nikethamide

Summary

Summary: A CENTRAL NERVOUS SYSTEM STIMULANT. It was formerly used in the treatment of barbiturate overdose but is now considered to be of no value for such purposes and may be dangerous. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1229)

Top Publications

  1. ncbi [The application of a broard spectrum automatic rapid drug identification system in acute drug poisoning]
    Hanbin Wang
    The Second Department of Internal Medicine, The Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100039, China
    Zhonghua Nei Ke Za Zhi 41:408-10. 2002
  2. ncbi Spectrophotometric determination of nikethamide by charge--transfer complexation with chloranilic acid
    G B Okide
    Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences University of Nigeria, Nsukka, Nigeria
    Boll Chim Farm 141:299-303. 2002
  3. ncbi [Role of 5-HT(2A) receptor in increase in respiratory-related rhythmic discharge activity by nikethamide in neonatal rat transverse medullary slices]
    Zhi bin Qian
    Department of Physiology, Southern Medical University, Guangzhou 510515, China
    Sheng Li Xue Bao 60:216-20. 2008
  4. ncbi Simultaneous determination of nikethamide and lidocaine in human blood and cerebrospinal fluid by high performance liquid chromatography
    Lili Chen
    West China School of Preclinical Medicine and Forensic Medicine, Sichuan University, No 17, Section 3, Renmin Nan Road, Chengdu 610041, PR China
    J Pharm Biomed Anal 43:1757-62. 2007
  5. ncbi Effect of quercetin-3-O-Sambubioside isolated from Eucommia ulmoides male flowers on spontaneous activity and convulsion rate in mice
    Xin Li
    College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, China
    Planta Med 80:974-7. 2014
  6. ncbi Confirmation of amphetamine, methamphetamine, MDA and MDMA in urine samples using disk solid-phase extraction and gas chromatography-mass spectrometry after immunoassay screening
    Zengping Huang
    Forensic Sciences Institute, Fujian Provincial Department of Public Security, Fuzhou 350003, China
    J Chromatogr B Analyt Technol Biomed Life Sci 792:241-7. 2003
  7. ncbi Sensitive determination of prohibited drugs in dried blood spots (DBS) for doping controls by means of a benchtop quadrupole/Orbitrap mass spectrometer
    Andreas Thomas
    Institute of Biochemistry, Center for Preventive Doping Research, German Sport University Cologne, Cologne, Germany
    Anal Bioanal Chem 403:1279-89. 2012
  8. ncbi Determination of stimulants using gas chromatography/high-resolution time-of-flight mass spectrometry and a soft ionization source
    Viorica Lopez-Avila
    Agilent Technologies, Santa Clara, CA, 95051, USA
    Rapid Commun Mass Spectrom 26:2714-24. 2012
  9. ncbi Enhancement of excitant amino acid release from rat brain slices by the convulsant 3-mercaptopropionic acid
    J H Skerritt
    Department of Pharmacology, University of Sydney, Sydney, NSW 2006, Australia
    Brain Res 258:165-9. 1983
  10. ncbi Sedative, hypnotic and anticonvulsant activities of the ethanol fraction from Rhizoma Pinelliae Praeparatum
    Xiang yang Wu
    School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China
    J Ethnopharmacol 135:325-9. 2011

Scientific Experts

  • Viorica Lopez-Avila
  • Andreas Thomas
  • Hanbin Wang
  • M Hilp
  • Zhi bin Qian
  • Xin Li
  • Min Zhang
  • Xiang yang Wu
  • Zhong hai Wu
  • Lili Chen
  • K Elkharraz
  • Namjin Baek
  • Jaehwi Lee
  • Kinam Park
  • Zengping Huang
  • Tooru Ooya
  • Lipeng Yang
  • Dongqing Fei
  • Yuxian Zhang
  • Shaoyang Liu
  • G B Okide
  • Fang Li
  • Ting Zhao
  • Jiang Li Zhao
  • Liu qing Yang
  • Ying Qi
  • Qiang Fu
  • Linchuan Liao
  • Yu Chen
  • Lin Yang
  • Junhong Hou
  • Youyi Yan
  • Zhong Zuo
  • I V Zverinskii
  • R Gust
  • H Suzuki
  • C Guse
  • J M Oger
  • N Faisant
  • B Arica-Yegin
  • F Siepmann
  • J Siepmann
  • J P Benoit
  • A Goepferich
  • Shaoyu Zhang
  • U E Odoh
  • U Ajali
  • V E Karpovich
  • L F Legon'kova
  • N G Mel'nichenko
  • H Sunada
  • L I Nechiporenko
  • V S Nikitin
  • R H Huang
  • M I Bushma
  • X H Ren
  • C Q He
  • D Zhou
  • D J Ding
  • E Z Chen
  • L S Rosenthal
  • M D Schechter
  • J H Skerritt
  • H J Sattler
  • H Schmitz
  • G A Johnston
  • W Schunack
  • J W Bean
  • E Curran
  • D J Nelson

Detail Information

Publications22

  1. ncbi [The application of a broard spectrum automatic rapid drug identification system in acute drug poisoning]
    Hanbin Wang
    The Second Department of Internal Medicine, The Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100039, China
    Zhonghua Nei Ke Za Zhi 41:408-10. 2002
    ..To describe the usefulness of REMEDi HS in the diagnosis of acute drug poisoning patients...
  2. ncbi Spectrophotometric determination of nikethamide by charge--transfer complexation with chloranilic acid
    G B Okide
    Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences University of Nigeria, Nsukka, Nigeria
    Boll Chim Farm 141:299-303. 2002
    A Spectrophotometric method is described for assay of nikethamide which was based on charge transfer complexation between it and chloranilic acid. They form a complex with stoichiometric ratio of 1:1 and showed l-max at 535 nm...
  3. ncbi [Role of 5-HT(2A) receptor in increase in respiratory-related rhythmic discharge activity by nikethamide in neonatal rat transverse medullary slices]
    Zhi bin Qian
    Department of Physiology, Southern Medical University, Guangzhou 510515, China
    Sheng Li Xue Bao 60:216-20. 2008
    To investigate the effects of nikethamide on the generation and modulation of rhythmic respiration of neonatal rats and the role of 5-HT(2A) receptor in this course, experiments were performed on the transverse medullary slices of ..
  4. ncbi Simultaneous determination of nikethamide and lidocaine in human blood and cerebrospinal fluid by high performance liquid chromatography
    Lili Chen
    West China School of Preclinical Medicine and Forensic Medicine, Sichuan University, No 17, Section 3, Renmin Nan Road, Chengdu 610041, PR China
    J Pharm Biomed Anal 43:1757-62. 2007
    b>Nikethamide and lidocaine are often requested to be quantified simultaneously in forensic toxicological analysis...
  5. ncbi Effect of quercetin-3-O-Sambubioside isolated from Eucommia ulmoides male flowers on spontaneous activity and convulsion rate in mice
    Xin Li
    College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, China
    Planta Med 80:974-7. 2014
    ..and convulsion rate in mice were recorded, and quercetin-3-O-sambubioside shows eminent effects similar to nikethamide on increasing spontaneous activity and stimulating the nerve center to enhance excitement...
  6. ncbi Confirmation of amphetamine, methamphetamine, MDA and MDMA in urine samples using disk solid-phase extraction and gas chromatography-mass spectrometry after immunoassay screening
    Zengping Huang
    Forensic Sciences Institute, Fujian Provincial Department of Public Security, Fuzhou 350003, China
    J Chromatogr B Analyt Technol Biomed Life Sci 792:241-7. 2003
    ..Confirmation and quantitation was exercised by selected ion monitoring using nikethamide as chromatographic standard. Recoveries of the amphetamines were between 73.0 and 104...
  7. ncbi Sensitive determination of prohibited drugs in dried blood spots (DBS) for doping controls by means of a benchtop quadrupole/Orbitrap mass spectrometer
    Andreas Thomas
    Institute of Biochemistry, Center for Preventive Doping Research, German Sport University Cologne, Cologne, Germany
    Anal Bioanal Chem 403:1279-89. 2012
    ..THC), tetrahydrocannabinol-9-carboxylic acid (THC-COOH), methylhexaneamine, methylphenidate, cocaine, nikethamide, 3,4-methylenedioxyamphetamine, N-methyl-3,4-methylenedioxyamphetamine, strychnine, mesocarb, salbutamol, ..
  8. ncbi Determination of stimulants using gas chromatography/high-resolution time-of-flight mass spectrometry and a soft ionization source
    Viorica Lopez-Avila
    Agilent Technologies, Santa Clara, CA, 95051, USA
    Rapid Commun Mass Spectrom 26:2714-24. 2012
    ..It was postulated that the use of a plasma gas such as Xe, which emits photons at a lower energy than Kr or Ar, would lead to softer ionization of the test compounds, and thus to less fragmentation...
  9. ncbi Enhancement of excitant amino acid release from rat brain slices by the convulsant 3-mercaptopropionic acid
    J H Skerritt
    Department of Pharmacology, University of Sydney, Sydney, NSW 2006, Australia
    Brain Res 258:165-9. 1983
    ..Several other convulsants, including bemegride (200 microM), benzodiazepine Ro-5-3663 (100 M), nikethamide (500 microM), pentylenetetrazole (500 microM), and 4,6,6-trimethylcaprolactam (100 and 500 microM), and the ..
  10. ncbi Sedative, hypnotic and anticonvulsant activities of the ethanol fraction from Rhizoma Pinelliae Praeparatum
    Xiang yang Wu
    School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China
    J Ethnopharmacol 135:325-9. 2011
    ..The present study aimed to investigate the sedative, hypnotic and anticonvulsant activities of ethanol fraction from Rhizoma Pinelliae Praeparatum (EFRP) and to determine whether these effects were related to GABAergic mechanism...
  11. ncbi [GABA A receptor participates in respiratory enhancement induced by nikethamide in neonatal rats]
    Zhi bin Qian
    Department of Physiology, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 28:301-4. 2008
    To investigate the role of GABA A receptor in nikethamide-induced respiratory enhancement in the medullary slices of neonatal rats.
  12. ncbi Paclitaxel-loaded microparticles and implants for the treatment of brain cancer: preparation and physicochemical characterization
    K Elkharraz
    College of Pharmacy, Freie Universitaet Berlin, Kelchstr 31, 12169 Berlin, Germany
    Int J Pharm 314:127-36. 2006
    ....
  13. ncbi Aqueous N,N-diethylnicotinamide (DENA) solution as a medium for accelerated release study of paclitaxel
    Namjin Baek
    Department of Pharmaceutics and Biomedical Engineering, Purdue University School of Pharmacy, Room G22, 575 Stadium Mall Drive, West Lafayette, IN 47907 2051, USA
    J Biomater Sci Polym Ed 15:527-42. 2004
    ..Our study suggests that the aqueous DENA solution can be used for the accelerated release study of PTX from PLGA matrices...
  14. ncbi Effects of ethylene glycol-based graft, star-shaped, and dendritic polymers on solubilization and controlled release of paclitaxel
    Tooru Ooya
    School of Materials Science, Japan Advanced Institute of Science and Technology, Tatsunokuchi, Ishikawa 923 1292, Japan
    J Control Release 93:121-7. 2003
    ..The availability of the new graft, star and dendritic polymers having ethylene glycol units should permit development of novel delivery systems for other poorly water-soluble drugs...
  15. ncbi Potentiation of cathinone by caffeine and nikethamide
    M D Schechter
    Department of Pharmacology, Northeastern Ohio University, College of Medicine, Rootstown 44272
    Pharmacol Biochem Behav 33:299-301. 1989
    The drug discrimination paradigm was employed to evaluate the effect of coadministration of both caffeine and nikethamide upon the discrimination of a low dose of cathinone. In rats trained to discriminate between 0...
  16. ncbi Solvent dependency of rotational barriers in ethamivan and comparison to nikethamide
    L S Rosenthal
    Department of Chemistry, Sackler Sciences Center, Clark University, Worcester, MA 01610
    Biochem Pharmacol 38:581-8. 1989
    ..in two drugs known to cause widespread stimulation in the mammalian central nervous system: ethamivan and nikethamide. Total NMR bandshape analysis was performed for the exchanging alkyl carbon resonances of these compounds as a ..
  17. ncbi [Pharmacokinetics and pharmacodynamics of nikethamide after endotracheal administration in dogs]
    R H Huang
    Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, China
    Zhongguo Yao Li Xue Bao 15:271-4. 1994
    ..Through the rubber tube, 10 ml sterized nikethamide (Nik) solution was rapidly injected into the tract via 10 ml syringe and 5 forceful ventilations were performed ..
  18. ncbi [Effects of oxygen and nikethamide on central drive, ventilation and blood gases of patients with obstructive lung disease in acute exacerbation of respiratory failure]
    X H Ren
    Beijing People s Hospital
    Zhonghua Jie He He Hu Xi Za Zhi 16:331-4, 373. 1993
    ..was divided into three steps: room air breathing, 35% O2 inhalation for one hour, and then intravenous drip of nikethamide (1.875g) for two hours with 35% oxygen inhalation at the same time...
  19. ncbi Mechanistic studies on hydrotropic solubilization of nifedipine in nicotinamide solution
    H Suzuki
    Fuji Laboratory, Janssen Kyowa Co, Ltd, Shizuoka, Japan
    Chem Pharm Bull (Tokyo) 46:125-30. 1998
    ..The significant contributor to the hydrotropic solubilization of nifedipine with nicotinamide was therefore the ligand hydrophobicity rather than the aromaticity of the pyridine ring...
  20. ncbi [The action of Essentiale and its combination with cordiamine and vitamin E on the processes of xenobiotic biotransformation and lipid peroxidation and on liver structure in rats with cholestasis]
    I V Zverinskii
    Institute of Biochemistry, Belarus Academy of Sciences Regional Clinical Hospital, Grodno
    Eksp Klin Farmakol 61:33-6. 1998
    ..Combination of essentiale with cordiamin (nikethamide) and viatmin E (50 mg/kg for 35 days) considerably activated the mono-oxigenase, glucoro- and glutathione ..
  21. ncbi Replacement of cyanogen bromide solution PH. EUR. with 1,3-dibromo-5,5-dimethylhydantoin (DBH). Analytical methods of pharmacopoeias with DBH in respect to environmental and economical concern, Part 13
    M Hilp
    Institut für Pharmazeutische Chemie der Philipps Universitat, Marburg, Germany
    Pharmazie 57:250-1. 2002
    PH. EUR. 2002 identifies nicotinamid, nicotinic acid, and nikethamide according the reaction of König using cyanogen bromide solution prepared with bromine water and ammonium thiocyanate immediately before use...
  22. ncbi [Picolylamides of the nicethamide type. 6. Structure-activity relationships of analeptics of the nicethamide type]
    H J Sattler
    Pharm Acta Helv 50:298-303. 1975