rotenone

Summary

Summary: A botanical insecticide that is an inhibitor of mitochondrial electron transport.

Top Publications

  1. ncbi Protective effect of melatonin on rotenone plus Ca2+-induced mitochondrial oxidative stress and PC12 cell death
    Solange C Sousa
    , , Universidade Estadual de Campinas, Campinas, Brazil
    Antioxid Redox Signal 7:1110-6. 2005
  2. ncbi Production of reactive oxygen species by mitochondria: central role of complex III
    Qun Chen
    Department of Medicine, Division of Cardiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 278:36027-31. 2003
  3. ncbi Topology of superoxide production from different sites in the mitochondrial electron transport chain
    Julie St-Pierre
    MRC Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, England
    J Biol Chem 277:44784-90. 2002
  4. ncbi Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease
    Todd B Sherer
    Center for Neurodegenerative Disease, Rollins School of Public Health, Atlanta, Georgia 15213, USA
    J Neurochem 100:1469-79. 2007
  5. ncbi Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease
    James G Greene
    Department of Neurology, Emory University School of Medicine, 505H Whitehead Biomedical Research Bldg, 615 Michael St, Atlanta, GA 30322, USA
    Exp Neurol 218:154-61. 2009
  6. ncbi Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures
    Claudia M Testa
    Center for Neurodegenerative Disease, Emory University, Atlanta, GA 30322, USA
    Brain Res Mol Brain Res 134:109-18. 2005
  7. ncbi Hydrogen sulfide inhibits rotenone-induced apoptosis via preservation of mitochondrial function
    Li Fang Hu
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Mol Pharmacol 75:27-34. 2009
  8. ncbi Parkinsonian rotenone mouse model: reevaluation of long-term administration of rotenone in C57BL/6 mice
    Masatoshi Inden
    Department of Neurobiology, Kyoto Pharmaceutical University, Japan
    Biol Pharm Bull 34:92-6. 2011
  9. ncbi Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation
    Todd B Sherer
    Center for Neurodegenerative Disease, Department of Neurology, Emory University, Atlanta, GA 30032, USA
    Exp Neurol 179:9-16. 2003
  10. ncbi Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production
    Nianyu Li
    Purdue University Cytometry Laboratories, Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 278:8516-25. 2003

Research Grants

  1. FLOW AND METABOLIC TRACER KINETICS IN HEART
    Robert Marshall; Fiscal Year: 2002
  2. GI Endotoxin as an Environmental Trigger in an alpha-Synuclein Transgenic Mouse
    Robert L Nussbaum; Fiscal Year: 2010
  3. Proteomic Studies in Parkinson's Disease
    Jing Zhang; Fiscal Year: 2007
  4. NADH-UBIQUINONE REDUCTASE OF PARACOCCUS DENITRIFICANS
    Takao Yagi; Fiscal Year: 1993
  5. PROTON & ELECTRON TRANSFER & ENERGY COUPLING
    Tomoko Ohnishi; Fiscal Year: 1992
  6. Oxidative modification of brain proteins in pesticide intoxication
    PIER MASTROBERARDINO; Fiscal Year: 2007
  7. Deep Brain Stimulation in Parkinson's Models
    Marjorie Anderson; Fiscal Year: 2006
  8. Mitochondrial Response to Oxidative Stress
    DANIEL BOGENHAGEN; Fiscal Year: 2006
  9. Interaction Between Genes and the Mitochondria in Parkin
    Benjamin Wolozin; Fiscal Year: 2007
  10. Interaction Between Genes and the Mitochondria in Parkin
    Benjamin L Wolozin; Fiscal Year: 2010

Detail Information

Publications258 found, 100 shown here

  1. ncbi Protective effect of melatonin on rotenone plus Ca2+-induced mitochondrial oxidative stress and PC12 cell death
    Solange C Sousa
    , , Universidade Estadual de Campinas, Campinas, Brazil
    Antioxid Redox Signal 7:1110-6. 2005
    Chronic systemic inhibition of mitochondrial respiratory chain complex I by rotenone causes nigrostriatal dopaminergic degeneration in rats, producing an in vivo experimental model of Parkinson's disease...
  2. ncbi Production of reactive oxygen species by mitochondria: central role of complex III
    Qun Chen
    Department of Medicine, Division of Cardiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 278:36027-31. 2003
    ..Limitation of electron transport by the inhibitor rotenone immediately before ischemia decreases the production of ROS in cardiac myocytes and reduces damage to ..
  3. ncbi Topology of superoxide production from different sites in the mitochondrial electron transport chain
    Julie St-Pierre
    MRC Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, England
    J Biol Chem 277:44784-90. 2002
    ..However, when complex I was fully reduced using rotenone, rat mitochondria released significantly more hydrogen peroxide than pigeon mitochondria...
  4. ncbi Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease
    Todd B Sherer
    Center for Neurodegenerative Disease, Rollins School of Public Health, Atlanta, Georgia 15213, USA
    J Neurochem 100:1469-79. 2007
    Parkinson's disease (PD) has been linked to mitochondrial dysfunction and pesticide exposure. The pesticide rotenone (ROT) inhibits complex I and reproduces features of PD in animal models, suggesting that environmental agents that ..
  5. ncbi Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease
    James G Greene
    Department of Neurology, Emory University School of Medicine, 505H Whitehead Biomedical Research Bldg, 615 Michael St, Atlanta, GA 30322, USA
    Exp Neurol 218:154-61. 2009
    ..We report that the parkinsonian neurotoxin and mitochondrial complex I inhibitor rotenone causes delayed gastric emptying and enteric neuronal dysfunction when administered chronically to rats in the ..
  6. ncbi Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures
    Claudia M Testa
    Center for Neurodegenerative Disease, Emory University, Atlanta, GA 30322, USA
    Brain Res Mol Brain Res 134:109-18. 2005
    b>Rotenone, a pesticide and complex I inhibitor, causes nigrostriatal degeneration similar to Parkinson disease pathology in a chronic, systemic, in vivo rodent model [M. Alam, W.J...
  7. ncbi Hydrogen sulfide inhibits rotenone-induced apoptosis via preservation of mitochondrial function
    Li Fang Hu
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Mol Pharmacol 75:27-34. 2009
    ..The present study was undertaken to investigate the effects of H(2)S on cell injury induced by rotenone, a commonly used toxin in establishing in vivo and in vitro Parkinson's disease (PD) models, in human-derived ..
  8. ncbi Parkinsonian rotenone mouse model: reevaluation of long-term administration of rotenone in C57BL/6 mice
    Masatoshi Inden
    Department of Neurobiology, Kyoto Pharmaceutical University, Japan
    Biol Pharm Bull 34:92-6. 2011
    Chronic systemic exposure of Lewis rats to rotenone produced many features of Parkinson's disease (PD), including nigrostriatal dopamine (DA) neurodegeneration and the formation of cytoplasmic inclusions in nigral DA neurons...
  9. ncbi Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation
    Todd B Sherer
    Center for Neurodegenerative Disease, Department of Neurology, Emory University, Atlanta, GA 30032, USA
    Exp Neurol 179:9-16. 2003
    Previous studies demonstrated that chronic systemic exposure to the pesticide and mitochondrial toxin rotenone through jugular vein cannulation reproduced many features of Parkinson's disease (PD) in rats, including nigrostriatal ..
  10. ncbi Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production
    Nianyu Li
    Purdue University Cytometry Laboratories, Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 278:8516-25. 2003
    Inhibition of mitochondrial respiratory chain complex I by rotenone had been found to induce cell death in a variety of cells. However, the mechanism is still elusive...
  11. ncbi Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat
    Won Seok Choi
    Toxicology Program, Department of Environmental and Occupational Health Sciences, Graduate Program in Neurobiology and Behavior, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195 7234, USA
    Proc Natl Acad Sci U S A 105:15136-41. 2008
    ..Although dopaminergic neurons were more sensitive than other neurons in these cultures to cell death induced by rotenone, MPP(+), or paraquat treatments, the absence of complex I activity did not protect the dopaminergic neurons, as ..
  12. ncbi Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone
    Masatoshi Inden
    Department of Neurobiology and 21st Century COE Program, Kyoto Pharmaceutical University, Kyoto, Japan
    J Neurochem 101:1491-1504. 2007
    ..Previous studies have demonstrated that chronic systemic exposure of Lewis rats to rotenone produced many features of PD, and cerebral tauopathy was also detected in the case of severe weight loss...
  13. ncbi JNK3 mediates paraquat- and rotenone-induced dopaminergic neuron death
    Won Seok Choi
    Toxicology Program in the Department of Environmental and Occupational Health Sciences, Graduate Program in Neurobiology and Behavior, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, USA
    J Neuropathol Exp Neurol 69:511-20. 2010
    ..kinase 3 (JNK3), a neural-specific JNK isoform, in dopaminergic neuron death induced by the pesticides rotenone and paraquat. The role of JNK3 was evaluated using RNA silencing and gene deletion to block JNK3 signaling...
  14. ncbi Increased striatal dopamine turnover following acute administration of rotenone to mice
    C Thiffault
    The Parkinson s Institute, Sunnyvale, CA 94089, USA
    Brain Res 885:283-8. 2000
    ..potential role of mitochondrial dysfunction in nigrostriatal degeneration in Parkinson's disease, the effects of rotenone (an inhibitor of mitochondrial NADH dehydrogenase and a naturally occurring toxicant) on the levels of striatal ..
  15. ncbi Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons
    Hui Ming Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Neurosci 23:6181-7. 2003
    ..Chronic exposure to rotenone, a common herbicide, reproduces features of Parkinsonism in rats...
  16. ncbi Parkin protects dopaminergic neurons against microtubule-depolymerizing toxins by attenuating microtubule-associated protein kinase activation
    Yong Ren
    Department of Physiology and Biophysics, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 284:4009-17. 2009
    ..prevented parkin from protecting midbrain dopaminergic neurons against microtubule-depolymerizing toxins such as rotenone or colchicine...
  17. ncbi Epigallocatechin gallate (EGCG) potentiates the cytotoxicity of rotenone in neuroblastoma SH-SY5Y cells
    Woon Gye Chung
    Department of Chemistry, Oregon State University Corvallis, Oregon 97331, USA
    Brain Res 1176:133-42. 2007
    Exposure to rotenone, a widely used pesticide, has been suggested to increase the risk of developing Parkinson's disease...
  18. ncbi Rotenone, paraquat, and Parkinson's disease
    Caroline M Tanner
    The Parkinson s Institute, Sunnyvale, California 94085, USA
    Environ Health Perspect 119:866-72. 2011
    ..Certain pesticides may affect these mechanisms, but no pesticide has been definitively associated with PD in humans...
  19. ncbi Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease
    Jinghua Jin
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Mol Cell Proteomics 5:1193-204. 2006
    ..Manipulations of mortalin level in dopaminergic neurons resulted in significant changes in sensitivity to PD phenotypes via pathways involving mitochondrial and proteasomal function as well as oxidative stress...
  20. ncbi Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease
    Marc Meulener
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Curr Biol 15:1572-7. 2005
    ..however, they display a striking selective sensitivity to those environmental agents, including paraquat and rotenone, linked to PD in humans...
  21. ncbi Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: involvement of alpha-synuclein
    Barbara Monti
    Department of Biology, University of Bologna, Bologna, Italy
    Neurotox Res 17:130-41. 2010
    ..of nigro-striatal dopaminergic neurons is obtained through sub-chronic administration of the mitochondrial toxin, rotenone, via osmotic mini pumps implanted to rats...
  22. ncbi Redox-dependent modulation of aconitase activity in intact mitochondria
    Anne Laure Bulteau
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106 4970, USA
    Biochemistry 42:14846-55. 2003
    ....
  23. ncbi Rotenone induces apoptosis in MCF-7 human breast cancer cell-mediated ROS through JNK and p38 signaling
    Yea Tzy Deng
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Carcinog 49:141-51. 2010
    b>Rotenone is an inhibitor of the mitochondrial electron transport chain complex I, resulting in the generation of reactive oxygen species (ROS)...
  24. ncbi Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity after partial respiratory inhibition of mitochondrial complex I with rotenone
    Nagendra Yadava
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurosci 27:7310-7. 2007
    Partial inhibition of mitochondrial respiratory complex I by rotenone reproduces aspects of Parkinson's disease in rodents...
  25. ncbi Neuronal expression of a single-subunit yeast NADH-ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan
    Sepehr Bahadorani
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095 1527, USA
    Aging Cell 9:191-202. 2010
    ..These findings are consistent with the idea that enhanced respiratory chain activity in neuronal tissue can prolong fly lifespan...
  26. ncbi Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species
    Romana Fato
    Dipartimento di Biochimica G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Biochim Biophys Acta 1787:384-92. 2009
    ..Our results indicate that different Complex I inhibitors can be grouped into two classes: Class A inhibitors (Rotenone, Piericidin A and Rolliniastatin 1 and 2) increase ROS production; Class B inhibitors (Stigmatellin, Mucidin, ..
  27. ncbi Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease
    T A Yacoubian
    Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cell Death Dis 1:e2. 2010
    ..overexpressing each 14-3-3 isoform, we found that overexpression of 14-3-3θ, ε, or γ led to resistance to both rotenone and 1-methyl-4-phenylpyridinium (MPP(+)), while other isoforms were not protective against both toxins...
  28. ncbi Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons
    Hui-Ming Gao
    Neuropharmacology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Neurosci 22:782-90. 2002
    ..In experimental animals the exposure to a common herbicide, rotenone, induces features of parkinsonism; mechanistically, rotenone-induced destruction of dopaminergic neurons has been ..
  29. ncbi Role of nitric oxide in rotenone-induced nigro-striatal injury
    Yi He
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurochem 86:1338-45. 2003
    b>Rotenone, a widely used pesticide, causes a syndrome in rats that mimics, both behaviorally and pathologically, the symptoms of Parkinson's disease...
  30. ncbi Rotenone-induced G2/M cell cycle arrest and apoptosis in a human B lymphoma cell line PW
    J S Armstrong
    Department of Radiation Oncology, Stanford University Medical Center, Stanford, California 94305 5105, USA
    Biochem Biophys Res Commun 289:973-8. 2001
    Concentrations of rotenone (ROT) that block electron flow through mitochondrial complex I (100 nM) did not significantly alter either cell viability or the growth of PW cells...
  31. ncbi Effects of insulin-like growth factor-1 on rotenone-induced apoptosis in human lymphocyte cells
    Isabel Cristina Avila-Gomez
    School of Medicine, Medical Research Institute, Neuroscience Research Program, University of Antioquia, Medellin, Colombia
    Basic Clin Pharmacol Toxicol 106:53-61. 2010
    ..The present work shows that rotenone, a mitochondrial complex I inhibitor, induced time- and concentration-dependent apoptosis in lymphocytes which ..
  32. ncbi Mechanism of toxicity in rotenone models of Parkinson's disease
    Todd B Sherer
    Center for Neurodegenerative Disease, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 23:10756-64. 2003
    Exposure of rats to the pesticide and complex I inhibitor rotenone reproduces features of Parkinson's disease, including selective nigrostriatal dopaminergic degeneration and alpha-synuclein-positive cytoplasmic inclusions (Betarbet et al...
  33. ncbi Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice
    Francisco Pan-Montojo
    Institute of Anatomy, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
    PLoS ONE 5:e8762. 2010
    ..Here we report that intragastrically administered rotenone, a commonly used pesticide that inhibits Complex I of the mitochondrial respiratory chain, is able to reproduce ..
  34. ncbi Mechanism for generation of hydrogen peroxide and change of mitochondrial membrane potential during rotenone-induced apoptosis
    Saeko Tada-Oikawa
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2-174 Edobashi, Tsu-Shi, Mie, 514-8507, Japan
    Life Sci 73:3277-88. 2003
    b>Rotenone, an inhibitor of NADH dehydrogenase complex, is a naturally occurring insecticide, which is capable of inducing apoptosis...
  35. ncbi The effect of antiparkinsonian drugs on oxidative stress induced pathological [3H]dopamine efflux after in vitro rotenone exposure in rat striatal slices
    Elisaveta Milusheva
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H 1083 Budapest, Szigony u 43, Hungary
    Neuropharmacology 58:816-25. 2010
    ..60 min rotenone (0...
  36. ncbi Stereotaxical infusion of rotenone: a reliable rodent model for Parkinson's disease
    Nian Xiong
    Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China
    PLoS ONE 4:e7878. 2009
    ..we developed a rat model by stereotaxically (ST) infusing small doses of the mitochondrial complex-I inhibitor, rotenone, into two brain sites: the right ventral tegmental area and the substantia nigra...
  37. ncbi Coenzyme Q cytoprotective mechanisms for mitochondrial complex I cytopathies involves NAD(P)H: quinone oxidoreductase 1(NQO1)
    Tom S Chan
    Faculty of Pharmacy, University of Toronto, Ont, Canada
    Free Radic Res 36:421-7. 2002
    ..as a model cell, we have shown for the first time that the cytotoxicity caused by complex I inhibition by rotenone but not that caused by complex III inhibition by antimycin can be prevented by coenzyme Q (CoQ1) or menadione...
  38. ncbi Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models
    Hiroki Takeuchi
    Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Neurosci Res 87:576-85. 2009
    ..To assess the protective effect of nicotine against rotenone-induced DA neuronal cell toxicity, we examined the neuroprotective effects of nicotine in rotenone-induced PD ..
  39. ncbi Pretreatment with near-infrared light via light-emitting diode provides added benefit against rotenone- and MPP+-induced neurotoxicity
    Rong Ying
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Brain Res 1243:167-73. 2008
    ..The present study used these specific mitochondrial complex I inhibitors (rotenone and 1-methyl-4-phenylpyridinium or MPP(+)) on striatal and cortical neurons in culture...
  40. ncbi Protective effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline against dopaminergic neurodegeneration in the extrapyramidal structures produced by intracerebral injection of rotenone
    Lucyna Antkiewicz-Michaluk
    Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    Int J Neuropsychopharmacol 7:155-63. 2004
    The aim of this paper was to investigate whether rotenone, a pesticide causing experimental parkinsonism, causes direct damage to dopaminergic structure when injected intracerebrally and whether this action may be prevented by peripheral ..
  41. ncbi The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy
    Günter U Höglinger
    INSERM U679, Hopital de la Salpetriere, Paris, France
    J Neurochem 95:930-9. 2005
    ..on the distribution of alpha-synuclein or tau, we infused rats systemically with the plant-derived isoflavonoid rotenone. Rotenone-treated rats with a pronounced metabolic impairment had reduced locomotor activity, dystonic limb ..
  42. ncbi Depressive-like behaviors alterations induced by intranigral MPTP, 6-OHDA, LPS and rotenone models of Parkinson's disease are predominantly associated with serotonin and dopamine
    Ronise M Santiago
    Laboratorio de Fisiologia e Farmacologia do Sistema Nervoso Central, Departamento de Farmacologia, Universidade Federal do Parana, Curitiba, PR, Brasil
    Prog Neuropsychopharmacol Biol Psychiatry 34:1104-14. 2010
    ..1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 6-hydroxydopamine (6-OHDA), lipopolysaccharide (LPS) and rotenone are able to induce depressive-like behaviors and neurotransmitters alterations similarly that encountered in PD...
  43. ncbi Mitochondrial complex I inhibitor rotenone-elicited dopamine redistribution from vesicles to cytosol in human dopaminergic SH-SY5Y cells
    Masahiko Watabe
    Department of Pharmacology, Teikyo University School of Medicine, Tokyo, Japan
    J Pharmacol Exp Ther 323:499-507. 2007
    ..b>Rotenone, a pesticide, produces selective degeneration of dopaminergic neurons and motor dysfunction in rats...
  44. ncbi Long-term efficacy and safety of human umbilical cord mesenchymal stromal cells in rotenone-induced hemiparkinsonian rats
    Nian Xiong
    Department of Neurology, Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, People s Republic of China
    Biol Blood Marrow Transplant 16:1519-29. 2010
    ..effects of human umbilical cord mesenchymal stromal cells (HUMSCs) 1 year after transplantation into rotenone-induced hemiparkinsonian rats...
  45. ncbi Apoptosis induction by the natural product cancer chemopreventive agent deguelin is mediated through the inhibition of mitochondrial bioenergetics
    N Hail
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Apoptosis 9:437-47. 2004
    ..These results demonstrate that deguelin induces apoptosis in skin cancer cells by inhibiting mitochondrial bioenergetics and provide a novel mechanism for the putative anticancer activity of this agent...
  46. ncbi The parkinsonian neurotoxin rotenone activates calpain and caspase-3 leading to motoneuron degeneration in spinal cord of Lewis rats
    S Samantaray
    Department of Neurosciences, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 309 CSB, P O Box 250606, Charleston, SC 29425, USA
    Neuroscience 146:741-55. 2007
    ..b>Rotenone is a neurotoxin that has been used to induce experimental Parkinsonism in rats...
  47. ncbi Metabolic profiles show specific mitochondrial toxicities in vitro in myotube cells
    Qiuwei Xu
    Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486, USA
    J Biomol NMR 49:207-19. 2011
    ..the application of quantitative NMR metabolomics to in vitro myotube cells treated with mitochondrial toxicants, rotenone and antimycin A...
  48. ncbi Effects of rotenone and pyridaben on complex I electron transfer and on mitochondrial nitric oxide synthase functional activity
    Ana Navarro
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cadiz, Plaza Fragela 9, 11003 Cadiz, Spain
    J Bioenerg Biomembr 42:405-12. 2010
    b>Rotenone and pyridaben were tested on activities and properties of rat brain mitochondria determining Ki (inhibitor concentration at half maximal inhibition) and Imax (% of inhibition at maximal inhibitor concentration)...
  49. ncbi Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts
    Heather Mortiboys
    Academic Neurology Unit, Medical School, University of Sheffield, Sheffield, United Kingdom
    Ann Neurol 64:555-65. 2008
    ..The aim of our study was to determine mitochondrial function and morphology in parkin-mutant patients. We also investigated whether pharmacological rescue of impaired mitochondrial function may be possible in parkin-mutant human tissue...
  50. ncbi Mitochondrial complex I inhibitor rotenone inhibits and redistributes vesicular monoamine transporter 2 via nitration in human dopaminergic SH-SY5Y cells
    Masahiko Watabe
    Department of Pharmacology, Teikyo University School of Medicine, 2 11 1, Kaga, Itabashi ku, Tokyo 173 8605, Japan
    Mol Pharmacol 74:933-40. 2008
    ..Long-term systemic mitochondrial complex I inhibition by rotenone induces selective degeneration of dopaminergic neurons in rats...
  51. ncbi Rotenone potentiates dopamine neuron loss in animals exposed to lipopolysaccharide prenatally
    Zaodung Ling
    Department of Pharmacology, Rush University Medical Center, Chicago, IL 60612, USA
    Exp Neurol 190:373-83. 2004
    ..treating female Sprague-Dawley rats exposed to LPS or saline prenatally with a subtoxic dose of the DA neurotoxin rotenone (1.25 mg/kg per day) or vehicle for 14 days when they were 16 months old...
  52. ncbi Mechanism of the neuroprotective role of coenzyme Q10 with or without L-dopa in rotenone-induced parkinsonism
    Amany A Abdin
    Department of Pharmacology, Faculty of Medicine, Tanta University, Al Geish Street, Tanta, Egypt
    Neuropharmacology 55:1340-6. 2008
    ..the light on the role of coenzyme Q10 with or without L-dopa in an experimental model of parkinsonism induced by rotenone in rats. The present work showed that rotenone (2.5 mg/kg/day i.p...
  53. ncbi Partial mitochondrial inhibition causes striatal dopamine release suppression and medium spiny neuron depolarization via H2O2 elevation, not ATP depletion
    Li Bao
    Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 25:10029-40. 2005
    ..We show here that acute exposure to the mitochondrial complex I inhibitor rotenone (30-100 nM; 30 min) causes concentration-dependent suppression of single-pulse evoked dopamine (DA) release ..
  54. ncbi Increased vulnerability to rotenone-induced neurotoxicity in ceruloplasmin-deficient mice
    Kazuma Kaneko
    Department of Neurology and Rheumatology, Shinshu University School of Medicine, 3 1 1 Asahi, 390 8621 Matsumoto, Japan
    Neurosci Lett 446:56-8. 2008
    ..b>Rotenone, a selective mitochondrial complex I inhibitor, induces neurodegeneration mimicking Parkinson's disease...
  55. ncbi Neuroprotective efficacy of Bacopa monnieri against rotenone induced oxidative stress and neurotoxicity in Drosophila melanogaster
    Ravikumar Hosamani
    Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Council of Scientific and Industrial Research, Mysore 570020, India
    Neurotoxicology 30:977-85. 2009
    ..Environmental toxins like rotenone, a specific inhibitor of complex I is employed to increase oxidative stress mediated neuropathology and sporadic ..
  56. ncbi Pesticide/environmental exposures and Parkinson's disease in East Texas
    Amanpreet S Dhillon
    Department of Occupational Health Sciences, University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    J Agromedicine 13:37-48. 2008
    ..is little human data on risk associated with specific pesticide products, including organic pesticides such as rotenone with PD...
  57. ncbi Paraquat neurotoxicity is distinct from that of MPTP and rotenone
    Jason R Richardson
    Center for Neurodegenerative Disease, School of Medicine and Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Toxicol Sci 88:193-201. 2005
    Paraquat, MPTP, and rotenone reproduce features of Parkinson's disease (PD) in experimental animals...
  58. ncbi Rotenone induces cell death in primary dopaminergic culture by increasing ROS production and inhibiting mitochondrial respiration
    Khaled Radad
    Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt
    Neurochem Int 49:379-86. 2006
    ..from embryonic mouse mesencephala were applied to investigate the toxic effects and underlying mechanisms of rotenone-induced neuronal cell death relevant to Parkinson's disease...
  59. ncbi Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity
    H L Liang
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuroscience 153:963-74. 2008
    ..The current study tested our hypothesis that LED treatment can protect neurons from both rotenone- and MPP(+)-induced neurotoxicity...
  60. ncbi Protection by the NDI1 gene against neurodegeneration in a rotenone rat model of Parkinson's disease
    Mathieu Marella
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 3:e1433. 2008
    ..In fact, rotenone, a complex I inhibitor, has been used for establishing PD models both in vitro and in vivo...
  61. ncbi Metabolic stress in PC12 cells induces the formation of the endogenous dopaminergic neurotoxin, 3,4-dihydroxyphenylacetaldehyde
    I Lamensdorf
    CNS, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Neurosci Res 60:552-8. 2000
    ..The rapid appearance of DOPAL and DOPET after inhibition of complex I may be a useful early index of oxidative stress in DA-forming neurons...
  62. ncbi The neurobehavioral changes induced by bilateral rotenone lesion in medial forebrain bundle of rats are reversed by L-DOPA
    M Alam
    Zoological Institute, Neuropharmacology, University of Tuebingen, Morgenstelle 28E, Tuebingen 72076, Germany
    Behav Brain Res 151:117-24. 2004
    b>Rotenone (an inhibitor of mitochondrial complex I) has been proposed as a model of Parkinson's disease (PD) as it induces nigrostriatal degeneration associated with alpha-synuclein inclusions...
  63. ncbi Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system
    Ranjita Betarbet
    Center for Neurodegenerative Disease, Center for Neurodegenerative Diseases, Whitehead Biomedical Research Building, 615 Michael Street, Atlanta, GA 30322, USA
    Neurobiol Dis 22:404-20. 2006
    ..here, we used in vivo and in vitro models of chronic low-grade complex I inhibition with the pesticide rotenone. Chronic rotenone exposure in vivo caused oxidative modification of DJ-1, accumulation of alpha-synuclein, and ..
  64. ncbi PACAP protects neuronal differentiated PC12 cells against the neurotoxicity induced by a mitochondrial complex I inhibitor, rotenone
    Gang Wang
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Second Medical University, Shanghai, China
    FEBS Lett 579:4005-11. 2005
    ..Here, we showed that PACAP27 protects against neurotoxicity induced by rotenone, a mitochondrial complex I inhibitor that has been implicated in the pathogenesis of Parkinson's disease (PD)...
  65. ncbi The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK-PD experiments
    Paulien G M Ravenstijn
    Leiden Amsterdam Center for Drug Research, Leiden University, Division of Pharmacology, Leiden, The Netherlands
    J Pharmacol Toxicol Methods 57:114-30. 2008
    ..transport mechanisms in the course of Parkinsons disease (PD) progression, experiments were performed to characterise Parkinsons disease markers following subcutaneous (SC) and intracerebral (IC) infusion of the toxin rotenone in the rat.
  66. ncbi Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation
    Sampath Ramachandiran
    Center for Neurodegenerative Disease, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Toxicol Sci 95:163-71. 2007
    Paraquat, N-methyl-4-phenyl-1,2,3,6 tetrahydropyridine, and rotenone have been shown to reproduce several features of Parkinson's disease in animal and cell culture models...
  67. ncbi Opening of microglial K(ATP) channels inhibits rotenone-induced neuroinflammation
    Fang Zhou
    Jiangsu Key Laboratory of Neurodegeneration, Department of Anatomy Histology, Pharmacology Nanjing Medical University Nanjing, Jiangsu, P R China
    J Cell Mol Med 12:1559-70. 2008
    ..channel opener pinacidil and selective mitochondrial K(ATP) (mito-K(ATP)) channel opener diazoxide prevented rotenone-induced microglial activation and production of pro-inflammatory factors (tumour necrosis factor[TNF]-alpha and ..
  68. ncbi Mouse model of optic neuropathy caused by mitochondrial complex I dysfunction
    Xian Zhang
    Institute for Neuroscience and Center for Molecular and Cellular Toxicology, University of Texas at Austin, Austin, TX 78712, USA
    Neurosci Lett 326:97-100. 2002
    ..a mouse model of optic neuropathy caused by mitochondrial complex I dysfunction by intravitreal administration of rotenone, a complex I inhibitor, in CBA/J mice...
  69. ncbi A rotenone-sensitive site and H2O2 are key components of hypoxia-sensing in neonatal rat adrenomedullary chromaffin cells
    R J Thompson
    Department of Biology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    Neuroscience 145:130-41. 2007
    ..Here we tested the hypothesis that a rotenone-sensitive O2-sensor and ROS are involved in the hypoxic response of AMC cultured from neonatal and juvenile rats...
  70. ncbi Minocycline protects dopaminergic neurons against long-term rotenone toxicity
    Khaled Radad
    Department of Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt
    Can J Neurol Sci 37:81-5. 2010
    ..In Parkinson's disease, most of current therapies only provide symptomatic treatment and so far there is no drug which directly affects the disease process...
  71. ncbi Human dental pulp stem cells protect mouse dopaminergic neurons against MPP+ or rotenone
    Claudia Nesti
    RRMR CUCCS Rete Regionale di Medicina Rigenerativa Center for the Clinical Use of Stem Cells, Italy Stella Maris Scientific Institute, Pisa, Italy
    Brain Res 1367:94-102. 2011
    ..5, 5, and 10 μM) and rotenone (0.25, 0...
  72. ncbi Neuroprotective effect of the antiparkinsonian drug pramipexole against nigrostriatal dopaminergic degeneration in rotenone-treated mice
    Masatoshi Inden
    Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607 8414, Japan
    Neurochem Int 55:760-7. 2009
    ..study, we examined the effect of pramipexole on DA neurons in a PD model of C57BL/6 mice, which were treated with rotenone (30 mg/kg, p.o.) daily for 28 days. Pramipexole (1 mg/kg, i.p...
  73. ncbi Bax shuttling after rotenone treatment of neuronal primary cultures: effects on cell death phenotypes
    Martin B Gill
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1072, USA
    J Neurosci Res 87:2047-65. 2009
    ..the role of Bax intracellular shuttling ER cell death signaling and necrotic-like cell death, we used rotenone-treated P5 neuronal cortical cultures to increase ER Bax levels and subsequent cell death signaling...
  74. ncbi Rotenone potentiates NMDA currents in substantia nigra dopamine neurons
    Yan Na Wu
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Neurosci Lett 421:96-100. 2007
    b>Rotenone is a pesticide that produces a rodent model of Parkinson's disease...
  75. ncbi Cold stress decreases the capacity for respiratory NADH oxidation in potato leaves
    A Staffan Svensson
    Department of Cell and Organism Biology, HS 4, Lund University, Lund, Sweden
    FEBS Lett 517:79-82. 2002
    ..This decrease is accompanied by specific decreases of immunodetected NDA protein and internal rotenone-insensitive NADH oxidation in mitochondria isolated from cold-treated plants...
  76. ncbi Acute action of rotenone on nigral dopaminergic neurons--involvement of reactive oxygen species and disruption of Ca2+ homeostasis
    Peter S Freestone
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    Eur J Neurosci 30:1849-59. 2009
    b>Rotenone is a toxin used to generate animal models of Parkinson's disease; however, the mechanisms of toxicity in substantia nigra pars compacta (SNc) neurons have not been well characterized. We have investigated rotenone (0...
  77. ncbi The results of five coded compounds: genistein, metaproterenol, rotenone, p-anisidine and resorcinol tested in the pH 6.7 Syrian hamster embryo cell morphological transformation assay
    James S Harvey
    Genetic Toxicology, GlaxoSmithKline, Park Road, Ware, Hertfordshire SG12 0DP, UK
    Mutagenesis 20:51-6. 2005
    ..We selected five compounds, genistein, metaproterenol, rotenone, p-anisidine and resorcinol, that had extensive genotoxicity and carcinogenicity data and tested them in the ..
  78. ncbi Rotenone neurotoxicity: a new window on environmental causes of Parkinson's disease and related brain amyloidoses
    John Q Trojanowski
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Exp Neurol 179:6-8. 2003
  79. ncbi Rotenone partially reverses decreased BK Ca currents in cerebral artery smooth muscle cells from streptozotocin-induced diabetic mice
    Ling Dong
    Department of Physiology, Fourth Military Medical University, Xi an 710032, China
    Clin Exp Pharmacol Physiol 36:e57-64. 2009
    ..p., dissolved in sterile saline). Control and diabetic mice were treated with 12.7 micromol/L rotenone, an inhibitor of the mitochondrial electron transport chain complex I, or placebo every other day for 5 weeks...
  80. ncbi Role and regulation of ferritin H in rotenone-mediated mitochondrial oxidative stress
    Elizabeth L Mackenzie
    Department of Environmental and Molecular Toxicology, North Carolina State University, Campus Box 7633, Raleigh, NC 27695, USA
    Free Radic Biol Med 44:1762-71. 2008
    ..activation of the ferritin H gene in response to the mitochondrial complex I inhibitor and neurotoxic compound rotenone. Rotenone exposure increased ferritin H mRNA and protein synthesis in NIH3T3 fibroblasts and SH-SY5Y ..
  81. ncbi Reversal of rotenone-induced dysfunction of astrocytic connexin43 by opening mitochondrial ATP-sensitive potassium channels
    Shu Zhang
    Department of Pharmacology, Nanjing Medical University, Jiangsu, People s Republic of China
    Cell Mol Neurobiol 31:111-7. 2011
    ..However, little is known about the role of Cx43 in Parkinson's disease (PD). In this article, we report that rotenone, a classic neurotoxin for PD, could inhibit expression of astrocytic Cx43 and gap junction permeability...
  82. ncbi Rotenone induces cell death of cholinergic neurons in an organotypic co-culture brain slice model
    Celine Ullrich
    Laboratory of Psychiatry and Exp Alzheimer s Research, Department of Psychiatry, Innsbruck Medical University, Anichstr 35, 6020 Innsbruck, Austria
    Neurochem Res 34:2147-53. 2009
    ..It is well established that rotenone, an inhibitor of complex I of the electron transport chain, induces cell death of dopaminergic neurons, however, ..
  83. ncbi Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered dopamine metabolism
    Yan Sai
    Department of Preventive Medicine, Third Military Medical University, Chongqing, China
    Toxicol In Vitro 22:1461-8. 2008
    b>Rotenone is a widely used pesticide...
  84. ncbi Purification and characterization of a rotenone-insensitive NADH:Q6 oxidoreductase from mitochondria of Saccharomyces cerevisiae
    S de Vries
    Section for Molecular Biology, University of Amsterdam, The Netherlands
    Eur J Biochem 176:377-84. 1988
    ..for NADH with apparent Km = 31 microM and was found to be inhibited by flavone (I50 = 95 microM), but not by rotenone or piericidin...
  85. ncbi Autophagy protects the rotenone-induced cell death in alpha-synuclein overexpressing SH-SY5Y cells
    Shorafidinkhuja Dadakhujaev
    Department of Biochemistry and Neurobiology and Institute of Health Sciences, Gyeongsang National University School of Medicine, 92 Chilam dong, Jinju, Gyeongnam 660 751, Republic of Korea
    Neurosci Lett 472:47-52. 2010
    ..LC3-II protein, a critical marker for autophagy, was produced in an autophagy-dependent manner. The rotenone-induced cell death was interrupted by autophagy stimulation...
  86. ncbi Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology
    Robert E Drolet
    Pittsburgh Institute for Neurodegenerative Disease, Department of Neurology, University of Pittsburgh, Pittsburgh, PA 1526, USA
    Neurobiol Dis 36:96-102. 2009
    ..To begin to explore these phenomena in laboratory models of PD, rats were treated with either vehicle or rotenone (2.0 mg/kg, i.p.; 5 days/week) for 6-weeks...
  87. ncbi A transient inhibition of mitochondrial ATP synthesis by nitric oxide synthase activation triggered apoptosis in primary cortical neurons
    A Almeida
    , Hospital Universitario de Salamanca, Spain
    J Neurochem 77:676-90. 2001
    ....
  88. ncbi Stress-induced activation of the p53 tumor suppressor in leukemia cells and normal lymphocytes requires mitochondrial activity and reactive oxygen species
    Leonid Karawajew
    Department of Hematology, Oncology, and Tumor Immunology, Robert Rossle Clinic, Helios Klinikum Berlin Buch, Charite Medical School, Berlin, Germany
    Blood 105:4767-75. 2005
    ..Down-regulation of mitochondrial transmembrane potential (MTMP) by inhibitors of electron transport (rotenone, thenoyltrifluoroacetone (TTFA)) and adenosine triphosphate (ATP) synthesis (oligomycin) prevented stress-induced ..
  89. ncbi Potential role of mitochondria in hypoxia sensing by adrenomedullary chromaffin cells
    Josef Buttigieg
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Adv Exp Med Biol 580:79-85; discussion 351-9. 2006
  90. ncbi Processes and components participating in the generation of intrinsic optical signal changes in vitro
    Katharina Buchheim
    Neurologische Klinik und Poliklinik, Charite Universitatsmedizin, Berlin, Germany
    Eur J Neurosci 22:125-32. 2005
    ..05). This suggests a glial participation in signal generation. Rotenone, an inhibitor of mitochondrial complex I, yielded decreased amplitudes of the intrinsic optical signal (27 +/- 7% ..
  91. ncbi Isolation and characterization of complex I, rotenone-sensitive NADH: ubiquinone oxidoreductase, from the procyclic forms of Trypanosoma brucei
    J Fang
    Department of Biochemistry, West Virginia University School of Medicine, Morgantown, WV 26506-9142, USA
    Eur J Biochem 268:3075-82. 2001
    Additional characterization of complex I, rotenone-sensitive NADH:ubiquinone oxidoreductase, in the mitochondria of Trypanosoma brucei brucei has been obtained...
  92. ncbi Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtin
    Tamara Milakovic
    Department of Psychiatry, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    J Biol Chem 280:30773-82. 2005
    ..These findings demonstrate that the presence of mutant huntingtin impairs mitochondrial ATP production through one or more mechanisms that do not directly affect the function of the respiration complexes...
  93. ncbi Oxidative stress caused by blocking of mitochondrial complex I H(+) pumping as a link in aging/disease vicious cycle
    Andrea Dlasková
    Department of Membrane Transport Biophysics, No 75, Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 14220, Czech Republic
    Int J Biochem Cell Biol 40:1792-805. 2008
    ..b>Rotenone caused a 5-fold J(m) increase (AC(50) 2 microM), which was attenuated by uncoupling, membrane potential (DeltaPsi(..
  94. ncbi Depressant effect of mitochondrial respiratory complex inhibitors on proteasome inhibitor-induced mitochondrial dysfunction and cell death in PC12 cells
    Sun Joo Lee
    Department of Pharmacology, College of Medicine, Chung Ang University, 156 756, Seoul, South Korea
    Neurochem Res 30:1191-200. 2005
    The addition of rotenone (inhibitor of respiratory complex I), 3-nitropropionic acid (complex II inhibitor), harmine (inhibitor of complexes I and II) and cyclosporin A (CsA, an inhibitor of the mitochondrial permeability transition) ..
  95. ncbi Mechanism of toxicity of the branched-chain fatty acid phytanic acid, a marker of Refsum disease, in astrocytes involves mitochondrial impairment
    Georg Reiser
    Institut fur Neurobiochemie, Otto von Guericke Universitat Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Int J Dev Neurosci 24:113-22. 2006
    ..Phytanic acid caused cell death of astrocytes within a few hours of exposure. In conclusion, we suggest that phytanic acid initiates astrocyte cell death by activating the mitochondrial route of apoptosis...
  96. ncbi TNF-alpha/cycloheximide-induced apoptosis in intestinal epithelial cells requires Rac1-regulated reactive oxygen species
    Shi Jin
    Dept of Physiology, Univ of Tennessee Health Science Center, 894 Union Ave, Memphis, TN 38163, USA
    Am J Physiol Gastrointest Liver Physiol 294:G928-37. 2008
    ..The antioxidant, N-acetylcysteine (NAC), or rotenone (Rot), the mitochondrial electron transport chain inhibitor, attenuated mitochondrial ROS production and ..
  97. ncbi Protocatechuic acid inhibits apoptosis by mitochondrial dysfunction in rotenone-induced PC12 cells
    Ye Ming Liu
    Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian 116024, China
    Toxicol In Vitro 22:430-7. 2008
    ..However, the mechanism how PCA suppresses rotenone-induced neurotoxicity in cultured PC12 cells remains unclear...
  98. ncbi Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria
    Qun Chen
    Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Physiol Cell Physiol 294:C460-6. 2008
    ..With succinate as substrate in the presence of rotenone, H(2)O(2) increased by 272 +/- 22% and 171 +/- 21% in SSM and IFM, respectively, after ischemia...
  99. ncbi Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells
    Jinghua Jin
    Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    BMC Neurosci 8:67. 2007
    ..b>Rotenone, a specific inhibitor of mitochondrial complex I, has been shown to produce neurodegeneration in rats as well as ..
  100. ncbi Interleukin-5 priming of human eosinophils alters siglec-8 mediated apoptosis pathways
    Esra Nutku-Bilir
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 38:121-4. 2008
    ..Finally, both the mitochondrial electron transport inhibitor rotenone, and the ROS inhibitors diphenyleneiodonium and antimycin, completely inhibited Siglec-8-mediated apoptosis, even ..
  101. ncbi Zaprinast inhibits hydrogen peroxide-induced lysosomal destabilization and cell death in astrocytes
    Jae Hyuck Choi
    Department of Pharmacology, Korea University College of Medicine, 126 1, 5 ga, Anam Dong, Sungbuk Gu, Seoul 136 705, Republic of Korea
    Eur J Pharmacol 571:106-15. 2007
    ..acridine orange relocation and the induced decrease in mitochondrial potential, but zaprinast had no effect on rotenone-induced mitochondrial collapse, which was not associated with lysosomal destabilization...

Research Grants75

  1. FLOW AND METABOLIC TRACER KINETICS IN HEART
    Robert Marshall; Fiscal Year: 2002
    ..b>Rotenone and its analogues are neutral, lipophilic compounds that are potent inhibitors of Complex 1 of the mitochondrial ..
  2. GI Endotoxin as an Environmental Trigger in an alpha-Synuclein Transgenic Mouse
    Robert L Nussbaum; Fiscal Year: 2010
    ..We will expose these transgenic animals to gram-negative endotoxin and rotenone, two agents frequently considered as environmental toxins most strongly implicated in PD...
  3. Proteomic Studies in Parkinson's Disease
    Jing Zhang; Fiscal Year: 2007
    ..A few neurotoxicants, e.g. rotenone, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine, all capable of inhibiting mitochondria and ..
  4. NADH-UBIQUINONE REDUCTASE OF PARACOCCUS DENITRIFICANS
    Takao Yagi; Fiscal Year: 1993
    ..ii) Identification of the DCCD-binding and the rotenone-binding subunit(s) of the Paracoccus NADH dehydrogenase complex...
  5. PROTON & ELECTRON TRANSFER & ENERGY COUPLING
    Tomoko Ohnishi; Fiscal Year: 1992
    ..chemical properties of the H+-carriers, (ii) investigate new inhibitors which are different from conventional rotenone-type compounds, (iii) measure the spatial organization of the redox components in the membrane using continuous ..
  6. Oxidative modification of brain proteins in pesticide intoxication
    PIER MASTROBERARDINO; Fiscal Year: 2007
    ..designed to identify those proteins that get oxidized following the administration of two different pesticides, rotenone or paraquat, and to validate their potential use as biomarkers in antioxidant therapy...
  7. Deep Brain Stimulation in Parkinson's Models
    Marjorie Anderson; Fiscal Year: 2006
    ..In the proposed studies, the ability of chronic administration of the insecticide rotenone, to produce an animal model of Parkinson's disease will first be tested in monkeys...
  8. Mitochondrial Response to Oxidative Stress
    DANIEL BOGENHAGEN; Fiscal Year: 2006
    ..A number of cellular toxins, including rotenone, 1-methyl-4-phenylpyridine (MPP+) and paraquat act to impair mitochondrial electron transport, generating ROS...
  9. Interaction Between Genes and the Mitochondria in Parkin
    Benjamin Wolozin; Fiscal Year: 2007
    ..We will mainly use rotenone as the model toxin for complex I disruption...
  10. Interaction Between Genes and the Mitochondria in Parkin
    Benjamin L Wolozin; Fiscal Year: 2010
    ..We will mainly use rotenone as the model toxin for complex I disruption...
  11. Endoplasmic Reticulum Stress and Parkinson's Disease
    David Ron; Fiscal Year: 2004
    ..Recent experiments from our lab indicate that 6-hydroxydopamine and Rotenone, toxins implicated in experimental and environmental PD, cause an imbalance between the folding capacity of the ..
  12. Mitochondrial Oxidative Stress and Protection in Pesticide-induced Neurotoxicity
    Jiyang Cai; Fiscal Year: 2007
    ..In animal models, selective toxicities to the nigrostriatal dopaminergic neurons occur after systemic exposure to rotenone and paraquat. Oxidative stress is a common mediator of pesticide-induced neurotoxicity...
  13. Calpain inhibitors in models of Parkinson's disease
    Michel Baudry; Fiscal Year: 2007
    ..against MPTP-mediated neurotoxicity and behavioral impairments in vivo in C57BI/6 mice, and against rotenone-mediated neurotoxicity in rats...
  14. Metabolic Oxidative Stress in Human Cancer Cells
    Douglas Spitz; Fiscal Year: 2007
    ..Specific Aim 1 will determine using electron transport chain blockers (i.e., antimycin A, myxothiazol, and rotenone), if intact human cancer cells (or isolated mitochondria) demonstrate alterations in ROS production by ..
  15. Metabolic Oxidative Stress in Human Cancer Cells
    Douglas Spitz; Fiscal Year: 2007
    ..Specific Aim 1 will determine using electron transport chain blockers (i.e., antimycin A, myxothiazol, and rotenone), if intact human cancer cells (or isolated mitochondria) demonstrate alterations in ROS production by ..
  16. Dopamine, mutant synuclein, oxidative stress and inflammation
    Howard J Federoff; Fiscal Year: 2010
    ..Efforts to elucidate thls mechanism have been aided by the linkage between toxicant (e.g., MPTP, paraquat. rotenone) injury, oxidative stress, inherited defects in turnover of the presynaptic and Lewy Body constituent protein a-..
  17. GENETICS OF MPTP-INDUCED PARKINSONISM
    Richard Smeyne; Fiscal Year: 2009
    ..blockade or transfer of GSTpi on cell death following administration of MPTP in vitro and in vivo; 3) Develop the rotenone model of experimental Parkinsonism in mice and determine if GSTp2 is altered in response to rotenone; 4) ..
  18. HEAT AND RADIATION EFFECTS ON TUMOR MICROCIRCULATION
    Mark Dewhirst; Fiscal Year: 2000
    ..Thus, we will determine how reduction in 02 consumption (induced by hypothermia, hyperglycemia, rotenone or metronidazole) or increase in blood 02 content (using carbogen, 100% 02, or hyperbaric 02) alone or in ..
  19. GENETICS OF MPTP-INDUCED PARKINSONISM
    Richard Smeyne; Fiscal Year: 2007
    ..blockade or transfer of GSTpi on cell death following administration of MPTP in vitro and in vivo; 3) Develop the rotenone model of experimental Parkinsonism in mice and determine if GSTp2 is altered in response to rotenone; 4) ..
  20. Mitochondrial Metabiolites to Treat Parkinson's Disease
    Bruce Ames; Fiscal Year: 2005
    ..our hypothesis using behavioral, biochemical, and immunohistochemical techniques on two models of PD: the chronic rotenone-exposed SK-N-MC human neuroblastoma cell model and the chronic rotenone-treated rat model...