ergotamine

Summary

Summary: A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of MIGRAINE DISORDERS.

Top Publications

  1. ncbi Ergotamine and dihydroergotamine: history, pharmacology, and efficacy
    Stephen D Silberstein
    Department of Neurology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Headache 43:144-66. 2003
  2. ncbi The impact of migraine: a case study
    Sharon Jung
    Puget Sound Neurology, Tacoma, WA, USA
    J Neurosci Nurs 39:213-6. 2007
  3. ncbi Ergotamine tartrate and dihydroergotamine mesylate: safety profiles
    R B Lipton
    Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA
    Headache 37:S33-41. 1997
  4. pmc The effect of rizatriptan, ergotamine, and their combination on human peripheral arteries: a double-blind, placebo-controlled, crossover study in normal subjects
    Peer Tfelt-Hansen
    Department of Neurology, Bispebjerg Hospital, Copenhagen, Denmark
    Br J Clin Pharmacol 54:38-44. 2002
  5. ncbi Side effects of ergotamine
    W J Meyler
    Department of Anaesthesiology, University Hospital, Groningen, Netherlands
    Cephalalgia 16:5-10. 1996
  6. ncbi Ergotamine-induced acute vascular insufficiency of the lower limb--a case report
    Z Halloul
    Department of Surgery, University Hospital of Magdeburg, Otto von Guericke University, Germany
    Angiology 52:217-21. 2001
  7. ncbi Patterns of ergotamine and sumatriptan use in the Netherlands from 1991 to 1997
    H Rahimtoola
    SIR Institute of Pharmacy Practice Research, Leiden, The Netherlands
    Cephalalgia 21:596-603. 2001
  8. ncbi Buccal absorption of ergotamine tartrate using the bioadhesive tablet system in guinea-pigs
    Keiko Tsutsumi
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    Int J Pharm 238:161-70. 2002
  9. doi Ergotamine-induced lower extremity arterial vasospasm presenting as acute limb ischemia
    Senay Demir
    Department of Radiology, Başkent University Adana Medical and Research Center, Adana, Turkey
    Diagn Interv Radiol 16:165-7. 2010
  10. ncbi Ergotism associated with HIV antiviral protease inhibitor therapy
    Zachary K Baldwin
    Department of Surgery, Kaiser Permanente Oakland, 280 W MacArthur Boulevard, Oakland, CA 94611, USA
    J Vasc Surg 37:676-8. 2003

Research Grants

Detail Information

Publications186 found, 100 shown here

  1. ncbi Ergotamine and dihydroergotamine: history, pharmacology, and efficacy
    Stephen D Silberstein
    Department of Neurology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Headache 43:144-66. 2003
    b>Ergotamine and dihydroergotamine share structural similarities with the adrenergic, dopaminergic, and serotonergic neurotransmitters. As a result, they have wide-ranging effects on the physiologic processes that they mediate...
  2. ncbi The impact of migraine: a case study
    Sharon Jung
    Puget Sound Neurology, Tacoma, WA, USA
    J Neurosci Nurs 39:213-6. 2007
    ..His headaches became more frequent, and ergotamine and caffeine (Cafergot) suppositories were prescribed...
  3. ncbi Ergotamine tartrate and dihydroergotamine mesylate: safety profiles
    R B Lipton
    Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA
    Headache 37:S33-41. 1997
    b>Ergotamine tartrate (ET) and dihydroergotamine mesylate (DHE) have been widely and effectively used in the treatment of migraine for many decades, although few randomized, controlled clinical trials have been conducted with these ..
  4. pmc The effect of rizatriptan, ergotamine, and their combination on human peripheral arteries: a double-blind, placebo-controlled, crossover study in normal subjects
    Peer Tfelt-Hansen
    Department of Neurology, Bispebjerg Hospital, Copenhagen, Denmark
    Br J Clin Pharmacol 54:38-44. 2002
    To compare the peripheral vasoconstrictor effects of ergotamine, rizatriptan, and their combination, in normal subjects.
  5. ncbi Side effects of ergotamine
    W J Meyler
    Department of Anaesthesiology, University Hospital, Groningen, Netherlands
    Cephalalgia 16:5-10. 1996
    b>Ergotamine has been used for many years in the treatment of migraine, although there is little formal clinical evidence that it is significantly more efficacious than placebo...
  6. ncbi Ergotamine-induced acute vascular insufficiency of the lower limb--a case report
    Z Halloul
    Department of Surgery, University Hospital of Magdeburg, Otto von Guericke University, Germany
    Angiology 52:217-21. 2001
    b>Ergotamine-containing drugs are widely used in the treatment of acute migraine attacks. Spastic vasoconstriction is one of the possible side effects usually affecting the lower extremities and sometimes leading to gangrene...
  7. ncbi Patterns of ergotamine and sumatriptan use in the Netherlands from 1991 to 1997
    H Rahimtoola
    SIR Institute of Pharmacy Practice Research, Leiden, The Netherlands
    Cephalalgia 21:596-603. 2001
    The objective of this study was to assess usage patterns of ergotamine and sumatriptan over a period of 6 years, primarily to evaluate the impact that sumatriptan has had on the prescription of ergotamine...
  8. ncbi Buccal absorption of ergotamine tartrate using the bioadhesive tablet system in guinea-pigs
    Keiko Tsutsumi
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    Int J Pharm 238:161-70. 2002
    The buccal administration of ergotamine tartrate (ET) combined with polyvinyl alcohol (PVA) gel brought about higher plasma concentration of ET compared with that of oral administration of capsules in guinea-pigs...
  9. doi Ergotamine-induced lower extremity arterial vasospasm presenting as acute limb ischemia
    Senay Demir
    Department of Radiology, Başkent University Adana Medical and Research Center, Adana, Turkey
    Diagn Interv Radiol 16:165-7. 2010
    b>Ergotamine-induced limb ischemia is rare and usually results from an accidental overdose. Several agents, including erythromycin and tetracycline, raise serum ergotamine levels and augment its effect...
  10. ncbi Ergotism associated with HIV antiviral protease inhibitor therapy
    Zachary K Baldwin
    Department of Surgery, Kaiser Permanente Oakland, 280 W MacArthur Boulevard, Oakland, CA 94611, USA
    J Vasc Surg 37:676-8. 2003
    ..The HIV-positive population receiving antiviral therapy may be an under-recognized group at risk for ergotism through decreased hepatic metabolism of ergot preparations...
  11. pmc Contractile responses to ergotamine and dihydroergotamine in the perfused middle cerebral artery of rat
    Peer Tfelt-Hansen
    Department of Neurology, Copenhagen University Hospital, Glostrup, Denmark
    J Headache Pain 8:83-9. 2007
    The vasomotor effects of ergotamine and dihydroergotamine (DHE) on the middle cerebral artery (MCA) of rats were studied using the pressurised arteriography method and in vitro myographs...
  12. pmc Interactions of metoclopramide and ergotamine with human 5-HT(3A) receptors and human 5-HT reuptake carriers
    Jan Walkembach
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatskliniken Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Br J Pharmacol 146:543-52. 2005
    The actions of metoclopramide and ergotamine, drugs which are used as a combined migraine medication, on human (h)5-HT3A receptors and 5-HT reuptake carriers, stably expressed in HEK-293 cells, were studied with patch-clamp- and ([3H]5-HT)..
  13. ncbi Aerosol delivery of ergotamine tartrate via a breath-synchronized plume-control inhaler in humans
    T A Armer
    MAP Pharmaceuticals, Mountain View, CA 94043, USA
    Curr Med Res Opin 23:3177-87. 2007
    To compare systemic delivery of ergotamine tartrate (ET) via a breath-synchronized, plume-control inhaler (BSPCI) (Tempo ET) with a sublingual ergot preparation and a commercial inhaler.
  14. doi History of the use of ergotamine and dihydroergotamine in migraine from 1906 and onward
    P C Tfelt-Hansen
    Danish Headache Centre, Department of Neurology, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
    Cephalalgia 28:877-86. 2008
    ..Stoll at Sandoz isolated ergotamine from ergot in 1918...
  15. ncbi Crossover, double-blind clinical trial comparing almotriptan and ergotamine plus caffeine for acute migraine therapy
    M J A Lainez
    Neurology Department, Hospital Clinic Universitari, University of Valencia, Valencia, Spain
    Eur J Neurol 14:269-75. 2007
    ..5 mg and the other with ergotamine 2 mg plus caffeine 200 mg...
  16. ncbi The impact of ergotamine-induced headache and ergotamine withdrawal on information processing
    S Evers
    Department of Neurology, University of Munster, Germany
    Psychopharmacology (Berl) 142:61-7. 1999
    b>Ergotamine abuse and subsequent ergotamine-induced headache is a common problem in the pharmacological treatment of migraine and other headache types; often, withdrawal therapy is necessary...
  17. ncbi Risk of ischemic complications related to the intensity of triptan and ergotamine use
    E A Wammes-van der Heijden
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, The Netherlands
    Neurology 67:1128-34. 2006
    To investigate whether the intensity of triptan and ergotamine use, in specific overuse, is associated with the risk of ischemic complications.
  18. ncbi Crossover comparison of efficacy and preference for rizatriptan 10 mg versus ergotamine/caffeine in migraine
    Suzanne Christie
    Ottawa Headache Centre, Ottawa, Canada
    Eur Neurol 49:20-9. 2003
    ..randomized double- blind crossover outpatient study assessed the preference for 1 rizatriptan 10 mg tablet to 2 ergotamine 1 mg/caffeine 100 mg tablets in 439 patients treating a single migraine attack with each therapy...
  19. ncbi Efficacy, tolerability and safety of oral eletriptan and ergotamine plus caffeine (Cafergot) in the acute treatment of migraine: a multicentre, randomised, double-blind, placebo-controlled comparison
    Hans Christoph Diener
    Department of Neurology, University of Essen, Essen, Germany
    Eur Neurol 47:99-107. 2002
    ..Another commonly prescribed oral treatment for migraine attacks is Cafergot (1 mg ergotamine tartrate with 100 mg caffeine per tablet)...
  20. ncbi Chronic ergot toxicity: A rare cause of lower extremity ischemia
    G D Garcia
    Department of Surgery, Womack Army Medical Center, Ft Bragg, NC, USA
    J Vasc Surg 31:1245-7. 2000
    ..We recommend a conservative approach consisting of observation, antiplatelet agents, and the discontinuance of ergots. If symptoms progress to rest pain or gangrene, surgical treatment should be considered...
  21. ncbi Use of a nonhomologous end joining deficient strain (Deltaku70) of the ergot fungus Claviceps purpurea for identification of a nonribosomal peptide synthetase gene involved in ergotamine biosynthesis
    Thomas Haarmann
    Institut fur Botanik, Westf Wilhelms Universität, Schlossgarten 3, D 48149 Munster, Germany
    Fungal Genet Biol 45:35-44. 2008
    ..The P1 Deltaku70 strain (producing ergotamine and ergocryptine) was used for targeted deletion of lpsA1, one of the two trimodular NRPS genes present in the ..
  22. ncbi [Digitalis -- poisoning, myopathy, ergotism.... When antibiotic and associated therapy become dangerous mixture]
    Katharina Arnheim
    MMW Fortschr Med 145:12-3. 2003
  23. ncbi New treatments in cluster headache
    Todd D Rozen
    Department of Neurology T33, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Curr Neurol Neurosci Rep 2:114-21. 2002
    ..Cluster treatment involves abortive, transitional, and preventive therapy strategies, all of which are discussed in this article...
  24. ncbi Successful treatment of threatening limb loss ischemia of the upper limb caused by ergotamine. A case report and review of the literature
    H A Safar
    Division of Vascular Surgery, Department of Surgery, Hamilton Health Sciences Corporation, General Campus McMaster University, Hamilton, Ontario, Canada
    J Cardiovasc Surg (Torino) 43:245-9. 2002
    We report a case of ischemia limited to the upper limb caused by chronic use of ergotamine. The effect of this drug was not related to hypersensitivity or to the potentiating effects of other medications...
  25. ncbi Possible ergotamine-caffeine-associated delirium
    Scott H Gulbranson
    Good Samaritan Regional Medical Center, Phoenix, Arizona 85006, USA
    Pharmacotherapy 22:126-9. 2002
    ..Daily increased consumption of a product containing ergotamine 1 mg and caffeine 100 mg coincided with both onset and increasing severity of symptoms...
  26. doi Acute migraine therapy: recent evidence from randomized comparative trials
    Anna Mett
    Wolters Kluwer Health Adis, Auckland, New Zealand
    Curr Opin Neurol 21:331-7. 2008
    ..5) It is unclear whether triptans offer clinically relevant benefits over aspirin or NSAIDs in migraine patients. Thus NSAIDs, particularly effervescent aspirin, should be considered the first-line treatment of migraine attacks...
  27. ncbi Ergotamine vs. metoclopramide vs. their combination in acute migraine attacks
    H Hakkarainen
    Department of Neurology, University of Tampere, Finland
    Headache 22:10-2. 1982
    The effect of ergotamine tartrate was compared with that of the antiemetic agent metoclopramide and with those of two combinations in a double-blind trial of 24 adult female patients with migraine...
  28. ncbi [Strategies for antimigraine agents]
    Taketoshi Ishii
    Nihon Yakurigaku Zasshi 131:205-9. 2008
  29. ncbi Reduction in the intensity of abortive migraine drug use during coumarin therapy
    H Rahimtoola
    Department of Pharmacy Practice Research, SIR Institute, Leiden, The Netherlands
    Headache 41:768-73. 2001
    ..All patients using an abortive migraine drug (ergotamine or sumatriptan) and subsequently treated with either coumarin (index group) or low-dose acetylsalicylic acid (..
  30. ncbi An introduction to migraine: from ancient treatment to functional pharmacology and antimigraine therapy
    C M Villalon
    Depto de Farmacobiología, CINVESTAV IPN, Czda de los Tenorios 235, Col Granjas Coapa, Deleg Tlalpan, C P 14330, Mexico D F, Mexico
    Proc West Pharmacol Soc 45:199-210. 2002
    ..v. infusion of 5-HT can abort migraine. In fact, 5-HT as well as ergotamine, dihydroergotamine and other antimigraine agents invariably produce vasoconstriction in the external carotid ..
  31. ncbi Effects of ergotamine and ergovaline on the electromyographic activity of smooth muscle of the reticulum and rumen of sheep
    Lance M McLeay
    Department of Biological Sciences, School of Science and Engineering, The University of Waikato, Private Bag 3105, Hamilton, New Zealand
    Am J Vet Res 67:707-14. 2006
    To investigate the effects of IV administration of ergotamine and ergovaline and intraruminal administration of ergotamine on electromyographic (EMG) activity of reticuloruminal smooth muscle in conscious sheep.
  32. ncbi Medications associated with probable medication overuse headache reported in a tertiary care headache center over a 15-year period
    Chelsea A Meskunas
    Princeton University, Molecular Biology, NJ, USA
    Headache 46:766-72. 2006
    ..To evaluate the substances associated with medication overuse headache (MOH) in a headache center, over the course of the past 15 years...
  33. ncbi Acute migraine treatment: patterns of use and satisfaction in a clinical population
    Shahram N Malik
    Thomas Jefferson University, Jefferson Headache Center, Philadelphia, PA 19107, USA
    Headache 46:773-80. 2006
    ..The sequence and timing of taking migraine medications, whether prescription or over-the-counter, and the patient's response to their treatment, is unknown...
  34. ncbi Cardiovascular, respiratory, and body temperature responses of sheep to the ergopeptides ergotamine and ergovaline
    Lance M McLeay
    Department of Biological Sciences, University of Waikato, Hamilton, New Zealand
    Am J Vet Res 63:387-93. 2002
    To compare the effects of the ergot alkaloid ergovaline with effects of ergotamine on blood pressure, heart rate, respiratory rate, and body temperature in conscious sheep.
  35. ncbi Incidence and determinants of antidepressant drug use in migraine patients
    H Rahimtoola
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
    Int Clin Psychopharmacol 18:331-9. 2003
    ..Our migraine population (2,517 people) included patients having commenced specific migraine drugs, ergotamine or sumatriptan, for the first time from January 1 1992 to December 31 1998...
  36. ncbi Wilfred Harris' early description of cluster headache
    C J Boes
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Cephalalgia 22:320-6. 2002
    ..He was probably one of the first to describe the cluster phenomenon itself and the effectiveness of ergotamine in treating acute attacks of cluster headache...
  37. ncbi Impact of antimigraine compounds on cognitive processing: a placebo-controlled crossover study
    Stefan Evers
    Department of Neurology, University of Munster, Germany
    Headache 43:1102-8. 2003
    ..To evaluate potential cognitive impairment caused by acute antimigraine drugs...
  38. ncbi [Multifocal brain haemorrhage associated with migraine and medication abuse]
    E Páez de la Torre
    Division de Neurologia, Hospital Naval Buenos Aires, Buenos Aires, Argentina
    Rev Neurol 37:840-2. 2003
    ..Although ischemic stroke is a well known complication of migraine, cerebral hemorrhage has been uncommonly reported...
  39. ncbi [Pergolide treatment and cardiac valve pathology: the continuing saga of ergotamine-induced fibrosis]
    J L Montastruc
    Rev Neurol (Paris) 160:19-21. 2004
  40. ncbi [Migraine during pregnancy and lactation: treatment of the acute attack and non-pharmacological prophylactic strategies]
    G Allais
    Centro Cefalee della Donna, III Clinica Ostetrico Ginecologica, Dipartimento di Discipline Ginecologiche e Ostetriche, Universita degli Studi di Torino, CSTNF Centro Studi Terapie Naturali e Fisiche, Torino
    Minerva Med 94:27-38. 2003
    ..For this latter therapy, the personal preliminary positive experience using a predetermined formula of acupoints for the combined treatment of migraine and hyperemesis gravidarum is reported...
  41. ncbi Cost-effectiveness analysis of rizatriptan and sumatriptan versus Cafergot in the acute treatment of migraine
    Lihua Zhang
    Department of Pharmaceutical Economics and Policy, University of Southern California, Los Angeles, California 90089, USA
    CNS Drugs 19:635-42. 2005
    Both ergotamine and selective serotonin 5-HT(1B/1D) receptor agonists ('triptans') are currently used in the treatment of moderate to severe migraine...
  42. ncbi 5-Hydroxtryptamine1D receptor agonism predicts antimigraine efficacy
    A V Deliganis
    Department of Neurology, Stanford University Medical Center, CA 94305-5235
    Headache 31:228-31. 1991
    ..In bovine caudate, the affinities of abortive anti-migraine agents (i.e. 5-hydroxytryptamine, ergotamine, dihydroergotamine, sumatriptan) for 5-HT1D receptors range from 4...
  43. ncbi Relieving migraine pain: sorting through the options
    Lisa K Mannix
    Cleve Clin J Med 70:8-9, 13-4, 16 passim. 2003
    ..Although triptans are a major advance in the treatment of migraine, the optimal approach for acute treatment involves a combination of lifestyle modifications, nonpharmacologic symptom relief, and drug therapy...
  44. ncbi Fatal ergotism induced by an HIV protease inhibitor
    Marc A Tribble
    Headache 42:694-5. 2002
  45. ncbi The treatment of acute migraine
    J Olesen
    Department of Neurology N39, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
    Rev Neurol (Paris) 161:679-80. 2005
    ..The most frequently used drugs are non-steroidal anti-inflammatory drugs and triptans. Ergotamine is less and less used...
  46. ncbi Misunderstood and misdiagnosed: the agony of migraine headache
    Valerie A Miller
    Northwest Georgia Diagnostic Clinic, Gainesville, GA, USA
    Adv Nurse Pract 13:55-6, 58-60, 62. 2005
  47. ncbi [Ergotism in a patient treated with ritonavir and ergotamine]
    César Gallo
    Med Clin (Barc) 119:558-9. 2002
  48. ncbi [Acute ischemia secondary to ergotism]
    J L Pérez Burkhardt
    An Med Interna 21:101-2. 2004
  49. ncbi [Treatment of migraine in patients with hypertension and ischemic heart disease]
    Andrea Ficzere
    Debreceni Egyetem, Orvos és Egészségtudományi Centrum, Neurológiai Klinika, Debrecen
    Ideggyogy Sz 55:25-9. 2002
    ..The article reviews the literature with special focus on hypertension and coronary heart disease. In the second part, the authors summarize their experiences on headache patients...
  50. ncbi A possible dose-dependent teratogenic effect of ergotamine
    N Acs
    Reprod Toxicol 22:551-2. 2006
  51. ncbi Ergotamine use in severe diabetic autonomic neuropathy
    V Toh
    Oxford Centre of Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK
    Diabet Med 23:574-6. 2006
    ..When it does occur, it can prove debilitating and difficult to treat. We report here the therapeutic challenges encountered in managing a patient with severe postural hypotension secondary to diabetes-related autonomic neuropathy...
  52. ncbi Migraine headaches: a historical prospective, a glimpse into the future, and migraine epidemiology
    Jeff Unger
    Chino Medical Group Diabetes and Headache Intervention Center, Quadrant Medical Education, CA, USA
    Dis Mon 52:367-84. 2006
  53. ncbi Ergotamine use in severe diabetic autonomic neuropathy
    T Richardson
    Diabet Med 24:103; author reply 103. 2007
  54. pmc Lack of effect of the antimigraine drugs, sumatriptan, ergotamine and dihydroergotamine on arteriovenous anastomotic shunting in the dura mater of the pig
    M O Den Boer
    Department of Pharmacology, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, The Netherlands
    Br J Pharmacol 107:577-83. 1992
    1. In anaesthetized animals, the antimigraine drugs, sumatriptan, ergotamine and dihydroergotamine, reduce carotid arteriovenous anastomotic shunting...
  55. ncbi Multiple intracerebral hemorrhages and vasospasm following antimigrainous drug abuse
    N Nighoghossian
    Centre de Recherches sur I'Ataxie, , Lyon, France
    Headache 38:478-80. 1998
    ..Multiple intracerebral hemorrhages in migraine may exceptionally be related to vasospasm leading to arterial wall injury. Intracranial arterial vasospasm could be precipitated by excessive vasoactive therapy...
  56. ncbi Trigeminal autonomic cephalalgias. Part 1: cluster headache
    Ramesh Balasubramaniam
    Department of Oral Medicine, University of Pennsylvania, School of Dental Medicine, Philadelphia, PA 19104, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104:345-58. 2007
    ..Aspects of cluster headache including its prevalence and incidence, genetics, pathophysiology, clinical presentation, classification and variants, diagnosis, medical management, and dental considerations are discussed...
  57. ncbi Subcutaneous sumatriptan in the treatment of headache during withdrawal from drug-induced headache
    H C Diener
    Department of Neurology, University of Tuebingen FRG
    Headache 31:205-9. 1991
    ..This result suggests sumatriptan does not act primarily via constriction of the large cerebral arteries...
  58. ncbi Comparison between venoconstrictor effects of sumatriptan and ergotamine in migraine patients
    A Panconesi
    Institute of Internal Medicine IV, University of Florence, Italy
    Headache 34:194-7. 1994
    The vasoconstrictor activity of sumatriptan and ergotamine were compared by injecting these drugs in the hand vein of migraine subjects...
  59. ncbi [Acute and chronic headaches]
    Anne Ducros
    Urgences Cephalees, Hopital Lariboisiere, 75010 Paris
    Rev Prat 56:2161-72. 2006
  60. ncbi Chronic ergot toxicity presenting with bilateral external iliac artery dissection and lower extremity rest pain
    Afshin M Molkara
    Division of Vascular Surgery, Department of Surgery, Loma Linda University Medical Center, Loma Linda, CA 92354, USA
    Ann Vasc Surg 20:803-8. 2006
    ..Endovascular or surgical interventions may be considered in patients with ergot toxicity for specific indications or those whose symptoms progress despite conservative management...
  61. doi Chemical colitis
    Sarah Sheibani
    Division of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5202, USA
    J Clin Gastroenterol 42:115-21. 2008
    ..colitis that are covered in this review include alcohol, radiocontrast agents, glutaraldehyde, formalin, ergotamine, hydrofluoric acid, sulfuric acid, acetic acid, ammonia, soap, sodium hydroxide, hydrogen peroxide, herbal ..
  62. pmc Ergotamine treatment during pregnancy and a higher rate of low birthweight and preterm birth
    Ferenc Banhidy
    Second Department of Obstetrics and Gynecology, Semmelweis University, School of Medicine, Budapest, Hungary
    Br J Clin Pharmacol 64:510-6. 2007
    Previously the association between oral ergotamine treatment during pregnancy and gestational age at delivery, birthweight, the rate of preterm birth and low birthweight has not been studied.
  63. ncbi The impact of different antimigraine compounds on platelet and erythrocyte aggregation
    S Evers
    Department of Neurology, University of Munster, Germany
    Cephalalgia 26:920-4. 2006
    Clinical and experimental data suggest that ergotamine compounds and triptans may contribute to vascular events such as myocardial infarction and stroke. The role of blood cell aggregation in this context is, however, not clarified...
  64. ncbi [Treatment of cluster headache]
    A Pradalier
    , , , 178, rue des Renouillers, 92700 Colombes, France
    Rev Med Interne 22:151-62. 2001
    ..Radiofrequency trigeminal rhizotomy is the treatment of choice with 70% of beneficial effects. Risks and complications have to be discussed in balance with the benefit of the different surgical procedures...
  65. ncbi Ergovaline-induced vasoconstriction in an isolated bovine lateral saphenous vein bioassay
    J L Klotz
    Forage Animal Production Research Unit, USDA ARS, Lexington, KY 40546, USA
    J Anim Sci 85:2330-6. 2007
    ..of this study was to examine the vasoconstrictive potentials of ergovaline and a more documented ergopeptine, ergotamine, using a bovine, lateral (cranial branch) saphenous vein bioassay...
  66. ncbi Effect of withdrawal of misused medication on sleep disturbances in migraine sufferers with chronic daily headache
    R Hering-Hanit
    Headache Unit, Department of Neurology, Meir General Hospital, Sapir Medical Center, Kfar Saba, Israel
    Headache 40:809-12. 2000
    ..BACKGROUND: Misuse of ergotamine and analgesics by migraineurs is one of the causes of chronic daily headache...
  67. ncbi Limb-threatening ischemia due to ergotamine: case report with angiographic evidence
    R Salvesen
    Department of Neurology, University of Tromso, Nordland Sentralsykehus, Bodo, Norway
    Headache 40:320-3. 2000
    ..She had a history of chronic daily headache and had ingested Cafergot compound corresponding to ergotamine 2 to 3 mg daily for the previous 2 or 3 months...
  68. ncbi [Medication-overuse headache]
    Kasja Rabe
    Klinik für Neurologie der Universität Essen
    MMW Fortschr Med 148:37-8. 2006
    ..The treatment of choice in such cases is withdrawal of the medication followed as early as possible by medicinal prophylaxis of the primary headache...
  69. ncbi Painful ANA-positive scleroderma-like disease with acral ulcerations: a case of chronic gangrenous ergotism
    Uwe Wollina
    Department of Dermatology and Allergology, Academic Teaching Hosputal of the Technical University of Dresden, Dresden, Germany
    Int J Low Extrem Wounds 6:148-52. 2007
    ..In this case report, the authors present a 62-year-old woman with history of long-term use of ergotamine alkaloids for the treatment of menstrual pain, who developed a severe painful disease initially misdiagnosed as ..
  70. ncbi Clinically significant drug interactions with agents specific for migraine attacks
    M J Eadie
    Department of Medicine, University of Queensland, Royal Brisbane Hospital, Australia
    CNS Drugs 15:105-18. 2001
    The drugs which provide specific relief from migraine attacks, the ergopeptides (ergotamine and dihydroergotamine) and the various 'triptans' (notably sumatriptan), are often prescribed for persons already taking various migraine ..
  71. ncbi Comparison of intravenous valproate versus intramuscular dihydroergotamine and metoclopramide for acute treatment of migraine headache
    K R Edwards
    Western New England Pain and Headache Center, Southwestern Vermont Medical Center, Bennington, VT 05201, USA
    Headache 41:976-80. 2001
    ..received either 500 mg intravenous valproate or 10 mg metoclopramide intramuscularly followed by 1 mg dihydro- ergotamine. Patients rated severity of headache and the presence or absence of nausea, photophobia, or phonophobia at ..
  72. ncbi Electrospray[+] tandem quadrupole mass spectrometry in the elucidation of ergot alkaloids chromatographed by HPLC: screening of grass or forage samples for novel toxic compounds
    Andreas F Lehner
    University of Kentucky, College of Agriculture, Livestock Disease Diagnostic Center, Lexington, Kentucky 40512 4125, USA
    J Mass Spectrom 40:1484-502. 2005
    ..chromatographic examination of ergot alkaloid standards of lysergic acid, lysergol, ergonovine, ergovaline, ergotamine, ergocornine, ergocryptine and ergocrystine by HPLC...
  73. ncbi Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase
    J L Plassat
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, U 184 de l INSERM, département de neurobiologie, Faculte de Medecine, Strasbourg, France
    Mol Pharmacol 44:229-36. 1993
    ..inhibiting the stimulatory effect of 5-HT were methysergide, methiothepin, mesulergine, metergoline, clozapine, ergotamine, and (+)-butaclamol...
  74. ncbi Interactions between grapefruit juice and cardiovascular drugs
    David G Bailey
    Department of Medicine and Lawson Health Research Institute, London Health Sciences Centre, London, Ontario, Canada
    Am J Cardiovasc Drugs 4:281-97. 2004
    ..Interaction between ergotamine for migraine and grapefruit juice may cause gangrene or stroke...
  75. ncbi Interaction of tryptamine and ergoline compounds with threonine 196 in the ligand binding site of the 5-hydroxytryptamine6 receptor
    F G Boess
    Pharma Division, Preclinical Research, F Hoffman La Roche Ltd, 4070 Basel, Switzerland
    Mol Pharmacol 52:515-23. 1997
    ..The affinity of other N1-unsubstituted ergolines (e.g., ergotamine, lisuride) was reduced 10-30 fold, whereas the affinity of N1-methylated ergolines (e.g...
  76. ncbi Heart failure induced by non-cardiac drugs
    Lars Slørdal
    Department of Laboratory Medicine, Children s and Women s Health, Norwegian University of Science and Technology, Trondheim, Norway
    Drug Saf 29:567-86. 2006
    ..etanercept; antidiabetic drugs such as rosiglitazone, pioglitazone and troglitazone; antimigraine drugs such as ergotamine and methysergide; appetite suppressants such as fenfulramine, dexfenfluramine and phentermine; tricyclic ..
  77. doi Bromocriptine, a dopamine D(2) receptor agonist with the structure of the amino acid ergot alkaloids, induces neurite outgrowth in PC12 cells
    Toru Oda
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto 606 8501, Japan
    Eur J Pharmacol 598:27-31. 2008
    ..Amino acid ergot alkaloids, such as ergocornine and ergotamine, induced neurite outgrowth, but amine ergot alkaloids, including ergometrine and methylergometrine, did not...
  78. ncbi Semiquantitative determination of ergot alkaloids in seed, straw, and digesta samples using a competitive enzyme-linked immunosorbent assay
    J M Schnitzius
    Department of Biomedical Sciences, College of Science, Oregon State University, Corvallis 97331, USA
    J Vet Diagn Invest 13:230-7. 2001
    ..99, with a CV of 2.1%. Ergocryptine, ergocristine, ergocornine, and ergotamine tartrate did not bind strongly to the 15F3...
  79. ncbi Impact of newer pharmacological treatments on quality of life in patients with Parkinson's disease
    David A Gallagher
    Department of Clinical Neurosciences, Royal Free and University College Medical School, London, EnglandInstitute of Neurology, University College London, London, England
    CNS Drugs 22:563-86. 2008
    ..Parkinson's disease, including the oral (pramipexole, ropinirole and piribedil) and transdermal (rotigotine) non-ergotamine-derived dopamine agonists, the novel MAO-B inhibitor rasagiline and the COMT inhibitors tolcapone and entacapone,..
  80. ncbi Ergotism and photosensitization in swine produced by the combined ingestion of Claviceps purpurea sclerotia and Ammi majus seeds
    T A Lopez
    Departamento de Produccion Animal, Estacion Experimental Agropecuaria Balcarce, INTA, Buenos Aires, Argentina
    J Vet Diagn Invest 9:68-71. 1997
    ..purpurea sclerotia. Qualitative analysis demonstrated the presence of ergotamine, ergocristine, and ergonovine...
  81. doi Acute and preventive treatment of cluster headache and other trigeminal autonomic cephalgias
    Gennaro Bussone
    Clinical Neurosciences Department, C Besta National Neurological Institute, Milan, Italy
    Handb Clin Neurol 97:431-42. 2010
    ..commonly used bridge therapies are 7-21 days of prednisone at high and then tapering doses and ergots such as ergotamine tartrate and dihydroergotamine...
  82. doi Chapter 41: the history of neurology in Scandinavia
    Johan A Aarli
    Department of Neurology, Haukeland University Hospital, Bergen, Norway
    Handb Clin Neurol 95:657-66. 2010
    ..documentation exists from the Viking era, describing treatment of seizures and possibly also the effect of ergotamine. The methods were in concordance with medical practice in the rest of Europe...
  83. pmc Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain
    M G Erlander
    Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037
    Proc Natl Acad Sci U S A 90:3452-6. 1993
    ..of 125I-labeled (+)-lysergic acid diethylamide to transiently expressed MR22 in COS-M6 cells was inhibited by ergotamine > methiothepin > 5-carboxamidotryptamine > 5-HT...
  84. ncbi Analysis of endophyte toxins: fescue and other grasses toxic to livestock
    J K Porter
    Toxicology and Mycotoxin Research Unit, Richard B Russell Agricultural Research Center, ARS, USDA, Athens, GA 30613, USA
    J Anim Sci 73:871-80. 1995
    ..Also, both peramine and the ergopeptine alkaloids (ergovaline, ergotamine) have been isolated from A. lolii-infected perennial ryegrass...
  85. doi Cytotoxicity and accumulation of ergot alkaloids in human primary cells
    Dennis Mulac
    NRW Graduate School of Chemistry Universität Münster, Wilhelm Klemm Strasse 10, D 48149 Munster, Germany
    Toxicology 282:112-21. 2011
    ..Of the more than 40 known ergot alkaloids six are found predominantly. These are ergotamine, ergocornine, ergocryptine, ergocristine, ergosine and ergometrine, along with their corresponding isomeric ..
  86. ncbi Detailed examination of fenfluramine-phentermine users with valve abnormalities identified in Fargo, North Dakota
    S E Kimmel
    Department of Medicine, Hospital of the University of Pennsylvania, and Center for Clinical Epidemiology, and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Am J Cardiol 84:304-8. 1999
    ..Two subjects (11%) had other possible etiologies of valve disease: a history of rheumatic fever and prescribed ergotamine. Three subjects (17%) had a history of migraine headaches and 4 (22%) had murmurs noted before using ..
  87. ncbi Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine
    L W Fitzgerald
    CNS Diseases Research, The DuPont Pharmaceuticals Research Laboratories, Experimental Station, Wilmington, Delaware, USA
    Mol Pharmacol 57:75-81. 2000
    ..in carcinoid disease or after long-term exposure to 5-hydroxytryptamine (5-HT)(2)-preferring ergot drugs (ergotamine, methysergide)...
  88. doi Development and validation of an LC-MS method for quantitation of ergot alkaloids in lateral saphenous vein tissue
    Darrin Smith
    Department of Chemistry, Eastern Kentucky University, Richmond, Kentucky 40475, USA
    J Agric Food Chem 57:7213-20. 2009
    ..for simultaneous quantitation of seven ergot alkaloids (lysergic acid, ergonovine, ergovaline, ergocornine, ergotamine, ergocryptine, and ergocristine) in vascular tissue was developed and validated...
  89. ncbi Agonist-trafficking and hallucinogens
    Javier Gonzalez-Maeso
    Departments of Psychiatry, Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Med Chem 16:1017-27. 2009
    ..this neuropsychological state in humans is not induced by closely related chemicals, such as lisuride or ergotamine, despite their similar in vitro activity at the 5-HT2AR...
  90. doi Persistence with migraine prophylactic treatment and acute migraine medication utilization in the managed care setting
    Avin Z Yaldo
    Ortho McNeil Janssen Scientific Affairs, LLC, Titusville, New Jersey, USA
    Clin Ther 30:2452-60. 2008
    ..The aim of this study was to describe persistence with migraine prophylactic treatment and acute migraine medication utilization in patients prescribed migraine prophylaxis...
  91. ncbi Determination of ergot alkaloids: purity and stability assessment of standards and optimization of extraction conditions for cereal samples
    Rudolf Krska
    University of Natural Resources and Applied Life Sciences Vienna, Christian Doppler Laboratory for Mycotoxin Research, Department for Agrobiotechnology IFA Tulln, Konrad Lorenz Strasse 20, 3430 Tulln, Austria
    J AOAC Int 91:1363-71. 2008
    Results obtained from a purity study on standards of the 6 major ergot alkaloids ergometrine, ergotamine, ergosine, ergocristine, ergocryptine, and ergocornine and their corresponding epimers are discussed...
  92. ncbi Successful withdrawal from analgesic abuse in a group of youngsters with chronic daily headache
    R Hering-Hanit
    Department of Neurology, Meir General Hospital, Sapir Medical Centre, Kfar Saba, Israel
    J Child Neurol 16:448-9. 2001
    Abuse of ergotamine and analgesics is common in adults. It coexists with headache and can also induce headaches...
  93. ncbi Baclofen in cluster headache
    R Hering-Hanit
    Department of Neurology, Meir General Hospital, Kfar Saba, and the Sackler Faculty of Medicine, Tel Aviv University, Israel
    Headache 40:48-51. 2000
    ..They are difficult to treat, and reported prophylactic therapies include ergotamine, steroids, methysergide, lithium carbonate, verapamil, valproate, capsaicin, leuprolide, clonidine, ..
  94. ncbi Pharmacological properties of a wide array of ergolines at functional alpha(1)-adrenoceptor subtypes
    Tilo Görnemann
    Institut fur Pharmazie, Freie Universitat Berlin, Konigin Luise Str 2 4, 14195 Berlin, Germany
    Naunyn Schmiedebergs Arch Pharmacol 376:321-30. 2008
    ..The anti-migraine drugs ergotamine and dihydroergotamine, the anti-parkinsonian drug lisuride and the anti-hyperprolactinemic drug terguride ..
  95. ncbi Cost considerations in headache treatment. Part 2: Acute migraine treatment
    R L Von Seggern
    Adelman Headache Center, Greensboro, NC 27403, USA
    Headache 36:493-502. 1996
    ..Triple therapy" combining metoclopramide, a nonsteroidal anti-inflammatory agent, and an ergotamine preparation may improve tolerance and effectiveness of the ergot...
  96. doi Triptans, serotonin agonists, and serotonin syndrome (serotonin toxicity): a review
    P Ken Gillman
    Bucasia, Queensland, Australia
    Headache 50:264-72. 2010
    ..This review considers SS involving serotonin agonists: ergotamine, lysergic acid diethylamide, bromocriptine, and buspirone, as well as triptans, and reviews the experimental ..
  97. ncbi Triptans for acute cluster headache
    Simon Law
    Pain Research and Nuffield Department of Anaesthetics, University of Oxford, West Wing Level 6, John Radcliffe Hospital, Oxford, Oxfordshire, UK, OX3 9DU
    Cochrane Database Syst Rev 4:CD008042. 2010
    ..Alternative therapies such as intranasal lignocaine and ergotamine are not as commonly used and are less well studied...
  98. ncbi Human 5-HT(5) receptors: the 5-HT(5A) receptor is functional but the 5-HT(5B) receptor was lost during mammalian evolution
    R Grailhe
    Center for Neurobiology and Behavior, Columbia University, 722 West 168 Street, New York, NY 10032, USA
    Eur J Pharmacol 418:157-67. 2001
    ..These binding sites displayed the following displacement profile: Ergotamine>Methiothepin>5-CT, Ritanserin>5-HT...
  99. ncbi Human gene S31 encodes the pharmacologically defined serotonin 5-hydroxytryptamine1E receptor
    J M Zgombick
    Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652
    Mol Pharmacol 42:180-5. 1992
    ..profile of the pharmacologically defined 5-HT1E binding site, 5-HT greater than methysergide greater than ergotamine greater than 8-hydroxy-2-(di-n-propylamino)tetralin greater than 5-carboxyamidotryptamine greater than ..
  100. ncbi Centrally active nonhormonal hot flash therapies
    Charles L Loprinzi
    Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Med 118:118-23. 2005
    ..where it was known as Bellergal-S), a combination preparation sedative that consists of low-dose phenobarbital, ergotamine tartrate, and levorotatory alkaloids of belladonna, is an old agent that was popular approximately 20 years ago; ..
  101. ncbi HMO direct costs and health care resources use after implementation of a monthly limit on sumatriptan
    S D Goldfarb
    Managed Care Pharmacy, Advance Paradigm Clinical Services, Hunt Valley, MD, USA
    Am J Health Syst Pharm 56:2206-10. 1999
    ..medical claim with a diagnosis code for migraine or at least two pharmacy claims for sumatriptan, methysergide, ergotamine, dihydroergotamine, or an ergotamine combination product in 1996 or 1997 were eligible for inclusion...

Research Grants20

  1. Structure and function of the 5HT2A/mGluR2 complex in schizophrenia
    Javier Gonzalez Maeso; Fiscal Year: 2010
    ..The characterization of the structure of the neuroreceptor will extend our understanding of the molecular basis of psychosis, and may provide a route to the development of new, more effective drugs for the treatment of schizophrenia. ..
  2. Accessing Natural Products from Silent Biosynthetic Pathways
    ROBERT HENRY CICHEWICZ; Fiscal Year: 2010
    ..antibiotics (penicillins and cyclosporins), cholesterol-lowering agents (statins), and antimigraine drugs (ergotamine)...
  3. Progesterone Receptors and Seizure Susceptibility
    DOODIPALA REDDY; Fiscal Year: 2009
    ....
  4. Progesterone Receptors and Seizure Susceptibility
    Doodipala Samba Reddy; Fiscal Year: 2010
    ....
  5. Prediction of warfarin dosing using clinical and genetic factors
    Stephen E Kimmel; Fiscal Year: 2010
    ....
  6. A randomized trial of interventions to improve warfarin adherence
    Kevin G Volpp; Fiscal Year: 2010
    ....
  7. A randomized trial of interventions to improve warfarin adherence
    Stephen Kimmel; Fiscal Year: 2009
    ....
  8. Patient Oriented Research in Anticoagulation
    Stephen Kimmel; Fiscal Year: 2006
    ..The ultimate goal is to improve the use of a highly efficacious, but underused, drug, and reduce morbidity and mortality in the large proportion of the population at risk for TE. ..
  9. Research:Genetics of complex traits(RMI)
    Stephen Kimmel; Fiscal Year: 2006
    ....
  10. PREDICTORS OF ANTICOAGULATION CONTROL ON WARFARIN
    Stephen Kimmel; Fiscal Year: 2005
    ..The ultimate goal is to improve the use of a highly efficacious, but underused, drug and reduce morbidity and mortality in the large proportion of the population at risk for TE. ..