rubidium

Summary

Summary: An element that is an alkali metal. It has an atomic symbol Rb, atomic number 37, and atomic weight 85.47. It is used as a chemical reagent and in the manufacture of photoelectric cells.

Top Publications

  1. ncbi Energetic optimization of ion conduction rate by the K+ selectivity filter
    J H Morais-Cabral
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520, USA
    Nature 414:37-42. 2001
  2. ncbi The structure of the potassium channel: molecular basis of K+ conduction and selectivity
    D A Doyle
    Laboratory of Molecular Neurobiology and Biophysics and the Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 280:69-77. 1998
  3. ncbi Ion permeation mechanism of the potassium channel
    J Aqvist
    Department of Cell and Molecular Biology, Uppsala University, Biomedical Center, Sweden
    Nature 404:881-4. 2000
  4. pmc Hydrogen peroxide mediates plant root cell response to nutrient deprivation
    Ryoung Shin
    Donald Danforth Plant Science Center, St Louis, MO 63132, USA
    Proc Natl Acad Sci U S A 101:8827-32. 2004
  5. pmc AtKUP1: an Arabidopsis gene encoding high-affinity potassium transport activity
    E J Kim
    Department of Biology, University of California, San Diego, La Jolla 92093, USA
    Plant Cell 10:51-62. 1998
  6. ncbi Characterization of a hERG screen using the IonWorks HT: comparison to a hERG rubidium efflux screen
    Steve Sorota
    Department of Neurobiology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA steve sorota spcorp com
    Assay Drug Dev Technol 3:47-57. 2005
  7. ncbi Measurement of rubidium and xenon absolute polarization at high temperatures as a means of improved production of hyperpolarized (129)Xe
    N J Shah
    Institute of Medicine, Research Centre Julich, 52428 Jülich
    NMR Biomed 13:214-9. 2000
  8. pmc The potassium transporter AtHAK5 functions in K(+) deprivation-induced high-affinity K(+) uptake and AKT1 K(+) channel contribution to K(+) uptake kinetics in Arabidopsis roots
    Markus Gierth
    Division of Biological Sciences, Cell and Developmental Biology Section and Center for Molecular Genetics, University of California San Diego, La Jolla, California 92093 0116, USA
    Plant Physiol 137:1105-14. 2005
  9. pmc Tight coupling of rubidium conductance and inactivation in human KCNQ1 potassium channels
    Guiscard Seebohm
    Department of Physiology, University of Utah, Salt Lake City, UT USA, Physiologisches Institut I, Tubingen, Germany
    J Physiol 552:369-78. 2003
  10. ncbi Adenosine diphosphate as an intracellular regulator of insulin secretion
    C G Nichols
    Department of Cell Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Science 272:1785-7. 1996

Research Grants

  1. Functional Brain Networks: A Novel Approach to Address Clinical Challenges in PD
    David Eidelberg; Fiscal Year: 2010
  2. PATHOGENESIS OF HERPETIC KERATITIS
    WILLIAM O BRIEN; Fiscal Year: 2002
  3. PATHOGENESIS OF HERPETIC KERATITIS
    WILLIAM O BRIEN; Fiscal Year: 2000
  4. PATHOGENESIS OF HERPETIC KERATITIS
    WILLIAM O BRIEN; Fiscal Year: 2001
  5. BIOCHEMICAL INTERACTIONS OF INSULIN WITH THE LENS
    John Coulter; Fiscal Year: 1980
  6. MYOCARDIAL VIABILITY BY PET & PTCA/CAB TO IMPROVE LV EF
    K Gould; Fiscal Year: 1993
  7. TRACE ELEMENT NUTRITION OF THE LENS--ZINC
    J Bentley; Fiscal Year: 1990
  8. Chronic Nicotine Effects on Receptor Subtypes
    David C Perry; Fiscal Year: 2010
  9. Chronic Nicotine Effects on Receptor Subtypes
    David Perry; Fiscal Year: 2009
  10. INORGANIC ION EXCHANGER FOR USE IN 82SR/82RB SEPARATIONS
    Paul Sylvester; Fiscal Year: 2000

Detail Information

Publications206 found, 100 shown here

  1. ncbi Energetic optimization of ion conduction rate by the K+ selectivity filter
    J H Morais-Cabral
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520, USA
    Nature 414:37-42. 2001
    ..The energetic balance between these configurations is a clear example of evolutionary optimization of protein function...
  2. ncbi The structure of the potassium channel: molecular basis of K+ conduction and selectivity
    D A Doyle
    Laboratory of Molecular Neurobiology and Biophysics and the Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 280:69-77. 1998
    ..The architecture of the pore establishes the physical principles underlying selective K+ conduction...
  3. ncbi Ion permeation mechanism of the potassium channel
    J Aqvist
    Department of Cell and Molecular Biology, Uppsala University, Biomedical Center, Sweden
    Nature 404:881-4. 2000
    ..Other putative permeation pathways can be excluded because they would involve states that are too high in energy...
  4. pmc Hydrogen peroxide mediates plant root cell response to nutrient deprivation
    Ryoung Shin
    Donald Danforth Plant Science Center, St Louis, MO 63132, USA
    Proc Natl Acad Sci U S A 101:8827-32. 2004
    ..ROS production is an early root response to K(+) deficiency that modulates gene expression and physiological changes in the kinetics of K(+) uptake...
  5. pmc AtKUP1: an Arabidopsis gene encoding high-affinity potassium transport activity
    E J Kim
    Department of Biology, University of California, San Diego, La Jolla 92093, USA
    Plant Cell 10:51-62. 1998
    ..It is proposed that plants contain multiple potassium transporters for high-affinity uptake and that the AtKUP family may provide important components of high- and low-affinity K+ nutrition and uptake into various plant cell types...
  6. ncbi Characterization of a hERG screen using the IonWorks HT: comparison to a hERG rubidium efflux screen
    Steve Sorota
    Department of Neurobiology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA steve sorota spcorp com
    Assay Drug Dev Technol 3:47-57. 2005
    ..human ethera- go-go-related gene (hERG) patch clamp data and an alternative functional screen based on rubidium flux...
  7. ncbi Measurement of rubidium and xenon absolute polarization at high temperatures as a means of improved production of hyperpolarized (129)Xe
    N J Shah
    Institute of Medicine, Research Centre Julich, 52428 Jülich
    NMR Biomed 13:214-9. 2000
    We report on a rubidium-xenon (Rb-Xe) polarization unit for the continuous production of large quantities of hyperpolarized (129)Xe...
  8. pmc The potassium transporter AtHAK5 functions in K(+) deprivation-induced high-affinity K(+) uptake and AKT1 K(+) channel contribution to K(+) uptake kinetics in Arabidopsis roots
    Markus Gierth
    Division of Biological Sciences, Cell and Developmental Biology Section and Center for Molecular Genetics, University of California San Diego, La Jolla, California 92093 0116, USA
    Plant Physiol 137:1105-14. 2005
    ..The results demonstrate an in vivo function for AtHAK5 in the inducible high-affinity K(+) uptake system in Arabidopsis roots...
  9. pmc Tight coupling of rubidium conductance and inactivation in human KCNQ1 potassium channels
    Guiscard Seebohm
    Department of Physiology, University of Utah, Salt Lake City, UT USA, Physiologisches Institut I, Tubingen, Germany
    J Physiol 552:369-78. 2003
    ....
  10. ncbi Adenosine diphosphate as an intracellular regulator of insulin secretion
    C G Nichols
    Department of Cell Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Science 272:1785-7. 1996
    ..Thus, by binding to SUR NBF2 and antagonizing ATP inhibition of KATP++ channels, intracellular MgADP may regulate insulin secretion...
  11. ncbi Rubidium marking of Anopheles mosquitoes detectable by field-capable X-ray spectrometry
    E E Wilkins
    Centers for Disease Control and Prevention CDC, Atlanta, Georgia, USA
    Med Vet Entomol 21:196-203. 2007
    ..stricto (Diptera: Culicidae) and Anopheles stephensi Liston larvae were cultured to pupation in water containing rubidium (Rb) Cl at concentrations up to 1000 p.p.m. Rb...
  12. doi In situ Raman probing of graphene over a broad doping range upon rubidium vapor exposure
    Romain Parret
    Laboratoire Charles Coulomb UMR 5221, Universite Montpellier 2, F 34095 Montpellier, France
    ACS Nano 7:165-73. 2013
    ..Raman scattering experiments on single-layer graphene (SLG) and Bernal bilayer graphene (BLG) during exposure to rubidium vapor. The G- and 2D-band evolutions with doping time are presented and analyzed...
  13. ncbi Functional analysis of native and recombinant ion channels using a high-capacity nonradioactive rubidium efflux assay
    G C Terstappen
    Bayer AG, Pharma Research Centre, Wuppertal, D 42096, Germany
    Anal Biochem 272:149-55. 1999
    A nonradioactive cell-based rubidium (Rb(+)) efflux assay for functional analysis of native and recombinant ion channels has been developed...
  14. ncbi Gamma-hydroxybutyrate receptor function determined by stimulation of rubidium and calcium movements from NCB-20 neurons
    V Kemmel
    Institut de Chimie Biologique and INSERM U 338, Faculte de Medecine, 11 rue Humann, 67085, Strasbourg Cedex, France
    Neuroscience 116:1021-31. 2003
    ..This process must at least partially trigger small conductance calcium activated channel activation leading to gamma-hydroxybutyrate-induced hyperpolarization...
  15. ncbi Structure of the hydrated and dimethyl sulfoxide solvated rubidium ions in solution
    Paola D'Angelo
    Dipartimento di Chimica, Universita di Roma La Sapienza, Piazzale Aldo Moro 5, I 00185 Rome, Italy
    Inorg Chem 43:3543-9. 2004
    The structure of the hydrated and the dimethyl sulfoxide solvated rubidium ions in solution has been determined by means of large-angle X-ray scattering (LAXS) and extended X-ray absorption fine structure (EXAFS) studies...
  16. pmc External TEA block of shaker K+ channels is coupled to the movement of K+ ions within the selectivity filter
    Jill Thompson
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Gen Physiol 122:239-46. 2003
    ....
  17. pmc E2P state stabilization by the N-terminal tail of the H,K-ATPase beta-subunit is critical for efficient proton pumping under in vivo conditions
    Katharina L Dürr
    Institute of Chemistry, Technical University of Berlin, D 10623 Berlin, Germany
    J Biol Chem 284:20147-54. 2009
    ....
  18. ncbi Atomic structure of a Na+- and K+-conducting channel
    Ning Shi
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9040, USA
    Nature 440:570-4. 2006
    ..We conclude that the sequence of the NaK selectivity filter resembles that of a cyclic nucleotide-gated channel and its structure may represent that of a cyclic nucleotide-gated channel pore...
  19. pmc Activation of ferret erythrocyte Na+-K+-2Cl- cotransport by deoxygenation
    Peter W Flatman
    Membrane Biology Group, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh EH8 9XD, Scotland, UK
    J Physiol 563:421-31. 2005
    ..They also indicate that more than one kinase and phosphatase are involved in cotransporter phosphorylation...
  20. doi Ru(bpy)3(2+)-doped silica nanoparticles labeling for a sandwich-type electrochemiluminescence immunosensor
    Xia Yang
    Key Laboratory on Luminescence and Real time Analysis, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China
    Biosens Bioelectron 25:1851-5. 2010
    ..This new strategy for preparation of the ECL immunosensor could be easily realized and has potential application in ultrasensitive bioassays...
  21. pmc Regulation of Na+-K+-2Cl- cotransport by protein phosphorylation in ferret erythrocytes
    P W Flatman
    Membrane Biology Group, Department of Biomedical Sciences, University Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    J Physiol 517:699-708. 1999
    ..Phosphorylation of the phosphatase is probably regulated by members of the Src family of tyrosine kinases...
  22. ncbi The Candida albicans Na(+)/H(+) antiporter exports potassium and rubidium
    O Kinclová
    Department of Membrane Transport, Institute of Physiology, Prague, Czech Republic
    FEBS Lett 504:11-5. 2001
    ..A.36) but it transports besides toxic sodium and lithium also rubidium and potassium...
  23. ncbi The occupancy of ions in the K+ selectivity filter: charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates
    Yufeng Zhou
    Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute and Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Mol Biol 333:965-75. 2003
    ..We conclude that electrostatic balance and coupling of ion binding to a protein conformational change underlie high conduction rates in the setting of high selectivity...
  24. ncbi A new family of K+ transporters from Arabidopsis that are conserved across phyla
    F J Quintero
    Laboratory of Plant Physiology and Biophysics, University of London, Wye College, UK
    FEBS Lett 415:206-11. 1997
    ..These and additional results suggest that AtKT1 and AtKT2 belong to a superfamily of cation transporters that have been conserved through evolution...
  25. ncbi Structural rearrangements underlying K+-channel activation gating
    E Perozo
    Department of Molecular Physiology and Biological Physics and Center for Structural Biology, University of Virginia Health Sciences Center, Charlottesville, VA 22906 0011, USA
    Science 285:73-8. 1999
    ..Although the extracellular residues flanking the selectivity filter remained immobile during gating, small movements were detected at the C-terminal end of the pore helix, with possible implications to the gating mechanism...
  26. pmc Functional identification of ion binding sites at the internal end of the pore in Shaker K+ channels
    Jill Thompson
    Department of Pharmacology and Physiology, University of Rochester Medical Center, NY 14642, USA
    J Physiol 549:107-20. 2003
    ..These results provide information on the fine-structure of ion interactions with the inner end of the pore in K+ channels...
  27. ncbi PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1)
    Brian F X Dowd
    Yale University, School of Medicine, Department of Cellular and Molecular Physiology, New Haven, Connecticut 06520 0826, USA
    J Biol Chem 278:27347-53. 2003
    ..In cells preloaded with 32Pi, the phosphorylation of PASK, but not DNPASK, coincides with that of NKCC1 and increases 5.5 +/- 0.36-fold in low [Cl]e. These data conclusively link PASK with the phosphorylation and activation of NKCC1...
  28. pmc Expression of KT/KUP genes in Arabidopsis and the role of root hairs in K+ uptake
    Sung Ju Ahn
    Donald Danforth Plant Science Center, 975 North Warson Road, St Louis, Missouri 63132, USA
    Plant Physiol 134:1135-45. 2004
    ..This suggests an important role for root hairs in K(+) uptake. The growth and rubidium (Rb(+)) uptake of two root hair mutants, trh1-1 (tiny root hairs) and rhd6 (root hair defective), were studied to ..
  29. ncbi A mutant KcsA K(+) channel with altered conduction properties and selectivity filter ion distribution
    Ming Zhou
    Howard Hughes Medical Institute and Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, NY 10021, USA
    J Mol Biol 338:839-46. 2004
    ..The mutation does not affect the conduction of Rb(+). These results can be understood in the context of a conduction mechanism in which a pair of K ions switch between energetically balanced 1,3 and 2,4 configurations...
  30. ncbi Ion binding affinity in the cavity of the KcsA potassium channel
    Yufeng Zhou
    Howard Hughes Medical Institute and Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Biochemistry 43:4978-82. 2004
    ..These results are consistent with a fairly large (more negative than -100 mV) electrostatic potential inside the cavity, and they also imply the presence of a weak nonelectrostatic component to a cation's interaction with the cavity...
  31. pmc Tail end of the s6 segment: role in permeation in shaker potassium channels
    Shinghua Ding
    Department of Physiology, Jefferson Medical College, Philadelphia, PA 19107, USA
    J Gen Physiol 120:87-97. 2002
    ..These results indicate that S6(T) residues have an influence on the conformation of the open activation gate, reflected in both the stability of the open state and the energy barriers it presents to ions...
  32. pmc Gating and flickery block differentially affected by rubidium in homomeric KCNQ1 and heteromeric KCNQ1/KCNE1 potassium channels
    M Pusch
    Istituto di Cibernetica e Biofisica, Consiglio Nazionale della Ricerche, Via De Marini 6, I 16149 Genova, Italy
    Biophys J 78:211-26. 2000
    ..using the two-electrode voltage-clamp and the patch-clamp technique and high extracellular potassium (K) and rubidium (Rb) solutions...
  33. ncbi The effects of elevated glucose on Na+/K(+)-ATPase of cultured bovine retinal pigment epithelial cells measured by a new nonradioactive rubidium uptake assay
    J Y Crider
    Molecular Pharmacology Unit, Alcon Laboratories, Inc, Fort Worth, Texas, USA
    J Ocul Pharmacol Ther 13:337-52. 1997
    ..The results of the present study suggest that hyperglycemia-induced loss of Na+/K(+)-ATPase function in RPE cells, which responds to aldose reductase inhibitor treatment, contributes to the pathogenesis of diabetic retinopathy...
  34. doi Relative contribution of AtHAK5 and AtAKT1 to K+ uptake in the high-affinity range of concentrations
    Francisco Rubio
    Departamento de Nutrición Vegetal, Centro de Edafología y Biología Aplicada del Segura CSIC, Apartado de Correos 164, Murcia 30100, Spain
    Physiol Plant 134:598-608. 2008
    ....
  35. ncbi Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family
    C M Gillen
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 271:16237-44. 1996
    ..These data demonstrate that the KCC1 cDNAs encode a widely expressed K-Cl cotransporter with the characteristics of the K-Cl transporter that has been characterized in red cells...
  36. pmc A mutation in the Arabidopsis KT2/KUP2 potassium transporter gene affects shoot cell expansion
    Rangasamy P Elumalai
    Department of Biology, University of North Carolina at Chapel Hill, Coker Hall, Chapel Hill, NC 27599 3280, USA
    Plant Cell 14:119-31. 2002
    ..coli mutant. A P(SHY3)::GUS fusion is expressed in growing portions of the plant. These results suggest that KT2/KUP2/SHY3 mediates K(+)-dependent cell expansion in growing tissues...
  37. ncbi Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor
    N Inagaki
    Division of Molecular Medicine, Chiba University School of Medicine, Japan
    Science 270:1166-70. 1995
    ..Gene mapping data show that these two potassium channel subunit genes are clustered on human chromosome 11 at position 11p15.1...
  38. ncbi Alteration of ionic selectivity of a K+ channel by mutation of the H5 region
    A J Yool
    Department of Molecular and Cellular Physiology, Stanford University Medical Center, California 94305 5426
    Nature 349:700-4. 1991
    ..The mutations that substantially altered selectivity had little effect on the gating properties of the channel. We conclude that the H5 region is likely to line the pore of the K+ channel...
  39. ncbi Cloning and functional characterization of the high-affinity K+ transporter HAK1 of pepper
    M Angeles Martínez-Cordero
    Departamento de Nutrición Vegetal, Centro de Edafología y Biología Aplicada del, Segura CSIC, Apartado de Correos 164, Murcia, 30100, Spain
    Plant Mol Biol 56:413-21. 2004
    ..3 and 1.9 microM, respectively. Rb+ uptake was competitively inhibited by micromolar concentrations of NH and Cs+, and by millimolar concentrations of Na+...
  40. pmc The ionic environment controls the contribution of the barley HvHAK1 transporter to potassium acquisition
    Fabiana R Fulgenzi
    Instituto de Investigaciones Biotecnologicas, Universidad Nacional de San Martín Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Tecnología Industrial, San Martin 1650, Provincia de Buenos Aires, Argentina
    Plant Physiol 147:252-62. 2008
    ..It is shown that the yeast protein phosphatase PPZ1 as well as the halotolerance HAL4/HAL5 kinases negatively regulate the HvHAK1-mediated K+ transport...
  41. pmc The multi-ion nature of the pore in Shaker K+ channels
    P Perez-Cornejo
    University of Rochester Medical School, Department of Physiology, New York 14642
    Biophys J 66:1929-38. 1994
    ..91; this increased to 1.3 at 40 mM Cs+. We show that a 4-barrier, 3-site permeation model can simulate these and many of the other known properties of ion permeation in Shaker channels...
  42. ncbi Efficiency of rubidium marking in Aedes albopictus (Diptera: Culicidae): preliminary evaluation on persistence of egg labeling, survival, and fecundity of marked female
    Rafael Maciel-de-Freitas
    Laboratório de Transmissores de Hematozoários, Instituto Oswaldo Cruz FIOCRUZ, Av Brasil 4365, 21040 900 Rio de Janeiro, RJ, Brazil
    Mem Inst Oswaldo Cruz 99:823-7. 2004
    b>Rubidium chloride (RbCl) has been used for the study of vector biology and behavior, although the efficacy of marking, egg production, and survivorship of marked females have been poorly studied...
  43. pmc A thermodynamic study of electroneutral K-Cl cotransport in pH- and volume-clamped low K sheep erythrocytes with normal and low internal magnesium
    P K Lauf
    Department of Physiology and Biophysics, Wright State University School of Medicine, Dayton, Ohio 45401 0927, USA
    J Gen Physiol 108:341-50. 1996
    ..Thus, basal as well as low internal Mg-stimulated net K-Cl cotransport depends on the electrochemical potential gradient of KCl...
  44. ncbi Protons as substitutes for sodium and potassium in the sodium pump reaction
    C Polvani
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Biol Chem 263:16757-63. 1988
    ..8. These ATP-dependent cardiac glycoside-sensitive proton movements indicate Na,K-ATPase mediated Na+/H+ exchange in the absence of extracellular K+ as well as H+/K+ exchange in the absence of cytoplasmic Na+...
  45. ncbi [Potassium transport in erythrocytes from patients with gentamicin intolerance]
    F V Toropova
    Institute of Cytology RAS, St Petersburg
    Tsitologiia 44:1194-8. 2002
    A study was made of rubidium (potassium analog) influxes via ouabain-sensitive Na/K pump, bumetanide-sensitive cotransport and resistant to ouabain bumetanide membrane ion pathways and of the intracellular potassium and sodium contents in ..
  46. ncbi Metallic content of wines from the Canary Islands (Spain). Application of artificial neural networks to the data analysis
    Sergio Frías
    Department of Analytical Chemistry, Nutrition and Food Science, University of La Laguna, Santa Cruz de Tenerife, Spain
    Nahrung 46:370-5. 2002
    ..Thus, Lanzarote presented the highest mean content in sodium and lithium and the lowest mean content in rubidium, and La Palma presented the highest mean content in strontium and rubidium...
  47. ncbi Low-affinity potassium uptake by Saccharomyces cerevisiae is mediated by NSC1, a calcium-blocked non-specific cation channel
    Hermann Bihler
    Botanisches Institut, Lehrstuhl I, Universitat Karlsruhe, Germany
    Biochim Biophys Acta 1558:109-18. 2002
    ..Growth inhibition by lithium ions is probably a toxic effect, whereas growth inhibition by ammonium ions probably results from competitive inhibition, i.e. displacement of intracellular potassium by entering ammonium...
  48. ncbi Cl secretagogues reduce basolateral K permeability in the rabbit corneal epithelium
    O A Candia
    Department of Ophthalmology, Mount Sinai School of Medicine, 100th Street and 5th Avenue New York, NY 10029 6574, USA
    J Membr Biol 190:197-205. 2002
    ....
  49. ncbi Characterization of potassium transport in wild-type and isogenic yeast strains carrying all combinations of trk1, trk2 and tok1 null mutations
    Adam Bertl
    Universitat Karlsruhe, Germany
    Mol Microbiol 47:767-80. 2003
    ..Based on this finding, we have established a growth-based assay that monitors the in vivo activity of Tok1p...
  50. pmc The link between ion permeation and inactivation gating of Kv4 potassium channels
    Mohammad Shahidullah
    Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Biophys J 84:928-41. 2003
    ..By examining possible changes in ionic selectivity and the influence of elevating the external K(+) concentration, additional experiments did not support the presence of C-type inactivation in Kv4 channels...
  51. ncbi Effect of acute hyperglycemia on erythrocyte membrane ion transport in offspring of hypertensive parents
    Gabriela Suchankova
    Diabetes Center, Institute for Clinical and Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic
    J Hypertens 21:1325-30. 2003
    ..The aims of this study were to assess RBC ion transport activities under basal conditions and to test the in vivo effect of acute hyperglycemia on RBC ion transport in the offspring of hypertensive parents (OHP) and healthy controls (C)...
  52. ncbi Intracellular Na concentration and Rb uptake in proximal convoluted tubule cells and abundance of Na/K-ATPase alpha1-subunit in NHE3-/- mice
    Franz X Beck
    Physiologisches Institut der Universitat, Pettenkoferstrasse 12, 80336, Munich, Germany
    Pflugers Arch 446:100-5. 2003
    ..There were no significant changes of cell Na concentration and Rb uptake in distal convoluted tubule, connecting tubule, principal and intercalated cells...
  53. ncbi Effects of palytoxin on cation occlusion and phosphorylation of the (Na+,K+)-ATPase
    M T Tosteson
    Laboratory for Membrane Transport, Department of Cell Biology, Harvard Medical School, One Kendall Square, Building 600 Third Floor, Cambridge, MA 02139, USA
    J Membr Biol 192:181-9. 2003
    ....
  54. ncbi K(+) transport in Malpighian tubules of Tenebrio molitor L: a study of electrochemical gradients and basal K(+) uptake mechanisms
    U I M Wiehart
    Department of Zoology and Entomology, University of Pretoria, Pretoria 0002, South Africa
    J Exp Biol 206:949-57. 2003
    ..b>Rubidium, a 'permeant' potassium substitute, caused a hyperpolarization of V(bl), indicating the specificity of K(+) ..
  55. pmc Potassium channel, ions, and water: simulation studies based on the high resolution X-ray structure of KcsA
    Carmen Domene
    Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    Biophys J 85:2787-800. 2003
    ..A preliminary comparison of the use of particle mesh Ewald versus cutoff protocols for the treatment of long-range electrostatics suggests some difference in the kinetics of ion translocation within the filter...
  56. ncbi The yeast potassium transporter TRK2 is able to substitute for TRK1 in its biological function under low K and low pH conditions
    Bertha Michel
    Depto de Genética Molecular, Instituto de Fisiologia Celular, UNAM, Circuito exterior s n, Ciudad Universitaria, D F 04510, Mexico
    Yeast 23:581-9. 2006
    ..Taken together, these results indicate that TRK2 encodes a functional K+ transporter that, under our experimental conditions, displays distinctive kinetic characteristics...
  57. pmc A trapped intracellular cation modulates K+ channel recovery from slow inactivation
    Evan C Ray
    Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Gen Physiol 128:203-17. 2006
    ..We propose that the rate of recovery from slow inactivation is determined by the ability of entrapped cations to move into a binding site in the channel's selectivity filter, and refilling of this site is required for recovery...
  58. ncbi Analysis of the monovalent ion fluxes in U937 cells under the balanced ion distribution: recognition of ion transporters responsible for changes in cell ion and water balance during apoptosis
    A A Vereninov
    Institute of Cytology RAS, Tikhoretsky Avenue 4, 194064 St Petersburg, Russia
    Cell Biol Int 31:382-93. 2007
    ....
  59. ncbi Cation transport activity of anion exchanger 1 mutations found in inherited distal renal tubular acidosis
    Stephen Walsh
    Laboratoire de Physiologie des Membranes Cellulaires, UMR6548, Centre National de la Recherche Scientifique Université de Nice, Bâtiment de Sciences Naturelles, Nice, France
    Am J Physiol Renal Physiol 295:F343-50. 2008
    ..These findings have potential structural and functional implications for AE1, and they indicate that while anion exchange and cation conductance properties are distinct, they can coexist...
  60. ncbi Rubidium chloride tolerant callus cultures of rice (Oryza sativa L.) accumulate more potassium and cross tolerate to other salts
    R Naga Amrutha
    Department of Genetics, Osmania University, Hyderabad 500 007, India
    Plant Cell Rep 26:1647-62. 2007
    ..were established in Murashige and Skoog's (MS) medium containing lethal concentrations (50 mM) of rubidium chloride (RbCl) as a selective agent...
  61. ncbi Characterization of glial cell K-Cl cotransport
    Kenneth B E Gagnon
    Cell Biophysics Group, Wright State University, Dayton, OH 4543, USA
    Cell Physiol Biochem 20:121-30. 2007
    ..The molecular mechanism of K-Cl cotransport (KCC) consists of at least 4 isoforms, KCC 1, 2, 3, and 4 which, in multiple combinations, exist in most cells, including erythrocytes and neuronal cells...
  62. doi High temperature NMR study of the local structure of molten LaF3-AF (A = Li, Na, K and Rb) mixtures
    Anne Laure Rollet
    Centre de Recherche sur les Matériaux à Haute Température CNRS, Orleans cedex 2, France
    Phys Chem Chem Phys 10:3222-8. 2008
    ..The coordination number of lanthanum is decreased versus AF amount all the more since the alkali atomic number is high. Moreover, the more polarisable the alkali, the less bridging fluorines between the LaF(x) units...
  63. ncbi Plasma-membrane Cnh1 Na+/H+ antiporter regulates potassium homeostasis in Candida albicans
    Olga Kinclova-Zimmermannova
    Department of Membrane Transport, Institute of Physiology AS CR, v v i, Videnska 1083, 142 20 Prague 4 Krc, Czech Republic
    Microbiology 153:2603-12. 2007
    ..The potassium and rubidium tolerance of a cnh1 homozygous mutant was fully restored by reintegration of CNH1 into the genome...
  64. ncbi Comparison of K-Cl cotransport expression in high and low K dog erythrocytes
    Hideharu Ochiai
    Research Institute of Biosciences, Azabu University, Sagamihara, Kanagawa, Japan
    Exp Anim 55:57-63. 2006
    ..These results suggest that the difference in cotransport activity was not caused by the amount of K-Cl cotransport protein but by a difference in the regulation system, which is susceptible to oxidant...
  65. ncbi K(+) transport and volume regulatory response by NKCC in resting rat hindlimb skeletal muscle
    Michael I Lindinger
    Dept of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    Cell Physiol Biochem 12:279-92. 2002
    ..The hypertonic perfusate also resulted in temporally associated decreases in net water uptake by muscle. It is concluded that a functional NKCC is present in mammalian skeletal muscle and that it is involved in cell volume regulation...
  66. ncbi NhaK, a novel monovalent cation/H+ antiporter of Bacillus subtilis
    Makoto Fujisawa
    Graduate School of Life Sciences, Toyo University, 1 1 1 Izumino, Itakura machi, Oura gun, Gunma, 374 0193, Japan
    Arch Microbiol 183:411-20. 2005
    ..In addition, the expression level was significantly increased in the presence of added K+ and Na+...
  67. ncbi Selective binding of monovalent cations to the stacking G-quartet structure formed by guanosine 5'-monophosphate: a solid-state NMR study
    Alan Wong
    Department of Chemistry, Queen s University, Kingston, Ontario, Canada K7L 3N6
    J Am Chem Soc 125:13895-905. 2003
    ..We have demonstrated that solid-state (23)Na and (15)N NMR can be used simultaneously to provide mutually complementary information about competitive binding between Na(+) and NH(4)(+) ions...
  68. ncbi The selectivity filter of the tandem pore potassium channel TASK-1 and its pH-sensitivity and ionic selectivity
    K Yuill
    Molecular Physiology Group, Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK
    Pflugers Arch 448:63-9. 2004
    ..39+/-0.03 (n=14) in H98D, 0.64+/-0.04 (n=18) in D204H and 0.33+/-0.07 (n=3) in D204N. Thus, the arrangement of ring of residues HDHD appears to optimise both pH sensitivity and ionic selectivity...
  69. ncbi Sodium and potassium transport in the halophilic yeast Debaryomyces hansenii
    J C González-Hernández
    Departamento de Genetica y Biologia Molecular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Apartado 70 242, 04510 Mexico D F, Mexico
    Yeast 21:403-12. 2004
    ..It can be concluded that Na(+) in D. hansenii is not excluded but instead, its metabolic systems must be resistant to high salt concentrations...
  70. ncbi The schiff base of gossypol with 3,6,9,12,15,18,21,24-octaoxa-pentacosylamine complexes and monovalent cations studied by electrospray ionization-mass spectrometry, (1)H nuclear magnetic resonance, Fourier transform infrared, as well as PM5 semiempirical
    Piotr Przybylski
    Faculty of Chemistry, A Mickiewicz University, Grunwaldzka 6, 60 780 Poznan, Poland
    Biopolymers 74:273-86. 2004
    ..The two protons are localized on the N atoms of the Schiff base, and the complex exists in the imine-imine tautomeric form. The structures of the complexes are calculated by PM5 semiempirical methods and discussed...
  71. ncbi The TRK1 potassium transporter is the critical effector for killing of Candida albicans by the cationic protein, Histatin 5
    Didi Baev
    Department of Oral Biology, School of Dental Medicine, State University of New York, Buffalo, NY 14214, USA
    J Biol Chem 279:55060-72. 2004
    ..albicans...
  72. ncbi A role for the non-phosphorylated form of yeast Snf1: tolerance to toxic cations and activation of potassium transport
    Francisco Portillo
    Instituto de Investigaciones Biomedicas, Universidad Autónoma de Madrid C S I C, Arturo Duperier 4, 28029 Madrid, Spain
    FEBS Lett 579:512-6. 2005
    ..The effect of Snf1 on Trk is probably indirect and could be mediated by the Sip4 transcriptional activator...
  73. ncbi Regulation of potassium transport in human lens epithelial cells
    Peter K Lauf
    Cell Biophysics Group, Wright State University School of Medicine, Dayton, OH 45435, USA
    Exp Eye Res 82:55-64. 2006
    ..The data suggest at least partial inverse regulation of KCC and NKCC in HLE-B3 cells by signaling cascades involving serine, threonine and tyrosine phosphorylation/dephosphorylation equilibria...
  74. pmc Separation of P/C- and U-type inactivation pathways in Kv1.5 potassium channels
    Harley T Kurata
    Department of Cellular and Physiological Sciences, University of British Columbia, 2146 Health Sciences Mall, Vancouver B C V6T 1Z3, Canada
    J Physiol 568:31-46. 2005
    ..Collectively, these data distinguish between open-state and closed-state inactivation, and suggest the presence of multiple possible mechanisms of inactivation coexisting in Kv1 channels...
  75. doi Apparent intermediate K conductance channel hyposmotic activation in human lens epithelial cells
    Peter K Lauf
    Cell Biophysics Group, 054 Biological Sciences Bldg, Wright State Univ Boonshoft School of Medicine, Dayton, OH 45435, USA
    Am J Physiol Cell Physiol 294:C820-32. 2008
    ..1 channels, aside of the KCC1, KCC2, KCC3 and KCC4 isoforms. Apparently, IK channels, possibly in parallel with volume-sensitive outwardly rectifying Cl channels, effect regulatory volume decrease in LECs...
  76. pmc Ionic selectivity of native ATP-activated (P2X) receptor channels in dissociated neurones from rat parasympathetic ganglia
    D M Liu
    School of Biomedical Sciences, Department of Physiology and Pharmacology, University of Queensland, Brisbane, Queensland 4072, Australia
    J Physiol 534:423-35. 2001
    ..The relative permeabilities of the monovalent inoganic and organic cations tested are similar to those reported previously for cloned rat P2X(2) receptors expressed in mammalian cells...
  77. ncbi Entrance port for Na(+) and K(+) ions on Na(+),K(+)-ATPase in the cytoplasmic loop between trans-membrane segments M6 and M7 of the alpha subunit. Proximity Of the cytoplasmic segment of the beta subunit
    A Shainskaya
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel and Department of Biology, University of Konstanz, D-78434 Konstanz, Germany
    J Biol Chem 275:2019-28. 2000
    ..2) Na(+) ions specifically protect the 16-kDa fragment against this chymotryptic cleavage...
  78. ncbi Influence of permeating ions on Kv1.5 channel block by nifedipine
    S Lin
    Department of Physiology, University of British Columbia, 2146 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada
    Am J Physiol Heart Circ Physiol 280:H1160-72. 2001
    ..This is consistent with the conclusion that nifedipine block and C-type inactivation in the Kv1.5 channel can coexist but are mediated by distinct mechanisms coordinated by outer pore conformation...
  79. pmc Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments
    V Tereshko
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
    Nucleic Acids Res 29:1208-15. 2001
    ..Conversely, high resolution of the data alone does not necessarily allow differentiation between water and partially ordered metal ions, as demonstrated with the crystal structure of a DNA duplex determined to a resolution of 0.6 A...
  80. pmc The KCl cotransporter isoform KCC3 can play an important role in cell growth regulation
    M R Shen
    University Laboratory of Physiology, Parks Road, Oxford, OX1 3PT, United Kingdom
    Proc Natl Acad Sci U S A 98:14714-9. 2001
    ..Tumor necrotic factor-alpha down-regulates KCC3 expression and causes growth arrest. These data indicate that KCC3 is an important KCC isoform that may be involved in cell proliferation...
  81. ncbi Gating properties of inward-rectifier potassium channels: effects of permeant ions
    H Choe
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Membr Biol 184:81-9. 2001
    ..The patterns of voltage-dependence of closed-state lifetimes, which are specific for different ions, can be explained by variations in the rate at which the bound ions leave the pore toward the inside or the outside of the cell...
  82. pmc Multiple transport functions of a red blood cell anion exchanger, tAE1: its role in cell volume regulation
    H Guizouarn
    Laboratoire de Physiologie des Membranes Cellulaires, UMR 6078, , , 284 chemin du Lazaret, 06230 Villefranche-sur-Mer, France
    J Physiol 535:497-506. 2001
    ..6. tAE1 illustrates the ability of a specific transport system to be a multifunctional protein exhibiting other transport functions when submitted to regulation...
  83. ncbi A greater stimulation of Na-H antiport in cultured vascular smooth muscle cells by serum from spontaneously hypertensive rats
    S Kuriyama
    Second Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Am J Hypertens 4:780-2. 1991
    ..The study suggests that there are humoral factors in SHR serum which elicit the stimulation of the Na-H antiport, leading to the activation of the Na-K pump of VSMC...
  84. ncbi Fusicoccin- and IAA-induced elongation growth share the same pattern of K+ dependence
    K Tode
    , Ohnhorststr. 18, D-22609 Hamburg, Germany
    J Exp Bot 52:251-5. 2001
    ..However, TEA abolished this apparently K+ independent FC-induced growth. It is concluded that FC-induced growth, like auxin-induced growth, requires K+ uptake through K+ channels...
  85. pmc Sodium fluxes through nonselective cation channels in the plasma membrane of protoplasts from Arabidopsis roots
    Vadim Demidchik
    Department of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA United Kingdom
    Plant Physiol 128:379-87. 2002
    ..It is suggested that NSCCs present a distinct group of plant ion channels, mediating toxic Na(+) influx to the cell and probably having other important roles in physiological processes of plants...
  86. ncbi Capillary electrophoresis of anionic analytes in methanol: effect of counter-ions on electrophoretic mobility
    Simo P Porras
    Laboratory of Analytical Chemistry, Department of Chemistry, University of Helsinki, Helsinki, Finland
    Electrophoresis 23:367-74. 2002
    ..Exceptions are some di- and trihydroxybenzoates. The mobilities in methanol and in water with the same counter-ion (Na+) at a given ionic concentration show very low correlation...
  87. ncbi Potassium drives daily reversible thallus enlargement in the marine red alga Porphyra leucosticta (Rhodophyta)
    Luis Escassi
    Departamento de Ecologia, Universidad de Malaga, Campus Universitatio de Teatinos s n, 29071 Malaga, Spain
    Planta 214:759-66. 2002
    ..The possible effects of the loosening of the cell wall and the internal K+ concentration on the growth of this species are also discussed...
  88. pmc Inhibition of delayed rectifier K(+)-current by levcromakalim in single intestinal smooth muscle cells: effects of cations and dependence on K(+)-flux
    D McHugh
    Department of Pharmacology, University of Leeds
    Br J Pharmacol 114:391-9. 1995
    ....
  89. ncbi L-rhamnulose 1-phosphate aldolase from Escherichia coli. Crystallization and properties
    T H Chiu
    Biochemistry 8:98-108. 1969
  90. ncbi Molecular analysis of the mechanism of potassium uptake through the TRK1 transporter of Saccharomyces cerevisiae
    Rosario Haro
    Departamento de Biotecnologia, Escuela Tecnica Superior de Ingenieros Agronomos, Universidad Politecnica de Madrid, Spain
    Biochim Biophys Acta 1564:114-22. 2002
    ..ScTRK1 mediates active K(+) uptake. This is not Na(+)-coupled and direct coupling of ScTRK1 to a source of chemical energy seems more probable than K(+)-H(+) cotransport...
  91. pmc Fast network oscillations induced by potassium transients in the rat hippocampus in vitro
    Fiona E N LeBeau
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9NQ, UK
    J Physiol 542:167-79. 2002
    Brief pressure ejection of solutions containing potassium, caesium or rubidium ions into stratum radiatum of the CA1 or CA3 regions of the hippocampal slice evoked a fast network oscillation...
  92. ncbi Steady-state volumes and metabolism-independent osmotic adaptation in mammalian erythrocytes
    Peter Bogner
    Department of Clinical Chemistry, University of Pecs, Faculty of Medicine, Hungary
    Eur Biophys J 31:145-52. 2002
    ..The mobility of lipids within the hydrophobic inner layer of the plasma membrane relates closely to passive K(+) (Rb(+)) uptake, and plays a significant role in regulatory volume changes...
  93. pmc Formation of oriented molecular nanowires on mica surface
    Tomoyuki Akutagawa
    Research Institute for Electronic Science, Hokkaido University, Sapporo 060 0812, Japan
    Proc Natl Acad Sci U S A 99:5028-33. 2002
    ..Such correlation between the nanowires and the substrate surface was also observed when a dilute aqueous rubidium chloride subphase was used...
  94. ncbi Difference in substrate specificity divides the yeast alkali-metal-cation/H(+) antiporters into two subfamilies
    Olga Kinclová
    Department of Membrane Transport, Institute of Physiology CzAcadSci, 14220 Prague 4, Czech Republic
    Microbiology 148:1225-32. 2002
    ..rouxii...
  95. ncbi 7Li-NMR and FTIR studies of lithium, potassium, rubidium, and cesium complexes with ionophore lasalocid in solution
    R Pankiewicz
    Department of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, , Poland
    Biopolymers 62:173-82. 2001
    Lasalocid metal salts were combined with 1 : 1 lithium and 2:2 potassium, rubidium, and cesium to form complexes...
  96. ncbi Mutational effects on conformational changes of the dephospho- and phospho-forms of the Na+,K+-ATPase
    M Toustrup-Jensen
    Department of Physiology, University of Aarhus, , DK-8000 Aarhus C, Denmark
    Biochemistry 40:5521-32. 2001
    ....
  97. pmc Future direction of renal positron emission tomography
    Zsolt Szabo
    Division of Nuclear Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Semin Nucl Med 36:36-50. 2006
    ..may be even more useful in a clinical setting are those that either can be obtained from radionuclide generators (rubidium-82, copper-62) or have a sufficiently long half-life for transportation (fluorine-18)...
  98. ncbi Proceedings of the 13th Conference on Liquid and Amorphous Metals (LAM13) (Ekaterinburg, Russia, 8-14 July 2007)
    Pjotr Popel
    Ural State Pedagogical University
    J Phys Condens Matter 20:110301. 2008
  99. ncbi Ionic charge, radius, and potential control root/soil concentration ratios of fifty cationic elements in the organic horizon of a beech (Fagus sylvatica) forest podzol
    Germund Tyler
    Department of Ecology, Soil Plant Research, Ecology Building, SE 223 62 Lund, Sweden
    Sci Total Environ 329:231-9. 2004
    ..hafnium, mercury, holmium, indium, lanthanum, lithium, lutetium, niobium, neodymium, nickel, lead, praseodymium, rubidium, scandium, samarium, tin, terbium, thorium, titanium, thallium, thulium, uranium, vanadium, yttrium, ytterbium, ..
  100. ncbi Persistent organic pollutants and metals in the freshwater biota of the Canadian Subarctic and Arctic: an overview
    Marlene S Evans
    National Water Research Institute, Environment Canada, 11 Innovation Boulevard, Saskatoon, SK, Canada S7N 3H5
    Sci Total Environ 351:94-147. 2005
    ..Less research has been conducted on other metals but some, such as rubidium, show pronounced variations in concentration that may be related to geological influences...
  101. ncbi The effects of rubidium, caesium and quinine on 5-HT-mediated behaviour in rat and mouse--3. Quinine
    H Wang
    MRC Unit, Radcliffe Infirmary, Oxford, U K
    Neuropharmacology 31:425-31. 1992
    ..the basis of these findings, together with those in the preceding two papers, it is suggested that the effects of rubidium, caesium and quinine, to enhance differentially various aspects of 5-HT function are mediated by actions on 5-HT-..

Research Grants66

  1. Functional Brain Networks: A Novel Approach to Address Clinical Challenges in PD
    David Eidelberg; Fiscal Year: 2010
    ..responses, using [18F]-FDG PET (for cerebral metabolism), [150]-H20 PET (for cerebral blood flow), and [82Rb]-Rubidium PET (for BBB permeability) to compare levodopa-mediated changes across groups...
  2. PATHOGENESIS OF HERPETIC KERATITIS
    WILLIAM O BRIEN; Fiscal Year: 2002
    ..Pump function will be measured by rubidium uptake and enzyme activity by phosphate release from ATP...
  3. PATHOGENESIS OF HERPETIC KERATITIS
    WILLIAM O BRIEN; Fiscal Year: 2000
    ..Pump function will be measured by rubidium uptake and enzyme activity by phosphate release from ATP...
  4. PATHOGENESIS OF HERPETIC KERATITIS
    WILLIAM O BRIEN; Fiscal Year: 2001
    ..Pump function will be measured by rubidium uptake and enzyme activity by phosphate release from ATP...
  5. BIOCHEMICAL INTERACTIONS OF INSULIN WITH THE LENS
    John Coulter; Fiscal Year: 1980
    ..C14-amino acid incorporation into protein, C14-acetate incorporation into lipid, rubidium-86 uptake, and cyclic AMP content...
  6. MYOCARDIAL VIABILITY BY PET & PTCA/CAB TO IMPROVE LV EF
    K Gould; Fiscal Year: 1993
    ..necrosis, viability and zone at risk distal to all significant stenoses using a protocol combining resting rubidium washout with dipyridamole perfusion imaging...
  7. TRACE ELEMENT NUTRITION OF THE LENS--ZINC
    J Bentley; Fiscal Year: 1990
    ..by oxidative agents will be studied by, in vitro, by measuring changes in their permeability, using the isotope rubidium-86...
  8. Chronic Nicotine Effects on Receptor Subtypes
    David C Perry; Fiscal Year: 2010
    ..of chronic nicotine exposure on expression (using autoradiography and immunoprecipitation) and function (using rubidium efflux and neurotransmitter release) of nAChR subtypes, alteration of neuronal morphology (measuring dendritic ..
  9. Chronic Nicotine Effects on Receptor Subtypes
    David Perry; Fiscal Year: 2009
    ..of chronic nicotine exposure on expression (using autoradiography and immunoprecipitation) and function (using rubidium efflux and neurotransmitter release) of nAChR subtypes, alteration of neuronal morphology (measuring dendritic ..
  10. INORGANIC ION EXCHANGER FOR USE IN 82SR/82RB SEPARATIONS
    Paul Sylvester; Fiscal Year: 2000
    ..82Sr is produced by the irradiation of rubidium or molybdenum targets followed by the extraction of 82Sr using ion exchange techniques...
  11. Mechanisms of serum electrolyte effects on block of HERG
    Alan Miller; Fiscal Year: 2006
    ..channels or mutant HERG channels to study the mechanisms by which the extracellular monovalent cations potassium, rubidium, and cesium and the divalent cations calcium and magnesium alter block of HERG by a number of different compounds ..
  12. EFFECTS OF PRENATAL NICOTINE EXPOSURE ON BRAIN N-ACHR
    JAMES PAULY; Fiscal Year: 1993
    ..Striatal tissue will be used to measure nicotine-stimulated dopamine release; rubidium (a tracer for K+) flux will be used to measure functional responses of nAChr in other brain regions...
  13. FUNCTIONAL ACTIVITY OF MESOLIMBIC NICOTINIC RECEPTORS
    PETER ROWELL; Fiscal Year: 2001
    ..The nicotine-stimulated efflux of rubidium following various nicotine treatment schedules, coupled with assays of nicotine brain levels and receptors, will ..
  14. OPTIMIZED STRESS STATES IN CERAMIC-BASED RESTORATIONS
    Kenneth Anusavice; Fiscal Year: 2002
    ..prostheses, 3) single and double ion-exchange strengthening treatments based on potassium-enriched and rubidium-enriched slurries that are fired at low temperatures over short time periods, and 4) micro-miniature ..
  15. FUNCTIONAL ACTIVITY OF MESOLIMBIC NICOTINIC RECEPTORS
    PETER ROWELL; Fiscal Year: 2000
    ..The nicotine-stimulated efflux of rubidium following various nicotine treatment schedules, coupled with assays of nicotine brain levels and receptors, will ..
  16. OPTIMIZED STRESS STATES IN CERAMIC-BASED RESTORATIONS
    Kenneth Anusavice; Fiscal Year: 2000
    ..prostheses, 3) single and double ion-exchange strengthening treatments based on potassium-enriched and rubidium-enriched slurries that are fired at low temperatures over short time periods, and 4) micro-miniature ..
  17. OPTIMIZED STRESS STATES IN CERAMIC-BASED RESTORATIONS
    Kenneth Anusavice; Fiscal Year: 2001
    ..prostheses, 3) single and double ion-exchange strengthening treatments based on potassium-enriched and rubidium-enriched slurries that are fired at low temperatures over short time periods, and 4) micro-miniature ..
  18. OPTIMIZED STRESS STATES IN CERAMIC-BASED RESTORATIONS
    Kenneth Anusavice; Fiscal Year: 2003
    ..prostheses, 3) single and double ion-exchange strengthening treatments based on potassium-enriched and rubidium-enriched slurries that are fired at low temperatures over short time periods, and 4) micro-miniature ..
  19. OPTIMIZED STRESS STATES IN CERAMIC-BASED RESTORATIONS
    Kenneth Anusavice; Fiscal Year: 1999
    ..prostheses, 3) single and double ion-exchange strengthening treatments based on potassium-enriched and rubidium-enriched slurries that are fired at low temperatures over short time periods, and 4) micro-miniature ..
  20. FUNCTIONAL ACTIVITY OF MESOLIMBIC NICOTINIC RECEPTORS
    PETER ROWELL; Fiscal Year: 1999
    ..The nicotine-stimulated efflux of rubidium following various nicotine treatment schedules, coupled with assays of nicotine brain levels and receptors, will ..
  21. OPTIMIZED STRESS STATES IN CERAMIC-BASED RESTORATIONS
    Kenneth Anusavice; Fiscal Year: 2001
    ..prostheses, 3) single and double ion-exchange strengthening treatments based on potassium-enriched and rubidium-enriched slurries that are fired at low temperatures over short time periods, and 4) micro-miniature ..
  22. OPTIMIZED STRESS STATES IN CERAMIC-BASED RESTORATIONS
    Kenneth Anusavice; Fiscal Year: 2000
    ..prostheses, 3) single and double ion-exchange strengthening treatments based on potassium-enriched and rubidium-enriched slurries that are fired at low temperatures over short time periods, and 4) micro-miniature ..
  23. Scale Up of Hyperpolarized Xe Production
    Jan Distelbrink; Fiscal Year: 2009
    ..We will develop technology to monitor remaining rubidium and to sequester condensed rubidium, extending the service lifetime...
  24. EFFECT OF FLOW AND METABOLIC CHANGES ON CARDIAC ISOTOPES
    Jeffrey Leppo; Fiscal Year: 1990
    ..washout, extraction and compartmental distribution of several different perfusion agents (including thallium, rubidium, technetium labeled analogs of isonitriles and boronic acid adducts of technetium oximes [BATO's]) as well as ..
  25. Biochemistry of Normal & Abnormal Variants of Factors IX
    S Bajaj; Fiscal Year: 2003
    ..site, we will prepare EGF2-protease segment of FIXa and crystallize it in the presence of (a) sodium and (b) rubidium and determine its structure...
  26. Biochemistry of Normal & Abnormal Variants of Factors IX
    S Bajaj; Fiscal Year: 2003
    ..site, we will prepare EGF2-protease segment of FIXa and crystallize it in the presence of (a) sodium and (b) rubidium and determine its structure...
  27. Biochemistry of Normal & Abnormal Variants of Factors IX
    S Bajaj; Fiscal Year: 2005
    ..site, we will prepare EGF2-protease segment of FIXa and crystallize it in the presence of (a) sodium and (b) rubidium and determine its structure...
  28. Biochemistry of Normal & Abnormal Variants of Factors IX
    S Bajaj; Fiscal Year: 2004
    ..site, we will prepare EGF2-protease segment of FIXa and crystallize it in the presence of (a) sodium and (b) rubidium and determine its structure...
  29. Biochemistry of Normal & Abnormal Variants of Factors IX
    S Bajaj; Fiscal Year: 2005
    ..site, we will prepare EGF2-protease segment of FIXa and crystallize it in the presence of (a) sodium and (b) rubidium and determine its structure...
  30. Biochemistry of Normal & Abnormal Variants of Factors IX
    S Bajaj; Fiscal Year: 2006
    ..site, we will prepare EGF2-protease segment of FIXa and crystallize it in the presence of (a) sodium and (b) rubidium and determine its structure...
  31. OPTIMIZATION OF PET ESTIMATES OF MYOCARDIAL PERFUSION
    Steven Bergmann; Fiscal Year: 1991
    ..access to cyclotron-produced radiotracers and therefore use the generatorproduced extractable perfusion tracers rubidium-82 chloride and copper-62-pyruvaldehyde bis-N4-methylthiosemicarbazone (PTSM) for estimates of flow...
  32. FLOW, GLUCOSE METABOLISM AND MYOCARDIAL VIABILITY BY PET
    Richard Brunken; Fiscal Year: 1990
    ..kinetic models reparations with the goal of making accurate, noninvasive measurements of myocardial blood flow (rubidium-82, N-13 ammonia) and glucose utilization (F-18 deoxyglucose in vivo with PET...
  33. MODIFICATION OF TUMOR RESPONSE TO LOCAL IRRADIATION
    Jay Loeffler; Fiscal Year: 1980
    ..role of hypothermia (pentobarbital induces a hypothermia of about 4-6 degrees C), changes in blood flow (using rubidium extraction technique) and to assess the efficacy of anesthesia effect against oxygen produced lung damage...
  34. Microvascular Changes in Parkinson's Disease: Relationship to Levodopa-Induced Dy
    David Eidelberg; Fiscal Year: 2011
    ..responses, using [^F]-FDG PET (for cerebral metabolism), [^^0]-H20 PET (for cerebral blood flow), and [^Rb]-Rubidium PET (for BBB permeability) to compare levodopa-mediated changes across groups...
  35. Atomic Biomagnetometer
    THAD WALKER; Fiscal Year: 2005
    ..The specific aims are: 1. To build a optical magnetometer/gradiometer that utilizes rubidium atoms and achieves a magnetic field sensitivity 10A-14 T/(Hz)A1/2. 2...
  36. Atomic Biomagnetometer
    THAD WALKER; Fiscal Year: 2006
    ..The specific aims are: 1. To build a optical magnetometer/gradiometer that utilizes rubidium atoms and achieves a magnetic field sensitivity 10A-14 T/(Hz)A1/2. 2...
  37. NUCLEOTIDE CHANGES WITH AGGRESSION-ALTERING DRUGS
    Burr Eichelman; Fiscal Year: 1980
    ..g., 6-hydroxydopamine, monoamine oxidase inhibitors, dibenzazepines, and rubidium) and drugs which have been reported to decrease aggression (beta blockers, neuroleptics and lithium)...
  38. MAGNETIC RESONANCE IMAGING OF SLOW FLUID FLOW
    Samuel Patz; Fiscal Year: 1990
    ..Standard measurements of the perfusion (by microspheres and/or rubidium) in regions of the kidney, brain and skeletal muscle in the rabbit models will be compared with those obtained ..
  39. MAGNETIC RESONANCE IMAGING OF SLOW FLUID FLOW
    Samuel Patz; Fiscal Year: 1991
    ..Standard measurements of the perfusion (by microspheres and/or rubidium) in regions of the kidney, brain and skeletal muscle in the rabbit models will be compared with those obtained ..
  40. MYOCARDIUM INFARCT SIZING BY 82RB EMISSION TOMOGRAPHY
    STEPHEN DERENZO; Fiscal Year: 1980
    ..and resolution with which one can define myocardial infarction and ischemia using the positron emitting isotope rubidium-82 and carbon-11 amino acids. Rubidium-82 (75 sec...
  41. MECHANISM OF NONSPECIFIC SUPERSENSITIVITY TO DRUGS
    William Fleming; Fiscal Year: 1990
    ..g. radioactive ligand binding, rubidium uptake, assay of adenylate cyclase activity and cyclic AMP levels and measurement of Na+, K+ -ATPase activity)...
  42. Brain K+ Dynamics, BBB Breakdown & Hemorrhagic Transformation in Ischemic Stroke
    Stephen Jones; Fiscal Year: 2009
    ..We will use K/Rb substitution MRI to observe this [K+]brfall. Rubidium-87, but not K, can be effectively observed with MRI,acts as a congener of K+, and can be substituted for K (18%) ..
  43. Brain K+ Dynamics, BBB Breakdown & Hemorrhagic Transformation in Ischemic Stroke
    Stephen Jones; Fiscal Year: 2009
    ..We will use K/Rb substitution MRI to observe this [K+]brfall. Rubidium-87, but not K, can be effectively observed with MRI, acts as a congener of K+, and can be substituted for K (18%) ..
  44. Brain K+ Dynamics, BBB Breakdown & Hemorrhagic Transformation in Ischemic Stroke
    Stephen Jones; Fiscal Year: 2006
    ..We will use K/Rb substitution MRI to observe this [K+]brfall. Rubidium-87, but not K, can be effectively observed with MRI, acts as a congener of K+, and can be substituted for K (18%) ..
  45. Brain K+ Dynamics, BBB Breakdown & Hemorrhagic Transformation in Ischemic Stroke
    Stephen Jones; Fiscal Year: 2007
    ..We will use K/Rb substitution MRI to observe this [K+]brfall. Rubidium-87, but not K, can be effectively observed with MRI, acts as a congener of K+, and can be substituted for K (18%) ..
  46. SHORT TERM REGULATION OF THE NA+ PUMP
    Carlos Pedemonte; Fiscal Year: 2001
    ..and amino-terminus mutants of the rodent alpha subunit expressed in OK cells and will involve measurements of rubidium, ATPase activities and changes in intracellular sodium concentrations. The second aim has two parts...
  47. SHORT TERM REGULATION OF THE NA+ PUMP
    Carlos Pedemonte; Fiscal Year: 2000
    ..and amino-terminus mutants of the rodent alpha subunit expressed in OK cells and will involve measurements of rubidium, ATPase activities and changes in intracellular sodium concentrations. The second aim has two parts...
  48. SHORT TERM REGULATION OF THE NA+ PUMP
    Carlos Pedemonte; Fiscal Year: 1999
    ..and amino-terminus mutants of the rodent alpha subunit expressed in OK cells and will involve measurements of rubidium, ATPase activities and changes in intracellular sodium concentrations. The second aim has two parts...
  49. Third Symposium Cell Volume & Signalling Regulation
    PETER LAUF; Fiscal Year: 2003
    ..This meeting's success on U.S. soil will foster continuation of gathering of high-caliber scientists at subsequent international meetings ..
  50. Proteomics of M-L antigens modulating cation transport
    PETER LAUF; Fiscal Year: 2004
    ....
  51. From Clinic to Bench & Back: Clinical Biodetective Training (RMI)
    Mark Milanick; Fiscal Year: 2007
    ..e., approaches that can be used in family practice settings, by nurses and nurse practitioners, and by patients for selfmonitoring) in situations where the patient and clinician are not necessarily in a hospital setting. ..
  52. Infrastructure and Applications of Hyperpolarized 129Xe
    Samuel Patz; Fiscal Year: 2003
    ..A polarizer will be built, sited and supported at Brigham and Women's Hospital. Animal and human studies are proposed to demonstrate the structural and functional information 129Xe MRI can provide. ..
  53. ELECTROLYTE AND FLUID TRANSPORT IN OCULAR MEMBRANES
    OSCAR CANDIA; Fiscal Year: 1999
    ..These aims will extend recent original findings of this laboratory. From the accomplishment of these aims, models of lens and corneal physiological function will be provided. ..