..unique properties on NMDA receptors producing channels relatively insensitive to the voltage-dependent block by magnesium ions. NR2C is highly enriched in cerebellum, thalamus and olfactory bulb...
  47. Accelerate improvements in MgB2 superconductor wire for new cryogen-free low cost
    MICHAEL J TOMSIC; Fiscal Year: 2010
    ..The development of magnesium diboride (MgB2) superconductors has been fostered by two NIH SBIR Phase 1 &II grants over the last 4 years...
  48. Anti-Cancer RNA Nanoconjugates
    Adam Wanekaya; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Here we will synthesize novel next generation nanoparticles of manganese or magnesium oxide or doped or composites of these with cobalt and zinc...
  49. Dietary Factors Affecting Calcium and Zinc Absorption
    Steven Abrams; Fiscal Year: 2006
    ..We use stable isotope methods that are safe and applicable globally to assess mineral metabolism (calcium, zinc, magnesium, iron, copper)...
  50. Quality of Life After Treatment with Magnesium for Acute Sickle Cell Pain Episode
    Julie A Panepinto; Fiscal Year: 2013
    ..of children presenting with an acute sickle cell pain episode who are randomized to receive treatment with magnesium (Mg) or placebo, the parent trial to this proposed project...
  51. Prevention of neointimal thickening by Mst1
    Junichi Sadoshima; Fiscal Year: 2006
    ..delivery of Mst1 from stents, we will utilize completely biodegradable stents made of noncombustible magnesium and a proprietary technique to coat the stents with mammalian expression plasmids, which can be efficiently ..
  52. Structural Basis for Bridged Bimetallic Enzyme Catalysis
    Dagmar Ringe; Fiscal Year: 2009
    ..A large percentage of those contain two metal ions (usually first-row transition metals or magnesium) connected by a bridging ligand (usually a carboxylate group)...
  53. POLYUNSATURATES AND KC1 TO CONTROL MILD HYPERTENSION
    Frank Sacks; Fiscal Year: 1991
    ..proposed to assess the hypotensive potential of dietary polyunsaturated fatty acids in fish, oil, and of dietary magnesium, alone and with supplemental potassium. 1...
  54. High Performance Single Crystal Ultrasound Device for Medical Imaging
    Jian Tian; Fiscal Year: 2009
    ..Piezoelectric single crystals such as lead magnesium niobate - lead titanate (PMN-PT) have superior dielectric and piezoelectric properties suitable for medical ..
  55. Computer Modeling of Oligonucleotide Reaction Rates
    WILLIAM J KENNELLY; Fiscal Year: 2010
    ..1 to 1.01 M and magnesium ion concentrations in the range of 0 to 6 mM...
  56. Plasma synthesized doped boron nanopowder for magnesium diboride superconductors
    JAMES V MARZIK; Fiscal Year: 2012
    ..As a result, MRI producers are pushing to develop MRI systems based on LHe-free magnesium diboride (MgB2) superconducting magnets...
  57. LuAG:Ce,Zr Scintillators for PET
    KEITH ROZENBURG; Fiscal Year: 2007
    ..of transparent yttrium aluminum garnet (YAG) for lasers and TA&T's own developments of transparent magnesium aluminate among other transparent ceramics we will address cost and resolution in PET imaging through the ..
  58. ADVERSE EVENTS WITH MAGNESIUM SULFATE
    George Macones; Fiscal Year: 2000
    ..b>Magnesium sulfate (MgSO4) is among the most commonly used drugs for this indication...
  59. MECHANISM FOR CHARGED-RELATED NEPHROTOXICITY
    Darryl Peterson; Fiscal Year: 1993
    ..Preliminary evidence supports this interpretation. Calcium and magnesium have been reported to protect against gentamicin nephrotoxicity, and both inhibit binding of gentamicin to the ..
  60. Psychophysics of Divalent Salts and Metallic Taste
    HARRY LAWLESS; Fiscal Year: 2006
    ..of the period table including calcium, an active participant in various steps of taste transduction, as well as magnesium and barium...
  61. Magnesium's Antihypertensive Effects in Preeclampsia
    CYNTHIA STANDLEY; Fiscal Year: 2003
    ..b>Magnesium sulfate is the standard treatment for preeclampsia...
  62. INDOMETHACIN FOR ADJUVANT TOCOLYSIS
    George Macones; Fiscal Year: 2004
    ..b>Magnesium sulfate is currently the most commonly prescribed agent for tocolysis in the United States...
  63. ROLE OF PROTEIN PHOSPHATASES IN INSULIN SECRETION
    Anjaneyulu Kowluru; Fiscal Year: 2004
    ..Physiologic concentrations of glutamate and magnesium stimulate the carboxyl methylation as well as the catalytic activity of this PPase and concomitantly increase ..
  64. Implantable Biodegradable RF-Powered Tissue Stimulator and Electrodes
    Lee E Weiss; Fiscal Year: 2012
    ..Our novel approach will be to use RF coil circuits based on biocompatible and bioresorbable magnesium alloy conductive and resistive components, and also use this same alloy as the material for the electrodes...