calcium phosphates

Summary

Summary: Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements.

Top Publications

  1. ncbi Nanostructured calcium phosphates for biomedical applications: novel synthesis and characterization
    Prashant N Kumta
    Department of Materials Science and Engineering, Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Acta Biomater 1:65-83. 2005
  2. ncbi Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth
    O Gauthier
    Laboratoire de Chirurgie, Ecole Nationale Veterinaire de Nantes, France
    Biomaterials 19:133-9. 1998
  3. ncbi Nanostructured calcium phosphates (NanoCaPs) for non-viral gene delivery: influence of the synthesis parameters on transfection efficiency
    Dana Olton
    Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Biomaterials 28:1267-79. 2007
  4. ncbi Effective transfection of cells with multi-shell calcium phosphate-DNA nanoparticles
    Viktoriya V Sokolova
    Institute of Inorganic Chemistry, University of Duisburg-Essen, Universitaetsstrasse 5-7, D-45117 Essen, Germany
    Biomaterials 27:3147-53. 2006
  5. ncbi Tissue-engineered bone using mesenchymal stem cells and a biodegradable scaffold
    Jae Seong Boo
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Nagoya University, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    J Craniofac Surg 13:231-9; discussion 240-3. 2002
  6. ncbi Comparative in vivo study of six hydroxyapatite-based bone graft substitutes
    Pamela Habibovic
    University of Twente, Department of Tissue Regeneration, Enschede, The Netherlands
    J Orthop Res 26:1363-70. 2008
  7. ncbi The importance of particle size and DNA condensation salt for calcium phosphate nanoparticle transfection
    Claudio E Pedraza
    Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
    Biomaterials 29:3384-92. 2008
  8. ncbi Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery
    Jun Li
    Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Control Release 142:416-21. 2010
  9. ncbi Calcium phosphate nanoparticles as novel non-viral vectors for targeted gene delivery
    Indrajit Roy
    Department of Chemistry, University of Delhi, Delhi 110007, India
    Int J Pharm 250:25-33. 2003
  10. ncbi Calcium phosphate nanoparticles as a novel nonviral vector for efficient transfection of DNA in cancer gene therapy
    Ting Liu
    Xiangya Hospital, Central South University, Changsha 410078, Hunan Province, People's Republic of China
    Cancer Biother Radiopharm 20:141-9. 2005

Research Grants

  1. KINETICS OF MINERALIZATION OF TEETH
    GEORGE NANCOLLAS; Fiscal Year: 1990
  2. POLYURETHANE CALCIFICATION, MECHANISM AND INHIBITION
    Robert Levy; Fiscal Year: 2000
  3. 2004-2006 Biomineralization Gordon Research Conferences
    Joanna Aizenberg; Fiscal Year: 2006
  4. Functionalizing Hydroxyapatite With Proadhesive Peptides
    Susan Bellis; Fiscal Year: 2007
  5. AMORPHOUS CALCIUM PHOSPHATE BASED DENTAL MATERIALS
    Drago Skrtic; Fiscal Year: 2003
  6. Solid State NMR Structure/Function Studies of Amelogenin
    WENDY SHAW; Fiscal Year: 2007
  7. THE KINETICS OF MINERALIZATION OF TEETH
    GEORGE NANCOLLAS; Fiscal Year: 2006
  8. THE KINETICS OF MINERALIZATION OF TEETH
    GEORGE NANCOLLAS; Fiscal Year: 1980
  9. Novel DNA Delivery via Surface Bound Calcium Phosphates
    Jian Tan; Fiscal Year: 2007
  10. NANOSTRUCTURED BIOACTIVE MATERIALS
    Laurence Chow; Fiscal Year: 2007

Detail Information

Publications245 found, 100 shown here

  1. ncbi Nanostructured calcium phosphates for biomedical applications: novel synthesis and characterization
    Prashant N Kumta
    Department of Materials Science and Engineering, Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Acta Biomater 1:65-83. 2005
    ..This paper illustrates our approach to implement calcium phosphates as gene delivery agents...
  2. ncbi Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth
    O Gauthier
    Laboratoire de Chirurgie, Ecole Nationale Veterinaire de Nantes, France
    Biomaterials 19:133-9. 1998
    ..MBCP implants with 565 microm pore diameter and 40% macroporosity represented the optimal association for homogeneous and abundant bone ingrowth...
  3. ncbi Nanostructured calcium phosphates (NanoCaPs) for non-viral gene delivery: influence of the synthesis parameters on transfection efficiency
    Dana Olton
    Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Biomaterials 28:1267-79. 2007
    ..In addition, X-ray diffraction and Fourier transform infrared spectroscopy analyses confirmed that all of the synthesized CaP structures exhibited the hydroxyapatite phase...
  4. ncbi Effective transfection of cells with multi-shell calcium phosphate-DNA nanoparticles
    Viktoriya V Sokolova
    Institute of Inorganic Chemistry, University of Duisburg-Essen, Universitaetsstrasse 5-7, D-45117 Essen, Germany
    Biomaterials 27:3147-53. 2006
    ..The dispersions were stable and could be used for transfection after 2 weeks of storage at 4 degrees C without loss of efficiency...
  5. ncbi Tissue-engineered bone using mesenchymal stem cells and a biodegradable scaffold
    Jae Seong Boo
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Nagoya University, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    J Craniofac Surg 13:231-9; discussion 240-3. 2002
    ..The fabricated synthetic bone using biodegradable beta-TCP as a scaffold in vivo is useful for reconstructing bone, because the scaffold material is absorbed several months after implantation...
  6. ncbi Comparative in vivo study of six hydroxyapatite-based bone graft substitutes
    Pamela Habibovic
    University of Twente, Department of Tissue Regeneration, Enschede, The Netherlands
    J Orthop Res 26:1363-70. 2008
    ....
  7. ncbi The importance of particle size and DNA condensation salt for calcium phosphate nanoparticle transfection
    Claudio E Pedraza
    Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
    Biomaterials 29:3384-92. 2008
    ..We found that the key parameters for effective calcium phosphate nanoparticle transfection were an optimal concentration of calcium and chloride ions and a nanosized non-agglomerated precipitate...
  8. ncbi Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery
    Jun Li
    Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Control Release 142:416-21. 2010
    ..The untargeted NP showed a very low silencing effect. The new formulation improved the in vitro silencing effect 3-4 folds compared to the previous LPD formulation, but had a negligible immunotoxicity...
  9. ncbi Calcium phosphate nanoparticles as novel non-viral vectors for targeted gene delivery
    Indrajit Roy
    Department of Chemistry, University of Delhi, Delhi 110007, India
    Int J Pharm 250:25-33. 2003
    ..We have demonstrated in our studies that these surface modified calcium phosphate nanoparticles can be used in vivo to target genes specifically to the liver...
  10. ncbi Calcium phosphate nanoparticles as a novel nonviral vector for efficient transfection of DNA in cancer gene therapy
    Ting Liu
    Xiangya Hospital, Central South University, Changsha 410078, Hunan Province, People's Republic of China
    Cancer Biother Radiopharm 20:141-9. 2005
    ..Our results showed that the CPNP might be a potential vector for gene therapy...
  11. ncbi Transfection of adherent and suspended cells by calcium phosphate
    Martin Jordan
    LBTC, Laboratory of Cellular Biotechnology, EPFL, Lausanne Switzerland
    Methods 33:136-43. 2004
    ..Examples of protocols that were established and tested within the authors' laboratory are presented. The article also emphasizes differences between transfections of adherent and suspended cells...
  12. ncbi Beta-TCP bone graft substitutes in a bilateral rabbit tibial defect model
    William R Walsh
    Surgical and Orthopaedic Research Laboratories, University of New South Wales, Prince of Wales Hospital, L1 Clinical Sciences Building, Sydney 2031, Australia
    Biomaterials 29:266-71. 2008
    ..Vitoss resorbed faster than the other materials and is likely to differences in particle geometry, pore structure and interconnectivity...
  13. ncbi Lipid-coated nano-calcium-phosphate (LNCP) for gene delivery
    Chenguang Zhou
    Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Int J Pharm 392:201-8. 2010
    ....
  14. ncbi A novel amorphous calcium phosphate polymer ceramic for bone repair: I. Synthesis and characterization
    A M Ambrosio
    Center for Advanced Biomaterials and Tissue Engineering, Department of Chemical Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, Pennsylvania 19104, USA
    J Biomed Mater Res 58:295-301. 2001
    ..Sintering the composite microspheres together yielded a bioresorbable, porous, 3-dimensional scaffold that may be ideal for tissue ingrowth, making this composite scaffold potentially suitable for bone repair applications...
  15. ncbi Promotion of bone formation using highly pure porous beta-TCP combined with bone marrow-derived osteoprogenitor cells
    Jian Dong
    Tissue Engineering Research Center, National Institute of Advanced Industrial Science and Technology, Ibaraki, Japan
    Biomaterials 23:4493-502. 2002
    ..These results showed that tissue engineering treatment on incubating the composites of beta-TCP and BMO cells in osteogenic medium results in a good osteogenic activity...
  16. ncbi Spontaneous growth of a laminin-apatite nano-composite in a metastable calcium phosphate solution
    Ayako Oyane
    Nanotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, Central 5, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8565, Japan
    Biomaterials 27:167-75. 2006
    ..solution was stable for periods as long as 24 h; it did not induce homogeneous precipitation of laminin or calcium phosphates in the solution...
  17. ncbi Performance of hydroxyapatite bone repair scaffolds created via three-dimensional fabrication techniques
    Tithi Dutta Roy
    Departtment of Orthopaedics, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, MSB G-574, Newark, New Jersey 07103, USA
    J Biomed Mater Res A 67:1228-37. 2003
    ..Therefore, the current study indicates that scaffold geometry, as determined by the fabrication process, can enhance the ability of a ceramic material to accelerate healing of calvarial defects...
  18. ncbi A poly(lactic acid)/calcium metaphosphate composite for bone tissue engineering
    Youngmee Jung
    Biomaterials Research Center, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea
    Biomaterials 26:6314-22. 2005
    ..As the novel sintering method does not use any solvents it offers another advantage to avoid problems associated with solvent residue...
  19. ncbi A preliminary study on osteoinduction of two kinds of calcium phosphate ceramics
    H Yuan
    Institute of Materials Science and Technology, Sichuan Union University, Chengdu, People s Republic of China
    Biomaterials 20:1799-806. 1999
    ..These data suggest that, by controlling the preparation of calcium phosphate ceramic, bone substitutes with intrinsic osteoinductive property can be developed from calcium phosphates.
  20. ncbi Surface modification of tricalcium phosphate for improvement of the interfacial compatibility with biodegradable polymers
    Carmen Kunze
    Institute of Materials Sciences, Polymer Engineering, Martin-Luther University Halle-Wittenberg, D-06099 Halle/Saale, Germany
    Biomaterials 24:967-74. 2003
    ..Chemical bonds between filler and polymer matrix are assumed to be formed by transesterification reactions...
  21. ncbi Improved bone ingrowth and fixation with a thin calcium phosphate coating intended for complete resorption
    O Reigstad
    Orthopaedic Department, Rikshospitalet National Hospital, 0027 Oslo, Norway
    J Biomed Mater Res B Appl Biomater 83:9-15. 2007
    ..This unloaded short-term study has shown promising results for the easily applicable and resorbable coat (Bonit) compared to uncoated titanium-alloy implants...
  22. ncbi The use of hydroxyapatite and autogenous cancellous bone grafts to repair bone defects in rats
    R V Silva
    Department of Anatomy, Institute of Biology, State University of Campinas, Campinas, , Brazil
    Int J Oral Maxillofac Surg 34:178-84. 2005
    ..These results indicated that the osteointegration of bioceramic fragments allowed the reconstruction of parietal bone defects without the need for a bone graft...
  23. ncbi Cellular investigations on electrochemically deposited calcium phosphate composites
    Petra Becker
    DOT GmbH, Charles Darwin Ring 1a, 18059 Rostock, Germany
    J Mater Sci Mater Med 15:437-40. 2004
    ..Thus we suggest that brushite seems to be especially suitable for coating of implants as a matrix for nucleation and growth of new bone...
  24. ncbi Electrochemical processes of nucleation and growth of calcium phosphate on titanium supported by real-time quartz crystal microbalance measurements and X-ray photoelectron spectroscopy analysis
    Noam Eliaz
    Biomaterials and Corrosion Laboratory, School of Mechanical Engineering, Tel Aviv University, Ramat Aviv 69978, Israel
    J Biomed Mater Res A 89:270-80. 2009
    ..crystal microbalance (EQCM) measurements are conducted to better understand the electrocrystallization of calcium phosphates (CaP) on CP-Ti...
  25. ncbi A low-temperature biomimetic calcium phosphate surface enhances early implant fixation in a rat model
    S Kuroda
    Department of Anatomy and Cell Biology, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Biomed Mater Res A 70:66-73. 2004
    ..011), suggesting that the bone formed a stronger bond to the apatite coating than to the titanium. This difference in bonding strength accounted for the difference in mechanical behavior...
  26. ncbi In vitro synthesis and characterization of amorphous calcium phosphates with various Ca/P atomic ratios
    Yanbao Li
    Department of Materials of Science and Engineering, Zhejiang University, Hangzhou 310027, PR China
    J Mater Sci Mater Med 18:2303-8. 2007
    Amorphous calcium phosphates (ACP) were synthesized utilizing poly(ethylene glycol) as stabilizing additive at low temperature...
  27. ncbi Controlled synthesis of plate-shaped hydroxyapatite and implications for the morphology of the apatite phase in bone
    B Viswanath
    Materials Research Centre, Indian Institute of Science, Bangalore 560 012, India
    Biomaterials 29:4855-63. 2008
    ..The synthesis and analysis presented here have important implications for understanding the plate-shaped morphology of apatite crystals that exist in the bone...
  28. ncbi Modification of gene expression induced in human osteogenic and osteosarcoma cells by culture on a biphasic calcium phosphate bone substitute
    N Rochet
    INSERM U364, IFR50, Faculte de Medecine, Avenue de Valombrose, 06107 Nice Cedex 02, France
    Bone 32:602-10. 2003
    ..Owing to the nature and spatial organization of the BCP, our hypothesis is that culture on BCP is closer to the physiological situation than culture on plastic...
  29. ncbi Osteogenic differentiation of cultured rat and human bone marrow cells on the surface of zinc-releasing calcium phosphate ceramics
    Masako Ikeuchi
    National Institute of Advanced Industrial Science and Technology (AIST, Tissue Engineering Research Center (TERC, 3-11-46 Nakouji, Amagasaki, Hyougo 661-0974, Japan
    J Biomed Mater Res A 67:1115-22. 2003
    ....
  30. ncbi In vivo bone response and mechanical evaluation of electrosprayed CaP nanoparticle coatings using the iliac crest of goats as an implantation model
    Corinne Schouten
    Department of Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Acta Biomater 6:2227-36. 2010
    ....
  31. ncbi Effect of carbonate content and buffer type on calcium phosphate formation in SBF solutions
    S Jalota
    School of Materials Science and Engineering, Clemson University, Clemson, SC 29634, USA
    J Mater Sci Mater Med 17:697-707. 2006
  32. ncbi Integrin-supported fast rate intracellular delivery of plasmid DNA by extracellular matrix protein embedded calcium phosphate complexes
    E H Chowdhury
    Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan
    Biochemistry 44:12273-8. 2005
    ....
  33. ncbi Physicochemical evaluation of bioactive polymeric composites based on hybrid amorphous calcium phosphates
    D Skrtic
    American Dental Association Health Foundation Paffenbarger Research Center, National Institute of Standards and Technology, Gaithersburg, MD 20899 8546, USA
    J Biomed Mater Res 53:381-91. 2000
    ..Therefore, hybridized ACP-filled BTHZ composites have a potential for utilization in more demanding restorative, sealant, and adhesive applications...
  34. ncbi Calcium phosphates as bone graft extenders
    Evalina L Burger
    University of Colorado Health Sciences Spine Center, Aurora, Colorado 80045, USA
    Orthopedics 30:939-42. 2007
    ..Thus, this article presents a comparative analysis of the physiochemical attributes of calcium phosphate materials used in spine surgery...
  35. ncbi Amorphous calcium phosphates: synthesis, properties and uses in biomaterials
    C Combes
    Universite de Toulouse, CIRIMAT, UPS INPT CNRS, ENSIACET, 4 allée Emile Monso, BP 44362, 31432 Toulouse Cedex 4, France
    Acta Biomater 6:3362-78. 2010
    This review paper on amorphous calcium phosphates (ACPs) provides an update on several aspects of these compounds which have led to many studies and some controversy since the 1970s, particularly because of the lack of irrefutable proof ..
  36. ncbi Influence of anodization on the adhesion of calcium phosphate coatings on titanium substrates
    Daniel J Blackwood
    Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576
    J Biomed Mater Res A 93:1551-6. 2010
    ..However, adhesion becomes independent of surface finish at levels smoother than 600 grit, suggesting that mechanical interlocking is not the sole force at play...
  37. ncbi Evaluation of the biocompatibility of calcium phosphate cement/PLGA microparticle composites
    Dennis P Link
    Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Biomed Mater Res A 87:760-9. 2008
    ..Therefore, CaP/PLGA composites can be regarded as biocompatible biomaterials with potential for bone tissue engineering and advantageous possibilities of the microparticles regarding material porosity...
  38. ncbi Transfer of high copy number plasmid into mammalian cells by calcium phosphate transfection
    P Batard
    Swiss Federal Institute of Technology Lausanne, Center of Biotechnology CBUE, Department of Chemistry, 1015, Lausanne, Switzerland
    Gene 270:61-8. 2001
    ..While cells with maximal DNA load appear to express the highest level of the transgene, these cells are negatively impacted in terms of growth and survival...
  39. ncbi The role of calcium gluconate in electrochemical activation of titanium for biomimetic coating of calcium phosphate
    S M A Shibli
    Department of Chemistry, University of Kerala, Kariavattom Campus, Thiruvananthapuram, Kerala 695 581, India
    J Biomed Mater Res A 87:994-1002. 2008
    ..5 times higher concentration of Ca. Biomimetic growth was also improved by the addition of calcium gluconate in the SBF solution...
  40. ncbi Formation and transformation of amorphous calcium phosphates on titanium alloy surfaces during atmospheric plasma spraying and their subsequent in vitro performance
    Robert B Heimann
    Universitätszentrum Medizintechnik, Ruhr Universitat Bochum, D 44801 Bochum, Germany
    Biomaterials 27:823-31. 2006
    ..During incubation of hydroxyapatite without a bond coat for 1 week diffusion bands were formed within the ACP of 1-2 microm width parallel to the interface metal/coating, presumably by a dissolution-precipitation sequence...
  41. ncbi Osseous integration of calcium phosphate in osteoporotic vertebral fractures after kyphoplasty: initial results from a clinical and experimental pilot study
    M Libicher
    Department of Diagnostic Radiology, University of Heidelberg, Heidelberg, Germany
    Osteoporos Int 17:1208-15. 2006
    ..01). CONCLUSIONS: The decrease of the BVD 12 months after kyphoplasty may indicate osseous integration of CPC by: (1) the ingrowth of bone tissue and (2) osteonal penetration close to the interface...
  42. ncbi Cross-species comparison of ectopic bone formation in biphasic calcium phosphate (BCP) and hydroxyapatite (HA) scaffolds
    Huipin Yuan
    BMTI, Twente University, Enschede, The Netherlands
    Tissue Eng 12:1607-15. 2006
    ..In dogs (N = 8), all implants showed bone formation with significantly more bone formed in biphasic calcium phosphates (30 +/- 6%, N = 8) as compared to hydroxyapatite (14 +/- 5%, N = 8) (p = 0.003)...
  43. ncbi Cell growth and function on calcium phosphate reinforced chitosan scaffolds
    Yong Zhang
    Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195-2120 USA
    J Mater Sci Mater Med 15:255-60. 2004
    ..Larger amount of soluble calcium phosphate invert glasses should be added into the scaffolds to prevent chitosan from fast degradation that may affect the differentiation of osteoblast cells...
  44. ncbi Customizing the degradation and load-bearing profile of 3D polycaprolactone-tricalcium phosphate scaffolds under enzymatic and hydrolytic conditions
    Alvin Yeo
    Department of Restorative Dentistry, National Dental Centre, SingHealth, Singapore, Singapore
    J Biomed Mater Res B Appl Biomater 87:562-9. 2008
    ....
  45. ncbi Effect of recombinant human bone morphogenetic protein-4 dose on bone formation in a rat calvarial defect model
    Eun-Kyoung Pang
    Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea
    J Periodontol 75:1364-70. 2004
    ..Within the selected rhBMP-4 dose range and observation interval, there appeared to be no meaningful differences in bone formation...
  46. ncbi Ectopic bone formation associated with recombinant human bone morphogenetic proteins-2 using absorbable collagen sponge and beta tricalcium phosphate as carriers
    Chang-Sung Kim
    Department of Periodontology, Research Institute for Periodontal Regeneration, Brain Korea 21 Project for Medical Science, College of Dentistry, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul 120752, Republic of Korea
    Biomaterials 26:2501-7. 2005
    ..Therefore, a carrier for BMPs should provide space for bone formation and maturation during the more advanced healing stages...
  47. ncbi Novel PCL-based honeycomb scaffolds as drug delivery systems for rhBMP-2
    B Rai
    Faculty of Dentistry, National University of Singapore, Singapore
    Biomaterials 26:3739-48. 2005
    ..Sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) and alkaline phosphatase assay verified the stability and bioactivity of eluted rhBMP-2 at all time points...
  48. ncbi Performance of functionally graded implants of polylactides and calcium phosphate/calcium carbonate in an ovine model for computer assisted craniectomy and cranioplasty
    Harald Eufinger
    Department of Oral and Maxillofacial Plastic Surgery, Academic Teaching Hospital Recklinghausen, University of Bochum, Dorstener Street 150, 45657 Recklinghausen, Germany
    Biomaterials 28:475-85. 2007
    ..The formation of new bone from the dural layer of the meninges corresponded well to the degradation of the porous inner layer of the implants whereas the skull contour was stabilised by the compact outer layer over the follow-up period...
  49. ncbi [Synovial fluid crystal identification by electron microscopy]
    Patrícia Nero
    Servico de Reumatologia, Hospital de Egas Moniz, Lisboa
    Acta Reumatol Port 31:75-81. 2006
    ..Nevertheless, sometimes we are unable to identify crystals by these means, either because they are too small or because they are widespread on the fluid...
  50. ncbi HA/TCP compounding of a porous CaP biomaterial improves bone formation and scaffold degradation--a long-term histological study
    Christian Schopper
    Department of Cranio Maxillofacial and Oral Surgery, Medical University of Vienna, Austria
    J Biomed Mater Res B Appl Biomater 74:458-67. 2005
    ....
  51. ncbi Biological and physico-chemical assessment of hydroxyapatite (HA) with different porosity
    J C Hornez
    Laboratoire des Matériaux et Procédés, EA 2443, UVHC, 59600 Maubeuge, France
    Biomol Eng 24:505-9. 2007
    ..This purity and the micro-porosity stimulate significantly cell growth...
  52. ncbi A biodegradable porous composite scaffold of PGA/beta-TCP for bone tissue engineering
    Hong Cao
    Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo, Japan
    Bone 46:386-95. 2010
    ..Thus the PGA/beta-TCP composite scaffold, especially weight ratio 1:3, exhibited a strong ability for osteogenesis, mineralization and biodegradation for bone replacement...
  53. ncbi Augmentation of mechanical properties in osteoporotic vertebral bones--a biomechanical investigation of vertebroplasty efficacy with different bone cements
    P F Heini
    Department of Orthopaedic Surgery, Spine Service, Inselspital, University of Bern, Freiburgstrasse, 3010 Bern, Switzerland
    Eur Spine J 10:164-71. 2001
    ..Both PMMA and EBC augmentation reliably and significantly raised the stiffness and maximal tolerable force until failure in osteoporotic vertebral bodies. In non-porotic specimens, no significant increase was achieved...
  54. ncbi Calcium phosphate nanoparticle adjuvant
    Q He
    BioSante Pharmaceuticals, Inc, Smyrna, Georgia 30082, USA
    Clin Diagn Lab Immunol 7:899-903. 2000
    ..These studies were performed with animal models. By virtue of the potency of this CAP adjuvant and the relative absence of side effects, we believe that this new CAP formulation has great potential for use as an adjuvant in humans...
  55. ncbi Trabecular bone response to injectable calcium phosphate (Ca-P) cement
    E M Ooms
    Department of Biomaterials, College of Dental Science, University Medical Center Nijmegen, P. O. Box 9101, 6500 HB, The Netherlands
    J Biomed Mater Res 61:9-18. 2002
    ..The results indicate that the investigated Ca-P cement is biocompatible, osteoconductive, as well as osteotransductive and is a candidate material for use as a bone substitute...
  56. ncbi Biomechanical evaluation of kyphoplasty and vertebroplasty with calcium phosphate cement in a simulated osteoporotic compression fracture
    Seiji Tomita
    Department of Orthopedic Surgery, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki 569-8686, Japan
    J Orthop Sci 8:192-7. 2003
    ..We concluded that kyphoplasty and vertebroplasty with CPC were viable treatment alternatives to PMMA for osteoporotic vertebral compression fractures...
  57. ncbi Reconstruction of bone using calcium phosphate bone cements: a critical review
    J P Schmitz
    Department of Oral and Maxillo Facial Surgery, The University of Texas Health Science Center at San Antonio 78284 7823, USA
    J Oral Maxillofac Surg 57:1122-6. 1999
    ..This review provides an overall commentary on the different types of CPCs, emphasizing those materials currently on the market or soon to emerge in the marketplace...
  58. ncbi An improvement in sintering property of beta-tricalcium phosphate by addition of calcium pyrophosphate
    Hyun-Seung Ryu
    School of Materials Science and Engineering, College of Engineering, Seoul National University, South Korea
    Biomaterials 23:909-14. 2002
    ..Due to this effect of CPP added to TCP, CPP-doped beta-TCP ceramics with relative density over 95% could be obtained when sintered at 1200 degrees C for 2 h...
  59. ncbi Initial interaction of rat bone marrow cells with non-coated and calcium phosphate coated titanium substrates
    P J ter Brugge
    Department of Biomaterials, College of Dental Science, University Medical Center Nijmegen, The Netherlands
    Biomaterials 23:3269-77. 2002
    ..On the other hand, spreading behavior and cell morphology do depend on substrate surface characteristics...
  60. ncbi The high prevalence of pathologic calcium crystals in pre-operative knees
    Beth A Derfus
    Department of Medicine, Medical College of Wisconsin, Milwaukee, USA
    J Rheumatol 29:570-4. 2002
    ..This information could also potentially aid in predicting the likelihood of the need for contralateral total knee arthroplasty...
  61. ncbi Bone regeneration by implantation of purified, culture-expanded human mesenchymal stem cells
    S P Bruder
    Osiris Therapeutics, Baltimore, Maryland 21231, USA
    J Orthop Res 16:155-62. 1998
    ..These studies demonstrate that human mesenchymal stem cells can regenerate bone in a clinically significant osseous defect and may therefore provide an alternative to autogenous bone grafts...
  62. ncbi Osteoclastic resorption of biomimetic calcium phosphate coatings in vitro
    S Leeuwenburgh
    Laboratory for Inorganic Chemistry, Delft University of Technology, Delft, The Netherlands
    J Biomed Mater Res 56:208-15. 2001
    ..The results showed that carbonated apatite coatings are resorbed by osteoclasts in a manner consistent with normal osteoclastic resorption. Osteoclasts also degraded the octacalcium phosphate coatings but not by classical pit formation...
  63. ncbi Polymer--calcium phosphate cement composites for bone substitutes
    Rafal A Mickiewicz
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139-4307, USA
    J Biomed Mater Res 61:581-92. 2002
    ..The increased strength was attributed to the polymer's capacity to bridge between multiple crystallites (thus forming a more cohesive composite) and to absorb energy through plastic flow...
  64. ncbi A 1-year study of hydroxyapatite-derived biomaterials in an adult sheep model: III. Comparison with autogenous bone graft for facial augmentation
    Arun K Gosain
    Division of Plastic Surgery, Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Plast Reconstr Surg 116:1044-52. 2005
    ..The present study investigates onlay bone grafts and implants in a large-animal (sheep) model to determine whether there are composite biomaterials that can maximize long-term facial augmentation when compared with conventional bone grafts...
  65. ncbi Porous calcium phosphate ceramic granules and their behaviour in differently loaded areas of skeleton
    Z Zyman
    Physics of Solids Department, V N Karazin Kharkiv National University, 4 Svoboda Square, Kharkiv 61077, Ukraine
    J Mater Sci Mater Med 19:2197-205. 2008
    ..The developed CPC materials seems to have good perspective for using in bone defect plasty in some loaded areas of the skeleton...
  66. ncbi The biodegradation mechanism of calcium phosphate biomaterials in bone
    Jianxi Lu
    Laboratoire Interface Matrice Extracellulaire Biomatériaux, Faculté d odontologie de Marseille, France
    J Biomed Mater Res 63:408-12. 2002
    ..However, the bone cement is formed by physicochemical crystallization and is degraded through a dissolution process associated with a cellular process...
  67. ncbi Calcium phosphate cement composites in revision hip arthroplasty
    Andrew D Speirs
    Division of Orthopaedic Engineering Research, Department of Orthopaedics and Mechanical Engineering, University of British Columbia, Vancouver, Canada BC V5Z 4E3
    Biomaterials 26:7310-8. 2005
    ..Further testing is required to evaluate the in vitro mechanical performance, as well as in vivo remodelling characteristics...
  68. ncbi Osteoblast interactions with calcium phosphate ceramics modified by coating with type I collagen
    J C Brodie
    Bioengineering Unit, University of Strathclyde, Wolfson Centre, 106 Rottenrow, Glasgow G4 0NW, Scotland, United Kingdom
    J Biomed Mater Res A 73:409-21. 2005
    ..Results indicate that collagen coating of calcium phosphate ceramics may also increase their compatibility and osseointegration in vivo...
  69. ncbi In vitro studies of human and rat osteoclast activity on hydroxyapatite, beta-tricalcium phosphate, calcium carbonate
    F Monchau
    Laboratoire de Recherche sur les Biomatériaux, Departement de Biophysique, Faculte de Medecine, UPRES EA 1049, 1, Place de Verdun, F 59045 Lille Cedex, France
    Biomol Eng 19:143-52. 2002
    ..The both cell models found these characteristics, the rat osteoclasts were also an excellent model to study the ceramic resorption...
  70. ncbi Ectopic bone formation associated with mesenchymal stem cells in a resorbable calcium deficient hydroxyapatite carrier
    Philip Kasten
    Department of Orthopaedic Surgery, University of Heidelberg, Schlierbacher Landstr 200A, 69118 Heidelberg, Germany
    Biomaterials 26:5879-89. 2005
    ..Ectopic bone formation in the novel biomaterial CDHA varied considerably with the cell pool and was at least equal to beta-TCP blocks...
  71. ncbi Fully injectable calcium phosphate cement--a promise to dentistry
    Manoj Komath
    Sree Chitra Tirunal Institute for Medical Sciences Technology, Poojappur, Thiruvananthapuram
    Indian J Dent Res 15:89-95. 2004
    ..The set cement provides good and stable sealing. The osteoconductive property is an added advantage. FI-CPC proves to be an ideal material for endodontic sealing/filling and periodontic repair...
  72. ncbi Mechanical characterization of dense calcium phosphate bioceramics with interconnected porosity
    Y H Hsu
    Centre for Orthopaedic Biomechanics, Department of Mechanical Engineering, University of Bath, Claverton Down, Bath BA2 7AY, UK
    J Mater Sci Mater Med 18:2319-29. 2007
    ..The results indicated that it is possible to manufacture open pore HA/TCP bioceramics, with compressive strengths comparable to human bone, which could be of significant clinical interest...
  73. ncbi Cyclic silicate active site and stereochemical match for apatite nucleation on pseudowollastonite bioceramic-bone interfaces
    Nita Sahai
    Department of Geology and Geophysics, 1215 West Dayton Street, University of Wisconsin, Madison, WI 53706, USA
    Biomaterials 26:5763-70. 2005
    ..A critical active site-density and a point of zero charge of the bioceramic less than physiological pH are required for bioactivity...
  74. ncbi Technological issues for the development of more efficient calcium phosphate bone cements: a critical assessment
    M Bohner
    Dr Robert Mathys Foundation, Bischmattstrasse 12, CH 2544 Bettlach, Switzerland
    Biomaterials 26:6423-9. 2005
    ..Two decades later, the interest for these materials is still rising. The goal of the present document is to review the most recent achievements in the field and to analyze future directions in research and development...
  75. ncbi Macroporous calcium phosphate glass-ceramic prepared by two-step pressing technique and using sucrose as a pore former
    Cong Wang
    Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya, 466-8555, Japan
    J Mater Sci Mater Med 16:739-44. 2005
    ..These, together with the simplicity and feasibility of the innovative fabrication method itself, show that the formed porous glass-ceramic has a promising potential for application to a scaffold for bone tissue engineering...
  76. ncbi A comparative study of calcium phosphate formation on bioceramics in vitro and in vivo
    Renlong Xin
    Department of Mechanical Engineering, Hong Kong University of Science and Technology, Hong Kong, China
    Biomaterials 26:6477-86. 2005
    ..Apatite formation in physiological environments cannot be confirmed as a common feature of bioceramics...
  77. ncbi Developing better artificial bones
    Edward D Flinn
    Aerosp Am 41:20-1. 2003
    ..The Space-DRUMS uses acoustic pressure beams to maintain the position of a suspended liquid or solid. Space-DRUMS will be used to extend experiments with tricalcium phosphate in the development of artificial bone material...
  78. ncbi The mechanical properties of calcium phospate ceramics modified by collagen coating and populated by osteoblasts
    J C Brodie
    Bioengineering Unit, Strathclyde University, Wolfson Centre, 106 Rottenrow, Glasgow G4 0NW
    J Mater Sci Mater Med 17:43-8. 2006
    ..Although collagen coating has been found to increase the proliferation of osteoblasts into these ceramic materials, it may be necessary to stabilise and optimise the coating process to minimise effects on mechanical strength...
  79. ncbi Nanoindentation on porous bioceramic scaffolds for bone tissue engineering
    S Chowdhury
    Department of Physics, University of Alabama at Birmingham, Birmingham, Alabama 35294-1170, USA
    J Nanosci Nanotechnol 5:1816-20. 2005
    ....
  80. ncbi Phase development and sintering behaviour of biphasic HA-TCP calcium phosphate materials prepared from hydroxyapatite and bioactive glass
    A Behnamghader
    Materials and Energy Research Centre, P O Box 14155 4777, Tehran, Iran
    J Mater Sci Mater Med 19:197-201. 2008
    ..The characterizations revealed considerable content of TCP in the form of large semi-islands due to important reactions between the fine HA and the glass mixed powders...
  81. ncbi Comparison of osteoconductive materials on MG63 osteoblast cell function
    Mark Barron
    University of Mississippi Medical Center, Jackson, MS 39216, USA
    Biomed Sci Instrum 43:248-53. 2007
    ..The overall results suggest a favorable environment for bone cell growth on TCP and ZnCaP materials. The materials may serve as delivery systems for cells in tissue engineering fields in the future...
  82. ncbi Surface structural biomimetics and the osteoinduction of calcium phosphate biomaterials
    Hongsong Fan
    National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China
    J Nanosci Nanotechnol 7:808-13. 2007
    ....
  83. ncbi Investigation of a thermoplastic polymeric carrier for bone tissue engineering using allogeneic mesenchymal stem cells in granular scaffolds
    Dimitrios Mylonas
    Department of Prosthodonthics, UNC School of Dentistry, Chapel Hill, NC 27599, USA
    J Prosthodont 16:421-30. 2007
    ....
  84. ncbi Preparation and properties of chitosan/calcium phosphate composites for bone repair
    Shinn Jyh Ding
    Institute of Oral Materials Science, Chung Shan Medical University, Taichung 402, Taiwan, Republic of China
    Dent Mater J 25:706-12. 2006
    ..It was thus concluded that hybrid biocomposites with initial high strength might be a potential implant candidate for bone defect repair...
  85. ncbi Carvable calcium phosphate bone substitute material
    M P Hofmann
    Biomaterials Unit, School of Dentistry, University of Birmingham, Birmingham B4 6NN, UK
    J Biomed Mater Res B Appl Biomater 83:1-8. 2007
    ..The development of compressive strength, phase composition, and crystallinity when varying production parameters of these partially "preset" bone substitute materials are presented for both cement systems...
  86. ncbi The thermal stability of hydroxyapatite in biphasic calcium phosphate ceramics
    R W N Nilen
    Materials Science and Manufacturing Unit, Council for Scientific and Industrial Research, P O Box 395, Pretoria 0001, South Africa
    J Mater Sci Mater Med 19:1693-702. 2008
    ....
  87. ncbi Bone augmentation in rabbit calvariae: comparative study between Bio-Oss and a novel beta-TCP/DCPD granulate
    Faleh Mariño Tamimi
    Departamento Química Física II, Complutense University of Madrid UCM, Madrid 28040, Spain
    J Clin Periodontol 33:922-8. 2006
    ..In the present in vivo study, we compare the bone regeneration capacity of a novel brushite cement synthesized in our laboratory (DTG) with Bio-Oss using rabbits as an animal model...
  88. ncbi Influence of platelet-rich plasma on osteogenic differentiation of mesenchymal stem cells and ectopic bone formation in calcium phosphate ceramics
    Philip Kasten
    Division of Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, Heidelberg, Germany
    Cells Tissues Organs 183:68-79. 2006
    ..In conclusion, the effect of PRP depended on the type of ceramic and the differentiation status of the MSC, and enhanced ALP activity of MSC on the high surface scaffold CDHA only, but PRP did not improve osteogenesis in our setting...
  89. ncbi Role of scaffold internal structure on in vivo bone formation in macroporous calcium phosphate bioceramics
    Maddalena Mastrogiacomo
    Dip. di Oncologia, Biologia e Genetica, , Italy
    Biomaterials 27:3230-7. 2006
    ..Here we show that porosity and pore interconnection of osteoconductive scaffolds can influence the overall amount of bone deposition, the pattern of blood vessels invasion and finally the kinetics of the bone neoformation process...
  90. ncbi Development of a nonrigid, durable calcium phosphate cement for use in periodontal bone repair
    Hockin H K Xu
    Paffenbarger Researcher Center, American Dental Association Foundation, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    J Am Dent Assoc 137:1131-8. 2006
    ....
  91. ncbi Preparation of porous apatite granules from calcium phosphate cement
    A C Tas
    Department of Biomedical Engineering, Yeditepe University, Istanbul 34755, Turkey
    J Mater Sci Mater Med 19:2231-9. 2008
    ..The granules reached their final handling strength at the ambient temperature through the cement setting reaction, without having a need for sintering...
  92. ncbi Synthetic bone graft substitutes
    W R Moore
    Department of Orthopaedic Surgery, Modbury Public Hospital, Modbury, Australia
    ANZ J Surg 71:354-61. 2001
    ..The benefits of synthetic grafts include availability, sterility and reduced morbidity. The present article examines the relevance of synthetic bone graft substitutes, their mechanical properties and clinical application...
  93. ncbi Preparation of tricalcium phosphate/calcium pyrophosphate structures via rapid prototyping
    Uwe Gbureck
    Department for Functional Materials in Medicine and Dentistry, University of Wurzburg, Pleicherwall 2, 97070 Wurzburg, Germany
    J Mater Sci Mater Med 19:1559-63. 2008
    ....
  94. ncbi Preparation and characterisation of calcium-phosphate porous microspheres with a uniform size for biomedical applications
    C C Ribeiro
    INEB Instituto de Engenharia Biomedica, Laboratorio de Biomateriais, Rua do Campo Alegre 823, 4150 180, Porto, Portugal
    J Mater Sci Mater Med 17:455-63. 2006
    ..2 microm. Depending on the formulations tested, the structure of both calcium phosphates may become altered during the sintering process, suggesting that the ratio between the ceramic phase and the ..
  95. ncbi Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics
    Songfeng Xu
    Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi an 710032, PR China
    Biomaterials 29:2588-96. 2008
    ..The present studies showed that the porous beta-CS ceramics could stimulate bone regeneration and may be used as bioactive and biodegradable materials for hard tissue repair and tissue engineering applications...
  96. ncbi A concept for the treatment of various dental bone defects
    Ady Palti
    Implant Dent 11:73-8. 2002
    ..The representative cases described in this paper demonstrate the successful use of the pure-phase beta-tricalcium phosphate ceramic in the treatment of all dental bone defects...
  97. ncbi Preparation and characterization of calcium phosphate biomaterials
    A R Calafiori
    Department of Cell Biology, University of Calabria, P Bucci 4c, Rende, CS 87030, Italy
    J Mater Sci Mater Med 18:2331-8. 2007
    ..MCPM/CC mixture has a 30% HAp final concentration and is characterized by higher porosity (amount 78%) and mechanical properties useful as filler in bone segments without high mechanical stress...
  98. ncbi Mechanical properties and in-vivo performance of calcium phosphate cement-chitosan fibre composite
    Q Lian
    State Key Laboratory for Manufacturing, Systems Engineering, Xi an Jiaotong University, Xi an, Shaanxi, People s Republic of China
    Proc Inst Mech Eng H 222:347-53. 2008
    ..Briefly, the incorporation of a suitable chitosan-fibre structure into a CPC implant not only could improve its mechanical properties but also facilitated the bone repair process in vivo...
  99. ncbi SHED repair critical-size calvarial defects in mice
    B M Seo
    Department of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University, Seoul, Korea
    Oral Dis 14:428-34. 2008
    ..To examine whether SHED-mediated bone regeneration can be utilized for therapeutic purposes, we used SHED to repair critical-size calvarial defects in immunocompromised mice...
  100. ncbi In vitro and in vivo performance of Ti6Al4V implants with plasma-sprayed osteoconductive hydroxylapatite-bioinert titania bond coat "duplex" systems: an experimental study in sheep
    R B Heimann
    Department of Mineralogy, Technische Universitat Bergakademie Freiberg, D 09596 Freiberg, Germany
    J Mater Sci Mater Med 15:1045-52. 2004
    ..Some tentative mechanisms leading to this improved coating adhesion will be discussed...
  101. ncbi Evaluation of a resorbable, in situ setting bone substitute in a sheep model
    Christopher Niedhart
    Department of Orthopedic Surgery, University of Aachen, Pauwelsstr 30, Pauwelsstr 30, D 52074 Aachen, Germany
    J Biomed Mater Res B Appl Biomater 71:123-9. 2004
    ..026). In conclusion, this new in situ setting cement is bioactive, resorbable, and osteoconductive. It will be useful as an alternative to autologous bone graft to fill stable defects...

Research Grants66

  1. KINETICS OF MINERALIZATION OF TEETH
    GEORGE NANCOLLAS; Fiscal Year: 1990
    ..Electrophoretic mobilities of enamel, dentin, calculus, and synthetic calcium phosphates will be determined in the presence of both simple inorganic ions and salivary proteins...
  2. POLYURETHANE CALCIFICATION, MECHANISM AND INHIBITION
    Robert Levy; Fiscal Year: 2000
    ..part to the propensity of this material to provide an appropriate nucleating and crystal growth surface for calcium phosphates; 2) We hypothesize that the predominantly surface oriented polyurethane calcification is due to adsorption ..
  3. 2004-2006 Biomineralization Gordon Research Conferences
    Joanna Aizenberg; Fiscal Year: 2006
    ..the Conference include: the structure of the mineral in organs of vertebrates and invertebrates, including calcium phosphates, carbonates, and silica; the properties and function of the matrix proteins found in mineralized tissues; ..
  4. Functionalizing Hydroxyapatite With Proadhesive Peptides
    Susan Bellis; Fiscal Year: 2007
    ..of materials, however, surprisingly, the class of materials that is among the most osseoconductive, the calcium phosphates, has received the least amount of attention in this regard...
  5. AMORPHOUS CALCIUM PHOSPHATE BASED DENTAL MATERIALS
    Drago Skrtic; Fiscal Year: 2003
    ..formation of hydroxyapatite (HAP), has received less attention as a dental material than crystalline calcium phosphates (CaPs)...
  6. Solid State NMR Structure/Function Studies of Amelogenin
    WENDY SHAW; Fiscal Year: 2007
    ..secondary structure, dynamics and amino acids important in binding the protein or protein self assembly to calcium phosphates. QCM will be used to investigate nucleation rates and protein binding kinetics...
  7. THE KINETICS OF MINERALIZATION OF TEETH
    GEORGE NANCOLLAS; Fiscal Year: 2006
    ..biominerals, we will make surface tension measurements by sessile drop and thin layer wicking on synthetic calcium phosphates and enamel and dentin surfaces both in the absence and presence of modulating additives...
  8. THE KINETICS OF MINERALIZATION OF TEETH
    GEORGE NANCOLLAS; Fiscal Year: 1980
    The overall objective of the proposed research is the characterization of the kinetics of mineralization of calcium phosphates and the inorganic and organic components of teeth such as whole and carious enamel and dentine, predentine, ..
  9. Novel DNA Delivery via Surface Bound Calcium Phosphates
    Jian Tan; Fiscal Year: 2007
    ..The technology developed in this proposal will have important impact on basic research, biotech industry and gene therapy based medicine. ..
  10. NANOSTRUCTURED BIOACTIVE MATERIALS
    Laurence Chow; Fiscal Year: 2007
    ..Aim 3 will evaluate the effectiveness of nano sized calcium phosphates and calcium fluoride in reducing dentin permeability, a property closely associated with dental ..