coumarins

Summary

Summary: Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid. The various coumarins have a wide range of proposed actions and uses including as ANTICOAGULANTS, pharmaceutical aids, indicators and reagents, photoreactive substances, and ANTINEOPLASTIC AGENTS.

Top Publications

  1. ncbi The structure and pharmacological functions of coumarins and their derivatives
    Longhuo Wu
    Engineering Research Center of Molecular Medicine, Ministry of Education, Huaqiao University Main Campus, Quanzhou, China 362021
    Curr Med Chem 16:4236-60. 2009
  2. doi Antioxidant activities of coumarins from Korean medicinal plants and their structure-activity relationships
    Phuong Thien Thuong
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Phytother Res 24:101-6. 2010
  3. ncbi Anti-oxidative and photo-protective effects of coumarins isolated from Fraxinus chinensis
    Bum Chun Lee
    College of Pharmacy, Chungbuk National University, Cheongju 361 763, Korea
    Arch Pharm Res 30:1293-301. 2007
  4. ncbi Synthesis and biological evaluation of functionalized coumarins as acetylcholinesterase inhibitors
    Qiong Shen
    School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou 510275, China
    Eur J Med Chem 40:1307-15. 2005
  5. ncbi Simple coumarins and analogues in medicinal chemistry: occurrence, synthesis and biological activity
    F Borges
    Unidade de Química Física Molecular Laboratório de Química Organica, Faculdade de Farmacia, Universidade do Porto, 4050 047 Porto, Portugal
    Curr Med Chem 12:887-916. 2005
  6. doi Poly(lactide)-vitamin E derivative/montmorillonite nanoparticle formulations for the oral delivery of Docetaxel
    Si Shen Feng
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Block E5, 02 11, 4 Engineering Drive 4, Singapore 117576, Singapore
    Biomaterials 30:3297-306. 2009
  7. pmc Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase
    M Gellert
    Proc Natl Acad Sci U S A 73:4474-8. 1976
  8. ncbi Synthetic and natural coumarins as cytotoxic agents
    Irena Kostova
    Department of Chemistry, Faculty of Pharmacy, Medical University, 2 Dunav St, Sofia 1000, Bulgaria
    Curr Med Chem Anticancer Agents 5:29-46. 2005
  9. doi Lactoferrin-conjugated PEG-PLA nanoparticles with improved brain delivery: in vitro and in vivo evaluations
    Kaili Hu
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, 200032, People s Republic of China
    J Control Release 134:55-61. 2009
  10. doi The use of coumarins as environmentally-sensitive fluorescent probes of heterogeneous inclusion systems
    Brian D Wagner
    Department of Chemistry, University of Prince Edward Island, Charlottetown, PE, Canada
    Molecules 14:210-37. 2009

Research Grants

Detail Information

Publications349 found, 100 shown here

  1. ncbi The structure and pharmacological functions of coumarins and their derivatives
    Longhuo Wu
    Engineering Research Center of Molecular Medicine, Ministry of Education, Huaqiao University Main Campus, Quanzhou, China 362021
    Curr Med Chem 16:4236-60. 2009
    b>Coumarins are of many different structures...
  2. doi Antioxidant activities of coumarins from Korean medicinal plants and their structure-activity relationships
    Phuong Thien Thuong
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Phytother Res 24:101-6. 2010
    The aim of this work was to study the structure-activity relationships of the antioxidant activity of natural coumarins isolated from four Korean medicinal plants (1-17) and four purchased coumarins (18-21)...
  3. ncbi Anti-oxidative and photo-protective effects of coumarins isolated from Fraxinus chinensis
    Bum Chun Lee
    College of Pharmacy, Chungbuk National University, Cheongju 361 763, Korea
    Arch Pharm Res 30:1293-301. 2007
    ..From these results, FCE and one of its components, esculetin, were predicted to be potentially useful as ingredients in cosmetics for protecting against photoaging...
  4. ncbi Synthesis and biological evaluation of functionalized coumarins as acetylcholinesterase inhibitors
    Qiong Shen
    School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou 510275, China
    Eur J Med Chem 40:1307-15. 2005
    ..19+/-0.01 microM and a high selectivity for AChE/BuChE, and compound 6b acted as non-competitive AChE inhibitor with IC50 value of 0.43+/-0.02 microM. Structure-activity relationships (SARs) of prepared compounds were discussed...
  5. ncbi Simple coumarins and analogues in medicinal chemistry: occurrence, synthesis and biological activity
    F Borges
    Unidade de Química Física Molecular Laboratório de Química Organica, Faculdade de Farmacia, Universidade do Porto, 4050 047 Porto, Portugal
    Curr Med Chem 12:887-916. 2005
    b>Coumarins, also known as benzopyrones, are present in remarkable amounts in plants, although their presence has also been detected in microorganisms and animal sources...
  6. doi Poly(lactide)-vitamin E derivative/montmorillonite nanoparticle formulations for the oral delivery of Docetaxel
    Si Shen Feng
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Block E5, 02 11, 4 Engineering Drive 4, Singapore 117576, Singapore
    Biomaterials 30:3297-306. 2009
    ..59% for Taxotere((R)) to 78% for the PLA-TPGS/MMT NP formulation and 91% for the PLA-TPGS NP formulation respectively. Oral chemotherapy by nanoparticles of biodegradable polymers is feasible...
  7. pmc Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase
    M Gellert
    Proc Natl Acad Sci U S A 73:4474-8. 1976
    ..We conclude that DNA gyrase controls the supercoiling of DNA in E. coli...
  8. ncbi Synthetic and natural coumarins as cytotoxic agents
    Irena Kostova
    Department of Chemistry, Faculty of Pharmacy, Medical University, 2 Dunav St, Sofia 1000, Bulgaria
    Curr Med Chem Anticancer Agents 5:29-46. 2005
    b>Coumarins, an old class of compounds, are naturally occurring benzopyrene derivatives. A lot of coumarins have been identified from natural sources, especially green plants...
  9. doi Lactoferrin-conjugated PEG-PLA nanoparticles with improved brain delivery: in vitro and in vivo evaluations
    Kaili Hu
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, 200032, People s Republic of China
    J Control Release 134:55-61. 2009
    ..Cell viability experiment results confirmed good safety of the biodegradable Lf-NP. The significant in vitro and in vivo results suggest that Lf-NP is a promising brain drug delivery system with low toxicity...
  10. doi The use of coumarins as environmentally-sensitive fluorescent probes of heterogeneous inclusion systems
    Brian D Wagner
    Department of Chemistry, University of Prince Edward Island, Charlottetown, PE, Canada
    Molecules 14:210-37. 2009
    b>Coumarins, as a family of molecules, exhibit a wide range of fluorescence emission properties...
  11. pmc Converging pharmacological and genetic evidence indicates a role for steroid sulfatase in attention
    William Davies
    Behavioural Genetics Group, School of Psychology and Department of Psychological Medicine, School of Medicine, University of Cardiff, London, United Kingdom
    Biol Psychiatry 66:360-7. 2009
    ..Preliminary work in mice and humans has suggested the X-linked gene STS (which encodes the enzyme steroid sulfatase) as a mediator of attentional functioning and as a candidate gene for ADHD...
  12. doi Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-alpha, and COX-2 expression in mouse macrophage RAW 264.7
    Tomonori Nakamura
    Department of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260 8675, Japan
    J Nat Med 63:21-7. 2009
    ..It was expected that these compounds show anti-inflammatory activities...
  13. ncbi VKORC1: molecular target of coumarins
    J Oldenburg
    Institute for Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Bonn, Germany
    J Thromb Haemost 5:1-6. 2007
    ..VKORC1 is the key enzyme of the vitamin K cycle and the molecular target of coumarins, which represent the most commonly prescribed drugs for therapy and prevention of thromboembolic conditions...
  14. doi Osthole suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt/mTOR pathway
    Victor Chia Hsiang Lin
    Department of Urology, E Da Hospital, Department of Nursing, I Shou University, Kaohsiung, Taiwan
    J Agric Food Chem 58:4786-93. 2010
    ..These results suggested that osthole has the potential to advance as chemopreventive or chemotherapeutic agent for cancers that overexpress HER2...
  15. ncbi Cationic albumin-conjugated pegylated nanoparticles as novel drug carrier for brain delivery
    Wei Lu
    Department of Pharmaceutics, School of Pharmacy, Fudan University Fenglin Campus, Shanghai 200032, People s Republic of China
    J Control Release 107:428-48. 2005
    ..The significant results in vitro and in vivo showed that CBSA-NP was a promising brain drug delivery carrier with low toxicity...
  16. ncbi Brain delivery property and accelerated blood clearance of cationic albumin conjugated pegylated nanoparticle
    Wei Lu
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, 200032, People s Republic of China
    J Control Release 118:38-53. 2007
    ..Understanding these issues is important for the future development of CBSA-NP as a brain delivery carrier and for the attenuation of toxicity or immunological responses to the nanodevice following a consequence of nanomedication...
  17. doi Anticonvulsant and acute neurotoxic effects of imperatorin, osthole and valproate in the maximal electroshock seizure and chimney tests in mice: a comparative study
    Jarogniew J Luszczki
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Epilepsy Res 85:293-9. 2009
    ....
  18. doi Antimicrobial and antioxidant activities of coumarins from the roots of Ferulago campestris (Apiaceae)
    Adriana Basile
    Dipartimento delle Scienze Biologiche, Sezione di Biologia Vegetale, Universita Federico II, Via Foria 223, 80139 Napoli, Italy
    Molecules 14:939-52. 2009
    We report the isolation of several coumarins and the stereochemical assessment of some pyranocoumarins, as well as the antibacterial and antioxidant activities of the three most abundant ones (grandivittin, agasyllin and aegelinol ..
  19. doi Preparation and brain delivery property of biodegradable polymersomes conjugated with OX26
    Zhiqing Pang
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, PR China
    J Control Release 128:120-7. 2008
    ..v. administration. These results indicated that OX26(34)-PO is a promising carrier for peptide brain delivery...
  20. ncbi Evaluation of auraptene content in citrus fruits and their products
    K Ogawa
    Department of Citriculture, National Institute of Fruit Tree Science, Ministry of Agriculture, Forestry and Fisheries, Okitsu, Shimizu, Shizuoka 424 0292, Japan
    J Agric Food Chem 48:1763-9. 2000
    ..49 mg/g) and in the juice sac (1.73 mg/g). Citrus fruit products, for example, brand-named grapefruit juice and marmalade, retain about 0. 1 mg and 0.3 mg/100 g of auraptene, respectively...
  21. ncbi Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities
    Arunrat Sunthitikawinsakul
    Planta Med 69:155-7. 2003
    Four known coumarins, dentatin (1), nor-dentatin (2), clausenidin (3) and xanthoxyletin (5), and six known carbazole derivatives, 3-formylcarbazole (6), mukonal (7), 3-methoxycarbonylcarbazole (8), murrayanine (9), 2-hydroxy-3-formyl-7-..
  22. ncbi Antibacterial activity of crude extracts from Mexican medicinal plants and purified coumarins and xanthones
    Kakuko Yasunaka
    Department of Microbiology and Immunology, School of Medicine, Fukuoka University, Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    J Ethnopharmacol 97:293-9. 2005
    ..Clusiaceae), and Mammea americana L. (Clusiaceae) were highly active against Staphylococcus aureus. Coumarins (mammea A/BA and mammea A/AA) and xanthones, namely jacareubin and 1,3,5,6-tetrahydroxy-2-(3,3-dimethylallyl) ..
  23. pmc Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action
    Ruth H Flatman
    Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK
    Antimicrob Agents Chemother 49:1093-100. 2005
    ..This is a novel mechanism for a gyrase inhibitor and presents new possibilities for antibacterial drug development...
  24. doi Inhibition of topoisomerase IIα: novel function of wedelolactone
    Petr Benes
    Department of Experimental Biology, Faculty of Science, Masaryk University, Czech Republic
    Cancer Lett 303:29-38. 2011
    ..Wedelolactone interacted with dsDNA and inhibited the activity of DNA topoisomerase IIα. We conclude that wedelolactone can act as growth suppressor independently of NFκB and androgen receptors...
  25. ncbi Inhibitory effects of coumarins from the stem barks of Fraxinus rhynchophylla on adipocyte differentiation in 3T3-L1 cells
    Eunjin Shin
    College of Pharmacy, Chungbuk National University, Cheongju, Korea
    Biol Pharm Bull 33:1610-4. 2010
    ..Activity-guided fractionation led to the isolation of six coumarins such as esculetin (1), scopoletin (2), fraxetin (3), fraxidin (4) esculin (5) and fraxin (6)...
  26. ncbi Auraptene: a natural biologically active compound with multiple targets
    Salvatore Genovese
    Dipartimento di Scienze del Farmaco, Università G d Annunzio di Chieti Pescara, Via dei Vestini 31, Chieti Scalo CH, Italy
    Curr Drug Targets 12:381-6. 2011
    ....
  27. doi Inhibition of snake venoms and phospholipases A(2) by extracts from native and genetically modified Eclipta alba: isolation of active coumestans
    Luciana C Diogo
    Department of Biotechnology, University of Ribeirao Preto, Ribeirao Preto, Sao Paulo, Brazil
    Basic Clin Pharmacol Toxicol 104:293-9. 2009
    ..The search for antivenom is justified by the need of finding active principles that are more efficient in neutralizing snake venoms and also as an attempt to complement serum therapy...
  28. doi Osthole and imperatorin, the active constituents of Cnidium monnieri (L.) Cusson, facilitate glutamate release from rat hippocampal nerve terminals
    Su Jane Wang
    School of Medicine, Fu Jen Catholic University, Hsin Chuang, Taipei Hsien 24205, Taiwan
    Neurochem Int 53:416-23. 2008
    ..Together, these results suggest that osthole or imperatorin effects a facilitation of glutamate release from nerve terminals by positively modulating N-and P/Q-type Ca(2+) channel activation through a signaling cascade involving PKC...
  29. ncbi The cytotoxic properties of natural coumarins isolated from roots of Ferulago campestris (Apiaceae) and of synthetic ester derivatives of aegelinol
    Sergio Rosselli
    Dipartimento Chimica Organica E Paternò, Universita di Palermo, Viale delle Scienze, Parco d Orleasn II, 90128 Palermo, Italy
    Nat Prod Commun 4:1701-6. 2009
    Grandivittin (1), agasyllin (2), aegelinol benzoate (3) and felamidin (20), four natural coumarins isolated from Ferulago campestris, and several synthetic ester derivatives of aegelinol (4) were tested against four tumor cell lines...
  30. ncbi A safety assessment of coumarin taking into account species-specificity of toxicokinetics
    S P Felter
    The Procter and Gamble Company, Miami Valley Innovation Center, 11810 E Miami River Road, Cincinnati, OH 45252, USA
    Food Chem Toxicol 44:462-75. 2006
    ....
  31. ncbi Isolation of 8'-phosphate ester derivatives of amicoumacins: structure-activity relationship of hydroxy amino acid moiety
    Makoto Hashimoto
    Reseach Institute of Pharmaceutical Sciences, Musashino University, Shinmachi, Nishitokyo, Tokyo, Japan
    J Antibiot (Tokyo) 60:752-6. 2007
    ..Comparison of the antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) of these compounds suggested that C-8' hydroxyl and C-12' amide group of amicoumacin A played a critical role for anti-MRSA activity...
  32. ncbi Cytotoxic activity of coumarins from the fruits of Cnidium monnieri on leukemia cell lines
    Ling Ling Yang
    School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan, ROC
    Planta Med 69:1091-5. 2003
    ..Then, the CmF extract was subjected to silica gel column chromatography and recrystallization to give five coumarins: osthol, imperatorin, bergapten, isopimpinellin, and xanthotoxin...
  33. ncbi Inhibition of gastric H+,K+-ATPase activity by flavonoids, coumarins and xanthones isolated from Mexican medicinal plants
    Ricardo Reyes-Chilpa
    Instituto de Quimica, Universidad Nacional Autonoma de Mexico, D F Mexico, Mexico
    J Ethnopharmacol 105:167-72. 2006
    ..the properties of some of their chemical constituents, four natural xanthones, an acetylated derivative, two coumarins (mammea A/BA and mammea C/OA) isolated from Calophyllum brasiliense Cambess and two flavonoids (minimiflorin and ..
  34. doi A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyrase
    Marcus J Edwards
    Department of Biological Chemistry, John Innes Centre, Colney, Norwich NR4 7UH, UK
    Science 326:1415-8. 2009
    ..Our results should facilitate the design of drug molecules that target these unexploited binding pockets...
  35. ncbi Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tü 6040
    Ute Galm
    Pharmazeutische Biologie, Pharmazeutisches Institut, Auf der Morgenstelle 8, 72076 Tubingen, Germany
    Arch Microbiol 178:102-14. 2002
    ..Feeding of the mutant with the aminocoumarin moiety of novobiocin led to a new, artificial simocyclinone derivative...
  36. ncbi Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex
    M Kobori
    Department of Cell Biology, Harvard Medical School, Boston, MA, USA
    Cell Death Differ 11:123-30. 2004
    ..We demonstrate that wedelolactone is an inhibitor of IKK, a kinase critical for activation of NF-kappaB by mediating phosphorylation and degradation of IkappaBalpha...
  37. ncbi 7,8-Dihydroxy-4-methylcoumarin induces apoptosis of human lung adenocarcinoma cells by ROS-independent mitochondrial pathway through partial inhibition of ERK/MAPK signaling
    Anita Goel
    Molecular Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, Mall Road, Delhi 110 007, India
    FEBS Lett 581:2447-54. 2007
    b>Coumarins have attracted intense interest in recent years because they have been identified from natural sources, especially green plants and have diverse pharmacological properties...
  38. doi Apoptogenic effect of 7,8-diacetoxy-4-methylcoumarin and 7,8-diacetoxy-4-methylthiocoumarin in human lung adenocarcinoma cell line: role of NF-kappaB, Akt, ROS and MAP kinase pathway
    Anita Goel
    Molecular Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India
    Chem Biol Interact 179:363-74. 2009
    Coumarin (1,2-benzopyrone) is a naturally occurring fragrant compound found in a variety of plants and spices. Coumarins have attracted intense interest in recent years because of their diverse pharmacological activities...
  39. ncbi Dietary administration with prenyloxycoumarins, auraptene and collinin, inhibits colitis-related colon carcinogenesis in mice
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 118:2936-42. 2006
    ..Our findings may suggest that certain prenyloxycoumarins, such as auraptene and collinin, could serve as an effective agent against colitis-related colon cancer development in rodents...
  40. ncbi Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by citrus auraptene in rats
    T Tanaka
    First Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Carcinogenesis 19:425-31. 1998
    ....
  41. ncbi Aggressive behavior induced by the steroid sulfatase inhibitor COUMATE and by DHEAS in CBA/H mice
    L B Nicolas
    , , Comportement, , , , France
    Brain Res 922:216-22. 2001
    ..These results confirm the correlation between aggressive behavior and STS concentration in mice. In addition, we confirm that the steroid metabolism can modulate the behavior in rodents...
  42. pmc Fluorescent single-stranded DNA binding protein as a probe for sensitive, real-time assays of helicase activity
    Mark S Dillingham
    DNA Protein Interactions Unit, Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    Biophys J 95:3330-9. 2008
    ..Its use in the study of DNA manipulations involving ssDNA intermediates is demonstrated in assays for DNA unwinding, catalyzed by DNA helicases...
  43. pmc Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic
    A Trefzer
    Pharmazeutische Biologie, Albert Ludwigs Universitat Freiburg, 79104 Freiburg, Germany
    Antimicrob Agents Chemother 46:1174-82. 2002
    ..Production of simocyclinone D8 was clearly detectable in the wild-type strain but was not detectable in the mutant strains. This indicated that indeed the sim gene cluster had been cloned...
  44. ncbi Calibrated automated thrombin generation measurement in clotting plasma
    H Coenraad Hemker
    Synapse BV, Cardiovascular Research Institute, University of Maastricht, Maastricht, The Netherlands
    Pathophysiol Haemost Thromb 33:4-15. 2003
    ....
  45. ncbi Accumulation of coumarins in Arabidopsis thaliana
    Kosuke Kai
    Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611 0011, Japan
    Phytochemistry 67:379-86. 2006
    The biosynthesis of coumarins in plants is not well understood, although these metabolic pathways are often found in the plant kingdom. We report here the occurrence of coumarins in Arabidopsis thaliana ecotype Columbia...
  46. doi Structures of the TetR-like simocyclinone efflux pump repressor, SimR, and the mechanism of ligand-mediated derepression
    Tung B K Le
    Department of Molecular Microbiology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK
    J Mol Biol 408:40-56. 2011
    ....
  47. ncbi Antiproliferative effects of isopentenylated coumarins isolated from Phellolophium madagascariense Baker
    C Riviere
    Institut de Chimie Pharmaceutique Albert Lespagnol, EA2692, rue J Laguesse, BP 83, F 59006 Lille, France
    Nat Prod Res 20:909-16. 2006
    From the leaves of Phellolophium madagascariense Baker (Apiaceae), an endemic herb to Madagascar, three known coumarins (osthol, murraol and meranzin hydrate) have been isolated and identified...
  48. pmc In vitro anti-Helicobacter pylori activity of the probiotic strain Bacillus subtilis 3 is due to secretion of antibiotics
    I V Pinchuk
    , ENITA de Bordeaux, 33175 Gradignan Cedex, France
    Antimicrob Agents Chemother 45:3156-61. 2001
    ..An additive effect between amicoumacin A and the nonamicoumacin antibiotic against H. pylori was demonstrated...
  49. ncbi Effects of osthole on migration and invasion in breast cancer cells
    Dapeng Yang
    Department of Developmental Genetics, Nanjing Medical University, China
    Biosci Biotechnol Biochem 74:1430-4. 2010
    ..This is the first report on the inhibitory function of Osthole in migration and invasion in breast cancer cells. Our findings indicate a need for further evaluation of Osthole in breast cancer chemotherapy and chemoprevention...
  50. ncbi Antitumor effects of Osthol from Cnidium monnieri: an in vitro and in vivo study
    Szu Yuan Chou
    Department of Obstetrics and Gynecology, Taipei Medical University Wan Fang Medical Center, Taipei, Taiwan
    Phytother Res 21:226-30. 2007
    ..formosanum Yabe of Taiwan's endemic plants contained little osthol, with no imperatorin, and its major components were different from that of C. monnieri. Therefore, it is suggested that C. formosanum also may possess economic worth...
  51. doi Attenuation of experimental autoimmune encephalomyelitis in C57 BL/6 mice by osthole, a natural coumarin
    Xiaohong Chen
    Department of Neurology, The Third Affiliated Hospital, Sun Yat Sen University, 600 Tianhe Road, Guangzhou, Guangdong 510630, China
    Eur J Pharmacol 629:40-6. 2010
    ..In addition, osthole blocked the reduction of NGF and suppressed IFN-gamma increase in EAE mice. These results suggested that osthole might be a new pharmacological approach to treat multiple sclerosis...
  52. ncbi Osthole-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells
    Po Lin Kuo
    Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
    J Pharmacol Exp Ther 314:1290-9. 2005
    ..In this study, we demonstrate that osthole is a promising agent for treating osteoporosis...
  53. doi Coupling of the biosynthesis and export of the DNA gyrase inhibitor simocyclinone in Streptomyces antibioticus
    Tung B K Le
    Department of Molecular Microbiology, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    Mol Microbiol 72:1462-74. 2009
    ..In addition, an intermediate in the biosynthetic pathway, simocyclinone C4, which is essentially inactive as a DNA gyrase inhibitor, also induces simX expression in vivo and relieves simX repression by SimR in vitro...
  54. ncbi Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas
    Yong Yook Lee
    Natural Products Research Institute, Seoul National University, Seoul 110 460, Korea
    Arch Pharm Res 26:723-6. 2003
    Five coumarins, isoimperatorin (1), pabulenol (2), isooxypeucedanin (3), oxypeucedanin hydrate (4) and osthol (5) were isolated from the MeOH extract of Angelica genuflexa in the course of searching for anti-platelet and anti-coagulant ..
  55. ncbi Immunomodulatory and anti-inflammatory activity of selected osthole derivatives
    Michał Zimecki
    Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, R Weigla str 12, 53 114, Wroclaw, Poland
    Z Naturforsch C 64:361-8. 2009
    ..5% and 68.3% inhibition, respectively). In summary, the compounds predominantly displayed suppressive and antiinflammatory activities in the investigated models...
  56. ncbi Citrus auraptene suppresses azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db mice
    Kei Hayashi
    Department of Surgical Oncology, Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Oshikawaa 020 0903, Japan
    Nutr Cancer 58:75-84. 2007
    ....
  57. doi Increased bleeding risk with concurrent use of selective serotonin reuptake inhibitors and coumarins
    Tom Schalekamp
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Arch Intern Med 168:180-5. 2008
    Treatment with vitamin K antagonists (coumarins) is associated with an increased risk of bleeding...
  58. pmc In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus
    Lisa M Oppegard
    Department of Pharmacology, University of Minnesota Medical School Twin Cities, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Antimicrob Agents Chemother 53:2110-9. 2009
    ....
  59. ncbi Detecting Hg2+ ions with an ICT fluorescent sensor molecule: remarkable emission spectra shift and unique selectivity
    Jiaobing Wang
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China
    J Org Chem 71:4308-11. 2006
    ..This sensor, employing the ICT mechanism, could be used to specifically detect Hg2+ ions in a neutral buffered water solution with an approximately 100-nm blue shift in emission spectra...
  60. doi Hair growth promoting activity of Eclipta alba in male albino rats
    R K Roy
    Department of Pharmaceutical Sciences, Dr HS Gour University, Sagar, MP, India
    Arch Dermatol Res 300:357-64. 2008
    ..The result of treatment with 2 and 5% petroleum ether extracts were better than the positive control minoxidil 2% treatment...
  61. doi A novel dimeric coumarin analog and antimycobacterial constituents from Fatoua pilosa
    Chun Ching Chiang
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, R O C
    Chem Biodivers 7:1728-36. 2010
    ....
  62. ncbi Antiproliferative effect of isopentenylated coumarins on several cancer cell lines
    S Kawaii
    Laboratory of Bio-organic Chemistry, Tokyo Denki University, Hatoyama, Saitama, Japan
    Anticancer Res 21:1905-11. 2001
    33 coumarins, mainly the simple isopentenylated coumarins and derived pyrano- and furanocoumarins, were examined for their antiproliferative activity towards several cancer and normal human cell lines...
  63. doi Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors
    Alfonso Maresca
    Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm 188, Via della Lastruccia 3, I 50019 Sesto Fiorentino, Florence, Italy
    J Am Chem Soc 131:3057-62. 2009
    ..The inhibition is time dependent, with maximum inhibition being observed after 6 h...
  64. doi Antifungal activities of new coumarins
    Ahmed A Al-Amiery
    Chemical Engineering Faculty, University of Kabengassan Malaysia UKM, Selangor 43000, Malaysia
    Molecules 17:5713-23. 2012
    Newly synthesized coumarins 4-((5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)-methoxy)-2H-chromen-2-one and 4-((5-(phenylamino)-1,3,4-thiadiazol-2-yl)-methoxy)-2H-chromen-2-one were tested against selected types of fungi and showed ..
  65. doi Quantification of flavoring constituents in cinnamon: high variation of coumarin in cassia bark from the German retail market and in authentic samples from indonesia
    Friederike Woehrlin
    Federal Institute for Risk Assessment, Thielallee 88 92, 14195 Berlin, Germany
    J Agric Food Chem 58:10568-75. 2010
    ..Interestingly, a high variation was observed in one of the trees, whereas no coumarin was detected in the samples of two other trees. In conclusion, coumarin levels in cassia cinnamon can vary widely even within a single tree...
  66. ncbi New pyranocoumarins isolated from Calophyllum lanigerum and Calophyllum teysmannii
    T C McKee
    Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, NCI FCRDC, Frederick, Maryland 21702 1201, USA
    J Nat Prod 59:754-8. 1996
    ..F. Stevens (Clusiaceae). The structure elucidation and anti-HIV activity of calanolide E2 (4), cordatolide E (5), pseudocordatolide C (6), and calanolide F (9), along with a simple prenylated coumarin precursor (11), are described here...
  67. ncbi Cytotoxic coumarins from the root of Angelica dahurica
    Pham Ngoc Thanh
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Arch Pharm Res 27:1211-5. 2004
    Ten coumarins were isolated from the root of Angelica dahurica by repeated silica gel column chromatography. Their chemical structures were elucidated on the basic of physicochemical and spectroscopic data...
  68. ncbi Coumarins: old compounds with novel promising therapeutic perspectives
    M E Riveiro
    Laboratorio de Patología y Farmacología Molecular, Instituto de Biologia y Medicina Experimental, Vuelta de Obligado 2490 C1428DN, Buenos Aires, Argentina
    Curr Med Chem 17:1325-38. 2010
    Natural as well as synthetic coumarins have recently drawn much attention due to its broad pharmacological activities...
  69. ncbi Single-dose methoxsalen effects on human cytochrome P-450 2A6 activity
    E D Kharasch
    Department of Anesthesiology, University of Washington, Seattle 98195, USA
    Drug Metab Dispos 28:28-33. 2000
    ..Alternative doses, timing, and/or routes of methoxsalen administration are required for greater, longer, and more reproducible CYP2A6 inhibition than that provided by single-dose methoxsalen...
  70. ncbi Furanocoumarins from the root of Angelica dahurica
    N I Baek
    Department of Life Sciences and Institute of Life Sciences, Kyunghee University, Suwon, Korea
    Arch Pharm Res 23:467-70. 2000
    ..This represents the first study in which the compound 2 has been isolated and identified. The long-range coupling (5J) in the 1H-NMR spectrum observed in the linear furanocoumarin skeleton was also investigated in detail...
  71. ncbi Sesquiterpene coumarins from Ferula fukanensis and nitric oxide production inhibitory effects
    Tsunetake Motai
    College of Pharmacy, Nihon University, 7 7 1 Narashinodai, Funabashi, Chiba 274 8555, Japan
    J Nat Prod 67:432-6. 2004
    ..7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma)...
  72. doi Toxicology and risk assessment of coumarin: focus on human data
    Klaus Abraham
    Federal Institute for Risk Assessment BfR, 14195 Berlin, Germany
    Mol Nutr Food Res 54:228-39. 2010
    ..Heavy consumers of cassia cinnamon may reach a daily coumarin intake corresponding to the TDI...
  73. doi Alkaloid and coumarins from the green fruits of Aegle marmelos
    Suda Chakthong
    Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
    Phytochemistry 75:108-13. 2012
    ..Antifungal and antibacterial activities of selected compounds were also evaluated...
  74. ncbi HPLC comparison of supercritical fluid extraction and solvent extraction of coumarins from the peel of Citrus maxima fruit
    Wen Yuh Teng
    Department of Agricultural Chemistry, National Taiwan University, Taipei
    Phytochem Anal 16:459-62. 2005
    ..Under the best SFE conditions tested for the three coumarins, which involved extraction at 50 degrees C and 27...
  75. ncbi Antioxidant activity of coumarins and flavonols from the resinous exudate of Haplopappus multifolius
    Rene Torres
    Departamento de Ciencias del Ambiente, Fascultad de Química y Biología, Universidad de Santiago de Chile, Avda Bernardo O Higgins 3363, Santiago, Chile
    Phytochemistry 67:984-7. 2006
    The antioxidant activity of eight coumarins and two flavonols isolated from Haplopappus multifolius was studied with the DPPH radical method...
  76. ncbi Dihydrochalcones and coumarins of Esenbeckia grandiflora subsp. brevipetiolata
    M Trani
    Centro Chimica dei Recettori, C N R, Istituto di Chimica, U C S C, Largo Francesco Vito 1, Roma 00168, Italy
    Fitoterapia 75:99-102. 2004
    Six furoquinolines and five coumarins have been isolated from the roots of Esenbeckia grandiflora subsp. brevipetiolata. The leaves yielded two dihydrochalcones and two flavonol rhamnosides...
  77. ncbi In vitro GABA-transaminase inhibitory compounds from the root of Angelica dahurica
    Soo Young Choi
    Department of Biomedical Sciences, Division of Life Sciences, Hallym University, Chuncheon 200 702, Korea
    Phytother Res 19:839-45. 2005
    ..Repeated column chromatography for the EtOAc and n-BuOH fractions led to the isolation of two new coumarins, oxypeucedanin hydrate-3''-butyl ether and isopraeroside IV along with six known coumarins, isoimperatorin, ..
  78. ncbi Xenobiotic reductase A in the degradation of quinoline by Pseudomonas putida 86: physiological function, structure and mechanism of 8-hydroxycoumarin reduction
    Julia J Griese
    Laboratorium Proteinkristallographie, Universitat Bayreuth, Germany
    J Mol Biol 361:140-52. 2006
    ..putida strains unable to degrade quinoline, it appears to have more than one physiological function and is an example of how enzymes with low substrate specificity can help to explain the variety of degradation pathways possible...
  79. doi Biflavanones, flavonoids, and coumarins from the roots of Stellera chamaejasme and their antiviral effect on hepatitis B virus
    Guohong Yang
    Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 200032, P R China
    Chem Biodivers 5:1419-24. 2008
    ..Their structures and configurations were elucidated by spectroscopic methods including 2D-NMR techniques. Sikokianin A, chamaechromone, and quercetin showed in vitro antiviral activity against HBsAg secretion...
  80. doi Application of beta-oxodithioesters in domino and multicomponent reactions: facile route to dihydropyrimidines and coumarins
    Okram Mukherjee Singh
    Department of Chemistry, Manipur University, Canchipur 795003, India
    J Org Chem 74:3141-4. 2009
    ..The methodology involves the three-component Biginelli reaction. On the other hand, substituted salicylaldehyde and beta-oxodithioesters reacted under the same condition to afford the substituted 2H-chromene-2-thiones in high yields...
  81. doi Simultaneous characterization and quantitation of 11 coumarins in Radix Angelicae Dahuricae by high performance liquid chromatography with electrospray tandem mass spectrometry
    Xuguang Zheng
    Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang 050017, China
    J Pharm Biomed Anal 51:599-605. 2010
    ..By using this HPLC-ESI-MS/MS method, all 11 coumarins were separated and determined within 10min...
  82. doi In vitro and in vivo investigation of glucose-mediated brain-targeting liposomes
    Yao Qin
    Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu, People s Republic of China
    J Drug Target 18:536-49. 2010
    ..43 times higher than that of LIP, and 3.10 times higher than that of CLP. Both pharmacokinetics and distribution in mice were also investigated to show that this novel brain targeting drug delivery system was promising...
  83. doi Two new coumarins from Murraya paniculata
    Sumayya Saied
    Department of Chemistry, University of Karachi, Karachi, Pakistan
    J Asian Nat Prod Res 10:515-9. 2008
    Two new coumarins, murrmeranzin (1) and murralonginal (2), together with four known compounds minumicrolin (3), murrangatin (4), meranzin hydrate (5) and hainanmurpanin (6) have been isolated from the aerial parts of Murraya paniculata...
  84. doi Simultaneous analysis of coumarins and secoiridoids in Cortex Fraxini by high-performance liquid chromatography-diode array detection-electrospray ionization tandem mass spectrometry
    Lei Zhou
    The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, No 38 Xueyuan Road, Beijing 100083, PR China
    J Pharm Biomed Anal 47:39-46. 2008
    ..The results indicated that the developed method could be considered to be a simple, rapid and reliable method for the quality evaluation of Cortex Fraxini...
  85. doi Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II
    Alfonso Maresca
    Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Sesto Fiorentino Firenze, Italy
    Bioorg Med Chem Lett 20:4511-4. 2010
    A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties in positions 3-, 4-, 6- and 7- of the heterocyclic ring were investigated for the inhibition of the zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1)...
  86. ncbi Protection of coumarins against linoleic acid hydroperoxide-induced cytotoxicity
    Takao Kaneko
    Redox Regulation Research Group, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo 173 0015, Japan
    Chem Biol Interact 142:239-54. 2003
    b>Coumarins comprise a group of natural phenolic compounds found in a variety of plant sources...
  87. doi Biologically active sesquiterpene coumarins from Ferula species
    Zeinab Esmail Nazari
    Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Phytother Res 25:315-23. 2011
    ..antiviral, P-glycoprotein (P-gp) inhibitory and antiinflammatory activity have been attributed to sesquiterpene coumarins; structures containing a common coumarin group and a sesquiterpene moiety...
  88. ncbi Antibacterial and anticoagulant activities of coumarins isolated from the flowers of Magydaris tomentosa
    Sergio Rosselli
    Dipartimento di Chimica Organica, Universita degli Studi di Palermo, Palermo, Italy
    Planta Med 73:116-20. 2007
    ..DC afforded six known coumarins as well as (+)-meranzin hydrate (7), not previously reported as a natural product...
  89. ncbi Cytotoxic Coumarins from the Bark of Mammea siamensis
    Ngoc Trang Nhu Ngo
    Ho Chi Minh City University of Science, Ho Chi Minh City, Vietnam
    Chem Pharm Bull (Tokyo) 58:1487-91. 2010
    ..named surangin D), was isolated from the bark of Mammea siamensis collected in Vietnam, along with four known coumarins, surangins B and C, and theraphins B and C, and seven xanthones, 1,7-dihydroxyxanthone, 7-hydroxy-1-..
  90. doi 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range
    Alfonso Maresca
    Universita degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Sesto Fiorentino Firenze, Italy
    Bioorg Med Chem Lett 20:7255-8. 2010
    Two series of disubstituted coumarins incorporating ether and acetyl/propionyl moieties in positions 6,7- and 7,8- of the heterocyclic ring were synthesized investigated for the inhibition of the zinc enzyme carbonic anhydrase (CA, EC 4...
  91. ncbi Inhibition of leukemic cell growth by a novel anti-cancer drug (GUT-70) from calophyllum brasiliense that acts by induction of apoptosis
    Shinya Kimura
    Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan
    Int J Cancer 113:158-65. 2005
    ..Thus, a novel anti-cancer drug, GUT-70 isolated from the stem bark of C. brasiliense induces caspase-mediated and p53-independent apoptosis to overcome multidrug resistance and may become a potent leukemia therapeutics...
  92. ncbi Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tü 6040 II. Structure elucidation and biosynthesis
    Meike Holzenkämpfer
    Institut fur Organische Chemie, Universitat Gottingen, Germany
    J Antibiot (Tokyo) 55:301-7. 2002
    ..The structure elucidation was done by one and two dimensional NMR experiments, and other spectroscopic methods in combination with incorporation experiments using 13C labelled precursors...
  93. ncbi Isolation of coumarins and ferulate from the roots of Angelica purpuraefolia and the antitumor activity of khellactone
    Hyeong Kyu Lee
    Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
    Phytother Res 21:406-9. 2007
    ..fraction of the roots of Angelica purpuraefolia, along with one ferulate (2) and three other known coumarins (3-5) including khellactone (3)...
  94. doi Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase
    Angela Stefanachi
    Dipartimento Farmaco Chimico, Università degli Studi di Bari Aldo Moro, Via Orabona 4, I 70125 Bari, Italy
    J Med Chem 54:1613-25. 2011
    ..identification of the most important interactions driving the binding and clearly indicated the allowed and disallowed regions for appropriate structural modifications of coumarins and closely related heterocyclic molecular scaffolds.
  95. doi Identification and quantification of coumarins in Peucedanum ostruthium (L.) Koch by HPLC-DAD and HPLC-DAD-MS
    Sylvia Vogl
    Department of Pharmacognosy, University of Vienna, Vienna, Austria
    J Agric Food Chem 59:4371-7. 2011
    ..HPLC-DAD-MS) method has been developed for the simultaneous identification and quantification of its main coumarins, oxypeucedanin hydrate, oxypeucedanin, ostruthol, imperatorin, osthole, isoimperatorin, and ostruthin...
  96. doi Knoevenagel reaction in [MMIm][MSO₄]: synthesis of coumarins
    Pedro Verdía
    Department of Organic Chemistry, Faculty of Chemistry, University of Vigo, Pontevedra 36310, Spain
    Molecules 16:4379-88. 2011
    ..When L-proline is used as an additional promoter to obtain coumarins from o-hydroxybenzaldehydes, the reaction also proceeds in high yields...
  97. ncbi Synthesis of coumarins, 4-hydroxycoumarins, and 4-hydroxyquinolinones by tellurium-triggered cyclizations
    Donald C Dittmer
    Department of Chemistry, Syracuse University, Room 1 014 CST, Syracuse, New York 13244, USA
    J Org Chem 70:4682-6. 2005
    b>Coumarins, 4-hydroxycoumarins, and 4-hydroxyquinolin-2(1H)-ones can be conveniently prepared by treatment of alpha-halocarboxylic acid esters of salicylaldehyde, o-hydroxyacetophenone, methyl salicylate, and methyl N-methyl- or N-..
  98. ncbi Recent advances in coumarins and 1-azacoumarins as versatile biodynamic agents
    Manohar V Kulkarni
    Department of Applied Chemistry, National Chiao Tung University, Hsinchu 300 50, Taiwan
    Curr Med Chem 13:2795-818. 2006
    b>Coumarins, also referred as benzopyran-2-ones, and their corresponding nitrogen counterpart, 1-azacoumarins also referred to as carbostyrils, are a family of nature-occurring lactones and lactams respectively...
  99. doi The Au(I)-catalyzed intramolecular hydroarylation of terminal alkynes under mild conditions: application to the synthesis of 2H-chromenes, coumarins, benzofurans, and dihydroquinolines
    Rajeev S Menon
    Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Canberra, ACT 0200, Australia
    J Org Chem 74:8901-3. 2009
    ....
  100. ncbi Antinociceptive properties of coumarins, steroid and dihydrostyryl-2-pyrones from Polygala sabulosa (Polygalaceae) in mice
    Flavia Carla Meotti
    Departamento de Quimica, Universidade Federal de Santa Maria, 97110 000, Santa Maria, RS Brazil
    J Pharm Pharmacol 58:107-12. 2006
    ..sabulosa that produced marked antinociception against the acetic acid-induced visceral nociceptive response, supporting the ethnomedical use of P. sabulosa...
  101. doi Polarity-sensitive coumarins tailored to live cell imaging
    Giovanni Signore
    Center for Nanotechnology Innovation, p za San Silvestro 12, I 56127 Pisa, Italy
    J Am Chem Soc 132:1276-88. 2010
    ..We set up a robust synthetic procedure tunable on the substitution patterns to achieve. These coumarins possess excellent fluorescence quantum yields (up to 0...

Research Grants89

  1. NATURAL & SYNTHETIC COUMARINS AS ANTICARCINOGENIC AGENTS
    John DiGiovanni; Fiscal Year: 2002
    ..We have recently found that several natural, as well as novel synthetic coumarins, have the potential to be effective inhibitors of mouse skin carcinogenesis by PAHs...
  2. Analysis of Phenolic Phytochemical by ESI-MS
    Jennifer Brodbelt; Fiscal Year: 2003
    ..quantitation of flavonoids in kale, soy, and urine, the second involving the identification and quantitation of coumarins in urine and tissue, the third involving the quantitation and identification of tocopherol compounds in tissue, ..
  3. Anticarcinogenic effects of naturally occurring coumarins on mammary carcinogenes
    HEATHER KLEINER HANCOCK; Fiscal Year: 2007
    ..Award will enable me to study the extent and mechanisms of the inhibitory effects of naturally occurring coumarins (NOCs) and 1'-acetoxychavicol acetate (ACA) in human and rodent models of mammary carcinogenesis...
  4. Pilot-Scale Heterocyclic and Carbocyclic Libraries for High Throughout Screening
    RICHARD LAROCK; Fiscal Year: 2007
    ..alkenes and arynes will be employed to prepare specially diverse libraries of indoles, benzofurans, benzopyrans, coumarins, isocoumarins, phthalides, pyrones, 2-quinolones, pyridines, isoquinolin-1-ones, isoindolin-1-ones, ..
  5. Dual Direct Inhibitors of Thrombin and Factor Xa
    Umesh Desai; Fiscal Year: 2009
    ..Anticoagulants, including heparins and coumarins, are the mainstay of treatment and prevention of thromboembolic disorders...
  6. Dual Direct Inhibitors of Thrombin and Factor Xa
    UMESH RAMANLAL DESAI; Fiscal Year: 2010
    ..Anticoagulants, including heparins and coumarins, are the mainstay of treatment and prevention of thromboembolic disorders...
  7. Synthesis of Medicinally Important Heterocycles
    RICHARD LAROCK; Fiscal Year: 2007
    ..and heteroatom analogues, furans, thiophenes, pyrroles, oxazoles, isoxazoles, pyrazoles, pyridines, quinolines, coumarins, indenes, indenones, naphthols, and phenols...
  8. Novel Extended Red-Shifted Rhodamine Dyes
    NICHOLAS CAIRNS; Fiscal Year: 2004
    ..In existing applications of commonly used short and medium wavelength dyes such as coumarins, fluoresceins and rhodamines, assay or tissue components can severely interfere with the fluorescence properties ..
  9. ENDOCRINE DISRUPTING CHEMICALS AND AROMATASE
    Shiuan Chen; Fiscal Year: 2009
    ..The proposed studies will focus on 1014 phytochemicals (including chalcones, chromones, coumarins, flavanones, flavones and isoflavones) that would be purchased from Indofine Co (Somerville, New Jersey)...
  10. ENDOCRINE DISRUPTING CHEMICALS AND AROMATASE
    Shiuan Chen; Fiscal Year: 2007
    ..The proposed studies will focus on 1014 phytochemicals (including chalcones, chromones, coumarins, flavanones, flavones and isoflavones) that would be purchased from Indofine Co (Somerville, New Jersey)...
  11. Antioxidants and oxidative damage in mitochondria
    Cecilia Giulivi; Fiscal Year: 2004
    ..The antioxidant effect of flavonoids, coumarins, and catechins will be studied in terms of hydroxyl substitution, conjugation of rings, and o-methylation of ..
  12. Antioxidants and oxidative damage in mitochondria
    Cecilia Giulivi; Fiscal Year: 2002
    ..The antioxidant effect of flavonoids, coumarins, and catechins will be studied in terms hydroxyl substitution, conjugation of rings, and o- methylation of ..
  13. Cytochrome P450 in Nicotine Metabolism
    Sharon E Murphy; Fiscal Year: 2010
    ..Also of key importance, is that the inactivation of P450 2A enzymes will impact the metabolism of the tobacco specific carcinogens, NNK and NNN. ..
  14. Cytochrome P450 in Nicotine Metabolism
    Sharon Murphy; Fiscal Year: 2004
    ....
  15. Cytochrome P450 in Nicotine Metabolism
    Sharon Murphy; Fiscal Year: 2007
    ..Also of key importance, is that the inactivation of P450 2A enzymes will impact the metabolism of the tobacco specific carcinogens, NNK and NNN. ..
  16. MOLECULAR MECHANISM OF PHOTORECEPTOR G PROTEIN SIGNALING
    Nikolai Artemyev; Fiscal Year: 2007
    ..Overall, these studies will help to achieve a better understanding of Gt signaling mechanisms as well as other G protein signaling systems and will provide information relevant to retinal diseases. ..
  17. Zinc Fluorescence Biosensing and Imaging Technology
    Richard Thompson; Fiscal Year: 2007
    ..If successful, we anticipate that our technology will be of use in understanding and developing treatments for the conditions listed above. ..
  18. INHIBITION OF TRYPANOSOMAL AND LEISHMANIAL GLYCOLYSIS
    Michael Gelb; Fiscal Year: 1999
  19. Molecular Target Focused Discovery of Anticancer Drugs
    GEORGE PETTIT; Fiscal Year: 2005
    ..In summary, the proposed research will be sharply aimed at the discovery and very rapid development of new anticancer drugs for the NCI programs directed at improving human cancer treatments. ..
  20. BIOCHEMISTRY OF PROTEIN PRENYLATION
    Christophe L M J Verlinde; Fiscal Year: 2010
    ..Malaria and African sleeping sickness kill about 2 million and 200,000 people, respectively, each year. New drugs are needed because existing drugs are either ineffective or resistance has developed. ..
  21. Regulation of Retinal cGMP Phosphodiesterases
    Nikolai Artemyev; Fiscal Year: 2009
    ..This research would develop a new level of understanding of structure, function, and regulation of PDE6 necessary to uncover the mechanisms of PDE6 mutations in diseased retina. ..
  22. SYNTHESIS OF PHYLLANTHOSIDE RELATED ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 1991
    ..Once such features are identified, the design of new and possibly more effective antitumor drugs should be feasible...
  23. Design and Synthesis of HIV-1 Protease Inhibitors
    AMOS SMITH; Fiscal Year: 2004
    ....
  24. SYNTHESIS OF SPONGISTATIN ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 2007
    ..abstract_text> ..
  25. ANTICANCER AGENTS--STRUCTURE AND SYNTHESIS
    AMOS SMITH; Fiscal Year: 2004
    ..The design of new and possibly more effective agents should then be feasible. ..
  26. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
    ..The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease. ..
  27. Pilot-Scale Libraries for High-throughput Screening
    AMOS SMITH; Fiscal Year: 2007
    ....