rotenone

Summary

Summary: A botanical insecticide that is an inhibitor of mitochondrial electron transport.

Top Publications

  1. pmc Rotenone, paraquat, and Parkinson's disease
    Caroline M Tanner
    The Parkinson s Institute, Sunnyvale, California 94085, USA
    Environ Health Perspect 119:866-72. 2011
  2. ncbi Production of reactive oxygen species by mitochondria: central role of complex III
    Qun Chen
    Department of Medicine, Division of Cardiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 278:36027-31. 2003
  3. doi Potential autophagy enhancers attenuate rotenone-induced toxicity in SH-SY5Y
    N Xiong
    Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei 430022, China
    Neuroscience 199:292-302. 2011
  4. ncbi Topology of superoxide production from different sites in the mitochondrial electron transport chain
    Julie St-Pierre
    MRC Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, England
    J Biol Chem 277:44784-90. 2002
  5. pmc Pretreatment with near-infrared light via light-emitting diode provides added benefit against rotenone- and MPP+-induced neurotoxicity
    Rong Ying
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Brain Res 1243:167-73. 2008
  6. ncbi Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons
    Hui Ming Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Neurosci 23:6181-7. 2003
  7. ncbi Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production
    Nianyu Li
    Purdue University Cytometry Laboratories, Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 278:8516-25. 2003
  8. pmc Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice
    Francisco Pan-Montojo
    Institute of Anatomy, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
    PLoS ONE 5:e8762. 2010
  9. ncbi Rotenone-induced apoptosis is mediated by p38 and JNK MAP kinases in human dopaminergic SH-SY5Y cells
    Kathleen Newhouse
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195 7234, USA
    Toxicol Sci 79:137-46. 2004
  10. pmc Involvement of p53 in cell death following cell cycle arrest and mitotic catastrophe induced by rotenone
    António Pedro Gonçalves
    IBMC Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
    Biochim Biophys Acta 1813:492-9. 2011

Research Grants

Detail Information

Publications290 found, 100 shown here

  1. pmc Rotenone, paraquat, and Parkinson's disease
    Caroline M Tanner
    The Parkinson s Institute, Sunnyvale, California 94085, USA
    Environ Health Perspect 119:866-72. 2011
    ..Certain pesticides may affect these mechanisms, but no pesticide has been definitively associated with PD in humans...
  2. ncbi Production of reactive oxygen species by mitochondria: central role of complex III
    Qun Chen
    Department of Medicine, Division of Cardiology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 278:36027-31. 2003
    ..Limitation of electron transport by the inhibitor rotenone immediately before ischemia decreases the production of ROS in cardiac myocytes and reduces damage to ..
  3. doi Potential autophagy enhancers attenuate rotenone-induced toxicity in SH-SY5Y
    N Xiong
    Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei 430022, China
    Neuroscience 199:292-302. 2011
    ..2 μM) or lithium (LiCl, 10 mM) significantly enhanced cell viability, decreased rotenone-induced nuclear fragmentation and apoptosis, ameliorated the decrease in mitochondrial membrane potential, ..
  4. ncbi Topology of superoxide production from different sites in the mitochondrial electron transport chain
    Julie St-Pierre
    MRC Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, England
    J Biol Chem 277:44784-90. 2002
    ..However, when complex I was fully reduced using rotenone, rat mitochondria released significantly more hydrogen peroxide than pigeon mitochondria...
  5. pmc Pretreatment with near-infrared light via light-emitting diode provides added benefit against rotenone- and MPP+-induced neurotoxicity
    Rong Ying
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Brain Res 1243:167-73. 2008
    ..The present study used these specific mitochondrial complex I inhibitors (rotenone and 1-methyl-4-phenylpyridinium or MPP(+)) on striatal and cortical neurons in culture...
  6. ncbi Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons
    Hui Ming Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Neurosci 23:6181-7. 2003
    ..Chronic exposure to rotenone, a common herbicide, reproduces features of Parkinsonism in rats...
  7. ncbi Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production
    Nianyu Li
    Purdue University Cytometry Laboratories, Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 278:8516-25. 2003
    Inhibition of mitochondrial respiratory chain complex I by rotenone had been found to induce cell death in a variety of cells. However, the mechanism is still elusive...
  8. pmc Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice
    Francisco Pan-Montojo
    Institute of Anatomy, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
    PLoS ONE 5:e8762. 2010
    ..Here we report that intragastrically administered rotenone, a commonly used pesticide that inhibits Complex I of the mitochondrial respiratory chain, is able to reproduce ..
  9. ncbi Rotenone-induced apoptosis is mediated by p38 and JNK MAP kinases in human dopaminergic SH-SY5Y cells
    Kathleen Newhouse
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195 7234, USA
    Toxicol Sci 79:137-46. 2004
    b>Rotenone is a naturally derived pesticide that has recently been shown to evoke the behavioral and pathological symptoms of Parkinson's disease in animal models...
  10. pmc Involvement of p53 in cell death following cell cycle arrest and mitotic catastrophe induced by rotenone
    António Pedro Gonçalves
    IBMC Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
    Biochim Biophys Acta 1813:492-9. 2011
    In order to investigate the cell death-inducing effects of rotenone, a plant extract commonly used as a mitochondrial complex I inhibitor, we studied cancer cell lines with different genetic backgrounds...
  11. ncbi Rotenone inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding
    Pallavi Srivastava
    School of Biosciences and Bioengineering, Indian Institute of Technology, Mumbai, India
    FEBS J 274:4788-801. 2007
    b>Rotenone, a widely used insecticide, has been shown to inhibit mammalian cell proliferation and to depolymerize cellular microtubules...
  12. pmc Neonatal exposure to lipopolysaccharide enhances vulnerability of nigrostriatal dopaminergic neurons to rotenone neurotoxicity in later life
    Lir Wan Fan
    Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Neurobiol Dis 44:304-16. 2011
    ..By P70, when LPS-induced behavioral deficits were spontaneously recovered, animals were challenged with rotenone, a commonly used pesticide, through subcutaneous mini-pump infusion at a dose of 1.25 mg/kg per day for 14 days...
  13. pmc Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease
    James G Greene
    Department of Neurology, Emory University School of Medicine, 505H Whitehead Biomedical Research Bldg, 615 Michael St, Atlanta, GA 30322, USA
    Exp Neurol 218:154-61. 2009
    ..We report that the parkinsonian neurotoxin and mitochondrial complex I inhibitor rotenone causes delayed gastric emptying and enteric neuronal dysfunction when administered chronically to rats in the ..
  14. ncbi Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation
    Todd B Sherer
    Center for Neurodegenerative Disease, Department of Neurology, Emory University, Atlanta, GA 30032, USA
    Exp Neurol 179:9-16. 2003
    Previous studies demonstrated that chronic systemic exposure to the pesticide and mitochondrial toxin rotenone through jugular vein cannulation reproduced many features of Parkinson's disease (PD) in rats, including nigrostriatal ..
  15. ncbi Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures
    Claudia M Testa
    Center for Neurodegenerative Disease, Emory University, Atlanta, GA 30322, USA
    Brain Res Mol Brain Res 134:109-18. 2005
    b>Rotenone, a pesticide and complex I inhibitor, causes nigrostriatal degeneration similar to Parkinson disease pathology in a chronic, systemic, in vivo rodent model [M. Alam, W.J...
  16. pmc Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity
    H L Liang
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuroscience 153:963-74. 2008
    ..The current study tested our hypothesis that LED treatment can protect neurons from both rotenone- and MPP(+)-induced neurotoxicity...
  17. pmc Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat
    Won Seok Choi
    Toxicology Program, Department of Environmental and Occupational Health Sciences, Graduate Program in Neurobiology and Behavior, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195 7234, USA
    Proc Natl Acad Sci U S A 105:15136-41. 2008
    ..Although dopaminergic neurons were more sensitive than other neurons in these cultures to cell death induced by rotenone, MPP(+), or paraquat treatments, the absence of complex I activity did not protect the dopaminergic neurons, as ..
  18. ncbi Rotenone-induced G2/M cell cycle arrest and apoptosis in a human B lymphoma cell line PW
    J S Armstrong
    Department of Radiation Oncology, Stanford University Medical Center, Stanford, California 94305 5105, USA
    Biochem Biophys Res Commun 289:973-8. 2001
    Concentrations of rotenone (ROT) that block electron flow through mitochondrial complex I (100 nM) did not significantly alter either cell viability or the growth of PW cells...
  19. doi Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: involvement of alpha-synuclein
    Barbara Monti
    Department of Biology, University of Bologna, Bologna, Italy
    Neurotox Res 17:130-41. 2010
    ..of nigro-striatal dopaminergic neurons is obtained through sub-chronic administration of the mitochondrial toxin, rotenone, via osmotic mini pumps implanted to rats...
  20. doi Hydrogen sulfide inhibits rotenone-induced apoptosis via preservation of mitochondrial function
    Li Fang Hu
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Mol Pharmacol 75:27-34. 2009
    ..The present study was undertaken to investigate the effects of H(2)S on cell injury induced by rotenone, a commonly used toxin in establishing in vivo and in vitro Parkinson's disease (PD) models, in human-derived ..
  21. ncbi Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease
    Todd B Sherer
    Center for Neurodegenerative Disease, Rollins School of Public Health, Atlanta, Georgia 15213, USA
    J Neurochem 100:1469-79. 2007
    Parkinson's disease (PD) has been linked to mitochondrial dysfunction and pesticide exposure. The pesticide rotenone (ROT) inhibits complex I and reproduces features of PD in animal models, suggesting that environmental agents that ..
  22. doi Rotenone induces apoptosis in MCF-7 human breast cancer cell-mediated ROS through JNK and p38 signaling
    Yea Tzy Deng
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Mol Carcinog 49:141-51. 2010
    b>Rotenone is an inhibitor of the mitochondrial electron transport chain complex I, resulting in the generation of reactive oxygen species (ROS)...
  23. ncbi Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone
    Masatoshi Inden
    Department of Neurobiology and 21st Century COE Program, Kyoto Pharmaceutical University, Kyoto, Japan
    J Neurochem 101:1491-1504. 2007
    ..Previous studies have demonstrated that chronic systemic exposure of Lewis rats to rotenone produced many features of PD, and cerebral tauopathy was also detected in the case of severe weight loss...
  24. pmc JNK3 mediates paraquat- and rotenone-induced dopaminergic neuron death
    Won Seok Choi
    Toxicology Program in the Department of Environmental and Occupational Health Sciences, Graduate Program in Neurobiology and Behavior, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, USA
    J Neuropathol Exp Neurol 69:511-20. 2010
    ..kinase 3 (JNK3), a neural-specific JNK isoform, in dopaminergic neuron death induced by the pesticides rotenone and paraquat. The role of JNK3 was evaluated using RNA silencing and gene deletion to block JNK3 signaling...
  25. ncbi Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons
    Hui Ming Gao
    Neuropharmacology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Neurosci 22:782-90. 2002
    ..In experimental animals the exposure to a common herbicide, rotenone, induces features of parkinsonism; mechanistically, rotenone-induced destruction of dopaminergic neurons has been ..
  26. pmc Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation
    Kristina Leuner
    Department of Pharmacology, ZAFES, Biocenter, University of Frankfurt, Frankfurt Main, Germany
    Antioxid Redox Signal 16:1421-33. 2012
    ..We asked whether mitochondrion-derived reactive oxygen species (ROS) are sufficient to increase Aβ generation and thereby initiate a vicious cycle further impairing mitochondrial function...
  27. ncbi Apoptosis induction by the natural product cancer chemopreventive agent deguelin is mediated through the inhibition of mitochondrial bioenergetics
    N Hail
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Apoptosis 9:437-47. 2004
    ..These results demonstrate that deguelin induces apoptosis in skin cancer cells by inhibiting mitochondrial bioenergetics and provide a novel mechanism for the putative anticancer activity of this agent...
  28. ncbi Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity
    K W Leung
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong
    Neuropharmacology 52:827-35. 2007
    ..isolated from ginseng, demonstrated neuroprotective effects on primary cultured rat nigral neurons against rotenone toxicity...
  29. pmc Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice
    Francisco Pan-Montojo
    Institute for Anatomy, TU Dresden, Fetscherstr 74, 01307, Dresden, Germany
    Sci Rep 2:898. 2012
    ..Moreover, our results show that an environmental toxin (i.e. rotenone) promotes the release of alpha-synuclein by enteric neurons and that released enteric alpha-synuclein is up-taken ..
  30. doi Effects of rotenone and pyridaben on complex I electron transfer and on mitochondrial nitric oxide synthase functional activity
    Ana Navarro
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cadiz, Plaza Fragela 9, 11003 Cadiz, Spain
    J Bioenerg Biomembr 42:405-12. 2010
    b>Rotenone and pyridaben were tested on activities and properties of rat brain mitochondria determining Ki (inhibitor concentration at half maximal inhibition) and Imax (% of inhibition at maximal inhibitor concentration)...
  31. ncbi Increased striatal dopamine turnover following acute administration of rotenone to mice
    C Thiffault
    The Parkinson s Institute, Sunnyvale, CA 94089, USA
    Brain Res 885:283-8. 2000
    ..potential role of mitochondrial dysfunction in nigrostriatal degeneration in Parkinson's disease, the effects of rotenone (an inhibitor of mitochondrial NADH dehydrogenase and a naturally occurring toxicant) on the levels of striatal ..
  32. ncbi Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease
    Jinghua Jin
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Mol Cell Proteomics 5:1193-204. 2006
    ..Manipulations of mortalin level in dopaminergic neurons resulted in significant changes in sensitivity to PD phenotypes via pathways involving mitochondrial and proteasomal function as well as oxidative stress...
  33. ncbi Selective microglial activation in the rat rotenone model of Parkinson's disease
    Todd B Sherer
    Center for Neurodegenerative Disease, Emory University, 30322, Atlanta, GA, USA
    Neurosci Lett 341:87-90. 2003
    Chronic rotenone exposure reproduces features of Parkinson's disease (PD) (Nat. Neurosci. 3 (2000) 1301; Exp. Neurol. 179 (2003) 9). We investigated the role of glial activation in rotenone toxicity in vivo...
  34. doi Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models
    Hiroki Takeuchi
    Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Neurosci Res 87:576-85. 2009
    ..To assess the protective effect of nicotine against rotenone-induced DA neuronal cell toxicity, we examined the neuroprotective effects of nicotine in rotenone-induced PD ..
  35. pmc Free tubulin modulates mitochondrial membrane potential in cancer cells
    Eduardo N Maldonado
    Center for Cell Death, Injury and Regeneration, Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina, USA
    Cancer Res 70:10192-201. 2010
    ..Microtubule destabilizers, rotenone, colchicine, and nocodazole, and the microtubule stabilizer paclitaxel increased and decreased cellular free ..
  36. ncbi Parkinsonian rotenone mouse model: reevaluation of long-term administration of rotenone in C57BL/6 mice
    Masatoshi Inden
    Department of Neurobiology, Kyoto Pharmaceutical University, Japan
    Biol Pharm Bull 34:92-6. 2011
    Chronic systemic exposure of Lewis rats to rotenone produced many features of Parkinson's disease (PD), including nigrostriatal dopamine (DA) neurodegeneration and the formation of cytoplasmic inclusions in nigral DA neurons...
  37. doi Opening of microglial K(ATP) channels inhibits rotenone-induced neuroinflammation
    Fang Zhou
    Jiangsu Key Laboratory of Neurodegeneration, Department of Anatomy Histology, Pharmacology Nanjing Medical University Nanjing, Jiangsu, P R China
    J Cell Mol Med 12:1559-70. 2008
    ..channel opener pinacidil and selective mitochondrial K(ATP) (mito-K(ATP)) channel opener diazoxide prevented rotenone-induced microglial activation and production of pro-inflammatory factors (tumour necrosis factor[TNF]-alpha and ..
  38. doi Pesticide/environmental exposures and Parkinson's disease in East Texas
    Amanpreet S Dhillon
    Department of Occupational Health Sciences, University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    J Agromedicine 13:37-48. 2008
    ..is little human data on risk associated with specific pesticide products, including organic pesticides such as rotenone with PD...
  39. doi Rapamycin protects against rotenone-induced apoptosis through autophagy induction
    T Pan
    Parkinson Disease Research Laboratory, Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuroscience 164:541-51. 2009
    ..Mitochondrial complex I inhibitor rotenone, which causes dysfunction mitochondria and UPS, has been considered as one of the neurotoxins related to PD...
  40. pmc Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts
    Heather Mortiboys
    Academic Neurology Unit, Medical School, University of Sheffield, Sheffield, United Kingdom
    Ann Neurol 64:555-65. 2008
    ..The aim of our study was to determine mitochondrial function and morphology in parkin-mutant patients. We also investigated whether pharmacological rescue of impaired mitochondrial function may be possible in parkin-mutant human tissue...
  41. ncbi Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease
    Marc Meulener
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Curr Biol 15:1572-7. 2005
    ..however, they display a striking selective sensitivity to those environmental agents, including paraquat and rotenone, linked to PD in humans...
  42. ncbi Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity after partial respiratory inhibition of mitochondrial complex I with rotenone
    Nagendra Yadava
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurosci 27:7310-7. 2007
    Partial inhibition of mitochondrial respiratory complex I by rotenone reproduces aspects of Parkinson's disease in rodents...
  43. ncbi Redox-dependent modulation of aconitase activity in intact mitochondria
    Anne Laure Bulteau
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106 4970, USA
    Biochemistry 42:14846-55. 2003
    ....
  44. pmc Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species
    Romana Fato
    Dipartimento di Biochimica G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Biochim Biophys Acta 1787:384-92. 2009
    ..Our results indicate that different Complex I inhibitors can be grouped into two classes: Class A inhibitors (Rotenone, Piericidin A and Rolliniastatin 1 and 2) increase ROS production; Class B inhibitors (Stigmatellin, Mucidin, ..
  45. pmc Neuronal expression of a single-subunit yeast NADH-ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan
    Sepehr Bahadorani
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095 1527, USA
    Aging Cell 9:191-202. 2010
    ..These findings are consistent with the idea that enhanced respiratory chain activity in neuronal tissue can prolong fly lifespan...
  46. ncbi Leber hereditary optic neuropathy mtDNA mutations disrupt glutamate transport in cybrid cell lines
    Simone Beretta
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, San Gerardo Hospital, Monza, MI, Italy
    Brain 127:2183-92. 2004
    ..This observation is particularly relevant since EAAT1 is the major means of glutamate removal in the inner retina and this prevents retinal ganglion cells being damaged as a result of excitotoxicity...
  47. pmc Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells
    Shaik Shavali
    Department of Pathology, University of North Dakota, School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58202, USA
    Neurosci Lett 439:125-8. 2008
    ..HEK-syn cells); and whether alpha-syn overexpression causes cells to be more vulnerable to mitochondrial toxin, rotenone. Western blotting and confocal microscopy techniques were employed to assess localization of alpha-syn in the ..
  48. ncbi Rotenone induces cell death in primary dopaminergic culture by increasing ROS production and inhibiting mitochondrial respiration
    Khaled Radad
    Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt
    Neurochem Int 49:379-86. 2006
    ..from embryonic mouse mesencephala were applied to investigate the toxic effects and underlying mechanisms of rotenone-induced neuronal cell death relevant to Parkinson's disease...
  49. doi DJ-1 protects dopaminergic neurons against rotenone-induced apoptosis by enhancing ERK-dependent mitophagy
    H Gao
    Beijing Institute for Neuroscience, Capital Medical University, Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Center of Neural Regeneration and Repair, Beijing Key Laboratory of Brain Major Disorders State Key Lab Incubation Base, Beijing Neuroscience Disciplines, Beijing 100069, China
    J Mol Biol 423:232-48. 2012
    ..Cultured DA cells (MN9D) overexpressing DJ-1 were treated with the mitochondrial complex I inhibitor, rotenone. In addition, rotenone was injected into the left substantia nigra of rats 4weeks after injection with a DJ-1 ..
  50. pmc Ceruloplasmin protects against rotenone-induced oxidative stress and neurotoxicity
    Akiyo Hineno
    Department of Medicine Neurology and Rheumatology, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Neurochem Res 36:2127-35. 2011
    ..mice on the C57BL/10 genetic background and further treated them with a mitochondrial complex I inhibitor, rotenone. There was no iron accumulation in the brains of CP⁻/⁻ mice at least up to 60 weeks of age...
  51. ncbi Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion
    Asha S Nair
    Department of Experimental Therapeutics, Cytokine Research Laboratory, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 177:5612-22. 2006
    ..Our results demonstrate that deguelin inhibits the NF-kappaB activation pathway, which may explain its role in the suppression of carcinogenesis and cellular proliferation...
  52. ncbi Prostaglandin A1 inhibits rotenone-induced apoptosis in SH-SY5Y cells
    Xiaoxia Wang
    National Institute of Neurological Disorders and Stroke, Experimental Therapeutics Branch, Bethesda, Maryland, USA
    J Neurochem 83:1094-102. 2002
    ..an inducer of heat shock proteins (HSPs), we exposed human dopaminergic SH-SY5Y cells to the complex I inhibitor rotenone. Dose-dependent apoptosis was preceded by the nuclear translocation of NF-kappaB and then the activation of ..
  53. pmc Protein aggregation containing β-amyloid, α-synuclein and hyperphosphorylated τ in cultured cells of hippocampus, substantia nigra and locus coeruleus after rotenone exposure
    Rodrigo S Chaves
    Department of Neurology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    BMC Neurosci 11:144. 2010
    ..5, 1, 10 and 25 nM of rotenone, which is an agricultural pesticide, for 48 hours.
  54. pmc Parkin protects dopaminergic neurons against microtubule-depolymerizing toxins by attenuating microtubule-associated protein kinase activation
    Yong Ren
    Department of Physiology and Biophysics, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 284:4009-17. 2009
    ..prevented parkin from protecting midbrain dopaminergic neurons against microtubule-depolymerizing toxins such as rotenone or colchicine...
  55. pmc Identification of AtNDI1, an internal non-phosphorylating NAD(P)H dehydrogenase in Arabidopsis mitochondria
    Catherine S Moore
    School of Biological Sciences, Flinders University of South Australia, GPO Box 2100, Adelaide, South Australia 5001, Australia
    Plant Physiol 133:1968-78. 2003
    ..the capacity for matrix NAD(P)H oxidation via the rotenone-insensitive pathway is significantly reduced in the Atndi1 mutant plant line, and (c)...
  56. pmc Down-regulation of inhibitor of apoptosis proteins by deguelin selectively induces apoptosis in breast cancer cells
    Xiang Hong Peng
    Department of Surgery, Winship Cancer Institute, Emory University School of Medicine, Clinic C, Room C 4088, 1365 C Clifton Road, NE Atlanta, GA 30322, USA
    Mol Pharmacol 71:101-11. 2007
    ....
  57. ncbi Paraquat neurotoxicity is distinct from that of MPTP and rotenone
    Jason R Richardson
    Center for Neurodegenerative Disease, School of Medicine and Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Toxicol Sci 88:193-201. 2005
    Paraquat, MPTP, and rotenone reproduce features of Parkinson's disease (PD) in experimental animals...
  58. ncbi Identification of novel antiangiogenic anticancer activities of deguelin targeting hypoxia-inducible factor-1 alpha
    Seung Hyun Oh
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 122:5-14. 2008
    ..Considering that HIF-1alpha is overexpressed in a majority of human cancers, deguelin could offer a potent therapeutic agent for cancer...
  59. pmc Rotenone prevents impact-induced chondrocyte death
    Wendy Goodwin
    Department of Orthopaedics and Rehabilitation, 1182 ML, The University of Iowa, 500 Newton Rd, Iowa City, Iowa 52242, USA
    J Orthop Res 28:1057-63. 2010
    ..Most positive cells were found within and near areas contacted directly by the impact platen. Rotenone, an electron transport chain inhibitor, was used to test the hypothesis that mitochondria contribute to ..
  60. ncbi Homologues of yeast and bacterial rotenone-insensitive NADH dehydrogenases in higher eukaryotes: two enzymes are present in potato mitochondria
    A G Rasmusson
    Department of Plant Physiology, Lund University, Sweden
    Plant J 20:79-87. 1999
    Two different cDNAs, homologous to genes for rotenone-insensitive NADH dehydrogenases of bacteria and yeast, were isolated from potato...
  61. pmc Epigallocatechin gallate (EGCG) potentiates the cytotoxicity of rotenone in neuroblastoma SH-SY5Y cells
    Woon Gye Chung
    Department of Chemistry, Oregon State University Corvallis, Oregon 97331, USA
    Brain Res 1176:133-42. 2007
    Exposure to rotenone, a widely used pesticide, has been suggested to increase the risk of developing Parkinson's disease...
  62. doi Induction of apoptotic erythrocyte death by rotenone
    Adrian Lupescu
    Department of Physiology, University of Tuebingen, Gmelinstrasse 5, 72076 Tuebingen, Germany
    Toxicology 300:132-7. 2012
    The pesticide rotenone stimulates apoptosis and rotenone intoxication has been considered a cause of Parkinson's disease. Rotenone further sensitizes tumor cells to cytotoxic drugs...
  63. doi D2/D3 receptor agonist ropinirole protects dopaminergic cell line against rotenone-induced apoptosis through inhibition of caspase- and JNK-dependent pathways
    Sheng Chen
    Department of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
    FEBS Lett 582:603-10. 2008
    ..We showed that ropinirole can prevent rotenone-induced apoptosis in dopaminergic cell line SH-SY5Y through D3 receptor...
  64. pmc Dual functionality of myeloperoxidase in rotenone-exposed brain-resident immune cells
    Chi Young Chang
    Branches of Immune and Cell Therapy, National Cancer Center, Goyang, South Korea
    Am J Pathol 179:964-79. 2011
    b>Rotenone exposure has emerged as an environmental risk factor for inflammation-associated neurodegenerative diseases. However, the underlying mechanisms responsible for the harmful effects of rotenone in the brain remain poorly understood...
  65. doi α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment
    Sonia George
    Department of Pathology, The University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia
    J Mol Neurosci 42:243-54. 2010
    ..Since treatment of rodents with the pesticide rotenone can reproduce nigrostriatal cell loss and other features of PD, we aimed to test chronic oral administration of ..
  66. ncbi Hypertonic induction of COX-2 in collecting duct cells by reactive oxygen species of mitochondrial origin
    Tianxin Yang
    Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah 84148, USA
    J Biol Chem 280:34966-73. 2005
    ..to hypertonic treatment were completely blocked by any one of the mitochondrial inhibitors tested, such as rotenone, thenoyltrifluoroacetone, or carbonyl cyanide m-chlorophenylhydrazone, associated with remarkable inhibition of ..
  67. doi Attenuation of rotenone-induced mitochondrial oxidative damage and neurotoxicty in Drosophila melanogaster supplemented with creatine
    Ravikumar Hosamani
    Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Council of Scientific and Industrial Research, Mysore, India
    Neurochem Res 35:1402-12. 2010
    ..This study investigated the neuroprotective effects of Cr against rotenone induced oxidative stress, mortality and neurotoxicty in Drosophila melanogaster...
  68. ncbi Possible involvement of both mitochondria- and endoplasmic reticulum-dependent caspase pathways in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells
    Yoshihisa Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Neurosci Lett 333:25-8. 2002
    Recently, it has been shown that rotenone, a specific inhibitor of mitochondrial complex I, is a useful tool in animal models of Parkinson's disease, but the mechanism of rotenone-induced neuronal death is not fully understood...
  69. doi Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice
    Yoshinori Hayashi
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurosci 28:8624-34. 2008
    ..We herein report that an overexpression of TFAM in HeLa cells significantly inhibited rotenone-induced mitochondrial ROS generation and the subsequent NF-kappaB (nuclear factor-kappaB) nuclear translocation...
  70. ncbi Role of nitric oxide in rotenone-induced nigro-striatal injury
    Yi He
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurochem 86:1338-45. 2003
    b>Rotenone, a widely used pesticide, causes a syndrome in rats that mimics, both behaviorally and pathologically, the symptoms of Parkinson's disease...
  71. ncbi The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy
    Günter U Höglinger
    INSERM U679, Hopital de la Salpetriere, Paris, France
    J Neurochem 95:930-9. 2005
    ..on the distribution of alpha-synuclein or tau, we infused rats systemically with the plant-derived isoflavonoid rotenone. Rotenone-treated rats with a pronounced metabolic impairment had reduced locomotor activity, dystonic limb ..
  72. doi Depressive-like behaviors alterations induced by intranigral MPTP, 6-OHDA, LPS and rotenone models of Parkinson's disease are predominantly associated with serotonin and dopamine
    Ronise M Santiago
    Laboratorio de Fisiologia e Farmacologia do Sistema Nervoso Central, Departamento de Farmacologia, Universidade Federal do Parana, Curitiba, PR, Brasil
    Prog Neuropsychopharmacol Biol Psychiatry 34:1104-14. 2010
    ..1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 6-hydroxydopamine (6-OHDA), lipopolysaccharide (LPS) and rotenone are able to induce depressive-like behaviors and neurotransmitters alterations similarly that encountered in PD...
  73. ncbi Mechanism for generation of hydrogen peroxide and change of mitochondrial membrane potential during rotenone-induced apoptosis
    Saeko Tada-Oikawa
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu Shi, Mie, 514 8507, Japan
    Life Sci 73:3277-88. 2003
    b>Rotenone, an inhibitor of NADH dehydrogenase complex, is a naturally occurring insecticide, which is capable of inducing apoptosis...
  74. doi Long-term efficacy and safety of human umbilical cord mesenchymal stromal cells in rotenone-induced hemiparkinsonian rats
    Nian Xiong
    Department of Neurology, Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, People s Republic of China
    Biol Blood Marrow Transplant 16:1519-29. 2010
    ..effects of human umbilical cord mesenchymal stromal cells (HUMSCs) 1 year after transplantation into rotenone-induced hemiparkinsonian rats...
  75. doi The effect of antiparkinsonian drugs on oxidative stress induced pathological [3H]dopamine efflux after in vitro rotenone exposure in rat striatal slices
    Elisaveta Milusheva
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H 1083 Budapest, Szigony u 43, Hungary
    Neuropharmacology 58:816-25. 2010
    ..60 min rotenone (0...
  76. ncbi Mitochondrial complex I inhibitor rotenone-elicited dopamine redistribution from vesicles to cytosol in human dopaminergic SH-SY5Y cells
    Masahiko Watabe
    Department of Pharmacology, Teikyo University School of Medicine, Tokyo, Japan
    J Pharmacol Exp Ther 323:499-507. 2007
    ..b>Rotenone, a pesticide, produces selective degeneration of dopaminergic neurons and motor dysfunction in rats...
  77. pmc The parkinsonian neurotoxin rotenone activates calpain and caspase-3 leading to motoneuron degeneration in spinal cord of Lewis rats
    S Samantaray
    Department of Neurosciences, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 309 CSB, P O Box 250606, Charleston, SC 29425, USA
    Neuroscience 146:741-55. 2007
    ..b>Rotenone is a neurotoxin that has been used to induce experimental Parkinsonism in rats...
  78. ncbi Coenzyme Q cytoprotective mechanisms for mitochondrial complex I cytopathies involves NAD(P)H: quinone oxidoreductase 1(NQO1)
    Tom S Chan
    Faculty of Pharmacy, University of Toronto, Ont, Canada
    Free Radic Res 36:421-7. 2002
    ..as a model cell, we have shown for the first time that the cytotoxicity caused by complex I inhibition by rotenone but not that caused by complex III inhibition by antimycin can be prevented by coenzyme Q (CoQ1) or menadione...
  79. ncbi Mechanism of toxicity in rotenone models of Parkinson's disease
    Todd B Sherer
    Center for Neurodegenerative Disease, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 23:10756-64. 2003
    Exposure of rats to the pesticide and complex I inhibitor rotenone reproduces features of Parkinson's disease, including selective nigrostriatal dopaminergic degeneration and alpha-synuclein-positive cytoplasmic inclusions (Betarbet et al...
  80. doi Metabolic profiles show specific mitochondrial toxicities in vitro in myotube cells
    Qiuwei Xu
    Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486, USA
    J Biomol NMR 49:207-19. 2011
    ..the application of quantitative NMR metabolomics to in vitro myotube cells treated with mitochondrial toxicants, rotenone and antimycin A...
  81. doi Effects of insulin-like growth factor-1 on rotenone-induced apoptosis in human lymphocyte cells
    Isabel Cristina Avila-Gomez
    School of Medicine, Medical Research Institute, Neuroscience Research Program, University of Antioquia, Medellin, Colombia
    Basic Clin Pharmacol Toxicol 106:53-61. 2010
    ..The present work shows that rotenone, a mitochondrial complex I inhibitor, induced time- and concentration-dependent apoptosis in lymphocytes which ..
  82. pmc Stereotaxical infusion of rotenone: a reliable rodent model for Parkinson's disease
    Nian Xiong
    Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China
    PLoS ONE 4:e7878. 2009
    ..we developed a rat model by stereotaxically (ST) infusing small doses of the mitochondrial complex-I inhibitor, rotenone, into two brain sites: the right ventral tegmental area and the substantia nigra...
  83. ncbi Protective effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline against dopaminergic neurodegeneration in the extrapyramidal structures produced by intracerebral injection of rotenone
    Lucyna Antkiewicz-Michaluk
    Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, Poland
    Int J Neuropsychopharmacol 7:155-63. 2004
    The aim of this paper was to investigate whether rotenone, a pesticide causing experimental parkinsonism, causes direct damage to dopaminergic structure when injected intracerebrally and whether this action may be prevented by peripheral ..
  84. ncbi Rotenone potentiates dopamine neuron loss in animals exposed to lipopolysaccharide prenatally
    Zaodung Ling
    Department of Pharmacology, Rush University Medical Center, Chicago, IL 60612, USA
    Exp Neurol 190:373-83. 2004
    ..treating female Sprague-Dawley rats exposed to LPS or saline prenatally with a subtoxic dose of the DA neurotoxin rotenone (1.25 mg/kg per day) or vehicle for 14 days when they were 16 months old...
  85. ncbi Partial mitochondrial inhibition causes striatal dopamine release suppression and medium spiny neuron depolarization via H2O2 elevation, not ATP depletion
    Li Bao
    Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 25:10029-40. 2005
    ..We show here that acute exposure to the mitochondrial complex I inhibitor rotenone (30-100 nM; 30 min) causes concentration-dependent suppression of single-pulse evoked dopamine (DA) release ..
  86. doi Mitochondrial complex I inhibitor rotenone inhibits and redistributes vesicular monoamine transporter 2 via nitration in human dopaminergic SH-SY5Y cells
    Masahiko Watabe
    Department of Pharmacology, Teikyo University School of Medicine, 2 11 1, Kaga, Itabashi ku, Tokyo 173 8605, Japan
    Mol Pharmacol 74:933-40. 2008
    ..Long-term systemic mitochondrial complex I inhibition by rotenone induces selective degeneration of dopaminergic neurons in rats...
  87. doi Neuroprotective efficacy of Bacopa monnieri against rotenone induced oxidative stress and neurotoxicity in Drosophila melanogaster
    Ravikumar Hosamani
    Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Council of Scientific and Industrial Research, Mysore 570020, India
    Neurotoxicology 30:977-85. 2009
    ..Environmental toxins like rotenone, a specific inhibitor of complex I is employed to increase oxidative stress mediated neuropathology and sporadic ..
  88. doi Mechanism of the neuroprotective role of coenzyme Q10 with or without L-dopa in rotenone-induced parkinsonism
    Amany A Abdin
    Department of Pharmacology, Faculty of Medicine, Tanta University, Al Geish Street, Tanta, Egypt
    Neuropharmacology 55:1340-6. 2008
    ..the light on the role of coenzyme Q10 with or without L-dopa in an experimental model of parkinsonism induced by rotenone in rats. The present work showed that rotenone (2.5 mg/kg/day i.p...
  89. doi Increased vulnerability to rotenone-induced neurotoxicity in ceruloplasmin-deficient mice
    Kazuma Kaneko
    Department of Neurology and Rheumatology, Shinshu University School of Medicine, 3 1 1 Asahi, 390 8621 Matsumoto, Japan
    Neurosci Lett 446:56-8. 2008
    ..b>Rotenone, a selective mitochondrial complex I inhibitor, induces neurodegeneration mimicking Parkinson's disease...
  90. ncbi Mouse model of optic neuropathy caused by mitochondrial complex I dysfunction
    Xian Zhang
    Institute for Neuroscience and Center for Molecular and Cellular Toxicology, University of Texas at Austin, Austin, TX 78712, USA
    Neurosci Lett 326:97-100. 2002
    ..a mouse model of optic neuropathy caused by mitochondrial complex I dysfunction by intravitreal administration of rotenone, a complex I inhibitor, in CBA/J mice...
  91. ncbi Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis
    Ho Young Lee
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 97:1695-9. 2005
    ..These results indicate that deguelin warrants consideration as a chemopreventive agent for early-stage lung carcinogenesis in a clinical lung cancer chemoprevention trial...
  92. pmc Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease
    T A Yacoubian
    Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cell Death Dis 1:e2. 2010
    ..overexpressing each 14-3-3 isoform, we found that overexpression of 14-3-3θ, ε, or γ led to resistance to both rotenone and 1-methyl-4-phenylpyridinium (MPP(+)), while other isoforms were not protective against both toxins...
  93. pmc Protection by the NDI1 gene against neurodegeneration in a rotenone rat model of Parkinson's disease
    Mathieu Marella
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 3:e1433. 2008
    ..In fact, rotenone, a complex I inhibitor, has been used for establishing PD models both in vitro and in vivo...
  94. ncbi Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system
    Ranjita Betarbet
    Center for Neurodegenerative Disease, Center for Neurodegenerative Diseases, Whitehead Biomedical Research Building, 615 Michael Street, Atlanta, GA 30322, USA
    Neurobiol Dis 22:404-20. 2006
    ..here, we used in vivo and in vitro models of chronic low-grade complex I inhibition with the pesticide rotenone. Chronic rotenone exposure in vivo caused oxidative modification of DJ-1, accumulation of alpha-synuclein, and ..
  95. ncbi The neurobehavioral changes induced by bilateral rotenone lesion in medial forebrain bundle of rats are reversed by L-DOPA
    M Alam
    Zoological Institute, Neuropharmacology, University of Tuebingen, Morgenstelle 28E, Tuebingen 72076, Germany
    Behav Brain Res 151:117-24. 2004
    b>Rotenone (an inhibitor of mitochondrial complex I) has been proposed as a model of Parkinson's disease (PD) as it induces nigrostriatal degeneration associated with alpha-synuclein inclusions...
  96. ncbi Metabolic stress in PC12 cells induces the formation of the endogenous dopaminergic neurotoxin, 3,4-dihydroxyphenylacetaldehyde
    I Lamensdorf
    CNS, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Neurosci Res 60:552-8. 2000
    ..The rapid appearance of DOPAL and DOPET after inhibition of complex I may be a useful early index of oxidative stress in DA-forming neurons...
  97. ncbi PACAP protects neuronal differentiated PC12 cells against the neurotoxicity induced by a mitochondrial complex I inhibitor, rotenone
    Gang Wang
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Second Medical University, Shanghai, China
    FEBS Lett 579:4005-11. 2005
    ..Here, we showed that PACAP27 protects against neurotoxicity induced by rotenone, a mitochondrial complex I inhibitor that has been implicated in the pathogenesis of Parkinson's disease (PD)...
  98. ncbi The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK-PD experiments
    Paulien G M Ravenstijn
    Leiden Amsterdam Center for Drug Research, Leiden University, Division of Pharmacology, Leiden, The Netherlands
    J Pharmacol Toxicol Methods 57:114-30. 2008
    ..transport mechanisms in the course of Parkinsons disease (PD) progression, experiments were performed to characterise Parkinsons disease markers following subcutaneous (SC) and intracerebral (IC) infusion of the toxin rotenone in the rat.
  99. ncbi Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation
    Sampath Ramachandiran
    Center for Neurodegenerative Disease, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Toxicol Sci 95:163-71. 2007
    Paraquat, N-methyl-4-phenyl-1,2,3,6 tetrahydropyridine, and rotenone have been shown to reproduce several features of Parkinson's disease in animal and cell culture models...
  100. doi Bax shuttling after rotenone treatment of neuronal primary cultures: effects on cell death phenotypes
    Martin B Gill
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1072, USA
    J Neurosci Res 87:2047-65. 2009
    ..the role of Bax intracellular shuttling ER cell death signaling and necrotic-like cell death, we used rotenone-treated P5 neuronal cortical cultures to increase ER Bax levels and subsequent cell death signaling...
  101. ncbi Rotenone potentiates NMDA currents in substantia nigra dopamine neurons
    Yan Na Wu
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Neurosci Lett 421:96-100. 2007
    b>Rotenone is a pesticide that produces a rodent model of Parkinson's disease...

Research Grants75

  1. FLOW AND METABOLIC TRACER KINETICS IN HEART
    Robert Marshall; Fiscal Year: 2002
    ..b>Rotenone and its analogues are neutral, lipophilic compounds that are potent inhibitors of Complex 1 of the mitochondrial ..
  2. Deep Brain Stimulation in Parkinson's Models
    Marjorie Anderson; Fiscal Year: 2006
    ..In the proposed studies, the ability of chronic administration of the insecticide rotenone, to produce an animal model of Parkinson's disease will first be tested in monkeys...
  3. GI Endotoxin as an Environmental Trigger in an alpha-Synuclein Transgenic Mouse
    Robert L Nussbaum; Fiscal Year: 2010
    ..We will expose these transgenic animals to gram-negative endotoxin and rotenone, two agents frequently considered as environmental toxins most strongly implicated in PD...
  4. Proteomic Studies in Parkinson's Disease
    Jing Zhang; Fiscal Year: 2007
    ..A few neurotoxicants, e.g. rotenone, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine, all capable of inhibiting mitochondria and ..
  5. NADH-UBIQUINONE REDUCTASE OF PARACOCCUS DENITRIFICANS
    Takao Yagi; Fiscal Year: 1993
    ..ii) Identification of the DCCD-binding and the rotenone-binding subunit(s) of the Paracoccus NADH dehydrogenase complex...
  6. PROTON & ELECTRON TRANSFER & ENERGY COUPLING
    Tomoko Ohnishi; Fiscal Year: 1992
    ..chemical properties of the H+-carriers, (ii) investigate new inhibitors which are different from conventional rotenone-type compounds, (iii) measure the spatial organization of the redox components in the membrane using continuous ..
  7. Oxidative modification of brain proteins in pesticide intoxication
    PIER MASTROBERARDINO; Fiscal Year: 2007
    ..designed to identify those proteins that get oxidized following the administration of two different pesticides, rotenone or paraquat, and to validate their potential use as biomarkers in antioxidant therapy...
  8. Mitochondrial Response to Oxidative Stress
    DANIEL BOGENHAGEN; Fiscal Year: 2006
    ..A number of cellular toxins, including rotenone, 1-methyl-4-phenylpyridine (MPP+) and paraquat act to impair mitochondrial electron transport, generating ROS...
  9. Interaction Between Genes and the Mitochondria in Parkin
    Benjamin Wolozin; Fiscal Year: 2007
    ..We will mainly use rotenone as the model toxin for complex I disruption...
  10. Interaction Between Genes and the Mitochondria in Parkin
    Benjamin L Wolozin; Fiscal Year: 2010
    ..We will mainly use rotenone as the model toxin for complex I disruption...
  11. Endoplasmic Reticulum Stress and Parkinson's Disease
    David Ron; Fiscal Year: 2004
    ..Recent experiments from our lab indicate that 6-hydroxydopamine and Rotenone, toxins implicated in experimental and environmental PD, cause an imbalance between the folding capacity of the ..
  12. Mitochondrial Oxidative Stress and Protection in Pesticide-induced Neurotoxicity
    Jiyang Cai; Fiscal Year: 2007
    ..In animal models, selective toxicities to the nigrostriatal dopaminergic neurons occur after systemic exposure to rotenone and paraquat. Oxidative stress is a common mediator of pesticide-induced neurotoxicity...
  13. Calpain inhibitors in models of Parkinson's disease
    Michel Baudry; Fiscal Year: 2007
    ..against MPTP-mediated neurotoxicity and behavioral impairments in vivo in C57BI/6 mice, and against rotenone-mediated neurotoxicity in rats...
  14. Metabolic Oxidative Stress in Human Cancer Cells
    Douglas Spitz; Fiscal Year: 2007
    ..Specific Aim 1 will determine using electron transport chain blockers (i.e., antimycin A, myxothiazol, and rotenone), if intact human cancer cells (or isolated mitochondria) demonstrate alterations in ROS production by ..
  15. Metabolic Oxidative Stress in Human Cancer Cells
    Douglas Spitz; Fiscal Year: 2007
    ..Specific Aim 1 will determine using electron transport chain blockers (i.e., antimycin A, myxothiazol, and rotenone), if intact human cancer cells (or isolated mitochondria) demonstrate alterations in ROS production by ..
  16. Dopamine, mutant synuclein, oxidative stress and inflammation
    Howard J Federoff; Fiscal Year: 2010
    ..Efforts to elucidate thls mechanism have been aided by the linkage between toxicant (e.g., MPTP, paraquat. rotenone) injury, oxidative stress, inherited defects in turnover of the presynaptic and Lewy Body constituent protein a-..
  17. GENETICS OF MPTP-INDUCED PARKINSONISM
    Richard Smeyne; Fiscal Year: 2009
    ..blockade or transfer of GSTpi on cell death following administration of MPTP in vitro and in vivo; 3) Develop the rotenone model of experimental Parkinsonism in mice and determine if GSTp2 is altered in response to rotenone; 4) ..
  18. HEAT AND RADIATION EFFECTS ON TUMOR MICROCIRCULATION
    Mark Dewhirst; Fiscal Year: 2000
    ..Thus, we will determine how reduction in 02 consumption (induced by hypothermia, hyperglycemia, rotenone or metronidazole) or increase in blood 02 content (using carbogen, 100% 02, or hyperbaric 02) alone or in ..
  19. GENETICS OF MPTP-INDUCED PARKINSONISM
    Richard Smeyne; Fiscal Year: 2007
    ..blockade or transfer of GSTpi on cell death following administration of MPTP in vitro and in vivo; 3) Develop the rotenone model of experimental Parkinsonism in mice and determine if GSTp2 is altered in response to rotenone; 4) ..
  20. Mitochondrial Metabiolites to Treat Parkinson's Disease
    Bruce Ames; Fiscal Year: 2005
    ..our hypothesis using behavioral, biochemical, and immunohistochemical techniques on two models of PD: the chronic rotenone-exposed SK-N-MC human neuroblastoma cell model and the chronic rotenone-treated rat model...