chromones

Summary

Top Publications

  1. ncbi Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
    L del Peso
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Science 278:687-9. 1997
  2. ncbi Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation
    J Brognard
    Developmental Therapeutics Department, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20889, USA
    Cancer Res 61:3986-97. 2001
  3. pmc Exploring the specificity of the PI3K family inhibitor LY294002
    Severine I Gharbi
    Ludwig Institute for Cancer Research, Proteomics Unit, Cruciform Building, Gower Street, London WCE1 6BT, UK
    Biochem J 404:15-21. 2007
  4. ncbi G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells
    Ning Gao
    1820 MBR Cancer Center and Dept of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 9300, USA
    Am J Physiol Cell Physiol 287:C281-91. 2004
  5. ncbi Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression
    Hsien Yeh Hsu
    Faculty of Medical Technology, Institute of Biotechnology in Medicine, National Yang Ming University, 112 Taipei, Taiwan
    J Biol Chem 277:22131-9. 2002
  6. ncbi A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia
    Elaine Willmore
    School of Cell and Molecular Biosciences, University of Newcastle upon Tyne Medical School, Newcastle upon Tyne NE2 4HH, United Kingdom
    Blood 103:4659-65. 2004
  7. ncbi The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation
    Wen Jie Cai
    Department of Physiology and Pathophysiology, Fudan University Shanghai Medical College, Shanghai, China
    Cardiovasc Res 76:29-40. 2007
  8. ncbi Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells
    Amy S Clark
    Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20889, USA
    Mol Cancer Ther 1:707-17. 2002
  9. ncbi Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase
    Lilian Amrein
    Montreal Centre for Experimental Therapeutics in Cancer Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    J Pharmacol Exp Ther 321:848-55. 2007
  10. ncbi Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells
    Noriyuki Ouchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 279:1304-9. 2004

Detail Information

Publications266 found, 100 shown here

  1. ncbi Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
    L del Peso
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Science 278:687-9. 1997
    ..Thus, the proapoptotic function of BAD is regulated by the PI 3-kinase-Akt pathway...
  2. ncbi Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation
    J Brognard
    Developmental Therapeutics Department, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20889, USA
    Cancer Res 61:3986-97. 2001
    ....
  3. pmc Exploring the specificity of the PI3K family inhibitor LY294002
    Severine I Gharbi
    Ludwig Institute for Cancer Research, Proteomics Unit, Cruciform Building, Gower Street, London WCE1 6BT, UK
    Biochem J 404:15-21. 2007
    ..The present study reveals that LY294002 not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family...
  4. ncbi G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells
    Ning Gao
    1820 MBR Cancer Center and Dept of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 9300, USA
    Am J Physiol Cell Physiol 287:C281-91. 2004
    ..These results indicate that PI3K mediates G(1) progression and cyclin expression through activation of an AKT/mTOR/p70S6K1 signaling pathway in the ovarian cancer cells...
  5. ncbi Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression
    Hsien Yeh Hsu
    Faculty of Medical Technology, Institute of Biotechnology in Medicine, National Yang Ming University, 112 Taipei, Taiwan
    J Biol Chem 277:22131-9. 2002
    ....
  6. ncbi A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia
    Elaine Willmore
    School of Cell and Molecular Biosciences, University of Newcastle upon Tyne Medical School, Newcastle upon Tyne NE2 4HH, United Kingdom
    Blood 103:4659-65. 2004
    ..A concentration-dependent increase in etoposide-induced DSB levels was increased by NU7026. The mechanism of NU7026 potentiation of topo II poisons involves inhibition of NHEJ and a G2/M checkpoint arrest...
  7. ncbi The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation
    Wen Jie Cai
    Department of Physiology and Pathophysiology, Fudan University Shanghai Medical College, Shanghai, China
    Cardiovasc Res 76:29-40. 2007
    ..Hydrogen sulfide (H(2)S) has been reported to be a gasotransmitter which regulates cardiovascular homeostasis. The present study aims to examine the hypothesis that hydrogen sulfide is able to promote angiogenesis...
  8. ncbi Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells
    Amy S Clark
    Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20889, USA
    Mol Cancer Ther 1:707-17. 2002
    ....
  9. ncbi Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase
    Lilian Amrein
    Montreal Centre for Experimental Therapeutics in Cancer Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    J Pharmacol Exp Ther 321:848-55. 2007
    ....
  10. ncbi Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells
    Noriyuki Ouchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 279:1304-9. 2004
    ..These data indicate that adiponectin can function to stimulate the new blood vessel growth by promoting cross-talk between AMP-activated protein kinase and Akt signaling within endothelial cells...
  11. ncbi Loss in oxidative stress tolerance with aging linked to reduced extracellular signal-regulated kinase and Akt kinase activities
    Shizuo Ikeyama
    Laboratory of Cellular and Molecular Biology, National Institute on Aging IRP, Baltimore, Maryland 21224, USA
    FASEB J 16:114-6. 2002
    ..Strategies aimed at boosting these host responses to acute oxidant injury could have significant anti-aging benefits...
  12. ncbi Mutant PIK3CA promotes cell growth and invasion of human cancer cells
    Yardena Samuels
    The Sidney Kimmel Comprehensive Cancer Center and The Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
    Cancer Cell 7:561-73. 2005
    ..Treatment with the PI3K inhibitor LY294002 abrogated PIK3CA signaling and preferentially inhibited growth of PIK3CA mutant cells. These data have important implications for therapy of cancers harboring PIK3CA alterations...
  13. ncbi Migrating glioma cells activate the PI3-K pathway and display decreased susceptibility to apoptosis
    Anna M Joy
    The Translational Genomics Research Institute, 400 North 5th Street, Suite 1600, Phoenix, AZ 85004, USA
    J Cell Sci 116:4409-17. 2003
    ..In addition, evidence indicates that treatment with migration inhibitors, while not affecting apoptosis-induction in migration-restricted cells, can sensitize migrating glioma cells to cytotoxic agents...
  14. ncbi Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002
    Anjali K Gupta
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int J Radiat Oncol Biol Phys 56:846-53. 2003
    ..Inhibition of PI3K by LY294002 can synergistically enhance radiation efficacy. This acts as a proof of principle that inhibition of the Ras to PI3K pathway could be useful clinically...
  15. ncbi Salmonella transforms follicle-associated epithelial cells into M cells to promote intestinal invasion
    Amin Tahoun
    The Roslin Institute and Royal School of Veterinary Studies, University of Edinburgh, Edinburgh EH25 9RG, UK
    Cell Host Microbe 12:645-56. 2012
    ..Thus, via the activity of a single secreted effector, S. Typhimurium transforms primed epithelial cells into M cells to promote host colonization and invasion...
  16. ncbi Activation of Akt/GSK-3beta signaling pathway is involved in intermedin(1-53) protection against myocardial apoptosis induced by ischemia/reperfusion
    Jun Qiu Song
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China
    Apoptosis 14:1299-307. 2009
    ..In conclusion, IMD(1-53) exerts cardioprotective effect against myocardial I/R injury through the activation of the Akt/GSK-3beta signaling pathway to inhibit mitochondria-mediated myocardial apoptosis...
  17. pmc ER-alpha36, a variant of ER-alpha, promotes tamoxifen agonist action in endometrial cancer cells via the MAPK/ERK and PI3K/Akt pathways
    Sheng Li Lin
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences and Graduate School, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 5:e9013. 2010
    ..ER-alpha36 lacks intrinsic transcription activity and mainly mediates nongenomic estrogen signaling. Here, we studied the role of nongenomic estrogen signaling pathways mediated by ER-alpha36 in tamoxifen resistance and agonist action...
  18. pmc Phase I pharmacokinetic and pharmacodynamic study of the pan-PI3K/mTORC vascular targeted pro-drug SF1126 in patients with advanced solid tumours and B-cell malignancies
    D Mahadevan
    University of Arizona Cancer Center, Tucson, AZ, USA
    Eur J Cancer 48:3319-27. 2012
    ..A first-in-human study evaluated safety, dose limiting toxicities (DLT), maximum tolerated dose (MTD), pharmacokinetics (PK), pharmacodynamics (PD) and efficacy of SF1126, in patients with advanced solid and B-cell malignancies...
  19. ncbi Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination
    Michele Tavecchio
    Northern Institute for Cancer Research, School of Medical Sciences, Newcastle University, Paul O Gorman Building, Framlington Place, NE2 4HH Newcastle upon Tyne, UK
    Cancer Chemother Pharmacol 69:155-64. 2012
    ..One promising target is DNA-PK, a pivotal kinase in double-strand break repair. The purpose of this study was to further characterise the activity of the DNA-PK inhibitor NU7441, giving some new insights into the biology of DNA-PK...
  20. ncbi Involvement of PI3K/Akt signaling in PTTH-stimulated ecdysteroidogenesis by prothoracic glands of the silkworm, Bombyx mori
    Shi Hong Gu
    Department of Zoology, National Museum of Natural Science, 1 Kuan Chien Road, Taichung 404, Taiwan, ROC
    Insect Biochem Mol Biol 41:197-202. 2011
    ..mori prothoracic glands between insulin and PTTH signaling, which may play a critical role in precisely regulated ecdysteroidogenesis during development...
  21. ncbi Application of response surface methodology to optimise ultrasonic-assisted extraction of four chromones in Radix Saposhnikoviae
    Wei Li
    College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, People s Republic of China
    Phytochem Anal 22:313-21. 2011
    ..b>Chromones are considered as one of the effective components...
  22. ncbi Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441
    Yan Zhao
    Northern Institute for Cancer Research, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Cancer Res 66:5354-62. 2006
    ..In conclusion, NU7441 shows sufficient proof of principle through in vitro and in vivo chemosensitization and radiosensitization to justify further development of DNA-PK inhibitors for clinical use...
  23. pmc t-DARPP regulates phosphatidylinositol-3-kinase-dependent cell growth in breast cancer
    Bhavatarini Vangamudi
    Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Mol Cancer 9:240. 2010
    ..In this study, we evaluated expression of t-DARPP in human primary breast tumors, and investigated the role of t-DARPP in regulating growth and proliferation in breast cancer cells...
  24. ncbi LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors
    Kirthan Shenoy
    Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
    Cancer Res 69:1941-50. 2009
    ..Our findings could have implications for the use of LY30 and similar compounds for enhancing the apoptotic sensitivity of neuroblastoma cells that often become refractory to chemotherapy...
  25. ncbi Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase
    M Hetman
    Toxicology Program, Department of Environmental Health, the Graduate Program in Neurobiology and Behavior, The Graduate Program in Molecular and Cell Biology, University of Washington, Seattle, Washington 98195 7234, USA
    J Biol Chem 274:22569-80. 1999
    ..Furthermore, the relative contribution of the ERK and PI 3-kinase pathways to neuronal survival may depend on the type of cellular injury...
  26. ncbi Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation
    Didier Bouscary
    Departement d Hematologie, Institut Cochin, Institut National de la Sante et de la Recherche Medicale U567, Centre National de la Recherche Scientifique, UMR 8104, Universite Rene Descartes, Paris, France
    Blood 101:3436-43. 2003
    ....
  27. ncbi Effect of estradiol on estrogen receptor-alpha gene expression and activity can be modulated by the ErbB2/PI 3-K/Akt pathway
    Gerald E Stoica
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington DC 20057, USA
    Oncogene 22:7998-8011. 2003
    ..This results in the activation of PI 3-K and Akt. Akt, in turn, may interact with nuclear ER-alpha, altering its expression and activity...
  28. ncbi FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2
    Walbert J Bakker
    Campbell Family Institute for Breast Cancer Research, University Health Network, Ontario Cancer Institute and Princess Margaret Hospital, Toronto, ON M5G 2C1, Canada
    Mol Cell 28:941-53. 2007
    ..Thus, by fine-tuning HIF1 activity, FOXO3a plays an important role in the survival response of normal and cancer cells in response to hypoxic stress...
  29. pmc Role of phosphatidylinositol 3' kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in dictyostelium
    S Funamoto
    Section of Cell and Developmental Biology and Center for Molecular Genetics, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Cell Biol 153:795-810. 2001
    ..We suggest that PKB and PhdA lie downstream from PI3K and control different downstream effector pathways that are essential for proper chemotaxis...
  30. ncbi Cytosolic action of thyroid hormone leads to induction of hypoxia-inducible factor-1alpha and glycolytic genes
    Lars C Moeller
    The University of Chicago, MC3090, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Mol Endocrinol 19:2955-63. 2005
    ....
  31. ncbi Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways
    Yeshi Hu
    Cardiovascular Biology Research Group, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Pflugers Arch 455:607-16. 2008
    ..In conclusion, K(ATP)/PKC/ERK1/2 and PI3K/Akt pathways contributed to SP-induced cardioprotection...
  32. pmc Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor
    S Wennström
    Imperial Cancer Research Fund, London WC2A 3PX, United Kingdom
    Mol Cell Biol 19:4279-88. 1999
    ....
  33. ncbi Substituted chromones as highly potent nontoxic inhibitors, specific for the breast cancer resistance protein
    Glaucio Valdameri
    Equipe Labellisée Ligue 2011, Institut de Biologie et Chimie des Proteines, BMSSI UMR 5086, CNRS Université Lyon 1, Lyon, France
    J Med Chem 55:966-70. 2012
    A series of 13 disubstituted chromones was synthesized. Two types of substituents, on each side of the scaffold, contributed to both the potency of ABCG2 inhibition and the cytotoxicity...
  34. pmc Intrathecal cannabilactone CB(2)R agonist, AM1710, controls pathological pain and restores basal cytokine levels
    Jenny L Wilkerson
    Department of Neurosciences, University of New Mexico, Albuquerque, NM 87131, USA
    Pain 153:1091-106. 2012
    ..Cannabilactone CB(2)R agonists are emerging as anti-inflammatory agents with pain therapeutic implications...
  35. ncbi PKB/AKT and ERK regulation of caspase-mediated apoptosis by methylseleninic acid in LNCaP prostate cancer cells
    Hongbo Hu
    The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Carcinogenesis 26:1374-81. 2005
    ..These findings support the differential involvement of these protein kinase pathways in regulating apoptosis induction by different forms of selenium...
  36. ncbi The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a specific inhibitor of phosphatidylinositol 3'-kinase, in human colon cancer cells
    Shuho Semba
    First Department of Pathology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Clin Cancer Res 8:1957-63. 2002
    ..We postulated that 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a PI3K inhibitor, should inactivate Akt/PKB, consequently inhibiting cell proliferation and inducing apoptosis in vitro and in vivo...
  37. pmc Involvement of estrogen receptor-β in farrerol inhibition of rat thoracic aorta vascular smooth muscle cell proliferation
    Qun yi Li
    The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
    Acta Pharmacol Sin 32:433-40. 2011
    ....
  38. ncbi LY294002 and LY303511 sensitize tumor cells to drug-induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3-kinase-Akt pathway
    Tze Wei Poh
    Department of Physiology, National University Medical Institute, Faculty of Medicine, National University of Singapore, Singapore, Singapore
    Cancer Res 65:6264-74. 2005
    ....
  39. ncbi Inhibition of the phosphatidylinositol 3-kinase/p70(S6)-kinase pathway induces B16 melanoma cell differentiation
    R Busca
    INSERM U385, Faculte de Medecine, 06107 Nice, Cedex 02, France
    J Biol Chem 271:31824-30. 1996
    ..Furthermore, we provide evidence which suggests that cAMP-induced melanogenesis and dendricity are, at least partially, mediated by the cAMP inhibition of the phosphatidylinositol 3-kinase/p70(S6)-kinase signaling pathway...
  40. ncbi Synthesis and function of 3-phosphorylated inositol lipids
    B Vanhaesebroeck
    Ludwig Institute for Cancer Research, Riding House Street, London W1W 7BS
    Annu Rev Biochem 70:535-602. 2001
    ..This field is now moving toward a genetic dissection of 3-phosphoinositide action in a variety of model organisms. Such approaches will reveal the true role of the 3-phosphoinositides at the organismal level in health and disease...
  41. ncbi Chromones and coumarins from the dried fructus of Cnidium monnieri
    Jianyu Zhao
    Center for Natural Products Research, Chengdu Institute of Biology of the Chinese Academy of Sciences, P R China
    Fitoterapia 82:767-71. 2011
    Chemical investigations on the ethanolic extract of the dried fructus of Cnidium monnieri offered three chromones and eight coumarins...
  42. ncbi Long-term safety study of iguratimod in patients with rheumatoid arthritis
    Masako Hara
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo 162 0054, Japan
    Mod Rheumatol 17:10-6. 2007
    ..The rate was 46.9% at week 28 and 41.0% at week 52. To use iguratimod safely for a long time, patients should be observed closely for adverse reactions such as increased hepatic enzymes...
  43. ncbi Efficacy and safety of iguratimod compared with placebo and salazosulfapyridine in active rheumatoid arthritis: a controlled, multicenter, double-blind, parallel-group study
    Masako Hara
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo 162 0054, Japan
    Mod Rheumatol 17:1-9. 2007
    ..The study results suggest that iguratimod could become a new option for the treatment of rheumatoid arthritis...
  44. ncbi Luteolin inhibits lipopolysaccharide actions on human gingival fibroblasts
    Gloria Gutiérrez-Venegas
    Laboratorio de Bioquímica de la División de Estudios de Posgrado de la Facultad de Odontología, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico, D F, Mexico
    Eur J Pharmacol 541:95-105. 2006
    ..We concluded that luteolin interferes with LPS signaling pathways, reducing activation of several mitogen-activated protein kinase family members, and inhibits inflammatory mediator expression...
  45. ncbi Involvement of the phosphoinositide 3-kinase/protein kinase B signaling pathway in insulin/IGF-I-induced chondrogenesis of the mouse embryonal carcinoma-derived cell line ATDC5
    K Hidaka
    Laboratory of Molecular and Cellular Biochemistry, Higashi-ku, 812-8582, Fukuoka, Japan
    Int J Biochem Cell Biol 33:1094-103. 2001
    ..This is the first report that demonstrates the involvement of phosphoinositide signaling in the induction of chondrogenesis from undifferentiated cells...
  46. ncbi Suppression of pro-metastasis phenotypes expression in malignant pleural mesothelioma by the PI3K inhibitor LY294002 or the MEK inhibitor UO126
    George W Cole
    Section of Thoracic Oncology, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Anticancer Res 26:809-21. 2006
    ....
  47. ncbi Respiratory syncytial virus inhibits apoptosis and induces NF-kappa B activity through a phosphatidylinositol 3-kinase-dependent pathway
    Karl W Thomas
    Department of Internal Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
    J Biol Chem 277:492-501. 2002
    ..Blockade of PI 3-K activation resulted in rapid, premature apoptosis and inhibition of RSV-stimulated NF-kappaB-dependent gene transcription...
  48. ncbi Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity
    Atmaram D Khanolkar
    Center for Drug Discovery, Northeastern University, 116 Mugar Hall, 360 Huntington Avenue, Boston, Massachusetts 02115 5000, USA
    J Med Chem 50:6493-500. 2007
    ..In vitro testing revealed that the novel compounds are CB2 agonists, while in vivo testing of cannabilactones 4b and 5 found them to possess potent peripheral analgesic activity...
  49. pmc TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells
    Vijay Ramakrishnan
    Division of Hematology and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Hematol 85:675-86. 2010
    ..Our results provide the rationale for clinical evaluation of TG101209 alone or in combination with PI3K/Akt inhibitors in MM...
  50. ncbi LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization
    T W Poh
    Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 2 Medical Drive, Singapore 117597, Singapore
    Cell Death Differ 14:1813-25. 2007
    ..These data provide a novel mechanism of action of this small molecule with the potential for use in TRAIL-resistant tumors...
  51. pmc Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats
    Elizabeth J Rahn
    Neuroscience and Behavior Program, Department of Psychology, University of Georgia, Athens, GA 30602 3013, USA
    J Pharmacol Exp Ther 327:584-91. 2008
    ..Our data suggest that cannabinoid CB(2) receptors may be important therapeutic targets for the treatment of chemotherapy-evoked neuropathy...
  52. ncbi The phosphatidylinositol 3-kinase/Akt pathway enhances Smad3-stimulated mesangial cell collagen I expression in response to transforming growth factor-beta1
    Constance E Runyan
    Department of Pediatrics, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 279:2632-9. 2004
    ..This cross-talk between the Smad and PI3K pathways likely contributes to TGF-beta1 induction of glomerular scarring...
  53. ncbi Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance
    R A Campbell
    Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    J Biol Chem 276:9817-24. 2001
    ..Taken together, these results define a molecular link between activation of the PI 3-kinase/AKT survival pathways, hormone-independent activation of ERalpha, and inhibition of tamoxifen-induced apoptotic regression...
  54. ncbi The PTEN tumor suppressor inhibits telomerase activity in endometrial cancer cells by decreasing hTERT mRNA levels
    Chunxiao Zhou
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, CB 7570, Chapel Hill, NC 27599, USA
    Gynecol Oncol 101:305-10. 2006
    ..Given that PTEN is often absent and telomerase is overexpressed by endometrial cancers, we hypothesize that PTEN signaling is important in telomerase regulation...
  55. ncbi Apoptosis of metastatic prostate cancer cells by a combination of cyclin-dependent kinase and AKT inhibitors
    Subhra Mohapatra
    Molecular Oncology Program, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Int J Biochem Cell Biol 41:595-602. 2009
    ..Collectively, our data show apoptosis of prostate cancer cells by a drug combination and identify Bax activation as a basis of cooperation...
  56. ncbi Comprehensive analysis of oncogenic effects of PIK3CA mutations in human mammary epithelial cells
    Haijun Zhang
    Breast Cancer Program, Karmanos Cancer Institute, Detroit, MI 48201, USA
    Breast Cancer Res Treat 112:217-27. 2008
    ....
  57. ncbi Toll-like receptor 4 mediates lipopolysaccharide-induced collagen secretion by phosphoinositide3-kinase-Akt pathway in fibroblasts during acute lung injury
    ZhengYu He
    Department of Anesthesiology, Ninth People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Recept Signal Transduct Res 29:119-25. 2009
    ..Therefore, we infer that besides pulmonary macrophage, lung fibroblasts are also important target cells directly influenced by LPS, which may play an important role in ALI and pulmonary interstitial fibrosis...
  58. ncbi Inhibition of phosphatidylinositol-3-kinase and mitogen-activated protein kinase kinase 1/2 prevents melanoma development and promotes melanoma regression in the transgenic TPRas mouse model
    Barbara Bedogni
    Division of Radiation and Cancer Biology, 269 Campus Drive, CCSR S 1230, Stanford 94305, CA, USA
    Mol Cancer Ther 5:3071-7. 2006
    ....
  59. pmc Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026
    B P Nutley
    Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, 15 Cotswold Road, Sutton SM2 5NG, UK
    Br J Cancer 93:1011-8. 2005
    ..The pharmacokinetic simulations performed predict that NU7026 will have to be administered four times per day at 100 mg kg(-1) i.p. in order to obtain the drug exposure required for radiosensitisation...
  60. ncbi Inhibition of phosphatidylinositol 3'-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models
    Limin Hu
    Center for Reproductive Sciences, University of California, San Francisco, San Francisco, California 94143 0556, USA
    Cancer Res 62:1087-92. 2002
    ..Our data suggest that a combination of a PI3k inhibitor and conventional chemotherapy may provide an effective approach to inhibiting tumor growth and ascites production in ovarian cancer with acceptable side effects...
  61. ncbi PI-3K/Akt and NF-kappaB/IkappaBalpha pathways are activated in Jurkat T cells in response to TRAIL treatment
    Giorgio Zauli
    Dipartimento di Morfologia Umana Normale, Universita di Trieste, Via Manzoni, Trieste, Italy
    J Cell Physiol 202:900-11. 2005
    ....
  62. ncbi Cafestol, a coffee-specific diterpene, induces apoptosis in renal carcinoma Caki cells through down-regulation of anti-apoptotic proteins and Akt phosphorylation
    Min Jung Choi
    Department of Immunology, School of Medicine, Keimyung University, 2800 Dalgubeoldaero, Dalseo Gu, Daegu 704 701, Republic of Korea
    Chem Biol Interact 190:102-8. 2011
    ..Taken together, our results show the activity of cafestol to modulate multiple components in apoptotic response of human renal Caki cells and a potential as a therapeutic agent for preventing cancers such as renal carcinoma...
  63. pmc Somatic mutation and gain of copy number of PIK3CA in human breast cancer
    Guojun Wu
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Breast Cancer Res 7:R609-16. 2005
    ..Even though PIK3CA amplification and somatic mutation have been reported previously in various kinds of human cancers, the genetic change in PIK3CA in human breast cancer has not been clearly identified...
  64. ncbi Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias
    S Zhao
    Section of Molecular Hematology and Therapy, Department of Blood and Marrow Transplantation, MD Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA
    Leukemia 18:267-75. 2004
    ..In conclusion, the data suggest that the inhibition of the PI3K/AKT signaling pathway restores apoptosis in AML and may be explored as a novel target for molecular therapeutics in AML...
  65. ncbi Nanoparticle-mediated targeting of phosphatidylinositol-3-kinase signaling inhibits angiogenesis
    Rania Harfouche
    Harvard MIT Division of Health Sciences and Technology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Angiogenesis 12:325-38. 2009
    ..The objective of this study was to engineer a PI3K inhibitor-loaded biodegradable nanoparticle and to evaluate its efficacy...
  66. ncbi Neurite growth promotion by nerve growth factor and insulin-like growth factor-1 in cultured adult sensory neurons: role of phosphoinositide 3-kinase and mitogen activated protein kinase
    K Kimpinski
    Division of Basic Medical Sciences, Memorial University of Newfoundland, St. John's, Newfoundland, Canada
    J Neurosci Res 63:486-99. 2001
    ..Activation of PI 3-kinase and SNT by both NGF and IGF-1 correlated with their effects on neurite growth. These results support the hypothesis that the PI 3-kinase pathway plays an important role in neuritogenesis...
  67. ncbi ErbB2-overexpressing human mammary carcinoma cells display an increased requirement for the phosphatidylinositol 3-kinase signaling pathway in anchorage-independent growth
    U Hermanto
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
    Oncogene 20:7551-62. 2001
    ....
  68. pmc Cisplatin and PI3kinase inhibition decrease invasion and migration of human ovarian carcinoma cells and regulate matrix-metalloproteinase expression
    Amer K Karam
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Cytoskeleton (Hoboken) 67:535-44. 2010
    ..Our data suggests that inhibition of ovarian cancer cell motility is mediated via down-regulation of activated MMP2, TIMP1 and TIMP2 expression under these treatment conditions...
  69. ncbi Activation of phosphatidylinositol 3-kinase is important for erythropoietin-induced erythropoiesis from CD34(+) hematopoietic progenitor cells
    June Helen Myklebust
    Department of Immunology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Exp Hematol 30:990-1000. 2002
    ..The aim of this was to examine the relative involvement of PI3K in the development of glycophorin A (GPA)(+) erythroid cells from normal hematopoietic progenitor cells...
  70. ncbi 2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-Dependent protein kinase (DNA-PK)
    Jonathan J Hollick
    Northern Institute for Cancer Research, School of Natural Sciences Chemistry, Bedson Building, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Bioorg Med Chem Lett 13:3083-6. 2003
    ..2-0.4 microM range...
  71. ncbi Phosphorylation and regulation of Raf by Akt (protein kinase B)
    S Zimmermann
    Institute of Medical Virology, University of Zurich, Gloriastrasse 30 32, CH 8028 Zurich, Switzerland
    Science 286:1741-4. 1999
    ..These observations provide a molecular basis for cross talk between two signaling pathways at the level of Raf and Akt...
  72. ncbi Synthesis, crystal structure and DNA-binding studies of the Ln(III) complex with 6-hydroxychromone-3-carbaldehyde benzoyl hydrazone
    Bao Dui Wang
    College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China
    J Inorg Biochem 101:1492-504. 2007
    ..The intrinsic binding constants of complexes 1 and 2, and L were (7.62+/-0.56)x10(6), (3.70+/-0.47)x10(6) and (2.41+/-0.46)x10(6)M(-1), respectively...
  73. pmc 1alpha,25-dihydroxyvitamin D(3)-induced myeloid cell differentiation is regulated by a vitamin D receptor-phosphatidylinositol 3-kinase signaling complex
    Z Hmama
    Department of Medicine, The University of British Columbia, Faculties of Medicine and Science, The Research Institute of the Vancouver Hospital and Health Sciences Center, Vancouver, British Columbia, Canada
    J Exp Med 190:1583-94. 1999
    ..These findings suggest that PI 3-kinase selectively regulates D(3)-induced monocyte differentiation, independent of any effects on p21...
  74. ncbi Phosphatidylinositol-3-kinase as a therapeutic target in melanoma
    Saadia A Aziz
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA
    Clin Cancer Res 15:3029-36. 2009
    ..We assessed expression of PI3K in melanomas and nevi, and studied associations between PI3K pathway members and in vitro response to a PI3K inhibitor, LY294002...
  75. ncbi Selective regulation of interleukin-10 production via Janus kinase pathway in murine conventional dendritic cells
    Noriyuki Hirata
    Division of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Kita ku, Sapporo, Japan
    Cell Immunol 258:9-17. 2009
    ..LY294002, a specific inhibitor of PI3K, markedly inhibited the DC production of IL-10. Thus, JAK-PI3K axis appeared to be responsible for the IL-10 production by DCs...
  76. ncbi Role of the phosphatidylinositol 3'-kinase-Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines
    Ami Takeda
    Division of Organ Pathology, Department of Microbiology and Pathology, Graduate School of Medicine, Tottori University, Yonago, Japan
    Pancreas 28:353-8. 2004
    ....
  77. ncbi Activation of telomerase by ionizing radiation: differential response to the inhibition of DNA double-strand break repair by abrogation of poly (ADP-ribosyl)ation, by LY294002, or by Wortmannin
    Dirk Neuhof
    Laboratory of Radiation Biology, Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 69:887-94. 2007
    ..In addition, the role of trans-dominant inhibition of poly(ADP-ribosyl)ation, which strongly reduces DSB rejoining, was assessed in comparison with 3-aminobenzamide...
  78. ncbi p27Kip1 is required for PTEN-induced G1 growth arrest
    A R Gottschalk
    Department of Radiation Oncology, University of California at San Francisco, 94143, USA
    Cancer Res 61:2105-11. 2001
    ..These results implicate p27Kip1 as a critical mediator of PTEN-induced G1 arrest...
  79. ncbi HB-EGF-induced VEGF production and eNOS activation depend on both PI3 kinase and MAP kinase in HaCaT cells
    Kozo Nakai
    Department of Dermatology, Kagawa University, Japan
    J Dermatol Sci 55:170-8. 2009
    ....
  80. ncbi Therapeutic targeting of multiple signaling pathways in malignant pleural mesothelioma
    Toru Mukohara
    Lowe Center for Thoracic Oncology, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Oncology 68:500-10. 2005
    ..Furthermore, combinations of growth factor and signal transduction inhibitors may be needed to inhibit the growth of the majority of MPM cell lines, and therefore patients with MPM...
  81. ncbi Pressurized liquid extraction followed by LC-ESI/MS for analysis of four chromones in Radix Saposhnikoviae
    Wei Li
    College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, P R China
    J Sep Sci 33:2881-7. 2010
    An efficient pressurized liquid extraction (PLE) technique was employed in extracting chromones from the roots of Saposhnikovia divaricata (Radix Saposhnikoviae). Chromones were quantified and analyzed by LC-ESI/MS...
  82. ncbi Two chromones from Peperomia vulcanica
    James A Mbah
    Department of Chemistry, Faculty of Science, University of Dschang, Box 67 Dschang, Cameroon
    Phytochemistry 60:799-801. 2002
    TWO CHROMONES: 5-hydroxy-2-(14'-(E)-nonadecenyl) chromone (1) and 5-hydroxy-2-[12'-(3",4"-methylenedioxyphenyl)dodecanyl] chromone (2), together with six known compounds have been isolated from Peperomia vulcanica Baker & C...
  83. ncbi Xanthones and oxepino[2, 3-b]chromones from three endophytic fungi
    Karsten Krohn
    Department Chemie, Universität Paderborn, Warburger Strasse 100, 33098 Paderborn, Germany
    Chemistry 15:12121-32. 2009
    ..Preliminary studies indicated that 1, 2, and enone 7 showed antibacterial, fungicidal, and algicidal properties...
  84. ncbi Phosphatidylinositol 3-kinase inhibition by LY294002 radiosensitizes human cervical cancer cell lines
    Christopher M Lee
    Department of Radiation Oncology, University of Utah School of Medicine and Huntsman Cancer Hospital, Salt Lake City, Utah, USA
    Clin Cancer Res 12:250-6. 2006
    ..We evaluated the radiosensitizing effect of PI3K inhibition by LY294002 on clonogenic survival, growth characteristics, and gene expression in cervical cancer cell lines (HeLa and CaSki)...
  85. ncbi Synthesis of 3-aminomethyl-2-aryl- 8-bromo-6-chlorochromones
    Erik A A Wallen
    Department of Chemistry, Medicinal Chemistry, Goteborg University, SE 412 96 Goteborg, Sweden
    Org Lett 9:389-91. 2007
    ..The Cbz-protected 3-aminomethyl-2-aryl-8-bromo-6-chlorochromones can, e.g., be used in the synthesis of chromone-based beta-turn peptidomimetics...
  86. ncbi Synthesis of a novel series of diphenolic chromone derivatives as inhibitors of NO production in LPS-activated RAW264.7 macrophages
    Guo Biao Liu
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
    Bioorg Med Chem 18:2864-71. 2010
    ..Furthermore, a computational analysis of physicochemical parameters revealed that the most of the compounds possessed drug-like properties...
  87. ncbi Synthesis of 2-alkyl-substituted chromone derivatives using microwave irradiation
    Maria Fridén-Saxin
    Department of Chemistry, Medicinal Chemistry, University of Gothenburg, SE 41296 Goteborg, Sweden
    J Org Chem 74:2755-9. 2009
    ..The 4-chromanones could be further converted into highly functionalized 2,3,6,8-tetrasubstituted chromones in which a 3-substituent (acetate, amine, or bromine) was introduced via straightforward chemical transformations...
  88. ncbi Phosphatidylinositol 3-kinase in cumulus cells is responsible for both suppression of spontaneous maturation and induction of gonadotropin-stimulated maturation of porcine oocytes
    M Shimada
    Laboratory of Animal Reproduction, Graduate School of Biosphere Science, Hiroshima University, Higashi Hiroshima, Hiroshima, 739 8528, Japan
    J Endocrinol 179:25-34. 2003
    ..Judging from these results, it is estimated that PI 3-kinase in cumulus cells is required for both the suppression of spontaneous meiotic resumption and the induction of gonadotropin-stimulated meiotic resumption...
  89. ncbi P2X7 nucleotide receptor is coupled to GSK-3 inhibition and neuroprotection in cerebellar granule neurons
    Felipe Ortega
    Departamento de Bioquimica y Biologia Molecular IV, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda Puerta de Hierro s n, Madrid 28040, Spain
    Neurotox Res 15:193-204. 2009
    ..These results reveal that P2X(7) receptor activation could provide a relevant survival route alternative to classical neurotrophic factors...
  90. ncbi Preparative separation of chromones in plant extract of Saposhnikovia divaricata by high-performance counter-current chromatography
    Yuge Gui
    The Central Laboratory, Changchun Normal University, China, Changchun, PR China
    J Sep Sci 34:520-6. 2011
    Four chromones, prim-O-glucosylcimifugin, 4'-O-β-D-glucosyl-5-O-methylvisamminol, cimifugin and sec-O-glucosylhamaudol, were isolated and purified from Saposhnikovia divaricata for the first time by high-performance counter-current ..
  91. ncbi Enhancement of the dissolution rate and gastrointestinal absorption of pranlukast as a model poorly water-soluble drug by grinding with gelatin
    Sumio Chono
    Department of Pharmaceutics, Hokkaido Pharmaceutical University, 7 1 Katsuraoka cho, Otaru city 047 0264, Japan
    Int J Pharm 347:71-8. 2008
    ..Grinding a poorly water-soluble drug with gelatin is a useful method of enhancing its gastrointestinal absorption...
  92. ncbi Subinhibitory concentrations of farrerol reduce α-toxin expression in Staphylococcus aureus
    Jiazhang Qiu
    Institute of Zoonoses, College of Animal Sciences and Veterinary Medicine, Jilin University, Changchun, China
    FEMS Microbiol Lett 315:129-33. 2011
    ..aureus. The results show that farrerol significantly decreased, in a dose-dependent manner, the production of α-toxin by both methicillin-sensitive S. aureus and methicillin-resistant S. aureus...
  93. ncbi The effect of an oral leukotriene antagonist, ONO-1078, on allergen-induced immediate bronchoconstriction in asthmatic subjects
    Y Taniguchi
    First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    J Allergy Clin Immunol 92:507-12. 1993
    ..0 10 minutes after the exposure. CONCLUSIONS: Therefore, we conclude that cysteinyl leukotrienes primarily mediate a later part of immediate airway obstruction after allergen exposure...
  94. ncbi Overexpression of interferon-gamma-inducible GTPase inhibits coxsackievirus B3-induced apoptosis through the activation of the phosphatidylinositol 3-kinase/Akt pathway and inhibition of viral replication
    Huifang M Zhang
    Department of Pathology and Laboratory Medicine, University of British Columbia MRL The iCAPTUR4E Centre, St Paul s Hospital, Vancouver, British Columbia V6Z 1Y6, Canada
    J Biol Chem 278:33011-9. 2003
    ....
  95. ncbi Synthesis of 2,3,6,8-tetrasubstituted chromone scaffolds
    Kristian Dahlén
    Department of Chemistry, Medicinal Chemistry, Goteborg University, SE 412 96 Goteborg, Sweden
    J Org Chem 71:6863-71. 2006
    ..The chromones are also interesting structural scaffolds, and they have for example been designed to be used as mimetics of ..
  96. ncbi New sesquiterpenes from Ferula ferulaeoides (Steud.) Korovin. VI. Isolation and identification of three new dihydrofuro[2,3-b]chromones
    Akito Nagatsu
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Chem Pharm Bull (Tokyo) 50:675-7. 2002
    ..The structures were established by comprehensive spectral analysis. The biosynthetic pathway leading to these 2-prenyl-dihydrofurochromone-type sesquiterpenoids is proposed based on their structures...
  97. ncbi In vivo pharmacologic profile of ONO-1078: a potent, selective and orally active peptide leukotriene (LT) antagonist
    N Nakagawa
    Minase Research Institute, Ono Pharmaceutical Co, Ltd, Osaka, Japan
    Jpn J Pharmacol 60:217-25. 1992
    ....
  98. pmc Pharmacological characterization of AM1710, a putative cannabinoid CB2 agonist from the cannabilactone class: antinociception without central nervous system side-effects
    Elizabeth J Rahn
    Program in Neuroscience, Biomedical and Health Sciences Institute, University of Georgia, Athens, GA, United States
    Pharmacol Biochem Behav 98:493-502. 2011
    ..The observed pattern of pharmacological specificity produced by AM1710 is consistent with limited blood brain barrier penetration of this compound and absence of CNS side-effects...
  99. ncbi Antitubercular chromones and flavonoids from Pisonia aculeata
    Ming Chun Wu
    Graduate Institute of Natural Products, Department of Biomedical Laboratory Science and Biotechnology, School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China
    J Nat Prod 74:976-82. 2011
    Three new chromones, pisonins A (1), B (2), and D (4), two new flavonoids, pisonivanone [(2S)-5,7,2'-trihydroxy-8-methylflavanone] (7) and pisonivanol [(2R,3R)-3,7-dihydroxy-5,6-dimethoxyflavanone] (8), one new isoflavonoid, pisonianone (..
  100. ncbi Pigment epithelium-derived factor inhibits advanced glycation end-product-induced angiogenesis and stimulates apoptosis in retinal endothelial cells
    Sardarpasha Sheikpranbabu
    Department of Biotechnology, Division of Molecular and Cellular Biology, Kalasalingam University, Anand Nagar, Krishnankoil, 626190, Tamil Nadu, India
    Life Sci 85:719-31. 2009
    ....
  101. ncbi A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity
    JOSEPH R GARLICH
    Semafore Pharmaceuticals, Indianapolis, Indiana, USA
    Cancer Res 68:206-15. 2008
    ..The results support SF1126 as a viable pan PI3K inhibitor for phase I clinical trials in cancer and provide support for a new paradigm, the application of pan PI3K inhibitory prodrugs for the treatment of cancer...

Research Grants63

  1. Synthesis of Medicinally Important Heterocycles
    RICHARD LAROCK; Fiscal Year: 2007
    ..indoles, benzoselenophenes, benzolactams, dihydropyrimidines, 2-furanones, 2-pyrrolinones, benzopyrans, chromones and heteroatom analogues, furans, thiophenes, pyrroles, oxazoles, isoxazoles, pyrazoles, pyridines, quinolines, ..
  2. Pilot-Scale Heterocyclic and Carbocyclic Libraries for High Throughout Screening
    RICHARD LAROCK; Fiscal Year: 2009
    ..electrophiles will be utilized to prepare libraries of medicinally interesting indoles, benzofurans, coumestans, chromones, benzothiophenes, benzoselenophenes, phthalides, isocoumarins, isochromenes, isoquinolines, quinolines, furans, ..
  3. ENDOCRINE DISRUPTING CHEMICALS AND AROMATASE
    Shiuan Chen; Fiscal Year: 2009
    ..The proposed studies will focus on 1014 phytochemicals (including chalcones, chromones, coumarins, flavanones, flavones and isoflavones) that would be purchased from Indofine Co (Somerville, New ..
  4. Radiosensitization with the HIV protease inhibior Nelfinavir in NSCLC
    Anjali Gupta; Fiscal Year: 2008
    ..Specific Aim 3. To investigate in vitro the molecular mechanisms by which NFV results in sensitization. [unreadable] [unreadable] [unreadable]..
  5. Dedifferentiation Following Renal Cell Injury
    Shougang Zhuang; Fiscal Year: 2009
    ..These studies will increase our knowledge of the mechanisms of RPTC dedifferentiation after injury and may contribute to the development of novel treatment for patients with ARF. ..
  6. Role of VEGF in Neonatal Pulmonary Hypertension
    Theresa Grover; Fiscal Year: 2008
    ..These studies will provide an integrated approach to the hypothesis, incorporating whole animal physiology coupled with molecular and cellular studies. ..
  7. Paraventricular Nucleus Signaling Mechanisms in Hypertension
    CARRIE NORTHCOTT; Fiscal Year: 2008
    ..In addition, due to the integrative nature of the PVN, these data will also provide a glimpse at the role of signaling in other physiological conditions, such as obesity. ..
  8. Charles R. Drew Student Scholar Program
    JAYDUTT VADGAMA; Fiscal Year: 2007
    ..Specific Aim 3: Increase the number of racial/ethnic minority and/or disadvantaged high school and undergraduate students who will pursue higher education in the biomedical sciences. ..
  9. Akt1 and erbB2 - New Molecular Targets for Hormone Resistance in Breast Cancer
    Adriana Stoica; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. Sgk1 in Na+ transport in fetal lung epithelia
    Christie Thomas; Fiscal Year: 2007
    ..abstract_text> ..
  11. Glutamate Signaling and Drug Abuse
    MOHAMMADHOSSEIN GHASEMZADEH; Fiscal Year: 2007
    ....
  12. Fatty Acid Synthase in Prostate Tumorigenesis
    BETH PFLUG; Fiscal Year: 2007
    ....
  13. Synaptic Plasticity in the BNST and Drug Dependence
    Walter Francesconi; Fiscal Year: 2006
    ....
  14. ROS and NO interaction in the PVN during hypertension?
    CARRIE NORTHCOTT; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  15. CNS Effects of Alcohol-Gene Expression
    Pietro Sanna; Fiscal Year: 2006
    ..abstract_text> ..
  16. ALTERED NEUTROPHIL APOPTOSIS /BRONCHOPULMONARY DYSPLASIA
    Barry Weinberger; Fiscal Year: 2006
    ..The identification of specific pathways mediating apoptosis that are altered in neonatal neutrophils may also suggest preventive therapeutic strategies. ..
  17. Lung Cancer Chemoprevention using Deguelin
    Ho Young Lee; Fiscal Year: 2008
    ..abstract_text> ..
  18. Human Hematopoietic Cell Transformation by BCR/ABL
    Ravi Bhatia; Fiscal Year: 2008
    ..These studies are expected to result in improved understanding of mechanisms critical for human progenitor transformation in CML and guide rational development of additional mechanism-based therapies. ..
  19. Blood Outgrowth Endothelial Cell Seeding of Heart Valve Leaflets
    Robert J Levy; Fiscal Year: 2010
    ..This proposal will investigate a novel approach for a heart valve replacement by studying a trileaflet polyurethane valve that is seeded with autologous blood outgrowth endothelial cells. ..
  20. IL-15, Body Compositition and Insulin Sensivity in Aging
    LeBris S Quinn; Fiscal Year: 2010
    ..abstract_text> ..
  21. Pathogenic Mechanism of Polycystic Kidney Disease
    Yumay Chen; Fiscal Year: 2010
    ..Our studies will provide novel insight into the molecular pathogenesis of PKD. They will help explain why cysts progress at different rates and how therapies to slow the progression of PKD can be designed rationally. ..
  22. tPA plus MMP inhibition for combination stroke therapy
    Eng H Lo; Fiscal Year: 2010
    ..abstract_text> ..
  23. Redox Signaling in Osteoblast Differentiation
    Nandini Ghosh Choudhury; Fiscal Year: 2009
    ..Understanding the signal transduction pathways of osteoblast differentiation may result in the development of therapeutic modalities for the human diseases where lack of bone formation is the pathology. ..
  24. Dietary supplementation with glucan enhances immune fn
    David Williams; Fiscal Year: 2002
    ..At the successful conclusion of this research e will have established what, if any, effect dietary supplementation with glucan has on modulating immunocompetence arid whether oral glucans will increase resistance to infectious diseases. ..
  25. Effect of Drugs on Myocardial Hypoxia
    Garrett Gross; Fiscal Year: 2009
    ..Information gained from these studies will hopefully lead to new therapies to treat patients with ischemic heart disease. ..
  26. Mechanisms of filopodia initiation and actin transport
    Gianluca Gallo; Fiscal Year: 2009
    ..We present studies aimed at determining the role of extra-cellular signals, signaling pathways, and microtubules in regulating the earliest events in filopodial initiation. ..
  27. Abnormalities in gene expression in therapy-related MDS
    Ravi Bhatia; Fiscal Year: 2008
    ..These studies may also allow identification of markers of susceptibility to t-MDS allowing early detection of patients at risk for this complication. ..
  28. Insulin Control of Fat Regulation and Exercise in Teens
    Kristen Nadeau; Fiscal Year: 2008
    ..The K-23 application will help me reach my long-term goal of being an independent investigator in the field of pediatric insulin resistance and type 2 diabetes. ..
  29. EFFECTS OF NITRIC OXIDE ON FETOPLACENTAL ANGIOGENESIS
    Jing Zheng; Fiscal Year: 2008
    ..An additional Specific Aim IV will use the HPME cell line to confirm the key observations made from OFPAE cells. These studies will glean important information on the mechanisms regulating placental angiogenesis. ..
  30. CELLULAR INTERACTIONS IN PULMONARY OXYGEN TOXICITY
    ANBUKILI CHETTY; Fiscal Year: 2006
    ..This mentored work will provide extensive education and technical experience in Molecular Biology and the development of a model of hyperoxic lung injury. ..
  31. Renal Epithelial Sodium Channels and Syntaxins
    Sunil Saxena; Fiscal Year: 2006
    ..Epitope mapping will be used to optimize the specificity of polyclonal antibodies, and anti-sense oligonucleotides will be used to modulate the level of endogenous proteins in the mpkCCDC14 line. ..
  32. ANALYSIS OF NOVEL PLECKSTRIN HOMOLOGY DOMAIN
    Edward Skolnik; Fiscal Year: 2001
    ..Spiel -/- cell and cell lines will be used to definitely confirm or refute essential roles for Spiel in mediating the functions identified in previous aims. ..
  33. Toll-Like Receptors in Bacterial Antigen Induced HIV-LTR
    Ozlem Equils; Fiscal Year: 2004
    ..abstract_text> ..
  34. CARDIOVASCULAR CALCIFICATION PATHOPHYSIOLOGY & TREATMENT
    Robert Levy; Fiscal Year: 2003
    ....
  35. Cellular Mechanisms of HIV-induced Cognitive Deficits
    Pietro Sanna; Fiscal Year: 2003
    ..Such an observation would support a crucial role for this viral product in the cognitive dysfunction of HIV-infected individuals. The results of the proposed study will advance the understanding of the pathogenesis of HAD. ..
  36. Metastasis Competent Genes in Lung Cancer
    Alan Lader; Fiscal Year: 2003
    ..Lader (the PI), Dr. Kwiatkowski, an expert in genetics and molecular biology, and are an expert in metastasis. ..
  37. REGULATION AND FUNCTION OF THE ALPHA SUBUNIT OF ENAC
    Christie Thomas; Fiscal Year: 2003
    ..The long-term objectives are to understand the regulation and function of ENaC in transepithelial Na+ transport. ..
  38. PRIMATE ENDOCRINE REGULATION IN THE PERINATAL PERIOD
    Robert Jaffe; Fiscal Year: 2003
    ....
  39. PROTEOMIC ANALYSIS OF HIPPOCAMPAL HYPOXIC VULNERABILITY
    Jon Klein; Fiscal Year: 2003
    ..These studies will characterize changes in protein expression and post-translational modifications that may have important implications for cell survival and/or adaption to intermittent and sustained hypoxia. ..
  40. Proteomic Analysis of Diabetic Nephropathy
    Jon Klein; Fiscal Year: 2003
    ..abstract_text> ..
  41. Regulation of Stress in Diabetic Cardiomyopathy
    Ping Wang; Fiscal Year: 2002
    ..These studies should generate novel information and facilitate further understanding of the molecular mechanisms of diabetic cardiomyopathy. ..
  42. FUNCTION OF THE STE 20 KINASE NIK IN DROSOPHILA
    Edward Skolnik; Fiscal Year: 2002
    ..NIK minus cell lines will be derived from these mice, and these cell lines will be used to determine which upstream signals are dependent upon NIK to activate the JNK MAP kinase pathway. ..
  43. Regulation of Fibrogenesis by the Dietary Flavonoids
    Dennis Ricupero; Fiscal Year: 2002
    ....
  44. PI3-kinase and mTOR in NO production by macrophages
    STEVE WEINSTEIN; Fiscal Year: 2002
    ..The activity of p70 S6 kinase will be perturbed with a transfected mutant p70 S6 kinase allele and the consequence of this manipulation on the synthesis of interferon-beta and NO will be determined. ..
  45. Molecular Cloning of the Wilms tumor Gene from 7p15-21
    Khalid Sossey Alaoui; Fiscal Year: 2004
    ..Understanding the nature of the genetic events which allow these cells to escape their normal growth regulation may also provide an opportunity for therapeutic intervention. ..
  46. Effects of Alcohol on the BNST-Cellular Neurobiology
    Pietro Sanna; Fiscal Year: 2005
    ..abstract_text> ..
  47. Recombinant Antibodies for Neonatal HSV Prophylaxis
    Pietro Sanna; Fiscal Year: 2005
    ....
  48. PI3K Signaling in Single Lymphocytes Analyzed by LMS
    David Fruman; Fiscal Year: 2005
    ..Our second aim is to apply this technology to address the role of the PI3K regulatory isoform p85alpha in activation of different downstream signaling molecules. ..
  49. PI-3 Kinase Therapy in Mouse Tumor Models
    Ramon Parsons; Fiscal Year: 2005
    ..This information in combination with accurate measurements of tumor progression with MRI imaging will allow us to identify potential mechanisms resulting in heterogeneous responses to therapy. ..
  50. GENETIC TRACING STRATEGIES FOR THE RAT NERVOUS SYSTEM
    Pietro Sanna; Fiscal Year: 2005
    ..The results of the present R21 will contribute to the development and refinement of strategies for the regulated delivery of recombinant tracers and, in follow-up studies, other reporters such as functional biosensors. ..
  51. Role of proteoglycans in cocaine dependence
    Pietro Sanna; Fiscal Year: 2004
    ..The elucidation of the neurobiological bases for the transition from non-dependent drug use to addiction is of crucial importance for the development of novel and more effective therapeutic approaches. ..
  52. Polyurethane Calcification:Mechanism and Inhibition
    Robert Levy; Fiscal Year: 2004
    ..abstract_text> ..
  53. BIOLOGY OF OVARIAN CANCER
    Robert Jaffe; Fiscal Year: 2005
    ..The projects will be subserved by three cores: Administration, Biometry and Tissue/Pathology. ..
  54. MYOCARDIAL CONTROLLED RELEASE IMPLANTS FOR ARRHYTHMIAS
    Robert Levy; Fiscal Year: 2001
    ..3) We will perform comparable therapeutic studies with a candidate RGT plasmid vector, HERG (A561V). ..
  55. DIETARY NUTRIENTS AS MODULATORS OF HEPATIC METABOLISM
    Michael Pagliassotti; Fiscal Year: 2001
    ..Finally, to explain the decreased Km of G-6Pase for G6P during HS diet, and increased Vmax during HF diet, kinetics of this enzyme will be measured in the intact and disrupted microsomes. ..
  56. Phosphoinositide 3-Kinase Function in Lymphocytes
    David Fruman; Fiscal Year: 2006
    ..Biochemical assays will be used to analyze signaling in purified T cells. These studies will increase our understanding of PI3K signaling, a central control point in lymphocyte proliferation. ..
  57. BRAIN CELL APOPTOSIS AFTER INTRACEREBRAL HEMORRHAGE
    ENG LO; Fiscal Year: 2003
    ..Results may be used to improve the clinical management and treatment of intracerebral hemorrhage. ..
  58. MATERNAL ALCOHOLISM AND CNS DEVELOPMENT IN OFFSPRING
    MARY DRUSE MANTEUFFEL; Fiscal Year: 2007
    ..Analyses will include western blot analyses, real-time quantitative RT-PCR, fluorescence and light microscopy, immunohistochemistry, and enzyme assays. ..
  59. The role of Gq in insulin resistant cardiac hypertrophy
    Patrick Yue; Fiscal Year: 2006
    ..Specific Aim 3: To study the effect of Gq ablation on the MAPK signaling cascade, a major pathway leading to hypertrophy. ..
  60. MECHANISMS OF HEMORRHAGE AND EDEMA IN TPA STROKE THERAPY
    ENG LO; Fiscal Year: 2006
    ..This proposal should fit the goals of the Stroke PRG because it examines novel mechanisms that link tPA, cell signaling, MMPs, and hemorrhagic transformation in the neurovascular unit. ..
  61. MATRIX METALLOPROTEINASE AND APOPTOSIS IN BRAIN TRAUMA
    ENG LO; Fiscal Year: 2004
    ..To date, there are not effective treatments for traumatic brain injury. Results from these proposed experiments will help identify MMP and upstream MAP kinase pathways as viable therapeutic targets for this devastating condition. ..
  62. Matrix metalloproteinase-9 mediated cell death in stroke
    ENG LO; Fiscal Year: 2009
    ..Our lab and others have established MMP-9 as a key extracellular protease that modifies neurovascular homeostasis. These proposed studies should help reveal the mechanisms of MMP-9 mediated cell death in stroke. ..