ions

Summary

Summary: An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS.

Top Publications

  1. pmc Tuning transport properties of nanofluidic devices with local charge inversion
    Yan He
    Department of Physics and Astronomy, University of California, Irvine, Irvine, California, USA
    J Am Chem Soc 131:5194-202. 2009
  2. ncbi Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents
    Philip L Ross
    Applied Biosystems, Framingham, MA 01701, USA
    Mol Cell Proteomics 3:1154-69. 2004
  3. doi Metal ions in biological catalysis: from enzyme databases to general principles
    Claudia Andreini
    Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019, Sesto Fiorentino, Italy
    J Biol Inorg Chem 13:1205-18. 2008
  4. pmc Relationships between growth, growth response to nutrient supply, and ion content using a recombinant inbred line population in Arabidopsis
    Aina E Prinzenberg
    Department of Plant Breeding and Genetics, Max Planck Institute for Plant Breeding Research, Cologne, Germany
    Plant Physiol 154:1361-71. 2010
  5. ncbi Alternate dissociation pathways identified in charge-reduced protein complex ions
    Kevin Pagel
    University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW, UK
    Anal Chem 82:5363-72. 2010
  6. pmc The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions
    Yuanyuan Y Wang
    Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 2520, USA
    J Biol Chem 283:32691-703. 2008
  7. pmc Substoichiometric levels of Cu2+ ions accelerate the kinetics of fiber formation and promote cell toxicity of amyloid-{beta} from Alzheimer disease
    Claire J Sarell
    School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, United Kingdom
    J Biol Chem 285:41533-40. 2010
  8. ncbi Repair kinetics of DNA-DSB induced by X-rays or carbon ions under oxic and hypoxic conditions
    Ryoichi Hirayama
    Graduate School of Science and Technology, Chiba University, Yayoi cho 1 33, Inage Ku, Chiba 163 8522, Japan
    J Radiat Res 46:325-32. 2005
  9. ncbi Mass spectrometric identification of proteins from silver-stained polyacrylamide gel: a method for the removal of silver ions to enhance sensitivity
    F Gharahdaghi
    The Rockefeller University Protein DNA Technology Center, New York, NY 10021, USA
    Electrophoresis 20:601-5. 1999
  10. doi Elemental composition determination based on MS(n)
    Miguel Rojas-Chertó
    Netherlands Metabolomics Centre, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Bioinformatics 27:2376-83. 2011

Detail Information

Publications282 found, 100 shown here

  1. pmc Tuning transport properties of nanofluidic devices with local charge inversion
    Yan He
    Department of Physics and Astronomy, University of California, Irvine, Irvine, California, USA
    J Am Chem Soc 131:5194-202. 2009
    Nanotubes can selectively conduct ions across membranes to make ionic devices with transport characteristics similar to biological ion channels and semiconductor electron devices...
  2. ncbi Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents
    Philip L Ross
    Applied Biosystems, Framingham, MA 01701, USA
    Mol Cell Proteomics 3:1154-69. 2004
    ..The derivatized peptides are indistinguishable in MS, but exhibit intense low-mass MS/MS signature ions that support quantitation...
  3. doi Metal ions in biological catalysis: from enzyme databases to general principles
    Claudia Andreini
    Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019, Sesto Fiorentino, Italy
    J Biol Inorg Chem 13:1205-18. 2008
    We analysed the roles and distribution of metal ions in enzymatic catalysis using available public databases and our new resource Metal-MACiE (http://www.ebi.ac.uk/thornton-srv/databases/Metal_MACiE/home.html)...
  4. pmc Relationships between growth, growth response to nutrient supply, and ion content using a recombinant inbred line population in Arabidopsis
    Aina E Prinzenberg
    Department of Plant Breeding and Genetics, Max Planck Institute for Plant Breeding Research, Cologne, Germany
    Plant Physiol 154:1361-71. 2010
    ..These lines retained over 20% more rosette weight in reduced potassium supply, accompanied by an increase in potassium content in their leaves...
  5. ncbi Alternate dissociation pathways identified in charge-reduced protein complex ions
    Kevin Pagel
    University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW, UK
    Anal Chem 82:5363-72. 2010
    ..Taken together, the results presented highlight the potential of charge state modulation as a method for directing the course of gas-phase dissociation and unfolding of protein complexes...
  6. pmc The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions
    Yuanyuan Y Wang
    Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 2520, USA
    J Biol Chem 283:32691-703. 2008
    ..In conclusion, we have further clarified the mechanisms of potentiation and inactivation of TRPA1 using the D918A pore mutant, an important tool for investigating the contribution of Ca(2+) influx through TRPA1 to nociceptive signaling...
  7. pmc Substoichiometric levels of Cu2+ ions accelerate the kinetics of fiber formation and promote cell toxicity of amyloid-{beta} from Alzheimer disease
    Claire J Sarell
    School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, United Kingdom
    J Biol Chem 285:41533-40. 2010
    A role for Cu(2+) ions in Alzheimer disease is often disputed, as it is believed that Cu(2+) ions only promote nontoxic amorphous aggregates of amyloid-β (Aβ)...
  8. ncbi Repair kinetics of DNA-DSB induced by X-rays or carbon ions under oxic and hypoxic conditions
    Ryoichi Hirayama
    Graduate School of Science and Technology, Chiba University, Yayoi cho 1 33, Inage Ku, Chiba 163 8522, Japan
    J Radiat Res 46:325-32. 2005
    ..CHO cells were exposed to 200 kVp X-rays or 80 keV/microm carbon ions under oxic and hypoxic conditions. DNA-DSB in the cells were analyzed by a static-field gel electrophoresis (SFGE)...
  9. ncbi Mass spectrometric identification of proteins from silver-stained polyacrylamide gel: a method for the removal of silver ions to enhance sensitivity
    F Gharahdaghi
    The Rockefeller University Protein DNA Technology Center, New York, NY 10021, USA
    Electrophoresis 20:601-5. 1999
    ....
  10. doi Elemental composition determination based on MS(n)
    Miguel Rojas-Chertó
    Netherlands Metabolomics Centre, Leiden Amsterdam Center for Drug Research, Leiden, The Netherlands
    Bioinformatics 27:2376-83. 2011
    ..High-resolution mass spectrometry, which provides the exact mass, together with common constraint rules, for rejecting false proposed elemental compositions, cannot always provide one unique elemental composition solution...
  11. ncbi Comparison of efficacy and toxicity of short-course carbon ion radiotherapy for hepatocellular carcinoma depending on their proximity to the porta hepatis
    Hiroshi Imada
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Radiother Oncol 96:231-5. 2010
    ..To compare the efficacy and toxicity of short-course carbon ion radiotherapy (C-ion RT) for patients with hepatocellular carcinoma (HCC) in terms of tumor location: adjacent to the porta hepatis or not...
  12. doi Complexation of metal ions with TRAP (1,4,7-triazacyclononane phosphinic acid) ligands and 1,4,7-triazacyclononane-1,4,7-triacetic acid: phosphinate-containing ligands as unique chelators for trivalent gallium
    Jakub Simeček
    Department of Inorganic Chemistry, Univerzita Karlova Charles University, Hlavova 2030, 12843 Prague 2, Czech Republic
    Inorg Chem 51:577-90. 2012
    ..constants of ligands and stability constants of their complexes with Ga(3+), selected divalent metal, and Ln(3+) ions were determined by potentiometry...
  13. pmc Dynamics of pyrophosphate ion release and its coupled trigger loop motion from closed to open state in RNA polymerase II
    Lin Tai Da
    Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
    J Am Chem Soc 134:2399-406. 2012
    ..Our simulations provide predictions to guide future experimental tests...
  14. pmc The competition of charge remote and charge directed fragmentation mechanisms in quaternary ammonium salt derivatized peptides--an isotopic exchange study
    Marzena Cydzik
    Faculty of Chemistry, University of Wrocław, F Joliot Curie 14, 50 383 Wrocław, Poland
    J Am Soc Mass Spectrom 22:2103-7. 2011
    ..The isotopic labeling allows differentiation of fragments formed according to ChR and ChD mechanisms...
  15. pmc Treatment of patients with atypical meningiomas Simpson grade 4 and 5 with a carbon ion boost in combination with postoperative photon radiotherapy: the MARCIE trial
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 10:615. 2010
    ..Carbon ions offer physical and biological characteristics...
  16. ncbi Evidence for macromolecular protein rings in the absence of bulk water
    Brandon T Ruotolo
    Department of Chemistry, Lensfield Road, University of Cambridge, Cambridge CB2 1EW, UK
    Science 310:1658-61. 2005
    ....
  17. doi Effect of metal ions (Li+, Na+, K+, Mg2+, Ca2+, Ni2+, Cu2+ and Zn2+) and water coordination on the structure and properties of L-histidine and zwitterionic L-histidine
    Milan Remko
    Department of Pharmaceutical Chemistry, Comenius University, Odbojarov 10, 832 32, Bratislava, Slovakia
    Amino Acids 39:1309-19. 2010
    Interactions between metal ions and amino acids are common both in solution and in the gas phase. The effect of metal ions and water on the structure of L-histidine is examined...
  18. ncbi Ion suppression in mass spectrometry
    Thomas M Annesley
    Department of Pathology, University of Michigan Medical Center, Ann Arbor, MI 48109 0054, USA
    Clin Chem 49:1041-4. 2003
    ..It provides specificity because of its ability to monitor selected mass ions, sensitivity because of the enhanced signal-to-noise ratio, and speed because it can help avoid the need for ..
  19. pmc Substrate binding and formation of an occluded state in the leucine transporter
    Leyla Celik
    Department of Biochemistry, Center for Biophysics and Computational Biology, and Beckman Institute, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    Biophys J 94:1600-12. 2008
    ..simulations have been performed on different combinations of LeuT, bound substrate, and bound structural Na(+) ions to describe molecular events involved in substrate binding and in the formation of the occluded state and to ..
  20. ncbi Measurement of selected ions related to oxidative stress and energy metabolism in Saudi autistic children
    Afaf El-Ansary
    Biochemistry Department, Science College, King Saud University, PO Box 22452, Zip code 11495, Riyadh, Saudi Arabia
    Clin Biochem 43:63-70. 2010
    ..This study aims to clarify the role of selected ions related to energy metabolism as a consequence of oxidative stress in the deterioration accompanied autism.
  21. ncbi Role of halide ions and temperature on the morphology of biologically synthesized gold nanotriangles
    Akhilesh Rai
    Nanoscience Group, Materials Chemistry Division, National Chemical Laboratory, Pune 411 008, India
    Langmuir 22:736-41. 2006
    In this paper, we demonstrate the effect of halide ions on the formation of biogenically prepared gold nanotriangles using the leaf extract of lemongrass (Cymbopogon flexuosus) plant...
  22. doi Chemiluminescent and chemiluminescence resonance energy transfer (CRET) detection of DNA, metal ions, and aptamer-substrate complexes using hemin/G-quadruplexes and CdSe/ZnS quantum dots
    Ronit Freeman
    Institute of Chemistry, Center of Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Am Chem Soc 133:11597-604. 2011
    ..the horseradish peroxidase (HRP)-mimicking DNAzyme and aptamer domains against ATP or sequences recognizing Hg(2+) ions self-assemble, in the presence of ATP or Hg(2+), into the active hemin-G-quadruplex DNAzyme structure...
  23. ncbi Determination of ion structures in structurally related compounds using precursor ion fingerprinting
    Michelle T Sheldon
    Commonwealth of Virginia, Department of General Services, Division of Consolidated Laboratory Services, Richmond, Virginia 23219, USA
    J Am Soc Mass Spectrom 20:370-6. 2009
    ..PIF is a new approach for interpreting and library-searching ESI mass spectra predicated on the precursor ions of structurally-related compounds and their matching product ion spectra...
  24. ncbi Heidelberg Ion Therapy Center (HIT): Initial clinical experience in the first 80 patients
    Stephanie E Combs
    University Hospital of Heidelberg, Department of Radiation Oncology, 69120 Heidelberg, Germany
    Acta Oncol 49:1132-40. 2010
    ..In this report we present the first 80 patients treated with proton and carbon ion radiotherapy and describe patient selection, treatment planning and daily treatment for different indications...
  25. doi Bridging like-charged macroions through long divalent rodlike ions
    Sylvio May
    Department of Physics, North Dakota State University, Fargo, ND 58105 5566, USA
    J Phys Chem B 112:1685-92. 2008
    ..if the spatially extended structure (which reflects the presence of intramolecular correlations) of the mobile ions in the electrolyte is accounted for...
  26. pmc RNA folding: thermodynamic and molecular descriptions of the roles of ions
    David E Draper
    Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Biophys J 95:5489-95. 2008
    The stability of a compact RNA tertiary structure is exquisitely sensitive to the concentrations and types of ions that are present...
  27. doi Ion mobility mass spectrometry of proteins and protein assemblies
    Charlotte Uetrecht
    Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Chem Soc Rev 39:1633-55. 2010
    ..to mass spectrometry providing a new dimension in the analysis of biomolecules, with ion mobility separating ions according to differences in size and shape...
  28. pmc Nanoscale live-cell imaging using hopping probe ion conductance microscopy
    Pavel Novak
    Imperial College London, UK
    Nat Methods 6:279-81. 2009
    ..The technique allowed examination of nanoscale phenomena on the surface of live cells under physiological conditions...
  29. doi Copper(II) binding to amyloid-beta fibrils of Alzheimer's disease reveals a picomolar affinity: stoichiometry and coordination geometry are independent of Abeta oligomeric form
    Claire J Sarell
    School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, UK
    Biochemistry 48:4388-402. 2009
    Cu(2+) ions are found concentrated within senile plaques of Alzheimer's disease patients directly bound to amyloid-beta peptide (Abeta) and are linked to the neurotoxicity and self-association of Abeta...
  30. ncbi The implications of proteolytic background for shotgun proteomics
    Paola Picotti
    Institute of Molecular Systems Biology, ETH Zurich, CH 8093, Zurich, Switzerland
    Mol Cell Proteomics 6:1589-98. 2007
    ....
  31. ncbi Induction of protein oxidation by cobalt and chromium ions in human U937 macrophages
    Alain Petit
    Division of Orthopaedic Surgery, Lady Davis Institute for Medical Research, McGill University, The SMBD Jewish General Hospital, 3755 Ch Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    Biomaterials 26:4416-22. 2005
    Metal particles and ions from hip prostheses have the potential to induce the production of reactive oxygen species (ROS), making them prime suspects for disturbing the cellular balance of oxidants/antioxidants (redox state of the cell)...
  32. pmc Combined treatment of malignant salivary gland tumours with intensity-modulated radiation therapy (IMRT) and carbon ions: COSMIC
    Alexandra D Jensen
    Dept, of Radiation Oncology, INF 400, 69120 Heidelberg, Germany
    BMC Cancer 10:546. 2010
    ....
  33. pmc Randomised phase I/II study to evaluate carbon ion radiotherapy versus fractionated stereotactic radiotherapy in patients with recurrent or progressive gliomas: the CINDERELLA trial
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 10:533. 2010
    ..Carbon ions offer physical and biological characteristics...
  34. pmc Electrochemical microsensors for the detection of cadmium(II) and lead(II) ions in plants
    Olga Krystofova
    Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Zemedelska 1, CZ 613 00 Brno, Czech Republic
    Sensors (Basel) 10:5308-28. 2010
    ..and a homemade micropotentiostat] for easy-to-use and sensitive determination of cadmium(II) and lead(II) ions. The lowest detection limits (hundreds of pM) for both metals was achieved by using of the standard potentiostat, ..
  35. ncbi Exploring the precursor ion exclusion feature of liquid chromatography-electrospray ionization quadrupole time-of-flight mass spectrometry for improving protein identification in shotgun proteome analysis
    Nan Wang
    Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada
    Anal Chem 80:4696-710. 2008
    ..This strategy is based on running replicates of the sample where the precursor ions detected in the initial run(s) are excluded for MS/MS in the subsequent run...
  36. doi Towards understanding the tandem mass spectra of protonated oligopeptides. 2: The proline effect in collision-induced dissociation of protonated Ala-Ala-Xxx-Pro-Ala (Xxx = Ala, Ser, Leu, Val, Phe, and Trp)
    Christian Bleiholder
    Department of Molecular Biophysics, German Cancer Research Center DKFZ, Heidelberg, Germany
    J Am Soc Mass Spectrom 22:1032-9. 2011
    The product ion spectra of proline-containing peptides are commonly dominated by y(n) ions generated by cleavage at the N-terminal side of proline residues...
  37. pmc Determination of the Na(+)/glucose cotransporter (SGLT1) turnover rate using the ion-trap technique
    Jean Philippe Longpré
    Groupe d étude des protéines membranaires GÉPROM, Departement de Physique, Universite de Montreal, Montreal, Quebec, Canada
    Biophys J 100:52-9. 2011
    The Na(+)/glucose cotransporter (SGLT1) is a membrane protein that couples the transport of two Na(+) ions and one glucose molecule using the so-called alternating access mechanism...
  38. doi Generalized stern models of the electric double layer considering the spatial variation of permittvity and finite size of ions in saturation regime
    Ekaterina Gongadze
    Institute of General Electrical Engineering, University of Rostock, Albert Einstein Straße 2, 18051, Rostock, Germany
    Cell Mol Biol Lett 16:576-94. 2011
    ..introduce two Langevin models for spatial variation of the relative permittivity for point-like and finite sized ions. We attempt to uncover the subtle interplay between water ordering and finite sized ions and their impact on the ..
  39. pmc LC-MSsim--a simulation software for liquid chromatography mass spectrometry data
    Ole Schulz-Trieglaff
    International Max Planck Research School for Computational Biology and Scientific Computing, Berlin, Germany
    BMC Bioinformatics 9:423. 2008
    ..So far, curated benchmark data exists only for peptide identification algorithms but no data that represents a ground truth for the evaluation of feature detection, alignment and filtering algorithms...
  40. doi Graphene oxide papers modified by divalent ions-enhancing mechanical properties via chemical cross-linking
    Sungjin Park
    Department of Mechanical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208 3111, USA
    ACS Nano 2:572-8. 2008
    ..of the chemical interactions between the functional groups of the graphene oxide sheets and the divalent metals ions. While oxygen functional groups on the basal planes of the sheets and the carboxylate groups on the edges can both ..
  41. pmc Inorganic phosphate and sodium ions are cogerminants for spores of Clostridium perfringens type A food poisoning-related isolates
    Daniel Paredes-Sabja
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon 97331, USA
    Appl Environ Microbiol 75:6299-305. 2009
    ..Previously, we showed that only spores of FP isolates were able to germinate with K(+) ions. We now found that the spores of the majority of FP isolates, but none of the NFB isolates, germinated with the ..
  42. doi Electrical detection of metal ions using field-effect transistors based on micropatterned reduced graphene oxide films
    Herry Gunadi Sudibya
    School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, Singapore
    ACS Nano 5:1990-4. 2011
    ..Such a nanoelectronic sensor is able to detect various metal ions in real-time with high sensitivity.
  43. ncbi Influence of size on apparent scrambling of sequence during CID of b-type ions
    Samuel Molesworth
    Department of Chemistry, Wichita State University, Wichita, Kansas 67260 0051, USA
    J Am Soc Mass Spectrom 20:2174-81. 2009
    ..the influence of peptide size on the apparent loss of sequence during collision-induced dissociation (CID) of b ions using a group of peptides containing from between 4 and 10 residues...
  44. pmc Dimensions and ion selectivity of recombinant AMPA and kainate receptor channels and their dependence on Q/R site residues
    N Burnashev
    Max Planck Institut fur medizinische Forschung, Abteilung Zellphysiologie, Heidelberg, Germany
    J Physiol 496:165-73. 1996
    ..Therefore, the differences in the anion versus cation selectivity, in Ca2+ permeability and in channel conductance are likely to be determined by the difference in charge density of the channel...
  45. doi Sub-toxic effects of CuO nanoparticles on bacteria: kinetics, role of Cu ions and possible mechanisms of action
    Olesja Bondarenko
    Laboratory of Molecular Genetics, National Institute of Chemical Physics and Biophysics, Tallinn, Estonia
    Environ Pollut 169:81-9. 2012
    ..specifically to (i) reactive oxygen species (ROS), (ii) single-stranded DNA breaks and (iii) bioavailable Cu ions. Using these sensors we showed that nano-CuO induces the formation of superoxide anions, hydrogen peroxide and ..
  46. doi Phosphorylated serine and threonine residues promote site-specific fragmentation of singly charged, arginine-containing peptide ions
    Peter Max Gehrig
    Functional Genomics Center Zurich, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Rapid Commun Mass Spectrom 23:1435-45. 2009
    In order to investigate gas-phase fragmentation reactions of phosphorylated peptide ions, matrix-assisted laser desorption/ionization (MALDI) and electrospray ionization (ESI) tandem mass (MS/MS) spectra were recorded from synthetic ..
  47. doi Excluded volume effect and orientational ordering near charged surface in solution of ions and Langevin dipoles
    Ales Iglic
    Laboratory of Biophysics, Faculty of Electrical Engineering, University of Ljubljana, Trzaska 25, SI 1000 Ljubljana, Slovenia
    Bioelectrochemistry 79:223-7. 2010
    The influence of a finite volume of ions and orientational ordering of water Langevin dipoles on the dielectric permittivity profile in the vicinity of charged surface is studied theoretically via a numerical solution of the modified ..
  48. pmc The use of MR-detectable reporter molecules and ions to evaluate diffusion in normal and ischemic brain
    Joseph J H Ackerman
    Department of Chemistry, Campus Box 1134, Washington University School of Medicine, St Louis, MO 63110, USA
    NMR Biomed 23:725-33. 2010
    ..from intracellular and extracellular water, a variety of endogenous and exogenous MR-detectable molecules and ions have been employed as compartment-specific reporters of water motion...
  49. ncbi Formation of diagnostic product ions from cyanobacterial cyclic peptides by the two-bond fission mechanism using ion trap liquid chromatography/multi-stage mass spectrometry
    Tsuyoshi Mayumi
    Graduate School of Environmental and Human Science, Meijo University, Tempaku, Nagoya 468 8503, Japan
    Rapid Commun Mass Spectrom 21:1025-33. 2007
    Product ions obtained by tandem mass spectrometry (MS/MS) are quite effective for the amino acid sequencing of linear peptides...
  50. doi Differentiation of the toxicities of silver nanoparticles and silver ions to the Japanese medaka (Oryzias latipes) and the cladoceran Daphnia magna
    Jiwon Kim
    Environmental Toxicology Center, Division of Research and Development, Korea Institute of Toxicology KIT, Yuseong, Daejon, Korea
    Nanotoxicology 5:208-14. 2011
    ..magna was exposed to the column-passed-300 nm AgNP suspensions. There was no acute toxicity with the AgNP suspensions not containing Ag(+)...
  51. pmc A study of the hydration of the alkali metal ions in aqueous solution
    Johan Mähler
    Department of Chemistry, Swedish University of Agricultural Sciences, P O Box 7015, SE 750 07 Uppsala, Sweden
    Inorg Chem 51:425-38. 2012
    The hydration of the alkali metal ions in aqueous solution has been studied by large angle X-ray scattering (LAXS) and double difference infrared spectroscopy (DDIR)...
  52. doi Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases
    Leonid Breydo
    Department of Molecular Medicine, College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd, MDC07, Tampa, Florida 33612, USA
    Metallomics 3:1163-80. 2011
    ..This review examines the effects of metal ion binding on the aggregation pathways of IDPs found in neurodegenerative diseases...
  53. doi Phospholemman (FXYD1) raises the affinity of the human α1β1 isoform of Na,K-ATPase for Na ions
    Erica Cirri
    Department of Biology, University of Konstanz, 78464 Konstanz, Germany
    Biochemistry 50:3736-48. 2011
    ..The electrochromic dye RH421 which monitors binding to and release of ions from the binding sites has been applied in equilibrium titration experiments to determine ion binding affinities ..
  54. doi Counting ion and water molecules in a streaming file through the open-filter structure of the K channel
    Masayuki Iwamoto
    Department of Molecular Physiology and Biophysics, University of Fukui Faculty of Medical Sciences, Eiheiji cho, Yoshida gun, Fukui 910 1193, Japan
    J Neurosci 31:12180-8. 2011
    The mechanisms underlying the selective permeation of ions through channel molecules are a fundamental issue related to understanding how neurons exert their functions...
  55. pmc Metal ions: supporting actors in the playbook of small ribozymes
    Alexander E Johnson-Buck
    Department of Chemistry, University of Michigan, 930 N University, Ann Arbor, MI 48109 1055, USA
    Met Ions Life Sci 9:175-96. 2011
    ..Nevertheless, under physiologic conditions, metal ions are essential for the proper folding and function of the small ribozymes, the most effective of these being ..
  56. ncbi Label-free fluorescent detection of ions, proteins, and small molecules using structure-switching aptamers, SYBR Gold, and exonuclease I
    Dongmei Zheng
    Department of Chemistry, Capital Normal University, Beijing, China
    Anal Chem 84:3554-60. 2012
    ..aptamers (SSAs), SYBR Gold, and exonuclease I to detect a broad range of targets including inorganic ions, proteins, and small molecules...
  57. doi Antimicrobial action of essential oil vapours and negative air ions against Pseudomonas fluorescens
    A K Tyagi
    Applied Microbiology Laboratory, Centre for Rural Development and Technology, Indian Institute of Technology Delhi, New Delhi 110016, India
    Int J Food Microbiol 143:205-10. 2010
    ..to investigate the antibacterial activity of essential oil (in liquid as well as in vapour phase) and negative air ions (NAI) against Pseudomonas fluorescens...
  58. doi Differential effect of common ligands and molecular oxygen on antimicrobial activity of silver nanoparticles versus silver ions
    Zong Ming Xiu
    Department of Civil and Environmental Engineering, Rice University, Houston, Texas 77005, USA
    Environ Sci Technol 45:9003-8. 2011
    ..Overall, these results show that the presence of O₂ or common ligands can differentially affect the toxicity of AgNPs vs Ag(+), and underscore the importance of water chemistry in the mode of action of AgNPs...
  59. pmc Neutralizing mutations of carboxylates that bind metal 2 in T5 flap endonuclease result in an enzyme that still requires two metal ions
    Christopher G Tomlinson
    Centre for Chemical Biology, Department of Chemistry, Krebs Institute, University of Sheffield, Sheffield S3 7HF, United Kingdom
    J Biol Chem 286:30878-87. 2011
    ..The spacing of the two metal ions observed in T5FEN structures appears to preclude this mechanism...
  60. doi A yolk-shell design for stabilized and scalable li-ion battery alloy anodes
    Nian Liu
    Department of Chemistry, Stanford University, Stanford, California 94305, United States
    Nano Lett 12:3315-21. 2012
    ..High capacity (∼2800 mAh/g at C/10), long cycle life (1000 cycles with 74% capacity retention), and high Coulombic efficiency (99.84%) have been realized in this yolk-shell structured Si electrode...
  61. ncbi Predictive toxicology of cobalt nanoparticles and ions: comparative in vitro study of different cellular models using methods of knowledge discovery from data
    Limor Horev-Azaria
    Department of Physiology and Pharmacology, Faculty of Medicine, and the Marian Gertner Institute for Medical Nanosystems, Tel Aviv University, Tel Aviv 69978, Israel
    Toxicol Sci 122:489-501. 2011
    ..The toxicological effects of cobalt nanoparticles (Co-NPs) aggregates were examined and compared with those of cobalt ions (Co-ions) using six different cell lines representing lung, liver, kidney, intestine, and the immune system...
  62. pmc Ion selectivity of alpha-hemolysin with beta-cyclodextrin adapter. II. Multi-ion effects studied with grand canonical Monte Carlo/Brownian dynamics simulations
    Bernhard Egwolf
    Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA
    J Phys Chem B 114:2901-9. 2010
    ..the potential of mean force (PMF) and characterized the self-diffusion coefficients of isolated K(+) and Cl(-) ions using molecular dynamics simulations (Y. Luo et al...
  63. pmc A proteomics grade electron transfer dissociation-enabled hybrid linear ion trap-orbitrap mass spectrometer
    Graeme C McAlister
    Department of Chemistry and Biomolecular Chemistry, University of Wisconsin, Madison, WI 53706, USA
    J Proteome Res 7:3127-36. 2008
    ..Following ion/ion reaction in the QLT, ETD product ions are mass-to-charge (m/z) analyzed in either the QLT (for speed and sensitivity) or the orbitrap (for mass ..
  64. doi Ionomics: The functional genomics of elements
    Ivan Baxter
    Research Computational Biologist, USDA ARS Plant Genetics, Donald Danforth Plant Sciences Center, St Louis, MO 63132, USA
    Brief Funct Genomics 9:149-56. 2010
    ..In this review, I will discuss some of the advantages and limitations of the ionomics approach as well as the important parameters to consider when designing ionomics experiments, and how to evaluate ionomics data...
  65. doi Metal is not inert: role of metal ions released by biocorrosion in aseptic loosening--current concepts
    Dieter Cadosch
    School of Anatomy and Human Biology, University of Western Australia, Crawley, Australia
    J Biomed Mater Res A 91:1252-62. 2009
    ..mechanisms of metal implant corrosion in the human body, which lead to the release of significant levels of metal ions into the peri-implant tissues and the systemic blood circulation...
  66. ncbi Peptide sequence scrambling through cyclization of b(5) ions
    Alex G Harrison
    Department of Chemistry, University of Toronto, Toronto, Canada
    J Am Soc Mass Spectrom 19:1776-80. 2008
    The CID mass spectra of the MH(+) ions and the b(5) ions derived therefrom have been determined for the hexapeptides YAAAAA, AYAAAA, AAYAAA, AAAYAA, and AAAAYA...
  67. pmc Fundamentals of traveling wave ion mobility spectrometry
    Alexandre A Shvartsburg
    Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Anal Chem 80:9689-99. 2008
    ..The major predicted trends are in agreement with TW IMS measurements for peptide ions as a function of mobility, wave amplitude, and gas pressure...
  68. ncbi Metals ions and neurodegeneration
    Francisco Molina-Holgado
    Wolfson Centre for Age Related Diseases, King s College, London, UK
    Biometals 20:639-54. 2007
    ..such as protein aggregation and oxidative stress, both of which are associated with the involvement of metal ions. In this review Alzheimer's disease and Parkinson's disease are mainly discussed, with the aim of identifying ..
  69. doi Stable prenucleation calcium carbonate clusters
    Denis Gebauer
    Max Planck Institute of Colloids and Interfaces, Research Campus Golm, Am Muhlenberg 1, D 14424 Potsdam, Germany
    Science 322:1819-22. 2008
    ..Huge amounts of carbon dioxide are retained as carbonate ions, and calcium ions represent a major contribution to water hardness...
  70. ncbi Salt dependence of ion transport and DNA translocation through solid-state nanopores
    Ralph M M Smeets
    Kavli Institute of Nanoscience, Delft University of Technology, The Netherlands
    Nano Lett 6:89-95. 2006
    ..We demonstrate that the two competing effects cancel at a KCl concentration of 370 +/- 40 mM...
  71. pmc Brownian dynamics simulations of ion transport through the VDAC
    Kyu Il Lee
    Center for Bioinformatics, University of Kansas, Lawrence, Kansas, USA
    Biophys J 100:611-9. 2011
    ..The difference in ion selectivity between the wild-type and the mutants is the result of altered potential of mean force profiles that are dominated by the electrostatic interactions...
  72. pmc Molecular dynamics studies of ion permeation in VDAC
    Huan Rui
    Department of Molecular Biosciences and Center for Bioinformatics, The University of Kansas, Lawrence, Kansas, USA
    Biophys J 100:602-10. 2011
    ..This difference leads to the anion selectivity of VDAC...
  73. pmc Semi-quantitative and structural metabolic phenotyping by direct infusion ion trap mass spectrometry and its application in genetical metabolomics
    Albert Koulman
    AgResearch Grasslands Research Centre, Private Bag 11008, Palmerston North, New Zealand
    Rapid Commun Mass Spectrom 23:2253-63. 2009
    ..Of the top 100 MS(1) bins, 22 ions gave one or more reproducible QTL across the 2 years.
  74. pmc Colorimetric detection of DNA, small molecules, proteins, and ions using unmodified gold nanoparticles and conjugated polyelectrolytes
    Fan Xia
    Department of Chemistry and Biochemistry, Center for Polymers and Organic Solids, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 107:10837-41. 2010
    ..to detect a broad range of targets including nucleic acid (DNA) sequences, proteins, small molecules, and inorganic ions. This nearly "universal" biosensor approach is based on the observation that, while the conjugated polyelectrolyte ..
  75. doi Dynamics characterization of fully hydrated bacterial cell walls by solid-state NMR: evidence for cooperative binding of metal ions
    Thomas Kern
    Institut de Biologie Structurale, UMR5075 CEA CNRS UJF, 38027 Grenoble, France
    J Am Chem Soc 132:10911-9. 2010
    ..We have further observed complexation with divalent ions, highlighting an important structural aspect of gram-positive cell wall architecture...
  76. pmc High concentrations of Na+ and Cl- ions in soil solution have simultaneous detrimental effects on growth of faba bean under salinity stress
    Ehsan Tavakkoli
    School of Agriculture, Food and Wine, Waite Campus, The University of Adelaide, PMB 1, Glen Osmond, South Australia 5064, Australia
    J Exp Bot 61:4449-59. 2010
    Despite the fact that most plants accumulate both sodium (Na(+)) and chloride (Cl(-)) ions to high concentration in their shoot tissues when grown in saline soils, most research on salt tolerance in annual plants has focused on the toxic ..
  77. ncbi A new tool for tissue engineers: ions as regulators of morphogenesis during development and regeneration
    DANY SPENCER ADAMS
    Forsyth Center for Regenerative and Developmental Biology, The Forsyth Institute, and Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    Tissue Eng Part A 14:1461-8. 2008
    ..Biology, we are examining a different set of signals, specifically bioelectric signals (the regulated movement of ions across membranes), including membrane voltage, pH, and gap junction activity and gating...
  78. doi Silver ions induce oxidative stress and intracellular zinc release in human skin fibroblasts
    Miriam M Cortese-Krott
    Department of Internal Medicine B, Cardiovascular Research Laboratory, Medical Faculty of the Heinrich Heine University Düsseldorf, D 40225 Dusseldorf, Germany
    Free Radic Biol Med 47:1570-7. 2009
    ..The aim of this study was to investigate whether the toxicity of silver ions, in analogy to other transition metal ions, depends on pro-oxidant effects...
  79. doi Broadening of 1H NMR signals in the spectra of heparin and OSCS by paramagnetic transition metal ions. The use of EDTA to sharpen the signals
    Ian McEwen
    Medical Products Agency, Box 26, SE 75103 Uppsala, Sweden
    J Pharm Biomed Anal 51:733-5. 2010
    ..chondroitin sulphate (OSCS) are occasionally broad or very broad owing to the presence of paramagnetic metal ions in those polysaccharides...
  80. pmc A positive regulatory loop between foxi3a and foxi3b is essential for specification and differentiation of zebrafish epidermal ionocytes
    Chung Der Hsiao
    Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
    PLoS ONE 2:e302. 2007
    Epidermal ionocytes play essential roles in the transepithelial transportation of ions, water, and acid-base balance in fish embryos before their branchial counterparts are fully functional...
  81. ncbi The activity of selected RB69 DNA polymerase mutants can be restored by manganese ions: the existence of alternative metal ion ligands used during the polymerization cycle
    E Zakharova
    Department of Molecular Biophysics and Biochemistry, Yale University, 333 Cedar Street, New Haven, Connecticut 06520, USA
    Biochemistry 43:6587-95. 2004
    ..two different RB69 pol conformations, suggest that these acidic residues serve as alternative ligands for the metal ions destined to occupy the A and B catalytic sites...
  82. ncbi Karyotypes of human lymphocytes exposed to high-energy iron ions
    M Durante
    Dipartimento di Scienze Fisiche, Universita Federico II, Napoli, Italy
    Radiat Res 158:581-90. 2002
    ..mFISH) in human peripheral blood lymphocytes after in vitro exposure to gamma rays or accelerated (56)Fe ions (1 GeV/nucleon, 145 keV/microm) at Brookhaven National Laboratory (Upton, NY). Doses of 0...
  83. ncbi CN- secondary ions form by recombination as demonstrated using multi-isotope mass spectrometry of 13C- and 15N-labeled polyglycine
    G McMahon
    National Resource for Imaging Mass Spectrometry, Harvard Medical School and Brigham and Women s Hospital, Cambridge, Massachusetts 02139, USA
    J Am Soc Mass Spectrom 17:1181-7. 2006
    We have studied the mechanism of formation CN- secondary ions under Cs+ primary ion bombardment...
  84. ncbi Diagnostic ions for the rapid analysis by nano-electrospray ionization quadrupole time-of-flight mass spectrometry of O-glycans from human mucins
    Catherine Robbe
    Unité Mixte de Recherche CNRS USTL 8576, Glycobiologie Structurale et Fonctionnelle, IFR 118, Université des Sciences et Technologies de Lille 1, 59655 Villeneuve d Ascq cedex, France
    Rapid Commun Mass Spectrom 18:412-20. 2004
    ..amounts of oligosaccharides previously analyzed by nuclear magnetic resonance (NMR), series of diagnostic ions relevant to the structural characterization of O-glycans were deduced...
  85. pmc Molecular mechanisms of calcium and magnesium binding to parvalbumin
    M Susan Cates
    Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005, USA
    Biophys J 82:1133-46. 2002
    ..the transition from Ca(2+) to Mg(2+) coordination by varying the van der Waals parameters for the bound metal ions. The glutamate at position 12 could be accurately and reversibly seen to be a source of selective bidentate ..
  86. pmc Structure and phase diagram of nucleosome core particles aggregated by multivalent cations
    Aurelie Bertin
    Laboratoire de Physique des Solides, CNRS UMR 8502, Université Orsay Sud, Paris, France
    Biophys J 93:3652-63. 2007
    ..We address the question of the effect of multivalent ions on the interactions and mutual organization of the chromatin structural units, the nucleosome core particles (NCPs)...
  87. ncbi Focus formation of DNA repair proteins in normal and repair-deficient cells irradiated with high-LET ions
    Karin H Karlsson
    Division of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, SE 75185 Uppsala, Sweden
    Radiat Res 161:517-27. 2004
    ..in normal cells and in cells lacking DNA-PKcs (M059J) or ATM (GM2052D) after irradiation with high-LET nitrogen ions or low-LET photons. There was a rapid formation of MRE11 and gamma-H2AX foci, and 0...
  88. ncbi Role of chloride ions in modulation of the interaction between von Willebrand factor and ADAMTS-13
    Raimondo De Cristofaro
    Hemostasis Research Centre, Institute of Internal Medicine and Geriatrics, Catholic University School of Medicine, Rome, Italy
    J Biol Chem 280:23295-302. 2005
    ..In this study, the role of ions on the ADAMTS-13/VWF interaction was investigated. In the presence of 1...
  89. ncbi Ionization and transmission efficiency in an electrospray ionization-mass spectrometry interface
    Jason S Page
    Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    J Am Soc Mass Spectrom 18:1582-90. 2007
    ..Current transmitted as gas-phase ions was differentiated from charged droplets and solvent clusters by measuring sensitivity with a single quadrupole ..
  90. ncbi Evidence for many resolvable structures within conformation types of electrosprayed ubiquitin ions
    Stormy L Koeniger
    Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA
    J Phys Chem B 110:7017-21. 2006
    ..ion mobility spectrometry approach combined with mass spectrometry has been used to examine ubiquitin ions in the gas phase...
  91. ncbi The uptake of titanium ions by hydroxyapatite particles-structural changes and possible mechanisms
    Cristina Castro Ribeiro
    INEB Instituto de Engenharia Biomedica, Laboratorio de Biomateriais, Rua do Campo Alegre 823, Porto 4150 180, Portugal
    Biomaterials 27:1749-61. 2006
    In order to understand the effect of titanium ions on the molecular structure of hydroxyapatite (HAp), HAp powders were incubated in solutions with different titanium concentrations...
  92. ncbi Ionomics and the study of the plant ionome
    David E Salt
    Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907, USA
    Annu Rev Plant Biol 59:709-33. 2008
    ..In this review we describe the analytical and bioinformatics aspects of ionomics, as well as its application as a functional genomics tool...
  93. pmc Formation of a wrapped DNA-protein interface: experimental characterization and analysis of the large contributions of ions and water to the thermodynamics of binding IHF to H' DNA
    Kirk A Vander Meulen
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    J Mol Biol 377:9-27. 2008
    ..7+/-0.4 at constant KCl activity, indicating the net release of ca. 150 H(2)O molecules from anionic surface...
  94. pmc Stochastic binding of Ca2+ ions in the dyadic cleft; continuous versus random walk description of diffusion
    Johan Hake
    Simula Research Laboratory, Lysaker, Norway
    Biophys J 94:4184-201. 2008
    ..We study the stochastic binding of single Ca(2+) ions to receptors in the cleft using two different models of diffusion: a stochastic and discrete Random Walk (RW) model,..
  95. ncbi Preparing protein microarrays by soft-landing of mass-selected ions
    Zheng Ouyang
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Science 301:1351-4. 2003
    ..Deposited lysozyme and trypsin retained their biological activity. Multiply charged ions of protein kinase A catalytic subunit and hexokinase were also soft-landed into glycerol-based liquid surfaces...
  96. ncbi Effect of different salt ions on the propensity of aggregation and on the structure of Alzheimer's abeta(1-40) amyloid fibrils
    Karolin Klement
    Leibniz Institut für Altersforschung, Beutenbergstrasse 11, D 07745 Jena, Germany
    J Mol Biol 373:1321-33. 2007
    ..One such factor affecting aggregation is the presence and concentration of salt ions. We have examined the effects of salt ions on the aggregation propensity of Alzheimer's Abeta(1-40) peptide and on ..
  97. pmc Top-down mass spectrometry of a 29-kDa protein for characterization of any posttranslational modification to within one residue
    Siu Kwan Sze
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853 1301, USA
    Proc Natl Acad Sci U S A 99:1774-9. 2002
    ..This result has been achieved with electron-capture dissociation by minimizing the further cleavage of primary product ions and by denaturing the tertiary noncovalent bonding of the molecular ions under a variety of conditions.
  98. pmc Molecular dynamics of a protein surface: ion-residues interactions
    Ran Friedman
    Laser Laboratory for Fast Reactions in Biology, Department of Biochemistry, The George S Wise Faculty for Life Sciences, Tel Aviv University, Israel
    Biophys J 89:768-81. 2005
    ..this notion was further investigated by the use of molecular dynamics simulations, where Na(+) and Cl(-) are the ions under study, thus avoiding the necessity for quantum mechanical calculations...
  99. ncbi Where do all the ions go? The cellular basis of differential ion accumulation in leaf cells
    A J Karley
    Dept of Biology, University of York, PO Box 373, York, UK YO10 5YW
    Trends Plant Sci 5:465-70. 2000
    Leaf cells accumulate solutes differently depending on their cell type. The accumulation profiles of inorganic ions have been well documented for the mesophyll and epidermis, particularly in cereals...
  100. ncbi Carbon ion radiotherapy for pediatric patients and young adults treated for tumors of the skull base
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
    Cancer 115:1348-55. 2009
    ..The current study was conducted to evaluate the outcome of carbon ion radiotherapy (RT) in children and young adults with skull base chordomas and chondrosarcomas...
  101. ncbi Detailed unfolding and folding of gaseous ubiquitin ions characterized by electron capture dissociation
    Kathrin Breuker
    Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York 14853 1301, USA
    J Am Chem Soc 124:6407-20. 2002
    The unfolding enthalpy of the native state of ubiquitin in solution is 5 to 8 times that of its gaseous ions, as determined by electron capture dissociation (ECD) mass spectrometry...

Research Grants73

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  2. National Biomedical EPR Center
    James Hyde; Fiscal Year: 2003
    ..the HF EPR development is the application of this spectroscopy for paramagnetic metal ion systems including S-state ions and the integer spin systems with large zero field splitting (ZFS)...
  3. 2007 NIH Director's Pioneer Award Program (DP1)
    Rustem Ismagilov; Fiscal Year: 2009
    ..These two technologies will be used together to understand protein aggregation and aging, and may lead to new hypothesis and molecules for controlling these processes. ..
  4. Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer's
    Padmakar Kulkarni; Fiscal Year: 2010
    ..Plaque is comprised of aggregated fibrils of beta amyloid (A[unreadable]) collocated with transition metal ions such as Zn, Cu, and Fe, that are present in the brain...
  5. Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer's
    Padmakar Kulkarni; Fiscal Year: 2009
    ..Plaque is comprised of aggregated fibrils of beta amyloid (A[unreadable]) collocated with transition metal ions such as Zn, Cu, and Fe, that are present in the brain...
  6. THIOETHER S-METHYLTRANSFERASE IN METABOLISM OF S AND SE
    JERALD HOFFMAN; Fiscal Year: 1992
    ..The same system will be used to study the conversion of various thiols to methyl thioethers and dimethyl sulfonium ions. 3) To study the sequential methylation of sulfur compounds in vivo in mice...
  7. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert Knight; Fiscal Year: 2009
    ..Injury to the BBB in ischemic stroke often leads to the leakage of ions, water, amino acids, and plasma proteins into the brain and as a result in large strokes significant brain swelling ..
  8. Sub-Wavelength Imaging of Intracellular Metal Ions
    Joseph R Lakowicz; Fiscal Year: 2010
    ..the Challenge Area (06) Enabling Technologies and Specific Challenge Topic 06-GM-106;subcellular imaging of metal ions. Fluorescence microscopy is one of the most widely used methods in the biological sciences...
  9. Sub-Wavelength Imaging of Intracellular Metal Ions
    Joseph Lakowicz; Fiscal Year: 2009
    ..the Challenge Area (06) Enabling Technologies and Specific Challenge Topic 06-GM-106;subcellular imaging of metal ions. Fluorescence microscopy is one of the most widely used methods in the biological sciences...
  10. TREATMENT OF CANCER WITH HEAVY CHARGED PARTICLES
    JOSEPH CASTRO; Fiscal Year: 1993
    This program project will continue research in the use of heavy charged particles such as helium and neon ions for treatment of human cancers...
  11. METAL-DEPENDENT COMPLEXES IN BLOOD COAGULATION
    Barbara Furie; Fiscal Year: 1980
    The role of metal ions in blood coagulation has been a continuing interest of this laboratory...
  12. Individual Predoctoral Dental Scientist Fellowship
    MELISSA ANNE TALBERT; Fiscal Year: 2011
    ..This degradative process releases metal ions, which stimulate fibrous tissue formation, leading to impairment of osseointegration and implant failure...
  13. Individual Predoctoral Dental Scientist Fellowship
    Melissa Talbert; Fiscal Year: 2007
    ..This degradative process releases metal ions, which stimulate fibrous tissue formation, leading to impairment of osseointegration and implant failure...
  14. Individual Predoctoral Dental Scientist Fellowship
    MELISSA ANNE TALBERT; Fiscal Year: 2010
    ..This degradative process releases metal ions, which stimulate fibrous tissue formation, leading to impairment of osseointegration and implant failure...
  15. Individual Predoctoral Dental Scientist Fellowship
    Melissa Talbert; Fiscal Year: 2009
    ..This degradative process releases metal ions, which stimulate fibrous tissue formation, leading to impairment of osseointegration and implant failure...
  16. HYPOTHALAMIC FUNCTION IN EXERCISE THERMOREGULATION
    CARL GISOLFI; Fiscal Year: 1980
    Although acetylcholine (Ach) and the cations Na ion and Ca ions have been implicated in the central (posterior hypothalamus) control of temperature regulation, their participation in the control of specific effector responses has not been ..
  17. METALS/NUCLEOSIDE HYDROPEROXIDE MEDIATED GENETIC DAMAGE
    Krystyna Frenkel; Fiscal Year: 1990
    ..activities of some of the hydroperoxides were significantly increased in the presence of certain transitional metal ions. These metal ions catalyze hydrolysis of hydroperoxides with the formation of reactive oxygen species which ..
  18. ZN-FINGER PROTEINS AS TARGETS OF METAL EMBRYOTOXICITY
    F Sunderman; Fiscal Year: 1990
    This research will test the hypothesis that substitution of foreign metal ions for Zn2+ in finger-loop domains of certain gene-regulating proteins constitutes a molecular mechanism for metal-induced genotoxicity and teratogenicity...
  19. METAL MUTAGENESIS IN VITRO--POLYMERASE KINETICS
    Elizabeth Snow; Fiscal Year: 1993
    ..the mechanisms of mutagenesis induced by the carcinogenic metals nickel and chromium and to use Ni(II) and Cr(III) ions as tools to investigate the enzymatic mechanisms responsible for DNA polymerase function and fidelity...
  20. Monovalent metal ion binding sites in nucleic acids
    SCOTT STROBEL; Fiscal Year: 2002
    ..Metal ions act as essential cofactors in the folding of RNAs...
  21. Monovalent metal ion binding sites in nucleic acids
    SCOTT STROBEL; Fiscal Year: 2001
    ..Metal ions act as essential cofactors in the folding of RNAs...
  22. Monovalent metal ion binding sites in nucleic acids
    SCOTT STROBEL; Fiscal Year: 2004
    ..Metal ions act as essential cofactors in the folding of RNAs...
  23. Monovalent metal ion binding sites in nucleic acids
    SCOTT STROBEL; Fiscal Year: 2003
    ..Metal ions act as essential cofactors in the folding of RNAs...
  24. HEAVY METAL IONS--EUKARYOTIC PROTEIN SYNTHESIS
    Robert Matts; Fiscal Year: 1993
    ..g., toxic heavy metal ions) may adversely affect these processes. The rabbit reticulocyte lysate will be utilized initially as a model system...
  25. FUNCTIONAL ANALYSIS OF A LEAD/CADMIUM/ZINC ATPASE
    Bharati Mitra; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): P1B-type ATPases transport soft metal ions across membranes...
  26. FUNCTIONAL ANALYSIS OF A LEAD/CADMIUM/ZINC ATPASE
    Bharati Mitra; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): P1B-type ATPases transport soft metal ions across membranes...
  27. Structural Basis for Bridged Bimetallic Enzyme Catalysis
    Dagmar Ringe; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): More than half of all proteins contain metal ions. A large percentage of those contain two metal ions (usually first-row transition metals or magnesium) connected by a bridging ligand (usually a ..
  28. Structural Basis for Bridged Bimetallic Enzyme Catalysis
    Dagmar Ringe; Fiscal Year: 2007
    More than half of all proteins contain metal ions. A large percentage of those contain two metal ions (usually first-row transition metals or magnesium) connected by a bridging ligand (usually a carboxylate group)...
  29. STRUCTURE OF NA+/K+ ATPASE
    ROBERT FARLEY; Fiscal Year: 1999
    ..The Na,K-ATPase couples the hydrolysis of intracellular ATP to the transport of Na+ ions out of cells and K+ ions into cells, thereby participating in the mechanism of fluid and electrolyte balance in ..
  30. STRUCTURE OF NA+/K+ ATPASE
    ROBERT FARLEY; Fiscal Year: 2000
    ..The Na,K-ATPase couples the hydrolysis of intracellular ATP to the transport of Na+ ions out of cells and K+ ions into cells, thereby participating in the mechanism of fluid and electrolyte balance in ..
  31. STRUCTURE OF NA+/K+ ATPASE
    ROBERT FARLEY; Fiscal Year: 1993
    ..The Na,K-ATPase couples the hydrolysis of intracellular ATP to the transport of Na+ ions out of cells and K+ ions into cells, thereby participating in the mechanism of fluid and electrolyte balance in ..
  32. Carcinogenesis of Nickel and Epigenetic Control
    Max Costa; Fiscal Year: 2009
    ..The affinity constant of nickel ions binding to this JmjC facial triad is predicted to be at least 3 orders of magnitude greater than that of Fe...
  33. FUNCTIONAL ANALYSIS OF A LEAD/CADMIUM/ZINC ATPASE
    Bharati Mitra; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): P1B-type ATPases transport soft metal ions across membranes...
  34. Catalytic DNA Biosensor for Toxic Metal Ions
    Yi Lu; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Cost-effective catalytic DNA biosensors for heavy metal ions such as lead(II), uranium(VI), mercury(II), and cadmium(II) will be developed...
  35. Carcinogenesis of Nickel and Epigenetic Control
    Max Costa; Fiscal Year: 2007
    ..The affinity constant of nickel ions binding to this JmjC facial triad is predicted to be at least 3 orders of magnitude greater than that of Fe...
  36. Carcinogenesis of Nickel and Epigenetic Control
    Max Costa; Fiscal Year: 2010
    ..The affinity constant of nickel ions binding to this JmjC facial triad is predicted to be at least 3 orders of magnitude greater than that of Fe...
  37. Chemistry of Reactive Intermediates Generated from Benzothiazole Derived Drug Can
    Michael Novak; Fiscal Year: 2009
    ..conversion, by a series of metabolic and chemical reactions, into selective, electrophilic nitrenium or oxenium ions. This project will test of the ability of putative metabolites of the two lead benzothiazoles to generate reactive ..
  38. NOVEL CONCEPT FOR DEGRADATION OF ABSORBABLE POLYMERS
    Chih Chang Chu; Fiscal Year: 1990
    ..It has been known that alkaline hydrolysis of SAS is due to the initial attack of negative-charged [OH-] ions in the physiological buffer to the surface of SAS...
  39. TRANSPORT AND ACTIONS OF METAL IONS
    PATRICIA HINKLE; Fiscal Year: 1992
    ..Fluorescence methods will be used to measure free intracellular metal ions. The importance of voltage-sensitive calcium channels in the transport and toxicity of Cd2+ and Pb2+ will be ..
  40. HORMONE-RESPONSIVE CA2ION LOCALIZATION IN HEPATOCYTES
    DONNER BABCOCK; Fiscal Year: 1980
    ..Recent evidence indicates that alterations in the concentration and distribution of intracellular Ca 2 ions play important roles in mediating hormonal responses in this tissue...
  41. ACID NEUTRALIZATION AND DISPOSAL IN GASTRIC EPITHELIUM
    David Soybel; Fiscal Year: 1992
    ..of luminal acid by preventing diffusion of acid from the lumen into the mucosa and neutralizing or disposing of H+ ions entering the tissue...
  42. NMR STUDIES OF CYTOSOLIC METAL IONS AND OXIDATIVE STRESS
    Raj Gupta; Fiscal Year: 2003
    Our long-range goal is to elucidate the role of intracellular mineral ions (Na+, K+, free Mg2+ & free Ca2+) and oxidative stress in the pathophysiology of essential hypertension and type 2 diabetes...
  43. NMR STUDIES OF CYTOSOLIC METAL IONS AND OXIDATIVE STRESS
    Raj Gupta; Fiscal Year: 2006
    ..DESCRIPTION (provided by applicant): Our long-range goal is to elucidate the role of intracellular mineral ions (Na+, K+, free Mg2+ & free Ca2+) and oxidative stress in the pathophysiology of essential hypertension and type ..
  44. Structural Basis for Bridged Bimetallic Enzyme Cataysis
    Dagmar Ringe; Fiscal Year: 2006
    More than half of all proteins contain metal ions. A large percentage of those contain two metal ions (usually first-row transition metals or magnesium) connected by a bridging ligand (usually a carboxylate group)...
  45. NMR STUDIES OF CYTOSOLIC METAL IONS AND OXIDATIVE STRESS
    Raj Gupta; Fiscal Year: 2005
    Our long-range goal is to elucidate the role of intracellular mineral ions (Na+, K+, free Mg2+ & free Ca2+) and oxidative stress in the pathophysiology of essential hypertension and type 2 diabetes...
  46. Computational Suite for RNA-Targeted Drug Design
    Erin Duffy; Fiscal Year: 2005
    ..We aim to extend and validate computational methods and protocols for treating accurately the interactions among RNA, ions and ligands...
  47. NMR STUDIES OF CYTOSOLIC METAL IONS AND OXIDATIVE STRESS
    Raj Gupta; Fiscal Year: 2004
    Our long-range goal is to elucidate the role of intracellular mineral ions (Na+, K+, free Mg2+ & free Ca2+) and oxidative stress in the pathophysiology of essential hypertension and type 2 diabetes...
  48. Selection, Characterization & Application of Paramagnetic Metal-specific DNAzymes
    Yi Lu; Fiscal Year: 2009
    ..Scientifically, whereas a great deal of knowledge has been accumulated in the roles of metal ions in proteins, much less is known in nucleic acids...
  49. Microvascular Regulation During Intestinal Absorption
    HAROLD BOHLEN; Fiscal Year: 2007
    ..As sodium enters the cell, it is removed in exchange for calcium ions by the sodium/calcium exchanger...
  50. Microvascular Regulation During Intestinal Absorption
    HAROLD BOHLEN; Fiscal Year: 2009
    ..As sodium enters the cell, it is removed in exchange for calcium ions by the sodium/calcium exchanger...
  51. Catalytic DNA Biosensor for Toxic Metal Ions
    Yi Lu; Fiscal Year: 2005
    ..DNA biosensors for on-site, real-time, and cost-effective detection and quantification of multiple heavy metal ions, such as mercury, cadmium and lead, simultaneously will be explored...
  52. Molecular mechanisms of potassium channel permeation and gating
    CRINA MARIA NIMIGEAN; Fiscal Year: 2010
    ..KcsA selectivity using a multidisciplinary three-pronged approach: 1) electrophysiology of KcsA block by impermeant ions using analysis of single- channel current recordings, 2) X-ray crystallography of the blocked KcsA channels, and 3) ..
  53. ELECTRON MONOCHROMATOR TIME-OF-FIGHT MASS SPECTROMETER
    Max Deinzer; Fiscal Year: 2002
    The interaction of low-energy electrons with electrophilic molecules in the production of negative ions is an important chemical process...
  54. ION-EXCHANGE CALCIUM ELECTRODES
    Edward Moore; Fiscal Year: 1980
    ..studies in our laboratory, will utilize ion-exchange electrodes to further define and quantify the binding of Ca ions and Mg ions to the serum proteins, particularly albumin...
  55. ELECTRON MONOCHROMATOR TIME-OF-FIGHT MASS SPECTROMETER
    Max Deinzer; Fiscal Year: 2001
    The interaction of low-energy electrons with electrophilic molecules in the production of negative ions is an important chemical process...
  56. ELECTRON MONOCHROMATOR TIME-OF-FIGHT MASS SPECTROMETER
    Max Deinzer; Fiscal Year: 2000
    The interaction of low-energy electrons with electrophilic molecules in the production of negative ions is an important chemical process...
  57. Molecular Physiology of CLC Chloride Channels
    Tsung Yu Chen; Fiscal Year: 2009
    ..Ion channels help transport ions into and out of the cell, and thus play important roles in many physiological functions...
  58. Molecular Physiology of CLC Chloride Channels
    Tsung Yu Chen; Fiscal Year: 2010
    ..Ion channels help transport ions into and out of the cell, and thus play important roles in many physiological functions...
  59. ROLE OF CALCIUM AND MEMBRANES IN MITOSIS
    PETER HEPLER; Fiscal Year: 1980
    Membranes in the mitotic apparatus (MA) may control the (Ca ions) and thus regulate the assembly and/or function of the motile elements...
  60. Molecular Physiology of CLC Chloride Channels
    Tsung Yu Chen; Fiscal Year: 2010
    ..Ion channels help transport ions into and out of the cell, and thus play important roles in many physiological functions...
  61. EFFECT OF HEAVY METAL IONS--EUKARYOTIC PROTEIN SYNTHESIS
    Robert Matts; Fiscal Year: 1990
    ..play in the control of cellular proliferation, differentiation and aging; and to determine how heavy metal ions, through their effects on protein synthesis, may adversely affect these processes...
  62. GAS PHASE ANALYTICAL CHEMISTRY OF PEPTIDE IONS
    Simon Gaskell; Fiscal Year: 1992
    ..characterization of peptides is currently limited by imperfect understanding of the gas-phase chemistry of peptide ions. Our recent tandem MS analyses of tryptic peptides derived from human a B-100, together with synthetic analogues, ..
  63. Crystallography without crystals: Atomic structure determination of laser oriente
    Wei Kong; Fiscal Year: 2010
    ..In this project, protein ions generated from an electrospray ionization source will be embedded in a pulsed stream of superfluid helium droplets...
  64. Crystallography without crystals: Atomic structure determination of laser oriente
    Wei Kong; Fiscal Year: 2009
    ..In this project, protein ions generated from an electrospray ionization source will be embedded in a pulsed stream of superfluid helium droplets...