Summary: A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin.

Top Publications

  1. ncbi Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice
    Masuko Kobori
    National Food Research Institute, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan
    Mol Nutr Food Res 55:530-40. 2011
  2. ncbi Dietary antioxidant supplementation combined with quercetin improves cycling time trial performance
    Holden S H Macrae
    Dept of Sports Medicine, Pepperdine University, Malibu, CA 90263, USA
    Int J Sport Nutr Exerc Metab 16:405-19. 2006
  3. ncbi Dietary quercetin supplementation is not ergogenic in untrained men
    Kirk J Cureton
    Department of Kinesiology, Ramsey Center, 330 River Road, Univ of Georgia Athens, GA 30602 6554
    J Appl Physiol (1985) 107:1095-104. 2009
  4. ncbi Drug combinations with quercetin: doxorubicin plus quercetin in human breast cancer cells
    Davide Staedler
    Centre Hospitalier Universitaire Vaudois CHUV and University of Lausanne UNIL, Lausanne, Switzerland
    Cancer Chemother Pharmacol 68:1161-72. 2011
  5. ncbi In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway
    Monica Comalada
    Department of Pharmacology, University of Granada, Granada, Spain
    Eur J Immunol 35:584-92. 2005
  6. ncbi Health effects of quercetin: from antioxidant to nutraceutical
    Agnes W Boots
    Department of Pharmacology and Toxicology, Faculty of Medicine Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Eur J Pharmacol 585:325-37. 2008
  7. ncbi Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling
    Kui Wang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China
    Autophagy 7:966-78. 2011
  8. ncbi A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties
    M Harwood
    Cantox Health Sciences International, 2233 Argentia Road, Suite 308, Mississauga, Ontario, Canada L5N 2X7
    Food Chem Toxicol 45:2179-205. 2007
  9. ncbi Quercetin, a flavonoid antioxidant, prevents and protects against ethanol-induced oxidative stress in mouse liver
    María Francisca Molina
    Department of Pharmacology, Faculty of Pharmacy, UCM, Madrid, Spain
    Biol Pharm Bull 26:1398-402. 2003
  10. ncbi Effect of quercetin supplementation on maximal oxygen uptake in men and women
    Matthew S Ganio
    Human Performance Laboratory, University of Connecticut, Storrs, CT, USA
    J Sports Sci 28:201-8. 2010

Detail Information

Publications395 found, 100 shown here

  1. ncbi Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice
    Masuko Kobori
    National Food Research Institute, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan
    Mol Nutr Food Res 55:530-40. 2011
    To determine the effect of consumption of a quercetin-rich diet on obesity and dysregulated hepatic gene expression.
  2. ncbi Dietary antioxidant supplementation combined with quercetin improves cycling time trial performance
    Holden S H Macrae
    Dept of Sports Medicine, Pepperdine University, Malibu, CA 90263, USA
    Int J Sport Nutr Exerc Metab 16:405-19. 2006
    ..double-blind, cross-over study to test the effects of twice daily AS containing essential vitamins plus quercetin (FRS), and AS minus quercetin (FRS-Q) versus a baseline TT (B)...
  3. ncbi Dietary quercetin supplementation is not ergogenic in untrained men
    Kirk J Cureton
    Department of Kinesiology, Ramsey Center, 330 River Road, Univ of Georgia Athens, GA 30602 6554
    J Appl Physiol (1985) 107:1095-104. 2009
    b>Quercetin supplementation increases muscle oxidative capacity and endurance in mice, but its ergogenic effect in humans has not been established...
  4. ncbi Drug combinations with quercetin: doxorubicin plus quercetin in human breast cancer cells
    Davide Staedler
    Centre Hospitalier Universitaire Vaudois CHUV and University of Lausanne UNIL, Lausanne, Switzerland
    Cancer Chemother Pharmacol 68:1161-72. 2011
    ..In this work, we evaluated whether the plant-derived flavonoid quercetin may represent such an agent.
  5. ncbi In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway
    Monica Comalada
    Department of Pharmacology, University of Granada, Granada, Spain
    Eur J Immunol 35:584-92. 2005
    b>Quercetin is a common antioxidant flavonoid found in vegetables, which is usually present in glycosylated forms, such as quercitrin (3-rhamnosylquercetin)...
  6. ncbi Health effects of quercetin: from antioxidant to nutraceutical
    Agnes W Boots
    Department of Pharmacology and Toxicology, Faculty of Medicine Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Eur J Pharmacol 585:325-37. 2008
    b>Quercetin, a member of the flavonoids family, is one of the most prominent dietary antioxidants...
  7. ncbi Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling
    Kui Wang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China
    Autophagy 7:966-78. 2011
    b>Quercetin, a dietary antioxidant present in fruits and vegetables, is a promising cancer chemopreventive agent that inhibits tumor promotion by inducing cell cycle arrest and promoting apoptotic cell death...
  8. ncbi A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties
    M Harwood
    Cantox Health Sciences International, 2233 Argentia Road, Suite 308, Mississauga, Ontario, Canada L5N 2X7
    Food Chem Toxicol 45:2179-205. 2007
    b>Quercetin is a naturally-occurring flavonol (a member of the flavonoid family of compounds) that has a long history of consumption as part of the normal human diet...
  9. ncbi Quercetin, a flavonoid antioxidant, prevents and protects against ethanol-induced oxidative stress in mouse liver
    María Francisca Molina
    Department of Pharmacology, Faculty of Pharmacy, UCM, Madrid, Spain
    Biol Pharm Bull 26:1398-402. 2003
    This study evaluates whether quercetin (25, 50 and 75 mg/kg body weight) treatment has a protective effect on the pro-oxidant-antioxidant state following chronic ethanol treatment in mice...
  10. ncbi Effect of quercetin supplementation on maximal oxygen uptake in men and women
    Matthew S Ganio
    Human Performance Laboratory, University of Connecticut, Storrs, CT, USA
    J Sports Sci 28:201-8. 2010
    b>Quercetin is a naturally occurring flavonoid with anti-oxidant and anti-inflammatory properties. The effect of quercetin supplementation on maximal oxygen uptake (VO(2max)) is unknown...
  11. ncbi Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats
    Leonor Rivera
    Department of Pharmacology, CIBER EHD, School of Pharmacy, University of Granada, Granada, Spain
    Obesity (Silver Spring) 16:2081-7. 2008
    The aim of this study was to analyze the effects of chronic administration of high doses of quercetin on metabolic syndrome abnormalities, including obesity, dyslipidemia, hypertension, and insulin resistance...
  12. ncbi Quercetin exerts a neuroprotective effect through inhibition of the iNOS/NO system and pro-inflammation gene expression in PC12 cells and in zebrafish
    Zai Jun Zhang
    Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao SAR, PR China
    Int J Mol Med 27:195-203. 2011
    ..b>Quercetin, a major flavonoid naturally occurring in plants, deserves attention because of its beneficial effects observed ..
  13. pmc The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice
    Xiaoguang Cao
    Immunopathology Section, Laboratory of Immunology National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    Exp Eye Res 91:15-25. 2010
    b>Quercetin, a member of the flavonoid family, is one of the most prominent dietary antioxidants...
  14. ncbi Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man
    P C Hollman
    DLO State Institute for Quality Control of Agricultural Products RIKILT DLO, Wageningen, The Netherlands
    FEBS Lett 418:152-6. 1997
    b>Quercetin is a strong antioxidant and a major dietary flavonoid. Epidemiological studies suggest that consumption of quercetin protects against cardiovascular disease, but its absorption in man is controversial...
  15. ncbi The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells
    Victoria García-Mediavilla
    Institute of Biomedicine, University of Leon, 24071 Leon, Spain
    Eur J Pharmacol 557:221-9. 2007
    We examined the ability of the flavonoids quercetin and kaempferol to modulate inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and reactive C-protein (CRP) expression, and to induce changes in the nuclear factor kappa B (..
  16. ncbi Quercetin and endurance exercise capacity: a systematic review and meta-analysis
    Jochen Kressler
    School of Applied Physiology, Georgia Institute of Technology, Atlanta, GA 30332 0356, USA
    Med Sci Sports Exerc 43:2396-404. 2011
    b>Quercetin is a dietary flavonoid purported to improve human endurance exercise capacity. However, published findings are mixed.
  17. pmc Quercetin increases cystic fibrosis transmembrane conductance regulator-mediated chloride transport and ciliary beat frequency: therapeutic implications for chronic rhinosinusitis
    Shaoyan Zhang
    Gregory Fleming James Cystic Fibrosis Research Center, Birmingham, Alabama, USA
    Am J Rhinol Allergy 25:307-12. 2011
    ..Several naturally occurring flavonoid compounds, including quercetin, have shown the capacity to increase transepithelial Cl(-) transport...
  18. ncbi The flavonoid quercetin in disease prevention and therapy: facts and fancies
    Maria Russo
    Institute of Food Sciences, National Research Council, Avellino, Italy
    Biochem Pharmacol 83:6-15. 2012
    ..b>Quercetin falls into this category and possesses a broad range of biological properties...
  19. ncbi Dietary polyphenols in cancer prevention: the example of the flavonoid quercetin in leukemia
    Carmela Spagnuolo
    Istituto di Scienze dell Alimentazione, Consiglio Nazionale delle Ricerche, Avellino, Italy
    Ann N Y Acad Sci 1259:95-103. 2012
    ..We recently demonstrated that the flavonoid quercetin, naturally present in the diet and belonging to the class of phytochemicals, is able to sensitize several ..
  20. ncbi The protective effect of quercetin against oxidative stress in the human RPE in vitro
    Daniel Kook
    Department of Ophthalmology, Ludwig Maximilians Universitat, Munich, Germany
    Invest Ophthalmol Vis Sci 49:1712-20. 2008
    To investigate the possible protective effect of the dietary antioxidant quercetin on retinal pigment epithelial (RPE) cell dysfunction and cellular senescence occurring in age-related macular degeneration (AMD)...
  21. ncbi Potent inhibitory effect of naturally occurring flavonoids quercetin and kaempferol on in vitro osteoclastic bone resorption
    Alice Wattel
    Clinical Pharmacy Laboratory, Universite de Picardie Jules Verne, 1 rue des Louvels, 80000 Amiens, France
    Biochem Pharmacol 65:35-42. 2003
    ..In the present study, we investigated the effects of quercetin and kaempferol, two of the major naturally occurring flavonols on the in vitro bone resorbing activity of ..
  22. ncbi Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles
    Houli Li
    Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan, China
    J Control Release 133:238-44. 2009
    The aim of the present study is to design and characterize quercetin-loaded solid lipid nanoparticles (QT-SLNs), clarify the absorption mechanism of QT-SLNs and to evaluate the potential of using solid lipid nanoparticles (SLNs) as an ..
  23. ncbi Effects of quercetin and EGCG on mitochondrial biogenesis and immunity
    David C Nieman
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Med Sci Sports Exerc 41:1467-75. 2009
    To test the influence of 1000 mg of quercetin (Q) with or without 120 mg of epigallocatechin 3-gallate (EGCG), 400 mg of isoquercetin, and 400 mg of eicosapentaenoic acid and docosahexaenoic acid (Q-EGCG) on exercise performance, muscle ..
  24. ncbi Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-{alpha}-mediated inflammation and insulin resistance in primary human adipocytes
    Chia Chi Chuang
    Department of Nutrition, University of North Carolina Greensboro, Greensboro, NC, USA
    Am J Clin Nutr 92:1511-21. 2010
    b>Quercetin and trans-resveratrol (trans-RSV) are plant polyphenols reported to reduce inflammation or insulin resistance associated with obesity...
  25. ncbi The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-κB inhibition
    R Vidya Priyadarsini
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India
    Eur J Pharmacol 649:84-91. 2010
    ..The dietary phytochemical quercetin, modulates several signal transduction pathways associated with cell proliferation and apoptosis...
  26. ncbi Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance
    J Mark Davis
    University of South Carolina, Department of Exercise Science, Columbia, SC 29208, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1071-7. 2009
    b>Quercetin is one of a broad group of natural polyphenolic flavonoid substances that are being investigated for their widespread health benefits...
  27. ncbi Quercetin suppresses proinflammatory cytokines production through MAP kinases andNF-kappaB pathway in lipopolysaccharide-stimulated macrophage
    Sung Yeon Cho
    Korea Research Institute of Bioscience and Biotechnology, Yusung, Taejon City, South Korea
    Mol Cell Biochem 243:153-60. 2003
    b>Quercetin is a flavonoid molecule ubiquitous in nature and functions as an anti-oxidant and anti-inflammatory agent with little toxicity in vivo and in vitro...
  28. pmc The flavonoid quercetin inhibits proinflammatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-kappa beta system
    Madhavan P Nair
    Department of Medicine and Microbiology, Kaleida Health System, Buffalo General Hospital, State University of New York at Buffalo, Buffalo, NY 14203, USA
    Clin Vaccine Immunol 13:319-28. 2006
    ..We investigated the anti-inflammatory potentials of a safe, common dietary flavonoid component, quercetin, for its ability to modulate the production and gene expression of the proinflammatory cytokine tumor necrosis ..
  29. ncbi Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation
    A I Dorozhko
    All Union Vitamin Research Institute, Moscow
    Biochem Pharmacol 38:1763-9. 1989
    Inhibitory effects of flavonoids rutin and quercetin on ferrous ion-dependent lipid peroxidation of lecithin liposomes and NADPH- and CCl4-dependent lipid peroxidation in rat liver microsomes were studied to elucidate the chelating and ..
  30. ncbi Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas
    Omer Coskun
    Department of Medical Histology and Embryology, Zonguldak Karaelmas University, Faculty of Medicine, Zonguldak, Turkey
    Pharmacol Res 51:117-23. 2005
    The aim of the present study was the evaluation of possible protective effects of quercetin (QE) against beta-cell damage in experimental streptozotocin (STZ)-induced diabetes in rats...
  31. ncbi Anti-asthmatic action of quercetin and rutin in conscious guinea-pigs challenged with aerosolized ovalbumin
    Chan Hun Jung
    Division of Pathophysiology and Pharmacology, College of Pharmacy, Chung Ang University, Seoul 156 756, Korea
    Arch Pharm Res 30:1599-607. 2007
    The effects of quercetin and rutin on the asthmatic responses were studied in ovalbumin (OA)-sensitized conscious guinea pigs challenged with aerosolized-OA...
  32. ncbi Protective effects of quercetin against hydrogen peroxide-induced apoptosis in human neuronal SH-SY5Y cells
    Namiko Suematsu
    Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
    Neurosci Lett 504:223-7. 2011
    ..b>Quercetin, one of the plant flavonoids, has been reported to harbor various physiological properties including antioxidant ..
  33. ncbi Quercetin and sesamin protect neuronal PC12 cells from high-glucose-induced oxidation, nitrosative stress, and apoptosis
    Julie Bournival
    Cellular Neurobiology, Department of Biochemistry, Universite du Quebec a Trois Rivieres, Trois Rivieres, Quebec, Canada
    Rejuvenation Res 15:322-33. 2012
    ..The goal of the present study was to evaluate the effects of the polyphenol quercetin and the lignan sesamin on high-glucose (HG)-induced oxidative damage in an in vitro model of dopaminergic ..
  34. ncbi Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways
    Ping Yao
    Department of General, Visceral, and Transplantation Surgery, Humboldt University, Charite, Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany
    J Hepatol 47:253-61. 2007
    Flavonoids, including quercetin, have been reported to have potent hepatoprotective effects, which may be associated with HO-1 induction...
  35. ncbi Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats
    Sunil K Panchal
    Department of Biological and Physical Sciences, University of Southern Queensland, Toowoomba, Queensland, Australia
    J Nutr 142:1026-32. 2012
    ..We investigated the responses to the flavonol, quercetin, in male Wistar rats (8-9 wk old) divided into 4 groups...
  36. ncbi Protective effects of quercetin against phenylhydrazine-induced vascular dysfunction and oxidative stress in rats
    Saowanee Luangaram
    Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Food Chem Toxicol 45:448-55. 2007
    ..b>Quercetin, one of the potent antioxidant bioflavonoid compounds, has been shown to alleviate oxidative injury by ..
  37. pmc Quercetin protects against diabetes-induced exaggerated vasoconstriction in rats: effect on low grade inflammation
    Mona F Mahmoud
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
    PLoS ONE 8:e63784. 2013
    Vascular complications are the leading cause of morbidity and mortality in patients with diabetes. Quercetin is an important flavonoid with antioxidant and anti-inflammatory activity...
  38. ncbi Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells
    Chi Hoon Park
    Division of Chemistry and Molecular Engineering, Seoul National University, Seoul 151 742, Republic of Korea
    Biochem Biophys Res Commun 328:227-34. 2005
    ..We examined the effect of quercetin, a famous anti-tumor agent, against beta-catenin/Tcf signaling in SW480 cells...
  39. pmc Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory eff
    Mari Hamalainen
    The Immunopharmacology Research Group, University of Tampere, Medical School and Tampere University Hospital, Research Unit, Tampere 33014, Finland
    Mediators Inflamm 2007:45673. 2007
    ..Flavone, the isoflavones daidzein and genistein, the flavonols isorhamnetin, kaempferol and quercetin, the flavanone naringenin, and the anthocyanin pelargonidin inhibited iNOS protein and mRNA expression and also ..
  40. ncbi Isorhamnetin inhibits H₂O₂-induced activation of the intrinsic apoptotic pathway in H9c2 cardiomyocytes through scavenging reactive oxygen species and ERK inactivation
    Bing Sun
    Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, P R China
    J Cell Biochem 113:473-85. 2012
    ..Therefore, isorhamnetin is a promising reagent for the treatment of ROS-induced cardiomyopathy...
  41. pmc Quercetin-mediated Mcl-1 and survivin downregulation restores TRAIL-induced apoptosis in non-Hodgkin's lymphoma B cells
    Guillaume Jacquemin
    INSERM, U866, Dijon, France
    Haematologica 97:38-46. 2012
    ..Unconventional compounds, including polyphenols and the cytokine TRAIL, are being extensively studied for their capacity to restore apoptosis in a large number of tumors, including lymphomas...
  42. ncbi Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase-2 gene expressions by rutin, quercetin, and quercetin pentaacetate in RAW 264.7 macrophages
    Y C Chen
    Graduate Institute of Pharmacognosy Science, Taipei Medical University, Taipei, Taiwan
    J Cell Biochem 82:537-48. 2001
    ..In the present study, we provided evidences to demonstrate that flavonoids rutin, quercetin, and its acetylated product quercetin pentaacetate were able to be used with nitric oxide synthase (NOS) ..
  43. ncbi After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult
    Florencia Arredondo
    Departamento de Neuroquimica, Instituto de Investigaciones Biologicas Clemente Estable, 11600 Montevideo, Uruguay
    Free Radic Biol Med 49:738-47. 2010
    In this work we describe the protective effects of quercetin against H(2)O(2) in 24-h-pretreated neuronal cultures...
  44. pmc Quercetin inhibits IL-1β-induced inflammation, hyaluronan production and adipogenesis in orbital fibroblasts from Graves' orbitopathy
    Jin Sook Yoon
    Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
    PLoS ONE 6:e26261. 2011
    ..We investigated the effect of quercetin in primary cultured orbital fibroblasts from GO, targeting pathways of inflammation, aberrant accumulation of ..
  45. ncbi The pro-apoptotic effect of quercetin in cancer cell lines requires ERβ-dependent signals
    Pamela Bulzomi
    Department of Biology, University Roma Tre, Roma, Italy
    J Cell Physiol 227:1891-8. 2012
    b>Quercetin has potentially beneficial effects on disease prevention, including cancer. An intriguing issue regarding the mechanisms of action of quercetin is the ability of this drug to modulate estrogen receptor (ER) activities...
  46. ncbi Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells
    Ju Wan Kang
    Department of Otorhinolaryngology, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemoon Gu, Seoul, Republic of Korea
    Phytother Res 24:S77-82. 2010
    ..The results of cell proliferation assays on oral cavity cancer cells showed that kaempferol and quercetin significantly inhibited cellular proliferation at a concentration of 40 microM...
  47. ncbi Quercetin does not affect rating of perceived exertion in athletes during the Western States endurance run
    Alan C Utter
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, North Carolina 28608, USA
    Res Sports Med 17:71-83. 2009
    The purpose of this study was to measure the influence of quercetin supplementation on ratings of perceived exertion in ultramarathon runners competing in the 160-km Western States Endurance Run (WSER)...
  48. ncbi Effects of hyperin, isoquercitrin and quercetin on lipopolysaccharide-induced nitrite production in rat peritoneal macrophages
    Sanghyun Lee
    Department of Applied Plant Science, Chung Ang University, Anseong 456 756, Korea
    Phytother Res 22:1552-6. 2008
    ..To analyse the action mechanism of this extract, the effect of hyperin (quercetin-3-O-beta-d-galactose) isolated from the ethyl acetate fraction of the root of A...
  49. ncbi Quercetin reduces susceptibility to influenza infection following stressful exercise
    J M Davis
    University of South Carolina, Department of Exercise Science, PHRC 301, 921 Assembly St, Columbia, SC 29208, USA
    Am J Physiol Regul Integr Comp Physiol 295:R505-9. 2008
    ..We have shown that exercise stress can increase susceptibility to infection. Quercetin, a flavonoid present in a wide variety of fruits and vegetables, has been reported to inhibit infectivity and ..
  50. ncbi Role of quercetin and its in vivo metabolites in protecting H9c2 cells against oxidative stress
    C Angeloni
    Department of Biochemistry G Moruzzi, Nutrition Research Centre, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Biochimie 89:73-82. 2007
    The aim of this study was to investigate the potential of quercetin and two of its "in vivo" metabolites, 3'-O-methyl quercetin and 4'-O-methyl quercetin, to protect H9c2 cardiomyoblasts against H(2)O(2)-induced oxidative ..
  51. ncbi The role of ASIC1a in neuroprotection elicited by quercetin in focal cerebral ischemia
    Anand Kumar Pandey
    Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, Brig SK Mazumdar Road, Delhi 110054, India
    Brain Res 1383:289-99. 2011
    ..ASIC1a was found to be inhibited by some flavonoids which carry an anti-inflammatory property particularly quercetin, which could be exploited in hypoxic conditions like cerebral ischemia...
  52. ncbi The dietary flavonoid quercetin increases VO(2max) and endurance capacity
    J Mark Davis
    Div of Applied Physiology, Dept of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    Int J Sport Nutr Exerc Metab 20:56-62. 2010
    b>Quercetin, a natural polyphenolic flavonoid substance present in a variety of food plants, has been shown in vitro and in animal studies to have widespread health and performance benefits resulting from a combination of biological ..
  53. ncbi Comparative evaluation of quercetin, isoquercetin and rutin as inhibitors of alpha-glucosidase
    Yan qin Li
    Key Laboratory of Chemical Biology and Molecular Engineering of the Ministry of Education, Shanxi University, Taiyuan, 030006, China
    J Agric Food Chem 57:11463-8. 2009
    Three flavonoids from tartary buckwheat bran, namely, quercetin (Que), isoquercetin (Iso) and rutin (Rut), have been evaluated as alpha-glucosidase inhibitors by fluorescence spectroscopy and enzymatic kinetics and have also been ..
  54. ncbi Effects of six weeks of quercetin supplementation on physical performance in ROTC cadets
    Kevin A Bigelman
    Metabolism and Body Composition Laboratory, Department of Kinesiology, Ramsey Center, Rm 109, 300 River Street, University of Georgia, Athens, GA 30602, USA
    Mil Med 175:791-8. 2010
    To investigate the effects of 6 weeks of quercetin supplementation on physical performance during military physical training.
  55. ncbi Acceleration of fibril formation and thermal stabilization of collagen fibrils in the presence of taxifolin (dihydroquercetin)
    Y S Tarahovsky
    Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino
    Bull Exp Biol Med 144:791-4. 2007
    ..Taxifolin capacity to stimulate fibril formation and promote stabilization of fibrillar forms of collagen can be used in medicine...
  56. ncbi Suppression of hepatitis C virus by the flavonoid quercetin is mediated by inhibition of NS3 protease activity
    L Bachmetov
    Molecular Hepatology Research Laboratory, Felsenstein Medical Research Center, Sackler School of Medicine, Tel Aviv University, Petah Tikva, Israel
    J Viral Hepat 19:e81-8. 2012
    ..A potent inhibitory effect of NS3 catalytic activity was obtained with Embelia ribes plant extracts. Quercetin, a ubiquitous plant flavonoid, was identified as the active substance in the fractioned extract...
  57. ncbi Role of quercetin in modulating rat cardiomyocyte gene expression profile
    C Angeloni
    Department of Biochemistry, G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Am J Physiol Heart Circ Physiol 294:H1233-43. 2008
    ..b>Quercetin, a major flavonoid present in the human diet, has been widely studied, and its biological properties are ..
  58. ncbi Flavonoid permeability across an in situ model of the blood-brain barrier
    Kuresh A Youdim
    Antioxidant Research Group, Wolfson Centre for Age Related Diseases, Centre for Neuroscience Research, Guy s King s and St Thomas s School of Biomedical Sciences, King s College, London SE1 1UL, UK
    Free Radic Biol Med 36:592-604. 2004
    ..This study examined naringenin and quercetin permeability across the blood-brain barrier (BBB), using in vitro (ECV304/C6 coculture) and in situ (rat) models...
  59. pmc Quercetin suppresses cyclooxygenase-2 expression and angiogenesis through inactivation of P300 signaling
    Xiangsheng Xiao
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, China
    PLoS ONE 6:e22934. 2011
    b>Quercetin, a polyphenolic bioflavonoid, possesses multiple pharmacological actions including anti-inflammatory and antitumor properties. However, the precise action mechanisms of quercetin remain unclear...
  60. ncbi Chronic quercetin ingestion and exercise-induced oxidative damage and inflammation
    Steven R McAnulty
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Appl Physiol Nutr Metab 33:254-62. 2008
    b>Quercetin is a flavonoid compound that has been demonstrated to be a potent antioxidant in vitro...
  61. ncbi The acute effect of ingesting a quercetin-based supplement on exercise-induced inflammation and immune changes in runners
    Manuela Konrad
    Center for Molecular Medicine, Graz Medical University, Graz, Austria
    Int J Sport Nutr Exerc Metab 21:338-46. 2011
    This study tested the acute anti-inflammatory and immune-modulating influence of a quercetin-based supplement consumed by endurance athletes 15 min before an intense 2-hr run...
  62. ncbi Antiviral activity of quercetin 7-rhamnoside against porcine epidemic diarrhea virus
    Hwa Jung Choi
    Natural Medicines Research Centre, Korea Research Institute of Bioscience and Biotechnology, Taejon 305 333, Republic of Korea
    Antiviral Res 81:77-81. 2009
    ..Several structural analogues of Q7R, quercetin, apigenin, luteolin and catechin, also showed moderate anti-PEDV activity...
  63. ncbi Inhibition of lung cancer cell growth by quercetin glucuronides via G2/M arrest and induction of apoptosis
    Jen Hung Yang
    Department of Dermatology, Chung Shan Medical University Hospital, Taichung, Taiwan, Republic of China
    Drug Metab Dispos 34:296-304. 2006
    Lung cancer is the leading cause of cancer death in many developed countries, including Taiwan. Quercetin, a widely distributed bioflavonoid, is well known to induce growth inhibition in a variety of human cancer cells...
  64. ncbi Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study
    Sarah Egert
    Institute of Human Nutrition and Food Science, Department of Human Nutrition, Christian Albrechts University Kiel, Germany
    Br J Nutr 102:1065-74. 2009
    ..However, the effects of individual flavonoids, for example, quercetin, remain unclear...
  65. ncbi Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat
    Mokhtar I Yousef
    Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt
    Food Chem Toxicol 48:3246-61. 2010
    The present study was carried out to evaluate the potential protective role of quercetin and curcumin against paracetamol-induced oxidative injury, liver damage and impairment of kidney function, as well as haematotoxicity in rats...
  66. ncbi The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
    Jiyun Ahn
    Food Function Research Center, Korea Food Research Institute, 516, Baekhyun dong, Bundang gu, Seongnam si, Gyeonggi do 463 746, Republic of Korea
    Biochem Biophys Res Commun 373:545-9. 2008
    b>Quercetin is the most abundant flavonoid and is assumed to have protective roles against the pathogenesis of multiple diseases associated with oxidative stress...
  67. ncbi Quercetin decreases oxidative stress, NF-kappaB activation, and iNOS overexpression in liver of streptozotocin-induced diabetic rats
    Alexandre Simões Dias
    Universidade Federal de Rio Grande do Sul, Porto Alegre, RS, Brasil
    J Nutr 135:2299-304. 2005
    ..This study investigated the protective effects of quercetin treatment on oxidative stress, nuclear factor (NF)-kappaB activation and expression of inducible nitric oxide ..
  68. ncbi Tissue distribution of quercetin in rats and pigs
    Vincent C J de Boer
    RIKILT Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
    J Nutr 135:1718-25. 2005
    b>Quercetin is a dietary polyphenolic compound with potentially beneficial effects on health. Claims that quercetin has biological effects are based mainly on in vitro studies with quercetin aglycone...
  69. ncbi Liposomal quercetin efficiently suppresses growth of solid tumors in murine models
    Zhi Ping Yuan
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, People s Republic of China
    Clin Cancer Res 12:3193-9. 2006
    b>Quercetin is a potent chemotherapeutic drug. Clinical trials exploring different schedules of administration of quercetin have been hampered by its extreme water insolubility...
  70. ncbi Protective effects of resveratrol and quercetin against MPP+ -induced oxidative stress act by modulating markers of apoptotic death in dopaminergic neurons
    Julie Bournival
    Department of Biochemistry and Neuroscience Research Group, Universite du Quebec a Trois Rivieres, Trois Rivieres, QC, G9A 5H7, Canada
    Cell Mol Neurobiol 29:1169-80. 2009
    ..Resveratrol, a red wine extract, and quercetin, found mainly in green tea, are two natural polyphenols, presenting antioxidant properties in a variety of ..
  71. ncbi Quercetin's influence on exercise performance and muscle mitochondrial biogenesis
    David C Nieman
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Med Sci Sports Exerc 42:338-45. 2010
    To determine the influence of 2 wk of quercetin (Q; 1000 mg x d(-1)) compared with placebo (P) supplementation on exercise performance and skeletal muscle mitochondrial biogenesis in untrained, young adult males (N = 26, age = 20.2 +/- 0...
  72. ncbi Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans
    Sarah Egert
    Institute of Human Nutrition and Food Science and 4Institute of Animal Nutrition, Physiology and Metabolism, Christian Albrechts University Kiel, 24105 Kiel, Germany
    J Nutr 138:1615-21. 2008
    Our aim was to investigate the effects of an oral supplementation of quercetin at 3 different doses on plasma concentrations of quercetin, parameters of oxidant/antioxidant status, inflammation, and metabolism...
  73. pmc Protective effect of quercetin in primary neurons against Abeta(1-42): relevance to Alzheimer's disease
    Mubeen Ahmad Ansari
    Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA
    J Nutr Biochem 20:269-75. 2009
    b>Quercetin, a flavonoid found in various foodstuffs, has antioxidant properties and increases glutathione (GSH) levels and antioxidant enzyme function...
  74. ncbi Chemoresistance of lung cancer stemlike cells depends on activation of Hsp27
    Han Shui Hsu
    Institute of Emergency and Critical Care Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan
    Cancer 117:1516-28. 2011
    ..In the current study, the authors sought to identify the molecular mechanisms underlying the chemoresistance of lung cancer stem or initiation cells (cancer stem cells)...
  75. ncbi Quercetin reduces blood pressure in hypertensive subjects
    Randi L Edwards
    Division of Nutrition, University of Utah, Salt Lake City, UT 84112, USA
    J Nutr 137:2405-11. 2007
    Epidemiological studies report that quercetin, an antioxidant flavonol found in apples, berries, and onions, is associated with reduced risk of coronary heart disease and stroke...
  76. ncbi Quercetin allievates oxidative stress in streptozotocin-induced diabetic rats
    T Mahesh
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, India
    Phytother Res 18:123-7. 2004
    ..b>Quercetin, a constituent present in fruits and vegetables, was studied in two different doses (50 and 80 mg/kg body weight)..
  77. ncbi Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3)
    M R Vijayababu
    Department of Endocrinology, Dr ALM Postgraduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600 113, India
    Mol Cell Biochem 287:109-16. 2006
    ..b>Quercetin is a flavonoid and widely used as an antioxidant and recent studies have revealed its pleiotropic anticancer and ..
  78. ncbi Antihypertensive effects of the flavonoid quercetin
    Francisco Perez-Vizcaino
    Department of Pharmacology, School of Medicine, University Complutense of Madrid, Madrid and Ciber Enfermedades Respiratorias Ciberes, Spain
    Pharmacol Rep 61:67-75. 2009
    ..The present review addresses the antihypertensive effect of quercetin, one of the most abundant flavonoids present in fruits and vegetables, and probably the best studied flavonoid ..
  79. pmc Relative antioxidant activities of quercetin and its structurally related substances and their effects on NF-κB/CRE/AP-1 signaling in murine macrophages
    Byung Hak Kim
    Department of Pharmacology, Seoul National University College of Medicine, Seoul, 110 799, Korea
    Mol Cells 35:410-20. 2013
    ..b>Quercetin is flavonoid that occurs naturally in plants and is widely used as a nutritional supplement due to its ..
  80. ncbi Bioavailability of quercetin: problems and promises
    X Cai
    Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan 250012, China
    Curr Med Chem 20:2572-82. 2013
    b>Quercetin (QC) is a typical plant flavonoid, possesses diverse pharmacologic effects including antiinflammatory, antioxidant, anti-cancer, anti-anaphylaxis effects and against aging...
  81. ncbi Underlying mechanism of quercetin-induced cell death in human glioma cells
    Eui Joong Kim
    Department of Neurosurgery, College of Medicine, Pusan National University, Pusan 602 739, South Korea
    Neurochem Res 33:971-9. 2008
    There has been considerable interest in recent years in the anti-tumor activities of flavonoids. Quercetin, a ubiquitous bioactive flavonoid, can inhibit proliferation and induce apoptosis in a variety of cancer cells...
  82. ncbi Genotoxicity and apoptosis in Drosophila melanogaster exposed to benzene, toluene and xylene: attenuation by quercetin and curcumin
    Mahendra P Singh
    Embryotoxicology Section, Indian Institute of Toxicology Research CSIR, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India
    Toxicol Appl Pharmacol 253:14-30. 2011
    ..apoptotic potential of these compounds and subsequently evaluated the efficiency of two phytochemicals, namely, quercetin and curcumin in attenuating test chemical induced toxicity...
  83. ncbi Quercetin's effect on cycling efficiency and substrate utilization
    Charles L Dumke
    Department of Health and Human Perfomance, University of Montana, Missoula, MT 59812, USA
    Appl Physiol Nutr Metab 34:993-1000. 2009
    Previous evidence suggests that quercetin supplementation increases performance in humans...
  84. ncbi Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-gamma by flavonoids in mouse macrophages
    Y C Liang
    Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei
    FEBS Lett 496:12-8. 2001
    ..These results suggested that these three flavonoids might act as allosteric effectors and were able to bind to PPAR gamma and activate it, but its binding site might be different from the natural ligand BRL49653...
  85. ncbi Quercetin offers cardioprotection against progression of experimental autoimmune myocarditis by suppression of oxidative and endoplasmic reticulum stress via endothelin-1/MAPK signalling
    Somasundaram Arumugam
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Free Radic Res 46:154-63. 2012
    In order to test the hypothesis that treatment with quercetin at a dose of 10 mg/kg protects from the progression of experimental autoimmune myocarditis (EAM) to dilated cardiomyopathy (DCM), we have used the rat model of EAM induced by ..
  86. pmc Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms
    Vikas Dudeja
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Gastroenterology 136:1772-82. 2009
    ..We aimed to elucidate the mechanism by which HSP70 inhibits apoptosis in cancer cells...
  87. ncbi Differential protective effects of quercetin, resveratrol, rutin and epigallocatechin gallate against mitochondrial dysfunction induced by indomethacin in Caco-2 cells
    Catalina Carrasco-Pozo
    Laboratory of Microbiology and Probiotics, Institute of Nutrition and Food Technology, University of Chile, Av Macul 5540, Santiago, P O Box 138 11, Chile
    Chem Biol Interact 195:199-205. 2012
    ..The aim of this study was to evaluate the protective effects of dietary polyphenols quercetin, rutin, resveratrol and epigallocatechin gallate against the alterations of mitochondrial function induced by ..
  88. ncbi Anti-inflammatory, antiviral and quantitative study of quercetin-3-O-β-D-glucuronide in Polygonum perfoliatum L
    Dongsheng Fan
    The Research Center for Quality Control of Natural Medicine, Guizhou Normal University, Guiyang 550001, China
    Fitoterapia 82:805-10. 2011
    b>Quercetin-3-O-β-D-glucuronide, isolated from Polygonum perfoliatum L., was evaluated by antiviral efficacy against influenza A virus and anti-inflammatory activity in vivo in mouse, and it was used for quality evaluation of P...
  89. ncbi Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars
    Toan Thang Phan
    Department of Plastic Surgery, Singapore General Hospital
    J Trauma 57:1032-7. 2004
    Keloids are characterized by abnormal proliferation and overproduction of extracellular matrix. Quercetin, a dietary compound, has strong antioxidant and anticancer properties...
  90. ncbi Protective effect of quercetin against paraquat-induced lung injury in rats
    Hee K Park
    College of Pharmacy, Seoul National University, Seoul, Republic of Korea
    Life Sci 87:181-6. 2010
    Paraquat (PQ) is known to induce pulmonary injury via a redox cyclic reaction. The present study was aimed to determine the protective effects of quercetin against PQ-induced pulmonary injury in association with its antioxidant activity.
  91. ncbi Quercetin significantly decreased cyclosporin oral bioavailability in pigs and rats
    Su Lan Hsiu
    Department of Pharmacy, China Medical College, Taichung, 404 Taiwan, ROC
    Life Sci 72:227-35. 2002
    ..b>Quercetin is an inhibitor of CYP3A4 and a modulator of Pgp...
  92. ncbi Quercetin-mediated longevity in Caenorhabditis elegans: is DAF-16 involved?
    Nadine Saul
    Humboldt Universitat zu Berlin, Department of Biology, Arboretum, Spaethstr 80 81, 12437 Berlin, Germany
    Mech Ageing Dev 129:611-3. 2008
    The polyphenol quercetin has recently been found to extend lifespan and increase stress resistance in the nematode Caenorhabditis elegans. The forkhead transcription factor DAF-16 has previously been linked to these effects...
  93. pmc Hsp27 participates in the maintenance of breast cancer stem cells through regulation of epithelial-mesenchymal transition and nuclear factor-κB
    Li Wei
    Department of Neurosurgery, Taipei Medical University Shuang Ho Hospital, Jhongjheng Rd, No 291, New Taipei City, 23561, Taiwan
    Breast Cancer Res 13:R101. 2011
    ..However, the involvement of Hsp27 in the maintenance of BCSC is largely unknown...
  94. ncbi Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts
    Faiy H Psahoulia
    Laboratory of Signal Mediated Gene Expression, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48 Vasileos Konstantinou Avenue, Athens 11635, Greece
    Mol Cancer Ther 6:2591-9. 2007
    ..This results in the need for combination therapy. In this study, we have investigated whether the flavonoid quercetin could sensitize human colon adenocarcinoma cell lines to TRAIL-induced apoptosis...
  95. ncbi Dietary administration of high doses of pterostilbene and quercetin to mice is not toxic
    M J Ruiz
    Departamento de Fisiologia, Facultat de Farmacia, Universitat de Valencia, Valencia, Spain
    J Agric Food Chem 57:3180-6. 2009
    The aim of this study is to evaluate possible harmful effects of high doses of t-pterostilbene (t-PTER) and quercetin (QUER) in Swiss mice...
  96. ncbi Isoquercitrin is the most effective antioxidant in the plant Thuja orientalis and able to counteract oxidative-induced damage to a transformed cell line (RGC-5 cells)
    Sang Hoon Jung
    Nuffield Laboratory of Ophthalmology, Oxford University, John Radcliffe Hospital, Oxford, UK
    Neurochem Int 57:713-21. 2010
  97. ncbi Quercetin: potentials in the prevention and therapy of disease
    Stephan C Bischoff
    Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
    Curr Opin Clin Nutr Metab Care 11:733-40. 2008
    b>Quercetin is discussed since several decades as a multipotent bioflavonoid with great potential for the prevention and treatment of disease...
  98. ncbi Quercetin protects against oxidative stress associated damages in a rat model of transient focal cerebral ischemia and reperfusion
    Ajmal Ahmad
    Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi, 110062, India
    Neurochem Res 36:1360-71. 2011
    ..The purpose of this study was to determine whether the quercetin dihydrate (Q) protects against cerebral ischemia neuronal damage...
  99. ncbi Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats
    Akari Ishisaka
    Department of Food Science, Graduate School of Nutrition and Biosciences, University of Tokushima, Tokushima, Japan
    Free Radic Biol Med 51:1329-36. 2011
    b>Quercetin is widely distributed in vegetables and herbs and has been suggested to act as a neuroprotective agent. Here, we demonstrate that quercetin can accumulate enough to exert biological activity in rat brain tissues...
  100. ncbi Dietary polyphenol quercetin targets pancreatic cancer stem cells
    Wei Zhou
    Molecular OncoSurgery, University Hospital Heidelberg and German Cancer Research Center Heidelberg, Heidelberg, Germany
    Int J Oncol 37:551-61. 2010
    ..Since recent data suggest targeting of cancer stem cells by some dietary agents we studied the effect of quercetin, a major polyphenol and flavonoid commonly detected in many fruits and vegetables...
  101. ncbi Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement
    Qing Hua Hu
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China
    Am J Physiol Renal Physiol 297:F1080-91. 2009
    ..Lowering serum uric acid levels with allopurinol, rutin, and quercetin increased the urinary uric acid/creatinine ratio and FE(ur) and attenuated other fructose-induced metabolic ..

Research Grants63

  1. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2013
    ..mice, CRHR-1;CRHR-2 -/- and UCP2 -/- mice, (3) Inhibitory effect of a flavonoid formulation containing luteolin/quercetin/olive kernel oil on endurance and brain biomarkers...
  2. Heat Shock Protein Synthesis Inhibitor Treatment of Hepatitis C Viral Infection
    SAMUEL WHEELER FRENCH; Fiscal Year: 2013
    ..Treatment with the heat shock protein synthesis inhibitors Quercetin and KNK437 reduced infectious particle production at non-toxic concentrations...
  3. Combined use of green tea and quercetin in prostate cancer
    ..Catechol-compounds such as EGCG and quercetin, a natural flavonoid occurring in many fruits and vegetable, inhibit COMT activity in prostate cancer cells (..
  4. Identification of small molecule inhibitors of protein disulfide isomerase
    ROBERT C FLAUMENHAFT; Fiscal Year: 2012
    ..9%. Twenty new PDI inhibitors were identified during this pilot screen. Among them was the quercetin flavonol, rutin...
  5. Phase 1 Study of Quercetin for the Treatment of Fanconi Anemia
    Parinda Mehta; Fiscal Year: 2013
    ..It is our central hypothesis that treatment with the ROS scavenger quercetin will be safe, well tolerated and will modulate ROS levels in children with FA, which in turn will ameliorate or ..
  6. Quercetin to enhance the bioavailability and activity of green tea polyphenols
    ..The objective of the proposed human intervention study remains to determine whether a combined administration of quercetin and green tea (GT) will increase the bioavailability and decrease the metabolism of GT polyphenols (GTPs) such ..
  7. Regulation of Macrophages in Obesity-Enhanced Colon Cancer:Benefits of Quercetin
    ELIZABETH ANGELA MURPHY; Fiscal Year: 2013
    ..on the regulation of macrophage behavior in a mouse model of obesity-enhanced CRC, and further, whether dietary quercetin can target this process...
  8. Hypoxia-inducible Transcription Factor 1 (HIF-1) in Vascular Aging
    Farzaneh A Sorond; Fiscal Year: 2010
    ..two HIF-1 activators available for use in humans-the iron chelator Desferrioxamine (DFO) and a dietary flavonol, quercetin, which can be used to test the effects of acute and chronic HIF-1 activation on the vascular aging process...
  9. Curcumin and Quercetin in Colon Cancer: Role of Macrophage-Induced Inflammation
    ELIZABETH ANGELA MURPHY; Fiscal Year: 2010
    ..of the anti- inflammatory dietary constituents curcumin, which is a component of the Indian spice currie, and quercetin, a flavonoid present in various fruits and vegetables, have been associated with reduced CRC risk...
  10. Mechanisms of Reduced Heart Failure Pathogenesis with Phytochemical Intake
    Steven F Bolling; Fiscal Year: 2012
    ..Grape phytochemicals of broad interest include anthocyanins, flavanols (catechin, epicatechin, quercetin), and stilbenes (resveratrol)...
  11. Molecular Determinants for the Bioactivity of the Flavonoid Quercetin
    Temesgen Samuel; Fiscal Year: 2010
    ..b>Quercetin is a naturally occurring bioactive flavonoid ubiquitously available in fruits, vegetables and other plants...
  12. Lung Cancer Prevention by Quercetin Through IL-6 Secretion &Signaling
    Wenshu Chen; Fiscal Year: 2013
    ..Importantly, we found that this effect of BPDE can be potently inhibited by quercetin, a flavonoid found in vegetables and fruits...
  13. Beneficial effects of quercetin in COPD - a preliminary clinical trial
    DESCRIPTION (provided by applicant): Quercetin, a plant flavonoid widely found in fruits and vegetables, is a potent antioxidant and anti- inflammatory...
  14. Protein disulfide isomerases: A new class of antithrombotic targets
    Bruce Furie; Fiscal Year: 2013
    ..Component projects explore protein disulfide isomerase (PDl) as an antithrombotic target using isoquercetin, quercetin 3-rutinoside and quercetin as inhibitors of PDl. In Project #1, Dr. Bruce Furie, with Dr. Barbara Furie and Dr...
    Marco Colonna; Fiscal Year: 2013
    ..In Specific Aim 1 we will test the effect of I3C and the flavonoid quercetin on NK-22 expansion and function in vivo...
  16. Prevention of Melanoma by Targeting Tyrosinase with Dietary Quercetin
    Randy Burd; Fiscal Year: 2012
    ..b>Quercetin (Qct) is a ubiquitous and abundant dietary polyphenol which exhibits antioxidant properties, but it can also ..
  17. Drug-Dietary Flavonoid Intestinal Absorption Interaction
    ROSITA PROTEAU; Fiscal Year: 2002
    ..g., genistein, naringenin, quercetin, and epigallocatechin gallate, respectively) to gain an insight into structure-activity relationships in the ..
  18. Drug Interactions and Bioavailability of Cranberry
    Jennifer Donovan; Fiscal Year: 2005
    ..Clo), terminal elimination half-life (T1/2) and renal clearance (Clren) will be determined for: epicatechin, quercetin (total glycosides), procyanidin A2, and cyanidin-3-galactoside...
  19. Taste psychophysics of bitter phytochemicals
    MIRIAM LINSCHOTEN; Fiscal Year: 2005
    ..little is known about threshold and suprathreshold bitter perception of the phytochemicals naringin, limonin, quercetin, sinigrin and genistein...
  20. Quercetin Treatment of Airway Inflammation
    MARC HERSHENSON; Fiscal Year: 2006
    ..S. The purpose of this application is to study the effects of the dietary flavonol quercetin, an antioxidant and inhibitor of phosphatidylinositol (PI) 3-kinase, on airway inflammation...
  21. Influence of Dietary Flavonoids on the Expression of At*
    Carl Keen; Fiscal Year: 2002
    ..adequate diet, or a high fat-micronutrient marginal diet, supplemented or not with the flavonoids, quercetin and catechin...
  22. Are anthocyanins necessary for oral cancer chemoprevention by berries?
    CHRISTOPHER WEGHORST; Fiscal Year: 2009
    ..procatechuic, p-hydroxybenzoic, caffeic, p- coumaric, ferulic, chlorogenic, and ellagic acids), the flavonols (quercetin, kaempferol, mycetrin, and isorhamntin), and complex polyphenols (lignans, ellagitannin, and gallotannin)...
    BARBARA SNIDER; Fiscal Year: 1999
    ..that hsp70 synthesis is necessary for neuroprotection by heat stress by inhibiting hsp70 expression using quercetin (an inhibitor of hsp70 expression) and antisense oligonucleotides...
    Linda La Grange; Fiscal Year: 2000
    ..We now want to test the antioxidant effects of SY and four other antioxidant flavonoids; quercetin, myricetin, (+)-catechin, and apigenin on EtOH-exposed fetal rat brain and liver tissue...
  25. Cardiovascular Effects of Scutellaria baicelensis
    Chun Su Yuan; Fiscal Year: 2002
    ..In separate studies, we observed that quercetin, a plant flavonoid, inhibited endothelin-1 and stimulated tissue plasminogen activator in vascular endothelial ..
    DALE EISENMANN; Fiscal Year: 1990
    ..will be utilized: calcium antagonists cobalt, verapamil, lanthanum and tetracaine; Ca+2-Mg+2 ATPase inhibitors quercetin and ethacrynic acid; the hormone calcitonin; the anti-microtubular agent colchicine; and sodium fluoride...
    Raj Lakshman; Fiscal Year: 2007
    ..Whereas moderate wine consumption is cardioprotective, the benefits of both ethanol and quercetin components of wine on herogenic/antiatherogenic (AAA) factors are not clearly defined...
    MERRILL GERSHWIN; Fiscal Year: 2004
    ..study, the vitro/ex vivo inhibition of histamine release will be assayed, since one of its major constituents, quercetin, is known to be structurally related to cromolyn sodium and has been shown in in vitro studies to exhibit ..
    STEVEN SHIFF; Fiscal Year: 1999
    ..within these foods are likely abundant, the plant-derived phenolic compounds such as curcumin, rutin, and quercetin, are particularly compelling compounds to study...
  30. Interaction Between Irinotecan and Dietary Flavonoids
    Lalitha Iyer; Fiscal Year: 2004
    ..and the popular dietary flavonoids from soy (genistein and daidzein) and fruits and vegetables (chrysin and quercetin)...
    Suzanne Teuber; Fiscal Year: 2002
    ..present), and the above protein sources with a quantified walnut total polyphenolic fraction added (rich in quercetin and ellagic acid)...
    MICHAEL AIKENS; Fiscal Year: 2001
    ..It is conceivable that selected wine phenolic compounds, resveratrol, quercetin and catechin may have additional properties which may affect EC function in the long-term, in particular ..
  33. Cerebrovascular Mechanism of Grape Polyphenols-Alcohol
    SYLVAIN DORE; Fiscal Year: 2005
    ..This work, combined with the finding that ethanol in combination with resveratrol or quercetin would have synergistic effects, allows us to propose that some of the attributed neuroprotective effects of red ..
    Cecil Joseph; Fiscal Year: 2001
    ..Studies on closely related flavonoids (e.g., quercetin, naringenin, apignein, myricetin, luteolin, and hesperetin), have demonstrated that minor structural differences ..
  35. Functional synergism in prevention of hormone refractory CaP by phytochemicals
    Joseph Wu; Fiscal Year: 2007
    ..To test this hypothesis, we will study in this proposal combination of EGCG, genistein and quercetin, as phytochemicals present in a traditional Asian diet, for protection against HRPC...
    Francis Cheng; Fiscal Year: 2001
    ..previous investigation from this laboratory has found that four flavonoids, baicilein, luteolin, naringenin, and quercetin, chelate pro-oxidant iron ions into a complex that is not Fenton Reaction active...
  37. Targeting Antioxidant Therapy to Cardiac Mitochondria
    EVAN ABEL; Fiscal Year: 2006
    ..2) That mitochondrial targeting of naturally occurring anti-oxidants (Vitamin E, Coenzyme Q and the flavonoid Quercetin) via TPP conjugation will enhance their efficacy in reducing myocardial mitochondrial ROS generation in diabetic ..
    MELANIE YOUNG; Fiscal Year: 2006
    ..association between colon cancer and metabolic gene polymorphisms related to intake of the specific flavonoid quercetin, and the potential for gene-phytochemical interactions to alter the risk of colon cancer...
    Thomas Walle; Fiscal Year: 2005
    ..Complementary in vitro studies will include the identification of the bacterial pathway leading from quercetin to CO2 formation...
  40. Mast cells, antidepressants and chronic fatigue syndrome
    Theoharis Theoharides; Fiscal Year: 2007
    ..Future studies will build on these findings to develop in vitro and in vivo models of CFS and lead to clinical trials with select antidepressants or other molecules that inhibit brain mast cells. [unreadable] [unreadable] [unreadable]..
  41. Clinical Trial Development in Chronic Pelvic Pain Syndr*
    Daniel Shoskes; Fiscal Year: 2007
    ..As an example of a potential clinical trial, a study of water induced thermotherapy is outlined. ..
    Theoharis Theoharides; Fiscal Year: 2001
    ..They may also help explain some key events in the pathophysiology of migraines, the clinical symptoms of which are often precipitated by stress. ..
  43. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
    ..Our findings may be relevant to the pathophysiology of IC and may suggest new therapeutic approaches. ..
    Robert Flaumenhaft; Fiscal Year: 2007
    ..abstract_text> ..
  45. Chemical Genetic Analysis of Platelet Granule Secretion
    Robert Flaumenhaft; Fiscal Year: 2008
    ..Once identified, compounds will be tested in a previously established battery of platelet function tests and evaluated for antithrombotic potential in an in vivo murine model of thrombus formation. [unreadable] [unreadable] [unreadable]..
  46. Role of Glutaredoxin in Metabolic Oxidative Stress
    Yong Lee; Fiscal Year: 2007
    ..We believe that investigating the mechanisms of metabolic oxidative stress responses in tumor cells will provide insight into how tumor cells recognize metabolic oxidative stress and initiate signal transduction. ..
  47. 9.4 Tesla Fourier Transform Mass Spectrometer
    Stephen Barnes; Fiscal Year: 2002
    ..Overall, the FT-MS instrument will sustain the high quality of biomedical research that is a hallmark of UAB. ..
    Zora Djuric; Fiscal Year: 2002
    ..The use of biomarkers will allow to evaluate the cancer-protective effects of dietary modulation over a relatively short period of time. ..
  49. A sensitive triple quadrupole mass spectrometer
    Stephen Barnes; Fiscal Year: 2004
    ..It is anticipated that a commercial nanospray interface for use in nanoLC-MS analysis will be available by the fall of 2003. ..
  50. Anti-GM1b IgM for Detection of Localized Prostate Cancer
    Mepur Ravindranath; Fiscal Year: 2005
  51. Cutaneous Gene Therapy with Ultrasound: DNA Vaccination
    Samir Mitragotri; Fiscal Year: 2006
    ..3. Using an in vitro model, Epiderm, and in vivo mouse model, assess safety of skin exposure to low-frequency ultrasound. ..
  52. Scutellaria baicalensis and Colon Cancer Chemoprevention
    Diane Harris; Fiscal Year: 2005
    ..abstract_text> ..
    Mepur Ravindranath; Fiscal Year: 2006
    ..An active collaboration with Pacific Urology Institute is ongoing and will continue to be a participant in this study. ..
    Zigang Dong; Fiscal Year: 2010
    ..abstract_text> ..
  55. Linking folate deficiency to changes in gene expression
    KAREN KATULA; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  56. Molecular basis of arsenic-induced cell transformation
    Zigang Dong; Fiscal Year: 2007
    ..Such knowledge will facilitate the design of more effective and specific strategies with fewer side effects for chemoprevention of arsenic-induced cancer. ..
  57. The TGFbeta Pathway, Gene Variants and Colorectal Neopl*
    Loic Le Marchand; Fiscal Year: 2005
    ..abstract_text> ..