Genomes and Genes
Summary: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
Publications275 found, 100 shown here
- Anti-inflammatory effects of nicotinic acid in human monocytes are mediated by GPR109A dependent mechanismsJanet E Digby
Department of Cardiovascular Medicine, John Radcliffe Hospital, and Sir William Dunn School of Pathology, University of Oxford, Oxford, OX3 9DU, UK
Arterioscler Thromb Vasc Biol 32:669-76. 2012..We hypothesize that NA has the potential to act directly on monocytes to alter mediators of inflammation that may contribute to its antiatherogenic effects in vivo...
- Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitorsM John Chapman
INSERM, UMR S939, Dyslipidemia, Inflammation and Atherosclerosis Research Unit, University Pierre and Marie Curie Paris 6, Pavillon Benjamin Delessert, Hopital de la Pitie, 83 Boulevard de l hopital, Paris Cedex 13, France
Eur Heart J 31:149-64. 2010..e. statins, fibrates, and niacin, and compares their mechanisms of action with those of pharmacological agents under development which directly ..
- Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cellsMartina Lukasova
Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
J Clin Invest 121:1163-73. 2011Nicotinic acid (niacin) is a drug used to reduce the progression of atherosclerosis...
- Niacin promotes cholesterol efflux through stimulation of the PPARgamma-LXRalpha-ABCA1 pathway in 3T3-L1 adipocytesZhi hong Wu
Department of Cardiology, Second Xiangya Hospital, Central South University, Hunan 410011, PR China
Pharmacology 84:282-7. 2009The mechanism by which niacin increases plasma levels of high-density lipoprotein cholesterol (HDL-C) is not clearly understood yet...
- GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colonMuthusamy Thangaraju
Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912, USA
Cancer Res 69:2826-32. 2009..These studies show that GPR109A mediates the tumor-suppressive effects of the bacterial fermentation product butyrate in colon...
- Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosisEric Bruckert
Department of Endocrinology, Pitie Salpetriere University Hospital, Pierre and Marie Curie University, 83 bd de l hopital, 75651, Paris, France
Atherosclerosis 210:353-61. 2010....
- The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): final results and the impact of medication adherence, dose, and treatment durationTodd C Villines
Cardiology Service, Walter Reed Army Medical Center, Washington, DC 20307, USA
J Am Coll Cardiol 55:2721-6. 2010..This report describes the final results of the ARBITER 6-HALTS (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis) trial...
- Niacin inhibits vascular inflammation via the induction of heme oxygenase-1Ben J Wu
Lipid Research Group, The Heart Research Institute, 7 Eliza St, Newtown, NSW, Australia, 2042
Circulation 125:150-8. 2012..b>Niacin is a pleiotropic drug that slows the progression of coronary artery disease and increases serum levels of the HO-1 ..
- Niacin mediates lipolysis in adipose tissue through its G-protein coupled receptor HM74AYouyan Zhang
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
Biochem Biophys Res Commun 334:729-32. 2005A G-protein coupled receptor to niacin (nicotinic acid) was identified recently but the physiological/pharmacological role of the receptor remains poorly defined...
- Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cellsShobha H Ganji
Atherosclerosis Research Center, Department of Veterans Affairs Healthcare System, Long Beach, CA 90822, United States
Atherosclerosis 202:68-75. 2009In pharmacological doses, nicotinic acid (niacin) reduces myocardial infarction, stroke and atherosclerosis. The beneficial effects of niacin on lipoproteins are thought to mediate these effects...
- Extended-release niacin or ezetimibe and carotid intima-media thicknessAllen J Taylor
Cardiology Service, Walter Reed Army Medical Center, Washington, DC, USA
N Engl J Med 361:2113-22. 2009....
- beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in miceRobert W Walters
Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
J Clin Invest 119:1312-21. 2009..Furthermore, G protein-biased ligands that activate GPR109A in a beta-arrestin-independent fashion may represent an improved therapeutic option for the treatment of dyslipidemia...
- Effect of niacin on LXRalpha and PPARgamma expression and HDL-induced cholesterol efflux in adipocytes of hypercholesterolemic rabbitsShui Ping Zhao
Department of Cardiology, The Second Xiangya Hospital of Central South University, Middle Ren Min Road No 86, Changsha, Hunan 410011, PR China
Int J Cardiol 124:172-8. 2008..The aim of this study was to evaluate the effect of niacin on LXRalpha and PPARgamma expression and HDL-induced cholesterol efflux in adipocytes from hypercholesterolemic ..
- Evidence that niacin inhibits acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipidsBen J Wu
Lipid Research Group, Heart Research Institute, 7 Eliza St, Newtown, New South Wales, Australia 2042
Arterioscler Thromb Vasc Biol 30:968-75. 2010To determine if niacin can confer cardiovascular benefit by inhibiting vascular inflammation and improving endothelial function independent of changes in plasma lipid and lipoprotein levels.
- Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectinJanet E Digby
Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
Atherosclerosis 209:89-95. 2010....
- Niacin bound chromium treatment induces myocardial Glut-4 translocation and caveolar interaction via Akt, AMPK and eNOS phosphorylation in streptozotocin induced diabetic rats after ischemia-reperfusion injurySuresh Varma Penumathsa
Molecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1110, USA
Biochim Biophys Acta 1792:39-48. 2009..We investigated the effect of niacin-bound chromium (NBC) during ischemia/reperfusion (IR) injury in streptozotocin induced diabetic rats...
- Molecular identification of high and low affinity receptors for nicotinic acidAlan Wise
Department of 7TMR Systems Research, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom
J Biol Chem 278:9869-74. 2003..The discovery of HM74A as a molecular target for nicotinic acid may facilitate the discovery of superior drug molecules to treat dyslipidemia...
- Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathwaysHelen J Knowles
Cancer Research UK Molecular Oncology Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
Biochem Pharmacol 71:646-56. 2006HM74 and HM74a have been identified as receptors for niacin. HM74a mediates the pharmacological anti-lipolytic effects of niacin in adipocytes by reducing intracellular cyclic AMP (cAMP) and inhibiting release of free fatty acids into the ..
- Beneficial effects of combined treatment with niacin and chromium on the liver of hyperlipemic ratsSema Bolkent
Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, 34300 Cerrahpaşa, Istanbul, Turkey
Biol Trace Elem Res 101:219-29. 2004Many studies have shown that niacin and Cr exert combined effects. Significant beneficial effects in serum lipid levels following Cr supplementation have been reported...
- Co-enzyme Q10, riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapyVummidi Giridhar Premkumar
Department of Medical Biochemistry, DR A L M Post Graduate, Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, Tamil Nadu, India
Br J Nutr 100:1179-82. 2008..cancer patients were randomized to receive a daily supplement of 100 mg co-enzyme Q10, 10 mg riboflavin and 50 mg niacin (CoRN), one dosage per d along with 10 mg tamoxifen twice per d...
- Effects of prescription niacin and omega-3 fatty acids on lipids and vascular function in metabolic syndrome: a randomized controlled trialGregory C Shearer
Sanford Research USD, University of South Dakota, Sioux Falls, SD, USA
J Lipid Res 53:2429-35. 2012The metabolic syndrome includes both dyslipidemia and impaired vascular function. Because extended-release niacin (ERN) and prescription omega-3 acid ethyl-esters (P-OM3) independently improve these characteristics, we tested their ..
- Effects of dietary di(2-ethylhexyl)phthalate, a putative endocrine disrupter, on enzyme activities involved in the metabolism of tryptophan to niacin in ratsTsutomu Fukuwatari
Laboratories of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, 2500 Hassaka cho, Hikone, Shiga, 522 8533, Japan
Biochim Biophys Acta 1672:67-75. 2004We have reported that the conversion ratio of tryptophan to niacin increased with increasing dietary concentration of di(2-ethylhexyl)phthalate (DEHP); the conversion ratio was about 2...
- Simultaneous determination of atorvastatin and niacin in human plasma by LC-MS/MS and its application to a human pharmacokinetic studyVasu Babu Ravi
Research Studies, Rayalaseema University, Kurnool 518 002, India
Biomed Chromatogr 26:1436-43. 2012..and selective LC-MS/MS method has been developed and validated for quantification of the atorvastatin (AT) and niacin (NA) in 250 μL human plasma...
- Niacin increases HDL biogenesis by enhancing DR4-dependent transcription of ABCA1 and lipidation of apolipoprotein A-I in HepG2 cellsLin Hua Zhang
Atherosclerosis Research Center, Veterans Affairs Healthcare System, Long Beach, CA, USA
J Lipid Res 53:941-50. 2012..b>Niacin is the most effective lipid-regulating agent clinically available to raise HDL...
- Endothelial-vasoprotective effects of high-density lipoprotein are impaired in patients with type 2 diabetes mellitus but are improved after extended-release niacin therapySajoscha A Sorrentino
Klinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
Circulation 121:110-22. 2010..Moreover, in diabetic patients, we examined the impact of extended-release (ER) niacin therapy on the endothelial effects of HDL.
- Niacin restriction upregulates NADPH oxidase and reactive oxygen species (ROS) in human keratinocytesClaudia A Benavente
Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
Free Radic Biol Med 44:527-37. 2008..Removal of niacin from the cell culture medium allowed control of intracellular NAD...
- Adipokines and treatment with niacinSabine Westphal
Institute of Clinical Chemistry, Magdeburg University Hospital, D 39120 Magdeburg, Germany
Metabolism 55:1283-5. 2006..Because adipose tissue is one site of action of the lipid-lowering drug niacin, we investigated whether niacin treatment would affect not only lipids but also adipokines...
- Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDLM C Cheung
Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, School of Medicine, University of Washington, Seattle 98103, USA
Arterioscler Thromb Vasc Biol 21:1320-6. 2001..low HDL cholesterol (HDL-C) is to maximally increase the HDL-C to LDL-C ratio by combining lifestyle changes with niacin (N) plus a statin...
- Niacin and statin combination therapy for atherosclerosis regression and prevention of cardiovascular disease events: reconciling the AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health OuErin D Michos
The Johns Hopkins University School of Medicine, Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland 21287, USA
J Am Coll Cardiol 59:2058-64. 2012..Syndrome With Low HDL/High Triglycerides: Impact on Global Health Outcomes) trial, which compared combined niacin/simvastatin with simvastatin alone, failed to demonstrate an incremental benefit of niacin among patients with ..
- Relationship between glycemic status and progression of carotid intima-media thickness during treatment with combined statin and extended-release niacin in ARBITER 2Allen J Taylor
Cardiology Service, Walter Reed Army Medical Center, 6900 Georgia Avenue, NW, Building 2, Room 4A34, Washington, DC 20307 5001, USA
Vasc Health Risk Manag 3:159-64. 2007We previously reported in a placebo-controlled study that extended-release niacin slowed the progression of carotid atherosclerosis when added to statin monotherapy...
- Langerhans cells release prostaglandin D2 in response to nicotinic acidDominique Maciejewski-Lenoir
Arena Pharmaceuticals Inc, San Diego, California 92121, USA
J Invest Dermatol 126:2637-46. 2006..These results suggest that nicotinic acid mediates its flushing side effect by interacting with GPR109A on skin Langerhans cells, resulting in release of PGD(2)...
- Review of extended-release niacin/laropiprant fixed combination in the treatment of mixed dyslipidemia and primary hypercholesterolemiaKlaus G Parhofer
Medical Department II Grosshadern, University of Munich, Germany
Vasc Health Risk Manag 5:901-8. 2009..b>Niacin (nicotinic acid) is an effective drug which increases the plasma concentration of high-density lipoprotein (HDL)-..
- Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery diseaseJasleen K Duggal
Chicago Medical School and Affiliated Hospitals, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA
J Cardiovasc Pharmacol Ther 15:158-66. 2010b>Niacin or nicotinic acid (vitamin B3) raises the levels of high-density lipoprotein cholesterol (HDL) by about 30% to 35%...
- Safety and toxicological evaluation of a novel niacin-bound chromium (III) complexMichael Shara
Creighton University Medical Center, Omaha, NE, USA
J Inorg Biochem 99:2161-83. 2005..It also helps in energy production and increasing lean body mass. Niacin-bound chromium (NBC) is a unique form of bioavailable chromium that promotes healthy lipid profile...
- Nicotinic acid induces secretion of prostaglandin D2 in human macrophages: an in vitro model of the niacin flushC Daniel Meyers
Long Beach Veterans Affairs Healthcare System, Long Beach, CA, United States
Atherosclerosis 192:253-8. 2007..shown to prevent cardiovascular disease, yet its widespread use is limited by the prostaglandin D2 (PGD2) mediated niacin flush...
- Efficacy and safety of extended-release niacin/laropiprant plus statin vs. doubling the dose of statin in patients with primary hypercholesterolaemia or mixed dyslipidaemiaS Shah
Merck Research Laboratories, Cardiovascular Disease, Merck, Sharp and Dohme Corp, Rahway, NJ 07065, USA
Int J Clin Pract 64:727-38. 2010Co-administration of niacin with statin offers the potential for additional lipid management and cardiovascular risk reduction...
- Effects of high-dose modified-release nicotinic acid on atherosclerosis and vascular function: a randomized, placebo-controlled, magnetic resonance imaging studyJustin M S Lee
Department of Cardiovascular Medicine, University of Oxford and Oxford Centre for Clinical Magnetic Resonance Research OCMR, Oxford, United Kingdom
J Am Coll Cardiol 54:1787-94. 2009..Our aim was to determine the effects of high-dose (2 g) nicotinic acid (NA) on progression of atherosclerosis and measures of vascular function...
- Effects of oral niacin on endothelial dysfunction in patients with coronary artery disease: results of the randomized, double-blind, placebo-controlled INEF studyAscan Warnholtz
Department of Medicine II, Johannes Gutenberg University Mainz, Mainz, Germany
Atherosclerosis 204:216-21. 2009..Recent studies suggest that HDL-C directly improves endothelial function. Nicotinic acid (niacin) effectively raises serum HDL-C...
- Extended-release niacin raises adiponectin and leptinSabine Westphal
Institute of Clinical Chemistry, Magdeburg University Hospital, Leipziger Str 44, D 39120 Magdeburg, Germany
Atherosclerosis 193:361-5. 2007The lipid-lowering drug niacin has attracted renewed interest because it raises HDL-cholesterol and because it has recently been found to slow down the progression of intima media thickness in patients with coronary heart disease...
- Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cellsShobha H Ganji
Atherosclerosis Research Center, Department of Veterans Affairs Healthcare System, Long Beach, CA, USA
J Lipid Res 45:1835-45. 2004b>Niacin is a widely used lipid-regulating agent in dyslipidemic patients. Previously, we have shown that niacin inhibits triacylglycerol synthesis...
- Combined statin and niacin therapy remodels the high-density lipoprotein proteomePattie S Green
Department of Medicine, University of Washington, Seattle, WA, USA
Circulation 118:1259-67. 2008..We hypothesized that an intervention that increases HDL levels-combined statin and niacin therapy-might reverse these changes.
- Niacin and fibrates in atherogenic dyslipidemia: pharmacotherapy to reduce cardiovascular riskM John Chapman
Dyslipidemia, Inflammation and Atherosclerosis Research Unit, UMR S939, National Institute for Health and Medical Research INSERM, Hopital de la Pitie Salpetriere, Paris, France
Pharmacol Ther 126:314-45. 2010..In this context, there is renewed interest in pharmacotherapeutic strategies involving niacin and fibrates in monotherapy and in association with statins...
- Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary diseaseB G Brown
Department of Medicine, University of Washington School of Medicine, Seattle 98195, USA
N Engl J Med 345:1583-92. 2001..We studied simvastatin-niacin and antioxidant-vitamin therapy, alone and together, for cardiovascular protection in patients with coronary ..
- Nicotinic acid: pharmacological effects and mechanisms of actionAndreas Gille
Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany
Annu Rev Pharmacol Toxicol 48:79-106. 2008....
- Niacin-induced "flush" involves release of prostaglandin D2 from mast cells and serotonin from platelets: evidence from human cells in vitro and an animal modelDean Papaliodis
Department of Pharmacology and Experimental Therapeutics, Molecular Immunopharmacology and Drug Discovery Laboratory, Tufts University School of Medicine, Tufts Medical Center, Boston, MA 02111, USA
J Pharmacol Exp Ther 327:665-72. 2008b>Niacin lowers serum cholesterol, low-density lipoprotein, and triglycerides, and it raises high-density lipoprotein. However, most patients experience cutaneous warmth and vasodilation (flush)...
- Chronic niacin overload may be involved in the increased prevalence of obesity in US childrenDa Li
Institute of Basic Medical Sciences, Medical College, Dalian University, Dalian 116622, Liaoning Province, China
World J Gastroenterol 16:2378-87. 2010To investigate nicotinamide's action on glucose metabolism, and the association between niacin consumption and obesity prevalence.
- Nicotinic acid and the prevention of coronary artery diseaseJanet E Digby
Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
Curr Opin Lipidol 20:321-6. 2009..at all levels of LDL cholesterol has, therefore, given renewed emphasis on the therapeutic potential of niacin. The purpose of this review is to evaluate advances in the elucidation of mechanisms by which nicotinic acid ..
- A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skinElaine L Jacobson
Department of Pharmacology and Toxicology, College of Pharmacy, Tucson, AZ 85724, USA
Exp Dermatol 16:490-9. 2007....
- Patients' experiences of niacin-induced flushing in clinical practice: a structured telephone interviewSachin Kamal-Bahl
Merck and Co, Inc, West Point, Pennsylvania, USA
Clin Ther 31:130-40. 2009b>Niacin is highly effective at raising high-density lipoprotein cholesterol but remains underused because of the adverse event of flushing.
- Niacin stimulates adiponectin secretion through the GPR109A receptorEric P Plaisance
Department of Anatomy, Auburn University, Auburn, AL 36849, USA
Am J Physiol Endocrinol Metab 296:E549-58. 2009b>Niacin (nicotinic acid) has recently been shown to increase serum adiponectin concentrations in men with the metabolic syndrome...
- Niacin lowers serum phosphate and increases HDL cholesterol in dialysis patientsDaniela Muller
Franz Volhard Clinic, Department of Nephrology and Hypertension, Medical Faculty of the Charite, HELIOS Klinikum Berlin, Berlin, Germany
Clin J Am Soc Nephrol 2:1249-54. 2007..Adverse effects complicate the use of drugs that are prescribed for phosphate control in dialysis patients. Alternative treatment options are needed...
- Hemodynamic effects of nicotinic acid infusion in normotensive and hypertensive subjectsCrystal A Gadegbeku
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
Am J Hypertens 16:67-71. 2003..The adjustment in vascular compliance may be an important factor in determining overall BP response to NA...
- Extended-release niacin decreases serum fetuin-A concentrations in individuals with metabolic syndromeShalini V Kaushik
Department of Nutrition and Food Science, Auburn University, Auburn, AL 36849, USA
Diabetes Metab Res Rev 25:427-34. 2009..The goal of this study was to determine the effect of niacin administration on serum total- and phosphorylated fetuin-A (phosphofetuin-A) concentrations in individuals with ..
- Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytesXiaoyu Li
Institute for Translational Medicine and Therapeutics and Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
Biochem Pharmacol 80:1450-7. 2010The niacin receptor GPR109A is a G(i)-protein-coupled receptor which mediates the effects of niacin on inhibiting intracellular triglyceride lipolysis in adipocytes...
- Optical coherence tomography findings in niacin maculopathyHatem Marwan Dajani
The School of Medicine, Oregon Health and Science University, and the Devers Eye Institute, Legacy Hospitals, Portland, OR 97239 4197, USA
Can J Ophthalmol 41:197-200. 2006We present the case of 54-year-old male who developed bilateral cystoid macular thickening while taking 3 g of niacin per day, and we describe the optical coherence tomography (OCT) features of niacin (nicotinic acid) maculopathy.
- Increased total and high-molecular weight adiponectin after extended-release niacinEric P Plaisance
Department of Anatomy, Physiology and Pharmacology, Boshell Diabetes and Metabolic Diseases Research Program, Auburn University, Auburn, AL 36849, USA
Metabolism 57:404-9. 2008b>Niacin has recently been shown to increase serum total concentrations of the adipocyte-derived protein adiponectin...
- Induction of differentiation in human promyelocytic leukemia HL-60 cell line by niacin-related compoundsKeiko Iwata
Laboratory of Molecular and Cellular Biology, Department of Life Science, Faculty of Bioresources, Mie University, Tsu, Mie 514 8507, Japan
Biosci Biotechnol Biochem 67:1132-5. 2003Water-soluble vitamin, niacin, and its related compounds were examined for their differentiation-inducing activity in human promyelocytic leukemia cells (HL-60)...
- Opposite effects of nicotinic acid and pyridoxine on systemic prostacyclin, thromboxane and leukotriene production in manVirpi Saareks
Department of Pharmacological Sciences, University of Tampere, Finland
Pharmacol Toxicol 90:338-42. 2002....
- Niacin subsensitivity is associated with functional impairment in schizophreniaErik Messamore
Behavioral Health and Clinical Neurosciences Division, Portland VA Medical Center, Portland, OR 97239, USA
Schizophr Res 137:180-4. 2012Sensitivity to the skin flush effect of niacin is reduced in a portion of patients with schizophrenia...
- Safety, tolerance, and efficacy of extended-release niacin monotherapy for treating dyslipidemia risks in persons with chronic tetraplegia: a randomized multicenter controlled trialMark S Nash
Department of Neurological Surgery, University of Miami, Miller School of Medicine, Miami, FL, USA
Arch Phys Med Rehabil 92:399-410. 2011To test the safety, tolerance, and efficacy of extended-release niacin monotherapy on dyslipidemia in persons with chronic tetraplegia.
- Niacin promotes adipogenesis by reducing production of anti-adipogenic PGF2α through suppression of C/EBPβ-activated COX-2 expressionKo Fujimori
Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
Prostaglandins Other Lipid Mediat 94:96-103. 2011b>Niacin is converted to NAD and NADP in tissues, whose products are involved in a number of cellular processes; and it is associated with the regulation of adipogenesis...
- Dietary niacin and the risk of incident Alzheimer's disease and of cognitive declineM C Morris
Rush Institute for Healthy Aging, Centers for Disease Control and Prevention, Atlanta, GA, USA
J Neurol Neurosurg Psychiatry 75:1093-9. 2004Dementia can be caused by severe niacin insufficiency, but it is unknown whether variation in intake of niacin in the usual diet is linked to neurodegenerative decline...
- Nicotinic acid (niacin): new lipid-independent mechanisms of action and therapeutic potentialsMartina Lukasova
Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231 Bad Nauheim, Germany
Trends Pharmacol Sci 32:700-7. 2011Nicotinic acid (niacin) has been used for decades to prevent and treat atherosclerosis...
- Niacin and fibrate use among patients with high triglycerides and low high-density lipoprotein cholesterolPeter P Toth
Sterling Rock Falls Clinic, Sterling, IL 61081, USA
Curr Med Res Opin 25:1355-63. 2009..b>Niacin and fibrates have been shown in clinical trials to be effective as adjunctive therapy for these lipid abnormalities...
- Combination regimens with statin, niacin, and intestinally active LDL-lowering drugs: alternatives to high-dose statin therapy?John R Guyton
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Curr Opin Lipidol 21:372-7. 2010To summarize recent studies on combination regimens that employ a statin with added niacin, ezetimibe, and/or bile acid sequestrants, and to understand the implications of these studies for clinical practice.
- Water maze performance in young male Long-Evans rats is inversely affected by dietary intakes of niacin and may be linked to levels of the NAD+ metabolite cADPRGenevieve S Young
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
J Nutr 137:1050-7. 2007b>Niacin is converted in tissues to NAD(+), which is required for synthesis of the intracellular calcium signaling molecule cyclic ADP-ribose (cADPR)...
- Niacin toxicity resulting from urine drug test evasionAnne M Daul
Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina 28203, USA
J Emerg Med 41:e65-8. 2011b>Niacin, a well-established agent for treating dyslipidemia, has been promoted on the Internet as a method for passing urine drug screening, although there are no data to support its use for this purpose...
- Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppressionBrett Lauring
Merck Sharp and Dohme Corp, Whitehouse Station, NJ 07065, USA
Sci Transl Med 4:148ra115. 2012Nicotinic acid (niacin) induces beneficial changes in serum lipoproteins and has been associated with beneficial cardiovascular effects...
- Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER) 2: a double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statinsAllen J Taylor
Cardiovascular Research, Cardiology Service, Walter Reed Army Medical Center, 6900 Georgia Ave, NW, Bldg 2, Room 3L28, Washington, DC 20307 5001, USA
Circulation 110:3512-7. 2004b>Niacin reduces coronary heart disease morbidity and mortality when taken either alone or in combination with statins; however, the incremental impact of adding niacin to background statin therapy is unknown.
- Role of prostaglandin D2 and the autonomic nervous system in niacin-induced flushingHenri K Parson
Division of Endocrinology and Metabolism, Department of Medicine, Strelitz Diabetes Center for Endocrine and Metabolic Disorders, Eastern Virginia Medical School, Norfolk, VA, USA
J Diabetes 5:59-67. 2013Although niacin often has beneficial effects on the lipoprotein profile, flushing is an untoward effect associated with its use. Aspirin can only reduce the flushing response by 30-40%...
- Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapibLaurent Yvan-Charvet
Division of Molecular Medicine, Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032, USA
Arterioscler Thromb Vasc Biol 30:1430-8. 2010To examine the effects of treatments with niacin or anacetrapib (an inhibitor of cholesteryl ester transfer protein) on the ability of high-density lipoprotein (HDL) to promote net cholesterol efflux and reduce toll-like receptor-mediated ..
- Niacin treatment of the atherogenic lipid profile and Lp(a) in diabetesJ Pan
Diabetes Research Center, Tustin, CA, USA
Diabetes Obes Metab 4:255-61. 2002We tested the hypotheses that niacin is effective for the separate treatments of abnormalities of LDL particle size, HDL2 percentage and Lp(a) without potential negative effects on glycated haemoglobin.
- Blood pressure-lowering effects of extended-release niacin alone and extended-release niacin/laropiprant combination: a post hoc analysis of a 24-week, placebo-controlled trial in dyslipidemic patientsHarold E Bays
Louisville Metabolic and Atherosclerosis Research Center Inc, Louisville, Kentucky, USA
Clin Ther 31:115-22. 2009Dyslipidemia and high blood pressure are both major cardiovascular disease risk factors. Niacin is an effective lipid-altering agent that has been reported to reduce the risk of cardiovascular disease...
- Niacin status and treatment-related leukemogenesisJames B Kirkland
University of Guelph, Guelph, Ontario, Canada, N1G 2W1
Mol Cancer Ther 8:725-32. 2009..b>Niacin deficiency, which is common in cancer patients, causes dramatic genomic instability in bone marrow cells in an in ..
- Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failureKyu hyang Cho
Division of Nephrology and Hypertension, University of California, Irvine, California, USA
Am J Physiol Renal Physiol 297:F106-13. 2009..b>Niacin is known to improve lipid metabolism and exert antioxidant/anti-inflammatory actions...
- Protective effects of a novel niacin-bound chromium complex and a grape seed proanthocyanidin extract on advancing age and various aspects of syndrome XHarry G Preuss
Department of Physiology, Georgetown University Medical Center, Washington, D C 20007, USA
Ann N Y Acad Sci 957:250-9. 2002..Accordingly, ingestion of niacin-bound chromium and natural antioxidants such as grape seed proanthocyanidin extract has been demonstrated to ..
- High-affinity transporters for NAD+ precursors in Candida glabrata are regulated by Hst1 and induced in response to niacin limitationBiao Ma
Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
Mol Cell Biol 29:4067-79. 2009..C. glabrata is a NAD(+) auxotroph, and its growth depends on the availability of niacin (environmental vitamin precursors of NAD(+))...
- Decreasing the oxidant stress from paraquat in isolated perfused rat lung using captopril and niacinMahmoud Ghazi-Khansari
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P O Box 13145 784, Tehran, Iran
Arch Toxicol 79:341-5. 2005The abilities of captopril and niacin to protect against the lung toxicity of paraquat (PQ) were studied...
- Flushing profile of extended-release niacin/laropiprant versus gradually titrated niacin extended-release in patients with dyslipidemia with and without ischemic cardiovascular diseaseDarbie Maccubbin
Merck Research Laboratories, Rahway, NJ, USA
Am J Cardiol 104:74-81. 2009b>Niacin has beneficial effects on a patient's lipid and lipoprotein profiles and cardiovascular risk, particularly at doses >2 g/day, but is underused due to flushing...
- Comparison of rat and dog models of vasodilatation and lipolysis for the calculation of a therapeutic index for GPR109A agonistsEster Carballo-Jane
Department of Pharmacology, Merck Research Laboratories, Rahway, NJ, USA
J Pharmacol Toxicol Methods 56:308-16. 2007..The rat and the dog have previously been used to study the antilipolytic effects of nicotinic acid, but no optimal vasodilatation model exits in either species...
- SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacinM Carola Zillikens
Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
Free Radic Biol Med 46:836-41. 2009SIRT1 protects cells against oxidative stress and aging. Its activity may be modulated by dietary niacin (vitamin B3) intake...
- Biochemical assessment of niacin deficiency among carcinoid cancer patientsGirish M Shah
Laboratory for Skin Cancer Research, CHUL Research Center CHUQ, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada
Am J Gastroenterol 100:2307-14. 2005..fraction of tryptophan catabolism, which should be directed along a pathway that allows partial conversion to niacin; hence, increased diversion of tryptophan toward serotonin could cause variable degrees of niacin deficiency in ..
- Does nicotinic acid (niacin) lower blood pressure?H E Bays
Louisville Metabolic and Atherosclerosis Research Center, Louisville, KY40213, USA
Int J Clin Pract 63:151-9. 2009Nicotinic acid (niacin) is a well-established treatment for dyslipidaemia - an important cardiovascular disease (CVD) risk factor. However, niacin may also reduce blood pressure (BP), which is another important CVD risk factor...
- Treatment with niacin lowers ADMASabine Westphal
Atherosclerosis 184:448-50. 2006
- Niacin and carcinogenesisJames B Kirkland
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
Nutr Cancer 46:110-8. 2003The dietary status of niacin (vitamin B3) has the potential to influence DNA repair, genomic stability, and the immune system, eventually having an impact on cancer risk, as well as the side effects of chemotherapy in the cancer patient...
- Combined effects of niacin and chromium treatment on vascular endothelial dysfunction in hyperlipidemic ratsN Niu
Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China
Mol Biol Rep 36:1275-81. 2009Combined treatment with niacin and chromium has been found to have a protective effect against oxidative damage to different tissues of hyperlipidemic rats. But its effects on vascular endothelial dysfunction are less clear...
- Postprandial triglyceride responses to aerobic exercise and extended-release niacinEric P Plaisance
Department of Kinesiology, Auburn University, Auburn, AL, USA
Am J Clin Nutr 88:30-7. 2008Aerobic exercise and niacin are frequently used strategies for reducing serum triglycerides, and, yet, there is no information regarding the combined effects of these strategies on postprandial triglycerides.
- Niacin: a powerful adjunct to other lipid-lowering drugs in reducing plaque progression and acute coronary eventsMichael H Davidson
Department of Preventive Cardiology, Rush Presbyterian St Luke s Medical Center, 1725 West Harrison Street, Chicago, IL 60612, USA
Curr Atheroscler Rep 5:418-22. 2003
- Clinical inquiries. Should liver enzymes be checked in a patient taking niacin?Gloria S Rizakallah
St Louis College of Pharmacy and Mercy Family Medicine, St Louis, MO USA
J Fam Pract 54:265-8. 2005
- Niacin nutritional status in HIV type 1-positive children: preliminary dataMarina Hjertquist Tremeschin
Medical School of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
J Pediatr Gastroenterol Nutr 44:629-33. 2007..This study compared the nutritional status and the 24-hour urine excretion of N-methylnicotinamide between HIV-positive children and HIV-negative children who were or were not born of mothers with HIV-1 infection...
- Laropiprant plus niacin for dyslipidemia and prevention of cardiovascular diseaseAnders G Olsson
Department of Medicine and Health, Linkoping University, SE 58183 Linkoping, Sweden
Expert Opin Pharmacother 11:1715-26. 2010..The best drug available for that purpose is niacin. In addition to increasing HDL cholesterol and apolipoprotein A1, niacin decreases triglycerides, low-density ..
- Niacin treatment of stroke increases synaptic plasticity and axon growth in ratsXu Cui
Department of Neurology, Henry Ford Hospital, Detroit, Mich 48202, USA
Stroke 41:2044-9. 2010b>Niacin is the most effective medication in current clinical use for increasing high-density lipoprotein cholesterol...
- Hypophosphatemic effect of niacin in patients without renal failure: a randomized trialDarbie Maccubbin
Rhode Island Hospital, Division of Kidney Diseases and Hypertension, 593 Eddy Street, Providence, RI, 02903, USA
Clin J Am Soc Nephrol 5:582-9. 2010b>Niacin administration lowers the marked hyperphosphatemia that is characteristic of renal failure...
- Niacin's role in the statin eraErica L Brooks
Preventive Cardiology Center, Tufts Medical Center, Division of Cardiology, Department of Medicine, 800 Washington Street, Box 80, Boston, MA 02111, USA
Expert Opin Pharmacother 11:2291-300. 2010The combination use of niacin and HMG Co-A reductases (statins) is increasing. While statin therapy reduces the risk of adverse cardiovascular events, additional therapies are needed to decrease event rates further...
- Niacin therapy in atherosclerosisC Daniel Meyers
Endocrinology Section, VA Long Beach Healthcare System, Department of Medicine, University of California, Irvine, California, USA
Curr Opin Lipidol 15:659-65. 2004Well designed, randomized, placebo-controlled studies show that niacin prevents cardiovascular disease and death...
- The effects of niacin on lipoprotein subclass distributionJohn M Morgan
Thomas Jefferson University, Jefferson Heart Institute, Sidney Kimmel Laboratory for Preventive Medicine, 925 Chestnut Street, 1st Floor, Philadelphia, PA 19107, USA
Prev Cardiol 7:182-7; quiz 188. 2004..b>Niacin has long been known to improve concentrations of all major lipids and lipoproteins, but it also has consistently ..
- Niacin and laropiprantS Sanyal
Division of Cardiology, Department of Medicine, Preventive Cardiology Center, Tufts Medical Center, Boston, MA 02111, USA
Drugs Today (Barc) 46:371-8. 2010Nicotinic acid (niacin) is one of the oldest drugs used to treat dyslipidemia...
- Effects of extended release niacin/laropiprant, laropiprant, extended release niacin and placebo on platelet aggregation and bleeding time in healthy subjectsEseng Lai
Merck Research Laboratories, Rahway, NJ 07065, USA
Platelets 21:191-8. 2010Laropiprant (LRPT) has been shown to reduce flushing symptoms induced by niacin and has been combined with niacin for treatment of dyslipidemia...
- Seeing red: flushing out instigators of niacin-associated skin toxicityRichard L Dunbar
Department of Medicine, Division of Experimental Therapeutics, Institute for Translational Medicine and Therapeutics, Pennsylvania 19104, USA
J Clin Invest 120:2651-5. 2010The use of niacin to improve plasma lipid levels and reduce risk of myocardial infarction is limited by noxious skin effects that result from stimulation of G protein-coupled receptor 109A (GPR109A) in skin immune cells...
- Beneficial effects of rosuvastatin alone and in combination with extended-release niacin in patients with a combined hyperlipidemia and low high-density lipoprotein cholesterol levelsDavid M Capuzzi
Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Am J Cardiol 91:1304-10. 2003..and low high-density lipoprotein (HDL) cholesterol levels may benefit from combination therapy with a statin and niacin; therefore, we assessed the efficacy and safety of rosuvastatin and extended-release (ER) niacin alone and in ..
- Effect of Extended-Release Niacin on Saphenous Vein Graft AtherosclerosisEmmanouil Brilakis; Fiscal Year: 2010..b>Niacin raises HDL-C, restores the re-endothelialization capacity of EPCs, and slowed the progression of SVG ..
- Aromatic amino acid metabolism in the pathogenesis of kwashiorkorFarook Jahoor; Fiscal Year: 2007..are precursors for dopamine, melanin and the catecholamines, and tryptophan is the precursor of serotonin and niacin, a shortage of the AAAs may underlie most of the signs and symptoms of kwashiorkor...
- LIPOGENESIS & LIPOPROTEIN COMPLICATIONS OF HIV THERAPYDavid Hui; Fiscal Year: 2004..The potential beneficial effects of niacin, due to its proteasome-independent stimulation of apoB degradation, will also be explored...
- Discovery and Preclinical Development of Drugs for Anthrax, Plague and TularemiaChristie Brouillette; Fiscal Year: 2007..These diseases are caused by three of the highest risk bacterial bioterrorism agents, B. anthracis, Y. pestis, and F. tularensis. ..
- Comprehensive Magnetic Resonance in PADChristopher M Kramer; Fiscal Year: 2010..Aim 3 is to use comprehensive MR to test the efficacy of raising HDL with a novel formulation of niacin with laropiprant that reduces flushing compared to placebo in mild to moderate PAD...
- OMEGA-3 FATTY ACIDS IN BIPOLAR DISORDER PROPHYLAXISANDREW STOLL; Fiscal Year: 2002..Plasma and erythrocyte fatty acid content. 2. The niacin skin patch test (a possible marker of in vivo omega-3 fatty acid activity). 3...
- MECHANISMS OF ENZYMATIC REACTIONSPERRY FREY; Fiscal Year: 2002..in studies of Ga1E will be to describe the molecular basis for the enhancement of the chemical reactivity of the niacin- co-enzyme NAD+ by the use of binding energy between the UDP-moiety of substrates and the enzyme...
- HDL AND PLAQUES--NOVEL MODELS AND IMAGING TECHNIQUESEdward Fisher; Fiscal Year: 2001..Plasma lipid levels will be modified by therapy with a statin or statin plus niacin (to raise HDL) and changes in plaque size and composition will be followed serially by MRI...
- Niacin, n-3 fatty acids and insulin resistanceWilliam Harris; Fiscal Year: 2006..In recent studies from our laboratory, niacin and fish oil (n-3 fatty acids, FA) used in combination in individuals with the IRS improved the lipid phenotype, ..
- Niacin, n-3 fatty acids and insulin resistanceWilliam Harris; Fiscal Year: 2007..In recent studies from our laboratory, niacin and fish oil (n-3 fatty acids, FA) used in combination in individuals with the IRS improved the lipid phenotype, ..
- MODE OF ACTION OF PYRAZINAMIDE IN TUBERCLE BACILLUSYing Zhang; Fiscal Year: 1999..Because of structural similarity of POA to niacin, they hypothesize that POA may interfere with NAD metabolism in M...
- MODE OF ACTION OF PYRAZINAMIDE IN TUBERCLE BACILLUSYing Zhang; Fiscal Year: 2003..Because of structural similarity of POA to niacin, they hypothesize that POA may interfere with NAD metabolism in M...
- A Transdermal Hypolipidemic Niacin ProdrugHyuntae Kim; Fiscal Year: 2002b>Niacin has been used as first-line drug therapy for elevated serum cholesterol because of its broad efficacy on multiple lipid components as well as its low cost...
- Diet/Exercise, Niacin, Fenofibrate for HIV LipodystrophyAshok Balasubramanyam; Fiscal Year: 2007..fat mass and improve hormonal, metabolic and lipoprotein markers associated with insulin resistance; and 2) adding niacin, fenofibrate, or a combination of the two drugs to the intensive lifestyle intervention will result in further ..
- Diet/Exercise, Niacin, Fenofibrate for HIV LipodystrophyAshok Balasubramanyam; Fiscal Year: 2007..fat mass and improve hormonal, metabolic and lipoprotein markers associated with insulin resistance; and 2) adding niacin, fenofibrate, or a combination of the two drugs to the intensive lifestyle intervention will result in further ..
- A Trial of Zinc and Micronutrients in Tanzanian ChildrenChristopher P Duggan; Fiscal Year: 2010..be recruited and randomly assigned in a factorial design to either zinc, micronutrients (vitamins C, E, B1, B2, niacin, B6, folate, and B12) plus zinc, micronutrients without zinc, or a placebo given daily...
- A Trial of Zinc and Micronutrients in Tanzanian ChildrenChristopher Duggan; Fiscal Year: 2007..be recruited and randomly assigned in a factorial design to either zinc, micronutrients (vitamins C, E, B1, B2, niacin, B6, folate, and B12) plus zinc, micronutrients without zinc, or a placebo given daily...
- Monitoring Oxygen Repeatedly for Hypoxic Tumor TherapyMohammad Khan; Fiscal Year: 2007..The proposed approach to modulate tumor hypoxia will avoid possible complications and toxicity arising due to oral or injections of drugs. If successful, this approach potentially could be immediately extended for clinical applications. ..
- MECHANISMS OF ENZYMATIC REACTIONSPERRY FREY; Fiscal Year: 2006..of epimerase will be to elucidate the molecular basis for the enhancement of the chemical reactivity of the niacin-coenzyme NAD+ by the use of binding energy between substrates and the enzyme...