coumestrol

Summary

Summary: A daidzein derivative occurring naturally in forage crops which has some estrogenic activity.

Top Publications

  1. ncbi Neurobehavioral actions of coumestrol and related isoflavonoids in rodents
    Patricia L Whitten
    Center for Behavioral Neuroscience, Emory University, Atlanta, GA 30329, USA
    Neurotoxicol Teratol 24:47-54. 2002
  2. ncbi The effects of the phytoestrogen, coumestrol, on gonadotropin-releasing hormone (GnRH) mRNA expression in GT1-7 GnRH neurones
    J Bowe
    Centre for Reproduction, Endocrinology and Diabetes, King s College London, UK
    J Neuroendocrinol 15:105-8. 2003
  3. ncbi Profiles of phytoestrogens in human urine from several Asian countries
    Tatsuya Kunisue
    Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Empire State Plaza, P O Box 509, Albany, New York 12201 0509, USA
    J Agric Food Chem 58:9838-46. 2010
  4. ncbi The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor
    Hongwei Wang
    Albert Einstein College of Medicine, Albert Einstein Cancer Center, Bronx, New York 10461, USA
    Mol Endocrinol 22:838-57. 2008
  5. ncbi Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta
    G G Kuiper
    Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Endocrinology 139:4252-63. 1998
  6. pmc Effect of soybean coumestrol on Bradyrhizobium japonicum nodulation ability, biofilm formation, and transcriptional profile
    Hae In Lee
    Department of Biology, University of Texas, Arlington, Texas, USA
    Appl Environ Microbiol 78:2896-903. 2012
  7. pmc Coumestrol from the national cancer Institute's natural product library is a novel inhibitor of protein kinase CK2
    Shu Liu
    Thoracic Oncology Laboratory, Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    BMC Pharmacol Toxicol 14:36. 2013
  8. ncbi Analysis of the promoter-specific estrogenic potency of the phytoestrogens genistein, daidzein and coumestrol
    Oliver Zierau
    Institute for Zoology, Technische Universitat Dresden, Zellescher Weg 20, 02127 Dresden, Germany
    Planta Med 72:184-6. 2006
  9. ncbi Studies on coumestrol/beta-cyclodextrin association: Inclusion complex characterization
    Camila Franco
    Programa de Pós Graduação em Ciências Farmacêuticas, Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul Av Ipiranga, 2752, Porto Alegre 90 610 000, RS, Brazil
    Int J Pharm 369:5-11. 2009
  10. ncbi The binding of lignans, flavonoids and coumestrol to CYP450 aromatase: a molecular modelling study
    Sampo Karkola
    Laboratory of Organic Chemistry, Department of Chemistry, Faculty of Science, University of Helsinki, P O Box 55, FIN 00014 Helsinki, Finland
    Mol Cell Endocrinol 301:235-44. 2009

Detail Information

Publications175 found, 100 shown here

  1. ncbi Neurobehavioral actions of coumestrol and related isoflavonoids in rodents
    Patricia L Whitten
    Center for Behavioral Neuroscience, Emory University, Atlanta, GA 30329, USA
    Neurotoxicol Teratol 24:47-54. 2002
    ..This paper reviews the responses of rodents to diets containing coumestrol or an isoflavone supplement in comparison to animals fed the phytoestrogen-free AIN76A diet...
  2. ncbi The effects of the phytoestrogen, coumestrol, on gonadotropin-releasing hormone (GnRH) mRNA expression in GT1-7 GnRH neurones
    J Bowe
    Centre for Reproduction, Endocrinology and Diabetes, King s College London, UK
    J Neuroendocrinol 15:105-8. 2003
    ..We examined the effect of coumestrol, alone and combined with ER antagonists, on gonadotropin-releasing hormone (GnRH) mRNA expression in GT1-7 cells...
  3. ncbi Profiles of phytoestrogens in human urine from several Asian countries
    Tatsuya Kunisue
    Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Empire State Plaza, P O Box 509, Albany, New York 12201 0509, USA
    J Agric Food Chem 58:9838-46. 2010
    ..namely, enterolactone, enterodiol, daidzein, equol, O-desmethylangolensin (O-DMA), genistein, and coumestrol, in 199 human urine samples from three Asian countries, Vietnam (Hanoi and Ho Chi Minh), Cambodia (Phnom Penh), ..
  4. ncbi The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor
    Hongwei Wang
    Albert Einstein College of Medicine, Albert Einstein Cancer Center, Bronx, New York 10461, USA
    Mol Endocrinol 22:838-57. 2008
    ..We provide evidence that a naturally occurring phytoestrogen, coumestrol, is an antagonist of the nuclear receptor PXR (NR1I2)...
  5. ncbi Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta
    G G Kuiper
    Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Endocrinology 139:4252-63. 1998
    ..Some phytoestrogens such as coumestrol, genistein, apigenin, naringenin, and kaempferol compete stronger with E2 for binding to ER beta than to ER ..
  6. pmc Effect of soybean coumestrol on Bradyrhizobium japonicum nodulation ability, biofilm formation, and transcriptional profile
    Hae In Lee
    Department of Biology, University of Texas, Arlington, Texas, USA
    Appl Environ Microbiol 78:2896-903. 2012
    ..Among 10 polyphenolic compounds isolated from soybean roots in our previous study, coumestrol showed the highest antioxidant activity. In this study, its effect on the soybean nodulation was tested...
  7. pmc Coumestrol from the national cancer Institute's natural product library is a novel inhibitor of protein kinase CK2
    Shu Liu
    Thoracic Oncology Laboratory, Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    BMC Pharmacol Toxicol 14:36. 2013
    ..To identity novel classes of inhibitors for CK2, we screened a natural product library obtained from National Cancer Institute...
  8. ncbi Analysis of the promoter-specific estrogenic potency of the phytoestrogens genistein, daidzein and coumestrol
    Oliver Zierau
    Institute for Zoology, Technische Universitat Dresden, Zellescher Weg 20, 02127 Dresden, Germany
    Planta Med 72:184-6. 2006
    ..In this study we have analyzed the effects of the phytoestrogens daidzein, coumestrol and genistein in promoter-specific reporter gene systems...
  9. ncbi Studies on coumestrol/beta-cyclodextrin association: Inclusion complex characterization
    Camila Franco
    Programa de Pós Graduação em Ciências Farmacêuticas, Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul Av Ipiranga, 2752, Porto Alegre 90 610 000, RS, Brazil
    Int J Pharm 369:5-11. 2009
    b>Coumestrol is an estrogenic and antioxidant agent, characterized by its low solubility in aqueous and lipophilic media, once in the aglicone form...
  10. ncbi The binding of lignans, flavonoids and coumestrol to CYP450 aromatase: a molecular modelling study
    Sampo Karkola
    Laboratory of Organic Chemistry, Department of Chemistry, Faculty of Science, University of Helsinki, P O Box 55, FIN 00014 Helsinki, Finland
    Mol Cell Endocrinol 301:235-44. 2009
    ..Sets of phytoestrogens, such as lignans, flavonoids/isoflavonoids and coumestrol, were docked into the aromatase active site and the binding modes were studied.
  11. pmc Estrogenic activity of coumestrol, DDT, and TCDD in human cervical cancer cells
    Kenneth Ndebele
    The Laboratory of Cancer Immunology, Target Identification and Validation, College of Science, Engineering and Technology, Jackson State University, Jackson, MS 39217, USA
    Int J Environ Res Public Health 7:2045-56. 2010
    ..Using human cervical cancer cells (HeLa cells) as a model, the effects of representative xenoestrogens (Coumestrol-a phytoestrogen, tetrachlorodioxin (TCDD)-a herbicide and DDT-a pesticide) on proliferation, cell cycle, and ..
  12. ncbi Coumestrol induces senescence through protein kinase CKII inhibition-mediated reactive oxygen species production in human breast cancer and colon cancer cells
    Young Hoon Lee
    School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu 702 701, Republic of Korea
    Food Chem 141:381-8. 2013
    ..Merrill and was identified as coumestrol by structural analysis...
  13. ncbi Induction of the soybean phytoalexins coumestrol and glyceollin by Aspergillus
    S M Boue
    Southern Regional Research Center, Agricultural Research Center, U S Department of Agriculture, New Orleans, LA 70179 0687, USA
    J Agric Food Chem 48:2167-72. 2000
    ..A maximum concentration of coumestrol of 27.2 microg/g fw was obtained from soybean cotyledons inoculated with A. niger...
  14. pmc Dietary phytoestrogen intakes and cognitive function during the menopausal transition: results from the Study of Women's Health Across the Nation Phytoestrogen Study
    Gail A Greendale
    Division of Geriatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1687, USA
    Menopause 19:894-903. 2012
    ..Previous research suggests that higher dietary or supplemental intakes of isoflavones and lignans are related to better cognitive performance in middle-aged and older women...
  15. ncbi Coumestrol decreases intestinal alkaline phosphatase activity in post-delivery mice but does not affect vitamin D receptor and calcium channels in post-delivery and neonatal mice
    Yuka Kirihata
    Laboratory of Animal Physiology and Functional Anatomy, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    J Reprod Dev 54:35-41. 2008
    In this study, we investigated the effects of administration of coumestrol during pregnancy on calcium (Ca) metabolism in post-delivery maternal and neonatal mice. From 6.5 to 16...
  16. ncbi Pilot study of a specific dietary supplement in tumor-bearing mice and in stage IIIB and IV non-small cell lung cancer patients
    A S Sun
    Connecticut Institute for Aging and Cancer, Milford, CT 06460, USA
    Nutr Cancer 39:85-95. 2001
    ..4 mg of daidzein, 2.6 mg of genistein, and 16 mg of coumestrol. Mouse food containing 5% SV (wt/wt) was associated with a 53-74% inhibition of tumor growth rate...
  17. ncbi Effects of the environmental estrogens bisphenol A, o,p'-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7
    Patrick Diel
    Institut für Morphologie und Tumorforschung, Deutsche Sporthochschule Koln, Carl Diem Weg 6, 50927, Koln, Germany
    J Steroid Biochem Mol Biol 80:61-70. 2002
    ..analysed effects of the environmental estrogens bisphenol A (BPA), p-tert-octylphenol (OCT), o,p'-DDT (DDT) and coumestrol (COU) on cell proliferation, apoptosis induction, progesterone receptor (PR) and androgen receptor (AR) mRNA ..
  18. ncbi Molecular basis for the interaction of four different classes of substrates and inhibitors with human aromatase
    Yanyan Hong
    Department of Surgical Research and Division of Information Sciences, Beckman Research Institute of the City of Hope, 1500 E Duarte Road, Duarte, CA 91010, United States
    Biochem Pharmacol 75:1161-9. 2008
    ..17-methyltestosterone (a synthetic androgen), dibenzylfluorescein (a synthetic substrate of aromatase), and coumestrol (a phytoestrogen), with aromatase were investigated through spectral analysis using purified human recombinant ..
  19. ncbi Daidzein, coumestrol and zearalenone affect lipogenesis and lipolysis in rat adipocytes
    K Szkudelska
    Department of Animal Physiology and Biochemistry, University of Agriculture, Wołyńska Poznan, Poland
    Phytomedicine 9:338-45. 2002
    Daidzein, coumestrol and zearalenone - compounds called phytoestrogens, considered as active biological factors affecting many important physiological and biochemical processes appeared to be also significant regulators of adipocyte ..
  20. ncbi Suppressive effect of neonatal treatment with a phytoestrogen, coumestrol, on lordosis and estrous cycle in female rats
    Tom Kouki
    Laboratory of Neuroendocrinology, Faculty of Human Sciences, Waseda University, 2 579 15, Mikajima, Tokorozawa, Saitama 359 1192, Japan
    Brain Res Bull 64:449-54. 2005
    ..In the present study, the effects of a single neonatal injection with the phytoestrogen, coumestrol, on female reproductive functions were investigated...
  21. ncbi Inhibition of 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) activity of human lung microsomes by genistein, daidzein, coumestrol and C(18)-, C(19)- and C(21)-hydroxysteroids and ketosteroids
    Charles H Blomquist
    Department of Obstetrics and Gynecology, HealthPartners Regions Hospital, St Paul, MN 55101, USA
    Steroids 70:507-14. 2005
    ..dehydrogenase (17beta-HSD) are inhibited by the isoflavones, genistein and daidzein, and by coumestrol. In general, the extent of inhibition has been expressed in terms of IC50-values, which do not give information ..
  22. ncbi Estimated intakes of isoflavones and coumestrol in Korean population
    Jeonghee Surh
    Department of Food and Nutrition, College of Human Ecology, Gwanak Gu, Seoul, Korea
    Int J Food Sci Nutr 57:325-44. 2006
    The dietary intakes and sources of isoflavones and coumestrol were estimated for each age group of Koreans based on data from the Korean Nutrition Survey conducted in 1998...
  23. ncbi Phytoestrogenic compounds in alfalfa sprout (Medicago sativa) beyond coumestrol
    Yong Han Hong
    Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan
    J Agric Food Chem 59:131-7. 2011
    b>Coumestrol has long been known as the phytoestrogenic compound in alfalfa...
  24. ncbi Inhibitory effect of natural and environmental estrogens on thymic hormone production in thymus epithelial cell culture
    K Sakabe
    Department of Morphology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Int J Immunopharmacol 21:861-8. 1999
    ..of 17beta-estradiol (natural estrogen) over 3 x 10(-11) M, genistein (phytoestrogen) over 3 x 10(-9) M, coumestrol (phytoestrogen) over 3 x 10(-9) M, alpha-zearalanol (livestock anabolic) over 3 x 10(-7) and bisphenol-A (..
  25. ncbi Phytoestrogen content of beverages, nuts, seeds, and oils
    Gunter G C Kuhnle
    MRC Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, United Kingdom
    J Agric Food Chem 56:7311-5. 2008
    ..The results published here will contribute to databases of dietary phytoestrogen content and allow a more accurate determination of phytoestrogen exposure in free-living individuals...
  26. pmc Phytoestrogen consumption and endometrial cancer risk: a population-based case-control study in New Jersey
    Elisa V Bandera
    The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Cancer Causes Control 20:1117-27. 2009
    ..02). We found a limited evidence of an association with any of the lignans evaluated, total lignans, coumestrol, individual isoflavones, total isoflavones, or total phytoestrogens...
  27. ncbi Effects of the phytoestrogen coumestrol on locomotor and fear-related behaviors in female mice
    J Garey
    Laboratory of Neurobiology and Behavior, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Horm Behav 40:65-76. 2001
    Effects of the estrogenic plant isoflavonoid coumestrol (COUM) on locomotor activity and fear-related behaviors in both the absence and the presence of estradiol benzoate (EB) were examined in adult ovariectomized Swiss-Webster mice...
  28. ncbi Gonadotrophin levels and morphological testicular features in rats after different doses of the phytoestrogen coumestrol
    C Rosario Tarragó-Castellanos
    Department of Biology of Reproduction, Universidad Autonoma Metropolitana Iztapalapa, CP 09340, Mexico City, Mexico
    Neuro Endocrinol Lett 27:487-92. 2006
    ..Their name makes reference to their ability to induce estrogenic responses in mammals. Coumestrol is a phytoestrogen that can be found in high concentrations in the dietary elements of cattle...
  29. ncbi Evaluation of the genotoxicity of the phytoestrogen, coumestrol, in AHH-1 TK(+/-) human lymphoblastoid cells
    O E Domon
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research (NCTR, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Mutat Res 474:129-37. 2001
    b>Coumestrol, a phytoestrogen found in high levels in alfalfa and red clover, is of concern since endocrine disorders have been observed in farm animals exposed to high levels of phytoestrogens...
  30. ncbi Coumestrol as well as isoflavones in soybean extract prevent bone resorption in ovariectomized rats
    She fang Ye
    Department of Biochemistry, Dokkyo University School of Medicine, Mibu, 321 0293 Tochigi, Japan
    Endocr Regul 37:145-52. 2003
    ..The objective of the present study was to determine whether there are any phytoestrogens other than isoflavones in soybeans that can act as antiosteoporotic agents...
  31. ncbi Dietary phytoestrogens are not associated with risk of overall breast cancer but diets rich in coumestrol are inversely associated with risk of estrogen receptor and progesterone receptor negative breast tumors in Swedish women
    Maria Hedelin
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Nutr 138:938-45. 2008
    ..We evaluated the associations between dietary phytoestrogen (isoflavonoids, lignans, and coumestrol) intake and risk of breast cancer and whether the ER/PR statuses of the tumor influence this relationship...
  32. ncbi Coumestrol antagonizes neuroendocrine actions of estrogen via the estrogen receptor alpha
    D A Jacob
    Department of Biology and Neuroscience Program, University of Virginia, Charlottesville 22904-4328, USA
    Exp Biol Med (Maywood) 226:301-6. 2001
    The phytoestrogen coumestrol has estrogenic actions on peripheral reproductive tissues. Yet in the brain this compound has both estrogenic and anti-estrogenic effects...
  33. ncbi Identification of phytoestrogens in bovine milk using liquid chromatography/electrospray tandem mass spectrometry
    Jean Philippe Antignac
    Laboratoire d Etude des Résidus et Contaminants dans les Aliments LABERCA, Ecole Nationale Veterinaire de Nantes, BP 50707, 44307 Nantes Cedex 3, France
    Rapid Commun Mass Spectrom 17:1256-64. 2003
    ..genistein, daidzein, equol, formononetin, biochanin A), lignans (enterolactone, enterodiol), and coumestans (coumestrol) was investigated...
  34. ncbi Administration of estrogen receptor beta-specific selective estrogen receptor modulators to the hippocampus decrease anxiety and depressive behavior of ovariectomized rats
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Pharmacol Biochem Behav 86:407-14. 2007
    ..ERbeta (17alpha-E(2) or propyl pyrazole triol), or SERMs with greater affinity for ERbeta vs. ERalpha (coumestrol or diarylpropionitrile) to these sites (2 microg/microl/side) before testing in anxiety (open field, elevated ..
  35. ncbi Cell-transforming activity and mutagenicity of 5 phytoestrogens in cultured mammalian cells
    Takeki Tsutsui
    Department of Pharmacology, The Nippon Dental University, School of Dentistry at Tokyo, Tokyo, Japan
    Int J Cancer 105:312-20. 2003
    ..of phytoestrogens, the abilities of 5 phytoestrogens, daidzein, genistein, biochanin A, prunetin, and coumestrol, to induce cell transformation and genetic effects were examined using the Syrian hamster embryo (SHE) cell ..
  36. ncbi Estrogen and phytoestrogen regulate the mRNA expression of adrenomedullin and adrenomedullin receptor components in the rat uterus
    Kazuhiro Ikeda
    Department of Environmental Medicine, Center for Community Medicine, Jichi Medical School, Yakushiji 3311 1, Minamikawachi Machi, Kawachi gun, Tochigi 329 0498, Japan
    Mol Cell Endocrinol 223:27-34. 2004
    ..known to be a component of the adrenomedullin (ADM) receptor, as responsive to both E2 and the phytoestrogen coumestrol (Cou)...
  37. ncbi The effect of two dietary and a synthetic phytoestrogen on transepithelial calcium transport in human intestinal-like Caco-2 cells
    Alice A Cotter
    Dept of Food and Nutritional Sciences, University College, Cork, Ireland
    Eur J Nutr 44:72-8. 2005
    ..While PEs act directly on bone cells, their protective effect on bone may be partly due to their ability to enhance Ca absorption...
  38. ncbi Urinary phytoestrogen excretion of rats bearing methylnitrosourea-induced mammary carcinoma in response to treatment with 2-methoxyestradiol
    T H Lippert
    Section of Clinical Pharmacology, Department of Obstetrics and Gynecology, University of Tuebingen, Germany
    J Steroid Biochem Mol Biol 103:158-62. 2007
    ..These results suggest that the high levels of catechol estrogens, produced by 2-MeE2 treatment, may have influenced the urinary excretion pattern of phytoestrogens...
  39. ncbi Puerariafuran, a new inhibitor of advanced glycation end products (AGEs) isolated from the roots of Pueraria lobata
    Dae Sik Jang
    Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine, 461 24 Jeonmin dong, Yuseong Gu, Daejon 305 811, Korea
    Chem Pharm Bull (Tokyo) 54:1315-7. 2006
    A new 2-arylbenzofuran, puerariafuran (1), as well as three known compounds, coumestrol (2), daidzein (3), and genistein (4), were isolated from a MeOH extract of the roots of Pueraria lobata as active constituents, using an in vitro ..
  40. ncbi Coumestrol, bisphenol-A, DDT, and TCDD modulation of interleukin-2 expression in activated CD+4 Jurkat T cells
    Kenneth Ndebele
    Molecular Toxicology Research Laboratory, NIH Center for Environmental Health, School of Science and Technology, Jackson State University, Jackson, Mississippi, USA
    Int J Environ Res Public Health 1:3-11. 2004
    ..These responses may be modulated by xenoestrogens such as coumestrol, bisphenol A (BPA), DDT, and TCDD...
  41. ncbi Differential response to phytoestrogens in endocrine sensitive and resistant breast cancer cells in vitro
    Jane L Limer
    Leeds Institute for Molecular Medicine, University of Leeds, St James s University Hospital, Leeds, United Kingdom
    Int J Cancer 119:515-21. 2006
    ..was to investigate the proliferative effects and mode of action of the phytoestrogens genistein, daidzein and coumestrol on TAM-sensitive (-s) and resistant (-r) breast cancer cells under in vitro conditions designed to mimic the ..
  42. ncbi ERbeta-selective SERMs produce mnemonic-enhancing effects in the inhibitory avoidance and water maze tasks
    Madeline E Rhodes
    Department of Psychology, The University at Albany SUNY, 1400 Washington Avenue, Social Sciences 369, Albany, NY 12222, USA
    Neurobiol Learn Mem 85:183-91. 2006
    ..triol (PPT) or 17alpha-E2, the ERbeta-specific SERMs, diarylpropionitrile (DPN) or 7,12-dihydrocoumestan (coumestrol), or vehicle (oil)...
  43. ncbi Combinatory effects of phytoestrogens and 17beta-estradiol on proliferation and apoptosis in MCF-7 breast cancer cells
    Simone Schmidt
    Institut für Kreislaufforschung und Sportmedizin, Abt molekulare und zelluläre Sportmedizin, Deutsche Sporthochschule Koln, 50927 Koln, Germany
    J Steroid Biochem Mol Biol 94:445-9. 2005
    ..have analysed the dose dependent combinatory activity of the phytoestrogens genistein (Gen), daidzein (Dai) and coumestrol (Cou), and 17beta-estradiol (E2) on cell proliferation and apoptosis induction in human MCF-7 breast cancer ..
  44. pmc Xenoestrogens at picomolar to nanomolar concentrations trigger membrane estrogen receptor-alpha-mediated Ca2+ fluxes and prolactin release in GH3/B6 pituitary tumor cells
    Ann L Wozniak
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555 0645, USA
    Environ Health Perspect 113:431-9. 2005
    ..plastics manufacturing by-products/detergents (nonylphenol, bisphenol A), a phytoestrogen (coumestrol), and a synthetic estrogen (diethylstilbestrol) on the pituitary tumor cell subline GH3/B6/F10, previously ..
  45. ncbi Modulation of tumor formation and intestinal cell migration by estrogens in the Apc(Min/+) mouse model of colorectal cancer
    Sara H Javid
    Department of Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Carcinogenesis 26:587-95. 2005
    ..Phytoestrogens, including the soy isoflavone genistein and coumestrol, are used by many women as alternatives to HRT...
  46. ncbi The effect of the phytoestrogen coumestrol on the NZB/W F1 murine model of systemic lupus
    Leeanne J Schoenroth
    Faculty of Medicine, HRB 410B, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    J Autoimmun 23:323-32. 2004
    b>Coumestrol is a naturally occurring plant estrogen...
  47. ncbi Antimicrobial isoflavonoids from Erythrina crista galli infected with Phomopsis sp
    Flavia Redko
    Instituto de Química y Metabolismo del Fármaco IQUIMEFA UBA CONICET, Catedra de Farmacognosia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, 1113 Buenos Aires, Argentina
    Z Naturforsch C 62:164-8. 2007
    The isoflavonoids coumestrol, genistein and daidzein have been isolated and identified by bioassay-guided fractionation from the acetone extract of Erythrina crista galli young twigs infected with Phomopsis sp...
  48. ncbi Effects of the phytoestrogen coumestrol on RANK-ligand-induced differentiation of osteoclasts
    Sanae Kanno
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicology 203:211-20. 2004
    ..In this study, we investigated the effects of coumestrol and other phytoestrogens on osteoclast differentiation using estrogen receptor alpha-transfected RAW264...
  49. ncbi Reciprocal mutagenesis between human alpha(L349, M528) and rainbow trout (M317, I496) estrogen receptor residues demonstrates their importance in ligand binding and gene expression at different temperatures
    J B Matthews
    Department of Biochemistry and Molecular Biology, Institute for Environmental Toxicology and National Food Safety and Toxicology Center, Michigan State University, 223 Biochemistry Building, Wilson Road, East Lansing, MI 48824-1319, USA
    Mol Cell Endocrinol 183:127-39. 2001
    ..ability at higher temperatures, and displayed hER alpha phenotypic behavior for the phytoestrogen, coumestrol. The hER alpha def L349M:M528I double mutant also exhibited a modest trend towards adopting the rtER phenotype...
  50. ncbi Detection of phytoestrogens in samples of second trimester human amniotic fluid
    Warren G Foster
    Center for Women s Health, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Toxicol Lett 129:199-205. 2002
    ..Analytes included the phytoestrogens daidzein, genistein, formononetin, biochanin A, and coumestrol. Dietary phytoestrogens were quantified in 96.2% of second trimester amniotic fluid samples tested...
  51. ncbi Molecular identification of potential selective estrogen receptor modulator (SERM) like properties of phytoestrogens in the human breast cancer cell line MCF-7
    P Diel
    , , Germany
    Planta Med 67:510-4. 2001
    ..For this reason we have investigated potential SERM-like properties of the phytoestrogens daidzein (Dai), coumestrol (Cou), and genistein (Gen) in the human breast cancer cell line MCF-7...
  52. ncbi Comparison of the oestrogenic effects of infant milk formulae, oestradiol and the phytoestrogen coumestrol delivered continuously in the drinking water to ovariectomised mice
    V J Pocock
    Endocrinology and Reproduction Research Group, School of Biomedical Sciences, Guy s Campus, King s College, London SE1 1UL, UK
    Food Chem Toxicol 40:643-51. 2002
    The potential oestrogenic effects of infant milk formulae, coumestrol and oestradiol delivered in the drinking water were investigated in ovariectomised mice...
  53. ncbi Synthesis and cytotoxic activity of new 2,4-diaryl-4H,5H-pyrano[3,2-c]benzopyran-5-ones on MCF-7 cells
    Y Jacquot
    Service de Chimie Thérapeutique, Faculte de Medecine et de Pharmacie, Laboratoire d Oncologie et d Endocrinologie Moléculaire, Besancon, France
    Pharmazie 57:233-7. 2002
    ..These results were compared with those of coumestrol, a phytoestrogen structurally close to 2,4-diaryl-4H,5H-pyrano[3,2-c]benzopyran-5-ones, and with RU 58668, a ..
  54. ncbi The influence of coumestrol, zearalenone, and genistein administration on insulin receptors and insulin secretion in ovariectomized rats
    L Nogowski
    Department of Animal Physiology and Biochemistry, August Cieszkowski University of Agriculture, Wołyńska 35, PL 60 637 Poznań, Poland
    J Recept Signal Transduct Res 22:449-57. 2002
    The influence of phytoestrogens (genistein and coumestrol) and mycoestrogen (zearalenone) on insulin secretion, liver insulin receptors and some aspects of lipid and carbohydrate metabolism were investigated in this study...
  55. ncbi Quantitative determination of isoflavones and coumestrol in soybean by column liquid chromatography
    L S Hutabarat
    Department of Food Science and Technology, University of New South Wales, Sydney, Australia
    J Chromatogr A 886:55-63. 2000
    ..Daidzein, genistein, formononetin, biochanin A and coumestrol were separated within 24 min on a phenyl column with acetonitrile-water (33:67, v/v) as eluent...
  56. ncbi Prenatal exposure to estrogenic compounds alters the expression pattern of platelet-derived growth factor receptors alpha and beta in neonatal rat testis: identification of gonocytes as targets of estrogen exposure
    Raphael Thuillier
    Division of Hormone Research, Department of Cell Biology, Georgetown University School of Medicine, Washington, District of Columbia 20057, USA
    Biol Reprod 68:867-80. 2003
    ..treated from gestation Day 14 to birth with corn oil containing diethylstilbestrol, bisphenol A, genistein, or coumestrol by gavage or subcutaneous injection...
  57. ncbi Theoretical concepts of on-line liquid chromatographic-biochemical detection systems. I. Detection systems based on labelled ligands
    A J Oosterkamp
    Leiden/Amsterdam Center for Drug Research, University of Leiden, The Netherlands
    J Chromatogr A 787:27-35. 1997
    ..It was found that the response of the RAD system is correlated with the affinity of the injected compounds and that the relative affinity order of binding ligands is maintained in the RAD system...
  58. ncbi Common phytochemicals are ecdysteroid agonists and antagonists: a possible evolutionary link between vertebrate and invertebrate steroid hormones
    E Oberdorster
    Tulane Xavier Center for Bioenvironmental Research, Tulane University, 1430 Tulane Avenue, SL 3, New Orleans, LA 70124, USA
    J Steroid Biochem Mol Biol 77:229-38. 2001
    ..four flavones: luteolin and quercetin (metabolites of rutin), and apigenin and chrysin; and three non-flavones, coumestrol and genistein (both estrogenic) and tomatine (alters molt in insects)...
  59. ncbi Effects of phytoestrogens on testosterone secretion by Leydig cells from Biłgoraj ganders (Anser anser)
    Dr M Opalka
    Department of Animal Physiology, University of Warmia and Mazury in Olsztyn, Poland
    Br Poult Sci 47:237-45. 2006
    ..Isolated Leydig cells were incubated with LH as well as genistein, daidzein, equol and coumestrol and the concentration of testosterone in the medium was determined by radioimmunoassay...
  60. ncbi Stimulation of alkaline phosphatase activity in Ishikawa cells induced by various phytoestrogens and synthetic estrogens
    Jannette Wober
    Molecular Cell Physiology and Endocrinology, Institute of Zoology, Dresden University of Technology, Mommsenstr 13, 01062 Dresden, Germany
    J Steroid Biochem Mol Biol 83:227-33. 2002
    ..We measured the relative estrogenic potency of phytoestrogens (genistein, daidzein, coumestrol, some naringenins), synthetic estrogens (bisphenol A, octylphenol, nonylphenol, o,p'-DDT), mycoestrogen (..
  61. pmc Impact of the phytoestrogen content of laboratory animal feed on the gene expression profile of the reproductive system in the immature female rat
    Jorge M Naciff
    Miami Valley Laboratories, The Procter and Gamble Company, Cincinnati, Ohio 45253 8707, USA
    Environ Health Perspect 112:1519-26. 2004
    ..Phytoestrogens, including genistein, daidzein, and coumestrol, are fairly abundant in soybeans and alfalfa, common ingredients of laboratory animal diets...
  62. ncbi Determination of phytoestrogens in dietary supplements by LC-MS/MS
    D B Clarke
    Department for Environment, Food and Rural Affairs, Central Science Laboratory, Sand Hutton, York, UK
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 25:534-47. 2008
    ..The content of total isoflavones per dose ranged from <1 to 53 mg. Trace amounts of coumestrol were found in six products...
  63. ncbi Assessing phytoestrogen exposure in epidemiologic studies: development of a database (United States)
    P L Horn-Ross
    Northern California Cancer Center, Union City 94587, USA
    Cancer Causes Control 11:289-98. 2000
    ..The purpose of this research was to develop such a database for use with food-frequency questionnaires in large epidemiologic studies...
  64. ncbi Interaction of phytoestrogens and other environmental estrogens with prostaglandin synthase in vitro
    G H Degen
    Institute of Toxicology, University of Wurzburg, F R G
    J Steroid Biochem 35:473-9. 1990
    The phytoestrogens daidzein, genistein, equol and coumestrol were found to stimulate microsomal prostaglandin H synthase (PHS) in vitro in a concentration-dependent manner when PHS-activity was measured by arachidonic acid-dependent ..
  65. ncbi Rapid yeast estrogen bioassays stably expressing human estrogen receptors alpha and beta, and green fluorescent protein: a comparison of different compounds with both receptor types
    Toine F H Bovee
    RIKILT Institute of Food Safety, P O Box 230, AE Wageningen 6700, The Netherlands
    J Steroid Biochem Mol Biol 91:99-109. 2004
    ..The phytoestrogens coumestrol, genistein, genistin, daidzein, daidzin and naringenin were relatively more potent with ERbeta...
  66. ncbi Phytoestrogen content of foods consumed in Canada, including isoflavones, lignans, and coumestan
    Lilian U Thompson
    Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
    Nutr Cancer 54:184-201. 2006
    ..formononetin), lignans (secoisolariciresinol, matairesinol, pinoresinol, lariciresinol), and coumestan (coumestrol) using gas chromatography-mass spectrometry methods...
  67. ncbi Effect of diet on fecal and urinary estrogenic activity
    H A Tucker
    Department of Dairy Science, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Dairy Sci 93:2088-94. 2010
    ..4 and 35.6 mg/d). Analysis by LC-MS/MS indicated greater fecal excretion of equol, genistein, daidzein, coumestrol, and formononetin by heifers fed red clover hay (1634, 29.9, 96.3, 27...
  68. ncbi ERbeta-selective estrogen receptor modulators produce antianxiety behavior when administered systemically to ovariectomized rats
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    Neuropsychopharmacology 30:1598-609. 2005
    ..ERbeta-selective SERMs were diarylpropionitrile (DPN) and 7,12-dihydrocoumestan (coumestrol). DPN is more selective at ERbeta than coumestrol, which also binds ERalpha...
  69. ncbi High resolution screening of plant natural product extracts for estrogen receptor alpha and beta binding activity using an online HPLC-MS biochemical detection system
    U Schobel
    ScreenTec B V, Leiden, The Netherlands
    J Biomol Screen 6:291-303. 2001
    ..to conventional microtiter-type bioassays, the interactions of the extracts with the ER and the employed label, coumestrol, proceeded at high speed in a closed, continuous-flow reaction detection system, which was coupled directly to ..
  70. ncbi Activation of estrogen receptor alpha and ERbeta by 4-methylbenzylidene-camphor in human and rat cells: comparison with phyto- and xenoestrogens
    Stefan O Mueller
    Institute of Toxicology, Merck KGaA, 64271 Darmstadt, Germany
    Toxicol Lett 142:89-101. 2003
    ..4-MBC showed lower estrogenic potency than genistein, coumestrol, resveratrol, bisphenol A and also camphor...
  71. pmc Relative potency of xenobiotic estrogens in an acute in vivo mammalian assay
    S R Milligan
    Physiology, Biomedical Sciences Division, King s College, London, United Kingdom
    Environ Health Perspect 106:23-6. 1998
    ..b>Coumestrol was the most active phytoestrogen, with an ED 50 between 10 -6 and 10 -7 mol; genistein was about 10-fold less ..
  72. ncbi Dietary consumption of phytochemicals and breast cancer risk in Mexican women
    Luisa Torres-Sanchez
    Instituto Nacional de Salud Publica, Av Universidad No 655, Col Sta Maria Ahuacatitlan, CP 62508, Cuernavaca, Morelos, Mexico
    Public Health Nutr 12:825-31. 2009
    ..To perform an evaluation of selected phytochemicals intake and breast cancer (BC) risk in Mexican women...
  73. ncbi Pueraria mirifica phytoestrogens improve dyslipidemia in postmenopausal women probably by activating estrogen receptor subtypes
    Shinichi Okamura
    Department of Medical Informatics and Decision Sciences, School of Medicine, Gunma University, Maebashi, Japan
    Tohoku J Exp Med 216:341-51. 2008
    ..Among PM phytoestrogens, miroestrol and coumestrol enhanced both ERalpha- and ERbeta-mediated transactivation, whereas other phytoestrogens, including daidzein and ..
  74. ncbi Antioxidant efficacy of phytoestrogens in chemical and biological model systems
    J H Mitchell
    Division of Micronutrients and Lipid Metabolism, Rowett Research Institute, Bucksburn, AB21 9SB, UK
    Arch Biochem Biophys 360:142-8. 1998
    ..b>Coumestrol and equol were more effective antioxidants than genistein but had relatively limited activity in comparison with ..
  75. ncbi Competitive binding of xenobiotic oestrogens to rat alpha-fetoprotein and to sex steroid binding proteins in human and rainbow trout (Oncorhynchus mykiss) plasma
    S R Milligan
    Physiology Group, Biomedical Sciences Division, King s College London, Strand, London, WC2R 2LS, United Kingdom
    Gen Comp Endocrinol 112:89-95. 1998
    ..f. oestradiol). All other compounds (phytooestrogens: coumestrol, daidzein, genistein; others: 4-nonylphenol, 4-tert-octylphenol, 4-nonylphenoldiethoxylate, 4-tert-butylphenol, ..
  76. ncbi Development and validation of fluorescent receptor assays based on the human recombinant estrogen receptor subtypes alpha and beta
    Theo de Boer
    MERSKA BV, L J Zielstraweg 1, 9713 GX Groningen, The Netherlands
    J Pharm Biomed Anal 34:671-9. 2004
    ..As a labelled ligand an autofluorescent phyto-estrogen (coumestrol) has been used...
  77. ncbi Modification of phenolic metabolism in soybean hairy roots through down regulation of chalcone synthase or isoflavone synthase
    Vera V Lozovaya
    Department of Crop Sciences, University of Illinois, 1201 W Gregory Drive, Urbana, IL 61801, USA
    Planta 225:665-79. 2007
    ..The isoflavone and coumestrol concentrations were decreased by about 90% in most lines apparently due to gene silencing...
  78. ncbi Effects of phytoestrogens and environmental estrogens on osteoblastic differentiation in MC3T3-E1 cells
    Sanae Kanno
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicology 196:137-45. 2004
    ..In this study, we report the effects of phytoestrogens (genistein, daidzein, and coumestrol) and environmental estrogens (bisphenol A (BPA), p-n-nonylphenol (NP) and bis(2-ethylhexyl)phthalate (DEHP)) on ..
  79. ncbi Inhibition of 17beta-hydroxysteroid oxidoreductase by flavonoids in breast and prostate cancer cells
    S Makela
    Institute of Biomedicine, University of Turku, Finland
    Proc Soc Exp Biol Med 217:310-6. 1998
    ..Regarding prevention or treatment of estrogen-related diseases, apigenin, coumestrol, and genistein raise special interest.
  80. ncbi Estrogenic activities of isoflavones and flavones and their structure-activity relationships
    Sun Young Choi
    Food Function Research Group, Korea Food Research Institute, Gyeonggi Do, Republic of Korea
    Planta Med 74:25-32. 2008
    ..Genistein and coumestrol in the yeast transactivation assay and biochanin A, genistein, and equol in the E-screen assay, have been shown ..
  81. ncbi [Exposure of phytoestrogens intake through diet in a sample of females]
    J Hernández-Elizondo
    Departamento de Nutricion y Bromatologia, Universidad de Granada, Granada, Espana
    Nutr Hosp 24:445-51. 2009
    ....
  82. pmc Dietary intake of polyphenols, nitrate and nitrite and gastric cancer risk in Mexico City
    Raúl U Hernández-Ramírez
    Center of Population Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico
    Int J Cancer 125:1424-30. 2009
    ..High intakes of cinnamic acids, secoisolariciresinol and coumestrol were associated with an approximately 50% reduction in GC risk...
  83. ncbi Development of a high-throughput LC/APCI-MS method for the determination of thirteen phytoestrogens including gut microbial metabolites in human urine and serum
    Ciska Wyns
    Laboratory of Pharmacognosy and Phytochemistry, Ghent University Ugent, Harelbekestraat 72, B 9000 Gent, Belgium
    J Chromatogr B Analyt Technol Biomed Life Sci 878:949-56. 2010
    ..most important gut microbial metabolites (genistein, daidzein, equol, dihydrodaidzein, O-desmethylangolensin, coumestrol, secoisolariciresinol, matairesinol, enterodiol, enterolactone, isoxanthohumol, xanthohumol and 8-..
  84. ncbi Estrogenic effects of mixtures of phyto- and synthetic chemicals on uterine growth of prepubertal rats
    J A van Meeuwen
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Toxicol Lett 170:165-76. 2007
    ..determined in the rat juvenile uterotrophic assay using a predefined phytochemical mixture (PCmix) containing coumestrol, genistein, naringenin, (+,-)catechin, (-,-)epicatechin and quercetin, and a predefined synthetic chemical ..
  85. ncbi Global gene expression profiles induced by phytoestrogens in human breast cancer cells
    Ramiro Dip
    Institute of Pharmacology and Toxicology, University of Zurich Vetsuisse, Winterthurerstrasse 260, Zurich, Switzerland
    Endocr Relat Cancer 15:161-73. 2008
    ..Highly congruent responses were also observed by comparing the physiologic estradiol with daidzein, coumestrol, enterolactone, or resveratrol, each representing distinct phytoestrogen structures...
  86. ncbi Lignan content of selected foods from Japan
    José L Peñalvo
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center and Division of Clinical Chemistry, University of Helsinki, 00014 Helsinki, Finland
    J Agric Food Chem 56:401-9. 2008
    ..Together with isoflavones and coumestrol, enterolignans have been traditionally classified as phytoestrogens, plant-derived compounds that exhibit ..
  87. ncbi New cytotoxic prenylated isoflavonoids from Bituminaria morisiana
    Filippo Cottiglia
    Dipartimento Farmaco Chimico Tecnologico, Faculty of Pharmacy, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
    Planta Med 71:254-60. 2005
    ..daidzein, 8-prenyldaidzein and bidwillon C, one known furocoumarin, pseudoisopsoralen and one known coumestan, coumestrol were isolated...
  88. ncbi Computational discovery of novel low micromolar human pregnane X receptor antagonists
    Sean Ekins
    Collaborations in Chemistry, Jenkintown, PA 19046, USA
    Mol Pharmacol 74:662-72. 2008
    ..our computational pharmacophore and docking tools to suggest that most of the known PXR antagonists, such as coumestrol and sulforaphane, could also interact on the outer surface of PXR at the AF-2 domain...
  89. pmc Reversed-phase liquid chromatography coupled on-line to estrogen receptor bioaffinity detection based on fluorescence polarization
    Jelle Reinen
    Department of Chemistry and Pharmaceutical Sciences, LACDR Division of Molecular Toxicology, Vrije Universiteit, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands
    Anal Bioanal Chem 390:1987-98. 2008
    ..of five compounds known to be estrogenic (17beta-estradiol, 17alpha-ethinylestradiol and the phytoestrogens coumestrol, coumarol and zearalenone), followed by post-column bioaffinity screening of the individual affinities for ..
  90. ncbi Simple and sensitive liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of five Epimedium prenylflavonoids in rat sera
    Ping Shen
    Department of Obstetrics and Gynecology, National University Hospital, Yong Loo Lin School of Medicine, National University of Singapore, Republic of Singapore
    J Chromatogr B Analyt Technol Biomed Life Sci 877:71-8. 2009
    ..Serum samples were extracted with ethyl acetate without further derivatization. Using coumestrol as an internal standard, calibration curves with good linearity (r(2)>0...
  91. ncbi AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids
    Lucie Skarydová
    Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic
    Chem Biol Interact 178:138-44. 2009
    ..g. indomethacin or flufenamic acid. Also dietary phytoestrogens such as coumestrol, quercetin, and biochanin were reported to inhibit the enzyme in low micromolar concentrations...
  92. ncbi Screening of the inhibitory effect of vegetable constituents on the aryl hydrocarbon receptor-mediated activity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Yoshiaki Amakura
    Division of Foods, National Institute of Health Sciences, Tokyo, Japan
    Biol Pharm Bull 26:1754-60. 2003
    ..were assayed in vitro. Among them, flavones, flavonols, anthraquinones, piperine, coumestrol, brevifolincarboxylic acid, and resveratrol showed marked inhibitory effects on AhR-based bioassay activation by ..
  93. ncbi Vampire bat reproductive control by a naturally occurring phytooestrogen
    Hector Serrano
    Department of Health Sciences, Metropolitan Autonomous University Iztapalapa, Ave San Rafael Atlixco 186, Mexico City 09340, DF, Mexico
    Reprod Fertil Dev 19:470-2. 2007
    ..After collection, bats were fed bovine blood containing 200 microg coumestrol for a 30-day period. After treatment, gonads were excised and processed for histological evaluation...
  94. ncbi An efficient synthesis of coumestrol and coumestans by iodocyclization and Pd-catalyzed intramolecular lactonization
    Tuanli Yao
    Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA
    J Org Chem 70:9985-9. 2005
    ..The iodocyclization of acetoxy-containing 2-(1-alkynyl)anisoles and subsequent direct palladium-catalyzed carbonylation/lactonization provide an efficient route to naturally occurring coumestan and coumestrol, and their related analogues.
  95. ncbi Effects of estrogen, androgen, and phytoestrogen on retrieving and licking behaviors in nulliparous and male rats
    Mariko Sakai
    Neuroendocrinology, Department of Human Behavior and Environment Sciences, School of Human Sciences, Waseda University, 2 579 15, Mikajima, Tokorozawa, Saitama 359 1192, Japan
    Zoolog Sci 24:894-8. 2007
    ..pups in ovariectomized nulliparous rats, 1 mg estradiol benzoate (EB), 1 mg testosterone propionate (TP), 1 mg coumestrol (CM), or oil (female control) was injected subcutaneously daily for 10 days...
  96. ncbi Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens
    Ramiro Dip
    Institute of Pharmacology and Toxicology, University of Zurich Vetsuisse, Zurich, Switzerland
    Food Chem Toxicol 47:787-95. 2009
    ..model for molecular processes associated with breast cancer, were exposed to a sub-saturating concentration of coumestrol either alone or in combination with analogs that exhibit 1000-fold lower estrogen receptor activity...
  97. ncbi Assessing phytochemical intake in a group of Mexican women
    Marcia V Galvan-Portillo
    Mexico s National Institute of Public Health, Cuernavaca, Morelos, Mexico
    Salud Publica Mex 49:126-31. 2007
    ..Identify the content of selected phytochemicals (PHYs) in Mexican foods and evaluate the reliability of a food frequency questionnaire (FFQ) in assessing PHYs intake among Mexican women...
  98. pmc Phytoestrogen consumption from foods and supplements and epithelial ovarian cancer risk: a population-based case control study
    Elisa V Bandera
    Cancer Prevention and Control Program Division of Surgical Oncology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    BMC Womens Health 11:40. 2011
    ..While there is extensive literature evaluating the impact of phytoestrogen consumption on breast cancer risk, its role on ovarian cancer has received little attention...
  99. ncbi Dietary phytoestrogens, including isoflavones, lignans, and coumestrol, in nonvitamin, nonmineral supplements commonly consumed by women in Canada
    Lilian U Thompson
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada M5S 3E2
    Nutr Cancer 59:176-84. 2007
    ..daidzein, genistein, glycitein), lignans (pinoresinol, lariciresinol, secoisolariciresinol, matairesinol), and coumestrol to complement our previously published food phytoestrogen database...
  100. ncbi Development of a food compositional database for the estimation of dietary intake of phyto-oestrogens in a group of postmenopausal women previously treated for breast cancer and validation with urinary excretion
    Don B Clarke
    Emergency Response and Recovery Programme, Food and Environment Research Agency, Sand Hutton, York YO41 1LZ, UK
    Br J Nutr 109:2261-8. 2013
    ..the determination of dietary intakes of specific PE (daidzein, genistein, glycitein, formononetin, biochanin A, coumestrol, matairesinol and secoisolariciresinol), in a group of women previously diagnosed and treated for postmenopausal ..
  101. ncbi The protective effects of coumestrol against amyloid-β peptide- and lipopolysaccharide-induced toxicity on mice astrocytes
    Man Hai Liu
    School of Pharmacy, Taipei Medical University, Taiwan
    Neurol Res 33:663-72. 2011
    ..Phytoestrogens have been proposed as potential alternatives to estrogen replacement therapy. The purpose of this study was to evaluate the in vitro protective effects of coumestrol on mice astrocytes.

Research Grants17

  1. Sex-specific gene regulation of neuronal chloride co-transporter, kcc2
    WOLFGANG B LIEDTKE; Fiscal Year: 2010
    ..physiologically relevant concentrations of estradiol and practically relevant concentrations of xeno-estrogens (coumestrol, bisphenol-A, dieldrin)...
  2. Phytoestrogens and Cancer
    Wesley Gray; Fiscal Year: 2009
    ..1, that has not previously known to be regulated by PE. This gene is selectively activated by genistein and coumestrol but not by estradiol. Furthermore, its expression is PE specific and estrogen receptor (ER) dependent...
  3. Chemical Modulation of Orphan Nuclear Receptor Function
    Sridhar Mani; Fiscal Year: 2013
    ..Towards this end, we have identified and characterized two novel PXR antagonists, ketoconazole and coumestrol, that specifically disrupt the function of activated (ligand-bound) PXR...
  4. Phytoestrogens, alcohol, and endometrial cancer risk
    ELISA BANDERA; Fiscal Year: 2007
    ..This award will provide the support and training the Candidate needs to develop an independent career in the nutritional epidemiology of cancer. ..
  5. Nongenomic Signaling Mechanisms of Environmental Estrogens
    Cheryl S Watson; Fiscal Year: 2011
    ..breast and pituitary cancers, infertility) must be understood so that exposures can be limited to safe levels. ..
  6. Environmental Estrogens Acting via a Membrane Receptor
    CHERYL WATSON; Fiscal Year: 2004
    ..abstract_text> ..
  7. Interactive Effects of Flaxseed and Tamoxifen in Breast*
    Lilian Thompson; Fiscal Year: 2004
    ..abstract_text> ..
  8. Mid-life Aging and Urinary Incontinence in a Multi-Ethn*
    L Waetjen; Fiscal Year: 2009
    ..abstract_text> ..
  9. CAM Use in Midlife Women in Five Ethnic Groups
    Ellen Gold; Fiscal Year: 2005
    ..abstract_text> ..
  10. SWAN Sleep Study II-UC Davis/Kaiser site
    Ellen Gold; Fiscal Year: 2008
    ..The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances. ..
  11. Sex Steroids & Mammographic Density in the Postmenopause
    Gail Greendale; Fiscal Year: 2007
    ..We will quantify the relations between the hormone and genetic exposures measured in this project and mammographic density (at baseline as well as change in density between baseline and 12 months). ..
  12. The Yoga for Hyperkyphosis Trial
    Gail Greendale; Fiscal Year: 2007
    ..At the end of this phase we will again measure study endpoints to assess whether participants have maintained the physical function achieved at the end of the RCT. ..
  13. Liquid Chromatography Mass Spectrometry system
    Adrian Franke; Fiscal Year: 2005
    ..abstract_text> ..
  14. Plant Foods and Endometrial Cancer Epidemiology
    PAMELA HORN ROSS; Fiscal Year: 2005
    ..A priori definitions and factor analysis will be used to identify dietary patterns. The results of the proposed analyses will provide further understanding of the etiology of endometrial cancer. ..
  15. Scutellaria baicalensis and Colon Cancer Chemoprevention
    Diane Harris; Fiscal Year: 2005
    ..abstract_text> ..
  16. Nutrition and Thyroid Cancer Risk in the CTS Cohort
    PAMELA HORN ROSS; Fiscal Year: 2007
    ..The results of this research will have important implications for improving our understanding of the etiology of this disease which disproportionately affects young women. [unreadable] [unreadable] [unreadable]..