Genomes and Genes
Summary: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
Publications307 found, 100 shown here
- Niacin mediates lipolysis in adipose tissue through its G-protein coupled receptor HM74AYouyan Zhang
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
Biochem Biophys Res Commun 334:729-32. 2005A G-protein coupled receptor to niacin (nicotinic acid) was identified recently but the physiological/pharmacological role of the receptor remains poorly defined...
- Anti-inflammatory effects of nicotinic acid in human monocytes are mediated by GPR109A dependent mechanismsJanet E Digby
Department of Cardiovascular Medicine, John Radcliffe Hospital, and Sir William Dunn School of Pathology, University of Oxford, Oxford, OX3 9DU, UK
Arterioscler Thromb Vasc Biol 32:669-76. 2012..We hypothesize that NA has the potential to act directly on monocytes to alter mediators of inflammation that may contribute to its antiatherogenic effects in vivo...
- Niacin promotes cholesterol efflux through stimulation of the PPARgamma-LXRalpha-ABCA1 pathway in 3T3-L1 adipocytesZhi hong Wu
Department of Cardiology, Second Xiangya Hospital, Central South University, Hunan 410011, PR China
Pharmacology 84:282-7. 2009The mechanism by which niacin increases plasma levels of high-density lipoprotein cholesterol (HDL-C) is not clearly understood yet...
- Supplementing obese Zucker rats with niacin induces the transition of glycolytic to oxidative skeletal muscle fibersRobert Ringseis
Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig University, Giessen, Germany
J Nutr 143:125-31. 2013In the present study, we tested the hypothesis that niacin increases the oxidative capacity of muscle by increasing the oxidative type I muscle fiber content...
- Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitorsM John Chapman
INSERM, UMR S939, Dyslipidemia, Inflammation and Atherosclerosis Research Unit, University Pierre and Marie Curie Paris 6, Pavillon Benjamin Delessert, Hopital de la Pitie, 83 Boulevard de l hopital, Paris Cedex 13, France
Eur Heart J 31:149-64. 2010..e. statins, fibrates, and niacin, and compares their mechanisms of action with those of pharmacological agents under development which directly ..
- Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cellsShobha H Ganji
Atherosclerosis Research Center, Department of Veterans Affairs Healthcare System, Long Beach, CA 90822, United States
Atherosclerosis 202:68-75. 2009In pharmacological doses, nicotinic acid (niacin) reduces myocardial infarction, stroke and atherosclerosis. The beneficial effects of niacin on lipoproteins are thought to mediate these effects...
- Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectinJanet E Digby
Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
Atherosclerosis 209:89-95. 2010....
- Effects of prescription niacin and omega-3 fatty acids on lipids and vascular function in metabolic syndrome: a randomized controlled trialGregory C Shearer
Sanford Research USD, University of South Dakota, Sioux Falls, SD, USA
J Lipid Res 53:2429-35. 2012The metabolic syndrome includes both dyslipidemia and impaired vascular function. Because extended-release niacin (ERN) and prescription omega-3 acid ethyl-esters (P-OM3) independently improve these characteristics, we tested their ..
- PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effectSorin Tunaru
Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany
Nat Med 9:352-5. 2003Nicotinic acid (niacin), a vitamin of the B complex, has been used for almost 50 years as a lipid-lowering drug. The pharmacological effect of nicotinic acid requires doses that are much higher than those provided by a normal diet...
- Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cellsMartina Lukasova
Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
J Clin Invest 121:1163-73. 2011Nicotinic acid (niacin) is a drug used to reduce the progression of atherosclerosis...
- Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosisEric Bruckert
Department of Endocrinology, Pitie Salpetriere University Hospital, Pierre and Marie Curie University, 83 bd de l hopital, 75651, Paris, France
Atherosclerosis 210:353-61. 2010....
- The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): final results and the impact of medication adherence, dose, and treatment durationTodd C Villines
Cardiology Service, Walter Reed Army Medical Center, Washington, DC 20307, USA
J Am Coll Cardiol 55:2721-6. 2010..This report describes the final results of the ARBITER 6-HALTS (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis) trial...
- Niaspan increases angiogenesis and improves functional recovery after strokeJieli Chen
Department of Neurology, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA
Ann Neurol 62:49-58. 2007High-density lipoprotein (HDL) is implicated in the modulation of angiogenesis. In this study, we investigated whether the Niacin-mediated increase of HDL regulates angiogenesis and thereby improves functional outcome after stroke.
- Why do some yeast species require niacin for growth? Different modes of NAD synthesisYou Fang Li
CNRS UMR 8621, Institut de Genetique et Microbiologie, Universite Paris Sud 11, Orsay, France
FEMS Yeast Res 7:657-64. 2007..lactis. The results suggested that the basis of the variation of niacin requirements in yeasts lies in their different combinations of NAD biosynthesis pathways...
- GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colonMuthusamy Thangaraju
Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912, USA
Cancer Res 69:2826-32. 2009..These studies show that GPR109A mediates the tumor-suppressive effects of the bacterial fermentation product butyrate in colon...
- GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathyDeeksha Gambhir
Department of Biochemistry and Molecular Biology, and the Vision Science Discovery Institute, Georgia Health Sciences University, Augusta, Georgia 30912, USA
Invest Ophthalmol Vis Sci 53:2208-17. 2012Retinal pigment epithelium (RPE) expresses GPR109A, a receptor for the vitamin niacin and the ketone body β-hydroxybutyrate (β-HB)...
- Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary diseaseB G Brown
Department of Medicine, University of Washington School of Medicine, Seattle 98195, USA
N Engl J Med 345:1583-92. 2001..We studied simvastatin-niacin and antioxidant-vitamin therapy, alone and together, for cardiovascular protection in patients with coronary ..
- Widespread effects of nicotinic acid on gene expression in insulin-sensitive tissues: implications for unwanted effects of nicotinic acid treatmentSangdun Choi
Department of Molecular Science and Technology, Ajou University, Suwon, South Korea
Metabolism 60:134-44. 2011Nicotinic acid (NA; or niacin) has been used as a hypolipidemic agent for more than 4 decades. However, the mechanisms underlying the effects of NA treatment (wanted and unwanted) are still poorly understood...
- Niacin status, NAD distribution and ADP-ribose metabolismJames B Kirkland
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
Curr Pharm Des 15:3-11. 2009Dietary niacin deficiency, and pharmacological excesses of nicotinic acid or nicotinamide, have dramatic effects on cellular NAD pools, ADP-ribose metabolism, tissue function and health...
- Niacin: the evidence, clinical use, and future directionsTodd C Villines
Cardiology Service, Department of Medicine, Walter Reed National Military Medical Center, 8901 Rockville Pike, Bethesda, MD 20889, USA
Curr Atheroscler Rep 14:49-59. 2012The use of FDA-approved niacin (nicotinic acid or vitamin B3) formulations at therapeutic doses, alone or in combination with statins or other lipid therapies, is safe, improves multiple lipid parameters, and reduces atherosclerosis ..
- Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathwaysHelen J Knowles
Cancer Research UK Molecular Oncology Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
Biochem Pharmacol 71:646-56. 2006HM74 and HM74a have been identified as receptors for niacin. HM74a mediates the pharmacological anti-lipolytic effects of niacin in adipocytes by reducing intracellular cyclic AMP (cAMP) and inhibiting release of free fatty acids into the ..
- Niacin and statin combination therapy for atherosclerosis regression and prevention of cardiovascular disease events: reconciling the AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health OuErin D Michos
The Johns Hopkins University School of Medicine, Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland 21287, USA
J Am Coll Cardiol 59:2058-64. 2012..Syndrome With Low HDL/High Triglycerides: Impact on Global Health Outcomes) trial, which compared combined niacin/simvastatin with simvastatin alone, failed to demonstrate an incremental benefit of niacin among patients with ..
- Extended-release niacin or ezetimibe and carotid intima-media thicknessAllen J Taylor
Cardiology Service, Walter Reed Army Medical Center, Washington, DC, USA
N Engl J Med 361:2113-22. 2009....
- Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapibLaurent Yvan-Charvet
Division of Molecular Medicine, Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032, USA
Arterioscler Thromb Vasc Biol 30:1430-8. 2010To examine the effects of treatments with niacin or anacetrapib (an inhibitor of cholesteryl ester transfer protein) on the ability of high-density lipoprotein (HDL) to promote net cholesterol efflux and reduce toll-like receptor-mediated ..
- Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in miceJulien Hanson
Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
J Clin Invest 120:2910-9. 2010..These data will help to guide new efficient approaches to mitigate nicotinic acid-induced flushing and may help to exploit the potential antipsoriatic effects of GPR109A agonists in the skin...
- Evidence that niacin inhibits acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipidsBen J Wu
Lipid Research Group, Heart Research Institute, 7 Eliza St, Newtown, New South Wales, Australia 2042
Arterioscler Thromb Vasc Biol 30:968-75. 2010To determine if niacin can confer cardiovascular benefit by inhibiting vascular inflammation and improving endothelial function independent of changes in plasma lipid and lipoprotein levels.
- Niacin bound chromium treatment induces myocardial Glut-4 translocation and caveolar interaction via Akt, AMPK and eNOS phosphorylation in streptozotocin induced diabetic rats after ischemia-reperfusion injurySuresh Varma Penumathsa
Molecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1110, USA
Biochim Biophys Acta 1792:39-48. 2009..We investigated the effect of niacin-bound chromium (NBC) during ischemia/reperfusion (IR) injury in streptozotocin induced diabetic rats...
- Effect of niacin on LXRalpha and PPARgamma expression and HDL-induced cholesterol efflux in adipocytes of hypercholesterolemic rabbitsShui Ping Zhao
Department of Cardiology, The Second Xiangya Hospital of Central South University, Middle Ren Min Road No 86, Changsha, Hunan 410011, PR China
Int J Cardiol 124:172-8. 2008..The aim of this study was to evaluate the effect of niacin on LXRalpha and PPARgamma expression and HDL-induced cholesterol efflux in adipocytes from hypercholesterolemic ..
- beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in miceRobert W Walters
Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
J Clin Invest 119:1312-21. 2009..Furthermore, G protein-biased ligands that activate GPR109A in a beta-arrestin-independent fashion may represent an improved therapeutic option for the treatment of dyslipidemia...
- Molecular identification of high and low affinity receptors for nicotinic acidAlan Wise
Department of 7TMR Systems Research, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom
J Biol Chem 278:9869-74. 2003..The discovery of HM74A as a molecular target for nicotinic acid may facilitate the discovery of superior drug molecules to treat dyslipidemia...
- Effects of oral niacin on endothelial dysfunction in patients with coronary artery disease: results of the randomized, double-blind, placebo-controlled INEF studyAscan Warnholtz
Department of Medicine II, Johannes Gutenberg University Mainz, Mainz, Germany
Atherosclerosis 204:216-21. 2009..Recent studies suggest that HDL-C directly improves endothelial function. Nicotinic acid (niacin) effectively raises serum HDL-C...
- Niacin treatment of stroke increases synaptic plasticity and axon growth in ratsXu Cui
Department of Neurology, Henry Ford Hospital, Detroit, Mich 48202, USA
Stroke 41:2044-9. 2010b>Niacin is the most effective medication in current clinical use for increasing high-density lipoprotein cholesterol...
- Change in alpha1 HDL concentration predicts progression in coronary artery stenosisBela F Asztalos
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center on Aging at Tufts University and Division of Endocrinology, Metabolism, Diabetes, and Molecular Medicine, New England Medical Center, Boston, Mass 02111, USA
Arterioscler Thromb Vasc Biol 23:847-52. 2003We examined the effects of simvastatin-niacin and antioxidant vitamins on changes in high-density lipoprotein (HDL) subpopulations and alterations in coronary artery stenosis, as assessed by angiography.
- Niacin in cardiovascular prevention: mechanisms, efficacy, and safetyJohn R Guyton
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Curr Opin Lipidol 18:415-20. 2007This review describes niacin's mechanism of action, efficacy in cardiovascular prevention, and safety.
- Comparative genomics of NAD biosynthesis in cyanobacteriaSvetlana Y Gerdes
Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
J Bacteriol 188:3012-23. 2006..generated nicotinamide, as supported by the inability of this organism to utilize exogenously provided niacin. Positional clustering and the co-occurrence profile of the respective genes across a diverse collection of ..
- Extended-release niacin raises adiponectin and leptinSabine Westphal
Institute of Clinical Chemistry, Magdeburg University Hospital, Leipziger Str 44, D 39120 Magdeburg, Germany
Atherosclerosis 193:361-5. 2007The lipid-lowering drug niacin has attracted renewed interest because it raises HDL-cholesterol and because it has recently been found to slow down the progression of intima media thickness in patients with coronary heart disease...
- Niacin and cholesterol: role in cardiovascular disease (review)Shobha H Ganji
Atherosclerosis Research Center, Department of Veterans Affairs Healthcare System, Long Beach, California, USA
J Nutr Biochem 14:298-305. 2003b>Niacin has been widely used as a pharmacologic agent to regulate abnormalities in plasma lipid and lipoprotein metabolism and in the treatment of atherosclerotic cardiovascular disease...
- Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesisNagendra Singh
Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA Cancer Research Center, Georgia Regents University, Augusta, GA 30912, USA Electronic address
Immunity 40:128-39. 2014..GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation...
- The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regressionPaul M Lavigne
Molecular Cardiology Research Institute, Division of Cardiology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts 02111, USA
J Am Coll Cardiol 61:440-6. 2013This study sought to assess the efficacy of niacin for reducing cardiovascular disease (CVD) events, as indicated by the aggregate body of clinical trial evidence including data from the recently published AIM-HIGH (Atherothrombosis ..
- Intravenous niacin acutely improves the efficiency of dietary fat storage in lean and obese humansRobert H Nelson
Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota, USA
Diabetes 61:3172-5. 2012..overweight and obese (n = 5) subjects during continuous feeding on two occasions: during intravenous infusion of niacin (2.8 mg/min) and saline...
- Niacin reduces plasma CETP levels by diminishing liver macrophage content in CETP transgenic miceZhaosha Li
Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
Biochem Pharmacol 84:821-9. 2012The anti-dyslipidemic drug niacin has recently been shown to reduce the hepatic expression and plasma levels of CETP...
- Niacin extended-release/simvastatin combination therapy produces larger favorable changes in high-density lipoprotein particles than atorvastatin monotherapyPeter P Toth
Department of Family and Community Medicine, University of Illinois College of Medicine, Peoria, CGH Medical Center, 101 East Miller Road, Sterling, IL 61081, USA
Vasc Health Risk Manag 8:39-44. 2012The purpose of this research was to compare the effects of niacin extended-release in combination with simvastatin (NER/S) versus atorvastatin monotherapy on high-density lipoprotein (HDL) particle number and size in patients with ..
- Niaspan increases axonal remodeling after stroke in type 1 diabetes ratsTao Yan
Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China
Neurobiol Dis 46:157-64. 2012..We investigated axonal plasticity in the bilateral motor cortices and the long term therapeutic effect of Niaspan on axonal remodeling after stroke in type-1 diabetic (T1DM) rats...
- Niacin inhibits vascular inflammation via the induction of heme oxygenase-1Ben J Wu
Lipid Research Group, The Heart Research Institute, 7 Eliza St, Newtown, NSW, Australia, 2042
Circulation 125:150-8. 2012..b>Niacin is a pleiotropic drug that slows the progression of coronary artery disease and increases serum levels of the HO-1 ..
- Nicotinic acid (niacin): new lipid-independent mechanisms of action and therapeutic potentialsMartina Lukasova
Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231 Bad Nauheim, Germany
Trends Pharmacol Sci 32:700-7. 2011Nicotinic acid (niacin) has been used for decades to prevent and treat atherosclerosis...
- Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed miceDesiree Wanders
Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA
PLoS ONE 8:e71285. 2013To determine the effects of niacin on adiponectin and markers of adipose tissue inflammation in a mouse model of obesity.
- Increased total and high-molecular weight adiponectin after extended-release niacinEric P Plaisance
Department of Anatomy, Physiology and Pharmacology, Boshell Diabetes and Metabolic Diseases Research Program, Auburn University, Auburn, AL 36849, USA
Metabolism 57:404-9. 2008b>Niacin has recently been shown to increase serum total concentrations of the adipocyte-derived protein adiponectin...
- The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndromeM Thoenes
Institut fur Klinische Pharmakologie, Technische Universitat Dresden, Dresden, Germany
Int J Clin Pract 61:1942-8. 2007b>Niacin is an agent that significantly increases high-density lipoprotein cholesterol (HDL-C), but its effects on surrogate markers of atherosclerosis and inflammatory markers are less clear...
- Recent advances in niacin and lipid metabolismVaijinath S Kamanna
Atherosclerosis Research Center, Department of Veterans Affairs Healthcare System, Long Beach, California 90822, USA
Curr Opin Lipidol 24:239-45. 2013This review focuses on the current understanding of the physiological mechanisms of action of niacin on lipid metabolism and atherosclerosis.
- Co-enzyme Q10, riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapyVummidi Giridhar Premkumar
Department of Medical Biochemistry, DR A L M Post Graduate, Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, Tamil Nadu, India
Br J Nutr 100:1179-82. 2008..cancer patients were randomized to receive a daily supplement of 100 mg co-enzyme Q10, 10 mg riboflavin and 50 mg niacin (CoRN), one dosage per d along with 10 mg tamoxifen twice per d...
- Niacin increases HDL biogenesis by enhancing DR4-dependent transcription of ABCA1 and lipidation of apolipoprotein A-I in HepG2 cellsLin Hua Zhang
Atherosclerosis Research Center, Veterans Affairs Healthcare System, Long Beach, CA, USA
J Lipid Res 53:941-50. 2012..b>Niacin is the most effective lipid-regulating agent clinically available to raise HDL...
- Adipokines and treatment with niacinSabine Westphal
Institute of Clinical Chemistry, Magdeburg University Hospital, D 39120 Magdeburg, Germany
Metabolism 55:1283-5. 2006..Because adipose tissue is one site of action of the lipid-lowering drug niacin, we investigated whether niacin treatment would affect not only lipids but also adipokines...
- Effects of dietary di(2-ethylhexyl)phthalate, a putative endocrine disrupter, on enzyme activities involved in the metabolism of tryptophan to niacin in ratsTsutomu Fukuwatari
Laboratories of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, 2500 Hassaka cho, Hikone, Shiga, 522 8533, Japan
Biochim Biophys Acta 1672:67-75. 2004We have reported that the conversion ratio of tryptophan to niacin increased with increasing dietary concentration of di(2-ethylhexyl)phthalate (DEHP); the conversion ratio was about 2...
- Endothelial-vasoprotective effects of high-density lipoprotein are impaired in patients with type 2 diabetes mellitus but are improved after extended-release niacin therapySajoscha A Sorrentino
Klinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
Circulation 121:110-22. 2010..Moreover, in diabetic patients, we examined the impact of extended-release (ER) niacin therapy on the endothelial effects of HDL.
- Simultaneous determination of atorvastatin and niacin in human plasma by LC-MS/MS and its application to a human pharmacokinetic studyVasu Babu Ravi
Research Studies, Rayalaseema University, Kurnool 518 002, India
Biomed Chromatogr 26:1436-43. 2012..and selective LC-MS/MS method has been developed and validated for quantification of the atorvastatin (AT) and niacin (NA) in 250 μL human plasma...
- Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDLM C Cheung
Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, School of Medicine, University of Washington, Seattle 98103, USA
Arterioscler Thromb Vasc Biol 21:1320-6. 2001..low HDL cholesterol (HDL-C) is to maximally increase the HDL-C to LDL-C ratio by combining lifestyle changes with niacin (N) plus a statin...
- Safety and toxicological evaluation of a novel niacin-bound chromium (III) complexMichael Shara
Creighton University Medical Center, Omaha, NE, USA
J Inorg Biochem 99:2161-83. 2005..It also helps in energy production and increasing lean body mass. Niacin-bound chromium (NBC) is a unique form of bioavailable chromium that promotes healthy lipid profile...
- Relationship between glycemic status and progression of carotid intima-media thickness during treatment with combined statin and extended-release niacin in ARBITER 2Allen J Taylor
Cardiology Service, Walter Reed Army Medical Center, 6900 Georgia Avenue, NW, Building 2, Room 4A34, Washington, DC 20307 5001, USA
Vasc Health Risk Manag 3:159-64. 2007We previously reported in a placebo-controlled study that extended-release niacin slowed the progression of carotid atherosclerosis when added to statin monotherapy...
- Langerhans cells release prostaglandin D2 in response to nicotinic acidDominique Maciejewski-Lenoir
Arena Pharmaceuticals Inc, San Diego, California 92121, USA
J Invest Dermatol 126:2637-46. 2006..These results suggest that nicotinic acid mediates its flushing side effect by interacting with GPR109A on skin Langerhans cells, resulting in release of PGD(2)...
- Nicotinic acid induces secretion of prostaglandin D2 in human macrophages: an in vitro model of the niacin flushC Daniel Meyers
Long Beach Veterans Affairs Healthcare System, Long Beach, CA, United States
Atherosclerosis 192:253-8. 2007..shown to prevent cardiovascular disease, yet its widespread use is limited by the prostaglandin D2 (PGD2) mediated niacin flush...
- Review of extended-release niacin/laropiprant fixed combination in the treatment of mixed dyslipidemia and primary hypercholesterolemiaKlaus G Parhofer
Medical Department II Grosshadern, University of Munich, Germany
Vasc Health Risk Manag 5:901-8. 2009..b>Niacin (nicotinic acid) is an effective drug which increases the plasma concentration of high-density lipoprotein (HDL)-..
- Efficacy and safety of extended-release niacin/laropiprant plus statin vs. doubling the dose of statin in patients with primary hypercholesterolaemia or mixed dyslipidaemiaS Shah
Merck Research Laboratories, Cardiovascular Disease, Merck, Sharp and Dohme Corp, Rahway, NJ 07065, USA
Int J Clin Pract 64:727-38. 2010Co-administration of niacin with statin offers the potential for additional lipid management and cardiovascular risk reduction...
- Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery diseaseJasleen K Duggal
Chicago Medical School and Affiliated Hospitals, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA
J Cardiovasc Pharmacol Ther 15:158-66. 2010b>Niacin or nicotinic acid (vitamin B3) raises the levels of high-density lipoprotein cholesterol (HDL) by about 30% to 35%...
- Niacin therapy in atherosclerosisC Daniel Meyers
Endocrinology Section, VA Long Beach Healthcare System, Department of Medicine, University of California, Irvine, California, USA
Curr Opin Lipidol 15:659-65. 2004Well designed, randomized, placebo-controlled studies show that niacin prevents cardiovascular disease and death...
- Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiaeCristina Panozzo
Centre de Genetique Moleculaire, Laboratoire propre du CNRS, associé à l Université Pierre et Marie Curie, Gif sur Yvette, France
FEBS Lett 517:97-102. 2002..cerevisiae. Also, we show that under anaerobic conditions S. cerevisiae is a nicotinic acid auxotroph...
- High-affinity transporters for NAD+ precursors in Candida glabrata are regulated by Hst1 and induced in response to niacin limitationBiao Ma
Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
Mol Cell Biol 29:4067-79. 2009..C. glabrata is a NAD(+) auxotroph, and its growth depends on the availability of niacin (environmental vitamin precursors of NAD(+))...
- The nicotinic acid receptor--a new mechanism for an old drugFredrik Karpe
Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK
Lancet 363:1892-4. 2004..Suppression of lipolysis by nicotinic acid gives rise to a prominent rebound and the degree to which this occurs might explain this paradox...
- Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failureKyu hyang Cho
Division of Nephrology and Hypertension, University of California, Irvine, California, USA
Am J Physiol Renal Physiol 297:F106-13. 2009..b>Niacin is known to improve lipid metabolism and exert antioxidant/anti-inflammatory actions...
- Effects of high-dose modified-release nicotinic acid on atherosclerosis and vascular function: a randomized, placebo-controlled, magnetic resonance imaging studyJustin M S Lee
Department of Cardiovascular Medicine, University of Oxford and Oxford Centre for Clinical Magnetic Resonance Research OCMR, Oxford, United Kingdom
J Am Coll Cardiol 54:1787-94. 2009..Our aim was to determine the effects of high-dose (2 g) nicotinic acid (NA) on progression of atherosclerosis and measures of vascular function...
- Niacin and fibrates in atherogenic dyslipidemia: pharmacotherapy to reduce cardiovascular riskM John Chapman
Dyslipidemia, Inflammation and Atherosclerosis Research Unit, UMR S939, National Institute for Health and Medical Research INSERM, Hopital de la Pitie Salpetriere, Paris, France
Pharmacol Ther 126:314-45. 2010..In this context, there is renewed interest in pharmacotherapeutic strategies involving niacin and fibrates in monotherapy and in association with statins...
- Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cellsShobha H Ganji
Atherosclerosis Research Center, Department of Veterans Affairs Healthcare System, Long Beach, CA, USA
J Lipid Res 45:1835-45. 2004b>Niacin is a widely used lipid-regulating agent in dyslipidemic patients. Previously, we have shown that niacin inhibits triacylglycerol synthesis...
- Combined statin and niacin therapy remodels the high-density lipoprotein proteomePattie S Green
Department of Medicine, University of Washington, Seattle, WA, USA
Circulation 118:1259-67. 2008..We hypothesized that an intervention that increases HDL levels-combined statin and niacin therapy-might reverse these changes.
- Nicotinic acid: pharmacological effects and mechanisms of actionAndreas Gille
Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany
Annu Rev Pharmacol Toxicol 48:79-106. 2008....
- Niacin restriction upregulates NADPH oxidase and reactive oxygen species (ROS) in human keratinocytesClaudia A Benavente
Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
Free Radic Biol Med 44:527-37. 2008..Removal of niacin from the cell culture medium allowed control of intracellular NAD...
- Patients' experiences of niacin-induced flushing in clinical practice: a structured telephone interviewSachin Kamal-Bahl
Merck and Co, Inc, West Point, Pennsylvania, USA
Clin Ther 31:130-40. 2009b>Niacin is highly effective at raising high-density lipoprotein cholesterol but remains underused because of the adverse event of flushing.
- Niacin-induced "flush" involves release of prostaglandin D2 from mast cells and serotonin from platelets: evidence from human cells in vitro and an animal modelDean Papaliodis
Department of Pharmacology and Experimental Therapeutics, Molecular Immunopharmacology and Drug Discovery Laboratory, Tufts University School of Medicine, Tufts Medical Center, Boston, MA 02111, USA
J Pharmacol Exp Ther 327:665-72. 2008b>Niacin lowers serum cholesterol, low-density lipoprotein, and triglycerides, and it raises high-density lipoprotein. However, most patients experience cutaneous warmth and vasodilation (flush)...
- A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skinElaine L Jacobson
Department of Pharmacology and Toxicology, College of Pharmacy, Tucson, AZ 85724, USA
Exp Dermatol 16:490-9. 2007....
- Nicotinic acid and the prevention of coronary artery diseaseJanet E Digby
Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
Curr Opin Lipidol 20:321-6. 2009..at all levels of LDL cholesterol has, therefore, given renewed emphasis on the therapeutic potential of niacin. The purpose of this review is to evaluate advances in the elucidation of mechanisms by which nicotinic acid ..
- Chronic niacin overload may be involved in the increased prevalence of obesity in US childrenDa Li
Institute of Basic Medical Sciences, Medical College, Dalian University, Dalian 116622, Liaoning Province, China
World J Gastroenterol 16:2378-87. 2010To investigate nicotinamide's action on glucose metabolism, and the association between niacin consumption and obesity prevalence.
- Niacin stimulates adiponectin secretion through the GPR109A receptorEric P Plaisance
Department of Anatomy, Auburn University, Auburn, AL 36849, USA
Am J Physiol Endocrinol Metab 296:E549-58. 2009b>Niacin (nicotinic acid) has recently been shown to increase serum adiponectin concentrations in men with the metabolic syndrome...
- Hemodynamic effects of nicotinic acid infusion in normotensive and hypertensive subjectsCrystal A Gadegbeku
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
Am J Hypertens 16:67-71. 2003..The adjustment in vascular compliance may be an important factor in determining overall BP response to NA...
- Niacin lowers serum phosphate and increases HDL cholesterol in dialysis patientsDaniela Muller
Franz Volhard Clinic, Department of Nephrology and Hypertension, Medical Faculty of the Charite, HELIOS Klinikum Berlin, Berlin, Germany
Clin J Am Soc Nephrol 2:1249-54. 2007..Adverse effects complicate the use of drugs that are prescribed for phosphate control in dialysis patients. Alternative treatment options are needed...
- Effects of niacin on glucose levels, coronary stenosis progression, and clinical events in subjects with normal baseline glucose levels (<100 mg/dl): a combined analysis of the Familial Atherosclerosis Treatment Study (FATS), HDL-Atherosclerosis TreatmBinh An P Phan
Division of Cardiology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA
Am J Cardiol 111:352-5. 2013Although the effect of niacin on the glucose levels in subjects with diabetes mellitus has been investigated, niacin's effects on the glucose levels and atherosclerosis in subjects with normal glucose levels have not been well established...
- Beneficial effects of combined treatment with niacin and chromium on the liver of hyperlipemic ratsSema Bolkent
Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, 34300 Cerrahpaşa, Istanbul, Turkey
Biol Trace Elem Res 101:219-29. 2004Many studies have shown that niacin and Cr exert combined effects. Significant beneficial effects in serum lipid levels following Cr supplementation have been reported...
- Management of complex lipid abnormalities with a fixed dose combination of simvastatin and extended release niacinJennifer G Robinson
University of Iowa, Iowa City, IA, USA
Vasc Health Risk Manag 5:31-43. 2009ER niacin combined with simvastatin provides an additional option for achieving LDL-C and non-HDL-C goals for cardiovascular prevention, with greater efficacy in those with triglyceride levels >200 mg/dL...
- Niacin: chemical forms, bioavailability, and health effectsDouglas MacKay
Council for Responsible Nutrition, Washington, DC 20036, USA
Nutr Rev 70:357-66. 2012..b>Niacin is considered a valuable agent for therapy to modify high LDL-C as well as low HDL-C, high lipoprotein a, and ..
- The benefits of niacin in atherosclerosisS Tavintharan
Cholesterol Research Center, Department of Veterans Affairs Healthcare System, University of California, Irvine, 5901 East Seventh Street (11/111-I) Long Beach, CA 90822, USA
Curr Atheroscler Rep 3:74-82. 2001b>Niacin favorably alters all major lipid subfractions at pharmacologic doses. Alone or in combination, it promotes regression of coronary artery disease, decreases coronary events, stroke, and total mortality...
- Effects of encapsulated niacin on metabolism and production of periparturient dairy cowsS D Morey
Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506, USA
J Dairy Sci 94:5090-104. 2011Nicotinic acid (niacin) can suppress lipolysis, but responses to dietary niacin have been inconsistent in cattle. Our aim was to determine if 24 g/d of encapsulated niacin (EN; providing 9...
- Niacin attenuates lung inflammation and improves survival during sepsis by downregulating the nuclear factor-κB pathwayWoon Yong Kwon
Department of Emergency Medicine, Seoul National University College of Medicine, Seoul, Korea
Crit Care Med 39:328-34. 2011To examine whether niacin attenuates lung inflammation and improves survival during sepsis and to determine whether the beneficial effects of niacin are associated with downregulation of the nuclear factor (NF)-κB pathway.
- Quercetin with vitamin C and niacin does not affect body mass or compositionAmy M Knab
North Carolina Research Campus, Human Performance Laboratory, Kannapolis, NC 28081, USA
Appl Physiol Nutr Metab 36:331-8. 2011..This study investigated 12-week supplementation of 2 different doses of quercetin, combined with vitamin C and niacin, on body mass and composition in a large, heterogeneous group of adults (n = 941; 60% female, 40% male; 18-85 ..
- Niacin status impacts chromatin structureJames B Kirkland
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
J Nutr 139:2397-401. 2009b>Niacin is required to form NAD and NADP, which are involved in many essential redox reactions in cellular metabolism...
- Optical coherence tomography findings in niacin maculopathyHatem Marwan Dajani
The School of Medicine, Oregon Health and Science University, and the Devers Eye Institute, Legacy Hospitals, Portland, OR 97239 4197, USA
Can J Ophthalmol 41:197-200. 2006We present the case of 54-year-old male who developed bilateral cystoid macular thickening while taking 3 g of niacin per day, and we describe the optical coherence tomography (OCT) features of niacin (nicotinic acid) maculopathy.
- Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytesXiaoyu Li
Institute for Translational Medicine and Therapeutics and Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
Biochem Pharmacol 80:1450-7. 2010The niacin receptor GPR109A is a G(i)-protein-coupled receptor which mediates the effects of niacin on inhibiting intracellular triglyceride lipolysis in adipocytes...
- Extended-release niacin decreases serum fetuin-A concentrations in individuals with metabolic syndromeShalini V Kaushik
Department of Nutrition and Food Science, Auburn University, Auburn, AL 36849, USA
Diabetes Metab Res Rev 25:427-34. 2009..The goal of this study was to determine the effect of niacin administration on serum total- and phosphorylated fetuin-A (phosphofetuin-A) concentrations in individuals with ..
- Opposite effects of nicotinic acid and pyridoxine on systemic prostacyclin, thromboxane and leukotriene production in manVirpi Saareks
Department of Pharmacological Sciences, University of Tampere, Finland
Pharmacol Toxicol 90:338-42. 2002....
- Safety, tolerance, and efficacy of extended-release niacin monotherapy for treating dyslipidemia risks in persons with chronic tetraplegia: a randomized multicenter controlled trialMark S Nash
Department of Neurological Surgery, University of Miami, Miller School of Medicine, Miami, FL, USA
Arch Phys Med Rehabil 92:399-410. 2011To test the safety, tolerance, and efficacy of extended-release niacin monotherapy on dyslipidemia in persons with chronic tetraplegia.
- Niacin subsensitivity is associated with functional impairment in schizophreniaErik Messamore
Behavioral Health and Clinical Neurosciences Division, Portland VA Medical Center, Portland, OR 97239, USA
Schizophr Res 137:180-4. 2012Sensitivity to the skin flush effect of niacin is reduced in a portion of patients with schizophrenia...
- Induction of differentiation in human promyelocytic leukemia HL-60 cell line by niacin-related compoundsKeiko Iwata
Laboratory of Molecular and Cellular Biology, Department of Life Science, Faculty of Bioresources, Mie University, Tsu, Mie 514 8507, Japan
Biosci Biotechnol Biochem 67:1132-5. 2003Water-soluble vitamin, niacin, and its related compounds were examined for their differentiation-inducing activity in human promyelocytic leukemia cells (HL-60)...
- Niacin promotes adipogenesis by reducing production of anti-adipogenic PGF2α through suppression of C/EBPβ-activated COX-2 expressionKo Fujimori
Laboratory of Biodefense and Regulation, Osaka University of Pharmaceutical Sciences, 4 20 1 Nasahara, Takatsuki, Osaka 569 1094, Japan
Prostaglandins Other Lipid Mediat 94:96-103. 2011b>Niacin is converted to NAD and NADP in tissues, whose products are involved in a number of cellular processes; and it is associated with the regulation of adipogenesis...
- Novel mechanisms of niacin to improve HDL function: Role of myeloperoxidaseMoti L Kashyap; Fiscal Year: 2013..Nicotinic acid (Niacin) is a widely used agent in the treatment of dyslipidemia, and clinical trials indicate that the treatment with ..
- A Trial of Zinc and Micronutrients in Tanzanian ChildrenChristopher P Duggan; Fiscal Year: 2010..be recruited and randomly assigned in a factorial design to either zinc, micronutrients (vitamins C, E, B1, B2, niacin, B6, folate, and B12) plus zinc, micronutrients without zinc, or a placebo given daily...
- A Novel Approach to Phosphorus Lowering in Patients with Chronic Kidney DiseaseJoachim H Ix; Fiscal Year: 2013..The lipid drug niacin contains both nicotinamide and nicotinic acid, and we have shown that it lowers Pi in CKD patients...
- CHEMOPREVENTION OF SKIN CANCER PROGRAM PROJECTGeorge Timothy Bowden; Fiscal Year: 2013..abstract_text> ..
- FFA Production From Triglyceride-Rich LipoproteinsJohn M Miles; Fiscal Year: 2013..Subsequent studies have shown that intravenous infusion of niacin, a drug known to suppress FFA release, produced a significant reduction in fractional spillover, whereas insulin ..
- Effect of Extended-Release Niacin on Saphenous Vein Graft AtherosclerosisEmmanouil Brilakis; Fiscal Year: 2013..b>Niacin raises HDL-C, restores the re-endothelialization capacity of EPCs, and slowed the progression of SVG ..
- Discovery and Preclinical Development of Drugs for Anthrax, Plague and TularemiaChristie G Brouillette; Fiscal Year: 2010..These diseases are caused by three of the highest risk bacterial bioterrorism agents, B. anthracis, Y. pestis, and F. tularensis. ..
- ENZYMATIC REACTIONS OF PLASMA LIPOPROTEINSHenry J Pownall; Fiscal Year: 2010..Although niacin and the statin class of hypolipidemic drugs can increase HDL-C, their effects are modest and better HDL therapies ..
- Niacin-mediated migration of monocyte-derived cells in atherosclerosisMOLLY INGERSOLL; Fiscal Year: 2010..protocol to trace migration of monocyte subsets in mouse atherosclerotic plaques, demonstrated that intake of 1% niacin supplemented diet promoted monocyte-derived cell egress from plaques rescuing monocytes from dying in necrotic ..
- Mechanism of HPA Axis Activation: Role of Nicotinic Acid Receptor in the BrainJang H Youn; Fiscal Year: 2012DESCRIPTION (provided by applicant): Nicotinic acid (NA;or niacin) is a water-soluble vitamin...
- Niacin therapy to improve endothelial function in Sickle Cell DiseaseNAOMI L LUBAN; Fiscal Year: 2011..We propose a forearm blood flow physiology study with Niaspan, a slow release form of niacin, previously reported to increase high density lipoprotein (HDL) and apo A-l levels...
- Phospholipid-Arachidonate-Eicosanoid Signaling in SchizophreniaJeffrey K Yao; Fiscal Year: 2013..Further, we propose that phospholipid-arachidonate-eicosanoid (PAE) signaling abnormalities are responsible for niacin subsensitivity (the reduced sensitivity to the skin flush effect of niacin), which is among the most widely-..
- AIM-HIGHRUTH M MCBRIDE; Fiscal Year: 2010..controlled clinical trial designed to test the hypothesis that the drug combination of extended-release (ER-) niacin plus simvastatin is superior to simvastatin alone, at comparable levels of intreatment LDL-cholesterol, for ..
- Niacin's effect on fatty acids and inflammatory markers (NEFA-IM)RICHARD LOUIS DUNBAR; Fiscal Year: 2012..Specific hypotheses related to Niacin's Effects on Fatty Acids and Inflammatory Markers (NEFA-IM) are assessed using a niacin challenge to provoke ..
- AIM HIGH: Niacin Plus Statin to Prevent Vascular EventsJEFFREY LYNN PROBSTFIELD; Fiscal Year: 2010AIM-HIGH is a multicenter controlled clinical trial designed to test whether the drug combination extended release niacin plus simvastatin is superior to simvastatin alone, at comparable levels of in-treatment LDLcholesterol (LDL-C), for ..
- Elucidation of Tissue-Specific Transcriptomic Profiles in Cardiometabolic DiseaseMuredach P Reilly; Fiscal Year: 2013..In the Genetics of Evoked-Responses to Niacin and Endotoxemia (GENE) study, we recruited healthy individuals (N=286) to an inpatient protocol and collected ..
- Effects of Niacin on Lp(a), Oxidized LDL, and inflammation in the AIM-HIGH trialDANIEL JAMES RADER; Fiscal Year: 2013..therapy (to raise HDL-C and lower both triglycerides and LDL-C) with simvastatin plus extended- release niacin (niacin) will reduce cardiovascular events more than LDL-lowering alone with simvastatin in patients with ..
- Plaque Inflammation and Dysfunctional HDL in AIM-HIGHKEVIN DOUGLAS O'BRIEN; Fiscal Year: 2012..changes in HDL that are associated with impairment of its normal function but that are improved with statin+niacin therapy...
- DOES ATHEROSCLEROSIS REGRESS WITH THERAPY FOR LOW HDLC?Bruce Brown; Fiscal Year: 2000..o.) and women (less than 67 y.o.) to double-blinded therapy, assigned in a factorial design: 1) mid-dose niacin (500 mg qid), plus simvastatin (20 mg qd); 2) an antioxidant cocktail (vitamin C (500 mg bid), E (400 IU bid), and ..
- FUNCTIONAL CHARACTERISTICS OF THE LEFT HEARTHAROLD DODGE; Fiscal Year: 1990..natural history of coronary atherosclerotic lesions and the effect of serum lipid lowering with colestepol plus niacin or mevinolin and also cholestyramine on the rate of lesion progression...
- BIOSYNTHESIS OF VITAMIN B1 AND VITAMIN B6IAN SPENSER; Fiscal Year: 2000..coli, since other Vitamins (e.g., thiamin, niacin) have distinct modes of origin in prokaryotes and eukaryotes...
- PROCESSING OF NUTRITIONAL ASPECTS OF BREAST MILKKHEM SHAHANI; Fiscal Year: 1980..to the effects of slow freezing, quick freezing and freeze dehydration and storage upon certin B vitamins (niacin, biotin and pantothenic acid), enzymes such as protease, lysozyme, lipase and lactoperoxidase, and several lipid ..
- Niacin, n-3 fatty acids and insulin resistanceWilliam Harris; Fiscal Year: 2007..In recent studies from our laboratory, niacin and fish oil (n-3 fatty acids, FA) used in combination in individuals with the IRS improved the lipid phenotype, ..
- EVALUATING CORONARY LESION CHARGES USING NEURAL NETWORKSStanley Azen; Fiscal Year: 1993CLAS, a randomized, controlled clinical trial testing niacin/colestipol plus diet therapy in non-smoking men with previous coronary bypass surgery, has demonstrated treatment benefits using both a) a coronary endpoint determination by a ..
- Monitoring Oxygen Repeatedly for Hypoxic Tumor TherapyMohammad Khan; Fiscal Year: 2007..If successful, this approach potentially could be immediately extended for clinical applications. [unreadable] [unreadable] [unreadable]..
- MECHANISMS OF ENZYMATIC REACTIONSPERRY FREY; Fiscal Year: 2006..of epimerase will be to elucidate the molecular basis for the enhancement of the chemical reactivity of the niacin-coenzyme NAD+ by the use of binding energy between substrates and the enzyme...
- HDL AND PLAQUES--NOVEL MODELS AND IMAGING TECHNIQUESEdward Fisher; Fiscal Year: 2001..Plasma lipid levels will be modified by therapy with a statin or statin plus niacin (to raise HDL) and changes in plaque size and composition will be followed serially by MRI...
- A TOPICAL MICRONUTRIENT DELIVERY SYSTEMJaber Qasem; Fiscal Year: 2001..A growing body of evidence demonstrates that micronutrients including vitamins B6, B12, C, E, folate, and niacin are involved in the maintenance of genomic integrity of skin cells via mechanisms ranging from scavenging ROS to ..
- Topical Micronutrient Delivery SystemHyuntae Kim; Fiscal Year: 2005..are to design, synthesize, characterize and evaluate the topical delivery properties of specific pronutrients (niacin, vitamin E, folate, Q1O, and lipoate) to evaluate the safety, tolerance, and efficacy, singly and in combinations ..
- A Transdermal Hypolipidemic Niacin ProdrugHyuntae Kim; Fiscal Year: 2002b>Niacin has been used as first-line drug therapy for elevated serum cholesterol because of its broad efficacy on multiple lipid components as well as its low cost...
- OMEGA-3 FATTY ACIDS IN BIPOLAR DISORDER PROPHYLAXISANDREW STOLL; Fiscal Year: 2002..Plasma and erythrocyte fatty acid content. 2. The niacin skin patch test (a possible marker of in vivo omega-3 fatty acid activity). 3...
- LIPOPROTEIN(A)-CHOLESTEROL ASSAY BY LECTIN PRECIPITATIONLEO SEMAN; Fiscal Year: 1993..Elevated Lp(a) levels can be treated with niacin. Lp(a) differs from other lipoproteins by the presence of a glycoprotein called apolipoprotein(a) [apo(a)], which ..
- BIOCHEMICAL PHARMACOLOGY OF NIACINJason Morrow; Fiscal Year: 1990Nicotinic acid (niacin) is a B vitamin with potent hypolipidemic effects. Niacin administration has been related to a reduction in coronary heart disease mortality and overall mortality after recovery from myocardial infarction...
- ATHEROSCLEROSIS PROGRESSION/REGRESSION IN MANDAVID BLANKENHORN; Fiscal Year: 1990The existing project is a controlled atherosclerosis regression trial using either niacin/colestipol or placebo in men who have had coronary artery bypass surgery...
- EVALUATION OF TAURINE AND NIACIN IN LUNG FIBROSISSHIRI GIRI; Fiscal Year: 1999..The finding that dietary supplementation with taurine and niacin consistently, offers a marked protection against bleomycin (BL)-induced ILF in rodent models has opened a ..
- Does Raising HDL-C with Niacin Improve Endothelial Function in Early CKD?Vandana Menon; Fiscal Year: 2009..b>Niacin is the most effective agent available to increase HDL-C levels and appears to improve endothelial function in non- ..
- Tuning-Up Human MetabolismBruce Ames; Fiscal Year: 2005..g. homocysteine accumulation in MTHFR: riboflavin; alcohol intolerance in half of Asians: niacin. 2) Testing the effectiveness of other metabolites and micronutrients...
- Targeting cofactor biosynthesis in biodefense pathogensAndrei Osterman; Fiscal Year: 2009..In addition to setting the stage for the development of new antibiotics, this study will impact our understanding of an important class of key biosynthetic enzymes in the vitamin/cofactor metabolism of bacterial pathogens. ..
- Effects of Chromium on Progression of Insulin ResistancePeter Havel; Fiscal Year: 2006..The results of these studies will provide valuable information for the design and implementation of new clinical studies examining the effects of chromium supplements in the management of metabolic syndrome in humans. ..
- NON INVASIVE MRI OF HUMAN VULNERABLE PLAQUEValentin Fuster; Fiscal Year: 2001..Plasma lipid levels will be modified by therapy with a statin or statin plus niacin (to raise HDL) and changes in plaque size and composition will be followed serially by MRI...
- Obesity, Inflammation and Thrombosis: LOOK AHEADChristie M Ballantyne; Fiscal Year: 2010....
- MAC 1/LFA 1/P150 95 AND PMN LEUKOCYTE FUNCTIONChristie Ballantyne; Fiscal Year: 2002..3. Characterize the contribution of each CD11 integrin on the host response to common bacterial and fungal pathogens in vitro and in vivo. ..
- Diet/Exercise, Niacin, Fenofibrate for HIV LipodystrophyAshok Balasubramanyam; Fiscal Year: 2008..fat mass and improve hormonal, metabolic and lipoprotein markers associated with insulin resistance; and 2) adding niacin, fenofibrate, or a combination of the two drugs to the intensive lifestyle intervention will result in further ..
- Postprandial Lipemia and Endothelial Function In ACCORDHenry Ginsberg; Fiscal Year: 2004....
- Mentored Career Development in Patient Oriented ResearchDaniel Rader; Fiscal Year: 2006..abstract_text> ..
- Gordon Research Conference: Lipoprotein Metabolism 2004Daniel Rader; Fiscal Year: 2004....
- Mentored Clinical Research Scholar ProgramHenry Ginsberg; Fiscal Year: 2006..They believe firmly that this K12 CRS Program will have an immense impact on the future of patient-oriented research in the next decades. [unreadable] [unreadable] [unreadable]..
- CELLULAR BASIS OF ANTIATHEROGENESIS BY APOLIPOPROTEIN EDaniel Rader; Fiscal Year: 2001..These studies will provide greater understanding of the role of the local inflammatory response in atherosclerosis and its regulation by apoE. ..
- MOLECULAR & CLINICAL EVALUATION OF LOW HDL SYNDROMESMichael Miller; Fiscal Year: 2003..Further understanding of the molecular basis of isolated low HDL-C and its potential clinical sequelae (e.g., CAD), may therefore aid in the development of therapeutic strategies to effectively treat this disorder. ..
- Perfluorocarbon Materials As Drug Delivery VehiclesHans Joachim Lehmler; Fiscal Year: 2004..abstract_text> ..
- MACROPHAGE EXPRESSION OF APOAI AND ATHEROSCLEROSISSergio Fazio; Fiscal Year: 2008..These studies have the potential to uncover the basis for the therapeutic effect of HDL on the arterial plaque. [unreadable] [unreadable] [unreadable] [unreadable]..
- Distribution of PCB AtropisomersHans Joachim Lehmler; Fiscal Year: 2008..The long term career goal is to establish Dr. Lehmler as an investigator with independent research status and funding. ..
- Estrogen and Mechanisms of Cardiomyocyte ProtectionRichard Karas; Fiscal Year: 2009....
- CAROTID PLAQUE COMPOSITION BY MRI DURING LIPID-LOWERINGXue Qiao Zhao; Fiscal Year: 2010..The HDL target for the two niacin-treated groups is to increase 10 mg/dl from baseline...
- HDL metabolism: Influence of extracellular lipasesDaniel Rader; Fiscal Year: 2009....
- NUTRITION ACADEMIC AWARDMichael Miller; Fiscal Year: 2004..Compliance with ATP II and JNC VI recommendations will also be assessed. In addition, medical students' diets and blood lipid levels will be assessed and tracked. ..
- MECHANISM OF PI-RELATED DYSLIPIDEMIA AND ATHEROSCLEROSISDaniel Rader; Fiscal Year: 2004..These studies will provide novel insights into the mechanisms of PI-associated dyslipidemia and atherosclerosis. ..
- P20-Mediated Suppression of Vascular ForceChristopher Rembold; Fiscal Year: 2004..Many current treatments target smooth muscle to reduce tone. It is possible that targeting the force suppression pathway (i.e. p20) might provide comparable benefits. ..
- NO-CGMP INHIBITION OF UROGENITAL SMOOTH MUSCLEChristopher Rembold; Fiscal Year: 2004....
- MOLECULAR BASIS OF HIGH DENSITY LIPOPROTEIN DEFICIENCYERNST SCHAEFER; Fiscal Year: 2009..The results of this work will provide important insight into the contribution of allelic variation in the pathways of HDL metabolism, inflammation, and insulin resistance to the complex phenotype of low HDL-C. ..