calcium phosphates

Summary

Summary: Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements.

Top Publications

  1. ncbi Nanostructured calcium phosphates for biomedical applications: novel synthesis and characterization
    Prashant N Kumta
    Department of Materials Science and Engineering, Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Acta Biomater 1:65-83. 2005
  2. doi Biocompatibility and osteogenicity of degradable Ca-deficient hydroxyapatite scaffolds from calcium phosphate cement for bone tissue engineering
    Han Guo
    Key Laboratory for Ultrafine Materials of Ministry of Education, and Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China
    Acta Biomater 5:268-78. 2009
  3. ncbi Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth
    O Gauthier
    Laboratoire de Chirurgie, Ecole Nationale Veterinaire de Nantes, France
    Biomaterials 19:133-9. 1998
  4. doi Effect of calcium phosphate cements on growth and odontoblastic differentiation in human dental pulp cells
    Sun Kyung Lee
    Department of Oral and Maxillofacial Pathology and Institute of Wonkwang Biomaterials Implant, School of Dentistry, Wonkwang University, Iksan, Korea
    J Endod 36:1537-42. 2010
  5. doi Cell attachment and response to photocured, degradable bone adhesives containing tricalcium phosphate and purmorphamine
    Kris Gellynck
    Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, 256 Gray s Inn Road, London WC1X 8LD, UK
    Acta Biomater 7:2672-7. 2011
  6. pmc Bone substitutes in vertebroplasty
    P F Heini
    Department of Orthopaedic Surgery, Spine Service, Inselspital, University of Bern, Switzerland
    Eur Spine J 10:S205-13. 2001
  7. doi Basic calcium phosphate crystals induce monocyte/macrophage IL-1β secretion through the NLRP3 inflammasome in vitro
    Borbála Pazár
    Department of Rheumatology, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    J Immunol 186:2495-502. 2011
  8. ncbi The performance of BMP-2 loaded TCP/HAP porous ceramics with a polyelectrolyte multilayer film coating
    Thomas Crouzier
    LMGP, UMR 5628 CNRS INPG, 3 parvis Louis Neel, 38016 Grenoble, France
    Biomaterials 32:7543-54. 2011
  9. doi Influence of β-tricalcium phosphate granule size and morphology on tissue reaction in vivo
    Shahram Ghanaati
    Institute of Pathology, REPAIR Laboratory, Johannes Gutenberg University Mainz, 55101 Mainz, Germany
    Acta Biomater 6:4476-87. 2010
  10. doi Paracrine effect of canine allogenic umbilical cord blood-derived mesenchymal stromal cells mixed with beta-tricalcium phosphate on bone regeneration in ectopic implantations
    Ye Eun Byeon
    Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University, Seoul, Korea
    Cytotherapy 12:626-36. 2010

Research Grants

Detail Information

Publications307 found, 100 shown here

  1. ncbi Nanostructured calcium phosphates for biomedical applications: novel synthesis and characterization
    Prashant N Kumta
    Department of Materials Science and Engineering, Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Acta Biomater 1:65-83. 2005
    ..This paper illustrates our approach to implement calcium phosphates as gene delivery agents...
  2. doi Biocompatibility and osteogenicity of degradable Ca-deficient hydroxyapatite scaffolds from calcium phosphate cement for bone tissue engineering
    Han Guo
    Key Laboratory for Ultrafine Materials of Ministry of Education, and Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China
    Acta Biomater 5:268-78. 2009
    ..However, the CDHA scaffolds showed as good biocompatibility and osteogenicity as the hybrid ones at 8 weeks. These results indicate that the CDHA scaffolds fulfill the basic requirements of bone tissue engineering scaffold...
  3. ncbi Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth
    O Gauthier
    Laboratoire de Chirurgie, Ecole Nationale Veterinaire de Nantes, France
    Biomaterials 19:133-9. 1998
    ..MBCP implants with 565 microm pore diameter and 40% macroporosity represented the optimal association for homogeneous and abundant bone ingrowth...
  4. doi Effect of calcium phosphate cements on growth and odontoblastic differentiation in human dental pulp cells
    Sun Kyung Lee
    Department of Oral and Maxillofacial Pathology and Institute of Wonkwang Biomaterials Implant, School of Dentistry, Wonkwang University, Iksan, Korea
    J Endod 36:1537-42. 2010
    ..The purpose of this study was to investigate the effects of CPCs on the mechanical properties, growth, and odontoblastic differentiation in HDPCs compared with Portland cement (PC) and mineral trioxide aggregate (MTA)...
  5. doi Cell attachment and response to photocured, degradable bone adhesives containing tricalcium phosphate and purmorphamine
    Kris Gellynck
    Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, 256 Gray s Inn Road, London WC1X 8LD, UK
    Acta Biomater 7:2672-7. 2011
    ..This suggests drug release levels were very low. Purmorphamine and β-TCP incorporation in PPLM adhesives might, therefore, provide prolonged enhancement of in vivo bone repair without systemic drug side-effects...
  6. pmc Bone substitutes in vertebroplasty
    P F Heini
    Department of Orthopaedic Surgery, Spine Service, Inselspital, University of Bern, Switzerland
    Eur Spine J 10:S205-13. 2001
    ..Animal studies confirm their biocompatibility and osteoconductivity. However, handling problems and the limited radiopacity of these cements currently preclude their clinical use...
  7. doi Basic calcium phosphate crystals induce monocyte/macrophage IL-1β secretion through the NLRP3 inflammasome in vitro
    Borbála Pazár
    Department of Rheumatology, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    J Immunol 186:2495-502. 2011
    ..Furthermore, we speculate that IL-1 blockade could be a novel strategy to inhibit BCP-induced inflammation in human disease...
  8. ncbi The performance of BMP-2 loaded TCP/HAP porous ceramics with a polyelectrolyte multilayer film coating
    Thomas Crouzier
    LMGP, UMR 5628 CNRS INPG, 3 parvis Louis Neel, 38016 Grenoble, France
    Biomaterials 32:7543-54. 2011
    ..This opens perspective for coating these bioactive PEM on other types of implantable materials, including metal alloy that do not exhibit any affinity for rhBMP-2...
  9. doi Influence of β-tricalcium phosphate granule size and morphology on tissue reaction in vivo
    Shahram Ghanaati
    Institute of Pathology, REPAIR Laboratory, Johannes Gutenberg University Mainz, 55101 Mainz, Germany
    Acta Biomater 6:4476-87. 2010
    ..This study demonstrates that variations in the physical properties of a bone substitute material clearly influence the (extent of the) inflammatory reaction and its consequences...
  10. doi Paracrine effect of canine allogenic umbilical cord blood-derived mesenchymal stromal cells mixed with beta-tricalcium phosphate on bone regeneration in ectopic implantations
    Ye Eun Byeon
    Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University, Seoul, Korea
    Cytotherapy 12:626-36. 2010
    ..The aim of this study was to evaluate the paracrine effects of canine umbilical cord blood (cUCB) mesenchymal stromal cells (MSC) mixed with beta-tricalcium phosphate (beta-TCP) on bone regeneration in ectopic implantation...
  11. doi Calcification of articular cartilage in human osteoarthritis
    M Fuerst
    Department of Orthopaedic Surgery, University Medical Center Hamburg Eppendorf, Clinic Bad Bramstedt, Martinistrasse 52, Hamburg, Germany
    Arthritis Rheum 60:2694-703. 2009
    Hypertrophic chondrocyte differentiation is a key step in endochondral ossification that produces basic calcium phosphates (BCPs)...
  12. pmc Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: a review
    Susmita Bose
    W M Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164 2920, USA
    Acta Biomater 8:1401-21. 2012
    b>Calcium phosphates (CaPs) are the most widely used bone substitutes in bone tissue engineering due to their compositional similarities to bone mineral and excellent biocompatibility...
  13. doi Octacalcium phosphate crystals induce inflammation in vivo through interleukin-1 but independent of the NLRP3 inflammasome in mice
    Sharmal Narayan
    Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Arthritis Rheum 63:422-33. 2011
    ..To determine the mechanisms involved in inflammatory responses to octacalcium phosphate (OCP) crystals in vivo...
  14. ncbi Nanostructured calcium phosphates (NanoCaPs) for non-viral gene delivery: influence of the synthesis parameters on transfection efficiency
    Dana Olton
    Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Biomaterials 28:1267-79. 2007
    ..In addition, X-ray diffraction and Fourier transform infrared spectroscopy analyses confirmed that all of the synthesized CaP structures exhibited the hydroxyapatite phase...
  15. ncbi Fast setting calcium phosphate-chitosan scaffold: mechanical properties and biocompatibility
    Hockin H K Xu
    Paffenbarger Research Center, American Dental Association Foundation, USA
    Biomaterials 26:1337-48. 2005
    ..The highly porous scaffold may facilitate bone ingrowth and implant fixation in vivo. In addition, the two to three times increase in strength may help extend the use of CPC to larger repairs in moderately stress-bearing locations...
  16. ncbi Bone formation using human adipose tissue-derived stromal cells and a biodegradable scaffold
    Hidemi Hattori
    Division of Biomedical Engineering, Research Institute, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Biomed Mater Res B Appl Biomater 76:230-9. 2006
    ..The present results show that ATSCs have a similar ability to differentiate into osteoblasts and to synthesize bone in beta-TCP disk as have BMSCs...
  17. doi Tooth root regeneration using dental follicle cell sheets in combination with a dentin matrix - based scaffold
    Bo Yang
    State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, PR China
    Biomaterials 33:2449-61. 2012
    ..Therefore, DFCSs combined with TDM may prove to be a better strategy for the construction of tooth root, and is a prospective approach that could be utilized for the treatment of root or tooth defect or loss in future...
  18. ncbi Calcium-phosphate-silicate composite bone cement: self-setting properties and in vitro bioactivity
    Zhiguang Huan
    Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai, 200050, People s Republic of China
    J Mater Sci Mater Med 20:833-41. 2009
    ..With good hydraulic properties, improved biocompatibility and moderate degradability, the novel DCPD/C(3)S bone cement may be a potential candidate as bone substitute...
  19. ncbi Bone response and mechanical strength of rabbit femoral defects filled with injectable CaP cements containing TGF-beta 1 loaded gelatin microparticles
    Dennis P Link
    Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Biomaterials 29:675-82. 2008
    ..The results of this study showed that CaP/gelatin composites show excellent osteogenic properties and a rapid increase in mechanical strength. The addition of TGF-beta1 significantly enhances the bone remodeling process...
  20. doi The chemical composition of synthetic bone substitutes influences tissue reactions in vivo: histological and histomorphometrical analysis of the cellular inflammatory response to hydroxyapatite, beta-tricalcium phosphate and biphasic calcium phosphate cer
    Shahram Ghanaati
    Institute of Pathology, University Medical Center of the Johannes Gutenberg University Mainz, Germany
    Biomed Mater 7:015005. 2012
    ..Both of these factors are necessary for successful bone tissue regeneration...
  21. doi Annexin 5 overexpression increased articular chondrocyte apoptosis induced by basic calcium phosphate crystals
    H K Ea
    INSERM U606, IFR 139, Hopital Lariboisiere, Paris, France
    Ann Rheum Dis 67:1617-25. 2008
    ..We assessed in vitro whether BCP crystals and overexpression of A5 increased chondrocyte apoptosis...
  22. ncbi A prospective, randomized trial for the prevention of mucositis in patients undergoing hematopoietic stem cell transplantation
    A S Papas
    Department of Oral Medicine, Tufts New England Medical Center, Tufts University School of Dental Medicine, Boston, MA 02111, USA
    Bone Marrow Transplant 31:705-12. 2003
    ....
  23. ncbi Endocultivation: 3D printed customized porous scaffolds for heterotopic bone induction
    Stephan T Becker
    Department of Oral and Maxillofacial Surgery, Christian Albrechts University Kiel, Germany
    Oral Oncol 45:e181-8. 2009
    ..Further studies should explore if the stability of the individually designed blocks is sufficient to cultivate larger replacements without an external matrix for support...
  24. ncbi Surface-mediated gene transfer from nanocomposites of controlled texture
    Hong Shen
    School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, USA
    Nat Mater 3:569-74. 2004
    ..DNA/mineral nanocomposite surfaces represent a promising system for enhancing gene transfer and controlling the extent of gene transfer for various biomedical applications, including tissue engineering or gene therapy of bone...
  25. ncbi Calcium phosphate coated electrospun fiber matrices as scaffolds for bone tissue engineering
    Anandkumar Nandakumar
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, PO Box 217, 7500 AE, The Netherlands
    Langmuir 26:7380-7. 2010
    ..The results of this study showed that the biomimetic method can successfully be used to coat electrospun scaffolds with a calcium phosphate layer, which improved the in vivo bioactivity of the polymer...
  26. ncbi Porous beta tricalcium phosphate scaffolds used as a BMP-2 delivery system for bone tissue engineering
    Jerome Sohier
    INSERM, U791, Laboratory for Osteo articular and Dental Tissue Engineering, Faculty of Dental Surgery, University of Nantes, Nantes, France
    J Biomed Mater Res A 92:1105-14. 2010
    ..These results indicate the suitability of chemically etched beta-TCP scaffolds as BMP-2 carriers, in the context of bone regeneration...
  27. doi Silicon-substituted calcium phosphates - a critical view
    Marc Bohner
    RMS Foundation, Bischmattstrasse 12, CH 2544 Bettlach, Switzerland
    Biomaterials 30:6403-6. 2009
    Nowadays, the scientific community widely accepts the statement that silicon-substituted calcium phosphates have better biological properties compared to pure calcium phosphates...
  28. ncbi Formation of osteoclast-like cells on HA and TCP ceramics
    R Detsch
    BioCer Entwicklungs GmbH, 95447 Bayreuth, Germany
    Acta Biomater 4:139-48. 2008
    ..On the other hand, highly soluble calcium phosphate ceramics like TCP seem to be inappropriate for osteoclast resorption because they produce a high calcium concentration in the osteoclast interface and in the environment...
  29. doi The combined bone forming capacity of human periosteal derived cells and calcium phosphates
    Scott J Roberts
    Laboratory for Skeletal Development and Joint Disorders, Katholieke Universiteit Leuven, Belgium
    Biomaterials 32:4393-405. 2011
    ..This study demonstrates the importance of matching a cell support/biological matrix with a cell type and subsequently has outlined parameters which can be used for the rational selection of biomaterials for bone engineering...
  30. doi Superior mineralization and neovascularization capacity of adult human metaphyseal periosteum-derived cells for skeletal tissue engineering applications
    Daoyun Chen
    Department of Orthopaedic Surgery, Shanghai Sixth People s Hospital, Shanghai Jiaotong University, 600 Yishan Road, Shanghai 200233, PR China
    Int J Mol Med 27:707-13. 2011
    ..In conclusion, hMPCs represent a promising cellular candidate for bone tissue engineering...
  31. ncbi Calcium phosphate cement containing resorbable fibers for short-term reinforcement and macroporosity
    Hockin H K Xu
    Paffenbarger Research Center, American Dental Association Health Foundation, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Biomaterials 23:193-202. 2002
    ..The reinforcement mechanisms appeared to be crack bridging and fiber pullout, the mechanical properties of the CPC matrix also affected the composite properties...
  32. ncbi The effect of the microstructure of beta-tricalcium phosphate on the metabolism of subsequently formed bone tissue
    Takatoshi Okuda
    Department of Oral Pathology and Bone Metabolism, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Biomaterials 28:2612-21. 2007
    ..These results showed that the microstructure of beta-TCP affects the activity of bone cells and subsequent bone replacement...
  33. doi A combination of calcium phosphate and probiotics beneficially influences intestinal lactobacilli and cholesterol metabolism in humans
    Ulrike Trautvetter
    Department of Nutritional Physiology, Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Str 24, D 07743 Jena, Germany
    Clin Nutr 31:230-7. 2012
    ..The study focuses on the influence of a probiotic supplement alone and in combination with a calcium supplement on faecal lactobacilli colonisation and beneficial health effects such as a lowering of blood cholesterol...
  34. ncbi A novel amorphous calcium phosphate polymer ceramic for bone repair: I. Synthesis and characterization
    A M Ambrosio
    Center for Advanced Biomaterials and Tissue Engineering, Department of Chemical Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, Pennsylvania 19104, USA
    J Biomed Mater Res 58:295-301. 2001
    ..Sintering the composite microspheres together yielded a bioresorbable, porous, 3-dimensional scaffold that may be ideal for tissue ingrowth, making this composite scaffold potentially suitable for bone repair applications...
  35. ncbi Calcium phosphate nanoparticles as a novel nonviral vector for efficient transfection of DNA in cancer gene therapy
    Ting Liu
    Xiangya Hospital, Central South University, Changsha 410078, Hunan Province, People s Republic of China
    Cancer Biother Radiopharm 20:141-9. 2005
    ..Our results showed that the CPNP might be a potential vector for gene therapy...
  36. ncbi Calcium phosphate nanoparticles as novel non-viral vectors for targeted gene delivery
    Indrajit Roy
    Department of Chemistry, University of Delhi, Delhi 110007, India
    Int J Pharm 250:25-33. 2003
    ..We have demonstrated in our studies that these surface modified calcium phosphate nanoparticles can be used in vivo to target genes specifically to the liver...
  37. ncbi Effective transfection of cells with multi-shell calcium phosphate-DNA nanoparticles
    Viktoriya V Sokolova
    Institute of Inorganic Chemistry, University of Duisburg Essen, Universitaetsstrasse 5 7, D 45117 Essen, Germany
    Biomaterials 27:3147-53. 2006
    ..The dispersions were stable and could be used for transfection after 2 weeks of storage at 4 degrees C without loss of efficiency...
  38. pmc Lipid-coated nano-calcium-phosphate (LNCP) for gene delivery
    Chenguang Zhou
    Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Int J Pharm 392:201-8. 2010
    ....
  39. ncbi Transfection of adherent and suspended cells by calcium phosphate
    Martin Jordan
    LBTC, Laboratory of Cellular Biotechnology, EPFL, Lausanne Switzerland
    Methods 33:136-43. 2004
    ..Examples of protocols that were established and tested within the authors' laboratory are presented. The article also emphasizes differences between transfections of adherent and suspended cells...
  40. doi The importance of particle size and DNA condensation salt for calcium phosphate nanoparticle transfection
    Claudio E Pedraza
    Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
    Biomaterials 29:3384-92. 2008
    ..We found that the key parameters for effective calcium phosphate nanoparticle transfection were an optimal concentration of calcium and chloride ions and a nanosized non-agglomerated precipitate...
  41. ncbi Beta-TCP bone graft substitutes in a bilateral rabbit tibial defect model
    William R Walsh
    Surgical and Orthopaedic Research Laboratories, University of New South Wales, Prince of Wales Hospital, L1 Clinical Sciences Building, Sydney 2031, Australia
    Biomaterials 29:266-71. 2008
    ..Vitoss resorbed faster than the other materials and is likely to differences in particle geometry, pore structure and interconnectivity...
  42. doi Comparative in vivo study of six hydroxyapatite-based bone graft substitutes
    Pamela Habibovic
    University of Twente, Department of Tissue Regeneration, Enschede, The Netherlands
    J Orthop Res 26:1363-70. 2008
    ....
  43. pmc Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery
    Jun Li
    Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Control Release 142:416-21. 2010
    ..The untargeted NP showed a very low silencing effect. The new formulation improved the in vitro silencing effect 3-4 folds compared to the previous LPD formulation, but had a negligible immunotoxicity...
  44. ncbi Tissue-engineered bone using mesenchymal stem cells and a biodegradable scaffold
    Jae Seong Boo
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Nagoya University, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    J Craniofac Surg 13:231-9; discussion 240-3. 2002
    ..The fabricated synthetic bone using biodegradable beta-TCP as a scaffold in vivo is useful for reconstructing bone, because the scaffold material is absorbed several months after implantation...
  45. ncbi Repair of segmental bone defects in rabbit tibiae using a complex of beta-tricalcium phosphate, type I collagen, and fibroblast growth factor-2
    Hirokazu Komaki
    Department of Orthopaedic Surgery, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Tokyo, Japan
    Biomaterials 27:5118-26. 2006
    ..In addition, the complex of beta-TCP granules and collagen combined with rhFGF-2 provides a paste-like material that is easy to handle. This material may be of considerable use in the treatment of cortical bone defects...
  46. pmc Bone regeneration: molecular and cellular interactions with calcium phosphate ceramics
    Florence Barrere
    Biomedical Technological Institute BMTI, University ofTwente, Enschede, The Netherlands
    Int J Nanomedicine 1:317-32. 2006
    ....
  47. ncbi Synthetic bone graft substitutes
    W R Moore
    Department of Orthopaedic Surgery, Modbury Public Hospital, Modbury, Australia
    ANZ J Surg 71:354-61. 2001
    ..The benefits of synthetic grafts include availability, sterility and reduced morbidity. The present article examines the relevance of synthetic bone graft substitutes, their mechanical properties and clinical application...
  48. ncbi Repair of canine mandibular bone defects with bone marrow stromal cells and porous beta-tricalcium phosphate
    Jie Yuan
    Shanghai Key Laboratory of Tissue Engineering, Department of Plastic and Reconstructive Surgery, Shanghai 9th People s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhi Zao Ju Road, Shanghai 200011, China
    Biomaterials 28:1005-13. 2007
    ..05). Based on these results, we conclude that engineered bone from osteogenically induced BMSCs and biodegradable beta-TCP can well repair the critical-sized segmental mandibular defects in canines...
  49. doi The kinetic and biological activity of different loaded rhBMP-2 calcium phosphate cement implants in rats
    Esther W H Bodde
    Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Biomed Mater Res A 87:780-91. 2008
    ..Low amounts of sustained released rhBMP-2 were sufficient to bridge critically sized defects. A substantial amount of rhBMP-2 was retained in the implants because of the slow release rate and the limited degradation...
  50. ncbi Fibre reinforced bioresorbable composites for spinal surgery
    Mikko Huttunen
    Tampere University of Technology, Institute of Biomaterials, Hermiankatu 12 A, P O Box 589, FIN 33101 Tampere, Finland
    Acta Biomater 2:575-87. 2006
    ..The initial compressive strengths of the studied composites were comparable to materials used in spinal fusion applications, but adequate strength retention behaviour needs to be confirmed before undertaking clinical experiments...
  51. ncbi The effect of pH on the structural evolution of accelerated biomimetic apatite
    Yu Fen Chou
    Department of Bioengineering, UCLA, 7523 Boelter Hall, Los Angeles, CA 90095, USA
    Biomaterials 25:5323-31. 2004
    ..5) (pH 6.5) precursor spheres transform into larger, single crystals plates, SBF1(5.8) (pH 5.8) precursor spheres developed minute, polycrystalline plate-like structures over predominantly spherical precursor substrate...
  52. doi A biodegradable porous composite scaffold of PGA/beta-TCP for bone tissue engineering
    Hong Cao
    Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo, Japan
    Bone 46:386-95. 2010
    ..Thus the PGA/beta-TCP composite scaffold, especially weight ratio 1:3, exhibited a strong ability for osteogenesis, mineralization and biodegradation for bone replacement...
  53. ncbi Tissue-engineered bone formation using human bone marrow stromal cells and novel beta-tricalcium phosphate
    Guangpeng Liu
    National Tissue Engineering Research and Development Center, Shanghai 200235, People s Republic of China
    Biomed Mater 2:78-86. 2007
    ..The above findings illustrate that the novel porous beta-TCP scaffolds developed in this work have prominent osteoconductive activity and the potential for applications in bone tissue engineering...
  54. ncbi Injectability of calcium phosphate pastes
    Marc Bohner
    Dr H C Robert Mathys Foundation, Bischmattstrasse 12, CH 2544 Bettlach, Switzerland
    Biomaterials 26:1553-63. 2005
    ..This effect could be due to a change of the PL of the powder or to the lubricating effect of the polymer...
  55. ncbi Biological performance of a new beta-TCP/PLLA composite material for applications in spine surgery: in vitro and in vivo studies
    Stephane Aunoble
    Bordeaux 2 University, Spine Unit, 6th Floor, DETERCA Lab, 146 Leo Saignat, Bordeaux 33076, France
    J Biomed Mater Res A 78:416-22. 2006
    ....
  56. ncbi Bone formation and degradation of a highly porous biphasic calcium phosphate ceramic in presence of BMP-7, VEGF and mesenchymal stem cells in an ectopic mouse model
    J C Roldán
    Department of Cranio Maxillofacial Surgery, University of Regensburg, Regensburg, Germany
    J Craniomaxillofac Surg 38:423-30. 2010
    ....
  57. ncbi Polymer--calcium phosphate cement composites for bone substitutes
    Rafal A Mickiewicz
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
    J Biomed Mater Res 61:581-92. 2002
    ..The increased strength was attributed to the polymer's capacity to bridge between multiple crystallites (thus forming a more cohesive composite) and to absorb energy through plastic flow...
  58. ncbi Bone repair in radii and tibias of rabbits with phosphorylated chitosan reinforced calcium phosphate cements
    Xiaohong Wang
    State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, People s Republic of China
    Biomaterials 23:4167-76. 2002
    ..Progressive substitution took place at the interface of implants and host bones. No adverse effects were found in tissues around the bone defects. Thus, they could be used as bone substitutes in clinic...
  59. ncbi A preliminary study on osteoinduction of two kinds of calcium phosphate ceramics
    H Yuan
    Institute of Materials Science and Technology, Sichuan Union University, Chengdu, People s Republic of China
    Biomaterials 20:1799-806. 1999
    ..These data suggest that, by controlling the preparation of calcium phosphate ceramic, bone substitutes with intrinsic osteoinductive property can be developed from calcium phosphates.
  60. ncbi Osteogenesis and angiogenesis of tissue-engineered bone constructed by prevascularized β-tricalcium phosphate scaffold and mesenchymal stem cells
    Le Wang
    Institute of Orthopaedics and Traumatology, The Third Affiliated Hospital, Guangzhou Medical University, People s Republic of China
    Biomaterials 31:9452-61. 2010
    ....
  61. ncbi Material-dependent bone induction by calcium phosphate ceramics: a 2.5-year study in dog
    H Yuan
    Institute of Materials Science and Technology, Sichuan University, Chengdu, China
    Biomaterials 22:2617-23. 2001
    ..Although the quality and quantity varied among different ceramics, the induced bone in both HA and BCP ceramics did neither disappear nor grow uncontrollably during the period as long as 2.5 years...
  62. ncbi Promotion of bone formation using highly pure porous beta-TCP combined with bone marrow-derived osteoprogenitor cells
    Jian Dong
    Tissue Engineering Research Center, National Institute of Advanced Industrial Science and Technology, Ibaraki, Japan
    Biomaterials 23:4493-502. 2002
    ..These results showed that tissue engineering treatment on incubating the composites of beta-TCP and BMO cells in osteogenic medium results in a good osteogenic activity...
  63. doi Calcium phosphate/poly(D,L-lactic-co-glycolic acid) composite bone substitute materials: evaluation of temporal degradation and bone ingrowth in a rat critical-sized cranial defect
    Floor C J van de Watering
    Department of Biomaterials 309, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Clin Oral Implants Res 23:151-9. 2012
    ....
  64. ncbi Histological and mechanical evaluation of self-setting calcium phosphate cements in a sheep vertebral bone void model
    Naomi Kobayashi
    Department of Anatomic Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Biomed Mater Res A 81:838-46. 2007
    ..The barium sulfate did not affect the CPCs biocompatibility or mechanical properties. These results suggest that CPC might be a good alternative to polymethylmethacrylate for selected indications...
  65. ncbi Phosphate: a stealthier killer than previously thought?
    Emilio Gonzalez-Parra
    Nephrology Department, IIS Fundación Jiménez Díaz, Universidad Autonoma de Madrid, Madrid
    Cardiovasc Pathol 21:372-81. 2012
    ....
  66. ncbi Calcium fortification systems differ in bioavailability
    Robert P Heaney
    Creighton University Medical Center, 601 N 30th Street, Omaha, NE 68131, USA
    J Am Diet Assoc 105:807-9. 2005
    ..Nutritionists and dietetics professionals should encourage manufacturers of fortified products to provide information on bioavailability...
  67. ncbi Relevance of osteoinductive biomaterials in critical-sized orthotopic defect
    Pamela Habibovic
    University of Twente, Institute for Biomedical Technology, Professor Bronkhorstlaan 10D, 3723 MB Blithoven, The Netherlands
    J Orthop Res 24:867-76. 2006
    ..Further improvement of material osteoinductive properties is thus a significant step forward in the search for alternatives for autologous bone graft...
  68. doi Evaluation of the ultrasonication process for injectability of hydraulic calcium phosphate pastes
    Mohamed Habib
    Laboratoire de Biomecanique, Département de Génie, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1K 2R1
    Acta Biomater 8:1164-8. 2012
    ..4 ± 2.3% without ultrasonication to 97.3 ± 2.4% with 30%. This result shows that ultrasonication is an effective solution to improve injectability...
  69. doi Repair of bone defect in caprine tibia using a laminated scaffold with bone marrow stromal cells loaded poly (L-lactic acid)/β-tricalcium phosphate
    Jianyan Huang
    Biomedical Engineering Institute of Jinan University, Guangzhou, China
    Artif Organs 35:49-57. 2011
    ..X-ray examinations and histological analyses showed new bone tissues formed with similar structures to normal ones. It is suggested that the novel PLLA/β-TCP laminated scaffold with BMSCs loading can regenerate new bones quickly...
  70. ncbi Percutaneous vertebroplasty for osteoporotic compression fractures using calcium phosphate cement
    Shigeo Ishiguro
    Department of Orthopaedic Surgery, Oyamada Memorial Spa Hospital, Yokkaichi, Mie, Japan
    J Orthop Surg (Hong Kong) 18:346-51. 2010
    ..To compare percutaneous transpedicular vertebroplasty using calcium phosphate cement (CPC) versus conservative treatment for osteoporotic vertebral fractures...
  71. ncbi Use of calcium phosphate cement scaffolds for bone tissue engineering: in vitro study
    Taís Somacal Novaes Silva
    Department of Oral and Maxillofacial Surgery, PUCRS, Porto Alegre, RS, Brazil
    Acta Cir Bras 26:7-11. 2011
    ..To evaluate the ability of macroporous tricalcium phosphate cement (CPC) scaffolds to enable the adhesion, proliferation, and differentiation of mesenchymal stem cells derived from human bone marrow...
  72. ncbi Tracking the pathway of calcium phosphate/DNA nanoparticles during cell transfection by incorporation of red-fluorescing tetramethylrhodamine isothiocyanate-bovine serum albumin into these nanoparticles
    Viktoriya Sokolova
    Institute of Inorganic Chemistry, University of Duisburg Essen, Universitaetsstrasse 5 7, 45117, Essen, Germany
    J Biol Inorg Chem 12:174-9. 2007
    ..Aggregates of DNA/TRITC-BSA alone were not able to enter the cells, i.e., the inorganic nanoparticles are necessary as a carrier through the cell membrane...
  73. ncbi Trabecular bone response to injectable calcium phosphate (Ca-P) cement
    E M Ooms
    Department of Biomaterials, College of Dental Science, University Medical Center Nijmegen, P O Box 9101, 6500 HB, The Netherlands
    J Biomed Mater Res 61:9-18. 2002
    ..The results indicate that the investigated Ca-P cement is biocompatible, osteoconductive, as well as osteotransductive and is a candidate material for use as a bone substitute...
  74. ncbi Influence of gender and age on calcium oxalate crystal growth inhibition by urine from relatives of stone forming patients
    Kristin J Bergsland
    University of Chicago and LithoLink Corp, Chicago, Illinois, USA
    J Urol 167:2372-6. 2002
    ..We define the relationships between urine inhibition of calcium oxalate crystal growth and age, gender, urine chemistries and stone formation among relatives of calcium stone forming patients...
  75. doi Effect of PEG amount in amorphous calcium phosphate on its crystallized products
    Siqian Liu
    Department of Materials Science and Engineering, Zhejiang University, Hangzhou, 310027, China
    J Mater Sci Mater Med 20:359-63. 2009
    ..One reason for the influence of PEG is that ACP with different PEG content could have two types of unit structures that tend to form alpha-TCP and beta-TCP after crystallization...
  76. ncbi Prebiotic formation of ADP and ATP from AMP, calcium phosphates and cyanate in aqueous solution
    Y Yamagata
    Laboratory of Chemical Evolution, Ishikawa, Japan
    Orig Life Evol Biosph 29:511-20. 1999
    ..The other nucleoside-5'-triphosphates were also produced from their respective diphosphates...
  77. ncbi Acute effect of high-calcium milk with or without additional magnesium, or calcium phosphate on parathyroid hormone and biochemical markers of bone resorption
    J H Green
    Milk and Health Research Centre, Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand
    Eur J Clin Nutr 57:61-8. 2003
    ....
  78. doi Biomimetic calcium phosphate coatings as bone morphogenetic protein delivery systems in spinal fusion
    Kamran Majid
    Department of Orthopaedic Surgery, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Spine J 11:560-7. 2011
    ..It is hypothesized that incorporation of rhBMP-2 within a calcium phosphate (CaP) coating may help to localize delivery and mitigate these complications...
  79. doi Strontium substitution in bioactive calcium phosphates: a first-principles study
    Katsuyuki Matsunaga
    Department of Materials Science and Engineering, Kyoto University, Kyoto, Japan
    J Phys Chem B 113:3584-9. 2009
    ..It is thought, therefore, that Sr(2+) plays its role to promote bone formation by being incorporated into the metastable OCP phase occurring during HAp nucleation...
  80. ncbi Chemical, modulus and cell attachment studies of reactive calcium phosphate filler-containing fast photo-curing, surface-degrading, polymeric bone adhesives
    E A Abou Neel
    UCL, Eastman Dental Institute, London, UK
    Acta Biomater 6:2695-703. 2010
    ..reactive calcium phosphates (monocalcium phosphate monohydrate (MCPM)/beta-tricalcium phosphate (beta-TCP)) have been assessed using ..
  81. doi The correlation between the internal structure and vascularization of controllable porous bioceramic materials in vivo: a quantitative study
    Feng Bai
    Department of Orthopaedics of XiJing Hospital, Fourth Military Medical University, Xi an, P R China
    Tissue Eng Part A 16:3791-803. 2010
    ....
  82. doi Ectopic bone formation in adipose-derived stromal cell-seeded osteoinductive calcium phosphate scaffolds
    Jinfeng Yao
    State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, 610044, P R China
    J Biomater Appl 24:607-24. 2010
    ..The ADSCs had a significantly positive effect on the ectopic bone formation. In addition, the usefulness of Micro-CT for the efficient and nondestructive analysis of mineralized bone and calcium phosphate scaffold was confirmed...
  83. doi The effect of powder properties on sintering, microstructure, mechanical strength and degradability of beta-tricalcium phosphate/calcium silicate composite bioceramics
    Kaili Lin
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People s Republic of China
    Biomed Mater 4:065009. 2009
    ..Furthermore, the degradability of the samples fabricated from TW-B powders was obviously lower than that of the samples fabricated from TW-A and TW-C powders...
  84. doi Reactive calcium-phosphate-containing poly(ester-co-ether) methacrylate bone adhesives: chemical, mechanical and biological considerations
    Xin Zhao
    Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, 256 Gray s Inn Road, London WC1X 8LD, UK
    Acta Biomater 6:845-55. 2010
    ..The above results suggest that the new composite materials hold promise as clinical effective bone adhesives...
  85. ncbi Effect of surface chemistry on the rate of osseointegration of sintered porous-surfaced Ti-6Al-4V implants
    Alex Tache
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Ontario, Canada
    Int J Oral Maxillofac Implants 19:19-29. 2004
    ..The effect of adding a thin sol-gel-formed calcium phosphate (CaP) coating to sintered porous-surfaced titanium alloy (Ti-6Al-4V) implants on rates of initial bone ingrowth was investigated...
  86. ncbi Integrin-supported fast rate intracellular delivery of plasmid DNA by extracellular matrix protein embedded calcium phosphate complexes
    E H Chowdhury
    Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    Biochemistry 44:12273-8. 2005
    ....
  87. ncbi Calcium phosphates as bone graft extenders
    Evalina L Burger
    University of Colorado Health Sciences Spine Center, Aurora, Colorado 80045, USA
    Orthopedics 30:939-42. 2007
    ..Thus, this article presents a comparative analysis of the physiochemical attributes of calcium phosphate materials used in spine surgery...
  88. ncbi Amorphous calcium phosphates: synthesis, properties and uses in biomaterials
    C Combes
    Universite de Toulouse, CIRIMAT, UPS INPT CNRS, ENSIACET, 4 allée Emile Monso, BP 44362, 31432 Toulouse Cedex 4, France
    Acta Biomater 6:3362-78. 2010
    This review paper on amorphous calcium phosphates (ACPs) provides an update on several aspects of these compounds which have led to many studies and some controversy since the 1970s, particularly because of the lack of irrefutable proof ..
  89. ncbi The use of hydroxyapatite and autogenous cancellous bone grafts to repair bone defects in rats
    R V Silva
    Department of Anatomy, Institute of Biology, State University of Campinas, Campinas, Sao Paulo, Brazil
    Int J Oral Maxillofac Surg 34:178-84. 2005
    ..These results indicated that the osteointegration of bioceramic fragments allowed the reconstruction of parietal bone defects without the need for a bone graft...
  90. doi In vivo bone response and mechanical evaluation of electrosprayed CaP nanoparticle coatings using the iliac crest of goats as an implantation model
    Corinne Schouten
    Department of Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Acta Biomater 6:2227-36. 2010
    ....
  91. ncbi Transfer of high copy number plasmid into mammalian cells by calcium phosphate transfection
    P Batard
    Swiss Federal Institute of Technology Lausanne, Center of Biotechnology CBUE, Department of Chemistry, 1015, Lausanne, Switzerland
    Gene 270:61-8. 2001
    ..While cells with maximal DNA load appear to express the highest level of the transgene, these cells are negatively impacted in terms of growth and survival...
  92. ncbi Modification of gene expression induced in human osteogenic and osteosarcoma cells by culture on a biphasic calcium phosphate bone substitute
    N Rochet
    INSERM U364, IFR50, Faculte de Medecine, Avenue de Valombrose, 06107 Nice Cedex 02, France
    Bone 32:602-10. 2003
    ..Owing to the nature and spatial organization of the BCP, our hypothesis is that culture on BCP is closer to the physiological situation than culture on plastic...
  93. ncbi Surface modification of tricalcium phosphate for improvement of the interfacial compatibility with biodegradable polymers
    Carmen Kunze
    Institute of Materials Sciences, Polymer Engineering, Martin Luther University Halle Wittenberg, D 06099 Halle Saale, Germany
    Biomaterials 24:967-74. 2003
    ..Chemical bonds between filler and polymer matrix are assumed to be formed by transesterification reactions...
  94. ncbi Spontaneous growth of a laminin-apatite nano-composite in a metastable calcium phosphate solution
    Ayako Oyane
    Nanotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, Central 5, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8565, Japan
    Biomaterials 27:167-75. 2006
    ..solution was stable for periods as long as 24 h; it did not induce homogeneous precipitation of laminin or calcium phosphates in the solution...
  95. ncbi Improved bone ingrowth and fixation with a thin calcium phosphate coating intended for complete resorption
    O Reigstad
    Orthopaedic Department, Rikshospitalet National Hospital, 0027 Oslo, Norway
    J Biomed Mater Res B Appl Biomater 83:9-15. 2007
    ..This unloaded short-term study has shown promising results for the easily applicable and resorbable coat (Bonit) compared to uncoated titanium-alloy implants...
  96. ncbi A poly(lactic acid)/calcium metaphosphate composite for bone tissue engineering
    Youngmee Jung
    Biomaterials Research Center, Korea Institute of Science and Technology, P O BOX 131, Cheongryang, Seoul 130 650, Korea
    Biomaterials 26:6314-22. 2005
    ..As the novel sintering method does not use any solvents it offers another advantage to avoid problems associated with solvent residue...
  97. ncbi In vitro synthesis and characterization of amorphous calcium phosphates with various Ca/P atomic ratios
    Yanbao Li
    Department of Materials of Science and Engineering, Zhejiang University, Hangzhou 310027, PR China
    J Mater Sci Mater Med 18:2303-8. 2007
    Amorphous calcium phosphates (ACP) were synthesized utilizing poly(ethylene glycol) as stabilizing additive at low temperature...
  98. ncbi Physicochemical evaluation of bioactive polymeric composites based on hybrid amorphous calcium phosphates
    D Skrtic
    American Dental Association Health Foundation Paffenbarger Research Center, National Institute of Standards and Technology, Gaithersburg, MD 20899 8546, USA
    J Biomed Mater Res 53:381-91. 2000
    ..Therefore, hybridized ACP-filled BTHZ composites have a potential for utilization in more demanding restorative, sealant, and adhesive applications...
  99. ncbi Electrochemical processes of nucleation and growth of calcium phosphate on titanium supported by real-time quartz crystal microbalance measurements and X-ray photoelectron spectroscopy analysis
    Noam Eliaz
    Biomaterials and Corrosion Laboratory, School of Mechanical Engineering, Tel Aviv University, Ramat Aviv 69978, Israel
    J Biomed Mater Res A 89:270-80. 2009
    ..crystal microbalance (EQCM) measurements are conducted to better understand the electrocrystallization of calcium phosphates (CaP) on CP-Ti...
  100. ncbi Controlled synthesis of plate-shaped hydroxyapatite and implications for the morphology of the apatite phase in bone
    B Viswanath
    Materials Research Centre, Indian Institute of Science, Bangalore 560 012, India
    Biomaterials 29:4855-63. 2008
    ..The synthesis and analysis presented here have important implications for understanding the plate-shaped morphology of apatite crystals that exist in the bone...
  101. ncbi Performance of hydroxyapatite bone repair scaffolds created via three-dimensional fabrication techniques
    Tithi Dutta Roy
    Departtment of Orthopaedics, UMDNJ New Jersey Medical School, 185 South Orange Avenue, MSB G 574, Newark, New Jersey 07103, USA
    J Biomed Mater Res A 67:1228-37. 2003
    ..Therefore, the current study indicates that scaffold geometry, as determined by the fabrication process, can enhance the ability of a ceramic material to accelerate healing of calvarial defects...

Research Grants66

  1. PROTEIN INHIBITORS OF CALCIUM PHOSPHATE PRECIPITATION
    David Schlesinger; Fiscal Year: 1990
    ..However, precipitation of these salts from saliva and crystal growth of calcium phosphates onto dental enamel do not occur under normal physiological conditions...
  2. MAGNESIUM AND FORMATION/STABILITY OF CALCIUM PHOSPHATES
    Racquel LeGeros; Fiscal Year: 1991
    ..Ca-P phases: ACMP, Mg-substituted amorphous calcium phosphate; DCPD, dicalcium phosphate dihydrate; OCP, octacalcium phosphate; b-TCMP, Mg-substituted whitlockite; AP, non-stoichiometric apatite]...
  3. NORMAL & PATHOLOGICAL ENAMEL MINERALIZATION
    Takaaki Aoba; Fiscal Year: 1990
    ..results, we will re-evaluate the degree of saturation of enamel fluid with respect to enamel and other calcium phosphates of interest...
  4. KINETICS OF MINERALIZATION OF TEETH
    GEORGE NANCOLLAS; Fiscal Year: 1990
    ..Electrophoretic mobilities of enamel, dentin, calculus, and synthetic calcium phosphates will be determined in the presence of both simple inorganic ions and salivary proteins...
  5. POLYURETHANE CALCIFICATION, MECHANISM AND INHIBITION
    Robert Levy; Fiscal Year: 1999
    ..part to the propensity of this material to provide an appropriate nucleating and crystal growth surface for calcium phosphates; 2) We hypothesize that the predominantly surface oriented polyurethane calcification is due to adsorption ..
  6. POLYURETHANE CALCIFICATION, MECHANISM AND INHIBITION
    Robert Levy; Fiscal Year: 2000
    ..part to the propensity of this material to provide an appropriate nucleating and crystal growth surface for calcium phosphates; 2) We hypothesize that the predominantly surface oriented polyurethane calcification is due to adsorption ..
  7. GORDON RESEARCH CONFERENCE ON CALCIUM PHOSPHATES, 1992
    ROY WUTHIER; Fiscal Year: 1992
    This proposal is submitted to help organize and conduct the 1992 Gordon Research Conference on Calcium Phosphates, to be held July 20 to 24 at Salve Regina College, Newport, Rhode Island...
  8. THREE APPROACHES TO RAPID REMINERALIZATION OF THE TOOTH
    Ming Tung; Fiscal Year: 1990
    ..stability of calcium phosphate solution; (2) determine factors affecting the precipitation and maturation of calcium phosphates in the above three kind of solutions: (3) formulate solutions based on the above findings; and (4) test in ..
  9. 2004-2006 Biomineralization Gordon Research Conferences
    Joanna Aizenberg; Fiscal Year: 2006
    ..the Conference include: the structure of the mineral in organs of vertebrates and invertebrates, including calcium phosphates, carbonates, and silica; the properties and function of the matrix proteins found in mineralized tissues; ..
  10. THE KINETICS OF MINERALIZATION OF TEETH
    GEORGE NANCOLLAS; Fiscal Year: 1991
    ..Aggregation and electrophoretic mobility measurements of dentin, calculus, enamel, and synthetic calcium phosphates will be determined in the presence of both simple inorganic ions and separated salivary proteins.
  11. KINETICS OF MINERALIZATION OF TEETH
    GEORGE NANCOLLAS; Fiscal Year: 2000
    ..Aggregation and electrophoretic mobility measurements of dentin, calculus, enamel, and synthetic calcium phosphates will be determined in the presence of both simple inorganic ions and separated salivary proteins.
  12. GORDON RESEARCH CONFERENCE ON BIOMINERALIZATION
    STEPHEN WEINER; Fiscal Year: 2001
    ..This meeting is a continuation of the Gordon Research Conference on Calcium Phosphates (previously held on alternate years since 1979), organized in a new direction...
  13. GORDON RESEARCH CONFERENCE ON BIOMINERALIZATION
    Malcolm Snead; Fiscal Year: 2000
    ..This meeting is a continuation of the Gordon Research Conference on Calcium Phosphates (previously held on alternate years since 1979), organized in a new direction...
  14. 2004-2006 Biomineralization Gordon Research Conferences
    Fred Wilt; Fiscal Year: 2005
    ..the Conference include: the structure of the mineral in organs of vertebrates and invertebrates, including calcium phosphates, carbonates, and silica; the properties and function of the matrix proteins found in mineralized tissues; ..
  15. THE KINETICS OF FORMATION OF RENAL STONES
    GEORGE NANCOLLAS; Fiscal Year: 1980
    ..and dissolution of synthetic renal stone-forming minerals such as calcium oxalate, uric acid, the urates, calcium phosphates and magnesium ammonium phosphate in supersaturated solutions and in urine...
  16. KINETICS OF MINERALIZATION OF TEETH
    GEORGE NANCOLLAS; Fiscal Year: 1999
    ..Aggregation and electrophoretic mobility measurements of dentin, calculus, enamel, and synthetic calcium phosphates will be determined in the presence of both simple inorganic ions and separated salivary proteins.
  17. 2004-2006 Biomineralization Gordon Research Conferences
    Fred Wilt; Fiscal Year: 2004
    ..the Conference include: the structure of the mineral in organs of vertebrates and invertebrates, including calcium phosphates, carbonates, and silica; the properties and function of the matrix proteins found in mineralized tissues; ..
  18. Functionalizing Hydroxyapatite With Proadhesive Peptides
    Susan Bellis; Fiscal Year: 2007
    ..of materials, however, surprisingly, the class of materials that is among the most osseoconductive, the calcium phosphates, has received the least amount of attention in this regard...
  19. Functionalizing Hydroxyapatite With Proadhesive Peptides
    Susan Bellis; Fiscal Year: 2006
    ..of materials, however, surprisingly, the class of materials that is among the most osseoconductive, the calcium phosphates, has received the least amount of attention in this regard...
  20. CHEMISTRY OF CALCIUM PHOSPHATES
    Walter Brown; Fiscal Year: 1980
    ..Crystal Chemistry of Calcium Phosphates: Emphasis is on the chemistry of octacalcium phosphate and how it participates in the formation of hard-..
  21. Functionalizing Hydroxyapatite With Proadhesive Peptides
    Susan Bellis; Fiscal Year: 2005
    ..of materials, however, surprisingly, the class of materials that is among the most osseoconductive, the calcium phosphates, has received the least amount of attention in this regard...
  22. AMORPHOUS CALCIUM PHOSPHATE BASED DENTAL MATERIALS
    Drago Skrtic; Fiscal Year: 2001
    ..formation of hydroxyapatite (HAP), has received less attention as a dental material than crystalline calcium phosphates (CaPs)...
  23. AMORPHOUS CALCIUM PHOSPHATE BASED DENTAL MATERIALS
    Drago Skrtic; Fiscal Year: 2002
    ..formation of hydroxyapatite (HAP), has received less attention as a dental material than crystalline calcium phosphates (CaPs)...
  24. AMORPHOUS CALCIUM PHOSPHATE BASED DENTAL MATERIALS
    Drago Skrtic; Fiscal Year: 2003
    ..formation of hydroxyapatite (HAP), has received less attention as a dental material than crystalline calcium phosphates (CaPs)...
  25. AMORPHOUS CALCIUM PHOSPHATE BASED DENTAL MATERIALS
    Drago Skrtic; Fiscal Year: 2000
    ..formation of hydroxyapatite (HAP), has received less attention as a dental material than crystalline calcium phosphates (CaPs)...
  26. Solid State NMR Structure/Function Studies of Amelogenin
    WENDY SHAW; Fiscal Year: 2005
    ..secondary structure, dynamics and amino acids important in binding the protein or protein self assembly to calcium phosphates. QCM will be used to investigate nucleation rates and protein binding kinetics...
  27. Solid State NMR Structure/Function Studies of Amelogenin
    WENDY SHAW; Fiscal Year: 2007
    ..secondary structure, dynamics and amino acids important in binding the protein or protein self assembly to calcium phosphates. QCM will be used to investigate nucleation rates and protein binding kinetics...
  28. Solid State NMR Structure/Function Studies of Amelogenin
    WENDY SHAW; Fiscal Year: 2006
    ..secondary structure, dynamics and amino acids important in binding the protein or protein self assembly to calcium phosphates. QCM will be used to investigate nucleation rates and protein binding kinetics...
  29. THE KINETICS OF MINERALIZATION OF TEETH
    GEORGE NANCOLLAS; Fiscal Year: 2002
    ..biominerals, we will make surface tension measurements by sessile drop and thin layer wicking on synthetic calcium phosphates and enamel and dentin surfaces both in the absence and presence of modulating additives...
  30. THE KINETICS OF MINERALIZATION OF TEETH
    GEORGE NANCOLLAS; Fiscal Year: 2004
    ..biominerals, we will make surface tension measurements by sessile drop and thin layer wicking on synthetic calcium phosphates and enamel and dentin surfaces both in the absence and presence of modulating additives...
  31. THE KINETICS OF MINERALIZATION OF TEETH
    GEORGE NANCOLLAS; Fiscal Year: 2006
    ..biominerals, we will make surface tension measurements by sessile drop and thin layer wicking on synthetic calcium phosphates and enamel and dentin surfaces both in the absence and presence of modulating additives...
  32. THE KINETICS OF MINERALIZATION OF TEETH
    GEORGE NANCOLLAS; Fiscal Year: 2005
    ..biominerals, we will make surface tension measurements by sessile drop and thin layer wicking on synthetic calcium phosphates and enamel and dentin surfaces both in the absence and presence of modulating additives...
  33. THE KINETICS OF MINERALIZATION OF TEETH
    GEORGE NANCOLLAS; Fiscal Year: 2003
    ..biominerals, we will make surface tension measurements by sessile drop and thin layer wicking on synthetic calcium phosphates and enamel and dentin surfaces both in the absence and presence of modulating additives...
  34. GENOME SEQUENCE OF STREPTOCOCCUS SOBRINUS
    Steven Gill; Fiscal Year: 2001
    ..As acid production is important to the release of calcium phosphates from the tooth enamel, and the subsequent formation of caries, this unique ability of S...
  35. TRANSPORT IN ENAMEL AND SOLUBILITY OF ENAMEL
    EDGARD MORENO; Fiscal Year: 1991
    ..supersaturation that the plaque fluid can reach with respect to the enamel mineral or with respect to basic calcium phosphates that can be incorporated within the enamel structure; this situation is expected to be modulated by the ..
  36. MATRIX PROTEIN CONTROL OF CRYSTAL NUCLEATION AND GROWTH
    HENRY MARGOLIS; Fiscal Year: 2000
    ..g. amelogenin aggregates) provide the appropriate surface characteristics to induce the nucleation of calcium phosphates. In the presence of appropriate concentrations of mineral ions, this results in the formation of very thin ..
  37. CRYSTAL CHEMISTRY OF CALCIUM PHOSPHATES
    MATHAI MATHEW; Fiscal Year: 1990
    ..The setting reactions and compressive and diametral tensile strengths of CPC will be correlated with the crystallinity and particle size distribution of the cement ingredients...
  38. HYDROXYAPATITE-BASED DENTAL RESTORATIVE MATERIALS
    Paul Brown; Fiscal Year: 1993
    ..The basis for the approach is that basic and acidic calcium phosphates react in aqueous solution at low temperature to form HAp...
  39. CALCIUM PHOSPHATE COATING FOR ORTHOPEDIC PROSTHESES
    Myron Spector; Fiscal Year: 1993
    ..They expect that this apatite deposition and subsequent bone bonding proceeds at a slower rate than with calcium phosphates more closely resembling bone mineral...
  40. CALCIUM PHOSPHATE COATING FOR ORTHOPEDIC PROSTHESES
    Myron Spector; Fiscal Year: 1991
    ..They expect that this apatite deposition and subsequent bone bonding proceeds at a slower rate than with calcium phosphates more closely resembling bone mineral...
  41. Novel DNA Delivery via Surface Bound Calcium Phosphates
    Jian Tan; Fiscal Year: 2007
    ..The technology developed in this proposal will have important impact on basic research, biotech industry and gene therapy based medicine. [unreadable] [unreadable] [unreadable]..
  42. THE KINETICS OF MINERALIZATION OF TEETH
    GEORGE NANCOLLAS; Fiscal Year: 1980
    The overall objective of the proposed research is the characterization of the kinetics of mineralization of calcium phosphates and the inorganic and organic components of teeth such as whole and carious enamel and dentine, predentine, ..
  43. MATRIX PROTEIN CONTROL OF CRYSTAL NUCLEATION AND GROWTH
    HENRY MARGOLIS; Fiscal Year: 2001
    ..g. amelogenin aggregates) provide the appropriate surface characteristics to induce the nucleation of calcium phosphates. In the presence of appropriate concentrations of mineral ions, this results in the formation of very thin ..
  44. NANOSTRUCTURED BIOACTIVE MATERIALS
    Laurence Chow; Fiscal Year: 2007
    ..unreadable] [unreadable] Aim 3 will evaluate the effectiveness of nano sized calcium phosphates and calcium fluoride in reducing dentin permeability, a property closely associated with dental ..
  45. CARIOGENIC POTENTIAL OF DENTAL PLAQUE FLUID
    HENRY MARGOLIS; Fiscal Year: 1991
    ..This approach will provide a unified picture of the caries process and may ultimately be useful in the design of anti-caries procedures and in the assessment of patient risk...
  46. NANOSTRUCTURED BIOACTIVE MATERIALS
    Laurence Chow; Fiscal Year: 2006
    ..unreadable] [unreadable] Aim 3 will evaluate the effectiveness of nano sized calcium phosphates and calcium fluoride in reducing dentin permeability, a property closely associated with dental ..
  47. NANOSTRUCTURED BIOACTIVE MATERIALS
    Laurence Chow; Fiscal Year: 2009
    ..Aim 3 will evaluate the effectiveness of nano sized calcium phosphates and calcium fluoride in reducing dentin permeability, a property closely associated with dental ..