cadmium chloride

Summary

Summary: A cadmium halide in the form of colorless crystals, soluble in water, methanol, and ethanol. It is used in photography, in dyeing, and calico printing, and as a solution to precipitate sulfides. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Top Publications

  1. ncbi Overexpression of the regulatory subunit of gamma-glutamylcysteine synthetase in HeLa cells increases gamma-glutamylcysteine synthetase activity and confers drug resistance
    S R Tipnis
    Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, U K
    Biochem J 337:559-66. 1999
  2. ncbi In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride
    George Fotakis
    Pharmacy Department, King's College London, UK
    Toxicol Lett 160:171-7. 2006
  3. ncbi Particle size-dependent total mass deposition in lungs determines inhalation toxicity of cadmium chloride aerosols in rats. Application of a multiple path dosimetry model
    Flemming R Cassee
    National Institute of Public Health and Environment RIVM, Laboratory of Health Effects Research, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Arch Toxicol 76:277-86. 2002
  4. ncbi Reversal of cadmium chloride-induced oxidative stress and genotoxicity by Adhatoda vasica extract in Swiss albino mice
    Tamanna Jahangir
    Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi 110062, India
    Biol Trace Elem Res 111:217-28. 2006
  5. ncbi Lipid peroxidation and HSP72/73 expression in rat following cadmium chloride administration: interactions of magnesium supplementation
    Manel Boujelben
    , BP. 802-3018 Sfax, Tunisie
    Exp Toxicol Pathol 57:437-43. 2006
  6. ncbi Cadmium chloride-induced oxidative stress in skeletal muscle cells in vitro
    Claudia Lumy Yano
    , Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, CP 6109, 13083-970, Campinas, , SP, Brazil
    Free Radic Biol Med 39:1378-84. 2005
  7. ncbi Dithiocarbamate fungicide thiram detection: comparison of bioluminescent and fluorescent whole-cell bioassays based on hsp22 stress promoter induction
    C A Mandon
    Laboratoire de Genie Enzymatique et Biomoleculaire, UMR 5013 CNRS, Universite Claude Bernard Lyon 1, Villeurbanne, France
    J Biotechnol 124:392-402. 2006
  8. ncbi Rapid and highly sensitive detection of cadmium chloride induced cytotoxicity using the HSP70B' promoter in live cells
    Ken-Ichi Wada
    Bionic Materials Technology Group, Biomaterials Center, National Institute for Materials Science, Tsukuba, Ibaraki, Japan
    Biotechnol Bioeng 92:410-5. 2005
  9. ncbi Antigenotoxic effect of mangiferin and changes in antioxidant enzyme levels of Swiss albino mice treated with cadmium chloride
    E Kasi Viswanadh
    Division of Biotechnology, Manipal Life Sciences Centre, Manipal University, Manipal, India
    Hum Exp Toxicol 29:409-18. 2010
  10. ncbi Pluchea lanceolata attenuates cadmium chloride induced oxidative stress and genotoxicity in Swiss albino mice
    Tamanna Jahangir
    Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University, Hamdard Nagar, New Delhi 110062, India
    J Pharm Pharmacol 57:1199-204. 2005

Research Grants

  1. OXIDANT HEPATIC INJURY IN CHOLESTASIS
    Ronald Sokol; Fiscal Year: 2000
  2. OXIDANT HEPATIC INJURY IN CHOLESTASIS
    Ronald Sokol; Fiscal Year: 1993
  3. TRANSPORT MECHANISMS IN CORNEAL ENDOTHELIUM
    Jorge Fischbarg; Fiscal Year: 2004
  4. HEAVY METALS AND POLYDRUG SELF-ADMINISTRATION
    Jack Nation; Fiscal Year: 2005
  5. Heavy Metal and Drug Self-Administration: Mechanisms
    Paul Wellman; Fiscal Year: 2007
  6. TRANSPORT AND TOXICITY OF MERCURY IN THE NEPHRON
    RUDOLFS ZALUPS; Fiscal Year: 2006
  7. SYNAPTIC VESICLE TRAFFICKING IN HIPPOCAMPAL SYNAPSES
    Venkatesh N Murthy; Fiscal Year: 2010
  8. Metallothionein, Environment Insult and Bladder Cancer
    Donald Sens; Fiscal Year: 2005
  9. Metallothionein Isoform 3 as a Urinary Marker for Bladder Cancer
    Donald Sens; Fiscal Year: 2007
  10. The Causes and Consequences of Complementation and Selfishness in Viruses
    Sarah Joseph; Fiscal Year: 2007

Detail Information

Publications190 found, 100 shown here

  1. ncbi Overexpression of the regulatory subunit of gamma-glutamylcysteine synthetase in HeLa cells increases gamma-glutamylcysteine synthetase activity and confers drug resistance
    S R Tipnis
    Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, U K
    Biochem J 337:559-66. 1999
    ..we have demonstrated for the first time a potential role for GCSl in resistance towards doxorubicin and cadmium chloride. Addition of recombinant GCSl to HeLa cell extracts in vitro was found to result in an increase in GCS ..
  2. ncbi In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride
    George Fotakis
    Pharmacy Department, King's College London, UK
    Toxicol Lett 160:171-7. 2006
    ..Two hepatoma cell lines, namely HTC and HepG2 cells, were exposed to cadmium chloride (0-300 microM) for 3, 5 and 8 h...
  3. ncbi Particle size-dependent total mass deposition in lungs determines inhalation toxicity of cadmium chloride aerosols in rats. Application of a multiple path dosimetry model
    Flemming R Cassee
    National Institute of Public Health and Environment RIVM, Laboratory of Health Effects Research, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Arch Toxicol 76:277-86. 2002
    ..Anjilvel and B. Asgharian (1995, Fundam Appl Toxicol 28:41-50). This paper describes studies using cadmium chloride (CdCl(2)) as a model for toxic aerosol particles to (1) investigate the role of particle size in the ..
  4. ncbi Reversal of cadmium chloride-induced oxidative stress and genotoxicity by Adhatoda vasica extract in Swiss albino mice
    Tamanna Jahangir
    Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi 110062, India
    Biol Trace Elem Res 111:217-28. 2006
    ..In the present study, we evaluated the antioxidant and anticlastogenic efficacy of A. vasica against cadmium chloride (CdCl2)-induced renal oxidative stress and genotoxicity in Swiss albino mice...
  5. ncbi Lipid peroxidation and HSP72/73 expression in rat following cadmium chloride administration: interactions of magnesium supplementation
    Manel Boujelben
    , BP. 802-3018 Sfax, Tunisie
    Exp Toxicol Pathol 57:437-43. 2006
    ..These results were not modified by Mg injections. CONCLUSION: Mg supplementation can reduce Cd accumulation in organs and lipid peroxidation related to Cd administration...
  6. ncbi Cadmium chloride-induced oxidative stress in skeletal muscle cells in vitro
    Claudia Lumy Yano
    , Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, CP 6109, 13083-970, Campinas, , SP, Brazil
    Free Radic Biol Med 39:1378-84. 2005
    The effects of cadmium chloride (CdCl(2)) on oxidative stress in the skeletal muscle cell line C(2)C(12) were investigated. Myoblast cells that differentiated into myotubes were treated with CdCl(2) (1, 3, 5, 7.5, 10, and 12...
  7. ncbi Dithiocarbamate fungicide thiram detection: comparison of bioluminescent and fluorescent whole-cell bioassays based on hsp22 stress promoter induction
    C A Mandon
    Laboratoire de Genie Enzymatique et Biomoleculaire, UMR 5013 CNRS, Universite Claude Bernard Lyon 1, Villeurbanne, France
    J Biotechnol 124:392-402. 2006
    ..Well characterized toxicants, cadmium chloride and thiram (a dithiocarbamate fungicide), were used to optimize the detection conditions such as time-course ..
  8. ncbi Rapid and highly sensitive detection of cadmium chloride induced cytotoxicity using the HSP70B' promoter in live cells
    Ken-Ichi Wada
    Bionic Materials Technology Group, Biomaterials Center, National Institute for Materials Science, Tsukuba, Ibaraki, Japan
    Biotechnol Bioeng 92:410-5. 2005
    ..the heat shock protein 70B' (HSP70B') gene could be used as a functional promoter to detect cytotoxicity of cadmium chloride. We thus detected cytotoxicity induced by cadmium chloride with the luciferase assay using this functional ..
  9. ncbi Antigenotoxic effect of mangiferin and changes in antioxidant enzyme levels of Swiss albino mice treated with cadmium chloride
    E Kasi Viswanadh
    Division of Biotechnology, Manipal Life Sciences Centre, Manipal University, Manipal, India
    Hum Exp Toxicol 29:409-18. 2010
    ..In this study, the protective role of MGN against cadmium chloride (CdCl(2))-induced genotoxicity was studied in Swiss albino mice...
  10. ncbi Pluchea lanceolata attenuates cadmium chloride induced oxidative stress and genotoxicity in Swiss albino mice
    Tamanna Jahangir
    Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University, Hamdard Nagar, New Delhi 110062, India
    J Pharm Pharmacol 57:1199-204. 2005
    ..At 24 h after treatment with a single intraperitoneal dose of cadmium chloride (5 mg kg-1), Swiss albino mice showed a significant increase in the levels of malanodialdehyde and xanthine ..
  11. ncbi Chemical stress sensitive luminescent human cells: molecular biology approach using inducible Drosophila melanogaster hsp22 promoter
    C A Mandon
    , UMR 5013 CNRS, , 69 622 Villeurbanne Cedex, France
    Biochem Biophys Res Commun 335:536-44. 2005
    ..As a result, in the presence of 20-100 microM cadmium chloride, a 6-fold increase in luciferase expression was obtained using a specially designed truncated hsp22 promoter ..
  12. ncbi Cadmium concentrations in the testes, sperm, and spermatids of mice subjected to long-term cadmium chloride exposure
    G Bench
    Center for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, Livermore, California 94550, USA
    Cytometry 35:30-6. 1999
    ..The purpose of this study was to determine whether mice subjected to long-term intraperitoneal cadmium exposure incorporated cadmium into their sperm chromatin...
  13. ncbi Cadmium chloride-induced DNA and lysosomal damage in a hepatoma cell line
    George Fotakis
    Department of Pharmacy, Franklin Wilkins Building, 150 Stamford Street, King's College London, London SE1 8WA, UK
    Toxicol In Vitro 19:481-9. 2005
    ..The aim of this study was to investigate the biochemical effects of cadmium chloride in a rat hepatoma cell line (HTC cells) and the cellular events mediating DNA damage...
  14. ncbi Is cadmium chloride-induced inter-sertoli tight junction permeability barrier disruption a suitable in vitro model to study the events of junction disassembly during spermatogenesis in the rat testis?
    N P Chung
    The Population Council, Center for Biomedical Research, New York, New York 10021, USA
    Endocrinology 142:1878-88. 2001
    ..Based on these results, it is apparent that CdCl(2)-induced inter-Sertoli TJ disassembly is a potential in vitro model to study the events of junction disassembly...
  15. ncbi Arsenic induces expression of the multidrug resistance-associated protein 2 (MRP2) gene in primary rat and human hepatocytes
    L Vernhet
    Institut National de la Sante et de la Recherche Medicale U456, Detoxication et Reparation Tissulaire, Faculte des Sciences Pharmaceutiques et Biologiques, Universite de Rennes I, Rennes, France
    J Pharmacol Exp Ther 298:234-9. 2001
    ..rat hepatocytes by sodium arsenite [As(III)], sodium arsenate and potassium antimony tartrate, but not cadmium chloride, was shown to markedly increase MRP2 mRNA and protein levels; As(III)-mediated induction was dose- and time-..
  16. ncbi Tumor necrosis factor-alpha-null mice are not resistant to cadmium chloride-induced hepatotoxicity
    Eric B Harstad
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Appl Pharmacol 179:155-62. 2002
    ..No significant increase in caspase-3 activity was detected in any of the Cd-treated mice. These data indicate that, in contrast to LPS/Gln-induced hepatotoxicity, TNF-alpha does not appear to mediate Cd-induced hepatotoxicity...
  17. ncbi Morphological characterisation of BGM (Buffalo Green Monkey) cell line exposed to low doses of cadmium chloride
    D Romero
    Department of Toxicology, School of Veterinary Medicine, University of Murcia, Espinardo Campus, E-30100, Murcia, Spain
    Toxicol In Vitro 17:293-9. 2003
    ..062 mM, equivalent to EC(10)-effective concentration 10%) of cadmium chloride have been evaluated...
  18. ncbi Cadmium exposure modifies lactotrophs activity associated to genomic and morphological changes in rat pituitary anterior lobe
    Ana Maria Calderoni
    Laboratorio de Quimica Biologica, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, IMIBIO SL CONICET, Avenida Ejercito de los Andes 950, D5700HHW San Luis, Argentina
    Biometals 23:135-43. 2010
    ..Cd modifies the lactotrophs activity of pituitary gland through biochemical, genomic and morphological changes and contributes directly or indirectly to the levels of serum prolactin...
  19. ncbi Eukaryotic translation initiation factor 4E is a cellular target for toxicity and death due to exposure to cadmium chloride
    Sreekumar Othumpangat
    Molecular Carcinogenesis Laboratory, Toxicology and Molecular Biology Branch, Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Biol Chem 280:25162-9. 2005
    ..Exposure of human cell lines, HCT15, PLC/PR/5, HeLa, and Chang, to cadmium chloride resulted in cytotoxicity and cell death, and this was associated with a significant decrease in eIF4E protein ..
  20. ncbi Induction of micronuclei and binuclei in blood, gill and liver cells of fishes subchronically exposed to cadmium chloride and copper sulphate
    Tolga Cavas
    Department of Biology, Faculty of Sciences and Letters, Mersin University, Ciftlikkoy, 33342 Mersin, Turkey
    Food Chem Toxicol 43:569-74. 2005
    ..The suitability of the micronucleus assay in native fish species for the screening of aquatic genotoxicants is highlighted and the importance of target tissue selection in the piscine micronucleus test is emphasized...
  21. ncbi Applications of gene arrays in environmental toxicology: fingerprints of gene regulation associated with cadmium chloride, benzo(a)pyrene, and trichloroethylene
    M Bartosiewicz
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Environ Health Perspect 109:71-4. 2001
    ..proteins, cytokines, and housekeeping genes to examine gene expression patterns in the liver in response to cadmium chloride, benzo(a)pyrene (BaP), and trichloroethylene (TCE)...
  22. ncbi Expression of hsp 27, hsp 60, hsc 70, and hsp 70 by immortalized human proximal tubule cells (HK-2) following exposure to heat shock, sodium arsenite, or cadmium chloride
    D Kim
    Program in Genetics and Developmental Biology, West Virginia University, Morgantown 26506-9251, USA
    J Toxicol Environ Health A 63:475-93. 2001
    ..was determined in immortalized human proximal tubule cells (HK-2) exposed to heat shock, sodium arsenite, or cadmium chloride (CdCl2) under both acute and extended conditions of exposure...
  23. ncbi Cytotoxicity and transcriptional activation of stress genes in human liver carcinoma cells (HepG2) exposed to cadmium chloride
    P B Tchounwou
    NIH-Center for Environmental Health, School of Science and Technology, Jackson State University, MS 39217, USA
    Mol Cell Biochem 222:21-8. 2001
    ..In this research, we performed the MTT assay for cell viability to assess the cytotoxicity of cadmium chloride (CdCl2), and the CAT-Tox (L) assay to measure the induction of stress genes in thirteen different recombinant ..
  24. ncbi [Activity of 5-aminolevulinate synthase in rat liver during degradation of cytochrome P-450 caused by administration of cadmium chloride]
    P A Kaliman
    Karazin Kharkov National University, Ukraine, Kharkiv
    Ukr Biokhim Zh 75:99-102. 2003
    ..Preliminary administration of alpha-tocopherol prevented changes of studied parameters 24 h after CdCl2 administration. The relationship between decrease of cytochrome P-450 level and 5-aminolevulinate synthase activation are discussed...
  25. ncbi Effects of zinc and cadmium on HgCl2-delta-ALA-D inhibition and Hg levels in tissues of suckling rats
    Nilce C Peixoto
    , , Universidade Federal de Santa Maria, , 97105-900 Santa Maria, RS, Brazil
    Toxicol Lett 146:17-25. 2003
    ..Although the MT is rich in cysteine (-SH) and consequently can form a great number of MT-Hg complex, other mechanisms should be also involved in zinc protection on mercury toxicity...
  26. ncbi Rat liver glutathione S-transferase activity stimulation following acute cadmium or manganese intoxication
    Elisabetta Casalino
    Sezione di Chimica e Biochimica Veterinaria del Dipartimento Farmaco-Biologico, , Str. Prov. per Casamassima, km 3, 70010 Valenzano, Bari, Italy
    Toxicology 200:29-38. 2004
    ..22 microM. The possibility that under the conditions used class alpha GST isoenzymes are affected by cadmium or manganese is discussed...
  27. ncbi A mutant mouse (tx) with increased hepatic metallothionein stability and accumulation
    J Koropatnick
    Department of Oncology, University of Western Ontario, London, Canada
    Biochem J 296:443-9. 1993
    ..These animals may provide a useful model to study the physiological role of MT, and human diseases (such as Wilson's disease) with abnormal copper metabolism...
  28. ncbi Effect of zinc supplementation on bone metabolism in male rats chronically exposed to cadmium
    Malgorzata M Brzóska
    Department of Toxicology, Medical University of Bialystok, Mickiewicza 2c, 15 222 Bialystok, Poland
    Toxicology 237:89-103. 2007
    ..The findings seem to indicate that enhanced dietary intake of Zn in subjects chronically exposed to moderate and relatively high Cd levels may have a protective influence on the skeleton...
  29. ncbi Regulation of ion channel localization and phosphorylation by neuronal activity
    Hiroaki Misonou
    Department of Pharmacology, School of Medicine, University of California, Davis, California 95616, USA
    Nat Neurosci 7:711-8. 2004
    ..Our finding that neuronal activity modifies the phosphorylation state, localization and function of Kv2.1 suggests an important link between excitatory neurotransmission and the intrinsic excitability of pyramidal neurons...
  30. ncbi Effect and mechanism of cadmium on the progesterone synthesis of ovaries
    Wenchang Zhang
    Department of Occupational and Environmental, School of Public Health, Fujian Medical University, Major in Reproduction Toxicology and Enviroment Endocrine Disrupting Chemicals, Fujian, China
    Toxicology 239:204-12. 2007
    ..The mechanisms were mainly controlled by the cAMP-dependent pathway...
  31. ncbi [Heme oxygenase activity in rat organs during cadmium chloride administration]
    I V Nikitchenko
    Karazin Kharkiv National University
    Ukr Biokhim Zh 74:107-11. 2002
    ..However, the increase in the ascorbat-induced LPO in these organs was completely blocked. The role of heme and LPO in the heme oxygenase induction by CdCl2 are discussed...
  32. ncbi Cadmium-induced changes in apoptotic gene expression levels and DNA damage in mouse embryos are blocked by zinc
    Estíbaliz L Fernandez
    Department of Pharmaceutical Biosciences, Division of Toxicology, Biomedical Center, Uppsala University, 75124 Uppsala, Sweden
    Toxicol Sci 76:162-70. 2003
    ..These effects could be ameliorated by zinc pretreatment, and, because of that, it is possible that the mechanisms of cadmium-induced teratogenicity are related to zinc metabolism...
  33. ncbi Effects of diallyl tetrasulfide on cadmium-induced oxidative damage in the liver of rats
    P Murugavel
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India
    Hum Exp Toxicol 26:527-34. 2007
    ..Our results suggest that DTS might play a vital role in protecting Cd-induced oxidative damage in the liver...
  34. ncbi Overexpression of Arabidopsis phytochelatin synthase paradoxically leads to hypersensitivity to cadmium stress
    Sangman Lee
    Department of Natural Resources and Environmental Sciences, University of Illinois, Urbana, Illinois 61801
    Plant Physiol 131:656-63. 2003
    ..Therefore, Cd hypersensitivity in pcs lines seems due to the toxicity of PCs as they existed at supraoptimal levels when compared with GSH levels...
  35. ncbi Effect of metal-based anticancer drugs on wild type and metallothionein null cell lines
    H Mahboobi
    Dipartimento di Scienze e Tecnologie Avanzate, , Corso Borsalino 54, 15100 Alessandria, Italy
    Biometals 16:403-9. 2003
    ..Nonetheless, heavy metal pretreatment of GKA2 cells did not cause any change in their sensitivity...
  36. ncbi The Nrf2 transcription factor contributes to the induction of alpha-class GST isoenzymes in liver of acute cadmium or manganese intoxicated rats: comparison with the toxic effect on NAD(P)H:quinone reductase
    Elisabetta Casalino
    Unit of Veterinary Biochemistry, Department of Pharmaco Biology, University of Bari, Str Prov per Casamassima Km 3, 70010 Valenzano, Bari, Italy
    Toxicology 237:24-34. 2007
    ....
  37. ncbi Effect of cadmium on lymphocyte subsets distribution in thymus and spleen
    A Lafuente
    Laboratorio de Toxicologia, Facultad de Ciencias, Universidad de Vigo, Campus de Orense, Las Lagunas, 32004 Orense, Spain
    J Physiol Biochem 59:43-8. 2003
    ..For this purpose, adult male rats were exposed for one month to 0, 5, 10, 25, 50 or 100 ppm of cadmium chloride (CdCl2) in the drinking water...
  38. ncbi Brain-derived neurotrophic factor facilitates glutamate and inhibits GABA release from hippocampal synaptosomes through different mechanisms
    Nuno Canas
    Laboratory of Neurosciences, Faculty of Medicine, University of Lisbon, Av. Prof. Egas Moniz, Lisbon 1649-028, Portugal
    Brain Res 1016:72-8. 2004
    ..It is concluded that BDNF influences in an opposite way, through distinct mechanisms, the release of glutamate and the release of GABA from hippocampal synaptosomes...
  39. ncbi Increase in intracellular Cd(2+) concentration of rat cerebellar granule neurons incubated with cadmium chloride: cadmium cytotoxicity under external Ca(2+)-free condition
    Yumiko Nishimura
    Laboratory of Cellular Signaling, Faculty of Integrated Arts and Sciences, The University of Tokushima, Minami-Jyosanjima 1-1, Tokushima 770-8502, Japan
    Toxicol In Vitro 20:211-6. 2006
    ..It is suggested that some of cytotoxic actions of CdCl(2) on neurons are unrelated to external Ca(2+), one of main sources for increasing intracellular Ca(2+) concentration...
  40. ncbi Effect of spirulina and Liv-52 on cadmium induced toxicity in albino rats
    K Jeyaprakash
    Department of Biochemistry, Dr NGPArts and Science College, Kovai Medical Center Research and Educational Trust, Coimbatore 641 014, India
    Indian J Exp Biol 43:773-81. 2005
    Oral administration of cadmium (6mg/kg body weight/day) as cadmium chloride (CdCl2) for 30 days resulted in a significant increase in thiobarbituric acid reactive substances (TBARS) level and a decrease in the levels of copper, zinc, iron,..
  41. ncbi Modulation of transmitter release by presynaptic resting potential and background calcium levels
    Gautam B Awatramani
    Oregon Hearing Research Center/Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Neuron 48:109-21. 2005
    ..Together, these studies suggest that control of resting potential is a powerful means for regulating synaptic function at mammalian synapses...
  42. ncbi Acute cadmium intoxication induces alpha-class glutathione S-transferase protein synthesis and enzyme activity in rat liver
    Elisabetta Casalino
    Department of Pharmaco-Biology, Laboratory of Veterinary Biochemistry, University of Bari, Str. Prv. per Casamassima, km 3, 70100 Valenzano, Bari, Italy
    Toxicology 217:240-5. 2006
    ....
  43. ncbi Cadmium, zinc and iron interactions in the tissues of bank vole Clethrionomys glareolus after exposure to low and high doses of cadmium chloride
    Renata Swiergosz-Kowalewska
    Department of Ecotoxicology, Institute of Environmental Sciences, Jagiellonian University, Gronostajowa 7, 30 387, Krakow, Poland
    Biometals 20:743-9. 2007
    ..Cadmium affected the survival and body masses of dosed females. Cadmium decreased the iron concentrations in the liver of voles, whereas zinc concentrations increased in both the kidney and liver...
  44. ncbi Presynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors modulate release of inhibitory amino acids in rat spinal cord dorsal horn
    H S Engelman
    Department of Physiology and Cellular Biophysics and the Center for Neurobiology and Behavior, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Neuroscience 139:539-53. 2006
    ....
  45. ncbi Metal binding of metallothioneins in human astrocytomas (U87 MG, IPDDC-2A)
    Magda Tusek Znidaric
    National Institute of Biology, Vecna pot 111, 1000, Ljubljana, Slovenia
    Biometals 20:781-92. 2007
    ..cell lines, U87 MG (astrocytoma-glioblastoma, grade IV) and IPDDC-2A (astrocytoma, grade II), on exposure to cadmium chloride (1 microM)...
  46. ncbi Clotrimazole, an antifungal drug possessing diverse actions, increases the vulnerability to cadmium in lymphocytes dissociated from rat thymus
    Tomohiro M Oyama
    Laboratory of Cell Signaling, Faculty of Integrated Arts and Sciences, The University of Tokushima, Tokushima 770-8502, Japan
    Toxicology 228:269-79. 2006
    ..It is also the case for PbCl(2), but not the case for HgCl(2). It is concluded that clotrimazole can modulate the cytotoxicity of some heavy metals...
  47. ncbi Characterization and in vitro cytotoxicity testing of ethanolamine-derived cadmium chelating agents
    Mikhail Zhukalin
    Departments of Chemistry, Albertson College of Idaho, Caldwell, Idaho 83605 4432, USA
    Biometals 20:61-72. 2007
    ..MTT assays showed that administration of 3 (cadmium complex of 1) resulted in cytotoxicity lower than that of cadmium chloride, but higher than that of the chelator 1 alone...
  48. ncbi Potential effect on cellular response to cadmium of a single-nucleotide A --> G polymorphism in the promoter of the human gene for metallothionein IIA
    Kayoko Kita
    Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Hum Genet 120:553-60. 2006
    ..These results suggest that the A --> G single-nucleotide polymorphism reduces the efficiency of those aspects of the transcription of the gene for MT-IIA that are controlled by general transcription factors...
  49. ncbi Excessive activation of cyclic nucleotide-gated channels contributes to neuronal degeneration of photoreceptors
    Géraldine Vallazza-Deschamps
    Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine, INSERM U 592, Universite Pierre et Marie Curie, Bâtiment Kourilsky 6ème étage, 75571 Paris Cedex 12, France
    Eur J Neurosci 22:1013-22. 2005
    ....
  50. ncbi Cytoprotective and antioxidant role of diallyl tetrasulfide on cadmium induced renal injury: an in vivo and in vitro study
    L Pari
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamilnadu, India
    Life Sci 80:650-8. 2007
    ..The present study suggests that the cytoprotective potential of DTS in Cd toxicity might be due to its antioxidant and metal chelating properties, which could be useful for achieving optimum effects in Cd induced renal damage...
  51. ncbi Anatomical and functional evidence for a role of arginine-vasopressin (AVP) in rat olfactory epithelium cells
    Grégoire Levasseur
    Unité de Neurobiologie de l Olfaction et de la Prise Alimentaire, Equipe Récepteurs et Communications Cellulaires, Institut National de la Recherche Agronomique, Domaine de Vilvert, 78352 Jouy en Josas Cedex
    Eur J Neurosci 20:658-70. 2004
    ..V1b-R were strongly associated with Bowman's gland cells and globose basal cells. These localizations suggested potential multifaceted roles of a hormone, AVP, in the olfactory epithelium...
  52. ncbi Comparative hepatic and renal toxicity of cadmium in male and female rats
    Udita Gubrelay
    Department of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior-474 002, India
    J Environ Biol 25:65-73. 2004
    Rats (male and female) were exposed to 0.5 mg/kg and 1 mg/kg cadmium as cadmium chloride for 3 days and subsequently sacrificed for cadmium concentration and other biochemical variables indicative of hepatic and renal damage...
  53. ncbi Comparative studies on the uptake and effects of cadmium and zinc on the cellular energy allocation of two freshwater gastropods
    L Moolman
    Department of Zoology, Kingsway Campus, University of Johannesburg, P O Box 524, Auckland Park 2006, South Africa
    Ecotoxicol Environ Saf 68:443-50. 2007
    ..A combined study on metal uptake and biomarker responses in organisms allows the ability to make interspecies sensitivity comparisons in ecotoxicological studies...
  54. ncbi Adrenomedullin fails to reduce cadmium-induced oxidative damage in rat liver
    Mukaddes Esrefoglu
    Department of Histology and Embryology, Medical Faculty, Inonu University, Malatya 44280, Turkey
    Exp Toxicol Pathol 58:367-74. 2007
    ..We conclude that although we administered a high dose of adrenomedullin, it failed to reduce cadmium-induced hepatic damage probably because of the irreversibility of Cd-induced hepatic injury...
  55. ncbi Heavy metal toxicity in Exosphaeroma gigas (Crustacea, Isopoda) from the coastal zone of Beagle Channel
    Erica Giarratano
    Centro Austral de Investigaciones Científicas CADIC CONICET, Av B Houssay 200, P O Box 92, V9410BFD Ushuaia, Tierra del Fuego, Argentina
    Ecotoxicol Environ Saf 68:451-62. 2007
    ..In general terms, O:N atomic ratios indicated a preponderant protein metabolism. Bioaccumulation of assayed metals was higher at lowest salinity and increased with increasing toxic concentrations...
  56. ncbi The nitric oxide prodrug, V-PYRRO/NO, protects against cadmium toxicity and apoptosis at the cellular level
    Wei Qu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Nitric Oxide 12:114-20. 2005
    ..Thus, the prodrug, V-PYRRO/NO, protects against the adverse effects of cadmium directly within rat liver cells apparently through generation of NO and, at least in part, by facilitation of cadmium-induced MT synthesis...
  57. ncbi Cadmium down-regulates human OGG1 through suppression of Sp1 activity
    Cha Kyung Youn
    Department of Pharmacology, School of Medicine, Chosun University, 375 Seosuk dong, Gwangju 501 759, Korea
    J Biol Chem 280:25185-95. 2005
    ....
  58. ncbi Cadmium inhibits delta-aminolevulinate dehydratase from rat lung in vitro: interaction with chelating and antioxidant agents
    Cristiane Luchese
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105 900, RS, Brazil
    Chem Biol Interact 165:127-37. 2007
    ..In contrast, these compounds potentiated the inhibition induced by Cd(2+) in rat lung...
  59. ncbi Divalent metal transport in the green microalga Chlamydomonas reinhardtii is mediated by a protein similar to prokaryotic Nramp homologues
    Alexandra Rosakis
    Environmental Microbiology and Molecular Ecotoxicology, Swiss Federal Institute for Environmental Science and Technology (EAWAG, Uberlandstrasse 133, CH-8600 Duebendorf, Switzerland
    Biometals 18:107-20. 2005
    ..reinhardtii DMT1 has a broad specificity, acting in the transport of several divalent metals (manganese, iron, cadmium, copper), but excluding zinc...
  60. ncbi Regulation of synaptic input to hypothalamic presympathetic neurons by GABA(B) receptors
    Q Chen
    Department of Anesthesiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Neuroscience 142:595-606. 2006
    ..This presynaptic action of GABA(B) receptors is mediated by the N-ethylmaleimide-sensitive G(i/o) proteins, but independent of voltage-gated Ca2+ and K+ channels...
  61. ncbi Pifithrin-alpha (PFT-alpha) caused differential protection of rat liver cells and HepG2 cell line in response to the selective cytotoxicity of arsenic and cadmium
    Rowshan A Begum
    Jackson State University, Department of Biology, Jackson, MS 39217, USA
    Biomed Sci Instrum 38:41-6. 2002
    ..In contrast, there was significant difference in the protection of rat liver cells upon exposure to arsenic. We conclude that Pifithrin-alpha exhibits protection to normal cells, which can play an important role in cancer chemotherapy...
  62. ncbi Expression of the mRNA of heme-binding protein 23 is coordinated with that of heme oxygenase-1 by heme and heavy metals in primary rat hepatocytes and hepatoma cells
    S Immenschuh
    Department of Pediatrics, Cornell University Medical College, New York, New York 10021, USA
    Biochemistry 34:13407-11. 1995
    ..The data suggest that the expression of HBP23 and HO-1 mRNA is regulated by (a) similar mechanism(s) in liver and that both genes could play a common physiological role as antioxidants and/or in heme metabolism...
  63. ncbi Protective effect of metallothionein against the toxicity of cadmium and other metals(1)
    J D Park
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160-7417, USA
    Toxicology 163:93-100. 2001
    ..These results suggest that MT is an important protein in the cellular defense against Cd toxicity and lethality, but it provides much less protection against the lethality of the other metals...
  64. ncbi Cu-metallothioneins (Cu(I)8-MTs) in LEC rat livers 13 weeks after birth still act as antioxidants
    N Shishido
    Department of Chemistry, Asahikawa Medical College, Japan
    Arch Biochem Biophys 387:216-22. 2001
    ..Cu2+-catalyzed oxidation of DNA was strongly inhibited both in the presence of Cu-unsaturated MTs and GSH. The results suggest that Cu(I)8-MTs from LEC rat livers just before hepatitis still act as antioxidants...
  65. ncbi Unique gene expression patterns in liver and kidney associated with exposure to chemical toxicants
    M J Bartosiewicz
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, USA
    J Pharmacol Exp Ther 297:895-905. 2001
    ....
  66. ncbi Effect of hemolytic and iron-deficiency anemia on intestinal absorption and tissue accumulation of cadmium
    Kyong Son Min
    Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Osaka, Japan
    Toxicol Lett 179:48-52. 2008
    ..This suggests that anemia may be a risk factor for Cd accumulation...
  67. ncbi Molecular cloning of the rat metallothionein 1 (MT-1) mRNA sequence
    R D Andersen
    DNA 2:15-22. 1983
    Starting with liver mRNA from cadmium chloride-treated rats, we constructed a cDNA library. A mouse metallothionein 1 (MT-1) cDNA restriction fragment (Durnam et al...
  68. ncbi Localization of metallothionein in the brain of rat and mouse
    N Nishimura
    Department of Hygiene, Aichi Medical University, Japan
    J Histochem Cytochem 40:309-15. 1992
    ..The present result suggest a possible link of MT with cell growth of choroid plexus epithelium and ependymal cells, as well as a detoxifying role of MT in the blood-brain barrier and the cerebrospinal fluid-brain barrier...
  69. ncbi Functional studies on alpha 1-adrenoceptor subtypes mediating inotropic effects in rat right ventricle
    M C Michel
    Department of Medicine, University of Essen, Germany
    Br J Pharmacol 111:539-46. 1994
    ..Therefore, we speculate that alpha 1B-adrenoceptors exert a tonic inhibitory effect on alpha 1A-adrenoceptors...
  70. ncbi Radioligand binding studies of alpha 1-adrenoceptor subtypes in rat heart
    M C Michel
    Department of Medicine, University of Essen, Germany
    Br J Pharmacol 111:533-8. 1994
    ..Treatment withchloroethylclonidine reduces alpha 1B-adrenoceptor number by 96% but has only minor effects on alpha 1A-adrenoceptor density. Treatment with CdCl2 does not affect the number of either alpha 1-adrenoceptor subtype...
  71. ncbi Exposure of human proximal tubule cells to cytotoxic levels of CdCl2 induces the additional expression of metallothionein 1A mRNA
    J E Bylander
    Robert C Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown 26506, USA
    Toxicol Lett 76:209-17. 1995
    ..The finding of different profiles of mRNA expression provides evidence that the MT isoforms may have unique functions and that mRNA for the MT-1A gene could be a potential marker for heavy metal exposure and/or toxicity...
  72. ncbi Chemical modulation of metallothionein I and III mRNA in mouse brain
    H Zheng
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417, USA
    Neurochem Int 27:43-58. 1995
    ..mice and mice given chemicals known to increase MT-I, namely, lipopolysaccharide (LPS), zinc chloride (Zn), cadmium chloride (Cd), dexamethasone (Dex), ethanol, and kainic acid (KA)...
  73. ncbi Differential hepatotoxicity induced by cadmium in Fischer 344 and Sprague-Dawley rats
    Robert K Kuester
    Department of Pharmacology and Toxicology, Center for Toxicology, The University of Arizona, P.O. Box 210207, Tucson, Arizona 85721-0207, USA
    Toxicol Sci 65:151-9. 2002
    ..These protective factors may limit CdCl2-induced hepatocellular injury in SD compared with F344 rats by reducing KC activation and the subsequent inflammatory response that allows for the progression of hepatic injury...
  74. ncbi A comparison of 60, 70, and 90 kDa stress protein expression in normal rat NRK-52 and human HK-2 kidney cell lines following in vitro exposure to arsenite and cadmium alone or in combination
    Emily F Madden
    Program in Toxicology, University of Maryland, Baltimore, MD 21227, USA
    J Biochem Mol Toxicol 16:24-32. 2002
    ..These data indicate a dose- and combination-related correlation between depression of the stress protein response and the onset of overt cellular toxicity and/or cell death. The threshold for these changes was cell line specific...
  75. ncbi Oral administration of diphenyl diselenide protects against cadmium-induced liver damage in rats
    Lysandro Pinto Borges
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria CEP 97105 900, RS, Brazil
    Chem Biol Interact 171:15-25. 2008
    ..In the present study, the effect of diphenyl diselenide, (PhSe)(2), on sub-chronic exposure with cadmium chloride (CdCl(2)) was investigated in rats...
  76. ncbi Comparison of transfer and effects of Cd on rats exposed in a short experimental snail-rat food chain or to CdCl2 dosed food
    F Hispard
    University of Franche Comte, Department of Environmental Biology, EA 3184 aff INRA, Place Leclerc, 25030 Besancon Cedex, France
    Environ Int 34:381-9. 2008
    ..This quantification of the trophic transfer of both inorganic and organic forms of a toxicant is a basis for a better assessment of the fate and effects of chemicals in food webs...
  77. ncbi Relationship between toxicity and cadmium accumulation in rats given low amounts of cadmium chloride or cadmium-polluted rice for 22 months
    M Shibutani
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    J Toxicol Sci 26:337-58. 2001
    ..Possible protective mechanisms may be operating...
  78. ncbi The hepatoprotective effects of selenium against cadmium toxicity in rats
    A A Newairy
    Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, Egypt
    Toxicology 242:23-30. 2007
    ..p.) daily for 10 days. The second group (cadmium chloride-treated group) received 2 mg/kg body weight cadmium chloride solution i.p. for a period of 10 days...
  79. ncbi Cytotoxic effects of some animal and vegetable extracts and some chemicals on liver and colon carcinoma and myosarcoma
    Vahdettin Bayazit
    Department of Biology, Faculty of Science and Arts, University of Dumlupinar, Kutahya, Turkey
    Saudi Med J 25:156-63. 2004
    To study, the cytotoxic effects of some biological and chemical agents on G1, S, G2, M and G0 phases of liver and colon carcinomas and myosarcoma cells obtained with chemical carcinogens dimethylbenzanthracene (DMBA) and cadmium chloride.
  80. ncbi Purification and characterization of heme oxygenase from chick liver. Comparison of the avian and mammalian enzymes
    H L Bonkovsky
    Department of Medicine, Winship Cancer Center, Emory University, Atlanta, GA 30322
    Eur J Biochem 189:155-66. 1990
    ..14.99.3) was purified from liver microsomes of chicks pretreated with cadmium chloride. The purification involved solubilization of microsomes with Emulgen 913 and sodium cholate, followed by DEAE-..
  81. ncbi Ascorbic acid, garlic extract and taurine alleviate cadmium-induced oxidative stress in freshwater catfish (Clarias batrachus)
    Puneet Kumar
    Aquatic Biotechnology and Fish Pathology Laboratory, Department of Animal Science, M J P Rohilkhand University, Bareilly 243 006, India
    Sci Total Environ 407:5024-30. 2009
    ..The fishes of groups II, III, IV and V were challenged with 5 ppm of cadmium chloride monohydrate (CdCl2.H2O), whereas groups VI, VII, VIII and IX were exposed to 10 ppm CdCl2...
  82. ncbi In vitro platinum drug chemosensitivity of human cervical squamous cell carcinoma cell lines with intrinsic and acquired resistance to cisplatin
    K J Mellish
    Drug Development Section, Institute of Cancer Research, Sutton, Surrey, UK
    Br J Cancer 68:240-50. 1993
    ..05) was observed between platinum drug chemosensitivity and either glutathione levels or cadmium chloride sensitivity, an indicator of metallothionein levels...
  83. ncbi Effects of cadmium on hepatocellular DNA damage, proto-oncogene expression and apoptosis in rats
    Ri An Yu
    Department of Occupational and Environmental Health, Shool of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, Guangdong, China
    Biomed Environ Sci 20:146-53. 2007
    ..To study the effects of cadmium on hepatocellular DNA damage, expression of proto-oncogenes c-myc, c-fos, and c-jun as well as apoptosis in rats...
  84. ncbi Population growth of Brachionus macracanthus (Rotifera) in relation to cadmium toxicity: influence of algal (Chlorella vulgaris) density
    S Nandini
    UIICSE, Division of Research and Postgraduate Studies, National Autonomous University of Mexico, Campus Iztacala, Los Reyes, Tlalnepantla, State of Mexico, Mexico
    J Environ Sci Health A Tox Hazard Subst Environ Eng 42:1467-72. 2007
    ..Chronic toxicity tests were conducted under 4 different concentrations (0.000625-0.005 mg L(- 1)) of cadmium chloride at 23 degrees C under 3 food (Chlorella vulgaris) levels (0.5 x 10(6), 1.0 x 10(6) and 2...
  85. ncbi Cadmium-induced changes in lipid peroxidation, blood hematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and beta-carotene
    Fatma M El-Demerdash
    Department of Environmental Studies, Institute of Graduate Studies and Research, University of Alexandria, 163, Horreya Avenue, P O Box 832, Alexandria 21526, Egypt
    Food Chem Toxicol 42:1563-71. 2004
    ..b>Cadmium chloride (CdCl2, 5 mg/kg BW, 1/15 LD50), vitamin E (100 mg/kg BW), beta-carotene (10 mg/kg BW), and vitamin E with ..
  86. ncbi Hepatic and renal metallothionein induction by an oral equimolar dose of zinc, cadmium or mercury in mice
    S K Tandon
    Chemical Toxicology, Industrial Toxicology Research Centre, P0 Box 80, 226001, Lucknow, India
    Food Chem Toxicol 39:571-7. 2001
    ..liver and kidney more in their supernatant cytosol fraction (SCF) than in their NMF at 24 h after a dose of cadmium chloride. The cadmium levels showed a decreasing trend in hepatic fractions and an increasing trend in renal fractions ..
  87. ncbi Cadmium increases human fetal germ cell apoptosis
    Gaëlle Angenard
    Laboratory of Differentiation and Radiobiology of the Gonads, CEADSV iRCM SCSR, Fontenay aux Roses, France
    Environ Health Perspect 118:331-7. 2010
    ..Adverse effects of this heavy metal on reproductive function have been identified in adults; however, no studies have examined its effects on human reproductive organs during development...
  88. ncbi Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential
    A P Li
    In Vitro Technologies Inc, University of Maryland Technology C, Baltimore, 21044, USA
    Chem Biol Interact 121:17-35. 1999
    ..using MTT metabolism as an endpoint, was observed for the known hepatotoxic chemicals tamoxifen, clozapine, cadmium chloride, diclofenac, amiodarone, tranylcypromine, precocene II, but not for 2-thiouracil...
  89. ncbi Induction of a heat shock response (HSP 72) in rat embryos exposed to selected chemical teratogens
    P E Mirkes
    Department of Pediatrics, University of Washington School of Medicine, Seattle 98195
    Teratology 49:135-42. 1994
    ..The chemical teratogens studied include N-Acetoxy-2-acetylaminofluorene (N-Ac-AAF), cadmium chloride (CAD), cyclophosphamide (CP), sodium arsenite (AS), and sodium salicylate (SAL)...
  90. ncbi Mechanisms underlying spontaneous rhythmical contractions in irideal arterioles of the rat
    C E Hill
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, GPO Box 334, Canberra, ACT 2601, Australia
    J Physiol 521:507-16. 1999
    ..6. Spontaneous activity was not affected by felodipine (1 nM) or nifedipine (1 microM), but was abolished by cadmium chloride (1 microM) or superfusion with calcium-free solution. 7...
  91. ncbi Induction of heme oxygenase in the small intestinal epithelium: a response to oral cadmium exposure
    D W Rosenberg
    Rockefeller University, New York, NY 10021
    Toxicology 67:199-210. 1991
    ..b>Cadmium chloride was administered via drinking water (0, 5 or 50 ppm cadmium) for 5 or 30 days, and heme oxygenase, 7-..
  92. ncbi Unique organoprotective properties of a novel IH636 grape seed proanthocyanidin extract on cadmium chloride-induced nephrotoxicity, dimethylnitrosamine (DMN)-induced splenotoxicity and mocap-induced neurotoxicity in mice
    S D Ray
    Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA
    Res Commun Mol Pathol Pharmacol 107:105-28. 2000
    ..assess the bioavailability of GSPE in multiple target organs, (ii) quantify GSPE's capacity to avert cadmium chloride (CdCl2)-induced nephrotoxicity, dimethylnitrosamine (DMN)-induced splenotoxicity and O-ethyl-S,S-dipropyl ..
  93. ncbi The present lack of evidence for unique rodent germ-cell mutagens
    I D Adler
    GSF Institut für Säugetiergenetik, Neuherberg, F R G
    Mutat Res 212:55-66. 1989
    Six chemicals, diethylhexyl phthalate (DEHP), ethanol, cyclohexylamine (CHA), sodium saccharin (NaS), cadmium chloride (CdCl2) and triflupromazine (TFP), were suggested to be unique germ-cell mutagens (Auletta and Ashby, 1988) by the ..
  94. ncbi Oncogenic potential of mouse translation elongation factor-1 delta, a novel cadmium-responsive proto-oncogene
    Pius Joseph
    Molecular Epidemiology Laboratory, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Biol Chem 277:6131-6. 2002
    ..cell transformation and tumorigenesis were investigated using Balb/c-3T3 cells transformed with cadmium chloride. Differential display analysis of gene expression revealed consistent and reproducible overexpression of a ..
  95. ncbi Short-term dynamic culture of rat testicular fragments as a model to assess effects on steroidogenesis--potential use and limitations
    Alexius Freyberger
    Bayer Schering Pharma AG, BSP GDD GED GTOX Special Toxicology, Wuppertal, Germany
    Reprod Toxicol 30:36-43. 2010
    ..danazol, flutamide, diethylstilbestrol, genistein, butylparaben, nonoxynol-9, dimethoate, RU 486, and cadmium chloride) were used to explore the performance of the assay...
  96. ncbi Effects of genetic mutations and chemical exposures on Caenorhabditis elegans feeding: evaluation of a novel, high-throughput screening assay
    Windy A Boyd
    Laboratory of Molecular Toxicology, National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 2:e1259. 2007
    ..elegans pharynx is a favorable model for studying neuromuscular function, and the effects of chemicals on neuromuscular activity, i.e., feeding. Current feeding methodologies, however, are labor intensive and only semi-quantitative...
  97. ncbi Pollution-affected fish hepatic transcriptome and its expression patterns on exposure to cadmium
    M Auslander
    Israel Oceanographic and Limnological Research, Haifa 31080, Israel
    Mar Biotechnol (NY) 10:250-61. 2008
    ..acid, tributyl-tin chloride, lindane, estradiol, 4-nonylphenol, methyl mercury chloride, and cadmium chloride. Five mixtures of the pollutants were injected. Each mixture included one to three compounds...
  98. ncbi Alteration by cadmium of rat submandibular gland secretory function and the role of the l-arginine/nitric oxide pathway
    M Abdollahi
    Faculty of Pharmacy, Department of Toxicology and Pharmacology, Tehran University of Medical Sciences, 14155 6451, Tehran, Iran
    Pharmacol Res 42:591-7. 2000
    ..Fourteen days treatment with 10 mg l(-1)cadmium as cadmium chloride in drinking water caused significant alterations on salivary function...
  99. ncbi Lead induces the expression of endoplasmic reticulum chaperones GRP78 and GRP94 in vascular endothelial cells via the JNK-AP-1 pathway
    Yasuhiro Shinkai
    Organization for Frontier Research in Preventive Pharmaceutical Sciences, Hokuriku University, Kanazawa, Ishikawa 920 1181, Japan
    Toxicol Sci 114:378-86. 2010
    ..Compared with other metal(loid)s, including cadmium chloride, zinc sulfate, copper sulfate, and sodium arsenite, lead nitrate was found to be the most potent metal to ..
  100. ncbi Modulation of adrenal cell functions by cadmium salts. 1. Cadmium chloride effects on basal and ACTH-stimulated steroidogenesis
    O P Mgbonyebi
    Department of Physiology, Meharry Medical College, Nashville, Tennessee 37208 3559
    Cell Biol Toxicol 9:223-34. 1993
    ..20-DHP), were used to investigate the acute nonlethal effects of incremental cadmium chloride (CdCl2) concentrations on basal and maximally stimulated steroid secretion...
  101. ncbi Simultaneous coexposure to inorganic mercury and cadmium: a study of the renal and hepatic disposition of mercury and cadmium
    Rudolfs K Zalups
    Division of Basic Medical Sciences, Mercer University School of Medicine, Macon, Georgia 31207, USA
    J Toxicol Environ Health A 65:1471-90. 2002
    ..Coadministration of a 0.5- micromol/kg dose of mercuric chloride with a 10- micromol/kg dose of cadmium chloride resulted in a decrease in the net renal accumulation of inorganic mercury at 1 and 24 h after exposure...

Research Grants86

  1. OXIDANT HEPATIC INJURY IN CHOLESTASIS
    Ronald Sokol; Fiscal Year: 2000
    ..Metallothionein will then be induced in rats by zinc chloride or cadmium chloride injections, and the effect of increased hepatic metallothionein levels on in vitro bile acid toxicity to ..
  2. OXIDANT HEPATIC INJURY IN CHOLESTASIS
    Ronald Sokol; Fiscal Year: 1993
    ..Metallothionein will then be induced in rats by zinc chloride or cadmium chloride injections, and the effect of increased hepatic metallothionein levels on in vitro bile acid toxicity to ..
  3. TRANSPORT MECHANISMS IN CORNEAL ENDOTHELIUM
    Jorge Fischbarg; Fiscal Year: 2004
    ..markers, and determinations of the coupling ratio after junctional modification by agents including cadmium chloride, protamine, and polylysine...
  4. HEAVY METALS AND POLYDRUG SELF-ADMINISTRATION
    Jack Nation; Fiscal Year: 2005
    ....
  5. Heavy Metal and Drug Self-Administration: Mechanisms
    Paul Wellman; Fiscal Year: 2007
    ..e., lead contamination and cocaine use. Based on the available literature, there is reason to believe that environmental pollutants may increase vulnerability to drug addiction. ..
  6. TRANSPORT AND TOXICITY OF MERCURY IN THE NEPHRON
    RUDOLFS ZALUPS; Fiscal Year: 2006
    ..to date, of the mechanisms involved in the uptake of inorganic mercuric ions along pars recta segments of the proximal tubule, which are the segments of the nephron most vulnerable to the nephrotoxic effects of mercury ..
  7. SYNAPTIC VESICLE TRAFFICKING IN HIPPOCAMPAL SYNAPSES
    Venkatesh N Murthy; Fiscal Year: 2010
    ..These experiments will elucidate fundamental presynaptic mechanisms of vesicle traffic in GABAergic synapses and how they are altered by activity. ..
  8. Metallothionein, Environment Insult and Bladder Cancer
    Donald Sens; Fiscal Year: 2005
    ..The completion of these studies would provide a strong link between a protein family known to mediate the cell's response to environmental exposure and a cancer strongly associated with exposure to environmental agents. ..
  9. Metallothionein Isoform 3 as a Urinary Marker for Bladder Cancer
    Donald Sens; Fiscal Year: 2007
    ....
  10. The Causes and Consequences of Complementation and Selfishness in Viruses
    Sarah Joseph; Fiscal Year: 2007
    ..As a result, understanding these interactions in bacteriophage may provide insights into the evolution and pathogenesis of viral pathogens of humans. ..
  11. Comprehensive Assessment of Bladder Cancer Genetic Susceptibility
    Angeline Andrew; Fiscal Year: 2007
    ..We will also investigate the genetic basis for the inter-individual variation in risk following carcinogenic exposures including smoking. ..
  12. North Dakota INBRE: Health and the Environment
    Donald A Sens; Fiscal Year: 2010
    ....
  13. SYNAPTIC VESICLE TRAFFICKING IN HIPPOCAMPAL SYNAPSES
    Venkatesh Murthy; Fiscal Year: 2007
    ..Since synaptic transmission is adversely affected in many disorders of the nervous system, a better understanding of synaptic release mechanisms will provide a rational basis for treatment. ..
  14. METALLOTHIONEIN ISOFORM 3 AND RENAL CADMIUM TOXICITY
    Donald Sens; Fiscal Year: 2005
    ..The long term goal of the proposed research is to define the functional and regulatory role of MT-3 expression in the proximal tubule under conditions of normal homeostasis and when exposed to cadmium. ..
  15. MECHANISMS OF CADMIUM TOXICITY IN EPITHELIAL CELLS
    WALTER PROZIALECK; Fiscal Year: 2007
    ..Furthermore, the results of these studies could have more general implications regarding the mechanisms by which toxic substances affect living organisms. ..
  16. Mid-Brain Modulation of Social Attachment
    Joseph Curtis; Fiscal Year: 2007
    ..The results of these studies will further our understanding of the brain circuitry involved in social attachment, and thus provide insights into the causes of a variety of human ailments. ..
  17. MECHANISMS OF CADMIUM TOXICITY IN EPITHELIAL CELLS
    WALTER PROZIALECK; Fiscal Year: 2001
    ..Furthermore, the results of these studies could have more general implications concerning the mechanisms by which toxic substances damage living cells. ..
  18. North Dakota INBRE: Health and the Environment
    Donald Sens; Fiscal Year: 2009
    ..abstract_text> ..
  19. Metallothionein Isoform 3 as a Urinary Marker for Bladder Cancer
    Donald Sens; Fiscal Year: 2009
    ....
  20. North Dakota INBRE: Health and the Environment
    Donald Sens; Fiscal Year: 2007
    ..An Outreach Core is designed to empower tribal colleges to strengthen their introductory science curricula so as to increase the level of preparation of tribal college students for transitioning to four-year science programs. ..