calcium phosphates

Summary

Summary: Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements.

Top Publications

  1. ncbi Nanostructured calcium phosphates for biomedical applications: novel synthesis and characterization
    Prashant N Kumta
    Department of Materials Science and Engineering, Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Acta Biomater 1:65-83. 2005
  2. ncbi Effect of recombinant human bone morphogenetic protein-4 dose on bone formation in a rat calvarial defect model
    Eun Kyoung Pang
    Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea
    J Periodontol 75:1364-70. 2004
  3. ncbi Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth
    O Gauthier
    Laboratoire de Chirurgie, Ecole Nationale Veterinaire de Nantes, France
    Biomaterials 19:133-9. 1998
  4. ncbi Comparative study of tissue reactions to calcium phosphate ceramics among cancellous, cortical, and medullar bone sites in rabbits
    J X Lu
    Institut de Recherche sur les Maladies du Squelette, Berck sur Mer, France
    J Biomed Mater Res 42:357-67. 1998
  5. pmc Bone regeneration: molecular and cellular interactions with calcium phosphate ceramics
    Florence Barrere
    Biomedical Technological Institute BMTI, University ofTwente, Enschede, The Netherlands
    Int J Nanomedicine 1:317-32. 2006
  6. ncbi Calcium phosphate cements as bone drug delivery systems: a review
    M P Ginebra
    Biomedical Engineering Research Centre, Department of Materials Science and Metallurgical Engineering, Technical University of Catalonia, 08028 Barcelona, Spain
    J Control Release 113:102-10. 2006
  7. ncbi Calcium phosphate composite layers for surface-mediated gene transfer
    Ayako Oyane
    Nanosystem Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
    Acta Biomater 8:2034-46. 2012
  8. ncbi A combination of calcium phosphate and probiotics beneficially influences intestinal lactobacilli and cholesterol metabolism in humans
    Ulrike Trautvetter
    Department of Nutritional Physiology, Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Str 24, D 07743 Jena, Germany
    Clin Nutr 31:230-7. 2012
  9. ncbi Surface-mediated gene transfer from nanocomposites of controlled texture
    Hong Shen
    School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, USA
    Nat Mater 3:569-74. 2004
  10. ncbi The combined bone forming capacity of human periosteal derived cells and calcium phosphates
    Scott J Roberts
    Laboratory for Skeletal Development and Joint Disorders, Katholieke Universiteit Leuven, Belgium
    Biomaterials 32:4393-405. 2011

Detail Information

Publications347 found, 100 shown here

  1. ncbi Nanostructured calcium phosphates for biomedical applications: novel synthesis and characterization
    Prashant N Kumta
    Department of Materials Science and Engineering, Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Acta Biomater 1:65-83. 2005
    ..This paper illustrates our approach to implement calcium phosphates as gene delivery agents...
  2. ncbi Effect of recombinant human bone morphogenetic protein-4 dose on bone formation in a rat calvarial defect model
    Eun Kyoung Pang
    Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea
    J Periodontol 75:1364-70. 2004
    ..The objective of this study was to evaluate the effect of recombinant human bone morphogenetic protein-4 (rhBMP-4) dose on local bone formation in a rat calvaria defect model...
  3. ncbi Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth
    O Gauthier
    Laboratoire de Chirurgie, Ecole Nationale Veterinaire de Nantes, France
    Biomaterials 19:133-9. 1998
    ..MBCP implants with 565 microm pore diameter and 40% macroporosity represented the optimal association for homogeneous and abundant bone ingrowth...
  4. ncbi Comparative study of tissue reactions to calcium phosphate ceramics among cancellous, cortical, and medullar bone sites in rabbits
    J X Lu
    Institut de Recherche sur les Maladies du Squelette, Berck sur Mer, France
    J Biomed Mater Res 42:357-67. 1998
    ....
  5. pmc Bone regeneration: molecular and cellular interactions with calcium phosphate ceramics
    Florence Barrere
    Biomedical Technological Institute BMTI, University ofTwente, Enschede, The Netherlands
    Int J Nanomedicine 1:317-32. 2006
    ....
  6. ncbi Calcium phosphate cements as bone drug delivery systems: a review
    M P Ginebra
    Biomedical Engineering Research Centre, Department of Materials Science and Metallurgical Engineering, Technical University of Catalonia, 08028 Barcelona, Spain
    J Control Release 113:102-10. 2006
    ..In this article, the performance of calcium phosphate cements as carriers of different types of drugs, such as antibiotics, analgesics, anticancer, anti-inflammatory, as well as growth factors is reviewed...
  7. ncbi Calcium phosphate composite layers for surface-mediated gene transfer
    Ayako Oyane
    Nanosystem Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
    Acta Biomater 8:2034-46. 2012
    ..These composite layers, given their good biocompatibility and the potential to control cell behavior on their surfaces, have great potential in tissue engineering applications...
  8. ncbi A combination of calcium phosphate and probiotics beneficially influences intestinal lactobacilli and cholesterol metabolism in humans
    Ulrike Trautvetter
    Department of Nutritional Physiology, Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Str 24, D 07743 Jena, Germany
    Clin Nutr 31:230-7. 2012
    ..The study focuses on the influence of a probiotic supplement alone and in combination with a calcium supplement on faecal lactobacilli colonisation and beneficial health effects such as a lowering of blood cholesterol...
  9. ncbi Surface-mediated gene transfer from nanocomposites of controlled texture
    Hong Shen
    School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, USA
    Nat Mater 3:569-74. 2004
    ..DNA/mineral nanocomposite surfaces represent a promising system for enhancing gene transfer and controlling the extent of gene transfer for various biomedical applications, including tissue engineering or gene therapy of bone...
  10. ncbi The combined bone forming capacity of human periosteal derived cells and calcium phosphates
    Scott J Roberts
    Laboratory for Skeletal Development and Joint Disorders, Katholieke Universiteit Leuven, Belgium
    Biomaterials 32:4393-405. 2011
    ..This study demonstrates the importance of matching a cell support/biological matrix with a cell type and subsequently has outlined parameters which can be used for the rational selection of biomaterials for bone engineering...
  11. ncbi Calcium phosphate coated electrospun fiber matrices as scaffolds for bone tissue engineering
    Anandkumar Nandakumar
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, PO Box 217, 7500 AE, The Netherlands
    Langmuir 26:7380-7. 2010
    ..The results of this study showed that the biomimetic method can successfully be used to coat electrospun scaffolds with a calcium phosphate layer, which improved the in vivo bioactivity of the polymer...
  12. ncbi Osteoinduction by biomaterials--physicochemical and structural influences
    Pamela Habibovic
    Department Bilthoven, Institute for Biomedical Technology, University of Twente, Professor Bronkhorstlaan 10 D, Bilthoven, 3723 MB, The Netherlands
    J Biomed Mater Res A 77:747-62. 2006
    ....
  13. ncbi Dose-dependent osteogenic effect of octacalcium phosphate on mouse bone marrow stromal cells
    Takahisa Anada
    Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Sendai, Japan
    Tissue Eng Part A 14:965-78. 2008
    ....
  14. ncbi Osteogenicity of biphasic calcium phosphate ceramics and bone autograft in a goat model
    Borhane H Fellah
    INSERM U791, Laboratory for Osteoarticular and Dental Tissue Engineering, Faculty of Dental Surgery, 1 Place Alexis Ricordeau, Nantes, France
    Biomaterials 29:1177-88. 2008
    ..4+/-3.7% initially to 1.7+/-1.2% at 12 weeks). This study shows that synthetic bone substitutes may have superior stability and osteogenic properties than autologous bone grafts in critical-sized bone defects...
  15. ncbi Annexin 5 overexpression increased articular chondrocyte apoptosis induced by basic calcium phosphate crystals
    H K Ea
    INSERM U606, IFR 139, Hopital Lariboisiere, Paris, France
    Ann Rheum Dis 67:1617-25. 2008
    ..We assessed in vitro whether BCP crystals and overexpression of A5 increased chondrocyte apoptosis...
  16. ncbi Effect of calcium phosphate cements on growth and odontoblastic differentiation in human dental pulp cells
    Sun Kyung Lee
    Department of Oral and Maxillofacial Pathology and Institute of Wonkwang Biomaterials Implant, School of Dentistry, Wonkwang University, Iksan, Korea
    J Endod 36:1537-42. 2010
    ..The purpose of this study was to investigate the effects of CPCs on the mechanical properties, growth, and odontoblastic differentiation in HDPCs compared with Portland cement (PC) and mineral trioxide aggregate (MTA)...
  17. ncbi Paracrine effect of canine allogenic umbilical cord blood-derived mesenchymal stromal cells mixed with beta-tricalcium phosphate on bone regeneration in ectopic implantations
    Ye Eun Byeon
    Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University, Seoul, Korea
    Cytotherapy 12:626-36. 2010
    ..The aim of this study was to evaluate the paracrine effects of canine umbilical cord blood (cUCB) mesenchymal stromal cells (MSC) mixed with beta-tricalcium phosphate (beta-TCP) on bone regeneration in ectopic implantation...
  18. ncbi Basic calcium phosphate crystals induce monocyte/macrophage IL-1β secretion through the NLRP3 inflammasome in vitro
    Borbála Pazár
    Department of Rheumatology, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    J Immunol 186:2495-502. 2011
    ..Furthermore, we speculate that IL-1 blockade could be a novel strategy to inhibit BCP-induced inflammation in human disease...
  19. pmc Bone substitutes in vertebroplasty
    P F Heini
    Department of Orthopaedic Surgery, Spine Service, Inselspital, University of Bern, Switzerland
    Eur Spine J 10:S205-13. 2001
    ..Animal studies confirm their biocompatibility and osteoconductivity. However, handling problems and the limited radiopacity of these cements currently preclude their clinical use...
  20. ncbi Influence of β-tricalcium phosphate granule size and morphology on tissue reaction in vivo
    Shahram Ghanaati
    Institute of Pathology, REPAIR Laboratory, Johannes Gutenberg University Mainz, 55101 Mainz, Germany
    Acta Biomater 6:4476-87. 2010
    ..This study demonstrates that variations in the physical properties of a bone substitute material clearly influence the (extent of the) inflammatory reaction and its consequences...
  21. ncbi Calcification of articular cartilage in human osteoarthritis
    M Fuerst
    Department of Orthopaedic Surgery, University Medical Center Hamburg Eppendorf, Clinic Bad Bramstedt, Martinistrasse 52, Hamburg, Germany
    Arthritis Rheum 60:2694-703. 2009
    Hypertrophic chondrocyte differentiation is a key step in endochondral ossification that produces basic calcium phosphates (BCPs)...
  22. ncbi The performance of BMP-2 loaded TCP/HAP porous ceramics with a polyelectrolyte multilayer film coating
    Thomas Crouzier
    LMGP, UMR 5628 CNRS INPG, 3 parvis Louis Neel, 38016 Grenoble, France
    Biomaterials 32:7543-54. 2011
    ..This opens perspective for coating these bioactive PEM on other types of implantable materials, including metal alloy that do not exhibit any affinity for rhBMP-2...
  23. ncbi A comparative study of biphasic calcium phosphate ceramics for human mesenchymal stem-cell-induced bone formation
    T Livingston Arinzeh
    Osiris Therapeutics, Inc, Baltimore, MD, USA
    Biomaterials 26:3631-8. 2005
    ..In vitro studies also demonstrated that 20/80 HA/TCP stimulated the osteogenic differentiation of hMSCs as determined by the expression of osteocalcin...
  24. ncbi Injectable PLGA microsphere/calcium phosphate cements: physical properties and degradation characteristics
    W J E M Habraken
    Department of Periodontology and Biomaterials, College of Dental Science, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Biomater Sci Polym Ed 17:1057-74. 2006
    ..In conclusion, all physical parameters were well within workable ranges with both 10:90 and 20:80 PLGA microsphere/CaP cements. After 12 weeks the PLGA was totally degraded and a highly porous, but strong scaffold remained...
  25. ncbi Enhanced osteoinduction by controlled release of bone morphogenetic protein-2 from biodegradable sponge composed of gelatin and beta-tricalcium phosphate
    Yoshitake Takahashi
    Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara cho Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Biomaterials 26:4856-65. 2005
    ..These results suggest that the maintenance of the intrasponge space necessary for the osteoinduction is one factor contributing to the osteoinduction extent of BMP-2-incorporating sponges...
  26. ncbi Nanostructured calcium phosphates (NanoCaPs) for non-viral gene delivery: influence of the synthesis parameters on transfection efficiency
    Dana Olton
    Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Biomaterials 28:1267-79. 2007
    ..In addition, X-ray diffraction and Fourier transform infrared spectroscopy analyses confirmed that all of the synthesized CaP structures exhibited the hydroxyapatite phase...
  27. ncbi 3D microenvironment as essential element for osteoinduction by biomaterials
    Pamela Habibovic
    Institute for Biomedical Technology, Twente University, Department Bilthoven, Professor Bronkhorstlaan 10 D, Bilthoven, 3723 MB, The Netherlands
    Biomaterials 26:3565-75. 2005
    ....
  28. ncbi The use of bone-graft substitutes in large bone defects: any specific needs?
    G M Calori
    COR, Orthopaedic Institute, G Pini, University of Milan, Italy
    Injury 42:S56-63. 2011
    ..The purpose of this study was to evaluate the type of materials used and their efficacy for the treatment of large bone defects in traumatology and orthopaedic surgery...
  29. pmc Lipid-coated nano-calcium-phosphate (LNCP) for gene delivery
    Chenguang Zhou
    Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Int J Pharm 392:201-8. 2010
    ....
  30. ncbi Hydrogel-beta-TCP scaffolds and stem cells for tissue engineering bone
    Christian Weinand
    Laboratory for Tissue Engineering and Organ Fabrication, Warren 11 1157, Massachusetts General Hospital, Harvard, Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Bone 38:555-63. 2006
    ..Bone tissue can be successfully formed in vitro using constructs comprised of collagen I hydrogel, MSCs, and porous beta-TCP scaffolds...
  31. ncbi Bone formation using human adipose tissue-derived stromal cells and a biodegradable scaffold
    Hidemi Hattori
    Division of Biomedical Engineering, Research Institute, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Biomed Mater Res B Appl Biomater 76:230-9. 2006
    ..The present results show that ATSCs have a similar ability to differentiate into osteoblasts and to synthesize bone in beta-TCP disk as have BMSCs...
  32. ncbi Fast setting calcium phosphate-chitosan scaffold: mechanical properties and biocompatibility
    Hockin H K Xu
    Paffenbarger Research Center, American Dental Association Foundation, USA
    Biomaterials 26:1337-48. 2005
    ..The highly porous scaffold may facilitate bone ingrowth and implant fixation in vivo. In addition, the two to three times increase in strength may help extend the use of CPC to larger repairs in moderately stress-bearing locations...
  33. ncbi Biomechanical evaluation of vertebroplasty and kyphoplasty with polymethyl methacrylate or calcium phosphate cement under cyclic loading
    Hans Joachim Wilke
    Institute of Orthopaedic Research and Biomechanics, University of Ulm, Ulm, Germany
    Spine (Phila Pa 1976) 31:2934-41. 2006
    ..We developed a new method to simulating in vivo dynamic loading as closely as possible, which allows comparison of kyphoplasty and vertebroplasty, as well as augmentation materials...
  34. ncbi Controlled release of rhBMP-2 loaded poly(dl-lactic-co-glycolic acid)/calcium phosphate cement composites in vivo
    P Q Ruhé
    Department of Biomaterials, Radboud University Nijmegen Medical Center, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    J Control Release 106:162-71. 2005
    ..We conclude that PLGA/Ca-P cement composites can be considered as sustained slow release vehicles and that the release and retention of rhBMP-2 can be modified according to the desired profile to a limited extent...
  35. pmc Induction of macroautophagy by exogenously introduced calcium
    Wentao Gao
    Department of Pathology and Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Autophagy 4:754-61. 2008
    ....
  36. ncbi The induction of bone formation by smart biphasic hydroxyapatite tricalcium phosphate biomimetic matrices in the non-human primate Papio ursinus
    U Ripamonti
    Bone Research Unit, Medical Research Council University of the Witwatersrand, Johannesburg, South Africa
    J Cell Mol Med 12:2609-21. 2008
    ....
  37. ncbi Enhancement of tissue engineered bone formation by a low pressure system improving cell seeding and medium perfusion into a porous scaffold
    Juyong Wang
    Department of Orthopaedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, 113 8519, Japan
    Biomaterials 27:2738-46. 2006
    ..The application of low pressure during the seeding of BMSCs in perfusing medium into a porous scaffold is useful for tissue-engineered bone formation...
  38. ncbi Anterior spinal column augmentation with injectable bone cements
    Jorrit Jan Verlaan
    Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands
    Biomaterials 27:290-301. 2006
    ..In this paper, both vertebroplasty and balloon vertebroplasty and their respective indications, techniques and results are described in relation with the application and limitations of permanent and resorbable injectable bone cements...
  39. ncbi Preparation and properties of g-TTCP/PBS nanocomposites and its in vitro biocompatibility assay
    Rang Rang Fan
    State Key Laboratory of Biotherapy and Cancer Center, Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China
    Int J Biol Macromol 59:227-34. 2013
    ..Cell proliferated well in the extracted solution of the g-TTCP/PBS composites with different g-TTCP content, and there was no necrotic or suspended cells appeared...
  40. ncbi Physico-chemical-mechanical and in vitro biological properties of calcium phosphate cements with doped amorphous calcium phosphates
    Marion Julien
    INSERM, U 791, 1 place A Ricordeau, Nantes, F 44042, France
    Biomaterials 28:956-65. 2007
    ..The total porosity of Mg-CPC was greater compared to Zn-CPC or F-CPC. Osteoblast-like cells, MC3T3-E1, remained viable and maintained their ability to express alkaline phosphatase in contact with the CPCs with doped ACCPs...
  41. ncbi Microporous calcium phosphate ceramics as tissue engineering scaffolds for the repair of osteochondral defects: biomechanical results
    H O Mayr
    Department of Orthopedic and Trauma Surgery, Albert Ludwig University of Freiburg, Freiburg, Germany
    Acta Biomater 9:4845-55. 2013
    ..However, the central area of the implants had a lower ICRS score than healthy cartilage. Microporous TCP was almost fully resorbed at 52 weeks and replaced by bone...
  42. ncbi Cell attachment and response to photocured, degradable bone adhesives containing tricalcium phosphate and purmorphamine
    Kris Gellynck
    Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, 256 Gray s Inn Road, London WC1X 8LD, UK
    Acta Biomater 7:2672-7. 2011
    ..This suggests drug release levels were very low. Purmorphamine and β-TCP incorporation in PPLM adhesives might, therefore, provide prolonged enhancement of in vivo bone repair without systemic drug side-effects...
  43. ncbi Incorporation of bovine serum albumin into biomimetic coatings on titanium with high loading efficacy and its release behavior
    Xiaohua Yu
    Department of Chemical, University of Connecticut, U 3136, Storrs, CT 06269, USA
    J Mater Sci Mater Med 20:287-94. 2009
    ..A much faster release rate would be expected when the coating is implanted in vivo due to the active involvement of osteoclast cells and enzymes...
  44. ncbi Biocompatibility and osteogenicity of degradable Ca-deficient hydroxyapatite scaffolds from calcium phosphate cement for bone tissue engineering
    Han Guo
    Key Laboratory for Ultrafine Materials of Ministry of Education, and Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China
    Acta Biomater 5:268-78. 2009
    ..However, the CDHA scaffolds showed as good biocompatibility and osteogenicity as the hybrid ones at 8 weeks. These results indicate that the CDHA scaffolds fulfill the basic requirements of bone tissue engineering scaffold...
  45. pmc Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: a review
    Susmita Bose
    W M Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164 2920, USA
    Acta Biomater 8:1401-21. 2012
    b>Calcium phosphates (CaPs) are the most widely used bone substitutes in bone tissue engineering due to their compositional similarities to bone mineral and excellent biocompatibility...
  46. ncbi Octacalcium phosphate crystals induce inflammation in vivo through interleukin-1 but independent of the NLRP3 inflammasome in mice
    Sharmal Narayan
    Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Arthritis Rheum 63:422-33. 2011
    ..To determine the mechanisms involved in inflammatory responses to octacalcium phosphate (OCP) crystals in vivo...
  47. ncbi Phosphate: a stealthier killer than previously thought?
    Emilio Gonzalez-Parra
    Nephrology Department, IIS Fundación Jiménez Díaz, Universidad Autonoma de Madrid, Madrid
    Cardiovasc Pathol 21:372-81. 2012
    ....
  48. ncbi Effect of controlled zinc release on bone mineral density from injectable Zn-containing beta-tricalcium phosphate suspension in zinc-deficient diseased rats
    Makoto Otsuka
    Kobe Pharmaceutical University, Department of Pharmaceutical Technology, Motoyama Kitamachi 4 19 1, Higashi Nada, Kobe 658 8558, Japan
    J Biomed Mater Res A 69:552-60. 2004
    ..The results of this study suggest that the local effect on BMD was more pronounced than the effect on the whole body...
  49. ncbi Effect of particle size on zinc release from zinc containing tricalcium phosphate (ZnTCP) in Zn-deficient osteoporosis rats
    Makoto Otsuka
    Kobe Pharmaceutical University, Motoyama Kitamachi, Higashi Nada, Kobe 658 8558, Japan
    Biomed Mater Eng 13:103-13. 2003
    ..In contrast, the AIP for the control decreased after 2 days. The area under the curve of the AIP (AIP-AUC) for 6 days of S-ZnTCP was significantly higher than that of other groups...
  50. ncbi Hydrogel/calcium phosphate composites require specific properties for three-dimensional culture of human bone mesenchymal cells
    J Sohier
    Laboratory for Osteo articular and Dental Tissue Engineering, INSERM U791, University of Nantes, 1 Pl A Ricordeau, 44042 Nantes, France
    Acta Biomater 6:2932-9. 2010
    ..However, the cells did not proliferate nor colonize the constructs, possibly because of a lack of suitable interactions with their micro-environment...
  51. ncbi Beta-tricalcium phosphate/type I collagen cones with or without a barrier membrane in human extraction socket healing: clinical, histologic, histomorphometric, and immunohistochemical evaluation
    Bozidar M B Brkovic
    Clinic of Oral Surgery, Faculty of Dentistry, University of Belgrade, Belgrade, Serbia
    Clin Oral Investig 16:581-90. 2012
    ..A future trial to evaluate the alveolar outcomes at an earlier 6-month time point rather than the 9 months used in this study would be of interest...
  52. ncbi Ectopic bone formation associated with mesenchymal stem cells in a resorbable calcium deficient hydroxyapatite carrier
    Philip Kasten
    Department of Orthopaedic Surgery, University of Heidelberg, Schlierbacher Landstr 200A, 69118 Heidelberg, Germany
    Biomaterials 26:5879-89. 2005
    ..Ectopic bone formation in the novel biomaterial CDHA varied considerably with the cell pool and was at least equal to beta-TCP blocks...
  53. ncbi Evaluation of the ultrasonication process for injectability of hydraulic calcium phosphate pastes
    Mohamed Habib
    Laboratoire de Biomecanique, Département de Génie, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1K 2R1
    Acta Biomater 8:1164-8. 2012
    ..4 ± 2.3% without ultrasonication to 97.3 ± 2.4% with 30%. This result shows that ultrasonication is an effective solution to improve injectability...
  54. ncbi Phenotypic expression of bone-related genes in osteoblasts grown on calcium phosphate ceramics with different phase compositions
    Chaoyuan Wang
    Engineering Research Center in Biomaterials, Sichuan University, Chengdu 610064, China
    Biomaterials 25:2507-14. 2004
    ....
  55. ncbi Ectopic osteogenesis with biphasic ceramics of hydroxyapatite and tricalcium phosphate in rabbits
    K Kurashina
    Department of Dentistry and Oral Surgery, School of Medicine, Shinshu University, Matsumoto, Japan
    Biomaterials 23:407-12. 2002
    ....
  56. ncbi Bone formation and resorption of highly purified beta-tricalcium phosphate in the rat femoral condyle
    Naoki Kondo
    Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, 757 1, Asahimachi Dori, Niigata 951 8510, Japan
    Biomaterials 26:5600-8. 2005
    ..beta-TCP has a good biocompatibility since both bioresorption and bone formation started at an early stage after implantation...
  57. ncbi Ectopic bone formation by microporous calcium phosphate ceramic particles in sheep muscles
    Damien Le Nihouannen
    INSERM EM9903, Osteoarticular and Dental Tissue Engineering, Faculty of Dental Surgery of Nantes, Place Alexis Ricordeau, 44042 Nantes, France
    Bone 36:1086-93. 2005
    ..The different hypotheses explaining ectopic bone formation induced by MBCP granules are discussed. Synthetic bone substitutes with osteoinductive properties could be used in bone reconstructive surgery...
  58. ncbi Initial interaction of U2OS cells with noncoated and calcium phosphate coated titanium substrates
    P J ter Brugge
    Department of Biomaterials, College of Dental Science, University Medical Center Nijmegen, P O Box 9101, The Netherlands
    J Biomed Mater Res 61:399-407. 2002
    ..From this we conclude that the surface characteristics of a material (roughness and composition) can affect the initial interaction of cells with the material...
  59. ncbi Self-setting bioactive calcium-magnesium phosphate cement with high strength and degradability for bone regeneration
    Fan Wu
    Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, People s Republic of China
    Acta Biomater 4:1873-84. 2008
    ....
  60. ncbi Bone formation and degradation of a highly porous biphasic calcium phosphate ceramic in presence of BMP-7, VEGF and mesenchymal stem cells in an ectopic mouse model
    J C Roldán
    Department of Cranio Maxillofacial Surgery, University of Regensburg, Regensburg, Germany
    J Craniomaxillofac Surg 38:423-30. 2010
    ....
  61. ncbi Novel injectable calcium phosphate/chitosan composites for bone substitute materials
    Hua Liu
    Department of Materials Science and Engineering, Jinan University, Guangzhou 510632, People s Republic of China
    Acta Biomater 2:557-65. 2006
    ..The starting material is more readily available and cheaper than HA, poly(methyl methacrylate), and so on. The cement could have good prospects for medical application...
  62. ncbi Ectopic bone formation in adipose-derived stromal cell-seeded osteoinductive calcium phosphate scaffolds
    Jinfeng Yao
    State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, 610044, P R China
    J Biomater Appl 24:607-24. 2010
    ..The ADSCs had a significantly positive effect on the ectopic bone formation. In addition, the usefulness of Micro-CT for the efficient and nondestructive analysis of mineralized bone and calcium phosphate scaffold was confirmed...
  63. ncbi Nanosized and nanocrystalline calcium orthophosphates
    Sergey V Dorozhkin
    Kudrinskaja sq 1 155, Moscow 123242, Russia
    Acta Biomater 6:715-34. 2010
    ..The review also provides possible directions for future research and development...
  64. ncbi Comparative performance of three ceramic bone graft substitutes
    Karin A Hing
    IRC in Biomedical Materials, Queen Mary University of London, London, United Kingdom
    Spine J 7:475-90. 2007
    ..There is, however, a lack of comparative performance data regarding the relative efficacy of these materials when placed in an osseous defect site...
  65. ncbi Control of surface topography in biomimetic calcium phosphate coatings
    Daniel O Costa
    Department of Chemical and Biochemical Engineering, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Canada
    Langmuir 28:3871-80. 2012
    ..Polycaprolactone (PCL) films were coated with calcium phosphates (CaP) by incubation in simulated body fluid (SBF)...
  66. ncbi In vitro elution of vancomycin from calcium phosphate cement
    Tomoyuki Sasaki
    Department of Orthopaedic Surgery, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan
    J Arthroplasty 20:1055-9. 2005
    ..From this study, we concluded that VCM-impregnated CPC might be an effective material for the treatment of osteomyelitis and/or prosthesis infection...
  67. ncbi Influence of calcium phosphate crystal assemblies on the proliferation and osteogenic gene expression of rat bone marrow stromal cells
    Yang Liu
    Biomaterials Unit, School of Dentistry, University of Birmingham, St Chads Queensway, Birmingham B4 6NN, UK
    Biomaterials 28:1393-403. 2007
    b>Calcium phosphates (CaPs) have been investigated as substrates to promote bone formation both in vitro and in vivo...
  68. ncbi An in vivo study of a growth-factor enhanced, cell free, two-layered collagen-tricalcium phosphate in deep osteochondral defects
    Tobias Gotterbarm
    Department of Orthopaedics, University of Heidelberg, Schlierbacher Landstrasse 200a, 69118 Heidelberg, Germany
    Biomaterials 27:3387-95. 2006
    ..In conclusion, the two-layered collagen-TCP implant augmented with chondroinductive growth factors seems a promising new option for the treatment of deep osteochondral defects in joint surgery...
  69. ncbi Bone response and mechanical strength of rabbit femoral defects filled with injectable CaP cements containing TGF-beta 1 loaded gelatin microparticles
    Dennis P Link
    Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Biomaterials 29:675-82. 2008
    ..The results of this study showed that CaP/gelatin composites show excellent osteogenic properties and a rapid increase in mechanical strength. The addition of TGF-beta1 significantly enhances the bone remodeling process...
  70. ncbi Calcium-phosphate-silicate composite bone cement: self-setting properties and in vitro bioactivity
    Zhiguang Huan
    Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai, 200050, People s Republic of China
    J Mater Sci Mater Med 20:833-41. 2009
    ..With good hydraulic properties, improved biocompatibility and moderate degradability, the novel DCPD/C(3)S bone cement may be a potential candidate as bone substitute...
  71. ncbi Tooth root regeneration using dental follicle cell sheets in combination with a dentin matrix - based scaffold
    Bo Yang
    State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, PR China
    Biomaterials 33:2449-61. 2012
    ..Therefore, DFCSs combined with TDM may prove to be a better strategy for the construction of tooth root, and is a prospective approach that could be utilized for the treatment of root or tooth defect or loss in future...
  72. ncbi A prospective, randomized trial for the prevention of mucositis in patients undergoing hematopoietic stem cell transplantation
    A S Papas
    Department of Oral Medicine, Tufts New England Medical Center, Tufts University School of Dental Medicine, Boston, MA 02111, USA
    Bone Marrow Transplant 31:705-12. 2003
    ....
  73. ncbi Silicon-substituted calcium phosphates - a critical view
    Marc Bohner
    RMS Foundation, Bischmattstrasse 12, CH 2544 Bettlach, Switzerland
    Biomaterials 30:6403-6. 2009
    Nowadays, the scientific community widely accepts the statement that silicon-substituted calcium phosphates have better biological properties compared to pure calcium phosphates...
  74. ncbi The chemical composition of synthetic bone substitutes influences tissue reactions in vivo: histological and histomorphometrical analysis of the cellular inflammatory response to hydroxyapatite, beta-tricalcium phosphate and biphasic calcium phosphate cer
    Shahram Ghanaati
    Institute of Pathology, University Medical Center of the Johannes Gutenberg University Mainz, Germany
    Biomed Mater 7:015005. 2012
    ..Both of these factors are necessary for successful bone tissue regeneration...
  75. ncbi Formation of osteoclast-like cells on HA and TCP ceramics
    R Detsch
    BioCer Entwicklungs GmbH, 95447 Bayreuth, Germany
    Acta Biomater 4:139-48. 2008
    ..On the other hand, highly soluble calcium phosphate ceramics like TCP seem to be inappropriate for osteoclast resorption because they produce a high calcium concentration in the osteoclast interface and in the environment...
  76. ncbi Porous beta tricalcium phosphate scaffolds used as a BMP-2 delivery system for bone tissue engineering
    Jerome Sohier
    INSERM, U791, Laboratory for Osteo articular and Dental Tissue Engineering, Faculty of Dental Surgery, University of Nantes, Nantes, France
    J Biomed Mater Res A 92:1105-14. 2010
    ..These results indicate the suitability of chemically etched beta-TCP scaffolds as BMP-2 carriers, in the context of bone regeneration...
  77. ncbi Calcium phosphate cement containing resorbable fibers for short-term reinforcement and macroporosity
    Hockin H K Xu
    Paffenbarger Research Center, American Dental Association Health Foundation, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Biomaterials 23:193-202. 2002
    ..The reinforcement mechanisms appeared to be crack bridging and fiber pullout, the mechanical properties of the CPC matrix also affected the composite properties...
  78. ncbi Superior mineralization and neovascularization capacity of adult human metaphyseal periosteum-derived cells for skeletal tissue engineering applications
    Daoyun Chen
    Department of Orthopaedic Surgery, Shanghai Sixth People s Hospital, Shanghai Jiaotong University, 600 Yishan Road, Shanghai 200233, PR China
    Int J Mol Med 27:707-13. 2011
    ..In conclusion, hMPCs represent a promising cellular candidate for bone tissue engineering...
  79. ncbi The effect of the microstructure of beta-tricalcium phosphate on the metabolism of subsequently formed bone tissue
    Takatoshi Okuda
    Department of Oral Pathology and Bone Metabolism, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Biomaterials 28:2612-21. 2007
    ..These results showed that the microstructure of beta-TCP affects the activity of bone cells and subsequent bone replacement...
  80. ncbi Endocultivation: 3D printed customized porous scaffolds for heterotopic bone induction
    Stephan T Becker
    Department of Oral and Maxillofacial Surgery, Christian Albrechts University Kiel, Germany
    Oral Oncol 45:e181-8. 2009
    ..Further studies should explore if the stability of the individually designed blocks is sufficient to cultivate larger replacements without an external matrix for support...
  81. ncbi Effective transfection of cells with multi-shell calcium phosphate-DNA nanoparticles
    Viktoriya V Sokolova
    Institute of Inorganic Chemistry, University of Duisburg Essen, Universitaetsstrasse 5 7, D 45117 Essen, Germany
    Biomaterials 27:3147-53. 2006
    ..The dispersions were stable and could be used for transfection after 2 weeks of storage at 4 degrees C without loss of efficiency...
  82. pmc Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery
    Jun Li
    Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Control Release 142:416-21. 2010
    ..The untargeted NP showed a very low silencing effect. The new formulation improved the in vitro silencing effect 3-4 folds compared to the previous LPD formulation, but had a negligible immunotoxicity...
  83. ncbi Calcium phosphate nanoparticles as a novel nonviral vector for efficient transfection of DNA in cancer gene therapy
    Ting Liu
    Xiangya Hospital, Central South University, Changsha 410078, Hunan Province, People s Republic of China
    Cancer Biother Radiopharm 20:141-9. 2005
    ..Our results showed that the CPNP might be a potential vector for gene therapy...
  84. ncbi Transfection of adherent and suspended cells by calcium phosphate
    Martin Jordan
    LBTC, Laboratory of Cellular Biotechnology, EPFL, Lausanne Switzerland
    Methods 33:136-43. 2004
    ..Examples of protocols that were established and tested within the authors' laboratory are presented. The article also emphasizes differences between transfections of adherent and suspended cells...
  85. ncbi Calcium phosphate nanoparticles as novel non-viral vectors for targeted gene delivery
    Indrajit Roy
    Department of Chemistry, University of Delhi, Delhi 110007, India
    Int J Pharm 250:25-33. 2003
    ..We have demonstrated in our studies that these surface modified calcium phosphate nanoparticles can be used in vivo to target genes specifically to the liver...
  86. ncbi Tissue-engineered bone using mesenchymal stem cells and a biodegradable scaffold
    Jae Seong Boo
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Nagoya University, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    J Craniofac Surg 13:231-9; discussion 240-3. 2002
    ..The fabricated synthetic bone using biodegradable beta-TCP as a scaffold in vivo is useful for reconstructing bone, because the scaffold material is absorbed several months after implantation...
  87. ncbi Comparative in vivo study of six hydroxyapatite-based bone graft substitutes
    Pamela Habibovic
    University of Twente, Department of Tissue Regeneration, Enschede, The Netherlands
    J Orthop Res 26:1363-70. 2008
    ....
  88. ncbi A novel amorphous calcium phosphate polymer ceramic for bone repair: I. Synthesis and characterization
    A M Ambrosio
    Center for Advanced Biomaterials and Tissue Engineering, Department of Chemical Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, Pennsylvania 19104, USA
    J Biomed Mater Res 58:295-301. 2001
    ..Sintering the composite microspheres together yielded a bioresorbable, porous, 3-dimensional scaffold that may be ideal for tissue ingrowth, making this composite scaffold potentially suitable for bone repair applications...
  89. ncbi Beta-TCP bone graft substitutes in a bilateral rabbit tibial defect model
    William R Walsh
    Surgical and Orthopaedic Research Laboratories, University of New South Wales, Prince of Wales Hospital, L1 Clinical Sciences Building, Sydney 2031, Australia
    Biomaterials 29:266-71. 2008
    ..Vitoss resorbed faster than the other materials and is likely to differences in particle geometry, pore structure and interconnectivity...
  90. ncbi The importance of particle size and DNA condensation salt for calcium phosphate nanoparticle transfection
    Claudio E Pedraza
    Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
    Biomaterials 29:3384-92. 2008
    ..We found that the key parameters for effective calcium phosphate nanoparticle transfection were an optimal concentration of calcium and chloride ions and a nanosized non-agglomerated precipitate...
  91. ncbi Theoretical analysis of calcium phosphate precipitation in simulated body fluid
    Xiong Lu
    Department of Mechanical Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    Biomaterials 26:1097-108. 2005
    ..The effects of carbonate incorporation and calcium deficiency in HA were also estimated with available data. Generally, such apatite precipitations are more kinetically favorable than HA...
  92. ncbi Chondrogenic pre-induction of human mesenchymal stem cells on beta-TCP: enhanced bone quality by endochondral heterotopic bone formation
    Patricia Janicki
    Division of Experimental Orthopaedics, Orthopaedic University Hospital of Heidelberg, Schlierbacher Landstrasse 200a, D 69118 Heidelberg, Germany
    Acta Biomater 6:3292-301. 2010
    ..004) than HA/TCP for human MSC, and chondrogenic priming of beta-TCP/MSC represented a superior approach capable of supporting full bone formation, including marrow organization...
  93. ncbi Repair of segmental bone defects in rabbit tibiae using a complex of beta-tricalcium phosphate, type I collagen, and fibroblast growth factor-2
    Hirokazu Komaki
    Department of Orthopaedic Surgery, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Tokyo, Japan
    Biomaterials 27:5118-26. 2006
    ..In addition, the complex of beta-TCP granules and collagen combined with rhFGF-2 provides a paste-like material that is easy to handle. This material may be of considerable use in the treatment of cortical bone defects...
  94. ncbi Synthetic bone graft substitutes
    W R Moore
    Department of Orthopaedic Surgery, Modbury Public Hospital, Modbury, Australia
    ANZ J Surg 71:354-61. 2001
    ..The benefits of synthetic grafts include availability, sterility and reduced morbidity. The present article examines the relevance of synthetic bone graft substitutes, their mechanical properties and clinical application...
  95. ncbi Repair of canine mandibular bone defects with bone marrow stromal cells and porous beta-tricalcium phosphate
    Jie Yuan
    Shanghai Key Laboratory of Tissue Engineering, Department of Plastic and Reconstructive Surgery, Shanghai 9th People s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhi Zao Ju Road, Shanghai 200011, China
    Biomaterials 28:1005-13. 2007
    ..05). Based on these results, we conclude that engineered bone from osteogenically induced BMSCs and biodegradable beta-TCP can well repair the critical-sized segmental mandibular defects in canines...
  96. ncbi The kinetic and biological activity of different loaded rhBMP-2 calcium phosphate cement implants in rats
    Esther W H Bodde
    Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Biomed Mater Res A 87:780-91. 2008
    ..Low amounts of sustained released rhBMP-2 were sufficient to bridge critically sized defects. A substantial amount of rhBMP-2 was retained in the implants because of the slow release rate and the limited degradation...
  97. ncbi Biological performance of a new beta-TCP/PLLA composite material for applications in spine surgery: in vitro and in vivo studies
    Stephane Aunoble
    Bordeaux 2 University, Spine Unit, 6th Floor, DETERCA Lab, 146 Leo Saignat, Bordeaux 33076, France
    J Biomed Mater Res A 78:416-22. 2006
    ....
  98. ncbi Bone repair in radii and tibias of rabbits with phosphorylated chitosan reinforced calcium phosphate cements
    Xiaohong Wang
    State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, People s Republic of China
    Biomaterials 23:4167-76. 2002
    ..Progressive substitution took place at the interface of implants and host bones. No adverse effects were found in tissues around the bone defects. Thus, they could be used as bone substitutes in clinic...
  99. ncbi Osteogenesis and angiogenesis of tissue-engineered bone constructed by prevascularized β-tricalcium phosphate scaffold and mesenchymal stem cells
    Le Wang
    Institute of Orthopaedics and Traumatology, The Third Affiliated Hospital, Guangzhou Medical University, People s Republic of China
    Biomaterials 31:9452-61. 2010
    ....
  100. ncbi Polymer--calcium phosphate cement composites for bone substitutes
    Rafal A Mickiewicz
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
    J Biomed Mater Res 61:581-92. 2002
    ..The increased strength was attributed to the polymer's capacity to bridge between multiple crystallites (thus forming a more cohesive composite) and to absorb energy through plastic flow...
  101. ncbi A biodegradable porous composite scaffold of PGA/beta-TCP for bone tissue engineering
    Hong Cao
    Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo, Japan
    Bone 46:386-95. 2010
    ..Thus the PGA/beta-TCP composite scaffold, especially weight ratio 1:3, exhibited a strong ability for osteogenesis, mineralization and biodegradation for bone replacement...

Research Grants62

  1. Human Embryonic Stem Cells in Calcium Phosphate Constructs for Bone Regeneration
    HUAKUN XU; Fiscal Year: 2013
    ..However, there has been no report on the use of hESCs for bone tissue engineering via injectable calcium phosphates. While human bone marrow mesenchymal stem cells (hBMSCs) are useful, their harvest requires an invasive ..
  2. Osteogenic Calcium Phosphate Nanoparticles with Designable Drug Release Kinetics
    Vuk Uskoković; Fiscal Year: 2012
    ..The central hypothesis of the proposed study is that stoichiometry and the particle size of calcium phosphates can be used to tune the kinetics of the release of the encapsulated drug. Dr...
  3. Innovation in the Prevention and Treatment of Early Childhood Caries
    Norman Tinanoff; Fiscal Year: 2013
    ..of antimicrobials (sugar alcohols, heavy metal, antiseptics) and remineralizing agents (fluoride, calcium phosphates, therapeutic restorative materials);effect of early interventions in medical settings;and result of delay of ..
  4. High Strength Bioresorbable PLA/CaP Composites
    Tongxin Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bioresorbable composites made from degradable polymers and bioactive calcium phosphates are clinically desirable for bone fixation and repair, because they do not have to be removed by second surgery ..
  5. NANOSTRUCTURED BIOACTIVE MATERIALS
    Laurence Chow; Fiscal Year: 2009
    ..Aim 3 will evaluate the effectiveness of nano sized calcium phosphates and calcium fluoride in reducing dentin permeability, a property closely associated with dental ..
  6. NORMAL & PATHOLOGICAL ENAMEL MINERALIZATION
    Takaaki Aoba; Fiscal Year: 1993
    ..results, we will re-evaluate the degree of saturation of enamel fluid with respect to enamel and other calcium phosphates of interest...
  7. THREE APPROACHES TO RAPID REMINERALIZATION OF THE TOOTH
    Ming Tung; Fiscal Year: 1992
    ..stability of calcium phosphate solution; (2) determine factors affecting the precipitation and maturation of calcium phosphates in the above three kind of solutions: (3) formulate solutions based on the above findings; and (4) test in ..
  8. GORDON RESEARCH CONFERENCE ON CALCIUM PHOSPHATES, 1992
    ROY WUTHIER; Fiscal Year: 1992
    This proposal is submitted to help organize and conduct the 1992 Gordon Research Conference on Calcium Phosphates, to be held July 20 to 24 at Salve Regina College, Newport, Rhode Island...
  9. 2004-2006 Biomineralization Gordon Research Conferences
    Joanna Aizenberg; Fiscal Year: 2006
    ..the Conference include: the structure of the mineral in organs of vertebrates and invertebrates, including calcium phosphates, carbonates, and silica; the properties and function of the matrix proteins found in mineralized tissues; ..
  10. GORDON RESEARCH CONFERENCE ON BIOMINERALIZATION
    STEPHEN WEINER; Fiscal Year: 2001
    ..This meeting is a continuation of the Gordon Research Conference on Calcium Phosphates (previously held on alternate years since 1979), organized in a new direction...
  11. KINETICS OF MINERALIZATION OF TEETH
    GEORGE NANCOLLAS; Fiscal Year: 2000
    ..Aggregation and electrophoretic mobility measurements of dentin, calculus, enamel, and synthetic calcium phosphates will be determined in the presence of both simple inorganic ions and separated salivary proteins.
  12. GENOME SEQUENCE OF STREPTOCOCCUS SOBRINUS
    Steven Gill; Fiscal Year: 2001
    ..As acid production is important to the release of calcium phosphates from the tooth enamel, and the subsequent formation of caries, this unique ability of S...
  13. CALCIUM PHOSPHATE COATING FOR ORTHOPEDIC PROSTHESES
    Myron Spector; Fiscal Year: 1993
    ..They expect that this apatite deposition and subsequent bone bonding proceeds at a slower rate than with calcium phosphates more closely resembling bone mineral...
  14. CERAMIC WHISKER REINFORCEMENT OF DENTAL COMPOSITE RESINS
    HUAKUN XU; Fiscal Year: 2002
    ....
  15. TISSUE-CRYSTAL INTERACTION CA OXALATE NEPHROLITHIASIS
    Saeed Khan; Fiscal Year: 2003
    ..We can follow various events of nephrolithiasis in the animal model and cats explore the outcome of renal epithelial cell exposure to oxalate and calcium oxalate crystals in the cell cultures. ..
  16. CaP, crystal responsible for idiopathic nephrolithasis
    Saeed Khan; Fiscal Year: 2008
    ..Type density and size must conform to limits and specifications provided in the PHS 398Instructions. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  17. IMPROVED PREVENTIVE/RESTORATIVE RESINS AND COMPOSITES
    SABINE DICKENS; Fiscal Year: 2006
    ..The data gathered in these experiments will serve to support a larger R01 grant application with the long-term objectives of developing improved durable materials for adhesives and adhesive composites. [unreadable] [unreadable]..
  18. RESIN-BASED REMINERALIZING CEMENTS AND COMPOSITES
    SABINE DICKENS; Fiscal Year: 2009
    ..Completion of this research will lead to Ca- PO4 cements and composites with improved adhesion to dentin and improved strength for ART and the treatment of root caries. ..
  19. EFFECTS OF ACID ON BONE
    David A Bushinsky; Fiscal Year: 2010
    ..The current proposal is aimed at understanding the first steps by which acid is detected by bone cells. Understanding the process by which the bone detects and neutralizes the acid can lead to an improvement in bone health. ..
  20. Novel DNA Delivery via Surface Bound Calcium Phosphates
    Jian Tan; Fiscal Year: 2008
    ..The technology developed in this proposal will have important impact on basic research, biotech industry and gene therapy based medicine. [unreadable] [unreadable] [unreadable]..
  21. IKSI: 1st Annual International Urolithiasis Research Symposium
    Andrew Evan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  22. IKSI: 2nd International Urolithiasis Research Symposium
    Andrew Evan; Fiscal Year: 2008
    ..This assumption was supported by the great success of the 1st International Urolithiasis Research symposium and the high level of interest in the 2nd symposium date. [unreadable] [unreadable] [unreadable]..
  23. Risk for Renal Injury Caused by Shock Wave Lithotripsy
    Andrew Evan; Fiscal Year: 2008
    ..All of these proposed studies aim at understanding the adverse effects of shock waves and advancing the safety of all stone patients at a time when reports of adverse effects in SWL are on the rise. ..
  24. TEM with Digital and Cryopreparation Systems
    Andrew Evan; Fiscal Year: 2003
    ..Dr. Richard Gregory will employ immunohistochemistry to examine the role of a Streptococcus mutans 65 kDa fimbrial protein binding as a mechanism for the induction of dental carries. ..
  25. Biomimetic Synthesis of an Enamel-Like Material
    Stefan Habelitz; Fiscal Year: 2004
    ..abstract_text> ..
  26. GROWTH PLATE CELLULAR FUNCTION FOLLOWING RADIOTHERAPY
    Timothy Damron; Fiscal Year: 2008
    ..abstract_text> ..
  27. MATRIX GLA PROTEIN AND CARTILAGE CALCIFICATION
    Paul Price; Fiscal Year: 2001
    ..The investigators will further study the demonstrated ability of MGP to inhibit calcification in supersaturated solutions, and will investigate the ability of MGP to inhibit matrix vesicle -initiated calcification. ..
  28. Bone-Sparing by Ca Salts With & Without Extra Phosphorus
    Robert Heaney; Fiscal Year: 2008
    ..1 Description, ..
  29. BONY EFFECTS OF TRANSIENT NONSKELETAL ILLNESS
    Robert Heaney; Fiscal Year: 2001
    ....
  30. Development of a P.gingivalis vaccine
    Eric Reynolds; Fiscal Year: 2006
    ..The recombinant proteins, protein fragments and synthetic peptide multivalent constructs will be tested as defined vaccines against P. gingivalis in murine models of disease. ..
  31. Initiation and Inhibition of Medial Artery Calcification
    Paul Price; Fiscal Year: 2008
    ..abstract_text> ..
  32. Impact of Oral bacterial interactions on periodontitis
    Eric Reynolds; Fiscal Year: 2004
    ..gingivalis, T. denticola, B. forsythus and F. nucleatum grown in monoculture and as polymicrobial cultures using 2D-gel electrophoresis, mass spectrometry and Western blotting. ..
  33. PREVENTION OF DENTAL CARIES
    Shozo Takagi; Fiscal Year: 2005
    ....
  34. Regulation of Cranial Suture Development by TGF-Beta and Fibroblast Growth Factor
    Arun Gosain; Fiscal Year: 2007
    ..This proposal will provide mechanistic insights into the regulation of cranial suture development, and help to relate mouse and human models of craniosynostosis. ..
  35. Sensate Scaffolds for Orthopaedic Tissue Repair
    John Szivek; Fiscal Year: 2005
    ..A system of this type will provide a means of monitoring healing and rehabilitation in patients. ..
  36. TRANSGLUTAMINASE PROMOTES CPPD DISEASE IN AGING JOINTS
    Ann Rosenthal; Fiscal Year: 2007
    ..These studies will contribute to our understanding of CPPD deposition disease, so that effective therapies for this common and disabling form of arthritis can be designed. ..
  37. Role of Biopolymers and Lipids in Kidney Stone Formation
    LAURIE GOWER; Fiscal Year: 2004
    ..The long-range clinical goal of this BRP is to provide a more effective means of diagnosis, treatment, and long-term prevention of renal calculi. ..
  38. Formation of the Enamel-Dentin Interface
    Elia Beniash; Fiscal Year: 2010
    ..abstract_text> ..
  39. Aging-Related Models and Mitochondrial Bioenergetics
    David Nicholls; Fiscal Year: 2006
    ..3. To indicate therapeutic strategies whereby the deleterious consequences of aging-related changes in mitochondrial function can be minimized. ..
  40. MECHANISM OF HARD TISSUE MINERALIZATION
    Adele L Boskey; Fiscal Year: 2010
    ..Aim 3: To determine whether DSPP and BGN interact synergistically during the collagen-based in vitro mineralization process using in vitro and in situ analyses. ..
  41. Synovium-based articular cartilage tissue engineering
    Ernst B Hunziker; Fiscal Year: 2010
    ..We believe that this project is highly innovative and that the results of this research will have a significant impact on the future treatment of osteoarthritic lesions and on improvement of the health status of the US population. ..
  42. Microbial Outcomes of Minimal Intervention Treatment
    Mathilde Peters; Fiscal Year: 2005
    ..This investigation is a clinical and molecular re-entry study of sealing of caries, in support of a future full-scale clinical trial of incomplete caries removal. ..
  43. A NEW STRATEGY FOR AMELOGENIN CYRSTALLIZATION
    JANET OLDAK; Fiscal Year: 2004
    ..abstract_text> ..
  44. Bladder-specific Knockout and Gene Expression
    Xue ru Wu; Fiscal Year: 2009
    ..These studies will generate powerful experimental tools for studying bladder biology and diseases and offer molecular insights regarding urothelial growth and tumorigenesis. ..
  45. IN VITRO INITIATION OF BIOLOGICAL CALCIFICATION
    Adele Boskey; Fiscal Year: 2009
    ....
  46. Matrix proteins promote matrix vesicle mineralization
    Ann Rosenthal; Fiscal Year: 2007
    ..The ultimate goal of this work is to understand the pathogenesis of calcium crystal formation in articular cartilage, so that specific therapies for this disabling disease can be designed. ..
  47. Osteoporosis in Hypercalciuric Kidney Stone Formers
    John Asplin; Fiscal Year: 2003
    ..We hope to use the algorithm developed in this research to expand out services to include bone disease management in kidney stone forming patients and their families. ..
  48. Helical Rosette Nanotubes for Treating Osteoporotic Bone
    Thomas Webster; Fiscal Year: 2008
    ..abstract_text> ..
  49. Cardiac Outcomes Associated with Renal Osteodystrophy
    Bryan Kestenbaum; Fiscal Year: 2007
    ..The proposed study aims to shed light on the relationship between a common renal related metabolic disorder and the epidemic burden of CVD found among this patient population. ..
  50. Development of a Multi-phased Scaffold for Soft Tissue to Bone Integration
    Helen Lu; Fiscal Year: 2006
    ..abstract_text> ..
  51. Biomaterials (Mg/Zn/F-BCPs)for osteoporosis therapy
    Racquel LeGeros; Fiscal Year: 2006
    ..Hypothesis: Biomaterials with Zn, Mg and F ions in a calcium phosphate matrix (used as dietary supplement and ion releasing injectible 'implants') will improve bone health. ..
  52. ENGINEERING AN OROFACIAL BONE REGENERATIVE THERAPY
    Jeffrey Hollinger; Fiscal Year: 2002
    ..The composition will be administered to mandibular continuity defects to test the general hypothesis and analyses will involve clinical and morphometric methodologies. ..
  53. Signaling activities of amelogenin gene splice products.
    Arthur Veis; Fiscal Year: 2006
    ..In this revision, more experimental details have been provided. ..
  54. Micro-computed tomography system (Micro-CT)
    Adele Boskey; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..