ions

Summary

Summary: An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS.

Top Publications

  1. ncbi Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs
    Wan Seob Cho
    Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    Nanotoxicology 6:22-35. 2012
  2. ncbi Metal ions in biological catalysis: from enzyme databases to general principles
    Claudia Andreini
    Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019, Sesto Fiorentino, Italy
    J Biol Inorg Chem 13:1205-18. 2008
  3. ncbi Distribution, elimination, and toxicity of silver nanoparticles and silver ions in rats after 28-day oral exposure
    Meike Van Der Zande
    RIKILT Wageningen University and Research Centre, 6700 AE Wageningen, The Netherlands
    ACS Nano 6:7427-42. 2012
  4. ncbi Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents
    Philip L Ross
    Applied Biosystems, Framingham, MA 01701, USA
    Mol Cell Proteomics 3:1154-69. 2004
  5. ncbi Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles
    Wan Seob Cho
    ELEGI Colt Laboratory, Centre for Inflammation Research, University of Edinburgh, Edinburgh EH16 4TJ, UK
    Toxicol Sci 126:469-77. 2012
  6. pmc Relationships between growth, growth response to nutrient supply, and ion content using a recombinant inbred line population in Arabidopsis
    Aina E Prinzenberg
    Department of Plant Breeding and Genetics, Max Planck Institute for Plant Breeding Research, Cologne, Germany
    Plant Physiol 154:1361-71. 2010
  7. ncbi Physiological effects of nanoparticles on fish: a comparison of nanometals versus metal ions
    Benjamin J Shaw
    Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, University of Plymouth, Drake Circus, Plymouth, UK
    Environ Int 37:1083-97. 2011
  8. ncbi Predictive toxicology of cobalt nanoparticles and ions: comparative in vitro study of different cellular models using methods of knowledge discovery from data
    Limor Horev-Azaria
    Department of Physiology and Pharmacology, Faculty of Medicine, and the Marian Gertner Institute for Medical Nanosystems, Tel Aviv University, Tel Aviv 69978, Israel
    Toxicol Sci 122:489-501. 2011
  9. ncbi Alternate dissociation pathways identified in charge-reduced protein complex ions
    Kevin Pagel
    University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW, UK
    Anal Chem 82:5363-72. 2010
  10. pmc TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions
    Mahealani K Monteilh-Zoller
    Laboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen s Medical Center and John A Burns School of Medicine at the University of Hawaii, Honolulu, HI 96813, USA
    J Gen Physiol 121:49-60. 2003

Detail Information

Publications322 found, 100 shown here

  1. ncbi Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs
    Wan Seob Cho
    Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    Nanotoxicology 6:22-35. 2012
    ..NiONP recruited neutrophils only whilst NiOAE did not cause any inflammation. Understanding differences in the toxic role of the ionic components of metal oxide NPs will contribute to full hazard identification and characterisation...
  2. ncbi Metal ions in biological catalysis: from enzyme databases to general principles
    Claudia Andreini
    Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019, Sesto Fiorentino, Italy
    J Biol Inorg Chem 13:1205-18. 2008
    We analysed the roles and distribution of metal ions in enzymatic catalysis using available public databases and our new resource Metal-MACiE (http://www.ebi.ac.uk/thornton-srv/databases/Metal_MACiE/home.html)...
  3. ncbi Distribution, elimination, and toxicity of silver nanoparticles and silver ions in rats after 28-day oral exposure
    Meike Van Der Zande
    RIKILT Wageningen University and Research Centre, 6700 AE Wageningen, The Netherlands
    ACS Nano 6:7427-42. 2012
    ..However, the consequences of in vivo formation of silver nanoparticles, and of the long retention of silver in brain and testis should be considered in a risk assessment of silver nanoparticles...
  4. ncbi Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents
    Philip L Ross
    Applied Biosystems, Framingham, MA 01701, USA
    Mol Cell Proteomics 3:1154-69. 2004
    ..The derivatized peptides are indistinguishable in MS, but exhibit intense low-mass MS/MS signature ions that support quantitation...
  5. ncbi Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles
    Wan Seob Cho
    ELEGI Colt Laboratory, Centre for Inflammation Research, University of Edinburgh, Edinburgh EH16 4TJ, UK
    Toxicol Sci 126:469-77. 2012
    ..P is the electrical potential created between the surface of a particle, with its associated ions, and the medium it exists in and provides information concerning the particle surface charge...
  6. pmc Relationships between growth, growth response to nutrient supply, and ion content using a recombinant inbred line population in Arabidopsis
    Aina E Prinzenberg
    Department of Plant Breeding and Genetics, Max Planck Institute for Plant Breeding Research, Cologne, Germany
    Plant Physiol 154:1361-71. 2010
    ..These lines retained over 20% more rosette weight in reduced potassium supply, accompanied by an increase in potassium content in their leaves...
  7. ncbi Physiological effects of nanoparticles on fish: a comparison of nanometals versus metal ions
    Benjamin J Shaw
    Ecotoxicology Research and Innovation Centre, School of Biomedical and Biological Sciences, University of Plymouth, Drake Circus, Plymouth, UK
    Environ Int 37:1083-97. 2011
    ..dynamic aspects of aggregation theory, rather than the equilibrium models traditionally used for free metal ions. Some NPs, such as Cu-NPs, may also release free metal ions from the surface of the particle...
  8. ncbi Predictive toxicology of cobalt nanoparticles and ions: comparative in vitro study of different cellular models using methods of knowledge discovery from data
    Limor Horev-Azaria
    Department of Physiology and Pharmacology, Faculty of Medicine, and the Marian Gertner Institute for Medical Nanosystems, Tel Aviv University, Tel Aviv 69978, Israel
    Toxicol Sci 122:489-501. 2011
    ..The toxicological effects of cobalt nanoparticles (Co-NPs) aggregates were examined and compared with those of cobalt ions (Co-ions) using six different cell lines representing lung, liver, kidney, intestine, and the immune system...
  9. ncbi Alternate dissociation pathways identified in charge-reduced protein complex ions
    Kevin Pagel
    University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW, UK
    Anal Chem 82:5363-72. 2010
    ..Taken together, the results presented highlight the potential of charge state modulation as a method for directing the course of gas-phase dissociation and unfolding of protein complexes...
  10. pmc TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions
    Mahealani K Monteilh-Zoller
    Laboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen s Medical Center and John A Burns School of Medicine at the University of Hawaii, Honolulu, HI 96813, USA
    J Gen Physiol 121:49-60. 2003
    Trace metal ions such as Zn(2+), Fe(2+), Cu(2+), Mn(2+), and Co(2+) are required cofactors for many essential cellular enzymes, yet little is known about the mechanisms through which they enter into cells...
  11. pmc The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions
    Yuanyuan Y Wang
    Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 2520, USA
    J Biol Chem 283:32691-703. 2008
    ..In conclusion, we have further clarified the mechanisms of potentiation and inactivation of TRPA1 using the D918A pore mutant, an important tool for investigating the contribution of Ca(2+) influx through TRPA1 to nociceptive signaling...
  12. ncbi Sub-toxic effects of CuO nanoparticles on bacteria: kinetics, role of Cu ions and possible mechanisms of action
    Olesja Bondarenko
    Laboratory of Molecular Genetics, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia
    Environ Pollut 169:81-9. 2012
    ..specifically to (i) reactive oxygen species (ROS), (ii) single-stranded DNA breaks and (iii) bioavailable Cu ions. Using these sensors we showed that nano-CuO induces the formation of superoxide anions, hydrogen peroxide and ..
  13. ncbi Role of t-tubules in the control of trans-sarcolemmal ion flux and intracellular Ca2+ in a model of the rat cardiac ventricular myocyte
    M Pasek
    Institute of Thermomechanics Branch Brno, Academy of Sciences of the Czech Republic, Technicka 2, 616 69 Brno, Czech Republic
    Eur Biophys J 41:491-503. 2012
    ..The trans-sarcolemmal flux of many ions, including Ca(2+), occurs predominantly across the t-tubule membrane and thus into and out of this restricted ..
  14. ncbi Two-photon probes for intracellular free metal ions, acidic vesicles, and lipid rafts in live tissues
    Hwan Myung Kim
    Department of Chemistry, Korea University, Seoul, 136 701, Korea
    Acc Chem Res 42:863-72. 2009
    ..describe a series of two-photon probes that we developed that can visualize the distribution of intracellular metal ions, acidic vesicles, and lipid rafts in living cells and tissues...
  15. ncbi Evidence for macromolecular protein rings in the absence of bulk water
    Brandon T Ruotolo
    Department of Chemistry, Lensfield Road, University of Cambridge, Cambridge CB2 1EW, UK
    Science 310:1658-61. 2005
    ....
  16. pmc A computational model of the human left-ventricular epicardial myocyte
    Vivek Iyer
    The Center for Cardiovascular Bioinformatics and Modeling and The Whitaker Biomedical Engineering Institute, The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, Maryland 21093, USA
    Biophys J 87:1507-25. 2004
    ..The model therefore serves as a useful tool for investigating mechanisms of arrhythmia and consequences of drug-channel interactions in the human left-ventricular myocyte...
  17. pmc Substoichiometric levels of Cu2+ ions accelerate the kinetics of fiber formation and promote cell toxicity of amyloid-{beta} from Alzheimer disease
    Claire J Sarell
    School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, United Kingdom
    J Biol Chem 285:41533-40. 2010
    A role for Cu(2+) ions in Alzheimer disease is often disputed, as it is believed that Cu(2+) ions only promote nontoxic amorphous aggregates of amyloid-β (Aβ)...
  18. ncbi Mass spectrometric identification of proteins from silver-stained polyacrylamide gel: a method for the removal of silver ions to enhance sensitivity
    F Gharahdaghi
    The Rockefeller University Protein DNA Technology Center, New York, NY 10021, USA
    Electrophoresis 20:601-5. 1999
    ....
  19. pmc Neutralizing mutations of carboxylates that bind metal 2 in T5 flap endonuclease result in an enzyme that still requires two metal ions
    Christopher G Tomlinson
    Centre for Chemical Biology, Department of Chemistry, Krebs Institute, University of Sheffield, Sheffield S3 7HF, United Kingdom
    J Biol Chem 286:30878-87. 2011
    ..The spacing of the two metal ions observed in T5FEN structures appears to preclude this mechanism...
  20. ncbi Induction of protein oxidation by cobalt and chromium ions in human U937 macrophages
    Alain Petit
    Division of Orthopaedic Surgery, Lady Davis Institute for Medical Research, McGill University, The SMBD Jewish General Hospital, 3755 Ch Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    Biomaterials 26:4416-22. 2005
    Metal particles and ions from hip prostheses have the potential to induce the production of reactive oxygen species (ROS), making them prime suspects for disturbing the cellular balance of oxidants/antioxidants (redox state of the cell)...
  21. ncbi Silver ions induce oxidative stress and intracellular zinc release in human skin fibroblasts
    Miriam M Cortese-Krott
    Department of Internal Medicine B, Cardiovascular Research Laboratory, Medical Faculty of the Heinrich Heine University Düsseldorf, D 40225 Dusseldorf, Germany
    Free Radic Biol Med 47:1570-7. 2009
    ..The aim of this study was to investigate whether the toxicity of silver ions, in analogy to other transition metal ions, depends on pro-oxidant effects...
  22. ncbi Enhanced osteocalcin expression by osteoblast-like cells (MC3T3-E1) exposed to bioactive coating glass (SiO2-CaO-P2O5-MgO-K2O-Na2O system) ions
    V G Varanasi
    Division of Biomaterials and Bioengineering, University of California, San Francisco, CA 94143 0758, USA
    Acta Biomater 5:3536-47. 2009
    ..The ions from experimental bioactive glass (6P53-b) and commercial Bioglass(TM) (45S5) were added to osteoblast-like MC3T3-..
  23. ncbi Quantifying the origin of released Ag+ ions from nanosilver
    Georgios A Sotiriou
    Particle Technology Laboratory, Institute of Process Engineering, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland
    Langmuir 28:15929-36. 2012
    ..Concerns, however, about released Ag(+) ions during dispersion of nanosilver in liquids have limited its broad use...
  24. ncbi Temperature-responsive ionic liquid/water interfaces: relation between hydrophilicity of ions and dynamic phase change
    Yuki Kohno
    Department of Biotechnology, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184 8588, Japan
    Phys Chem Chem Phys 14:5063-70. 2012
    ..Potential application of the LCST-type phase change to the selective extraction of water-soluble proteins is also summarised...
  25. ncbi Graphene oxide papers modified by divalent ions-enhancing mechanical properties via chemical cross-linking
    Sungjin Park
    Department of Mechanical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208 3111, USA
    ACS Nano 2:572-8. 2008
    ..of the chemical interactions between the functional groups of the graphene oxide sheets and the divalent metals ions. While oxygen functional groups on the basal planes of the sheets and the carboxylate groups on the edges can both ..
  26. pmc A study of the hydration of the alkali metal ions in aqueous solution
    Johan Mähler
    Department of Chemistry, Swedish University of Agricultural Sciences, P O Box 7015, SE 750 07 Uppsala, Sweden
    Inorg Chem 51:425-38. 2012
    The hydration of the alkali metal ions in aqueous solution has been studied by large angle X-ray scattering (LAXS) and double difference infrared spectroscopy (DDIR)...
  27. ncbi Therapeutic redistribution of metal ions to treat Alzheimer's disease
    Peter J Crouch
    Department of Pathology, University of Melbourne, Victoria, Australia
    Acc Chem Res 45:1604-11. 2012
    ..strategy that incorporates diverse compounds with a common characteristic: the ability to redistribute metal ions within the brain...
  28. pmc Electrochemical microsensors for the detection of cadmium(II) and lead(II) ions in plants
    Olga Krystofova
    Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Zemedelska 1, CZ 613 00 Brno, Czech Republic
    Sensors (Basel) 10:5308-28. 2010
    ..and a homemade micropotentiostat] for easy-to-use and sensitive determination of cadmium(II) and lead(II) ions. The lowest detection limits (hundreds of pM) for both metals was achieved by using of the standard potentiostat, ..
  29. ncbi Traveling-wave ion mobility mass spectrometry of protein complexes: accurate calibrated collision cross-sections of human insulin oligomers
    Rune Salbo
    Diabetes Protein Engineering, Novo Nordisk A S, Novo Nordisk Park, Måløv, Denmark
    Rapid Commun Mass Spectrom 26:1181-93. 2012
    ..The T-wave Ω-values depend strongly on instrument parameters and calibrant selection. Optimization of instrument parameters and calibration standards are crucial for obtaining accurate T-wave Ω-values...
  30. ncbi Complexation of metal ions with TRAP (1,4,7-triazacyclononane phosphinic acid) ligands and 1,4,7-triazacyclononane-1,4,7-triacetic acid: phosphinate-containing ligands as unique chelators for trivalent gallium
    Jakub Simeček
    Department of Inorganic Chemistry, Univerzita Karlova Charles University, Hlavova 2030, 12843 Prague 2, Czech Republic
    Inorg Chem 51:577-90. 2012
    ..constants of ligands and stability constants of their complexes with Ga(3+), selected divalent metal, and Ln(3+) ions were determined by potentiometry...
  31. ncbi Comparison of efficacy and toxicity of short-course carbon ion radiotherapy for hepatocellular carcinoma depending on their proximity to the porta hepatis
    Hiroshi Imada
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Radiother Oncol 96:231-5. 2010
    ..To compare the efficacy and toxicity of short-course carbon ion radiotherapy (C-ion RT) for patients with hepatocellular carcinoma (HCC) in terms of tumor location: adjacent to the porta hepatis or not...
  32. pmc Treatment of patients with atypical meningiomas Simpson grade 4 and 5 with a carbon ion boost in combination with postoperative photon radiotherapy: the MARCIE trial
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 10:615. 2010
    ..Carbon ions offer physical and biological characteristics...
  33. pmc Dynamics of pyrophosphate ion release and its coupled trigger loop motion from closed to open state in RNA polymerase II
    Lin Tai Da
    Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
    J Am Chem Soc 134:2399-406. 2012
    ..Our simulations provide predictions to guide future experimental tests...
  34. pmc The competition of charge remote and charge directed fragmentation mechanisms in quaternary ammonium salt derivatized peptides--an isotopic exchange study
    Marzena Cydzik
    Faculty of Chemistry, University of Wrocław, F Joliot Curie 14, 50 383 Wrocław, Poland
    J Am Soc Mass Spectrom 22:2103-7. 2011
    ..The isotopic labeling allows differentiation of fragments formed according to ChR and ChD mechanisms...
  35. ncbi Effect of metal ions (Li+, Na+, K+, Mg2+, Ca2+, Ni2+, Cu2+ and Zn2+) and water coordination on the structure and properties of L-histidine and zwitterionic L-histidine
    Milan Remko
    Department of Pharmaceutical Chemistry, Comenius University, Odbojarov 10, 832 32, Bratislava, Slovakia
    Amino Acids 39:1309-19. 2010
    Interactions between metal ions and amino acids are common both in solution and in the gas phase. The effect of metal ions and water on the structure of L-histidine is examined...
  36. ncbi Salt dependence of ion transport and DNA translocation through solid-state nanopores
    Ralph M M Smeets
    Kavli Institute of Nanoscience, Delft University of Technology, The Netherlands
    Nano Lett 6:89-95. 2006
    ..We demonstrate that the two competing effects cancel at a KCl concentration of 370 +/- 40 mM...
  37. ncbi Ionomics and the study of the plant ionome
    David E Salt
    Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907, USA
    Annu Rev Plant Biol 59:709-33. 2008
    ..In this review we describe the analytical and bioinformatics aspects of ionomics, as well as its application as a functional genomics tool...
  38. ncbi Repair kinetics of DNA-DSB induced by X-rays or carbon ions under oxic and hypoxic conditions
    Ryoichi Hirayama
    Graduate School of Science and Technology, Chiba University, Yayoi cho 1 33, Inage Ku, Chiba 163 8522, Japan
    J Radiat Res 46:325-32. 2005
    ..CHO cells were exposed to 200 kVp X-rays or 80 keV/microm carbon ions under oxic and hypoxic conditions. DNA-DSB in the cells were analyzed by a static-field gel electrophoresis (SFGE)...
  39. ncbi Diagnostic ions for the rapid analysis by nano-electrospray ionization quadrupole time-of-flight mass spectrometry of O-glycans from human mucins
    Catherine Robbe
    Unité Mixte de Recherche CNRS USTL 8576, Glycobiologie Structurale et Fonctionnelle, IFR 118, Université des Sciences et Technologies de Lille 1, 59655 Villeneuve d Ascq cedex, France
    Rapid Commun Mass Spectrom 18:412-20. 2004
    ..amounts of oligosaccharides previously analyzed by nuclear magnetic resonance (NMR), series of diagnostic ions relevant to the structural characterization of O-glycans were deduced...
  40. ncbi Stable prenucleation calcium carbonate clusters
    Denis Gebauer
    Max Planck Institute of Colloids and Interfaces, Research Campus Golm, Am Muhlenberg 1, D 14424 Potsdam, Germany
    Science 322:1819-22. 2008
    ..Huge amounts of carbon dioxide are retained as carbonate ions, and calcium ions represent a major contribution to water hardness...
  41. ncbi Direct observation of charge inversion by multivalent ions as a universal electrostatic phenomenon
    K Besteman
    Kavli Institute of Nanoscience, Delft University of Technology, 2628 CJ Delft, The Netherlands
    Phys Rev Lett 93:170802. 2004
    ..observed reversal of the polarity of charged surfaces in water upon the addition of trivalent and quadrivalent ions using atomic force microscopy...
  42. pmc Improved pKa calculations through flexibility based sampling of a water-dominated interaction scheme
    Jim Warwicker
    Department of Biomolecular Sciences, UMIST, P O Box 88, Manchester M60 1QD, UK jim
    Protein Sci 13:2793-805. 2004
    ....
  43. ncbi Skull base chordomas: efficacy of surgery followed by carbon ion radiotherapy
    Satoshi Takahashi
    Department of Neurosurgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Acta Neurochir (Wien) 151:759-69. 2009
    ..We report the effectiveness of combined radical skull base surgery with carbon ion radiotherapy for treating skull base chordomas...
  44. pmc Structure and phase diagram of nucleosome core particles aggregated by multivalent cations
    Aurelie Bertin
    Laboratoire de Physique des Solides, CNRS UMR 8502, Université Orsay Sud, Paris, France
    Biophys J 93:3652-63. 2007
    ..We address the question of the effect of multivalent ions on the interactions and mutual organization of the chromatin structural units, the nucleosome core particles (NCPs)...
  45. ncbi Metal binding and base ionization in the U6 RNA intramolecular stem-loop structure
    Anna Huppler
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, Wisconsin 53706, USA
    Nat Struct Biol 9:431-5. 2002
    ..A wobble pair. Protonation of the C.A pair and metal binding are mutually antagonistic. These results support a ribozyme model for U6 RNA function and suggest a possible mechanism for the regulation of RNA splicing...
  46. ncbi Studies of signal suppression in liquid chromatography-electrospray ionization mass spectrometry using volatile ion-pairing reagents
    S A Gustavsson
    Department of Organic Chemistry, Institute of Chemistry, Uppsala University, Sweden
    J Chromatogr A 937:41-7. 2001
    ..Finally, the long-term performance of the ESI interface and the chemical background caused by these fluorinated reagents were examined. No degradation of the ESI interface performance could be seen for over 24 h of continuous infusion...
  47. ncbi Chemiluminescent and chemiluminescence resonance energy transfer (CRET) detection of DNA, metal ions, and aptamer-substrate complexes using hemin/G-quadruplexes and CdSe/ZnS quantum dots
    Ronit Freeman
    Institute of Chemistry, Center of Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Am Chem Soc 133:11597-604. 2011
    ..the horseradish peroxidase (HRP)-mimicking DNAzyme and aptamer domains against ATP or sequences recognizing Hg(2+) ions self-assemble, in the presence of ATP or Hg(2+), into the active hemin-G-quadruplex DNAzyme structure...
  48. ncbi Determination of ion structures in structurally related compounds using precursor ion fingerprinting
    Michelle T Sheldon
    Commonwealth of Virginia, Department of General Services, Division of Consolidated Laboratory Services, Richmond, Virginia 23219, USA
    J Am Soc Mass Spectrom 20:370-6. 2009
    ..PIF is a new approach for interpreting and library-searching ESI mass spectra predicated on the precursor ions of structurally-related compounds and their matching product ion spectra...
  49. ncbi Heidelberg Ion Therapy Center (HIT): Initial clinical experience in the first 80 patients
    Stephanie E Combs
    University Hospital of Heidelberg, Department of Radiation Oncology, 69120 Heidelberg, Germany
    Acta Oncol 49:1132-40. 2010
    ..In this report we present the first 80 patients treated with proton and carbon ion radiotherapy and describe patient selection, treatment planning and daily treatment for different indications...
  50. ncbi Role of halide ions and temperature on the morphology of biologically synthesized gold nanotriangles
    Akhilesh Rai
    Nanoscience Group, Materials Chemistry Division, National Chemical Laboratory, Pune 411 008, India
    Langmuir 22:736-41. 2006
    In this paper, we demonstrate the effect of halide ions on the formation of biogenically prepared gold nanotriangles using the leaf extract of lemongrass (Cymbopogon flexuosus) plant...
  51. ncbi Ion suppression in mass spectrometry
    Thomas M Annesley
    Department of Pathology, University of Michigan Medical Center, Ann Arbor, MI 48109 0054, USA
    Clin Chem 49:1041-4. 2003
    ..It provides specificity because of its ability to monitor selected mass ions, sensitivity because of the enhanced signal-to-noise ratio, and speed because it can help avoid the need for ..
  52. ncbi Bridging like-charged macroions through long divalent rodlike ions
    Sylvio May
    Department of Physics, North Dakota State University, Fargo, ND 58105 5566, USA
    J Phys Chem B 112:1685-92. 2008
    ..if the spatially extended structure (which reflects the presence of intramolecular correlations) of the mobile ions in the electrolyte is accounted for...
  53. ncbi Measurement of selected ions related to oxidative stress and energy metabolism in Saudi autistic children
    Afaf El-Ansary
    Biochemistry Department, Science College, King Saud University, PO Box 22452, Zip code 11495, Riyadh, Saudi Arabia
    Clin Biochem 43:63-70. 2010
    ..This study aims to clarify the role of selected ions related to energy metabolism as a consequence of oxidative stress in the deterioration accompanied autism.
  54. pmc RNA folding: thermodynamic and molecular descriptions of the roles of ions
    David E Draper
    Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Biophys J 95:5489-95. 2008
    The stability of a compact RNA tertiary structure is exquisitely sensitive to the concentrations and types of ions that are present...
  55. pmc Substrate binding and formation of an occluded state in the leucine transporter
    Leyla Celik
    Department of Biochemistry, Center for Biophysics and Computational Biology, and Beckman Institute, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    Biophys J 94:1600-12. 2008
    ..simulations have been performed on different combinations of LeuT, bound substrate, and bound structural Na(+) ions to describe molecular events involved in substrate binding and in the formation of the occluded state and to ..
  56. ncbi Chloride ions control the G1/S cell-cycle checkpoint by regulating the expression of p21 through a p53-independent pathway in human gastric cancer cells
    Hiroaki Miyazaki
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 366:506-12. 2008
    ..These observations indicate that chloride ions play important roles in cell-cycle progression by regulating the expression of p21 through a p53-independent ..
  57. ncbi Electrostatic mechanisms of DNA deformation
    L D Williams
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta 30332 0400, USA
    Annu Rev Biophys Biomol Struct 29:497-521. 2000
    ..The intrinsic physical properties of DNA, as well as the properties of its complexes with proteins and ions, are therefore of fundamental interest in understanding the functions of DNA as an informational macromolecule...
  58. pmc Two mechanisms of ion selectivity in protein binding sites
    Haibo Yu
    Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 107:20329-34. 2010
    ..are negligible, the ion and ligands behave as a "confined microdroplet" that is free to fluctuate and adapt to ions of different sizes...
  59. pmc K+ transport by the OsHKT2;4 transporter from rice with atypical Na+ transport properties and competition in permeation of K+ over Mg2+ and Ca2+ ions
    Tomoaki Horie
    Division of Applied Biology, Faculty of Textile Science and Technology, Shinshu University, Ueda, Nagano 386 8567, Japan
    Plant Physiol 156:1493-507. 2011
    ..OsHKT2;4-mediated currents exhibited permeabilities to both Mg(2+) and Ca(2+) in the absence of competing K(+) ions. Comparative analyses of Ca(2+) and Mg(2+) permeabilities in several HKT transporters, including Arabidopsis ..
  60. pmc Imaging of lipid species by MALDI mass spectrometry
    Robert C Murphy
    Department of Pharmacology, MS 8303 University of Colorado Denver, Aurora, CO 80045, USA
    J Lipid Res 50:S317-22. 2009
    ..Abundant lipid-related ions are produced from the direct analysis of thin tissue slices when sequential spectra are acquired across a tissue ..
  61. pmc Nanoscale live-cell imaging using hopping probe ion conductance microscopy
    Pavel Novak
    Imperial College London, UK
    Nat Methods 6:279-81. 2009
    ..The technique allowed examination of nanoscale phenomena on the surface of live cells under physiological conditions...
  62. ncbi Copper(II) binding to amyloid-beta fibrils of Alzheimer's disease reveals a picomolar affinity: stoichiometry and coordination geometry are independent of Abeta oligomeric form
    Claire J Sarell
    School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, UK
    Biochemistry 48:4388-402. 2009
    Cu(2+) ions are found concentrated within senile plaques of Alzheimer's disease patients directly bound to amyloid-beta peptide (Abeta) and are linked to the neurotoxicity and self-association of Abeta...
  63. ncbi The implications of proteolytic background for shotgun proteomics
    Paola Picotti
    Institute of Molecular Systems Biology, ETH Zurich, CH 8093, Zurich, Switzerland
    Mol Cell Proteomics 6:1589-98. 2007
    ....
  64. pmc MINAS--a database of Metal Ions in Nucleic AcidS
    Joachim Schnabl
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Nucleic Acids Res 40:D434-8. 2012
    ..g. in ribozymes, also the catalytic mechanism. The database MINAS, Metal Ions in Nucleic AcidS (http://www.minas.uzh...
  65. pmc Exploring the surface sensitivity of TOF-secondary ion mass spectrometry by measuring the implantation and sampling depths of Bi(n) and C60 ions in organic films
    Shin Muramoto
    National ESCA and Surface Analysis Center for Biomedical Problems, University of Washington, Seattle, Washington 98195, USA
    Anal Chem 84:365-72. 2012
    The surface sensitivity of Bi(n)(q+) (n = 1, 3, 5, q = 1, 2) and C(60)(q+) (q = 1, 2) primary ions in static time-of-flight secondary ion mass spectrometry (TOF-SIMS) experiments were investigated for molecular trehalose and polymeric ..
  66. ncbi Equilibrium and kinetics studies of heavy metal ions biosorption on green algae waste biomass
    Dumitru Bulgariu
    Al I Cuza University of Iasi, Faculty of Geography and Geology, Department of Geology and Geochemistry, Romania
    Bioresour Technol 103:489-93. 2012
    ..The results indicate that Langmuir model provide best correlation of experimental data, and the pseudo-second order kinetic equation could best describe the biosorption kinetics of considered heavy metals...
  67. ncbi Improvement of osseointegration of titanium dental implant surfaces modified with CO ions: a comparative histomorphometric study in beagle dogs
    M A De Maeztu
    Int J Oral Maxillofac Surg 37:441-7. 2008
    ..001 and p=0.032) at 3 and 6 months, respectively. No significant differences were observed between the three groups of commercially treated implants. The larger %BIC of the ion-implanted group was observable at an early stage...
  68. pmc Ion exclusion by sub-2-nm carbon nanotube pores
    Francesco Fornasiero
    Chemistry Materials Earth and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Proc Natl Acad Sci U S A 105:17250-5. 2008
    ..Our results strongly support a Donnan-type rejection mechanism, dominated by electrostatic interactions between fixed membrane charges and mobile ions, whereas steric and hydrodynamic effects appear to be less important.
  69. ncbi Soluble ions more than particulate cobalt-alloy implant debris induce monocyte costimulatory molecule expression and release of proinflammatory cytokines critical to metal-induced lymphocyte reactivity
    Marco S Caicedo
    Department of Immunology, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Biomed Mater Res A 93:1312-21. 2010
    ..implicated as the major type of implant debris mediating macrophage-induced osteolysis, the degree to which metal ions affect a proinflammatory response (if at all) remains unknown...
  70. ncbi Visual sensor for the detection of trace Cu(II) ions using an immunochromatographic strip
    Changrui Xing
    School of Food Science and Technology, State Key Lab of Food Science and Technology, Jiangnan University, Wuxi, 214122, China
    Immunol Invest 42:221-34. 2013
    ..In optimized conditions, the visual limit of detection for qualitative detection of Cu(II) ions was 10 ng/mL and the LOD for semi-quantitative detection decreased to 0...
  71. ncbi Effect of iron ions on functional activity of thrombin
    O A Azizova
    Laboratory for Biophysical Bases of Pathology, Institute of Physicochemical Medicine, Russian Ministry of Health, Moscow, Russia
    Bull Exp Biol Med 148:776-9. 2009
    The kinetics of thrombin inhibition by irons ions was studied in the thrombin time test with normal plasma...
  72. ncbi Applications of a travelling wave-based radio-frequency-only stacked ring ion guide
    Kevin Giles
    Waters MS Technologies Centre, Micromass UK Ltd, Floats Road, Wythenshawe, Manchester M23 9LZ, UK
    Rapid Commun Mass Spectrom 18:2401-14. 2004
    The use of radio-frequency (RF)-only ion guides for efficient transport of ions through regions of a mass spectrometer where the background gas pressure is relatively high is widespread in present instrumentation...
  73. pmc Dynamics of water interacting with interfaces, molecules, and ions
    Michael D Fayer
    Department of Chemistry, Stanford University, California 94305, United States
    Acc Chem Res 45:3-14. 2012
    ..hydrogen bond structural dynamics can be substantially influenced by the presence of, for example, interfaces, ions, and large molecules...
  74. ncbi Ions at the air-water interface: an end to a hundred-year-old mystery?
    Yan Levin
    Instituto de Fisica, Universidade Federal do Rio Grande do Sul, Caixa Postal 15051, CEP 91501 970, Porto Alegre, RS, Brazil
    Phys Rev Lett 103:257802. 2009
    Availability of highly reactive halogen ions at the surface of aerosols has tremendous implications for the atmospheric chemistry...
  75. ncbi The cementogenic differentiation of periodontal ligament cells via the activation of Wnt/β-catenin signalling pathway by Li+ ions released from bioactive scaffolds
    Pingping Han
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia
    Biomaterials 33:6370-9. 2012
    ..Li(+) ions are thought to enhance the remyelination of peripheral nerves and also stimulate the proliferation of neural ..
  76. ncbi Toward efficient binders for Li-ion battery Si-based anodes: polyacrylic acid
    Alexandre Magasinski
    School of Materials Science and Engineering and School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA
    ACS Appl Mater Interfaces 2:3004-10. 2010
    ..01 and 1 V vs Li/Li+ and containing as little as 15 wt % of PAA, showed excellent stability during the first hundred cycles. The results obtained open new avenues to explore a novel series of binders from the polyvinyl acids (PVA) family...
  77. ncbi Neutral pH and copper ions promote eumelanogenesis after the dopachrome stage
    Shosuke Ito
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    Pigment Cell Melanoma Res 26:817-25. 2013
    ..The effects of Cu(2+) ions on those reactions were also compared...
  78. ncbi Adsorption and cosorption of tetracycline and copper(II) on montmorillonite as affected by solution pH
    Yu Jun Wang
    State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China
    Environ Sci Technol 42:3254-9. 2008
    ..Addition of Cu(ll) ions increased TC adsorption on the mineral in a wide range of pH...
  79. ncbi Ion mobility mass spectrometry of proteins and protein assemblies
    Charlotte Uetrecht
    Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Chem Soc Rev 39:1633-55. 2010
    ..to mass spectrometry providing a new dimension in the analysis of biomolecules, with ion mobility separating ions according to differences in size and shape...
  80. ncbi Elemental composition determination based on MS(n)
    Miguel Rojas-Chertó
    Netherlands Metabolomics Centre, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Bioinformatics 27:2376-83. 2011
    ..High-resolution mass spectrometry, which provides the exact mass, together with common constraint rules, for rejecting false proposed elemental compositions, cannot always provide one unique elemental composition solution...
  81. ncbi Evidence for structural variants of a- and b-type peptide fragment ions using combined ion mobility/mass spectrometry
    Isabel Riba-Garcia
    Michael Barber Centre for Mass Spectrometry, School of Chemistry and Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, UK
    J Am Soc Mass Spectrom 19:609-13. 2008
    ..Not all the fragment ions observed by low-energy collision-induced dissociation of protonated peptides are readily explained by the generally ..
  82. pmc Cycle flux algebra for ion and water flux through the KcsA channel single-file pore links microscopic trajectories and macroscopic observables
    Shigetoshi Oiki
    Department of Molecular Physiology and Biophysics, University of Fukui Faculty of Medical Sciences, Fukui, Japan
    PLoS ONE 6:e16578. 2011
    In narrow pore ion channels, ions and water molecules diffuse in a single-file manner and cannot pass each other...
  83. pmc Combined treatment of malignant salivary gland tumours with intensity-modulated radiation therapy (IMRT) and carbon ions: COSMIC
    Alexandra D Jensen
    Dept, of Radiation Oncology, INF 400, 69120 Heidelberg, Germany
    BMC Cancer 10:546. 2010
    ....
  84. pmc Determination of the Na(+)/glucose cotransporter (SGLT1) turnover rate using the ion-trap technique
    Jean Philippe Longpré
    Groupe d étude des protéines membranaires GÉPROM, Departement de Physique, Universite de Montreal, Montreal, Quebec, Canada
    Biophys J 100:52-9. 2011
    The Na(+)/glucose cotransporter (SGLT1) is a membrane protein that couples the transport of two Na(+) ions and one glucose molecule using the so-called alternating access mechanism...
  85. pmc LC-MSsim--a simulation software for liquid chromatography mass spectrometry data
    Ole Schulz-Trieglaff
    International Max Planck Research School for Computational Biology and Scientific Computing, Berlin, Germany
    BMC Bioinformatics 9:423. 2008
    ..So far, curated benchmark data exists only for peptide identification algorithms but no data that represents a ground truth for the evaluation of feature detection, alignment and filtering algorithms...
  86. pmc Dimensions and ion selectivity of recombinant AMPA and kainate receptor channels and their dependence on Q/R site residues
    N Burnashev
    Max Planck Institut fur medizinische Forschung, Abteilung Zellphysiologie, Heidelberg, Germany
    J Physiol 496:165-73. 1996
    ..Therefore, the differences in the anion versus cation selectivity, in Ca2+ permeability and in channel conductance are likely to be determined by the difference in charge density of the channel...
  87. pmc Randomised phase I/II study to evaluate carbon ion radiotherapy versus fractionated stereotactic radiotherapy in patients with recurrent or progressive gliomas: the CINDERELLA trial
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 10:533. 2010
    ..Carbon ions offer physical and biological characteristics...
  88. ncbi Electrical detection of metal ions using field-effect transistors based on micropatterned reduced graphene oxide films
    Herry Gunadi Sudibya
    School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, Singapore
    ACS Nano 5:1990-4. 2011
    ..Such a nanoelectronic sensor is able to detect various metal ions in real-time with high sensitivity.
  89. ncbi Exploring the precursor ion exclusion feature of liquid chromatography-electrospray ionization quadrupole time-of-flight mass spectrometry for improving protein identification in shotgun proteome analysis
    Nan Wang
    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada
    Anal Chem 80:4696-710. 2008
    ..This strategy is based on running replicates of the sample where the precursor ions detected in the initial run(s) are excluded for MS/MS in the subsequent run...
  90. ncbi Generalized stern models of the electric double layer considering the spatial variation of permittvity and finite size of ions in saturation regime
    Ekaterina Gongadze
    Institute of General Electrical Engineering, University of Rostock, Albert Einstein Straße 2, 18051, Rostock, Germany
    Cell Mol Biol Lett 16:576-94. 2011
    ..introduce two Langevin models for spatial variation of the relative permittivity for point-like and finite sized ions. We attempt to uncover the subtle interplay between water ordering and finite sized ions and their impact on the ..
  91. ncbi Influence of size on apparent scrambling of sequence during CID of b-type ions
    Samuel Molesworth
    Department of Chemistry, Wichita State University, Wichita, Kansas 67260 0051, USA
    J Am Soc Mass Spectrom 20:2174-81. 2009
    ..the influence of peptide size on the apparent loss of sequence during collision-induced dissociation (CID) of b ions using a group of peptides containing from between 4 and 10 residues...
  92. pmc Inorganic phosphate and sodium ions are cogerminants for spores of Clostridium perfringens type A food poisoning-related isolates
    Daniel Paredes-Sabja
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon 97331, USA
    Appl Environ Microbiol 75:6299-305. 2009
    ..Previously, we showed that only spores of FP isolates were able to germinate with K(+) ions. We now found that the spores of the majority of FP isolates, but none of the NFB isolates, germinated with the ..
  93. ncbi Towards understanding the tandem mass spectra of protonated oligopeptides. 2: The proline effect in collision-induced dissociation of protonated Ala-Ala-Xxx-Pro-Ala (Xxx = Ala, Ser, Leu, Val, Phe, and Trp)
    Christian Bleiholder
    Department of Molecular Biophysics, German Cancer Research Center DKFZ, Heidelberg, Germany
    J Am Soc Mass Spectrom 22:1032-9. 2011
    The product ion spectra of proline-containing peptides are commonly dominated by y(n) ions generated by cleavage at the N-terminal side of proline residues...
  94. ncbi Counting ion and water molecules in a streaming file through the open-filter structure of the K channel
    Masayuki Iwamoto
    Department of Molecular Physiology and Biophysics, University of Fukui Faculty of Medical Sciences, Eiheiji cho, Yoshida gun, Fukui 910 1193, Japan
    J Neurosci 31:12180-8. 2011
    The mechanisms underlying the selective permeation of ions through channel molecules are a fundamental issue related to understanding how neurons exert their functions...
  95. ncbi Phospholemman (FXYD1) raises the affinity of the human α1β1 isoform of Na,K-ATPase for Na ions
    Erica Cirri
    Department of Biology, University of Konstanz, 78464 Konstanz, Germany
    Biochemistry 50:3736-48. 2011
    ..The electrochromic dye RH421 which monitors binding to and release of ions from the binding sites has been applied in equilibrium titration experiments to determine ion binding affinities ..
  96. ncbi Antimicrobial action of essential oil vapours and negative air ions against Pseudomonas fluorescens
    A K Tyagi
    Applied Microbiology Laboratory, Centre for Rural Development and Technology, Indian Institute of Technology Delhi, New Delhi 110016, India
    Int J Food Microbiol 143:205-10. 2010
    ..to investigate the antibacterial activity of essential oil (in liquid as well as in vapour phase) and negative air ions (NAI) against Pseudomonas fluorescens...
  97. ncbi Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases
    Leonid Breydo
    Department of Molecular Medicine, College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd, MDC07, Tampa, Florida 33612, USA
    Metallomics 3:1163-80. 2011
    ..This review examines the effects of metal ion binding on the aggregation pathways of IDPs found in neurodegenerative diseases...
  98. ncbi Differential effect of common ligands and molecular oxygen on antimicrobial activity of silver nanoparticles versus silver ions
    Zong Ming Xiu
    Department of Civil and Environmental Engineering, Rice University, Houston, Texas 77005, USA
    Environ Sci Technol 45:9003-8. 2011
    ..Overall, these results show that the presence of O₂ or common ligands can differentially affect the toxicity of AgNPs vs Ag(+), and underscore the importance of water chemistry in the mode of action of AgNPs...
  99. ncbi Formation of diagnostic product ions from cyanobacterial cyclic peptides by the two-bond fission mechanism using ion trap liquid chromatography/multi-stage mass spectrometry
    Tsuyoshi Mayumi
    Graduate School of Environmental and Human Science, Meijo University, Tempaku, Nagoya 468 8503, Japan
    Rapid Commun Mass Spectrom 21:1025-33. 2007
    Product ions obtained by tandem mass spectrometry (MS/MS) are quite effective for the amino acid sequencing of linear peptides...
  100. pmc The use of MR-detectable reporter molecules and ions to evaluate diffusion in normal and ischemic brain
    Joseph J H Ackerman
    Department of Chemistry, Campus Box 1134, Washington University School of Medicine, St Louis, MO 63110, USA
    NMR Biomed 23:725-33. 2010
    ..from intracellular and extracellular water, a variety of endogenous and exogenous MR-detectable molecules and ions have been employed as compartment-specific reporters of water motion...
  101. ncbi Label-free fluorescent detection of ions, proteins, and small molecules using structure-switching aptamers, SYBR Gold, and exonuclease I
    Dongmei Zheng
    Department of Chemistry, Capital Normal University, Beijing, China
    Anal Chem 84:3554-60. 2012
    ..aptamers (SSAs), SYBR Gold, and exonuclease I to detect a broad range of targets including inorganic ions, proteins, and small molecules...

Research Grants77

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  2. Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer's
    Padmakar Kulkarni; Fiscal Year: 2010
    ..Plaque is comprised of aggregated fibrils of beta amyloid (A[unreadable]) collocated with transition metal ions such as Zn, Cu, and Fe, that are present in the brain...
  3. BONE MATRIX AND BONE RESORPTION
    Paul R Odgren; Fiscal Year: 2012
    ..We will investigate the C-1 domain to determine if it is regulated by diacylglycerol and requires zinc ions for its activity...
  4. Photodynamic Therapy of Localized Infections
    Michael R Hamblin; Fiscal Year: 2013
    ..blue and related penothiazinium salts could have their antimicrobial PDT effect potentiated by addition of simple ions like iodide...
  5. Ferritin: Protein/mRNA/DNA in Fe/O Regulation/Metabolism
    ELIZABETH C contact THEIL; Fiscal Year: 2010
    ..The protein nanocages self-assemble with a cavity (8 nm) for Fe/O minerals. Fe2+ ions enter and leave the ferritin protein cage through pores...
  6. Imbalances in Calcium Homeostasis: Mechanism Behind Ethanol-Related Dendritic Deg
    Cynthia A Dlugos; Fiscal Year: 2010
    ..and GRP78 It is predicted that chronic ethanol consumption will result in increases in intracellular calcium ions that will be related to ethanol-related declines in the function or expression of the SERCA 2b pump...
  7. Nanoelectrode arrays for study of the molecular mechanisms, triggers, and inhibit
    Peter J Burke; Fiscal Year: 2012
    ..When this pore opens, the critical membrane polarization of the mitochondrial inner membrane disappears and ions equilibrate between the matrix and cytosol resulting in mitochondrial swelling...
  8. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert A Knight; Fiscal Year: 2010
    ..Injury to the BBB in ischemic stroke often leads to the leakage of ions, water, amino acids, and plasma proteins into the brain and as a result in large strokes significant brain swelling ..
  9. REGULATION OF PHOSPHOLIPID SYNTHESIS
    George M Carman; Fiscal Year: 2013
    ..dephosphorylation of phosphatidate (PA) to yield diacylglycerol (DAG) and Pi, a reaction that is dependent on Mg2+ ions and is based on the DXDX(T/V) catalytic motif within a haloacid dehalogenase-like domain in the protein...
  10. Biosynthetic Protein Models of Heme-copper Oxidases and Nitric Oxide Reductases
    Yi Lu; Fiscal Year: 2013
    ..a heme-copper and a heme- iron center in the same protein framework, and the ability to introduce different metal ions into the CuB or FeB sites in the same protein is a unique opportunity that allows direct structural and functional ..
  11. Development of Bioactive Chemical Probes for Calcium-activated Chloride Channel
    Min Li; Fiscal Year: 2012
    ..They selectively conduct ions across cellular membranes and play a critical role in cellular physiology, including electrical and cellular ..
  12. Tyrosinase Model Complexes using Imidazole Ligands
    JOHN BRANNON GARY; Fiscal Year: 2013
    ..Specifically, type-3 copper sites contain 2 copper ions in close proximity and each copper is bonded to the protein backbone by three histidine nitrogens...
  13. Pathogenic Mechanisms of Pancreatitis
    Rodger A Liddle; Fiscal Year: 2013
    ..Factors that stimulate primary sensory neurons include hydrogen ions, heat, leukotrienes, arachidonic acid metabolites, bradykinin, and proteases such as trypsin, all of which may ..
  14. Cx43 phosphorylation modulates Kras mediated pancreas cancer progression
    Paul D Lampe; Fiscal Year: 2012
    ..specialized membrane domains that contain channels that allow exchange of small molecules (<1000 Da) including ions, metabolites, and second messengers (e.g., Ca2+ and IP3) between neighboring cells...
  15. Prevention and Treatment of Chlorine Gas Induced Injury to the Pulmonary System
    Sadis Matalon; Fiscal Year: 2011
    ..epithelial cells decreasing their ability to produce and secrete surfactant, actively transport sodium (Na+) ions and maintain a tight, semi-permeable barrier...
  16. Structure and function of chloride channels and transporters
    Alessio Accardi; Fiscal Year: 2013
    ..All family members catalyze movement of Cl- ions across cellular membranes, but can do so via either of two thermodynamically opposing mechanisms: the CLC channels ..
  17. INTRACELLULAR CALCIUM IN HAIR CELLS
    Robert Fettiplace; Fiscal Year: 2013
    ..mechanisms by documenting the mechanical and electrical properties of auditory hair cells and their modulation by calcium ions. We hypothesize that calcium overloading leading to mitochondrial dysfunction is a major route to cell damage.
  18. Role of spectrin/ankyrin-G complex in myocyte signaling and cardiac excitability
    Peter J Mohler; Fiscal Year: 2013
    Project Summary Ion channels and transporters control the movement of charged ions across cell membranes...
  19. Molecular mechanisms of bacterial homologs of neurotransmitter:sodium symporters
    Jonathan A Javitch; Fiscal Year: 2013
    ..Neurotransmitter:sodium symporters (NSS) couple the accumulation of substrate to the movement of sodium ions down their concentration gradient across the plasma membrane, and as such constitute key elements in cellular ..
  20. VOLTAGE SENSITIVE SODIUM CHANNELS IN BRAIN
    William A Catterall; Fiscal Year: 2013
    ..and discovered that mutations in the voltage sensor module cause gating pore current-a voltage-gated leak of ions through the mutant voltage sensor into the cell...
  21. 2011 Mechanisms of Membrane Transport Gordon Research Conference
    Nancy Carrasco; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: By regulating the movement of water soluble substrates such as ions and nutrients, transporters and channels play essential roles in both the kidney and digestive systems...
  22. Triple Quadrupole/Linear Ion Trap LC-MS/MS for LPI
    Jan Frederik Stevens; Fiscal Year: 2010
    ..ion guide which operates at higher pressure to increase ion transmission by collisional cooling and focusing of ions. A major improvement is the new Linear Accelerator Trap which shows superior extraction efficiency and resolving ..
  23. Transcriptional Networks Regulating Luminal Environment in the Epididymis
    Ann Harris; Fiscal Year: 2013
    ..part of the excretory duct system of the male reproductive tract and is a complex organ that secretes and absorbs ions, water and inorganic solutes. Critically, it provides the correct luminal environment for normal sperm maturation...
  24. ClC-3 ion transport modulates NADPH oxidase-dependent PMN priming by endotoxin
    Jessica G Moreland; Fiscal Year: 2012
    ..will define the localization and kinetics of oxidant generation by priming stimuli, and explore the relevant ions that might participate in this process...
  25. Predictive Toxicological Paradigms to Establish Inhalation Toxicology Models
    ANDRE ELIAS NEL; Fiscal Year: 2010
    ..cytotoxic injury will be explicable by nanoparticle properties that lead to oxidant injury, shedding of toxic metal ions, and ability to trigger mitochondrial injury...
  26. Selectivity and Permeation in the Human Voltage-gated Proton Channel, hHv1
    Susan M E Smith; Fiscal Year: 2013
    ..to how the proton channel does its job, which is moving protons across cell membranes, while excluding all other ions. We recently discovered the location of the "selectivity filter" of the proton channel, but the mechanism of its ..
  27. VOLUME REGULATION IN NORMAL AND CATARACTOUS LENSES
    Richard T Mathias; Fiscal Year: 2013
    ..The circulation depends on fiber cell gap junctions to conduct intracellular fluxes of ions and perhaps fluid, which flow from the center to surface of the lens...
  28. The role of two-pore channels in integrative calcium signaling
    Michael X Zhu; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Calcium ions are very important for cell signaling...
  29. Tumor -Targeting Chemotherapeutic Agents
    Iwao Ojima; Fiscal Year: 2013
    ..For that purpose, drug conjugates with ultra-short SWNTs encapsulating gadolinium ions as well as [11C]-labeled warheads will be synthesized...
  30. Structure and Specificity in Metal Ion Homeostasis
    Amy C Rosenzweig; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acquisition and management of metal ions is a critical part of metabolism for all forms of life because metalloproteins comprise close to one third of all proteins and almost half of all enzymes...
  31. Investigation of Zinc Neurochemistry by Optical Sensing and MRI
    Stephen J Lippard; Fiscal Year: 2013
    ..modules typically comprise multidentate ligands with variable Zn2+ affinity, selectivity for Zn2+ over competing ions in neuronal tissue, and fast, reversible coordination to monitor biological changes on the ms time scale...
  32. INTRACOCHLEAR ELECTROCHEMICAL GRADIENTS
    Alexander A Spector; Fiscal Year: 2012
    ..Prestin belongs to a family of membrane proteins that facilitate the movement of anions (negatively charged ions such as chloride) through the cell membrane...
  33. Physiology and Biophysics of Cardiac Slo2.1 Channels
    Alexey V Zaitsev; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Ion channels are membrane-bound proteins that selectively conduct specific ions in and out of cells...
  34. CONTROL OF BACTERIAL TOXINS BY VIRUSES AND PLASMIDS
    Randall K Holmes; Fiscal Year: 2013
    ..and we developed lead compounds that promote activation of DbcR or IdeR at lower concentrations of ferrous ions than are needed to activate DtxR or IdeR by itself...
  35. 2010 and 2012 Membrane Transport Proteins
    Robert H Edwards; Fiscal Year: 2012
    All living organisms depend on the transport of inorganic ions and organic solutes across cellular membranes...
  36. Investigating SloR virulence gene metalloregulation in S. mutans.
    Grace A Spatafora; Fiscal Year: 2013
    ..mutans is directly related to the availability and transport of essential metal ions in the plaque environment, particularly iron and manganese, metal ion uptake mechanisms represent attractive ..
  37. Blood Coagulation Protein - Metal Ion - Lipid Interactions
    Francis J Castellino; Fiscal Year: 2013
    ..in vivo, with specific attention paid to interactions of the g-carboxyglutamic acid (Gla) domains (GD) with metal ions, membranes, and receptors...
  38. Alcohol increases tight junction permeability &disrupts translocation of ZO-1
    Samantha Simet; Fiscal Year: 2012
    ..in airway epithelium where they regulate cell polarity and act to selectively regulate the passage of water, ions, neutral molecules and inflammatory cells through the paracellular pathway...
  39. Toxic Metal Complexation by de Novo Designed Peptides
    Vincent L Pecoraro; Fiscal Year: 2013
    ..toxicity, developing ways to minimize human exposure and to provide therapeutic regimens for the removal of toxic ions. Our goals are (1) to develop peptide systems that provide a foundation for understanding metal binding by ..
  40. Investigating SloR virulence gene metalloregulation in S. mutans.
    Grace Spatafora; Fiscal Year: 2009
    ..mutans is directly related to the availability and transport of essential metal ions in the plaque environment, particularly iron and manganese, metal ion uptake mechanisms represent attractive ..
  41. Molecular mechanisms of electrical synapse formation in vivo
    Adam C Miller; Fiscal Year: 2013
    ..Electrical synapses are sites of direct communication between neurons that allow the passage of ions and small molecules...
  42. Endogenous Gas Molecules As Transcription Factors
    Leo E Otterbein; Fiscal Year: 2012
    ..Our central hypothesis is that gaseous CO interacts directly with DNA via metal ions in complex with polymerases and topoisomersases present on DNA...
  43. GENETIC STUDIES OF ODDD
    Ethylin Wang Jabs; Fiscal Year: 2010
    ..These channels confer distinct physiologic properties by providing an intercellular passage for ions and small molecules...
  44. Function of metal transporter ZIP14 as regulated by proinflammatory stimuli
    Robert J Cousins; Fiscal Year: 2013
    ..Cells use 24 different zinc transporter proteins derived from two gene families to direct zinc ions to intracellular sites...
  45. 3D Structure and Function of CRAC Channels
    STEPHEN BARSTOW LONG; Fiscal Year: 2013
    ..Aside from being an integral membrane protein, Orai has no significant amino acid sequence homology to other known ions channels...
  46. Designing an Integrated Nanoscale System for Ion Channel Structure-Function Study
    Ratneshwar Lal; Fiscal Year: 2013
    ..Their 3D structure and their permeability to ions and signaling molecules, in response to drug addiction-inducing stimuli will be examined...
  47. Investigating the role of Bacillithiol in metal ion homeostasis and the reactive
    Pete Chandrangsu; Fiscal Year: 2013
    ..Aim 2 will center on the contribution of BSH in cellular zinc homeostasis. Zinc ions are critical for essential cellular functions, serving structural roles in proteins and as cofactors for essential ..
  48. A model of kidney stone disease using D. melanogaster
    Marshall Stoller; Fiscal Year: 2013
    ..melanogaster), the Malpighian tubule is the functional equivalent of the human convoluted tubule and transports ions and other solutes from the fly circulatory system into the excretory system...
  49. smFRET Investigation of Gating in a Neurotransmitter Transporter Homolog
    RACHEL ANN KOLSTER; Fiscal Year: 2013
    ..NSS are regulated by a complex interplay of substrates, ions, post-translational modifications and interacting proteins...
  50. Calcium Signaling in Pancreatic Beta Cell Endoplasmic Reticulum
    MICHAEL WILLIAM ROE; Fiscal Year: 2010
    ..overall objectives of this proposal are to better understand the regulation of insulin secretion by free calcium ions (Ca2+) and the role of abnormal Ca2+ signaling in the pathophysiology of Type 2 diabetes mellitus (T2DM)...
  51. Quantitative Mass Spectrometry Assays to Detect Multiple Myeloma and Assess Relap
    JOHN MATTHEW KOOMEN; Fiscal Year: 2010
    ..g. argon);then, selective fragment ions are filtered out for detection...
  52. Epigenetic Regulation of Kir4.1 and GLT1 in Pathophysiology
    Michelle L Olsen; Fiscal Year: 2013
    ..the regulation of two essential functions of astrocytes following injury: the ability to buffer extracellular K+ ions and to regulate extracellular glutamate concentrations...
  53. STRUCTURAL STUDIES ON PROKARYOTIC POTASSIUM CHANNELS
    Adrian Gross; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Ion channels are membrane proteins that allow ions to pass from one side of the cell membrane to the other...
  54. Proteomic Evaluation of the Blood-Brain Barrier Receptor-Mediated Transportome
    Eric V Shusta; Fiscal Year: 2013
    ..vascular beds because it constitutes a physical and metabolic barrier that tightly regulates brain uptake of ions, small molecules, proteins, and circulating cells...
  55. Extracellular Zinc Buffering and A-beta Oligomerization
    GUIDO FAAS; Fiscal Year: 2012
    ..One of the theories is the "metal hypothesis of AD" which posits that extracellular metal ions, especially synaptically excreted Zn2+, instigate the Ab oligomerization and aggregation leading to the formation ..
  56. Foundations of Pretargeted Radioimmunotherapy
    KARL D WITTRUP; Fiscal Year: 2013
    ..project period, bispecific antibodies (bsAbs) were engineered with picomolar affinity both to chelated metal ions and to tumor antigens (specifically, the colorectal carcinoma antigens A33 or CEA)...
  57. Properties of Clca Channels in Vascular Myocytes
    Normand Leblanc; Fiscal Year: 2009
    ..In smooth muscle cells, chloride ions (Cl-) are not passively distributed across the cell membrane...
  58. Molecular mechanisms of potassium channel permeation and gating
    Crina M Nimigean; Fiscal Year: 2013
    ..KcsA selectivity using a multidisciplinary three-pronged approach: 1) electrophysiology of KcsA block by impermeant ions using analysis of single- channel current recordings, 2) X-ray crystallography of the blocked KcsA channels, and 3) ..
  59. Individual Predoctoral Dental Scientist Fellowship
    MELISSA ANNE TALBERT; Fiscal Year: 2011
    ..This degradative process releases metal ions, which stimulate fibrous tissue formation, leading to impairment of osseointegration and implant failure...
  60. Enteric Virus Calcium Channel Inhibitors
    Joseph M Hyser; Fiscal Year: 2013
    ..Chief among the biologically relevant ions is calcium, a ubiquitous secondary messenger that is involved in many signaling pathways...
  61. Voltage-Gating in Bacterial Ion Channels
    Ana M Correa; Fiscal Year: 2010
    ..proteins found in the membranes of practically all cells and that through opening and closing (gating) events let ions flow through between the internal and external milieu of the cells acting as very fast signaling entities...
  62. Fluorescent Copper Probes for Intracellular Imaging
    Christoph J Fahrni; Fiscal Year: 2013
    ..Because free copper ions catalyze the production of highly reactive hydroxyl radicals, which can damage lipids, proteins, DNA, and other ..
  63. Sub-Wavelength Imaging of Intracellular Metal Ions
    Joseph R Lakowicz; Fiscal Year: 2010
    ..the Challenge Area (06) Enabling Technologies and Specific Challenge Topic 06-GM-106;subcellular imaging of metal ions. Fluorescence microscopy is one of the most widely used methods in the biological sciences...
  64. METALS/NUCLEOSIDE HYDROPEROXIDE MEDIATED GENETIC DAMAGE
    Krystyna Frenkel; Fiscal Year: 1992
    ..activities of some of the hydroperoxides were significantly increased in the presence of certain transitional metal ions. These metal ions catalyze hydrolysis of hydroperoxides with the formation of reactive oxygen species which ..
  65. Monovalent metal ion binding sites in nucleic acids
    SCOTT STROBEL; Fiscal Year: 2004
    ..Metal ions act as essential cofactors in the folding of RNAs...
  66. Structural Basis for Bridged Bimetallic Enzyme Catalysis
    Dagmar Ringe; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): More than half of all proteins contain metal ions. A large percentage of those contain two metal ions (usually first-row transition metals or magnesium) connected by a bridging ligand (usually a ..
  67. FUNCTIONAL ANALYSIS OF A LEAD/CADMIUM/ZINC ATPASE
    Bharati Mitra; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): P1B-type ATPases transport soft metal ions across membranes...
  68. Catalytic DNA Biosensor for Toxic Metal Ions
    Yi Lu; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Cost-effective catalytic DNA biosensors for heavy metal ions such as lead(II), uranium(VI), mercury(II), and cadmium(II) will be developed...
  69. Chemistry of Reactive Intermediates Generated from Benzothiazole Derived Drug Can
    Michael Novak; Fiscal Year: 2009
    ..conversion, by a series of metabolic and chemical reactions, into selective, electrophilic nitrenium or oxenium ions. This project will test of the ability of putative metabolites of the two lead benzothiazoles to generate reactive ..
  70. NOVEL CONCEPT FOR DEGRADATION OF ABSORBABLE POLYMERS
    Chih Chang Chu; Fiscal Year: 1990
    ..It has been known that alkaline hydrolysis of SAS is due to the initial attack of negative-charged [OH-] ions in the physiological buffer to the surface of SAS...
  71. Computational Suite for RNA-Targeted Drug Design
    Erin Duffy; Fiscal Year: 2005
    ..We aim to extend and validate computational methods and protocols for treating accurately the interactions among RNA, ions and ligands...
  72. NMR STUDIES OF CYTOSOLIC METAL IONS AND OXIDATIVE STRESS
    Raj Gupta; Fiscal Year: 2006
    ..DESCRIPTION (provided by applicant): Our long-range goal is to elucidate the role of intracellular mineral ions (Na+, K+, free Mg2+ & free Ca2+) and oxidative stress in the pathophysiology of essential hypertension and type ..
  73. Catalytic DNA Biosensor for Toxic Metal Ions
    Yi Lu; Fiscal Year: 2005
    ..DNA biosensors for on-site, real-time, and cost-effective detection and quantification of multiple heavy metal ions, such as mercury, cadmium and lead, simultaneously will be explored...
  74. ELECTRON MONOCHROMATOR TIME-OF-FIGHT MASS SPECTROMETER
    Max Deinzer; Fiscal Year: 2002
    The interaction of low-energy electrons with electrophilic molecules in the production of negative ions is an important chemical process...
  75. GAS PHASE ANALYTICAL CHEMISTRY OF PEPTIDE IONS
    Simon Gaskell; Fiscal Year: 1992
    ..characterization of peptides is currently limited by imperfect understanding of the gas-phase chemistry of peptide ions. Our recent tandem MS analyses of tryptic peptides derived from human a B-100, together with synthetic analogues, ..
  76. EFFECT OF HEAVY METAL IONS--EUKARYOTIC PROTEIN SYNTHESIS
    Robert Matts; Fiscal Year: 1991
    ..play in the control of cellular proliferation, differentiation and aging; and to determine how heavy metal ions, through their effects on protein synthesis, may adversely affect these processes...
  77. Crystallography without crystals: Atomic structure determination of laser oriente
    Wei Kong; Fiscal Year: 2010
    ..In this project, protein ions generated from an electrospray ionization source will be embedded in a pulsed stream of superfluid helium droplets...