chromium compounds

Summary

Summary: Inorganic compounds that contain chromium as an integral part of the molecule.

Top Publications

  1. ncbi Toxicity and carcinogenicity of chromium compounds in humans
    Max Costa
    Department of Environmental Medicine, NYU School of Medicine, New York, New York 10016, USA
    Crit Rev Toxicol 36:155-63. 2006
  2. ncbi Mechanisms of bacterial resistance to chromium compounds
    Martha I Ramírez-Díaz
    Instituto de Investigaciones Quimico Biologicas, Universidad Michoacana de San Nicolas de Hidalgo, Edificio B 3, Ciudad Universitaria, Morelia, Michoacan 58030, Mexico
    Biometals 21:321-32. 2008
  3. ncbi Carrier-controlled ferromagnetism in transparent oxide semiconductors
    J Philip
    Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Mater 5:298-304. 2006
  4. ncbi Study on catalytic incineration of methane using Cr2O3/gamma-Al2O3 as the catalyst
    Ching Huei Wang
    Department of Chemical Engineering, Kao Yuan Institute of Technology, Kaohsiung, Taiwan
    J Environ Sci Health A Tox Hazard Subst Environ Eng 39:1631-41. 2004
  5. ncbi Hydrocarbons in hydrothermal vent fluids: the role of chromium-bearing catalysts
    Dionysis I Foustoukos
    Department of Geology and Geophysics, University of Minnesota, Minneapolis, MN 55455, USA
    Science 304:1002-5. 2004
  6. ncbi Structural and spectroscopic properties of trans-dichlorobis(2,2-dimethyl-1,3-diaminopropane)chromium(III) chloride
    Jong Ha Choi
    Department of Chemistry, Andong National University, Andong, South Korea
    Spectrochim Acta A Mol Biomol Spectrosc 68:796-801. 2007
  7. ncbi Characterization of nonmutagenic Cr(III)-DNA interactions
    Sean A Blankert
    Department of Chemistry, Northern Arizona University, P.O. Box 5698, Flagstaff, Arizona 86011-5698, USA
    Chem Res Toxicol 16:847-54. 2003
  8. ncbi Effects of dietary chromium chloride supplementation on performance, some serum parameters, and immune response in broilers
    Fatma Uyanik
    Department of Biochemistry, Faculty of Veterinary Medicine, University of Erciyes, Kayseri, Turkey
    Biol Trace Elem Res 90:99-115. 2002
  9. ncbi Synthesis of chromium-containing pigments from chromium recovered from leather waste
    Frank J Berry
    Department of Chemistry, The Open University, Milton Keynes, UK
    Waste Manag 22:761-72. 2002
  10. ncbi Cytotoxicity and oxidative mechanisms of different forms of chromium
    Debasis Bagchi
    Department of Pharmacy Sciences, Creighton University School of Pharmacy and Health Professions, 2500 California Plaza, Omaha, NE 68178, USA
    Toxicology 180:5-22. 2002

Research Grants

  1. Chromium Genotoxicity: Response and Repair Mechanisms
    Steven Patierno; Fiscal Year: 2007
  2. PARTICULATE CHROMIUM TOXICITY AND CARCINOGENESIS
    Steven Patierno; Fiscal Year: 2003
  3. DNA CROSSLINKING IN CHROMIUM TOXICITY AND CARCINOGENESIS
    Steven Patierno; Fiscal Year: 2002
  4. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil K Jain; Fiscal Year: 2010
  5. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil K Jain; Fiscal Year: 2010
  6. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil Jain; Fiscal Year: 2009
  7. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil Jain; Fiscal Year: 2007
  8. Adjuvant Therapy for Vascular Inflammation in Diabetes
    Sushil Jain; Fiscal Year: 2006
  9. Metal Carcinogenesis: New Concepts
    Anatoly Zhitkovich; Fiscal Year: 2006
  10. Sensitivity Mechanisms in Chromium Toxicity
    Anatoly Zhitkovich; Fiscal Year: 2007

Detail Information

Publications149 found, 100 shown here

  1. ncbi Toxicity and carcinogenicity of chromium compounds in humans
    Max Costa
    Department of Environmental Medicine, NYU School of Medicine, New York, New York 10016, USA
    Crit Rev Toxicol 36:155-63. 2006
    ..The potential use of this animal model for future risk assessment is discussed...
  2. ncbi Mechanisms of bacterial resistance to chromium compounds
    Martha I Ramírez-Díaz
    Instituto de Investigaciones Quimico Biologicas, Universidad Michoacana de San Nicolas de Hidalgo, Edificio B 3, Ciudad Universitaria, Morelia, Michoacan 58030, Mexico
    Biometals 21:321-32. 2008
    ..Other mechanisms of bacterial resistance to chromate involve the expression of components of the machinery for repair of DNA damage, and systems related to the homeostasis of iron and sulfur...
  3. ncbi Carrier-controlled ferromagnetism in transparent oxide semiconductors
    J Philip
    Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Mater 5:298-304. 2006
    ..Being optically transparent with the above optimal properties, Cr-doped In(2)O(3) emerges as a viable candidate for the development of spin electronics...
  4. ncbi Study on catalytic incineration of methane using Cr2O3/gamma-Al2O3 as the catalyst
    Ching Huei Wang
    Department of Chemical Engineering, Kao Yuan Institute of Technology, Kaohsiung, Taiwan
    J Environ Sci Health A Tox Hazard Subst Environ Eng 39:1631-41. 2004
    ..However, WHSV and inlet concentration of CH4 did affect CH4 conversion noticeably. For complete oxidation of CH4, the reaction temperature required increased with WHSV and inlet CH4 concentration...
  5. ncbi Hydrocarbons in hydrothermal vent fluids: the role of chromium-bearing catalysts
    Dionysis I Foustoukos
    Department of Geology and Geophysics, University of Minnesota, Minneapolis, MN 55455, USA
    Science 304:1002-5. 2004
    ..This in turn could help to support microbial communities now recognized in the subsurface at deep-sea vents...
  6. ncbi Structural and spectroscopic properties of trans-dichlorobis(2,2-dimethyl-1,3-diaminopropane)chromium(III) chloride
    Jong Ha Choi
    Department of Chemistry, Andong National University, Andong, South Korea
    Spectrochim Acta A Mol Biomol Spectrosc 68:796-801. 2007
    ..It is confirmed that the nitrogen atoms of the Me(2)tn ligand have a strong sigma-donor character, but the chloro ligand has weak sigma- and pi-donor properties toward the chromium(III) ion...
  7. ncbi Characterization of nonmutagenic Cr(III)-DNA interactions
    Sean A Blankert
    Department of Chemistry, Northern Arizona University, P.O. Box 5698, Flagstaff, Arizona 86011-5698, USA
    Chem Res Toxicol 16:847-54. 2003
    ..This study provides the first structural evidence for Cr(III)-DNA adducts. A molecular understanding of Cr(III)-DNA interactions will be necessary before we can determine their relevance in Cr(VI)-induced cancers...
  8. ncbi Effects of dietary chromium chloride supplementation on performance, some serum parameters, and immune response in broilers
    Fatma Uyanik
    Department of Biochemistry, Faculty of Veterinary Medicine, University of Erciyes, Kayseri, Turkey
    Biol Trace Elem Res 90:99-115. 2002
    ..All levels of Cr increased the cell-mediated response to phytohemagglutinin. No alterations in tissues were observed by histopathological examinations...
  9. ncbi Synthesis of chromium-containing pigments from chromium recovered from leather waste
    Frank J Berry
    Department of Chemistry, The Open University, Milton Keynes, UK
    Waste Manag 22:761-72. 2002
    ..Colour measurements were compared with those recorded from materials prepared from pure Cr2O3. The leaching of Cr(VI) from the materials was examined by UV spectroscopy...
  10. ncbi Cytotoxicity and oxidative mechanisms of different forms of chromium
    Debasis Bagchi
    Department of Pharmacy Sciences, Creighton University School of Pharmacy and Health Professions, 2500 California Plaza, Omaha, NE 68178, USA
    Toxicology 180:5-22. 2002
    ..The safety of chromium(III) is largely dependent on the ligand, and adequate clinical studies are warranted to demonstrate the safety and efficacy of chromium(III) for human consumption...
  11. ncbi A new method for the treatment of chromite ore processing residues
    Tiangui Wang
    School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China
    J Hazard Mater 149:440-4. 2007
    ..Effects of temperature, dosages of reductants and time on Cr(VI) reduction were investigated. Above 500 degrees C, Cr(VI) can be completely reduced to Cr(III)...
  12. ncbi Ultrastructural damage in chromium picolinate-treated cells: a TEM study. Transmission electron microscopy
    Kevin R Manygoats
    Department of Chemistry, Northern Arizona University, PO Box 5698, Flagstaff, AZ 86011-5698, USA
    J Biol Inorg Chem 7:791-8. 2002
    ..The coordination of Cr(III) by picolinate ligands may alter the cellular chemistry of Cr(III) to make chromium picolinate a toxic form of Cr(III)...
  13. ncbi Stereoselective transformations of trihalomethylcarbinols induced by chromous chloride
    Romain Bejot
    , UMR 7514, , , 74 route du Rhin, BP 24, 67401 Illkirch, France
    Angew Chem Int Ed Engl 44:2008-11. 2005
  14. ncbi Carcinogenic Cr(VI) and the nutritional supplement Cr(III) induce DNA deletions in yeast and mice
    Zhanna Kirpnick-Sobol
    Department of Pathology, Geffen School of Medicine and School of Public Health, University of California at Los Angeles, 650 Charles E. Young Drive South, Los Angeles, CA 90095, USA
    Cancer Res 66:3480-4. 2006
    ..This study concludes that both the environmental contaminant Cr(VI) and the nutritional supplement Cr(III) increase DNA deletions in vitro and in vivo, when ingested via drinking water...
  15. ncbi Bacterial Cr(VI) reduction concurrently improves sunflower (Helianthus Annuus L.) growth
    Muhammad Faisal
    Department of Botany, University of the Punjab, Quaid-e-Azam Campus, 54590 Lahore, Pakistan
    Biotechnol Lett 27:943-7. 2005
    ..O. intermedium caused 30% decrease in chromium uptake in sunflower plant roots under Cr(VI) stress as compared to chromium-free control plants...
  16. ncbi Structural and spectroscopic properties of trans-difluoro(1,4,8,12-tetraazacyclopentadecane)chromium(III) perchlorate hydrate
    Jong Ha Choi
    Department of Chemistry, Andong National University, Andong 760 749, South Korea
    Spectrochim Acta A Mol Biomol Spectrosc 65:1138-43. 2006
    ..It is confirmed that the fluoride has strong sigma- and pi-donor properties toward the chromium(III) ion and the nitrogen atoms of the [15]aneN(4) ligand also have a strong sigma-donor character...
  17. ncbi Synthesis, characterization and properties of chromium(III) complex [Cr(SA)(en)2]Cl.2H2O
    Bin Liu
    Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China
    J Inorg Biochem 100:1462-9. 2006
    ..01M Hepes at pH 7.4. The results show that Cr(III) can be transferred from the complex to apoovotransferrin with the retention of the salicylate acted as a synergistic anion...
  18. ncbi Cr(III) reactivity and foot dermatitis in Cr(VI) positive patients
    Malene Barre Hansen
    Department of Dermatology, The National Allergy Research Centre, University of Copenhagen, Gentofte Hospital, Denmark
    Contact Dermatitis 54:140-4. 2006
    ..However, Cr(VI) allergics having foot eczema and positive or doubtful Cr(III) reactions often had positive reactions to other shoe allergens. Thus, Cr(III) allergy is part of a multiple shoe allergy pattern...
  19. ncbi Application of the Rietveld method to assess chromium(VI) speciation in chromite ore processing residue
    Maria Chrysochoou
    W M Keck Geoenvironmental Laboratory, Stevens Institute of Technology, Castle Point on Hudson, Hoboken NJ 07030, USA
    J Hazard Mater 141:370-7. 2007
    ..The correlation between the average CAC-bound Cr(6+) concentration and the total Cr(6+) for five samples (R(2)=0.94), extracted from different zones and soil borings, suggests that CACs are a primary sink for Cr(6+) in COPR...
  20. ncbi Reactions of *NO2 with chromium(III) complexes with histamine and pyridoxamine ligands studied by the stopped-flow technique
    Dagmara Jacewicz
    Department of General Chemistry, , Sobieskiego 18/19, , Poland
    Anal Biochem 350:256-62. 2006
    ..52 to 9.11 for cis-[Cr(C2O4)(Hpm) (OH2)2]+ and from 6.03 to 8.15 for cis-[Cr(C2O4)(hm)(OH2)2] +. We also determined the thermodynamic activation parameter (E(a)) and the uptake mechanism for each of the coordination compounds studied...
  21. ncbi Chromium activates glucose transporter 4 trafficking and enhances insulin-stimulated glucose transport in 3T3-L1 adipocytes via a cholesterol-dependent mechanism
    Guoli Chen
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Center for Diabetes Research, Indianapolis, Indiana 46202, USA
    Mol Endocrinol 20:857-70. 2006
    ..Moreover, these findings at the level of the cell are consistent with in vivo observations of improved glucose tolerance and decreased circulating cholesterol levels after chromium supplementation...
  22. ncbi Differential impact of ionic and coordinate covalent chromium (Cr)-DNA binding on DNA replication
    Jamie L Fornsaglio
    Department of Pharmacology and Physiology, The George Washington University Medical Center, Washington, DC 20037, USA
    Mol Cell Biochem 279:149-55. 2005
    ..Thus, these results suggest that treatment of living cells with Cr(VI) leads to two modes of Cr-binding, which may have conflicting effects on DNA replication...
  23. ncbi Nucleotide excision repair functions in the removal of chromium-induced DNA damage in mammalian cells
    Travis J O'Brien
    Department of Pharmacology and Physiology, The George Washington University Medical Center, Washington, DC 20037, USA
    Mol Cell Biochem 279:85-95. 2005
    ..Consequently, NER may represent an important mechanism for preventing Cr(VI)-induced mutagenesis and neoplastic transformation...
  24. ncbi Chromium recovery from chrome shaving generated in tanning process
    Mehmet Erdem
    Department of Environmental Engineering, Firat University, 23279 Elazig, Turkey
    J Hazard Mater 129:143-6. 2006
    ..The chromate ions in this solution were reduced by using Na2SO3 and Cr(III) sulphate solution was obtained...
  25. ncbi Combustion of chlorinated VOC on nanostructured chromia aerogel as catalyst and catalyst support
    H Rotter
    Chemical Engineering Department, The Blechner Center for Industrial Catalysis and Process Development, Ben - Gurion University of the Negev, Beer-Sheva, Israel
    Environ Sci Technol 39:6845-50. 2005
    ..5%Pt/Al2O3, respectively. The effects of Pt, Au, Mn, and Ce additives on the performance of CrOOH aerogel in combustion of chlorinated VOC were analyzed related to the materials structure...
  26. ncbi Effects of dengue virus infection on peripheral blood cells of mice exposed to hexavalent chromium with drinking water
    Richa Shrivastava
    Industrial Toxicology Research Centre, Lucknow, India
    Indian J Med Res 122:111-9. 2005
    ..Whether therapeutic doses of chromium (III) compounds may be able to prevent the DV-induced fall in platelet counts, needs to be investigated...
  27. ncbi Safety of trivalent chromium complexes: no evidence for DNA damage in human HaCaT keratinocytes
    Isabelle Hininger
    Laboratoire Nutrition, Vieillissement, Maladies Cardiovasculaires, EA 3746, J Fourier University, Domaine de la Merci, 38700 La Tronche, France
    Free Radic Biol Med 42:1759-65. 2007
    ..These data further support the low toxicity of trivalent Cr complexes used in nutrient supplements...
  28. ncbi Analytical speciation of chromium in in-vitro cultures of chromate-resistant filamentous fungi
    Francisco Javier Acevedo Aguilar
    Instituto de Investigaciones Cientificas, Universidad de Guanajuato, L de Retana N degrees 5, 36000, Guanajuato, Mexico
    Anal Bioanal Chem 392:269-76. 2008
    ....
  29. ncbi Apoptosis of lymphocytes in the presence of Cr(V) complexes: role in Cr(VI)-induced toxicity
    C Vasant
    Central Leather Research Institute, Adyar, Chennai, 600 020, India
    Biochem Biophys Res Commun 285:1354-60. 2001
    ..The intermediates of Cr(V) and radical species in the biotoxic pathways elicited by Cr(VI) seems feasible...
  30. ncbi Chromium nanoparticle exhibits higher absorption efficiency than chromium picolinate and chromium chloride in Caco-2 cell monolayers
    L Y Zha
    Key Laboratory of Molecular Animal Nutrition of Ministry of Education, Feed Science Institute, College of Animal Science, Zhejiang University, Hangzhou, China
    J Anim Physiol Anim Nutr (Berl) 92:131-40. 2008
    ..In addition, CrNano exhibited considerably higher absorption efficiency than both CrPic and CrCl(3) in Caco-2 cell monolayers...
  31. ncbi Improvement of radioactive colloid binding by tumor cells
    L J Anghileri
    Laboratory of Biophysics, Faculty of Medicine, University of Nancy, France
    Tumori 76:217-9. 1990
    ..Poly-lys M.W. 8,000 presents no significant increase, and for the other molecular weights the binding is intermediate...
  32. ncbi Structural modification and aggregation of mucin by chromium(III) complexes
    H Yamini Shrivastava
    Chemical Laboratory, Central Leather Research Institute, Adyar, Chennai 600 020, India
    J Biomol Struct Dyn 20:575-87. 2003
    ..Histochemical analysis supports the contention that complex 2 favors the oligomerisation of PGM and leads to the formation of aggregated mass of macromolecules...
  33. ncbi Hard X-ray microprobe studies of chromium(VI)-treated V79 Chinese hamster lung cells: intracellular mapping of the biotransformation products of a chromium carcinogen
    Carolyn T Dillon
    Centre for Heavy Metals Research, School of Chemistry, University of Sydney, NSW 2006, Australia
    J Biol Inorg Chem 7:640-5. 2002
    ..This is the first study that has enabled the determination of the localization of the biotransformation products of Cr(VI) carcinogens in a target lung cell...
  34. ncbi Efficacy of chromium(III) supplementation on growth, body composition, serum parameters, and tissue chromium in rats
    L Y Zha
    Animal Science College of Zhejiang University, The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Qiutao North Road 164, Hangzhou 310029, China
    Biol Trace Elem Res 119:42-50. 2007
    ..The results indicate that chromium nanocomposite has higher efficacy on growth and body composition compared to the traditional chromium agents...
  35. ncbi Alpha-Tris(2,4-pentanedionato-kappa2O,O')chromium(III) at 290 and 110 K: a new delta phase at 110 K
    Lars S von Chrzanowski
    Bijvoet Center for Biomolecular Research, Crystal and Structural Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Acta Crystallogr C 63:m377-82. 2007
    ..The space group remains P2(1)/c and the phase transition can therefore be considered as klassengleich. The unit-cell volume increases by a factor of six, resulting in six independent molecules in the asymmetric unit...
  36. ncbi Embryotoxicity hazard assessment of methylmercury and chromium using embryonic stem cells
    T C Stummann
    European Centre for the Validation of Alternative Methods ECVAM, TP 580, IHCP, JRC, European Commission, Via Fermi 1, 21020 Ispra VA, Italy
    Toxicology 242:130-43. 2007
    ..In conclusion, our results imply that inclusion of additional target tissues and refinement of the current prediction model may enhance the predictive power of the EST...
  37. ncbi Kinetics of an intratracheally administered chromium catalyst in rats
    J A J Vanoirbeek
    Pneumology (Lung Toxicology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Toxicol Environ Health A 66:393-409. 2003
    ..Exposure to chromium compounds could be monitored by measuring Cr concen-trations in urine (shortly after exposure) and in erythrocytes (..
  38. ncbi Non-enzymatic phosphorylation of bovine serum albumin by Cr(V) complexes: role in Cr(VI)-induced phosphorylation and toxicity
    Chellappa Vasant
    Biochemistry Laboratory, Central Leather Research Institute, Chennai 600020, India
    Mol Cell Biochem 275:153-64. 2005
    ..Based on the results, a possibility that 1, 2 and 3 mimic the function of tyrosine and serine/threonine kinases has been invoked...
  39. ncbi Chromium yeast supplementation improves fasting plasma glucose and LDL-cholesterol in streptozotocin-induced diabetic rats
    Ming-Hoang Lai
    Department of Nursing, Cardinal Tien College of Nursing, Taipei, Taiwan, ROC
    Int J Vitam Nutr Res 76:391-7. 2006
    ..This raises the possibility that Cr yeast supplementation can be considered to improve carbohydrate and lipid metabolism amongst human patients featuring type 2 diabetes mellitus...
  40. ncbi Effects of neutral, cationic, and anionic chromium ascorbate complexes on isolated human mitochondrial and genomic DNA
    Ahmet Nedim Ay
    Department of Chemistry, Hacettepe University, Beytepe Campus 06532, Ankara, Turkey
    J Biochem Mol Biol 36:403-8. 2003
    ..No apparent effect was observed under the applied experimental conditions to facilitate or prevent damage through the ternary amino acid-Cr-DNA adduct formation or binary chromium-amino acid complex formation...
  41. ncbi Subchronic inhalation toxicity of soluble hexavalent chromium trioxide in rats
    Hyeon Yeong Kim
    Occupational Safety and Health Research Institute, Center for Occupational Toxicology, 108 4 Munji dong, Yusong Ku, 305 380, Daejeon, Korea
    Arch Toxicol 78:363-8. 2004
    ..In conclusion, the 13-week repeated exposure with soluble CrO3 demonstrated the injury in SD rats with the no observed adverse effect level (NOAEL) under 0.20 mg/m3...
  42. ncbi Exposure determination and respirator selection under the OSHA Hexavalent Chromium Standards
    Paul Puncochar
    3M Occupational Health and Environmental Safety Division, USA
    Occup Health Saf 75:134-9. 2006
  43. ncbi Microbial stability evaluation of cement-based waste forms at different waste to cement ratio
    Michael A Idachaba
    Cooperative Research Programs, Foster Hall, 904 Chestnut Street, Lincoln University, 65109, Jefferson City, MO, USA
    J Hazard Mater 96:331-40. 2003
    ..On the whole, the maximum percentage chromium leached from the different waste forms was substantially lower than those of the other metals...
  44. ncbi Vitamins deficiency in developing chick during chromium intoxication and protection thereof
    Rajendra Singh Chundawat
    Laboratory of Neurobiology and Toxicology, Department of Biosciences, Saurashtra University, Rajkot, Gujarat 360 005, India
    Toxicology 211:124-31. 2005
    ..Nevertheless, the recovery of vitamins was quick and significant during vitamins and glutathione therapy and in some cases control level was achieved...
  45. ncbi The safety and efficacy of high-dose chromium
    Davis W Lamson
    Bastyr University, Kenmore, WA, USA
    Altern Med Rev 7:218-35. 2002
    The data on the standards for chromium requirements and the safety of various chromium compounds and doses are reviewed...
  46. ncbi The use of air fuel cell cathodes to remove contaminants from spent chromium plating solutions
    K L Huang
    Center of General Education, Chang Jung Christian University, Tainan 711, Taiwan
    Environ Technol 25:39-49. 2004
    ..g., Cr2O3) with minor amount of lead chromate (lead dichromate or lead trichromate) and other chromium solids (Cr black). As expected, the dominant deposit on the lead anode surface was PbO2...
  47. ncbi Complexities of chromium carcinogenesis: role of cellular response, repair and recovery mechanisms
    Susan Ceryak
    Department of Pharmacology and Molecular and Cellular Oncology Program, The George Washington University Medical Center, 2300 I Street NW, Washington, DC 20037, USA
    Mutat Res 533:3-36. 2003
    ..These pertinent issues must be considered in relation to the potential role that each plays in the induction of human respiratory tract cancer by particulate Cr(VI) compounds...
  48. ncbi Incision of trivalent chromium [Cr(III)]-induced DNA damage by Bacillus caldotenax UvrABC endonuclease
    Travis J O'Brien
    Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, United States
    Mutat Res 610:85-92. 2006
    ..Taken together, our data suggest that a sub-fraction of Cr(III)-DNA adducts is recognized and processed by the prokaryotic NER machinery and that ICLs are not necessarily the sole lesions generated by Cr(III) that are substrates for NER...
  49. ncbi Cu, Cr and As distribution in soils adjacent to pressure-treated decks, fences and poles
    Tait Chirenje
    Soil and Water Science Department, University of Florida, Gainesville, FL 32611-0290, USA
    Environ Pollut 124:407-17. 2003
    ..These results are helpful for CCA-treated wood product users to determine the safe use of these structures...
  50. ncbi Influence of Cr(III) and Cr(VI) on the interaction between sparfloxacin and calf thymus DNA
    Dong Sheng Guo
    College of Environment and Resources, Shanxi University, Wucheng Road 580, Taiyuan 030006, China
    J Inorg Biochem 101:644-8. 2007
    ....
  51. ncbi [Determination of chromium(III) and chromium(VI) in water using flow injection on-line preconcentration and separation with flame absorption spectrometric detection]
    Wei-jun Kang
    College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China
    Guang Pu Xue Yu Guang Pu Fen Xi 23:572-5. 2003
    ..L-1 level were 3.41% and 1.80%, and the corresponding detection limits (3 sigma) were 1.03 micrograms.L-1 and 0.54 microgram.L-1, respectively. The satisfactory recovery of 93.48%-107.5% could be obtained from water samples...
  52. ncbi Genesis of hexavalent chromium from natural sources in soil and groundwater
    Christopher Oze
    Department of Geological and Environmental Sciences, Stanford University, Stanford, CA 94305 2115, USA
    Proc Natl Acad Sci U S A 104:6544-9. 2007
    ..Our results demonstrate that Cr(III) within ultramafic- and serpentinite-derived soils/sediments can be oxidized and dissolved through natural processes, leading to hazardous levels of aqueous Cr(VI) in surface and groundwater...
  53. ncbi [Studies on the effects of chromium complexes]
    Liwei Shi
    Institute for Environmental Hygiene and Health Related Product Safety, Chinese Center for Disease Control, Beijing 100021, China
    Wei Sheng Yan Jiu 32:410-2. 2003
    ..The major damaging species responsible for the genotoxicity were Cr(V) or Cr(IV) complexes. However, the function of reactive organic intermediates could not be excluded...
  54. ncbi Mechanisms of chromium toxicity, carcinogenicity and allergenicity: review of the literature from 1985 to 2000
    A D Dayan
    IRG in Toxicology, King's College London, UK
    Hum Exp Toxicol 20:439-51. 2001
    Laboratory and clinical reports about the pathogenesis of the carcinogenicity and allergenicity of chromium compounds published between 1985 and 2000 have been reviewed as a basis for consideration of the pathogenetic mechanisms involved...
  55. ncbi In vivo assays for COX-2
    Chi-Chung Chan
    Merck Frosst Centre for Therapeutic Research, Quebec, Canada
    Methods Mol Biol 225:321-8. 2003
  56. ncbi In vitro availability of ofloxacin in presence of metals essential to human body
    Najma Sultana
    Research Institute of Pharmaceutical Sciences, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:42-7. 2007
    ..4 and 9. The result showed that availability of ofloxacin slightly changed in presence of all metals in all these dissolution mediums...
  57. ncbi Effect of chromium on apolipoprotein A-I expression in HepG2 cells
    Michael J Haas
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, St. Louis University School of Medicine, St. Louis, Missouri, USA
    Nutrition 19:353-7. 2003
    ..Whether similar changes may occur in vivo remains to be shown. However, these observations do not support the use of pharmacologic amounts of chromium supplementation to enhance the cardioprotective lipid profile...
  58. ncbi Epigenetic and gene expression changes related to transgenerational carcinogenesis
    Robert Y-S Cheng
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Mol Carcinog 40:1-11. 2004
    ..These results also support the hypothesis of an epigenetic and/or gene expression-based mechanism for transgenerational carcinogenesis. Published 2004 Wiley-Liss, Inc...
  59. ncbi Autoxidation and toxicant-induced oxidation of lipid and DNA in monkey liver: reduction of molecular damage by melatonin
    J Cabrer
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, 78229-3900, USA
    Pharmacol Toxicol 89:225-30. 2001
    ..The findings provide support for the use of melatonin as suitable agent to reduce damage inflicted by free radical species in primates...
  60. ncbi Nephroprotective action of tocotrienol-rich fraction (TRF) from palm oil against potassium dichromate (K 2 Cr 2 O 7)-induced acute renal injury in rats
    Mohd Rashid Khan
    Department of Biochemistry, Lipid Metabolism Laboratory, Jamia Hamdard Hamdard University, New Delhi 110062, India
    Chem Biol Interact 186:228-38. 2010
    Industrial and occupational exposure to chromium compounds, particularly hexavalent chromium (Cr(VI))-containing compounds are often known to cause acute renal injury (ARI) in humans and animals...
  61. ncbi Workplace carcinogen and pesticide exposures in Costa Rica
    Timo Partanen
    Instituto Regional de Estudios en Sustancias Tóxicas, Facultad de Ciencias de la Tierra y el Mar, Universidad Nacional, Apartado Postal 86, 3000 Heredia, Costa Rica
    Int J Occup Environ Health 9:104-11. 2003
    ..333,000 workers), diesel engine exhaust (278,000), environmental tobacco smoke (71,000), hexavalent chromium compounds (55,000), benzene (52,000), wood dust (32,000), silica dust (27,000), lead and inorganic lead compounds (19,..
  62. ncbi Threshold mechanisms and site specificity in chromium(VI) carcinogenesis
    S De Flora
    Department of Health Sciences, Section of Hygiene and Preventive Medicine, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Carcinogenesis 21:533-41. 2000
    ..since the International Agency for Research on Cancer (IARC) evaluated the carcinogenicity of chromium and chromium compounds. Further studies performed during the last decade have provided further epidemiological, experimental and ..
  63. ncbi Toxicity of sodium molybdate and sodium dichromate to Daphnia magna straus evaluated in acute, chronic, and acetylcholinesterase inhibition tests
    T C Diamantino
    Instituto do Ambiente e Vida, Departamento de Zoologia, Universidade de Coimbra, Largo Marques de Pombal, Coimbra, 3000, Portugal
    Ecotoxicol Environ Saf 45:253-9. 2000
    ..Molybdenum compounds have been studied as alternative to chromium compounds for some industrial applications...
  64. ncbi Evaluation of sequential extraction procedures for soluble and insoluble hexavalent chromium compounds in workplace air samples
    Kevin Ashley
    U S Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Mail Stop R 7, Cincinnati, OH 45226 1998, USA
    J Environ Monit 11:318-25. 2009
    ..The performance data obtained in this work support the Cr(VI) sequential extraction procedures described in the international standards...
  65. ncbi [Urinary excretion of 3-methoxy-4-hydroxymandelic acid, 17-hydroxycorticosteroids and 17-ketosteroids in workers producing iron-manganese alloys]
    A Misiewicz

    Med Pr 42:169-72. 1991
    ..The subjects were exposed to manganese, iron , chromium compounds, thermal radiation, high temperature and noise...
  66. ncbi Occupational exposures and pancreatic cancer: a meta-analysis
    I A Ojajärvi
    Department of Epidemiology and Biostatistics, Finnish Institute of Occupational Health, Topeliuksenk 41A, 00250 Helsinki, Finland
    Occup Environ Med 57:316-24. 2000
    ..Consolidation of epidemiological data on pancreatic cancer and worksite exposures...
  67. ncbi Pycnogenol prevents potassium dichromate K2Cr2O7-induced oxidative damage and nephrotoxicity in rats
    Kehkashan Parveen
    Department of Biochemistry, Lipid Metabolism Laboratory, Jamia Hamdard Hamdard University, New Delhi 110062, India
    Chem Biol Interact 181:343-50. 2009
    Environmental and occupational exposure to chromium compounds, especially hexavalent chromium [Cr(VI)], is widely recognized as a potential nephrotoxic in humans and animals...
  68. ncbi Chromium determination by supercritical fluid chromatography with inductively coupled plasma mass spectrometric and flame ionization detection
    J M Carey
    University of Cincinnati, Department of Chemistry, OH 45221-0172
    J Chromatogr A 662:329-40. 1994
    Supercritical fluid chromatography (SFC) has been investigated for the separation of a pair of beta-ketonate chromium compounds and a thermally labile organochromium dimer...
  69. ncbi Simultaneous analysis of the local and systemic immune responses in mice to study the occupational asthma mechanisms induced by chromium and platinum
    Masarin Ban
    Institut National de Recherche et de Sécurité INRS, Département Polluants et Santé, rue du Morvan, CS 60027, 54019 Vandoeuvre Cedex, France
    Toxicology 277:29-37. 2010
    As a result of industrial development, increased exposure to platinum and chromium compounds and the subsequent development of occupational asthma (OA) has been reported...
  70. ncbi Cr(III) exerts stronger structural effects than Cr(VI) on the human erythrocyte membrane and molecular models
    M Suwalsky
    Faculty of Chemical Sciences, University of Concepcion, Casilla 160 C, Concepcion, Chile
    J Inorg Biochem 102:842-9. 2008
    ..where they are reduced to Cr(III), there are practically no reports on the structural effects induced by chromium compounds on the erythrocyte membrane...
  71. ncbi Hazardous air pollutants and asthma
    George D Leikauf
    Center for Environmental Genetics, Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267 0056, USA
    Environ Health Perspect 110:505-26. 2002
    ..monitoring suggest that aldehydes (especially acrolein and formaldehyde) and metals (especially nickel and chromium compounds) may have possible health risk indices sufficient for additional attention...
  72. ncbi Occupational exposure to dyes, metals, polycyclic aromatic hydrocarbons and other agents and K-ras activation in human exocrine pancreatic cancer
    Juan Alguacil
    Clinical and Molecular Epidemiology of Cancer Unit, Institut Municipal d Investigacio Medica IMIM, Barcelona, Spain
    Int J Cancer 107:635-41. 2003
    ..The association with chromium compounds was stronger for G to T transversions, a finding compatible with experimental studies on mutation spectra ..
  73. ncbi The European standard series in 9 European countries, 2002/2003 -- first results of the European Surveillance System on Contact Allergies
    W Uter
    Department of Medical Informatics, Biometry and Epidemiology, University of Erlangen Nurnberg, Erlangen, Germany
    Contact Dermatitis 53:136-45. 2005
    ..8%) is coming close to the frequency found with the fragrance mix (6.4%). Regarding contact allergy to chromium compounds, different frequencies were noted in the 2 centres focused on occupational dermatitis (2...
  74. ncbi Comparing metabolic effects of six different commercial trivalent chromium compounds
    Harry G Preuss
    Georgetown University Medical Center, Department of Physiology, Washington, DC 20057, United States
    J Inorg Biochem 102:1986-90. 2008
    ..with insulin resistance and diabetes, it is not surprising that many different, commercial trivalent chromium compounds are available on the market...
  75. ncbi Separation of chromium(III) and chromium(VI) by ion chromatography and an inductively coupled plasma mass spectrometer as element-selective detector
    Harald Hagendorfer
    Institute of Chemistry Analytical Chemistry, Karl Franzens University Graz, Universitaetsplatz 1, 8010 Graz, Austria
    Talanta 76:656-61. 2008
    Due to its extensive use in industrial processes, large quantities of chromium compounds are discharged into the environment. Common approaches for the speciation of Cr employ the determination of Cr(VI) and total Cr...
  76. ncbi Lung cancer mortality in nickel/chromium platers, 1946-95
    T Sorahan
    Institute of Occupational Health, University of Birmingham, Edgbaston, Birmingham, UK
    Occup Environ Med 55:236-42. 1998
    ..To investigate mortality from lung cancer in nickel/chromium platers...
  77. ncbi Vitamin C attenuates potassium dichromate-induced nephrotoxicity and alterations in renal brush border membrane enzymes and phosphate transport in rats
    Sabiha Fatima
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, U P, India
    Clin Chim Acta 386:94-9. 2007
    Exposure to chromium compounds can result in nephrotoxicity. The administration of potassium dichromate (K(2)Cr(2)O(7)), a hexavalent chromium compound, results in impairment in functions of renal brush border membrane (BBM).
  78. ncbi Particulate hexavalent chromium is cytotoxic and genotoxic to the North Atlantic right whale (Eubalaena glacialis) lung and skin fibroblasts
    Tânia Li Chen
    Wise Laboratory of Environmental and Genetic Toxicology, University of Southern Maine, Portland, Maine 04103, USA
    Environ Mol Mutagen 50:387-93. 2009
    Hexavalent chromium compounds are present in the atmosphere and oceans and are established mutagens and carcinogens in human and terrestrial mammals. However, the adverse effects of these toxicants in marine mammals are uncertain...
  79. ncbi Monitoring of cellular enzymes in the serum of electroplating workers at Coimbatore
    C P Saraswathy
    Department of Environmental Sciences, Bharathiar University, Coimbatore 614 042, India
    J Environ Biol 28:287-90. 2007
    b>Chromium compounds are potent toxic and carcinogenic substances. With respect to toxicity, hepatic and renal toxicity have been reported both in workers and in animals exposed to chromium (VI)...
  80. ncbi A case-control study on occupational risk factors for sino-nasal cancer
    A d'Errico
    Local Health Unit ASL TO3, Epidemiology Department Piedmont Region, Via Sabaudia 164, Grugliasco TO 10095, Italy
    Occup Environ Med 66:448-55. 2009
    Sino-nasal cancer has been consistently associated with exposure to wood dust, leather dust, nickel and chromium compounds; for other occupational hazards, the findings are somewhat mixed...
  81. ncbi [Exposure to metal compounds in occupational galvanic processes]
    Jolanta Surgiewicz
    Z Zakładu Zagrozeń Chemicznych i Pyłowych, Centralnego Instytutu Ochrony Pracy Państwowego Instytutu Badawczego w Warszawie
    Med Pr 57:123-31. 2006
    ..Workers who deal with galvanic coating are exposed to heavy metal compounds: tin, silver, copper and zinc. Some of them are carcinogenic, for example, hexavalent chromium compounds, nickel and cadmium compounds.
  82. ncbi [Occupational exposure to hexavalent chromium during aircraft painting]
    M Gherardi
    Istituto Superiore per la Prevenzione e la Sicurezza del Lavoro, Dipartimento Igiene del Lavoro, Via Fontana Candida 1, 00040 Monte Porzio Catone, RM
    G Ital Med Lav Ergon 29:553-5. 2007
    ..the chromate are added to primer paint as a corrosion inhibitor of aircrafts surfaces: so hexavalent chromium compounds are available in many primers with a composition ranging from 10% to 13%...
  83. ncbi Chromium oxidation state imaging in mammalian cells exposed in vitro to soluble or particulate chromate compounds
    Richard Ortega
    Laboratoire de Chimie Nucléaire Analytique et Bioenvironnementale, Centre National de la Recherche Scientifique CNRS, Universite de Bordeaux 1, BP 120, Chemin du Solarium, 33175 Gradignan, France
    Chem Res Toxicol 18:1512-9. 2005
    Hexavalent chromium compounds are known carcinogens for the respiratory tract in humans. The mechanism of cell transformation by hexavalent chromium compounds is not fully understood although a role for intracellular reduction is sought...
  84. ncbi Comparative genotoxicity and cytotoxicity of four hexavalent chromium compounds in human bronchial cells
    Sandra S Wise
    Wise Laboratory of Environmental and Genetic Toxicology, Maine Center for Toxicology and Environmental Health, Department of Applied Medical Science, University of Southern Maine, 96 Falmouth Street, Portland, Maine 04104 9300, USA
    Chem Res Toxicol 23:365-72. 2010
    ..The levels of DNA damage measured by gamma-H2A.X foci formation were similar for the three particulate chromium compounds. Corrected for chromium uptake differences, we found that zinc chromate and barium chromate were the most ..
  85. ncbi Extraction of hexavalent chromium from chromated copper arsenate treated wood under alkaline conditions
    Suzana Radivojevic
    Faculty of Forestry University of Toronto, 33 Willcocks St M5S 3B3 Toronto, ON, Canada
    Environ Sci Technol 42:3739-44. 2008
    ..treated wood products because of differences in toxicity between trivalent [Cr(III)] and hexavalent [Cr(VI)] chromium compounds. Hypothetical Cr(VI) fixation products were investigated in CCA type C treated sawdust of aspen and red pine ..
  86. ncbi Reductive activation with cysteine represents a chromium(III)-dependent pathway in the induction of genotoxicity by carcinogenic chromium(VI)
    Anatoly Zhitkovich
    Department of Pathology and Laboratory Medicine, Brown University, Box G B511, Providence, RI 02912, USA
    Environ Health Perspect 110:729-31. 2002
    Induction of DNA damage by carcinogenic hexavalent chromium compounds [Cr(VI)] results from its reduction to lower oxidation states...
  87. ncbi Removal of chromium from aqueous solution using polyaniline--poly ethylene glycol composite
    Majid Riahi Samani
    Department of Environment and Energy, Science and Research Branch, Islamic Azad University, Tehran, Iran
    J Hazard Mater 184:248-54. 2010
    The adsorption of chromium compounds from solutions by a composite of polyaniline/poly ethylene glycol (PANi/PEG) was investigated in this study...
  88. ncbi Killing of chromium-damaged cells by mismatch repair and its relevance to carcinogenesis
    Anatoly Zhitkovich
    Brown University, Center for Genomics and Proteomics, Department of Pathology and Laboratory Medicine, Providence, Rhode Island 02912, USA
    Cell Cycle 4:1050-2. 2005
    Hexavalent chromium compounds are widespread environmental contaminants that are well recognized as human carcinogens and potent respiratory toxicants...
  89. ncbi Occupational risk factors for renal cell carcinoma in Montreal
    M E Parent
    INRS Institut Armand Frappier, Laval, Quebec, Canada
    Am J Ind Med 38:609-18. 2000
    ..Little is known about the role of workplace exposures on the risk of renal cell cancer...
  90. ncbi The somatic white-ivory eye spot test does not detect the same spectrum of genotoxic events as the wing somatic mutation and recombination test in Drosophila melanogaster
    U Graf
    Institute of Toxicology, Swiss Federal Institute of Technology ETH, Schwerzenbach, Switzerland
    Environ Mol Mutagen 27:219-26. 1996
    ..of the genotoxic activity that is due to mitotic recombination was between 84% and 91% for the hexavalent chromium compounds CRO and POC and about 68% for 2,4-D...
  91. ncbi Trivalent chromium induces oxidative stress in goldfish brain
    Oleh V Lushchak
    Department of Biochemistry, Precarpathian National University named after Vassyl Stefanyk, 57 Shevchenko Str, Ivano Frankivsk, 76025, Ukraine
    Chemosphere 75:56-62. 2009
    ..Toxic effects of chromium compounds are partially associated with activation of redox processes...
  92. ncbi Electronic structure and Jahn-Teller effect in GaN:Mn and ZnS:Cr
    F Virot
    Institut Matériaux Microélectronique Nanosciences de Provence, Faculté St Jérôme, Case 142, F 13397 Marseille CEDEX 20, France
    J Phys Condens Matter 23:025503. 2011
    ..The same is true for the complete set of crystal field parameters obtained from the phenomenological model which agrees well with previous optical measurements...
  93. ncbi Removal of copper, chromium and arsenic from preservative-treated wood by chemical extraction-fungal bioleaching
    Reyes Sierra-Alvarez
    Department of Chemical and Environmental Engineering, University of Arizona, Tucson, AZ 85721 0011, USA
    Waste Manag 29:1885-91. 2009
    ..10) followed by a 28-day solid-state fermentation period removed 87% Cu, 80% Cr, and 100% As. These results indicate the potential of the two-stage process for the remediation of preservative-treated wood...
  94. ncbi Molecular aspects of glucose dehydration by chromium chlorides in ionic liquids
    Yanmei Zhang
    Inorganic Materials Chemistry, Schuit Institute of Catalysis, Eindhoven University of Technology, P O Box 513, NL 5600 MB, Eindhoven, The Netherlands
    Chemistry 17:5281-8. 2011
    ..The mechanism involves ring opening of D-glucopyranose coordinated to a single Cr ion, followed by a transient self-organization of catalytic chromium complexes that promotes the rate-determining hydrogen-shift step...
  95. ncbi Decomposition of Cr(V)-diols to Cr(III) complexes by Arthrobacter oxydans
    Nelly Y Tsibakhashvili
    Andronikashvili Institute of Physics, Tbilisi, 0177, Georgia
    Microb Ecol 57:360-6. 2009
    ..Additionally, atomic absorption spectrometry was also employed to examine the time course of total chromium in bacterial cells. This is the first time the kinetics of Cr(III) complexes formation in bacteria is evaluated...
  96. ncbi Synthesis of C14,15-dihydro-C22,25-epi north unit of cephalostatin 1 via "red-ox" modifications of hecogenin acetate
    Seongmin Lee
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    Org Lett 11:5-8. 2009
    ..The key transformations include (i) Cr(VI)-catalyzed E-ring opening, (ii) C17 hydroxylation, and (iii) a base-triggered cyclization cascade...
  97. ncbi The effect of texturized vegetable protein containing soy carbohydrate on oroileal transit of chromic oxide in cannulated dogs
    R C Hill
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA
    J Anim Sci 78:2633-8. 2000
    ..Mean Cr2O3 recovery was 93%. In conclusion, small intestinal transit of Cr2O3 was unaffected by increasing dietary TVP despite marked changes in carbohydrate digestibility...
  98. ncbi Addition of DNA to Cr(VI) and cytochrome b5 containing proteoliposomes leads to generation of DNA strand breaks and Cr(III) complexes
    Griselda R Borthiry
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Chem Biodivers 5:1545-57. 2008
    ..It is concluded that EPR can detect specific Cr(III) complexes that depend on the presence of plasmid DNA and the manner in which the Cr(III) is formed...
  99. ncbi The hazard of chromium exposure to neonates in Guiyu of China
    Yan Li
    Central Laboratory and the Key Immunopathology Laboratory of Guangdong Province, Shantou University Medical College, Shantou, China
    Sci Total Environ 403:99-104. 2008
    ..Chromium pollution is threatening the health of neonates around the recycling sites...
  100. ncbi Absorption of inorganic, trivalent and hexavalent chromium following oral and intrajejunal doses in rats
    H Febel
    Research Institute of Animal Breeding and Nutrition, H 2053 Herceghalom, Hungary
    Acta Vet Hung 49:203-9. 2001
    ..Total retention of chromium given orally ranged around 15 percent of the dose, regardless of the chromium compounds applied. The absorption rate of chromic oxide, which is considered a nonabsorbable compound, was 14...
  101. ncbi Chromium behavior during cement-production processes: a clinkerization, hydration, and leaching study
    Suthatip Sinyoung
    Department of Environmental Engineering, Faculty of Engineering, King Mongkut s University of Technology Thonburi, Bangkok, Thailand
    J Hazard Mater 191:296-305. 2011
    ..Chromium was found to be incorporated in the clinker phase. The formation of new chromium compounds such as Ca(6)Al(4)Cr(2)O(15), Ca(5)Cr(3)O(12), Ca(5)Cr(2)SiO(12), and CaCr(2)O(7), with chromium oxidation ..

Research Grants50

  1. Chromium Genotoxicity: Response and Repair Mechanisms
    Steven Patierno; Fiscal Year: 2007
    Certain chromium compounds are environmentally and occupationally important human respiratory carcinogens that are mutagenic and carcinogenic at exposure levels which induce some growth arrest and apoptotic cell death...
  2. PARTICULATE CHROMIUM TOXICITY AND CARCINOGENESIS
    Steven Patierno; Fiscal Year: 2003
    ..object of the proposed research is to investigate the interaction of particulate and soluble hexavalent chromium compounds with normal human small airway epithelial cells (HSAE) and fibroblasts (HLF), which are representative ..
  3. DNA CROSSLINKING IN CHROMIUM TOXICITY AND CARCINOGENESIS
    Steven Patierno; Fiscal Year: 2002
    The objective of this continuation application is to investigate the interaction of particulate and soluble chromium compounds with normal human small airway epithelial cells (HSAE) and fibroblasts (HLF) which are representative target ..
  4. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil K Jain; Fiscal Year: 2010
    ..The long-term goal is to understand the role of ketosis in CVD and to discover a relatively low-cost dietary supplement that could be used as an adjuvant therapy for CVD prevention in type 1 diabetes. ..
  5. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil K Jain; Fiscal Year: 2010
    ..The long-term goal is to understand the role of ketosis in CVD and to discover a relatively low-cost dietary supplement that could be used as an adjuvant therapy for CVD prevention in type 1 diabetes. ..
  6. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil Jain; Fiscal Year: 2009
    ..The long-term goal is to understand the role of ketosis in CVD and to discover a relatively low-cost dietary supplement that could be used as an adjuvant therapy for CVD prevention in type 1 diabetes. ..
  7. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil Jain; Fiscal Year: 2007
    ..The long-term goal is to understand the role of ketosis in CVD and to discover a relatively low-cost dietary supplement that could be used as an adjuvant therapy for CVD prevention in type 1 diabetes. ..
  8. Adjuvant Therapy for Vascular Inflammation in Diabetes
    Sushil Jain; Fiscal Year: 2006
    ..abstract_text> ..
  9. Metal Carcinogenesis: New Concepts
    Anatoly Zhitkovich; Fiscal Year: 2006
    ....
  10. Sensitivity Mechanisms in Chromium Toxicity
    Anatoly Zhitkovich; Fiscal Year: 2007
    ..The results of this work are expected to advance molecular understanding of Cr(VI) injury in the major target cells and to identify damage processing proteins that enhance toxicity of Cr-DNA modifications. ..
  11. GENOTOXICITY OF CHROMIUM COMPOUNDS
    Anatoly Zhitkovich; Fiscal Year: 2007
    ..abstract_text> ..
  12. GENOTOXICITY OF CHROMIUM COMPOUNDS
    Anatoly Zhitkovich; Fiscal Year: 2010
    ..The completion of the proposed work can lead to the identification of biochemical factors that increase or decrease individual susceptibility to genetic damage by carcinogenic chromium. ..
  13. GENOTOXICITY OF CHROMIUM COMPOUNDS
    Anatoly Zhitkovich; Fiscal Year: 2001
    DESCRIPTION: Exposure to hexavalent chromium compounds has been established to present a significant cancer risk to human respiratory system...
  14. Silyl Migration-Mediated Tandem Bond Formations
    William Moser; Fiscal Year: 2003
    ..On the basis of these results, a study of stereoselective silyl migration-mediated Baylis-Hillman reactions is proposed, along with the application of the method towards solid-phase synthesis. ..
  15. Human Subjects Protection: Fox Chase to the Community
    Robert Young; Fiscal Year: 2003
    ..Provide these programs to Network IRBs. Appraise performance of IRB website. 6) Enhance efficiency of Fox Chase IRB office and staff to handle expanded responsibilities. ..
  16. Protecting Human Subjects at Fox Chase Cancer Center
    Robert Young; Fiscal Year: 2002
    ..These initiatives will accelerate creation of additional levels of protection and education for investigators and staff. Our objective has been and will continue to be to ensure the highest level of human subject's protection possible...
  17. LIPOCORTINS (ANNEXINS) AND METAL-INDUCED MUTAGENESIS
    Fusao Hirata; Fiscal Year: 2003
    ..Our proposed research will provide further insights to understanding of the molecular mechanisms of carcinogenesis, genetic instability and pathological diseases associated with the formation of mutations by heavy metals. ..