Genomes and Genes
Summary: A broad-spectrum excitatory amino acid antagonist used as a research tool.
Publications285 found, 100 shown here
- Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signalingBrett C Dinatale
Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pennsylvania 16803, USA
Toxicol Sci 115:89-97. 2010..We screened the metabolites of this pathway for their ability to activate the AHR; results revealed that kynurenic acid (KA) is an efficient agonist for the human AHR...
- Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegenerationDaniel Zwilling
Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA 94158, USA
Cell 145:863-74. 2011..and free radical formation have been correlated with decreased levels of the neuroprotective metabolite kynurenic acid. Here, we describe the synthesis and characterization of JM6, a small-molecule prodrug inhibitor of kynurenine ..
- The astrocyte-derived alpha7 nicotinic receptor antagonist kynurenic acid controls extracellular glutamate levels in the prefrontal cortexHui Qiu Wu
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
J Mol Neurosci 40:204-10. 2010..hypothesized that these impairments may be secondary to increased levels of the astrocyte-derived metabolite kynurenic acid (KYNA), which inhibits alpha7 nicotinic acetylcholine receptors (alpha7AChR) and may thereby reduce glutamate ..
- The commissure of the inferior colliculus shapes frequency response areas in rat: an in vivo study using reversible blockade with microinjection of kynurenic acidManuel S Malmierca
Laboratory for the Neurobiology of Hearing, Institute for Neuroscience of Castilla y León and Faculty of Medicine, University of Salamanca, Salamanca, Spain
Exp Brain Res 153:522-9. 2003..In this study, we injected the glutamate receptor blocker kynurenic acid into one IC while recording the frequency response areas (FRAs) of neurons in the other, to test the ..
- The kynurenic acid hypothesis of schizophreniaSophie Erhardt
Karolinska Institutet, Department of Physiology and Pharmacology, Stockholm, Sweden
Physiol Behav 92:203-9. 2007..b>Kynurenic acid is an endogenous glutamate antagonist with a preferential action at the glycine-site of the N-methyl-D-..
- On the antioxidant properties of kynurenic acid: free radical scavenging activity and inhibition of oxidative stressR Lugo-Huitrón
Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, S S A, México D F 14269, Mexico
Neurotoxicol Teratol 33:538-47. 2011b>Kynurenic acid (KYNA) is an endogenous metabolite of the kynurenine pathway for tryptophan degradation and an antagonist of both N-methyl-D-aspartate (NMDA) and alpha-7 nicotinic acetylcholine (α7nACh) receptors...
- Kynurenic acid: a metabolite with multiple actions and multiple targets in brain and peripheryFlavio Moroni
Dipartimento di Farmacologia, Universita degli Studi di Firenze, Florence, Italy
J Neural Transm 119:133-9. 2012It is usually assumed that kynurenic acid (KYNA) modifies neuronal function because it antagonizes the glycine site of the NMDA receptors and/or the neuronal cholinergic α7 nicotine receptors...
- Increased cortical kynurenate content in schizophreniaR Schwarcz
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
Biol Psychiatry 50:521-30. 2001..CONCLUSIONS: The data demonstrate an impairment of brain kynurenine pathway metabolism in schizophrenia, resulting in elevated kynurenate levels and suggesting a possible concomitant reduction in glutamate receptor function...
- Pharmacological manipulation of kynurenic acid: potential in the treatment of psychiatric disordersSophie Erhardt
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
CNS Drugs 23:91-101. 2009..quinolinic acid is an excitotoxic NMDA receptor agonist, 3-hydroxykynurenine is a free-radical generator and kynurenic acid (KYNA) is an antagonist at glutamate and nicotinic receptors...
- GPR35 is a functional receptor in rat dorsal root ganglion neuronsHiroyuki Ohshiro
Pfizer Global Research and Development, Discovery Biology Research, 5 2 Taketoyo, Aichi 470 2393, Japan
Biochem Biophys Res Commun 365:344-8. 2008GPR35, previously an orphan G-protein coupled receptor, is a receptor for kynurenic acid. Here we examine the distribution of GPR35 in the rat dorsal root ganglion (DRG) and the effects of its selective activation...
- Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding coreHiroyasu Furukawa
Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY 10032, USA
EMBO J 22:2873-85. 2003..In addition, the NR1 S1S2 structure reveals the fold and interactions of loop 1, a cysteine-rich region implicated in intersubunit allostery...
- The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's diseaseSusanna Campesan
Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
Curr Biol 21:961-6. 2011..inhibition of kynurenine 3-monooxygenase (KMO) increases levels of the neuroprotective metabolite kynurenic acid (KYNA) relative to the neurotoxic metabolite 3-hydroxykynurenine (3-HK) and ameliorates neurodegeneration...
- Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptomsJörg C Schefold
Department of Nephrology and Intensive Care, Charite University Medicine, Campus Virchow Clinic, Berlin, Germany
Nephrol Dial Transplant 24:1901-8. 2009..Here we investigate Trp catabolism, IDO activity and the role of inflammation in moderate to very severe CKD and haemodialysis...
- Electrophysiological characterisation of the actions of kynurenic acid at ligand-gated ion channelsM H Selina Mok
Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Harlow, Essex CM19 5AW, United Kingdom
Neuropharmacology 57:242-9. 2009To better understand the effects of the tryptophan metabolite kynurenic acid (kynA) in the brain, we characterised its actions at five ligand-gated ion channels: NMDA, AMPA, GABA(A), glycine and alpha7 nicotinic acetylcholine receptors...
- G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinastCristina Cosi
Dipartimento di Farmacologia, Universita degli Studi di Firenze, Firenze, Italy
Neuropharmacology 60:1227-31. 2011G-protein coupled receptor 35 (GPR35) is a former "orphan receptor" expressed in brain and activated by either kynurenic acid or zaprinast...
- Presynaptic kynurenate-sensitive receptors inhibit glutamate releaseR Carpenedo
Department of Preclinical and Clinical Pharmacology, Viale Pieraccini 6, University of Florence, 50139 Florence, Italy
Eur J Neurosci 13:2141-7. 2001b>Kynurenic acid is a tryptophan metabolite provided with antagonist activity on ionotropic glutamate and alpha7 nicotinic acetylcholine receptors...
- Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophreniaS Erhardt
Department of Physiology and Pharmacology, Karolinska Institute, 171 77 Stockholm, Sweden
Neurosci Lett 313:96-8. 2001b>Kynurenic acid is an endogenous glutamate antagonist with a preferential action at the glycine-site of the N-methyl D-aspartate-receptor...
- Kynurenic acid influences the respiratory parameters of rat heart mitochondriaH Baran
Institute of Pharmacology and Toxicology, Veterinary University Vienna, Austria
Pharmacology 62:119-23. 2001In the present study the effect of L-kynurenine, kynurenic acid and quinolinic acid on the heart mitochondrial function were investigated...
- Interaction and transport of kynurenic acid via human organic anion transporters hOAT1 and hOAT3Yuichi Uwai
Laboratory of Clinical Pharmacodynamics, School of Pharmacy, Aichi Gakuin University, 1 100 Kusumoto cho, Chikusa ku, Nagoya shi, Japan
Pharmacol Res 65:254-60. 2012b>Kynurenic acid, a catabolite of tryptophan, is suggested to be involved in schizophrenia, and is known to be a uremic toxin, although there is little information about the mechanism of its disposition...
- An expanding range of targets for kynurenine metabolites of tryptophanTrevor W Stone
Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
Trends Pharmacol Sci 34:136-43. 2013..b>Kynurenic acid blocks NMDARs and α7-homomeric nicotinic cholinoceptors and is also an agonist at the orphan G-protein-..
- Hyperglycemia enhances the inhibitory effect of mitochondrial toxins and D,L-homocysteine on the brain production of kynurenic acidIwona Chmiel-Perzyńska
Family Medicine Department, Skubiszewski Medical University of Lublin, Staszica 13, PL 20 081 Lublin, Poland
Pharmacol Rep 59:268-73. 2007We have evaluated the effect of diabetes-mimicking conditions on the inhibition of kynurenic acid (KYNA) production exerted by mitochondrial toxins: 3-nitropropionic acid (3-NPA) and aminooxyacetic acid (AOAA), by endogenous agonists of ..
- The BTBR mouse model of autism spectrum disorders has learning and attentional impairments and alterations in acetylcholine and kynurenic acid in prefrontal cortexStephanie M McTighe
Neuroscience Research Unit, Pfizer Global Research and Development, Cambridge, Massachusetts, United States of America
PLoS ONE 8:e62189. 2013..accuracy in detecting short stimuli, lower basal levels of extracellular acetylcholine and higher levels of kynurenic acid within the prefrontal cortex...
- Cerebrospinal fluid kynurenic acid is associated with manic and psychotic features in patients with bipolar I disorderSara K Olsson
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Bipolar Disord 14:719-26. 2012b>Kynurenic acid (KYNA), an end metabolite of tryptophan degradation, antagonizes glutamatergic and cholinergic receptors in the brain...
- Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in parkinsonian monkeysLaurent Gregoire
Molecular Endocrinology and Oncology Research Center, CHUQ, CHUL Pavillon and Faculty of Pharmacy, Laval University, Quebec, PQ, Canada
Behav Brain Res 186:161-7. 2008..This was tested pharmacologically in MPTP monkeys by increasing the formation of kynurenic acid (KYNA), a tryptophan metabolite that inhibits glutamate release and also blocks NMDA receptors directly...
- Toxoplasma gondii and schizophrenia: linkage through astrocyte-derived kynurenic acid?Robert Schwarcz
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Schizophr Bull 33:652-3. 2007
- Kynurenic acid inhibits intestinal hypermotility and xanthine oxidase activity during experimental colon obstruction in dogsJ Kaszaki
Institute of Surgical Research, Szent Györgyi Albert Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary
Neurogastroenterol Motil 20:53-62. 2008b>Kynurenic acid (KynA), an endogenous antagonist of N-methyl-d-aspartate (NMDA) glutamate receptors, protects the central nervous system in excitotoxic neurological diseases...
- Age dependency of inhibition of alpha7 nicotinic receptors and tonically active N-methyl-D-aspartate receptors by endogenously produced kynurenic acid in the brainManickavasagom Alkondon
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, 10 S Pine St, Baltimore, MD 21201, USA
J Pharmacol Exp Ther 337:572-82. 2011In the mouse hippocampus normal levels of kynurenic acid (KYNA), a neuroactive metabolite synthesized in astrocytes primarily by kynurenine aminotransferase II (KAT II)-catalyzed transamination of L-kynurenine, maintain a degree of tonic ..
- Presence of kynurenic acid in food and honeybee productsMichal P Turski
Department of Toxicology, Institute of Agricultural Medicine, Jaczewskiego 2, 20 950, Lublin, Poland
Amino Acids 36:75-80. 2009b>Kynurenic acid (KYNA) is an endogenous antagonist of ionotropic glutamate receptors and the alpha 7 nicotinic acetylcholine receptor, showing anticonvulsant and neuroprotective activity...
- Time course of changes in the concentration of kynurenic acid in the brain of pentylenetetrazol-kindled ratsPiotr Maciejak
Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 26 28 Krakowskie Przedmiescie Street, 00 927 Warsaw, Poland
Brain Res Bull 78:299-305. 2009The time response of changes in the brain concentration of kynurenic acid (KYNA) was examined in rats subjected to the pentylenetetrazol (PTZ)-induced kindling of seizures (n=32)...
- Kynurenic acid inhibits circulatory responses to intracisternally injected L-proline in conscious ratsY Takemoto
Department of Physiology II, Hiroshima University Faculty of Medicine, Japan
Neurosci Lett 261:121-3. 1999..Prior injection of kynurenic acid (0...
- Kynurenic acid and schizophreniaSophie Erhardt
Dept of Physiology and Pharmacology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Adv Exp Med Biol 527:155-65. 2003..Thus, schizophrenia may be regarded as a glutamate deficiency disorder. Kynurenic acid (KYNA) is an endogenous glutamate antagonist with a preferential action at the glycinesite of the N-methyl D-..
- l-kynurenine combined with probenecid and the novel synthetic kynurenic acid derivative attenuate nitroglycerin-induced nNOS in the rat caudal trigeminal nucleusEniko Vamos
Department of Neurology, University of Szeged, Szeged, Hungary
Neuropharmacology 57:425-9. 2009..b>Kynurenic acid (KYNA) and its analogues may exert modulatory effects in many neuropathological conditions, probably via N-..
- Elevated levels of kynurenic acid in the cerebrospinal fluid of male patients with schizophreniaL K Nilsson
Department of Physiology and Pharmacology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Schizophr Res 80:315-22. 2005Previous studies have shown that endogenous brain levels of kynurenic acid (KYNA), a glutamate receptor antagonist, are elevated in patients with schizophrenia...
- The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implicationsC Hilmas
Department of Pharmacology and Experimental Therapeutics and Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Neurosci 21:7463-73. 2001The tryptophan metabolite kynurenic acid (KYNA) has long been recognized as an NMDA receptor antagonist. Here, interactions between KYNA and the nicotinic system in the brain were investigated using the patch-clamp technique and HPLC...
- Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytesPhilip E Chen
Centre for Neuroscience Research, Hugh Robson Building, University of Edinburgh, George Square, Edinburgh, UK
J Physiol 586:227-45. 2008....
- Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35Jinghong Wang
Amgen Inc, South San Francisco, California 94080, USA
J Biol Chem 281:22021-8. 2006..previously orphan G protein-coupled receptor, functions as a receptor for the kynurenine pathway intermediate kynurenic acid. Kynurenic acid elicits calcium mobilization and inositol phosphate production in a GPR35-dependent manner in ..
- Kynurenines in chronic neurodegenerative disorders: future therapeutic strategiesD Zadori
Department of Neurology, Albert Szent Gyorgyi Clinical Centre, University of Szeged, Szeged, Hungary
J Neural Transm 116:1403-9. 2009..considerations, possibilities that come into account include increasing the neuroprotective effect of kynurenic acid, or decreasing the levels of neurotoxic 3-hydroxy-L-kynurenine and quinolinic acid...
- Nanomolar concentrations of kynurenic acid reduce extracellular dopamine levels in the striatumArash Rassoulpour
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21218, USA
J Neurochem 93:762-5. 2005..We report here that nanomolar concentrations of the astrocyte-derived neuroinhibitory metabolite kynurenic acid (KYNA) potently reduce the extracellular levels of striatal dopamine in unanesthetized rats in vivo...
- Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunitiesRobert Schwarcz
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, USA
J Pharmacol Exp Ther 303:1-10. 2002..NMDA) receptor agonist quinolinic acid, and the NMDA and alpha7 nicotinic acetylcholine receptor antagonist kynurenic acid. The ambient levels of these compounds are determined by several KP enzymes, which in the brain are ..
- N-Methyl-D-aspartate receptor antagonism decreases motility and inflammatory activation in the early phase of acute experimental colitis in the ratG Varga
Institute of Surgical Research, Szent Györgyi Albert Medical and Pharmaceutical Centre, University of Szeged, Szeged, Hungary
Neurogastroenterol Motil 22:217-25, e68. 2010....
- Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behaviorMichelle C Potter
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Neuropsychopharmacology 35:1734-42. 2010At endogenous brain concentrations, the astrocyte-derived metabolite kynurenic acid (KYNA) antagonizes the alpha 7 nicotinic acetylcholine receptor and, possibly, the glycine co-agonist site of the NMDA receptor...
- Neuropharmacology of quinolinic and kynurenic acidsT W Stone
Department of Pharmacology, University of Glasgow, Scotland
Pharmacol Rev 45:309-79. 1993..The pathway includes two compounds, quinolinic acid and kynurenic acid, which are remarkably specific in their pharmacological profiles: one is a selective agonist at receptors ..
- Kynurenic acid in human saliva--does it influence oral microflora?Damian Kuc
Department of Clinical and Experimental Pharmacology, Medical University, Jaczewskiego 8, PL 20 090 Lublin, Poland
Pharmacol Rep 58:393-8. 2006b>Kynurenic acid (KYNA) is an endogenous antagonist of alpha7 nicotinic receptors and all ionotropic glutamate receptors. Its neuroprotective activity has been suggested...
- Kynurenic acid synthesis and kynurenine aminotransferases expression in colon derived normal and cancer cellsKatarzyna Walczak
Department of Medical Biology, Institute of Agricultural Medicine, Lublin, Poland
Scand J Gastroenterol 46:903-12. 2011b>Kynurenic acid (KYNA), a tryptophan metabolite, was found in human saliva, gastric juice, bile, pancreatic juice and mucus of rat small intestine.
- Kynurenic acid has a dual action on AMPA receptor responsesChristina Prescott
Department of Neurology and Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Neurosci Lett 402:108-12. 2006..Here we demonstrate that kynurenic acid (KYNA), an endogenous tryptophan metabolite, acts upon heterologous AMPA receptors via two distinct mechanisms...
- Competitive antagonism between the nicotinic allosteric potentiating ligand galantamine and kynurenic acid at alpha7* nicotinic receptorsCristiane Lopes
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Pharmacol Exp Ther 322:48-58. 2007Galantamine, a drug used to treat Alzheimer's disease, is a nicotinic allosteric potentiating ligand, and kynurenic acid (KYNA), a neuroactive metabolite of the kynurenine pathway, is an endogenous noncompetitive inhibitor of alpha7* ..
- Determination of kynurenic acid in human serum and its correlation with the concentration of certain amino acidsTakeshi Fukushima
Division of Bio Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka, Shizuoka 422 8526, Japan
Clin Chim Acta 377:174-8. 2007b>Kynurenic acid (KYNA)--a tryptophan metabolite--elicits antagonistic activity against glutaminergic and cholinergic receptors; it has been suggested to have some relationship with neurological disorders...
- L-cysteine sulphinate, endogenous sulphur-containing amino acid, inhibits rat brain kynurenic acid production via selective interference with kynurenine aminotransferase IITomasz Kocki
Department of Pharmacology and Toxicology, Medical University, Jaczewskiego 8, 20 090 Lublin, Poland
Neurosci Lett 346:97-100. 2003..L-cysteate, L-homocysteine sulphinate and L-homocysteate, on the production of glutamate receptor antagonist, kynurenic acid (KYNA), was evaluated. The experiments comprised the measurements of (a)...
- IDO and interferon-alpha-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicityM C Wichers
Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
Mol Psychiatry 10:538-44. 2005..Measurements of TRP, amino acids competing with TRP for entrance through the blood-brain barrier, KYN and kynurenic acid (KA), a neuroprotective metabolite, were performed using high-performance liquid chromatography...
- Serum kynurenic acid positively correlates with cardiovascular disease risk factor, homocysteine: a study in stroke patientsEwa M Urbanska
Department of Pharmacology and Toxicology, Skubiszewski Medical University in Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
Pharmacol Rep 58:507-11. 2006..001; r = 0.6401), and with urea level (p = 0.017; r = 0.4813). Clinical significance of the association between serum KYNA and homocysteine levels requires further investigation...
- Induction of the kynurenine pathway by neurotropic influenza A virus infectionMaria Holtze
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
J Neurosci Res 86:3674-83. 2008..b>Kynurenic acid, an end product of tryptophan degradation along the kynurenine pathway, is an endogenous NMDA receptor ..
- Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice culturesRaffaella Carpenedo
Dipartimento di Farmacologia Preclinica e Clinica, Universita di Firenze, Firenze, Italy
J Neurochem 82:1465-71. 2002..3-HK) and quinolinic acid (QUIN) neosynthesis and facilitate kynurenine metabolism towards kynurenic acid (KYNA) formation...
- Synergistic effect of the L-tryptophan and kynurenic acid with dipyrone or paracetamol in miceNayrton Flávio Moura Rocha
Department of Physiology and Pharmacology, Universidade Federal do Ceara, CEP 60430 270, Brazil
Chem Biol Interact 205:148-56. 2013Our great interest in this work was study the synergism between l-tryptophan and dipyrone or paracetamol as well as the interaction of kynurenic acid (l-tryptophan metabolite) and these analgesics agents utilizing a robust methodology.
- Endothelium-dependent production and liberation of kynurenic acid by rat aortic rings exposed to L-kynurenineJanusz Stazka
Department of Cardiosurgery, Medical University, Jaczewskiego 8, 20 090 Lublin, Poland
Eur J Pharmacol 448:133-7. 2002Rat aortic slices produced and liberated the endogenous antagonist of glutamate receptors, kynurenic acid, upon exposure to L-kynurenine...
- GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapsesRolando Berlinguer-Palmini
Department of Neuroscience, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology, University of Florence, Florence, Italy
PLoS ONE 8:e82180. 2013..Limited information is available on the brain expression and role of GPR35, a Gi/o coupled receptor activated by kynurenic acid (KYNA). In mouse cultured astrocytes, we detected GPR35 transcript using RT-PCR and we found that KYNA (0...
- Regulation of kynurenic acid synthesis in C6 glioma cellsTomasz Kocki
Department of Pharmacology and Toxicology, Medical University, Lublin, Poland
J Neurosci Res 68:622-6. 2002Studies with brain slices have provided evidence that synthesis of kynurenic acid (KYNA) from kynurenine (KYN), which occurs in astrocytes, is modulated by changes in the ionic composition of the medium and the presence of depolarizing ..
- Kynurenic acid enhances expression of p21 Waf1/Cip1 in colon cancer HT-29 cellsKatarzyna Walczak
Department of Medical Biology, Institute of Rural Health, Jaczewskiego 2, PL 20 950 Lublin, Poland
Pharmacol Rep 64:745-50. 2012b>Kynurenic acid (KYNA), a tryptophan metabolite, was found in the mucus of rat small intestine. However, its role in the gastrointestinal tract is still not fully elucidated.
- Cortical kynurenic acid bi-directionally modulates prefrontal glutamate levels as assessed by microdialysis and rapid electrochemistryA Konradsson-Geuken
Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
Neuroscience 169:1848-59. 2010..this study examined the modulation of extracellular glutamate levels by endogenously produced kynurenic acid (KYNA) in the prefrontal cortex (PFC) of awake rats. Measured by microdialysis, i.p...
- Kynurenic acid in human renal cell carcinoma: its antiproliferative and antimigrative action on Caki-2 cellsKatarzyna Walczak
Department of Medical Biology, Institute of Agricultural Medicine, Jaczewskiego 2, 20 950, Lublin, Poland
Amino Acids 43:1663-70. 2012..Taking into account a considerably high concentration of one of the tryptophan metabolites, kynurenic acid (KYNA) in this organ and previously reported antiproliferative activity against colon cancer cells in vitro, ..
- Stacking interaction and its role in kynurenic acid binding to glutamate ionotropic receptorsAlexander V Zhuravlev
Pavlov Institute of Physiology, Russian Academy of Science, St Petersburg, Russia
J Mol Model 18:1755-66. 2012..with glutamate ionotropic receptors (iGluRs), in particular, the complex of NMDA receptor NR1 subunit with the kynurenic acid (KYNA) derivatives...
- Increased levels of kynurenine and kynurenic acid in the CSF of patients with schizophreniaKlas R Linderholm
Department of Physiology and Pharmacology, Nanna Svartz vag 2, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Schizophr Bull 38:426-32. 2012The kynurenic acid (KYNA) hypothesis for schizophrenia is partly based on studies showing increased brain levels of KYNA in patients...
- The neuroprotector kynurenic acid increases neuronal cell survival through neprilysin inductionChristian Klein
Biopathologie de Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Universite de Strasbourg, Faculte de Medecine, 11 rue Humann, 67000 Strasbourg, France
Neuropharmacology 70:254-60. 2013b>Kynurenic acid (KYNA), one of the main product of the kynurenine pathway originating from tryptophan, is considered to be neuroprotective...
- Kynurenic acid inhibits glutamatergic transmission to CA1 pyramidal neurons via α7 nAChR-dependent and -independent mechanismsJyotirmoy Banerjee
Division of Translational Toxicology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Biochem Pharmacol 84:1078-87. 2012Glutamatergic hypofunction and elevated levels of kynurenic acid (KYNA) in the brain are common features of patients with schizophrenia...
- Different inhibitory effects of kynurenic acid and a novel kynurenic acid analogue on tumour necrosis factor-α (TNF-α) production by mononuclear cells, HMGB1 production by monocytes and HNP1-3 secretion by neutrophilsZoltán Tiszlavicz
Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary
Naunyn Schmiedebergs Arch Pharmacol 383:447-55. 2011b>Kynurenic acid (KynA), a broad spectrum antagonist of excitatory amino acid receptors, may serve as a protective agent in neurological disorders...
- Kynurenic acid in synovial fluid and serum of patients with rheumatoid arthritis, spondyloarthropathy, and osteoarthritisJolanta Parada-Turska
Department of Rheumatology and Connective Tissue Diseases, Medical University, Lublin, Poland
J Rheumatol 40:903-9. 2013Previously we demonstrated that kynurenic acid (KYNA), an endogenous metabolite of kynurenine, is present in the synovial fluid of patients with rheumatoid arthritis (RA). KYNA inhibits proliferation of synoviocytes in vitro...
- Relationship of neurologic status in macaques infected with the simian immunodeficiency virus to cerebrospinal fluid quinolinic acid and kynurenic acidM P Heyes
Section of Analytical Biochemistry, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892
Brain Res 570:237-50. 1992..Increases in serum QUIN and CSF kynurenic acid also occurred but generally to a lesser degree than the increases in CSF QUIN...
- Kynurenic acid in plasma and endometrium in bitches with pyometraRoman Dabrowski
Department and Clinic of Animal Reproduction, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Głeboka 30, 20 612, Lublin, Poland
Inflammation 36:131-5. 2013b>Kynurenic acid (KYNA) is produced enzymatically in humans and animals from kynurenine. Reports concerning changes of kynurenine metabolism during inflammation are available in the literature...
- Plasma kynurenic acid/tryptophan ratio: a sensitive and reliable biomarker for the assessment of renal functionJianxing Zhao
Shanghai Key Laboratory of Vascular Biology, Ruijin Hospital and Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Ren Fail 35:648-53. 2013Decreased tryptophan (TRP) and increased kynurenine (KYN) and kynurenic acid (KYNA) in blood have been reported in patients and experimental animals with renal diseases...
- Kynurenic acid in honey from arboreal plants: MS and NMR evidenceGiangiacomo Beretta
Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Faculty of Pharmacy, University of Milan, Milan, Italy
Planta Med 73:1592-5. 2007..Moreover, kynureninates, owing to their antimicrobial properties, can favour the successful outcome of wounds and burns...
- Micromolar concentration of kynurenic acid in rat small intestineD Kuc
Department of Experimental and Clinical Pharmacology, Medical University, Lublin, Poland
Amino Acids 35:503-5. 2008b>Kynurenic acid is an antagonist of glutamate and alpha-7 nicotinic acetylcholine receptors and an agonist of the G: -protein-coupled receptor GPR35, which is predominantly expressed in immune and gastrointestinal tissues...
- Pharmacologically elevated levels of endogenous kynurenic acid prevent nicotine-induced activation of nigral dopamine neuronsS Erhardt
Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
Naunyn Schmiedebergs Arch Pharmacol 363:21-7. 2001..The aim of the present electrophysiological study was to investigate if manipulation of brain kynurenic acid, an endogenous excitatory amino acid receptor antagonist, can affect the response of nigral dopamine neurons ..
- Endogenous kynurenines as targets for drug discovery and developmentTrevor W Stone
Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
Nat Rev Drug Discov 1:609-20. 2002..As a result, the pathway presents a multitude of potential sites for drug discovery in neuroscience, oncology and visceral pathology...
- Early developmental elevations of brain kynurenic acid impair cognitive flexibility in adults: reversal with galantamineK S Alexander
Department of Psychology, The Ohio State University, Columbus, OH, USA Department of Neuroscience, The Ohio State University, Columbus, OH, USA
Neuroscience 238:19-28. 2013Levels of kynurenic acid (KYNA), an endogenous α7 nicotinic acetylcholine receptor (α7nAChR) antagonist, are elevated in the brain of patients with schizophrenia (SZ) and might contribute to the pathophysiology and cognitive deficits ..
- beta-adrenergic enhancement of brain kynurenic acid production mediated via cAMP-related protein kinase A signalingElzbieta Luchowska
Department of Experimental and Clinical Pharmacology, Skubiszewski Medical University, Jaczewskiego 8, 20 090 Lublin, Poland
Prog Neuropsychopharmacol Biol Psychiatry 33:519-29. 2009The central levels of endogenous tryptophan metabolite kynurenic acid (KYNA), an antagonist of N-methyl-d-aspartate (NMDA) and alpha7-nicotinic receptors, affect glutamatergic and dopaminergic neurotransmission...
- Dual effect of DL-homocysteine and S-adenosylhomocysteine on brain synthesis of the glutamate receptor antagonist, kynurenic acidE Luchowska
Department of Pharmacology and Toxicology, Skubiszewski Medical University of Lublin, Lublin, Poland
J Neurosci Res 79:375-82. 2005..The effect of homocysteine and metabolically related compounds on brain production of kynurenic acid (KYNA), an endogenous antagonist of glutamate ionotropic receptors, was studied...
- Fluctuations in endogenous kynurenic acid control hippocampal glutamate and memoryAna Pocivavsek
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Neuropsychopharmacology 36:2357-67. 2011b>Kynurenic acid (KYNA), an astrocyte-derived metabolite, antagonizes the α7 nicotinic acetylcholine receptor (α7nAChR) and, possibly, the glycine co-agonist site of the NMDA receptor at endogenous brain concentrations...
- Kynurenic acid in ALS patientsY Iwasaki
Acta Neurol Scand 109:236; author reply 437. 2004
- Endogenous activation of nAChRs and NMDA receptors contributes to the excitability of CA1 stratum radiatum interneurons in rat hippocampal slices: effects of kynurenic acidManickavasagom Alkondon
Division of Translational Toxicology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, 10 S Pine Street, Suite 900, Baltimore, MD 21201, United States
Biochem Pharmacol 82:842-51. 2011..b>Kynurenic acid (KYNA), an astrocyte-derived kynurenine metabolite whose levels are increased in the brains of patients with ..
- Ammonia at pathophysiologically relevant concentrations activates kynurenic acid synthesis in cultured astrocytes and neuronsKatarzyna Wejksza
Department of Virology and Immunology, Institute of Microbiology and Biotechnology, Maria Curie Skłodowska University, Akademicka 19, 20 033 Lublin, Poland
Neurotoxicology 27:619-22. 2006The synthesis of the NMDA receptor glycine site antagonist kynurenic acid (KYNA) from exogenously added kynurenine was measured in cultured cerebral cortical neurons, cortical astrocytes and an oligodendroglial cell line OLN-93, incubated ..
- The pentylenetetrazole-induced activity in the hippocampus can be inhibited by the conversion of L-kynurenine to kynurenic acid: an in vitro studyEva Rozsa
Department of Physiology, Anatomy and Neuroscience, University of Szeged, POB 533, H 6701 Szeged, Hungary
Brain Res Bull 76:474-9. 2008..including L-kynurenine, which in turn can be converted into the excitatory amino acid receptor antagonist kynurenic acid. The ionotropic glutamate receptors have been considered to be attractive targets for new anticonvulsants in ..
- Alteration of kynurenic acid concentration in rat plasma following optically pure kynurenine administration: a comparative study between enantiomersTakeshi Fukushima
Division of Bio Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Shizuoka, Japan
Chirality 21:468-72. 2009L-Kynurenine (KYN), a tryptophan metabolite, is metabolized to kynurenic acid (KYNA), which is an antagonist of N-methyl-D-aspartate and alpha7 nicotinic acetylcholine receptors, by kynurenine aminotransferase (KAT) I and KAT II...
- Enhancement of brain kynurenic acid production by anticonvulsants--novel mechanism of antiepileptic activity?Tomasz Kocki
Department of Pharmacology, Skubiszewski Medical University, Lublin, Poland
Eur J Pharmacol 541:147-51. 2006In this study, we describe the effect of antiepileptic drugs on the production of kynurenic acid in rat cortical slices, and on the activity of kynurenic acid biosynthetic enzymes, kynurenine aminotransferases (KATs I and II) in the brain ..
- Changes in the plasma concentrations of D-kynurenine and kynurenic acid in rats after intraperitoneal administration of tryptophan enantiomersKana Ishii
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Toho University, Funabashi shi, Chiba 274 8510, Japan
Chirality 22:901-6. 2010..The time-course profiles of the rat plasma concentrations of D-kynurenine (KYN), L-KYN, and kynurenic acid (KYNA), which are metabolites of D- or L-Trp, were investigated using high-performance liquid chromatography (..
- Distribution, synthesis, and absorption of kynurenic acid in plantsMichal P Turski
Department of Toxicology, Institute of Agricultural Medicine, Lublin, Poland
Planta Med 77:858-64. 2011b>Kynurenic acid (KYNA) is an endogenous antagonist of the ionotropic glutamate receptors and the α7 nicotinic acetylcholine receptor as well as an agonist of the G-protein-coupled receptor GPR35...
- Kynurenic acid, an endogenous constituent of rheumatoid arthritis synovial fluid, inhibits proliferation of synoviocytes in vitroJolanta Parada-Turska
Department of Rheumatology and Connective Tissue Diseases, Medical University, Jaczewskiego 8, 20 950 Lublin, Poland
Rheumatol Int 26:422-6. 2006b>Kynurenic acid is an antagonist of ionotropic glutamate receptors. It has been found that glutamate antagonists inhibit proliferation of different human tumor cells...
- Radical scavenging properties of tryptophan metabolites. Estimation of their radical reactivityK Goda
Faculty of Nutrition, Kobe Gakuin University, Japan
Adv Exp Med Biol 467:397-402. 1999..the reactivity of the second group (xanthurenic acid, serotonin, N-acetylserotonin) is similar to that of butylated hydroxytoluene (BHT); the third group (kynurenic acid, melatonin, and other ones) is less reactive than BHT.
- Modulation of quinolinic and kynurenic acid content in the rat brain: effects of endotoxins and nicotinylalanineF Moroni
Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
J Neurochem 57:1630-5. 1991Quinolinic acid, an endogenous excitotoxin, and kynurenic acid, an antagonist of excitatory amino acid receptors, are believed to be synthesized from tryptophan after the opening of the indole ring...
- Curiosity to kill the KAT (kynurenine aminotransferase): structural insights into brain kynurenic acid synthesisFranca Rossi
DiSCAFF Department of Chemical, Food, Pharmaceutical and Pharmacological Sciences, University of Piemonte Orientale A Avogadro, I 28100 Novara, Italy
Curr Opin Struct Biol 18:748-55. 2008Kynurenine aminotransferases are pyridoxal-5'-phosphate-dependent enzymes, which catalyze the synthesis of kynurenic acid, a highly neuroactive metabolite whose impairment is associated with a number of severe brain disorders...
- Kynurenic acid synthesis in cerebral cortical slices of rats with progressing symptoms of thioacetamide-induced hepatic encephalopathyTomasz Saran
Department of Pharmacology and Toxicology, Medical University, Lublin, Poland
J Neurosci Res 75:436-40. 2004..vitro and in vivo inhibits the production of a broad-spectrum antagonist of excitatory amino acid receptors, kynurenic acid (KYNA)...
- Clenbuterol enhances the production of kynurenic acid in brain cortical slices and glial culturesElzbieta Luchowska
Department of Pharmacology and Clinical Pharmacology, Skubiszewski Medical School, Jaczewskiego 8, PL 20 090 Lublin, Poland
Pharmacol Rep 60:574-7. 2008The effect of a beta(2)-adrenergic agonist, clenbuterol on the production of a glutamate receptor antagonist, kynurenic acid was studied in vitro. Clenbuterol enhanced the production of kynurenic acid in brain cortical slices (0.1-1...
- Neuroprotection by acetoacetate and β-hydroxybutyrate against NMDA-induced RGC damage in rat--possible involvement of kynurenic acidSebastian Thaler
Centre for Ophthalmology, University of Tubingen, Tubingen, Germany
Graefes Arch Clin Exp Ophthalmol 248:1729-35. 2010..Additionally, the influence of ACA and BHB on kynurenic acid (KYNA) production was assessed in vitro in bovine retinal slices.
- Changes in extracellular kynurenic acid concentrations in rat prefrontal cortex after D-kynurenine infusion: an in vivo microdialysis studyTadahiro Ogaya
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Toho University, Funabashi shi, Chiba, Japan
Neurochem Res 35:559-63. 2010..used column-switching high-performance liquid chromatography to assess the alterations in the concentration of kynurenic acid (KYNA)-an antagonist of N-methyl-D-aspartate and alpha7 nicotinic acetylcholine receptors-in the extracellular ..
- The peripheral antinociceptive effects of endomorphin-1 and kynurenic acid in the rat inflamed joint modelLaszlo Mecs
Department of Orthopedics, University of Szeged, Szeged, Hungary
Anesth Analg 109:1297-304. 2009..the antinociceptive potency of the endogenous opioid peptide, endomorphin-1 (EM1), and the endogenous NMDA receptor antagonist, kynurenic acid (KYNA), and their interaction at the peripheral level in the rat inflamed joint model.
- Kynurenic acid inhibits the release of the neurotrophic fibroblast growth factor (FGF)-1 and enhances proliferation of glia cells, in vitroClaudia Di Serio
Department of Critical Care Medicine and Surgery, Geriatric Medicine Unit, University of Florence, School of Medicine, Viale Pieraccini n 6, Florence, 50139, Italy
Cell Mol Neurobiol 25:981-93. 2005..4. Our data suggest that minor changes of local KYNA concentration may modulate FGF-1 release, cell proliferation, and ultimately tissue damage in different pathological conditions...
- High tryptophan diet reduces extracellular dopamine release via kynurenic acid production in rat striatumAlato Okuno
Department of Food Science and Nutrition, School of Human Cultures, The University of Shiga Prefecture, Shiga, Japan
J Neurochem 118:796-805. 2011At endogenous brain concentrations, the neuroinhibitory tryptophan metabolite kynurenic acid (KYNA) is a preferential antagonist of the α7 nicotinic acetylcholine receptor (α7nAChR)...
- Increased ratio of quinolinic acid to kynurenic acid in cerebrospinal fluid of D retrovirus-infected rhesus macaques: relationship to clinical and viral statusM P Heyes
Section on Analytical Biochemistry, National Institute of Mental Health, Bethesda, MD 20892
Ann Neurol 27:666-75. 1990..b>Kynurenic acid, an antagonist of excitatory amino acid receptors as well as the excitotoxic effects of quinolinic acid, was ..
- The kynurenate analog SZR-72 prevents the nitroglycerol-induced increase of c-fos immunoreactivity in the rat caudal trigeminal nucleus: comparative studies of the effects of SZR-72 and kynurenic acidE Knyihar-Csillik
Department of Neurology, Albert Szent Gyorgyi Clinical Center, University of Szeged, Szeged, 6 Semmelweis utca, H 6726 Szeged, Hungary
Neurosci Res 61:429-32. 2008..and second-order trigeminal neurons are mediated by excitatory amino acids, NMDA receptors are inhibited by kynurenic acid, though this crosses the blood-brain barrier only poorly...
- The Janus-face kynurenic acidEva Rozsa
Department of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, Hungary
J Neural Transm 115:1087-91. 2008b>Kynurenic acid is an endogenous product of the tryptophan metabolism...
- Quantitative differences in the effects of de novo produced and exogenous kynurenic acid in rat brain slicesH E Scharfman
Neurology Research Center, Helen Hayes Hospital, West Haverstraw, NY 10993 1195, USA
Neurosci Lett 274:111-4. 1999b>Kynurenic acid (KYNA) is an antagonist of (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors and it blocks the glycine site of the NMDA receptor preferentially (IC50 = 7...
- Kynurenic acid triggers firm arrest of leukocytes to vascular endothelium under flow conditionsMarita C Barth
Cardiology Division and Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Biol Chem 284:19189-95. 2009Recent studies have demonstrated that kynurenic acid (KYNA), a compound produced endogenously by the interferon-gamma-induced degradation of tryptophan by indoleamine 2,3-dioxygenase, activates the previously orphaned G protein-coupled ..
- Age-related increase of kynurenic acid in human cerebrospinal fluid - IgG and beta2-microglobulin changesBerthold Kepplinger
Department of Neurology, Klinikum Mostviertel Amstetten, General Hospital, Amstetten, Austria
Neurosignals 14:126-35. 2005b>Kynurenic acid (KYNA) is an endogenous metabolite in the kynurenine pathway of tryptophan degradation and is an antagonist at the glycine site of the N-methyl-D-aspartate as well as at the alpha 7 nicotinic cholinergic receptors...
- TRYPTOPHAN METABOLISM IN MOSQUITOESJianyong Li; Fiscal Year: 2007..Kynurenine, 3-hydroxykynurenine (3-HK), kynurenic acid (KA) and xanthurenic acid (XA) are the key components in the tryptophan catabolism, and kynurenine to KA and 3-..
- NEUROPHARMACOLOGY OF DRUGS OF ABUSE: AMPHETAMINEGEORGE REBEC; Fiscal Year: 2009..Collectively, our results will provide important, new information on the involvement of PFC neurons and their DA input in relapse to cocaine seeking. ..
- Phenotyping Major Depression with Increased InflammationAndrew H Miller; Fiscal Year: 2013..CSF) concentrations of metabolites of indoleamine 2,3 dioxygenase including kynurenine, quinolinic acid and kynurenic acid, which has been shown to reduce dopamine release in the basal ganglia...
- Pathogenesis of cognitive/neurologic deficits in central nervous system malariaChandy C John; Fiscal Year: 2012..g., CSF levels of ROS and RNS, pro- and anti-inflammatory cytokines, quinolinic and kynurenic acid, and tau and neuron- specific enolase),;and c) genetic polymorphisms in apolipoprotein-E and HO-1, which may ..
- Dopaminergic Mechanisms of Cytokine-Induced Behavioral ChangeAndrew H Miller; Fiscal Year: 2012..activation of MAPK has been shown to upregulate monoamine transporters, and cytokine-induced activation of kynurenic acid has been shown to decrease DA release...
- Kynurenic Acid Synthesis in Mouse BrainJianyong Li; Fiscal Year: 2010..b>Kynurenic acid (KYNA, a tryptophan metabolite) acts as a glutamate receptor antagonist and is believed to play a role in ..
- Biobehavioral Role of Brain Kynurenine Metabolism in Mental IllnessJASON C O'CONNOR; Fiscal Year: 2013..Conversely, endothelial cells and astrocytes produce kynurenic acid, which is a glutamate and 17-nicotinic acetylcholine receptor antagonist...
- Metabolite Profiling and Cardiovascular Mortality in End-stage Renal DiseaseEugene P Rhee; Fiscal Year: 2013..in select metabolic pathways in ESRD, and specifically advances 3 candidate metabolites - adipic acid, kynurenic acid, and choline - with potential relevance to cardiovascular outcomes...
- Endogenous Kynurenic Acid Modulates Prefrontal ACh Levels and Cognitive BehaviorRobert Schwarcz; Fiscal Year: 2013..Conversely, dysregulation of cortical 17nAChRs has been implicated in the etiology of SZ. Kynurenic acid (KYNA) is an astrocyte-derived neuromodulator that, at endogenous concentrations, inhibits 17nAChR activity in ..
- Clinical Development of 4-Cl-KYN to Treat PainRALPH SNODGRASS; Fiscal Year: 2010..4-CI-KYN is a pro-drug of 7-Chlorokynurenic acid (7-Cl-KYNA), a chlorinated analogue of kynurenic acid, which is a natural neuromodulator and one of the most potent and specific GlyB antagonists known to man, ..
- Nicotinic receptors: Role in hippocampal synaptic functionEdson X Albuquerque; Fiscal Year: 2012..In these disorders, decreased a7* nAChR activity is accompanied by increased brain levels of kynurenic acid (KYNA), an astrocyte-derived kynurenine metabolite that blocks a7* nAChRs and N-methyl-D-aspartate (NMDA) ..
- Dopaminergic Regulation of Pyramidal CellsAriel Y Deutch; Fiscal Year: 2013..in changes in key astrocytic factors that modulate extracellular Glu levels, including GLT1, mGluR3, xCT, and kynurenic acid. Changes in astrocytic proteins will be compared to changes in neuronal proteins (including VGluT1 and 2, ..
- DEVELOPMENTAL MODELS OF GATING DEFICITS IN SCHIZOPHRENIAMark A Geyer; Fiscal Year: 2010..of this grant are to examine the mechanistic role of alterations in the endogenous NMDA receptor antagonist, kynurenic acid (KYNA), and the stress-related neuropeptide, corticotropin releasing factor (CRF) in isolation- and immune-..
- Regulation of Airway Protective BehaviorsTeresa E Pitts; Fiscal Year: 2013..model of dystussia and dysphagia induced by microinjection of the endogenous excitatory amino acid antagonist, kynurenic acid, into the medial reticular formation...
- EXCITOTOXIN EFFECTS ON SPINAL CORD IN VITROJOHN DELFS; Fiscal Year: 1992..two possible mechanisms for the decreased effect of glutamate: the role of glutamate uptake and the role of kynurenic acid as an endogenous EAA antagonist...
- Neuroprotective Effects of Estrogen in Serotonin NeuronsJessica Henderson; Fiscal Year: 2007..tryptophan metabolism away from pathways in which tryptophan is converted to serotonin or the neuroprotective kynurenic acid, towards pathways in which tryptophan is converted to several neurotoxic metabolites...
- ROLE OF AMINO ACID RECEPTORS IN EPILEPTOGENESISROBERT BRADY; Fiscal Year: 1990..We have observed that the putative NMR-receptor antagonist, kynurenic acid, has anticonvulsant-like properties when applied by bath application to slices undergoing penicillin-induced ..
- EPILEPTIFORM ACTIVITY ON HIPPOCAMPAL MICROCULTURESMichael Segal; Fiscal Year: 1993..that are grown for prolonged periods in culture in the presence of blockers of synaptic activity (such as kynurenic acid and magnesium)...
- KYNURENINES, GLIA AND EPILEPSYRobert Schwarcz; Fiscal Year: 2006..These data suggest that kynurenic acid (KYNA), an astrocyte-derived, endogenous antagonist of N-methyl-D-aspartate (NMDA) and alpha7 nicotinic ..
- PERIAQUEDUCTAL GRAY MODULATION OF SYMPATHETIC DRIVELinda Hayward; Fiscal Year: 2002..In the long term it is hoped that the results of these studies will stimulate new investigations into the role of the dlPAG, A5 and the PBN in normal and pathophysiological cardiovascular regulation. ..
- Supramedullary control of respirationLinda Hayward; Fiscal Year: 2007..Furthermore, the results of this study will provide new insights into understanding of the role of supramedullary structures in modulating respiratory timing. [unreadable] [unreadable]..
- Genetic Polymorphism of a Schizophrenia EndophenotypeIkwunga Wonodi; Fiscal Year: 2007..Deciphering the genetic mechanisms of prefrontal dopamine dysfunction in schizophrenia would advance our understanding of the pathophysiology of schizophrenia and may help identify novel treatments. [unreadable] [unreadable] [unreadable]..
- NEUROPEPTIDES AND CARDIOVASCULAR REGULATIONVIRGINIA BROOKS; Fiscal Year: 2002....
- Humoral Interactions in long-term blood pressure controlVIRGINIA BROOKS; Fiscal Year: 2005..abstract_text> ..
- Supraspinal prostaglandins and descending controlMary Heinricher; Fiscal Year: 2008..unreadable] [unreadable]..
- BLOOD PRESSURE CONTROL BY FOREBRAIN & BRAINSTEM NEURONSSUSAN BARMAN; Fiscal Year: 2008..unreadable] [unreadable]..
- Dopamine cell impulse flow, reward and schizophreniaPaul Shepard; Fiscal Year: 2008..abstract_text> ..
- Interneuron Diversity and Hippocampal Network DynamicsGianmaria Maccaferri; Fiscal Year: 2006..Relating different interneurons and GABAergic inputs to clear functions may lead to important insight into the organizing principles of cortical networks in the normal brain and during disease. ..
- Behavioral Influences on Drug ToleranceJames Smith; Fiscal Year: 2005..Additionally, "multi-chamber" procedures will study generalization of those discriminative effects to performance of the same subjects in different circumstances. ..
- CHRONIC NEURAL CONTROL OF BLOOD PRESSUREALAN SVED; Fiscal Year: 2007..It is expected that these studies will increase our understanding of the role of the brain in the pathophysiology of hypertension, and may provide new insight to the treatment and prevention of hypertension. [unreadable] [unreadable]..
- BRAIN GALANIN RECEPTORS AND EPILEPSYAndrey Mazarati; Fiscal Year: 2006..abstract_text> ..
- Targets for selenium in prostate cancer preventionJOHN PINTO; Fiscal Year: 2009..The long-term goal of our reseach is to design appropriate dietary strategies for prevention of prostate cancer. ..
- CNS DA NEURONS--CELLULAR BASIS OF PATTERNED ACTIVITYPaul Shepard; Fiscal Year: 2002..abstract_text> ..
- Interleukin-1Beta in Central Pain Modulating CircuitsMary Heinricher; Fiscal Year: 2004..In providing additional tools to manipulate these systems, this work may ultimately lead to improved clinical treatment of pain. ..
- Kynurenic Acid Regulation of Stimulus ProcessingAmy Chess; Fiscal Year: 2006..DESCRIPTION (provided by applicant): This proposal tests the hypothesis that elevated levels of brain kynurenic acid (KYNA) interferes with attentional processing...
- Spontaneous Activity of Mitral CellsEDWIN GRIFF; Fiscal Year: 2002..Increased knowledge of the normal and basic physiology of olfactory neurons is essential for developing strategies to treat olfactory deficits. ..
- Migraine headache and central pain facilitating systemsMary M Heinricher; Fiscal Year: 2010..This idea is attractive because a central dysfunction could potentially explain the multiple triggers for migraine attached, as well as the range of associated symptoms, including nausea and aversion to light and sound. ..
- Neuronal Mechanisms of Opioid ActionHong Zhu; Fiscal Year: 2004..These experiments will improve our understanding of neuronal mechanisms of opioid action, which is crucial for understanding and perhaps treating of opioid addiction. ..
- Morphine Like Brain Peptides-Cellular NeurobiologyGEORGE SIGGINS; Fiscal Year: 2008..These studies may help define the role of opioids and their receptors in behavior and provide rational targets for therapeusis of opiate "craving. [unreadable] [unreadable]..
- SENESCENCE ALTERS SYMPATHETIC REGULATION TO HEAT STRESSMICHAEL KENNEY; Fiscal Year: 2004..The proposed studies will, for the first time, advance the hypothesis that the working strategies employed by sympathetic neural circuits to respond to heat stress are modified by aging. ..
- MYELINATION--ASSEMBLY OF LIPIDS AND PROTEINSJOYCE BENJAMINS; Fiscal Year: 2003..abstract_text> ..
- SOMATOSTATIN RELATED PEPTIDES AND BRAIN FUNCTIONGEORGE SIGGINS; Fiscal Year: 2003..abstract_text> ..
- CENTRAL NEURONAL MECHANISMS--DECOMPENSATED HEMORRHAGEPATRICE GUYENET; Fiscal Year: 2003..Understanding the neurophysiological mechanisms triggered by hypotensive hemorrhage should lead to improved ability to manage this all too frequent clinical problem. ..
- Contribution of the PAG to morphine toleranceMichael Morgan; Fiscal Year: 2002..In the long term, such knowledge should improve the treatment of pain by allowing therapies that disrupt tolerance to be developed. ..
- SUBCORTICAL MODULATION OF THE DORSAL VAGAL COMPLEXXueguo Zhang; Fiscal Year: 2002....
- BRAIN/PELVIC VISCERA INTERACTIONS IN PSYCHIATRIC DISEASERITA VALENTINO; Fiscal Year: 2001....
- ETHANOL SENSITIVITY OF NATIVE AND CLONED NMDA RECEPTORSJohn Woodward; Fiscal Year: 2009..Aim 3 will express ethanol-insensitive receptors identified in Aims 1 and 2 in neurons in vitro and in vivo to address which effects of ethanol are mediated by inhibition of NMDA receptors. ..
- Electrical Synapses and Network SignalingGianmaria Maccaferri; Fiscal Year: 2010..Discovering new mechanisms of synaptic modulation could reveal additional targets for therapeutic intervention that could be exploited by a new generation of drugs, which is currently under development and testing. ..
- Protein ubiquitination based neuroprotection for strokeRobert Meller; Fiscal Year: 2006....
- Medullary Circuitry of Opioid AnalgesiaMary Heinricher; Fiscal Year: 2006..The proposed work should advance our understanding of central processes involved in bi-directional pain modulation, and should ultimately lead to improved clinical treatment of pain. ..
- Ethanol sensitivity--native /recombinant NMDA receptorsJohn Woodward; Fiscal Year: 2006..The successful completion of this training plan will substantially enhance the PI's research expertise and his ability to fulfill the goals of his research. ..
- Bladder Regulation by Corticotropin-Releasing FactorRITA VALENTINO; Fiscal Year: 2006..These studies unite complementary expertise from laboratories in urology and basic neuroscience to increase our knowledge of the central regulation of urinary function in normal and pathological state. [unreadable] [unreadable]..
- Intertrigeminal region control of apneaMiodrag Radulovacki; Fiscal Year: 2007..abstract_text> ..
- Pharmacoresistant limbic epilepsy: model validationEdward Bertram; Fiscal Year: 2005..This project will meet the program goals by establishing baseline data and introducing new methods for evaluating the therapeutic potential of novel compounds for the treatment of epilepsy. ..
- BIOGENIC AMINE SYSTEMS, CRF, AND STRESSRITA VALENTINO; Fiscal Year: 2005..Like the previous K02 award, the K05 award will promote future career development by providing stable salary support and flexibility to enhance technical skills and conceptual bases and promoting leadership. ..
- Rapid ischemic tolerance: Ubiquitin-mediated structural reorganizationRobert Meller; Fiscal Year: 2007..Indeed, the long-term aim of these studies is to discover endogenous protective mechanisms that can be translated into effective rapid acting neuroprotective agents for stroke. [unreadable] [unreadable] [unreadable]..
- ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYSPATRICE GUYENET; Fiscal Year: 2008..The research will contribute to the basic physiological knowledge needed to understand how syrr pathetic tone is regulated in health and in diseases such as arrhythmias, hypertension and dysautonomias. ..
- Sympathetic-Immune Interface: Central Sites & FunctionMICHAEL KENNEY; Fiscal Year: 2005..Ultimately, these findings may allow for the design of intervention strategies in immune regulation fostering robust and appropriate communication between the immune and nervous systems. ..
- Neural circuitry of improgran analgesiaMary M Heinricher; Fiscal Year: 2010....
- Volatile Anesthetic Action in Vertebrate Locomotor SystemsSteven L Jinks; Fiscal Year: 2010..Results from these projects will increase our understanding of how and where anesthetics act in the nervous system, contributing to the development of safer anesthetics and clinical practices. ..