diosmin

Summary

Summary: A bioflavonoid that strengthens vascular walls.

Top Publications

  1. ncbi Chronic venous insufficiency and the therapeutic effects of Daflon 500 mg
    John J Bergan
    University of California, San Diego, CA, USA
    Angiology 56:S21-4. 2005
  2. ncbi Chronic venous insufficiency: worldwide results of the RELIEF study. Reflux assEssment and quaLity of lIfe improvEment with micronized Flavonoids
    G Jantet
    Union Internationale de Phlébologie, Paris, France
    Angiology 53:245-56. 2002
  3. ncbi HR, 0-(beta-hydroxyethyl)-rutosides, in comparison with diosmin+hesperidin in chronic venous insufficiency and venous microangiopathy: an independent, prospective, comparative registry study
    M R Cesarone
    Irvine2 Vasc Lab and Physiology, Department of Biomedical Sciences, Chieti University, San Valentino Vascular Screening Project, Italy
    Angiology 56:1-8. 2005
  4. ncbi Micronised purified flavonoid fraction: a review of its use in chronic venous insufficiency, venous ulcers and haemorrhoids
    Katherine A Lyseng-Williamson
    Adis International Limited, Mairangi Bay, Auckland, New Zealand
    Drugs 63:71-100. 2003
  5. ncbi [The principles of action and use of phlebotropic agents]
    D A Kharkevich
    Klin Med (Mosk) 82:4-10. 2004
  6. ncbi Antihyperglycemic effect of diosmin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats
    Leelavinothan Pari
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Chidambaram, 608002 Tamilnadu, India
    Biomed Pharmacother 64:477-81. 2010
  7. ncbi Simultaneous reversed-phase high-performance liquid chromatographic method for the determination of diosmin, hesperidin and naringin in different citrus fruit juices and pharmaceutical formulations
    Feras Imad Kanaze
    Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
    J Pharm Biomed Anal 33:243-9. 2003
  8. ncbi Clinical benefits of Daflon 500 mg in the most severe stages of chronic venous insufficiency
    A A Ramelet
    Angiology 52:S49-56. 2001
  9. ncbi Biological properties of flavonoids pertaining to inflammation
    J A Manthey
    33881
    Microcirculation 7:S29-34. 2000
  10. ncbi Semisynthesis of linarin, acacetin, and 6-iodoapigenin derivatives from diosmin
    Jérôme Quintin
    Laboratoire de Pharmacognosie, Centre d Etudes Pharmaceutiques, 5 rue J B Clement, 92296 Chatenay Malabry Cedex, France
    J Nat Prod 67:1624-7. 2004

Scientific Experts

Detail Information

Publications131 found, 100 shown here

  1. ncbi Chronic venous insufficiency and the therapeutic effects of Daflon 500 mg
    John J Bergan
    University of California, San Diego, CA, USA
    Angiology 56:S21-4. 2005
    ..Because venous insufficiency is linked to venous hypertension and an inflammatory reaction, it appears that Daflon 500 mg 2 tablets daily shows a great potential for accomplishing blockade of the inflammatory cascade...
  2. ncbi Chronic venous insufficiency: worldwide results of the RELIEF study. Reflux assEssment and quaLity of lIfe improvEment with micronized Flavonoids
    G Jantet
    Union Internationale de Phlébologie, Paris, France
    Angiology 53:245-56. 2002
    ..Patients were treated with micronized purified flavonoid fraction (MPFF), consisting of 450 mg of micronized diosmin and 50 mg of flavonoids expressed in hesperidin over 6 months...
  3. ncbi HR, 0-(beta-hydroxyethyl)-rutosides, in comparison with diosmin+hesperidin in chronic venous insufficiency and venous microangiopathy: an independent, prospective, comparative registry study
    M R Cesarone
    Irvine2 Vasc Lab and Physiology, Department of Biomedical Sciences, Chieti University, San Valentino Vascular Screening Project, Italy
    Angiology 56:1-8. 2005
    ..study was to investigate differences in efficacy between HR, (0-[beta-hydroxyethyl]-rutosides) and D+H (500 mg, diosmin+hesperidin) in patients with chronic venous insufficiency (CVI)...
  4. ncbi Micronised purified flavonoid fraction: a review of its use in chronic venous insufficiency, venous ulcers and haemorrhoids
    Katherine A Lyseng-Williamson
    Adis International Limited, Mairangi Bay, Auckland, New Zealand
    Drugs 63:71-100. 2003
    ..purified flavonoid fraction (MPFF) [Daflon 500 mg], an oral phlebotropic drug consisting of 90% micronised diosmin and 10% flavonoids expressed as hesperidin, improves venous tone and lymphatic drainage, and reduces capillary ..
  5. ncbi [The principles of action and use of phlebotropic agents]
    D A Kharkevich
    Klin Med (Mosk) 82:4-10. 2004
  6. ncbi Antihyperglycemic effect of diosmin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats
    Leelavinothan Pari
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Chidambaram, 608002 Tamilnadu, India
    Biomed Pharmacother 64:477-81. 2010
    The purpose of this study was to investigate the effect of diosmin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. Diosmin was administered to streptozotocin-induced (45 mg/kg b...
  7. ncbi Simultaneous reversed-phase high-performance liquid chromatographic method for the determination of diosmin, hesperidin and naringin in different citrus fruit juices and pharmaceutical formulations
    Feras Imad Kanaze
    Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
    J Pharm Biomed Anal 33:243-9. 2003
    b>Diosmin, hesperidin and naringin are flavonoid glycosides that occur naturally in citrus fruits...
  8. ncbi Clinical benefits of Daflon 500 mg in the most severe stages of chronic venous insufficiency
    A A Ramelet
    Angiology 52:S49-56. 2001
    ..Micronized purified flavonoid fraction (MPFF, 450 mg diosmin plus 50 mg hesperidin-Daflon 500 mg) is a potent venotropic drug used in the treatment of venous insufficiency...
  9. ncbi Biological properties of flavonoids pertaining to inflammation
    J A Manthey
    33881
    Microcirculation 7:S29-34. 2000
    ..These modes of inhibition provide the mechanisms by which flavonoids inhibit the inflammation response and suggest that this class of molecules may be effective in the treatment of CVI...
  10. ncbi Semisynthesis of linarin, acacetin, and 6-iodoapigenin derivatives from diosmin
    Jérôme Quintin
    Laboratoire de Pharmacognosie, Centre d Etudes Pharmaceutiques, 5 rue J B Clement, 92296 Chatenay Malabry Cedex, France
    J Nat Prod 67:1624-7. 2004
    Semisynthesis of linarin and acacetin from the Citrus flavonoid diosmin was performed via, as first intermediate, the 3'-O-phenyltetrazolyl ether of diosmin...
  11. ncbi Therapeutic approach to chronic venous insufficiency and its complications: place of Daflon 500 mg
    J J Bergan
    Department of Surgery, University of California, San Diego, USA
    Angiology 52:S43-7. 2001
    ..Daflon 500 mg, the purified micronized flavonoid fraction containing 90% diosmin and 10% hesperidin, acts favorably in venous ulcer treatment by inhibiting the synthesis of prostaglandins and ..
  12. doi Ameliorative effect of diosmin, a citrus flavonoid against streptozotocin-nicotinamide generated oxidative stress induced diabetic rats
    Subramani Srinivasan
    Department of Biochemistry and Biotechnology, Annamalai University, Tamilnadu, India
    Chem Biol Interact 195:43-51. 2012
    ..The aim of the study was to evaluate the effect of diosmin (DS) in oxidative stress in streptozotocin-nicotinamide (STZ-NA)-induced diabetic rats by measuring the lipid ..
  13. doi Diosmin, a bioflavonoid reverses alterations in blood pressure, nitric oxide, lipid peroxides and antioxidant status in DOCA-salt induced hypertensive rats
    Thangarasu Silambarasan
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608 002, Tamil Nadu, India
    Eur J Pharmacol 679:81-9. 2012
    The present study was aimed to evaluate the antihypertensive effect of diosmin in deoxycorticosterone acetate (DOCA)-salt induced hypertension in male Wistar rats...
  14. ncbi PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K-Akt-MDM2 signaling suppression
    Tran Duc Dung
    School of Chinese Medicine, China Medical University, Taichung, Taiwan
    Food Chem Toxicol 50:1802-10. 2012
    ..This study examines the in vitro and in vivo mechanisms of diosmin on human hepato-cellular carcinoma HA22T cell proliferation inhibition...
  15. pmc Diosmin protects rat retina from ischemia/reperfusion injury
    Nianting Tong
    Department of Ophthalmology, Shanghai Jiaotong University Affiliated Shanghai First People s Hospital, Shanghai, China
    J Ocul Pharmacol Ther 28:459-66. 2012
    b>Diosmin, a natural flavone glycoside, possesses antioxidant activity and has been used to alleviate ischemia/reperfusion (I/R) injury...
  16. ncbi Effects of diosmin, a flavonoid glycoside in citrus fruits, on P-glycoprotein-mediated drug efflux in human intestinal Caco-2 cells
    Hye Hyun Yoo
    Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, PO Box 131, Chungryang, Seoul 130 650, Korea
    J Agric Food Chem 55:7620-5. 2007
    ..Among the flavonoids tested, diosmin significantly increased the accumulation of rhodamine-123 in Caco-2 cells...
  17. ncbi Treatment of metastatic melanoma B16F10 by the flavonoids tangeretin, rutin, and diosmin
    Cristina Martínez Conesa
    Pathology Department, Faculty of Medicine, University of Murcia, 30100 Espinardo, Murcia, Spain
    J Agric Food Chem 53:6791-7. 2005
    ..Antimetastatic effects of the flavonoids tangeretin, rutin, and diosmin were analyzed, and at the same time an analysis of the metastatic activity of ethanol was performed, considered ..
  18. ncbi Diosmin pretreatment affects bioavailability of metronidazole
    K Rajnarayana
    Drug Metabolism and Clinical Pharmacokinetics Division, University College of Pharmaceutical Sciences, Kakatiya University, AP 506009, Warangal, India
    Eur J Clin Pharmacol 58:803-7. 2003
    To screen for inhibitory effects of diosmin on cytochrome P(450)-mediated metabolism of metronidazole in healthy volunteers.
  19. ncbi Diosmin and diosmetin are agonists of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity
    H P Ciolino
    Cellular Defense and Carcinogenesis Section, Division of Basic Sciences, National Cancer Institute Frederick Cancer Research and Development Center, NIH, Maryland 21702 1201, USA
    Cancer Res 58:2754-60. 1998
    We investigated the effect of the chemopreventive compound diosmin and its aglycone form, diosmetin, on the carcinogen activation pathway mediated by the aryl hydrocarbon receptor (AhR) in MCF-7 human breast epithelial cancer cells...
  20. ncbi Micronized purified flavonoid fraction (MPFF): a review of its pharmacological effects, therapeutic efficacy and benefits in the management of chronic venous insufficiency
    Konstantinos Katsenis
    Vascular Surgery Dept of 2nd Surgical Clinic of Athens University, Areteion Hospital, 76 Vas Sofias Str, 11521 Athens, Greece
    Curr Vasc Pharmacol 3:1-9. 2005
    ..An explanation for the ability to speed ulcer healing comes from the protection Daflon 500 mg exerts on the microcirculation...
  21. ncbi The social and economic burden of venous leg ulcers: focus on the role of micronized purified flavonoid fraction adjuvant therapy
    Marian Simka
    Out Patient Department of Angiology, Pszczyna ul Wodzislawska 78 43 200 Pszczyna, Poland
    Am J Clin Dermatol 4:573-81. 2003
    ..8 US dollars vs 1871.9 US dollars per ulcer healed). Hence, the addition of MPFF adjuvant therapy to the treatment of venous leg ulcers would be effective and potentially cost saving...
  22. ncbi From skin disorders to venous leg ulcers: pathophysiology and efficacy of Daflon 500 mg in ulcer healing
    Philip D Coleridge Smith
    Department of Surgery, The Middlesex Hospital, London, UK
    Angiology 54:S45-50. 2003
    ..There is clinical evidence that MPFF modifies venous leg ulcer healing...
  23. ncbi Effects of citrus flavonoids on redox homeostasis of toxin-injured liver in rat
    Erika Rapavi
    II Department of Medicine, Semmelweis University, Szentkiralyi u 46, H 1088 Budapest, Hungary
    Acta Biol Hung 57:415-22. 2006
    In order to evaluate the effect of diosmin-hesperidin containing drug on redox balance and Cu, Zn, Fe and Mn concentrations of toxin-injured liver, Wistar albino rats were subjected to thioacetamide administration (500 mg TAA/l in their ..
  24. ncbi Flavonoid treatment in patients with healed venous ulcer: flow cytometry analysis suggests increased CD11b expression on neutrophil granulocytes in the circulation
    Gudmundur Danielsson
    Department of Vascular Diseases, Malmo University Hospital, Malmo, Sweden
    Vasc Med 8:83-8. 2003
    ..Ten patients with a healed venous ulcer were treated with flavonoid substance (90% diosmin), 1000 mg three times daily for 30 days...
  25. ncbi [Congenital anomalies of the inferior vena cava: diagnosis and medical treatment]
    A A Baeshko
    Federal Facility Regional Research and Production Centre, Mother and Infant Care, Belorussian State Medical University, Minsk, Belarus
    Angiol Sosud Khir 13:91-5. 2007
    ..When the diagnosis of IVC aplasia is confirmed, primary medical treatment should consist in prescribing venotonic agents, elastic compression and in cases of deep veins thrombosis -anticoagulant therapy...
  26. ncbi Effects of purified micronized flavonoid fraction (Detralex) on prophylactic treatment of adjuvant arthritis with methotrexate in rats
    Jozef Rovensky
    National Institute of Rheumatic Diseases, Piest any, Slovak Republic
    Isr Med Assoc J 10:377-80. 2008
    ..It is suggested that the beneficial effect of purified micronized flavonoid fraction may be involved in the treatment of adjuvant arthritis in rats...
  27. ncbi Surgical correction of varicose vein disease under micronized diosmin protection (results of the Russian multicenter controlled trial DEFANS)
    A V Pokrovsky
    Department of Faculty Surgery, Faculty for Postgraduate Training of Physicians, Russian State Medical University, Moscow
    Angiol Sosud Khir 13:47-55. 2007
    ..The main group (n=200) received micronized diosmin (Detralex, 1000 mg/day) for 2 weeks before and 30 days after the procedure; control group (n=45) did not receive ..
  28. ncbi Effects of plant-derived phenols on rat liver cytochrome P450 2B1 activity
    H T Huynh
    Department of Physiology and Pharmacology, Loma Linda University, CA 92350, USA
    Anticancer Res 22:1699-703. 2002
    ..In this report, the plant-derived phenols catechin, chlorogenic acid, diosmin, epigallo-catechin gallate (EGCG), naringenin, quercetin and resveratrol were studied for their effects on the ..
  29. ncbi Flavonoid glycosides inhibit oral cancer cell proliferation--role of cellular uptake and hydrolysis to the aglycones
    Alyson M Browning
    Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29425, USA
    J Pharm Pharmacol 57:1037-42. 2005
    ..b>Diosmin, the 7-rutinoside of diosmetin, surprisingly, was more potent and effective than diosmetin...
  30. ncbi Chronic venous disease, inflammation, and Daflon 500 mg
    A N Nicolaides
    Angiology 56:S1. 2005
  31. ncbi Comparison of the absorption of micronized (Daflon 500 mg) and nonmicronized 14C-diosmin tablets after oral administration to healthy volunteers by accelerator mass spectrometry and liquid scintillation counting
    R C Garner
    The Centre for Biomedical Accelerator Mass Spectrometry CBAMS Ltd Sand Hutton, York Y041 ILZ, United Kingdom
    J Pharm Sci 91:32-40. 2002
    Daflon 500 mg, is a micronized purified flavonoid fraction, containing 90% w/w diosmin and 10% w/w of flavonoids expressed as hesperidin, used clinically in the treatment of chronic venous insufficiency and hemorrhoidal disease...
  32. ncbi The effect of the flavonoid diosmin, grape seed extract and red wine on the pulmonary metastatic B16F10 melanoma
    C Martinez
    Pathology Department, Faculty of Medicine, University of Murcia, Espinardo, Spain
    Histol Histopathol 20:1121-9. 2005
    ..To study the effect of different phenolic compounds and red wine on pulmonary metastatic melanoma...
  33. ncbi Daflon for haemorrhoids: a prospective, multi-centre observational study
    A W N Meshikhes
    Department of Surgery, Dammam Central Hospital, Dammam, Eastern Province, Saudi Arabia
    Surgeon 2:335-8, 361. 2004
    ..The aim of this study was to confirm the efficacy of Daflon in the treatment of haemorrhoidal symptoms...
  34. ncbi Re: Meshikhes A-W. N. Daflon for haemorrhoids: a prospective, multi-centre observational study. Surg JR Coll Surg Edinb Irel 2004;2(6): 355-38
    A A Ibuowo
    Surgeon 3:363; author reply 363. 2005
  35. ncbi Antiradical and anti-H2O2 properties of polyphenolic compounds from an aqueous peppermint extract
    Zbigniew Sroka
    Department of Pharmacognosy, Wrocław Medical University, pl Nankiera 1, 50 140 Wrocław, Poland
    Z Naturforsch C 60:826-32. 2005
    Polyphenolic compounds such as eriocitrin, luteolin-7-O-rutinoside, diosmin, hesperidin, narirutin, isorhoifolin, rosmarinic and caffeic acids were identified in an aqueous extract (Ex) obtained from peppermint leaves (Menthae x ..
  36. doi Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones
    H Serra
    IBET ITQB, Av da Republica, EAN, Apartado 127, 2781 901 Oeiras, Portugal
    Bioorg Med Chem 16:4009-18. 2008
    Three glycosilated flavonoids (diosmin, hesperidin and naringin) and respective aglycones were characterized in terms of their apparent ionisation constants and bidirectional permeability using the cellular model Caco-2 as well as the ..
  37. ncbi Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells
    Qiao Zheng
    First Department of Pathology, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu 500 8705, Japan
    J Cancer Res Clin Oncol 128:539-46. 2002
    ..shown that naturally-occurring and synthetic chemicals such as auraptene (AUR), nobiletin (NOB), hesperidin (HE), diosmin (DIO), indole-3-carbinol (I3C), 1'-acetoxychavicol acetate (ACA), 2,5-di-O-acetyl-D-1,4-glucaro-6,3-dilactone (..
  38. ncbi Antioxidant activity and radioprotective effects against chromosomal damage induced in vivo by X-rays of flavan-3-ols (Procyanidins) from grape seeds (Vitis vinifera): comparative study versus other phenolic and organic compounds
    J Castillo
    Research and Development Department of Furfural Español S A, Camino Viejo de Pliego s n, 80320 Alcantarilla, Murcia, Spain
    J Agric Food Chem 48:1738-45. 2000
    ..The most effective compounds were, in order: GSE > rutin > (+)-catechin > diosmin >/= ascorbic acid...
  39. ncbi Influence of some bioflavonoids on the transport of nitrendipine
    Kandhagatla Rajnarayana
    Department of Pharmacology and Clinical Pharmacy, University College ofPharmaceutical Sciences, Kakatiya University, Warangal, India
    Drug Metabol Drug Interact 23:299-310. 2008
    ..b>diosmin, quercetin, chrysin, methyl hesperidin and gossypin, was introduced into the mucosal side...
  40. doi Cytotoxic activity of flavonoids from the flowers of Chrysanthemum morifolium on human colon cancer Colon205 cells
    Yuan Yuan Xie
    Department of Traditional Chinese Medicines, Shenyang Pharmaceutical University, China
    J Asian Nat Prod Res 11:771-8. 2009
    ..together with five known flavonoids, luteolin (2), diosmetin (3), diosmetin 7-O-beta-d-glucopyranoside (4), diosmin (5), and scolimoside (6), and four known caffeoylquinic acid derivatives, macranthoin F (7), 3,5-dicaffeoylquinic ..
  41. ncbi [Studies on chemical components of Lobelia chinensis]
    Yanyan Jiang
    School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China
    Zhongguo Zhong Yao Za Zhi 34:294-7. 2009
    ..To study on the chemical constituents of Lobelia chinensis...
  42. ncbi [The flavonoids effect against vinblastine, cyclophosphamide and paracetamol toxicity by inhibition of lipid-peroxydation and increasing liver glutathione concentration]
    M Lahouel
    Laboratoire de Pharmacologie et Phytochimie, Departement de Biologie, Université de Jijel, 18000 Jijel, Algerie
    Pathol Biol (Paris) 52:314-22. 2004
    ..Flavonoïds seem to act by activation of the turn over of the glutathion and enzymes stimulating particularly glutathion-s-transferases permitting the captation of the reactive metabolites of the studied drugs...
  43. ncbi Effects of dosmalfate, a new cytoprotective agent, on acute and chronic trinitrobenzene sulphonic acid-induced colitis in rats
    Isabel Villegas
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Profesor García González Street, 41012 Seville, Spain
    Eur J Pharmacol 460:209-18. 2003
    ..In this study, we examined the effects of dosmalfate, a new flavonoid derivative compound (diosmin heptakis) with antioxidant and cytoprotective properties, on acute and chronic experimental trinitrobenzene ..
  44. pmc Micronized purified flavonoid fraction in pretreating CABG patients
    Mustafa Sirlak
    Department of Cardiovascular Surgery, Ankara University School of Medicine, Dikimevi Ankara 06340, Turkey
    Tex Heart Inst J 37:172-7. 2010
    ..Orally administered Daflon might provide better outcomes for patients who have impaired cardiac function before undergoing cardiac operations that require cardiopulmonary bypass...
  45. ncbi Screening of various phenolic acids and flavonoid derivatives for their anticholinesterase potential
    Ilkay Orhan
    Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey
    Z Naturforsch C 62:829-32. 2007
    ..genistein, biochanin A, naringin, apigenin, quercetin, luteolin-7-O-rutinoside, kaempferol-3-O-galactoside, diosmin, silibinin, and silymarin) against AChE and BChE at 1 mg/ml concentration using a microplate-reader assay based ..
  46. doi Effects of micronised purified flavonoid fraction on pain, semen analysis and scrotal color Doppler parameters in patients with painful varicocele; results of a randomized placebo-controlled study
    Haluk Soylemez
    Department of Urology, Medical Faculty, Dicle University, Diyarbakir, Turkey
    Int Urol Nephrol 44:401-8. 2012
    ..Aim of this study is to evaluate the effects of micronised purified flavonoid fraction (Daflon(®)) on pain, semen analysis and color Doppler parameters in patients with painful varicocele...
  47. ncbi Clinical effectiveness of a highly standardized and bioavailable mixture of flavonoids and triterpenes in the management of acute hemorroidal crisis
    Francesco Di Pierro
    Scientific Department, Velleja Research, Pontenure PC, Italy
    Acta Biomed 82:35-40. 2011
    ..Effective and not invasive treatment control of the acute crisis could be of practical use in order to avoid or to delay invasive procedures to a time more convenient for the patient and/or for the surgeon...
  48. ncbi Diosmin exhibits anti-hyperlipidemic effects in isoproterenol induced myocardial infarcted rats
    S Sharmila Queenthy
    Department of Chemistry, Manonmanium Sundarnar University, Tirunelveli, Tamil Nadu, India Department of Biotechnology, Waljat College of Applied Sciences, Muscut, Oman
    Eur J Pharmacol 718:213-8. 2013
    The aim of the present study was to evaluate the protective effects of diosmin on experimentally induced myocardial infarcted rats. Diosmin (5 and 10mg/kg body weight) was administered orally as pretreatment daily for a period of 10 days...
  49. ncbi Effects of verapamil, nifedipine, and daflon on the viability of reverse-flow island flaps in rats
    Hidir Kilinc
    From the Departments of Plastic Surgery, Pathology, and Biochemistry, Medical Faculty, Inonu University, Malatya, Turkey
    Ann Plast Surg 71:610-4. 2013
    ..However, nifedipine did not make a significant contribution to the flap viability. The results of this study will contribute to the literature about the hemodynamics of reverse-flow island flaps and guide further studies on the issue. ..
  50. ncbi Diosmin protects against ethanol-induced hepatic injury via alleviation of inflammation and regulation of TNF-α and NF-κB activation
    Mir Tahir
    Molecular Carcinogenesis and Chemoprevention Division, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi 110062, India
    Alcohol 47:131-9. 2013
    The present investigation was designed to evaluate the efficacy of diosmin against ethanol-induced hepatotoxicity in rats by modulating various mechanisms including ethanol metabolizing enzymes, generation of free radicals, imbalance in ..
  51. ncbi Diosmin--isolation techniques, determination in plant material and pharmaceutical formulations, and clinical use
    Anna Bogucka-Kocka
    Chair and Department of Pharmaceutical Botany, Medical University, Lublin, 20 093 Chodźki 1, Poland
    Nat Prod Commun 8:545-50. 2013
    b>Diosmin is a naturally occurring flavone glycoside used in the treatment of venous diseases...
  52. ncbi The protective effect of diosmin on hepatic ischemia reperfusion injury: an experimental study
    Yusuf Tanrikulu
    Department of General Surgery, Ankara Training and Research Hospital, Ministry of Health, Ulucanlar Street, 06340, Ankara, Turkey
    Bosn J Basic Med Sci 13:218-24. 2013
    ..Our study aimed to investigate the protective effects of diosmin, a phlebotrophic drug with antioxidant and anti-inflammatory effects, in a liver IRI model...
  53. doi Enhancement of the water solubility of flavone glycosides by disruption of molecular planarity of the aglycone moiety
    Guy Lewin
    Laboratoire de Pharmacognosie, Faculte de Pharmacie, Université Paris Sud BIOCIS UMR 8076 CNRS LabEx LERMIT, Avenue J B Clement, 92296 Chatenay Malabry Cedex, France
    J Nat Prod 76:8-12. 2013
    ..We applied this strategy to some natural flavone glycosides, especially diosmin, a highly insoluble citroflavonoid prescribed as an oral phlebotropic drug...
  54. ncbi Central nervous system depressant action of flavonoid glycosides
    Sebastian P Fernandez
    Instituto de Quimica y Fisicoquimica Biologicas, Facultad de Farmacia y Bioquimica, Buenos Aires, Argentina
    Eur J Pharmacol 539:168-76. 2006
    ..The glycosides 2S-neohesperidin, 2S-naringin, diosmin, gossipyn and rutin exerted a depressant action on the CNS of mice following i.p...
  55. ncbi [Semisynthetic Diosmin (Phlebodia 600) for therapy of lower limb chronic venous insufficiency]
    A I Kirienko
    Angiol Sosud Khir 12:73-5. 2006
    The study was held to assess clinical effectiveness of coaggregated semisynthetic Diosmin (Phlebodia 600) for patients with II-III CEAP classes of chronic venous insufficiency (CVI), caused by lower limb variceal diseases...
  56. pmc Dietary bioflavonoids inhibit Escherichia coli ATP synthase in a differential manner
    Nagababu Chinnam
    Department of Biological Sciences, Box 70703, East Tennessee State University, Johnson City, TN 37614, USA
    Int J Biol Macromol 46:478-86. 2010
    ..5 mM)>epicatechin (IC50 approximately 4.0 mM). Inhibition by hesperidin, chrysin, kaempferol, diosmin, apigenin, genistein, or rutin was partial in the range of 40-60% and inhibition by galangin, daidzein, or ..
  57. ncbi Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn
    Ampai Panthong
    Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
    J Ethnopharmacol 110:264-70. 2007
    ..e. 90% diosmin and 10% hesperidin. The results obtained confirmed the traditional use of C...
  58. ncbi The effect of purified micronized flavonoid fraction on the healing of anastomoses in the colon in rats
    Aydin Inan
    Department of General Surgery, Fatih University School of Medicine, Bestepe, Emek 06510, Ankara, Turkiye
    Surg Today 36:818-22. 2006
    ..We studied the effects of a clinically used, micronized, purified flavonoid fraction on the healing of colonic anastomosis in rats...
  59. ncbi Determination of trace levels of diosmin in a pharmaceutical preparation by adsorptive stripping voltammetry at a glassy carbon electrode
    M S el-Shahawi
    Department of Chemistry, Faculty of Science, King Abdulaziz UniversityJeddah, Kingdom of Saudi Arabia
    Anal Sci 22:1351-4. 2006
    A systematic study on the electrochemical behavior of diosmin in Britton-Robinson buffer (pH 2.0-10.0) at a glassy carbon electrode (GCE) was made...
  60. ncbi Toxicological aspects of flavonoid interaction with biomacromolecules
    Petr Hodek
    Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic
    Neuro Endocrinol Lett 27:14-7. 2006
    ..Thus, their potential harmful effect on the human body should be examined in detail...
  61. ncbi The effect of citrus flavonoids on the redox state of alimentary-induced fatty liver in rats
    E Rapavi
    Biochemical Research Group, II Department of Medicine, Semmelweis University Medical School, H 1088, Budapest, Szentkiralyi u 46, Hungary
    Nat Prod Res 21:274-81. 2007
    Both chronic venous insufficiency (CVI) and fatty liver may develop at the same time. Hesperidin and diosmin are used for the treatment CVI...
  62. ncbi Micronized diosmin (Detralex) for vein-related trophic ulcers: European experience
    V S Savel'ev
    Chair of Faculty Surgery, Department of Continuing Education, Russian State Medical University, Moscow A V Vishnevsky Institute of Surgery, RAMS, Moscow, Russia
    Angiol Sosud Khir 12:53-60. 2006
    The paper presents a meta-analysis of 5 large European studies (N - 723) on the micronized diosmin administration to patients with venous trophic ulcers (CEAP class VI)...
  63. ncbi Mechanisms in experimental venous valve failure and their modification by Daflon 500 mg
    L Pascarella
    Department of Surgery University of California San Diego, La Jolla, CA, USA
    Eur J Vasc Endovasc Surg 35:102-10. 2008
    ..To characterize the acute response of the vein wall to venous hypertension and associated altered fluid shear stress and to test the effect of micronized purified flavonoid fraction (MPFF, Daflon 500), on this response...
  64. ncbi Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids
    Sukij Panpimanmas
    Department of Surgery, College of Medicine, Rangsit University, Rajavithi Hospital, Bangkok, Thailand
    J Med Assoc Thai 93:1360-7. 2010
    ..To investigate efficacy and side effects of Cissus quadrangularis L. and micronised purified flavanoid fraction (MPFF) in treatment of hemorrhoids...
  65. pmc How we can improve patients' comfort after Milligan-Morgan open haemorrhoidectomy
    Ma Mu Ti Jiang A Ba-Bai-Ke-Re
    Department of Anorectal Surgical, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China
    World J Gastroenterol 17:1448-56. 2011
    To demonstrate the value of Diosmin (flavonidic fraction) in the management of post-haemorhoidectomic symptoms.
  66. ncbi Antihepatotoxic activity and chemical constituents of Buddleja asiatica Lour
    Maher M El-Domiaty
    Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
    Z Naturforsch C 64:11-9. 2009
    ..aucubin), phenylpropanoids (isoacteoside and acteoside), a triterpene saponin (mimengoside A), flavonoids (diosmin and linarin) in addition to the free sugars mannitol and sucrose...
  67. pmc Ca(2+)-dependent contraction by the saponoside escin in rat vena cava: implications in venotonic treatment of varicose veins
    Joseph D Raffetto
    Division of Vascular and Endovascular Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Vasc Surg 54:489-96. 2011
    Saponosides (horse chestnut seed extract, escin) and flavonoids (diosmin, Daflon 500, Servier, France) exhibit venotonic properties that have been utilized in treatment of varicose veins...
  68. ncbi Medicamentous treatment of chronic venous insufficiency using semisynthetic diosmin--a prospective study
    Z V Maksimovic
    Clinic for Vascular Surgery of the Institute for Cardiovascular Diseases, Clinical Center of Serbia, Belgrade
    Acta Chir Iugosl 55:53-9. 2008
    ..Chronic venous insufficiency (HVI) is manifested by the progressive signs of venous stasis. This disorder is treated by: compressive bandaging, medicaments, sclerotherapy, surgery, etc...
  69. doi Simultaneous determination of the flavonoid aglycones diosmetin and hesperetin in human plasma and urine by a validated GC/MS method: in vivo metabolic reduction of diosmetin to hesperetin
    Marios Spanakis
    School of Pharmacy, Department of Pharmacognosy and Pharmacology, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece
    Biomed Chromatogr 23:124-31. 2009
    Diosmetin and hesperetin are the aglycones of the flavonoid glycosides diosmin and hesperidin which occur naturally in citrus fruit...
  70. doi The effect of a flavonoid fractions diosmin + hesperidin on radiation-induced acute proctitis in a rat model
    Atakan Sezer
    Department of General Surgery, Faculty of Medicine, Trakya University, Edirne, Turkey
    J Cancer Res Ther 7:152-6. 2011
    To explore the protective effect of a flavonoid fractions diosmin + hesperidin (Daflon), against radiation-induced acute proctitis in an experimental rat model.
  71. ncbi Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: potential prophylactic ingredients for functional foods application
    Deena Ramful
    Department of Agricultural and Food Science, Faculty of Agriculture, University of Mauritius, Reduit, Mauritius
    Toxicology 278:75-87. 2010
    ..Contents in hesperidin ranged from 83 ± 0.06 to 234 ± 1.73 mg/g FW. Poncirin, didymin, diosmin, isorhoifolin and narirutin were also present in all extracts whereas naringin was present only in one mandarin ..
  72. doi Synergistic effect of diosmin and interferon-alpha on metastatic pulmonary melanoma
    Nuria Alvarez
    University of Murcia Institute of Research into Aging, Department of Pathology, Faculty of Medicine, University of Murcia, Murcia, Spain
    Cancer Biother Radiopharm 24:347-52. 2009
    ..Our aim was to study the combined treatment of metastatic lung melanoma with IFN-alpha and diosmin in a murine model...
  73. ncbi Pharmacological agents in the treatment of venous disease: an update of the available evidence
    Manjit S Gohel
    Imperial Vascular Unit, Charing Cross Hospital, Fulham Palace Road, London, UK
    Curr Vasc Pharmacol 7:303-8. 2009
    ..Further research is needed to define the role of venoactive drugs in clinical care and improve our understanding of the pathophysiology of venous disease to help identify new therapeutic avenues...
  74. ncbi Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity
    O Benavente-García
    Research and Development Department of Nutrafur Furfural Español S A, Camino Viejo de Pliego s n, 80320 Alcantarilla, Murcia, Spain
    J Agric Food Chem 56:6185-205. 2008
    ..However, generally, the flavones, such as diosmin, apigenin, or luteolin, exhibit higher biological activity, even though they occur in much lower concentrations...
  75. ncbi [Results of administering Phlebodia 600 in fertile women with orthostasis-dependent phlebopathy]
    Iu T Tsukanov
    Angiol Sosud Khir 13:107-12. 2007
    ..Noted was positive dynamics of the preparation with the necessity of continuing to take oral contraceptives by the medical indications...
  76. doi Simultaneous determination of flavonoids and phenylethanoids in the flowers of Verbascum densiflorum and V. phlomoides by high-performance liquid chromatography
    Barbara Klimek
    Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Łódź, ul Muszyńskiego 1, 90 151 Łódź, Poland
    Phytochem Anal 21:150-6. 2010
    ..However, knowledge about the contents of phenolics in flowers is limited and no HPLC method for their analysis is available...
  77. ncbi Agenesis of the renal segment of inferior vena cava associated with venous stasis
    G Milio
    Biomedical Department of Internal and Special Medicine Di Bi M I S, P Giaccone University Hospital, University of Palermo, Palermo, Italy
    Int Angiol 29:385-8. 2010
    ..We describe a 42-year-old man with chronic venous insufficiency, without DVT, caused by congenital absence of renal segment of the IVC...
  78. ncbi The impact of micronized purified flavonoid fraction on the treatment of acute haemorrhoidal episodes
    Zhu Ming Jiang
    Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
    Curr Med Res Opin 22:1141-7. 2006
    ..To evaluate the efficacy and the tolerability of micronized purified flavonoid fraction (MPFF) on symptoms and signs of acute haemorrhoidal disease (HD)...
  79. ncbi [Risk factors of chronic venous insufficiency of the lower extremities and possibilities of its medication in therapeutic practice]
    R G Oganov
    Ter Arkh 78:68-72. 2006
    ..To verify incidence of risk factors of chronic venous insufficiency (CVI) of the lower limbs and efficacy of outpatient treatment...
  80. ncbi Radioprotective effects in vivo of phenolics extracted from Olea europaea L. leaves against X-ray-induced chromosomal damage: comparative study versus several flavonoids and sulfur-containing compounds
    O Benavente-García
    Research and Development Department, Furfural Español S A, Camino Viejo de Pliego s n, 80320 Alcantarilla, Murcia, Spain
    J Med Food 5:125-35. 2002
    The radioprotective effects of a polyphenolic extract of Olea europaea L. leaves (OL); the flavonoids diosmin and rutin, which are widely used as pharmaceuticals; and the sulfur-containing compounds dimethylsulfoxide (DMSO) and 6-n-..
  81. ncbi Treatment of abnormal uterine bleeding with micronized flavonoids
    G G Mukherjee
    Int J Gynaecol Obstet 89:156-7. 2005
  82. ncbi The effect of diosmin hesperidin on intestinal ischaemia--reperfusion injury
    M Pehlivan
    Department of General Surgery, Medical School, Abant Izzet Baysal University, Duzce, Turkey
    Acta Chir Belg 104:715-8. 2004
    The effect of Diosmin Hesperidin on intestinal ischaemia reperfusion injury was evaluated in an experimental model in rats.
  83. ncbi Neutrophil activation and mediators of inflammation in chronic venous insufficiency
    P D Smith
    Department of Surgery, University College London Medical School, The Middlesex Hospital, London, UK
    J Vasc Res 36:24-36. 1999
    ..It has recently been shown that the venotonic drug Daflon 500 mg (450 mg diosmin, 50 mg hesperidin, Servier, France) influences these processes...
  84. ncbi A new flavonoid derivative, dosmalfate, attenuates the development of dextran sulphate sodium-induced colitis in mice
    Isabel Villegas
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Calle Profesor García González, 41012 Seville, Spain
    Int Immunopharmacol 3:1731-41. 2003
    ..The beneficial effects seem to be related to a decrease of neutrophil infiltration, absence of up-regulation of IL-1 beta and increase of PG production in colon mucosa...
  85. ncbi Protective effect of diosmetin on in vitro cell membrane damage and oxidative stress in cultured rat hepatocytes
    P Villa
    C N R National Research Council Center of Cytopharmacology, Department of Pharmacology, Milan, Italy
    Toxicology 73:179-89. 1992
    Primary cultures of rat hepatocytes were used to study the effects of the flavonoids diosmin and its main metabolite diosmetin on the cell membrane damage caused by erythromycin estolate (EE) and oxidative stress caused by tert-..
  86. ncbi From symptoms to leg edema: efficacy of Daflon 500 mg
    Andrew N Nicolaides
    The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
    Angiology 54:S33-44. 2003
    ..Daflon 500 mg, a well-established oral flavonoid that consists of 90% micronized diosmin and 10% flavonoids expressed as hesperidin, may be prescribed from the very beginning of the disease for the ..
  87. ncbi [The theory of lymphangion and current approaches to the pathogenesis, diagnosis and treatment of lymphedema of the lower extremities]
    N A Bubnova
    I P Pavlov Sankt Peterburg State Medical University, Russia
    Angiol Sosud Khir 9:66-70. 2003
    ..Based on the aforesaid the new approaches to the diagnosis and selection of the treatment methods for lymphedema of the lower extremities have been formulated...
  88. ncbi Effect of a micronized purified flavonoid fraction on in vivo platelet functions in the rat
    L McGregor
    INSERM U331, Faculty of Medicine RTH Laennec, Lyon, France
    Thromb Res 94:235-40. 1999
    ..01). In addition, fibrinogen binding to 2.5 or 5 microM ADP-stimulated platelets also was reduced significantly (p<0.05 and 0.01, respectively). These results show that MPFF inhibits in vivo rat platelet functions...
  89. ncbi Effects of Daflon on oxidative stress induced by hindlimb ischemia/reperfusion
    A Unlu
    Department of Biochemistry, School of Medicine, Mersin University, Zeytinlibahce Cad, 33079 Mersin, Turkey
    Pharmacol Res 48:11-5. 2003
    ..015). These overall results suggest that Daflon contributes renal protection from hind limb ischemia/reperfusion injury in some degree, by decreasing systemic oxidative stress...
  90. ncbi Flavonoids detection by HPLC-DAD-MS-MS in lemon juices from Sicilian cultivars
    Corrado Caristi
    Dipartimento di Chimica Organica e Biologica, Universita di Messina, Salita Sperone 31, 98166 S Agata di Messina, Italy
    J Agric Food Chem 51:3528-34. 2003
    ..were found in the lemon juice of the above-mentioned cultivars together with eriocitrin, hesperidin, and diosmin. Following purification by preparative HPLC, the structure was assigned as 6,8-di-C-glucopyranosyldiosmetin by ..
  91. ncbi Efficacy of Daflon in the treatment of hemorrhoids
    Abdul Wahed N Meshikhes
    Department of Surgery, Dammam Central Hospital, Qatif 31911, Kingdom of Saudi Arabia
    Saudi Med J 23:1496-8. 2002
    ..To demonstrate the value of Daflon in the management of hemorrhoidal symptoms in Saudi patients attending the Surgical clinic...
  92. ncbi A randomised controlled trial of micronised purified flavonoid fraction vs placebo in patients with chronic venous disease
    G Danielsson
    Section of Vascular Surgery, Department of Surgery, Lund University Hospital, Sweden
    Eur J Vasc Endovasc Surg 23:73-6. 2002
    ..to evaluate the efficacy of a micronised purified flavonoid fraction (MPFF) in the treatment of chronic venous disease (CVD)...
  93. ncbi HR (Venoruton1000, Paroven, 0-[beta-hydroxyethyl]-rutosides) vs. Daflon 500 in chronic venous disease and microangiopathy: an independent prospective, controlled, randomized trial
    G Belcaro
    Irvine2 Vascular Laboratory and Physiology, Department of Biomedical Sciences, Chieti University, San Valentino Vascular Screening Project, Italy
    J Cardiovasc Pharmacol Ther 7:139-45. 2002
    ..was to demonstrate whether and how HR (Venoruton(1000), Paroven, 0-[beta-hydroxyethyl]-rutosides) and Daflon (diosmin, 500 mg) were comparatively effective in improving the microcirculation in venous hypertension and microangiopathy...
  94. ncbi Anti-inflammatory actions of a micronized, purified flavonoid fraction in ischemia/reperfusion
    Ronald J Korthui
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, School of Medicine in Shreveport, 71130, USA
    Adv Exp Med Biol 505:181-90. 2002
    ..In addition, it appears that these compounds prevent the expression of specific adhesion molecules involved in leukocyte recruitment, observations which provide the molecular basis for the anti-adhesive properties of these compounds...
  95. ncbi Leukocyte adhesion after oxidant challenge in the hamster cheek pouch microcirculation
    E Bouskela
    Laboratório de Pesquisas em Microcirculação, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
    J Vasc Res 36:11-4. 1999
    Oral administration of S-5682 (Daflon 500 mg, 90% diosmin, 10% hesperidin) inhibits oxidant-induced increase in macromolecular permeability in the postcapillary venules of the hamster cheek pouch microcirculation...
  96. ncbi [Analysis of surgical procedures on the vena saphena magna in the Czech Republic and an effect of Detralex during its stripping]
    L Veverkova
    I Chirurgická klinika LF MU, FN u sv, Anny v Bmrn
    Rozhl Chir 84:410-2, 414-6. 2005
    ..High quality venoactive drugs administered 14 days prior to the surgery improve postoperative course in patients indicated for surgical treatment of varices...
  97. ncbi Effect of benzopyrone derivatives on simultaneously induced croton oil ear oedema and carrageenin paw oedema in rats
    M Gabor
    Department of Pharmacodynamics, Albert Szent Gyorgyi University Medical School, Hungary
    Acta Physiol Hung 77:197-207. 1991
    ..manner and to statistically significant degrees by lipoxygenase- and cyclooxygenase-blocker flavonoids (diosmin, fisetin, quercetin, myricetin, galangin, sophoricoside, hesperidin-methylchalcone, oligomeric procyanidin, ..
  98. ncbi Clinical and hemodynamic outcomes in patients with chronic venous insufficiency after oral micronized flavonoid therapy
    A C Ting
    Division of Vascular Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong, China
    Vasc Surg 35:443-7. 2001
    ..In this regard, Daflon would be especially useful for symptomatic relief in patients with functional venous insufficiency who do not have clinical evidence of varicose veins but suffer from symptoms of venous insufficiency...
  99. ncbi [Butcher's Broom, in the treatment of venous insufficiency]
    Wiesława Bylka
    Katedra i Zakład Farmakognozji Akademii Medycznej, Poznaniu
    Pol Merkur Lekarski 19:234-6. 2005
    ..their derivatives, acting on the venous system, including horse-chestnut seed extracts aescin, rutin, troxerutin, diosmin and hesperidine. They have a long tradition in herbal medicine for their venotonic and anti-oedematous properties...
  100. ncbi Flavonoids to reduce bleeding and pain after stapled hemorrhoidopexy: a randomized controlled trial
    Bostjan Mlakar
    Medical Centre IATROS, Ljubljana, Slovenia
    Wien Klin Wochenschr 117:558-60. 2005
    ..Phlebotropic activity, protective effect on the capillaries and anti-inflammatory properties of this drug have been reported in several studies...
  101. ncbi [Derivatives of semi-synthetic diosmine in the treatment of patients with chronic venous insufficiency. The results of a prospective study--using phlebodia 600]
    A V Pokrovskii
    Angiol Sosud Khir 11:73-9. 2005
    ..The authors analyze the reports concerning the use of the above-indicated drug in European phlebological practice...

Research Grants2

  1. DiosMemTM, a natural gamma-secretase inhibitor, opposes AD pathogenesis
    Jun Tan; Fiscal Year: 2009
    ..in vivo validation, we find that administration of luteolin and a glycoside of a structurally similar flavonoid, diosmin, to Tg2576 mice similarly reduces A[unreadable] generation potentially through GSK-3 inhibition...
  2. IL-6-mediated Jak2/Stat3 signaling and Brain Development
    Jun Tan; Fiscal Year: 2010
    ..As a validation of these findings, we next examined the effects of a STAT3 inhibitor (S31-201) and diosmin, a flavanoid structurally similar to luteolin, on JAK2/STAT3 signaling in vivo...