metergoline

Summary

Summary: A dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for MIGRAINE DISORDERS therapy.

Top Publications

  1. ncbi Metergoline blocks the behavioral and neuroendocrine effects of orally administered m-chlorophenylpiperazine in patients with obsessive-compulsive disorder
    T A Pigott
    Section on Clinical Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892
    Biol Psychiatry 29:418-26. 1991
  2. ncbi Double-blind, placebo-controlled study of single-dose metergoline in depressed patients with seasonal affective disorder
    Erick H Turner
    Section on Biological Rhythms, Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland, USA
    J Clin Psychopharmacol 22:216-20. 2002
  3. ncbi A comparison of the behavioral effects of oral versus intravenous mCPP administration in OCD patients and the effect of metergoline prior to i.v. mCPP
    T A Pigott
    Section on Clinical Neuropharmacology, National Institute of Mental Health, Bethesda, MD
    Biol Psychiatry 33:3-14. 1993
  4. ncbi Metergoline potentiates natural feeding and antagonizes the anorectic action of medical hypothalamic 5-hydroxytryptamine
    P J Currie
    Clarke Institute of Psychiatry, University of Toronto, ON, Canada
    Pharmacol Biochem Behav 53:1023-8. 1996
  5. ncbi Effects of dopamine D1-like receptor agonists on food-maintained operant behavior in rats
    Jonathan L Katz
    Psychobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    Behav Pharmacol 17:303-9. 2006
  6. pmc Systemic morphine produce antinociception mediated by spinal 5-HT7, but not 5-HT1A and 5-HT2 receptors in the spinal cord
    A Dogrul
    Department of Pharmacology, Gülhane Academy of Medicine, Ankara, Turkey
    Br J Pharmacol 149:498-505. 2006
  7. ncbi Feeding behavior after metergoline or GR-46611 injections into the paraventricular nucleus of the hypothalamus in the pigeon
    Renata A Da Silva
    Department of Physiological Sciences CCB, Federal University of Santa Catarina, 88040 900 Florianopolis, SC, Brazil
    Behav Brain Res 179:248-57. 2007
  8. ncbi Anxiolytic-like action of MTEP expressed in the conflict drinking Vogel test in rats is serotonin dependent
    K Stachowicz
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Neuropharmacology 53:741-8. 2007
  9. ncbi Serotonin receptor blockade increases food intake and body weight after total gastrectomy in rats
    Tilman T Zittel
    University Hospital, Department of General and Transplantation Surgery, University of Tubingen, 72076 Tubingen, Germany
    J Surg Res 106:273-81. 2002
  10. ncbi Pharmacotherapy of seasonal affective disorder
    Edda Pjrek
    Department of General Psychiatry at the Medical University of Vienna, Vienna, Austria
    CNS Spectr 10:664-9; quiz 672. 2005

Scientific Experts

Detail Information

Publications144 found, 100 shown here

  1. ncbi Metergoline blocks the behavioral and neuroendocrine effects of orally administered m-chlorophenylpiperazine in patients with obsessive-compulsive disorder
    T A Pigott
    Section on Clinical Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892
    Biol Psychiatry 29:418-26. 1991
    ..Six OCD patients received four separate challenges: placebo, metergoline, m-CPP, and metergoline plus m-CPP; the second group (n = 6) received metergoline and metergoline plus m-CPP in ..
  2. ncbi Double-blind, placebo-controlled study of single-dose metergoline in depressed patients with seasonal affective disorder
    Erick H Turner
    Section on Biological Rhythms, Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland, USA
    J Clin Psychopharmacol 22:216-20. 2002
    ..The authors initially hypothesized that metergoline, a nonspecific serotonin antagonist, would exacerbate depressive symptoms...
  3. ncbi A comparison of the behavioral effects of oral versus intravenous mCPP administration in OCD patients and the effect of metergoline prior to i.v. mCPP
    T A Pigott
    Section on Clinical Neuropharmacology, National Institute of Mental Health, Bethesda, MD
    Biol Psychiatry 33:3-14. 1993
    ..Pretreatment with the potent serotonin (5-HT) antagonist, metergoline, prior to intravenous mCPP was associated with essentially complete blockade of the exacerbation in OCD ..
  4. ncbi Metergoline potentiates natural feeding and antagonizes the anorectic action of medical hypothalamic 5-hydroxytryptamine
    P J Currie
    Clarke Institute of Psychiatry, University of Toronto, ON, Canada
    Pharmacol Biochem Behav 53:1023-8. 1996
    ..5 h postinjection. In separate groups of rats, the serotonergic antagonist metergoline (MET) (2...
  5. ncbi Effects of dopamine D1-like receptor agonists on food-maintained operant behavior in rats
    Jonathan L Katz
    Psychobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    Behav Pharmacol 17:303-9. 2006
    ..The nonselective serotonergic antagonist metergoline produced a significant rightward shift of the SKF 38393 dose-response function, indicating effective antagonism,..
  6. pmc Systemic morphine produce antinociception mediated by spinal 5-HT7, but not 5-HT1A and 5-HT2 receptors in the spinal cord
    A Dogrul
    Department of Pharmacology, Gülhane Academy of Medicine, Ankara, Turkey
    Br J Pharmacol 149:498-505. 2006
    ..One of the most recently identified subtypes of 5 HT receptor is the 5-HT7 receptor. We aimed to examine the role of spinal 5-HT7 receptors in the antinociceptive effects of systemic morphine...
  7. ncbi Feeding behavior after metergoline or GR-46611 injections into the paraventricular nucleus of the hypothalamus in the pigeon
    Renata A Da Silva
    Department of Physiological Sciences CCB, Federal University of Santa Catarina, 88040 900 Florianopolis, SC, Brazil
    Behav Brain Res 179:248-57. 2007
    ..study examined changes in spontaneous behavior of free-feeding pigeons in response to local injections of metergoline (MET, an antagonist of 5-HT(1/2) receptors; 5, 10 and 20 nmol), GR-46611 (GR, a 5-HT(1B/1D) agonist; 0...
  8. ncbi Anxiolytic-like action of MTEP expressed in the conflict drinking Vogel test in rats is serotonin dependent
    K Stachowicz
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Neuropharmacology 53:741-8. 2007
    ..The potential anxiolytic effect of MTEP (1 mg/kg) was inhibited by a nonselective 5-HT receptor antagonist metergoline (2 mg/kg i.p.) and 5-HT2A/2C receptor antagonist ritanserin (0.5 mg/kg i.p...
  9. ncbi Serotonin receptor blockade increases food intake and body weight after total gastrectomy in rats
    Tilman T Zittel
    University Hospital, Department of General and Transplantation Surgery, University of Tubingen, 72076 Tubingen, Germany
    J Surg Res 106:273-81. 2002
    ..Serotonin inhibits food intake, and postprandial serotonin release is increased after total gastrectomy. Serotonin might contribute to early satiety and loss of body weight after total gastrectomy...
  10. ncbi Pharmacotherapy of seasonal affective disorder
    Edda Pjrek
    Department of General Psychiatry at the Medical University of Vienna, Vienna, Austria
    CNS Spectr 10:664-9; quiz 672. 2005
    ..Furthermore, there are no studies specifically addressing bipolar seasonal depression. This article will review the published literature on pharmacotherapy of seasonal affective disorder...
  11. ncbi Estrous cycle and food availability affect feeding induced by amygdala 5-HT receptor blockade
    Graham C Parker
    Department of Psychology, Wayne State University, 71 West Warren Avenue, Detroit, MI 48202, USA
    Pharmacol Biochem Behav 71:701-7. 2002
    We have recently reported that bilateral infusions of the 5-HT receptor antagonist metergoline (MET) into the posterior basolateral amygdala (pBLA) elicit feeding in female rats tested at mid-light cycle...
  12. ncbi Serotonin sets the day state in the neurons that control coupling between the optic lobe circadian pacemakers in the cricket Gryllus bimaculatus
    A S M Saifullah
    Department of Physics, Biology and Informatics, Faculty of Science and Research Institute for Time Studies, Yamaguchi University, Yamaguchi 753 8512, Japan
    J Exp Biol 205:1305-14. 2002
    ..Application of metergoline, a non-selective serotonin-receptor antagonist, increased spontaneous activity and light-evoked responses ..
  13. ncbi Serotonin regulates rhythmic whisking
    Alexis Hattox
    Department of Anatomy and Neurobiology and The Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Neuron 39:343-52. 2003
    ..These findings suggest that serotonin is both necessary and sufficient to generate rhythmic whisker movements and that serotonergic premotoneurons are part of a whisking CPG...
  14. ncbi Midbrain raphe modulation of nonphotic circadian clock resetting and 5-HT release in the mammalian suprachiasmatic nucleus
    J David Glass
    Department of Biological Sciences, Kent State University, Kent, Ohio 44242 0001, USA
    J Neurosci 23:7451-60. 2003
    ..In the present study, targeted injections of the 5-HT1,2,7 antagonist metergoline or the selective 5-HT7 antagonist DR4004 into the DRN or MRN attenuated DRN-electrically stimulated SCN 5-HT ..
  15. ncbi Serotonergic and histaminergic mechanisms involved in intralipid drinking?
    Abegale W Hartfield
    Laboratory of Experimental Psychology, School of Biology, University of Sussex, Brighton, BN1 9QG, UK
    Pharmacol Biochem Behav 76:251-8. 2003
    ..during 30-min sessions and were tested following pretreatment with mepyramine (H1 receptor antagonist), metergoline (5-HT(1/2) receptor antagonist), cyproheptadine (H1 and 5-HT(2A/2B/2C) and muscarinic receptor antagonist), SB ..
  16. ncbi Pharmacological characterisation of the thermogenic effect of bupropion
    Yong Ling Liu
    Department of Physiology, Basic Medical Sciences, St George s Hospital Medical School, Tooting, London, SW17 0RE, UK
    Eur J Pharmacol 498:219-25. 2004
    ..The nonselective 5-hydroxytryptamine (5-HT or serotonin) receptor antagonist, metergoline (1 mg/kg), and the alpha1-adrenoceptor antagonist, prazosin (1 mg/kg), had no effect on the VO2 response to ..
  17. ncbi Involvement of the serotonergic system in orexin-induced behavioral alterations in rats
    Ichiyo Matsuzaki
    Department of Environmental Health, Institute of Community Medicine, University of Tsukuba, Ibaraki 305 8575, Tsukuba, Japan
    Regul Pept 104:119-23. 2002
    ..Serotonin antagonists, ritanserin and metergoline, did not attenuate orexin-induced hyperlocomotion but partly inhibited orexin-induced behavioral alterations...
  18. ncbi Serotonergic activation rescues reproductive function in fasted mice: does serotonin mediate the metabolic effects of leptin on reproduction?
    Shannon D Sullivan
    Department of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Biol Reprod 66:1702-6. 2002
    ..Coadministration of the 5HT 1/2/7 receptor-antagonist metergoline blocked rescue of cycle length by fluoxetine and by leptin...
  19. ncbi Serotonin-induced enhancement of vasopressin and oxytocin secretion in rat neurohypophyseal tissue culture
    M Galfi
    Department of Biology, Faculty of Juhász Gyula Teachers Training College, University of Szeged, Szeged, Hungary
    Regul Pept 127:225-31. 2005
    ..NH hormone secretion could be partially blocked by previous administration of the 5-HT antagonist ketanserin or metergoline. WAY-100635 did not influence the increased VP secretion induced by 5-HT, but the elevated OT production was ..
  20. ncbi Effects of metergoline on symptoms in women with premenstrual dysphoric disorder
    Catherine A Roca
    National Institute of Mental Health, Bethesda, MD 20892 1277, USA
    Am J Psychiatry 159:1876-81. 2002
    ..The authors investigated the role of acute serotonergic modulation in the efficacy of selective serotonin reuptake inhibitors (SSRIs) in women with premenstrual dysphoric disorder...
  21. ncbi Lack of involvement of dopamine and serotonin during the orphanin FQ/Nociceptin (OFQ/N)-induced prolactin secretory response
    Amy Kraska
    Department of Zoology, Center for Neuroscience, Miami University, Oxford, OH 45056, USA
    Life Sci 77:1465-79. 2005
    ..in dose response studies using the selective serotonin antagonist ritansarin and the nonselective antagonist metergoline. Finally, the pharmacological specificity of the prolactin response was examined by pretreating animals with [..
  22. ncbi Novel 5-HT2-like receptor mediates neurogenic relaxation of the guinea-pig proximal colon
    M R Briejer
    Department of Human and Animal Physiology, Wageningen Agricultural University, Netherlands
    Eur J Pharmacol 279:123-33. 1995
    ..The first phase of the curve to 5-HT was inhibited by: metergoline (pA2 = 8.8 +/- 0.3, against 5-methoxytryptamine 9.3 +/- 0...
  23. ncbi 5-Hydroxytryptamine-stimulated inositol phospholipid hydrolysis in the mouse cortex has pharmacological characteristics compatible with mediation via 5-HT2 receptors but this response does not reflect altered 5-HT2 function after 5,7-dihydroxytryptamine l
    P P Godfrey
    MRC Unit, Radcliffe Infirmary, Oxford, England
    J Neurochem 50:730-8. 1988
    ..This response was inhibited by the nonselective 5-HT antagonists methysergide, metergoline, and spiperone...
  24. ncbi Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase
    J L Plassat
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, U 184 de l INSERM, département de neurobiologie, Faculte de Medecine, Strasbourg, France
    Mol Pharmacol 44:229-36. 1993
    ..antagonists in inhibiting the stimulatory effect of 5-HT were methysergide, methiothepin, mesulergine, metergoline, clozapine, ergotamine, and (+)-butaclamol...
  25. pmc Analysis of the 5-HT receptors mediating contractions in the rabbit isolated renal artery
    S Tadipatri
    Department of Pharmacology, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, The Netherlands
    Br J Pharmacol 104:887-94. 1991
    ..4. The contractile effect of 5-HT was unaffected by MDL 72222 (10(-6) M) and metergoline (10(-8) and 10(-7) M), was weakly antagonized by ketanserin and phentolamine (pKB: 6.6 and 6...
  26. ncbi Serotonin receptor subtype mediation of the interoceptive discriminative stimuli induced by 5-methoxy-N,N-dimethyltryptamine
    D G Spencer
    Neurobiology Department, Troponwerke, Koln, Federal Republic of Germany
    Psychopharmacology (Berl) 93:158-66. 1987
    ..carboxylate (BAY K 8644), the buspirone metabolite 1-pyrimidinyl-piperazine (1-PP), methysergide, metergoline, and metitepine...
  27. ncbi Interaction of tryptamine and ergoline compounds with threonine 196 in the ligand binding site of the 5-hydroxytryptamine6 receptor
    F G Boess
    Pharma Division, Preclinical Research, F Hoffman La Roche Ltd, 4070 Basel, Switzerland
    Mol Pharmacol 52:515-23. 1997
    ..g., ergotamine, lisuride) was reduced 10-30 fold, whereas the affinity of N1-methylated ergolines (e.g., metergoline, methysergide, mesulergine) and other ligands, such as methiothepine, clozapine, ritanserin, amitriptyline, and ..
  28. ncbi A peripheral 5-HT1D-like receptor involved in serotonergic induced hindlimb scratching in rats
    H H Berendsen
    Department of CNS Pharmacology, Organon International B V, Oss, The Netherlands
    Eur J Pharmacol 194:201-8. 1991
    ..Hindlimb scratching induced by 5-MeOT was potentiated by the 5-HT receptor antagonists metergoline, methysergide, mesulergine, mianserin, ritanserin and xylamidine. Hindlimb scratching was not induced by i.c.v...
  29. pmc Effects of 5-HT uptake inhibitors, agonists and antagonists on the burying of harmless objects by mice; a putative test for anxiolytic agents
    K Njung'e
    Pharmaceutical Sciences Institute, Aston University, Birmingham
    Br J Pharmacol 104:105-12. 1991
    ..25 mg kg-1) dose of metergoline. Burying inhibition by mCPP was not altered by any of these agents except that it was potentiated by pindolol 5 ..
  30. pmc Presence of vasoconstrictor 5HT1-like receptors revealed by precontraction of rabbit isolated mesenteric artery
    A Choppin
    , Department of Preclinical Research, Bagneux, France
    Br J Pharmacol 114:309-14. 1995
    ..0). 4. Metergoline and rauwolscine (10(-7)-10(-6) M) antagonized the effects of 5-CT in a non-competitive fashion giving pKBapp ..
  31. ncbi Serotonin receptors involved in vasopressin and oxytocin secretion
    H Jørgensen
    Department of Medical Physiology, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    J Neuroendocrinol 15:242-9. 2003
    ..The 5-HT2+6+7 antagonist metergoline in combination with the 5-HT1A+2+7 antagonist methysergide inhibited the stimulatory effect of 5-CT on both ..
  32. pmc Characterization of the 5-HT receptor mediating endothelium-dependent relaxation in porcine vena cava
    M J Sumner
    Peripheral Pharmacology Department, Glaxo Group Research, Ware, Hertfordshire
    Br J Pharmacol 102:938-42. 1991
    ..induced by 5-HT or alpha-methyl-5-HT was antagonized by methysergide, methiothepin, cyproheptadine and metergoline, but not by ketanserin, spiperone, ondansetron, verapamil, cyanopindolol, mesulergine, ICS 205-930, or ..
  33. pmc Human 5-HT7 receptor-induced inactivation of forskolin-stimulated adenylate cyclase by risperidone, 9-OH-risperidone and other "inactivating antagonists"
    Nicole Toohey
    Center for Neuropharmacology and Neuroscience, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Mol Pharmacol 76:552-9. 2009
    ..h5-HT(7)) receptor-inactivating properties of risperidone, 9-OH-risperidone, bromocriptine, methiothepin, metergoline, and lisuride...
  34. pmc Evidence that RU 24969-induced locomotor activity in C57/B1/6 mice is specifically mediated by the 5-HT1B receptor
    S C Cheetham
    Boots Pharmaceuticals Research Department, Nottingham
    Br J Pharmacol 110:1621-9. 1993
    ..antagonist, ondansetron (1 mg kg-1) or the non-selective 5-HT receptor antagonists methysergide (3 mg kg-1) and metergoline (3 mg kg-1). 6. Although spiroxatrine (0...
  35. pmc Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT(2B) receptors
    E Glusa
    Center for Vascular Biology and Medicine, Friedrich Schiller University Jena, Nordhäuser Strasse 78, D 99089 Erfurt, Germany
    Br J Pharmacol 130:692-8. 2000
    ..47) >/= methiothepin (8.32) > LY 53857 (7.84) >/= amoxapine (7.80) >/= loxapine (7.73) >/= metergoline (7.64) >/= mianserin (7.51) >/= rauwolscine (7.39)...
  36. ncbi Activation of nicotinic receptors on GABAergic amacrine cells in the rabbit retina indirectly stimulates dopamine release
    M J Neal
    Department of Pharmacology, King s College London, St Thomas Hospital, UK
    Vis Neurosci 18:55-64. 2001
    ..However, metergoline, a 5HT1/5HT2 receptor antagonist, and ketanserin, a 5HT2A receptor antagonist, but not the 5HT1A antagonist ..
  37. ncbi Discriminative stimulus properties of mCPP: evidence for a 5-HT2C receptor mode of action
    J Gommans
    Department of Psychopharmacology, Faculty of Pharmacy, Universiteit Utrecht, The Netherlands
    Psychopharmacology (Berl) 137:292-302. 1998
    ..Mianserin and methysergide antagonized the mCPP stimulus, whereas ketanserin antagonized it partially. Metergoline, methiothepin and clozapine only marginally antagonized the mCPP stimulus...
  38. ncbi Mechanism of the thermogenic effect of Metabolite 2 (BTS 54 505), a major pharmacologically active metabolite of the novel anti-obesity drug, sibutramine
    Y L Liu
    Department of Physiology, St George s Hospital Medical School, University of London, UK
    Int J Obes Relat Metab Disord 26:1245-53. 2002
    ..To investigate the pharmacological mechanisms underlying the induction of thermogenesis by Metabolite 2 (M2; BTS 54 505), a major pharmacologically active metabolite of the anti-obesity drug, sibutramine...
  39. ncbi Cloning and characterization of the guinea pig 5-HT1F receptor subtype: a comparison of the pharmacological profile to the human species homolog
    N Adham
    Synaptic Pharmaceutical Corporation, Paramus, NJ 07652, USA
    Neuropharmacology 36:569-76. 1997
    ..following rank order of binding affinities: 5-HT > sumatriptan > 1-NP = DHE > alpha-methyl 5-HT > metergoline > methiothepin > 5-CT...
  40. ncbi Specific labelling of serotonin 5-HT(1B) receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H]GR125,743. A pharmacological characterization
    M J Millan
    Psychopharmacology Department, Centre de Recherches de Croissy, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy Seine, Paris, France
    Pharmacol Biochem Behav 71:589-98. 2002
    ..2), N-[3-(1,4-benzodioxan-5-yl)piperidin-4-yl]N-(indan-2yl)amine (S18127; 7.9), metergoline (7.8), (-)-pindolol (7...
  41. ncbi In vivo electrophysiological characterization of 5-HT receptors in the guinea pig head of caudate nucleus and orbitofrontal cortex
    M el Mansari
    Neurobiological Psychiatry Unit, McGill University, Montreal, Quebec, Canada
    Neuropharmacology 36:577-88. 1997
    ..effect of DOI and mCPP was not prevented by acute intravenous administration of the 5-HT1/2 receptor antagonist metergoline (2 mg/kg) and the 5-HT2A/2C receptor antagonist ritanserin (2 mg/kg) in the two regions nor by the selective 5-..
  42. ncbi Role of 5-HT1B, 5-HT2A and 5-HT2C receptors in the generalization of 5-HT receptor agonists to the ethanol cue in the rat
    S Maurel
    CNS Research, Bayer AG, Cologne, Germany
    Behav Pharmacol 9:337-43. 1998
    ..GR 127935 (10 mg/kg, i.p.), as well as the mixed 5-HT(1B/2C) receptor antagonist metergoline (1 mg/kg, i.p.), and the 5-HT2C receptor antagonist SB 206,553 (1 mg/kg, i.p...
  43. pmc Characterization of putative 5-ht7 receptors mediating direct relaxation in Cynomolgus monkey isolated jugular vein
    E Leung
    Institute of Pharmacology, Roche Bioscience, Palo Alto, CA 94304, USA
    Br J Pharmacol 117:926-30. 1996
    ..7), mesulergine (8.1), metergoline (8.0), clozapine (7.8), mianserin (7.7), spiperone (7.3), ritanserin (7.1), methysergide (7...
  44. ncbi Serotonin depletion unmasks serotonergic component of [3H]dihydroalprenolol binding in rat brain
    C A Stockmeier
    Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106
    Mol Pharmacol 36:903-11. 1989
    ..Furthermore, the addition of metergoline, a serotonin antagonist, also blocked the increase in lesioned tissues...
  45. ncbi Study of the behavioural responses related to the potential addictive properties of MDMA in mice
    Patricia Robledo
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    Naunyn Schmiedebergs Arch Pharmacol 369:338-49. 2004
    ..On day 6, following a single administration of MDMA mice received the following monoaminergic antagonists: metergoline (0.1 and 1 mg/kg), ritanserin (0.25 and 1 mg/kg), timolol (2 and 10 mg/kg), prazosin (0...
  46. pmc An endothelial 5-HT receptor that mediates relaxation in guinea-pig isolated jugular vein resembles the 5-HT1D subtype
    P Gupta
    Department of Biomedical Research, Wyeth Research UK Ltd, Maidenhead, Berkshire
    Br J Pharmacol 106:703-9. 1992
    ..1 and 8.6), metergoline (7.4 and 7.5), PAPP (8.2 and 8.2), yohimbine (7.1 and 6.8), rauwolscine (6.8 and 6...
  47. ncbi Selective and nonselective serotonin antagonists block the aversive stimulus properties of MK212 and m-chlorophenylpiperazine (mCPP) in mice
    Ellen A Walker
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Neuropharmacology 49:1210-9. 2005
    ..of conditioned taste aversions was blocked by nonselective serotonin antagonists cyproheptadine, bromo-LSD, metergoline, methysergide and mianserin...
  48. ncbi Dorsal raphe nuclear stimulation of SCN serotonin release and circadian phase-resetting
    J D Glass
    Department of Biological Sciences, Kent State University, Kent, OH, USA
    Brain Res 859:224-32. 2000
    ..Notably, DRN- but not MRN-stimulated 5-HT release was blocked by the 5-HT(1,2,7) antagonist, metergoline, suggesting that the DRN signals to the SCN indirectly via the activation of a 5-HT-responsive multisynaptic ..
  49. ncbi In vivo Schild regression analyses using nonselective 5-HT2C receptor antagonists in a rat operant behavioral assay
    Ellen A Walker
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Psychopharmacology (Berl) 193:187-97. 2007
    ....
  50. ncbi Serotonergic facilitation of acetylcholine release in vivo from rat dorsal hippocampus via serotonin 5-HT3 receptors
    S Consolo
    Laboratory of Cholinergic Neuropharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Neurochem 62:2254-61. 1994
    ..5 mg/kg i.p.) and DAU 6215 (60 micrograms/kg i.p.), but not by the mixed 5-HT1 and 5-HT2 receptor antagonist metergoline (2 mg/kg s.c.)...
  51. ncbi Tissue distribution, metabolism and effects of bufotenine administered to rats
    R W Fuller
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Neuropharmacology 34:799-804. 1995
    ..Bufotenine injection increased serum corticosterone concentration, an effect not blocked by metergoline at a dose that blocked a similar increase elicited by quipazine...
  52. doi Serotonergic-postsynaptic receptors modulate gripping-induced immobility episodes in male taiep rats
    Jose R Eguibar
    Instituto de Fisiologia, Benemerita Universidad Autonoma de Puebla, Mexico
    Synapse 63:737-44. 2009
    ..Although the serotonin antagonists, ketanserine and metergoline, produced a biphasic effect, first a decrease followed by an increase with higher doses, similar effects were ..
  53. doi On the intrinsic regulation of neuropeptide Y release in the mammalian suprachiasmatic nucleus circadian clock
    J David Glass
    Department of Biological Sciences, Kent State University, Kent, OH 44242 0001, USA
    Eur J Neurosci 31:1117-26. 2010
    ..Conversely, similar application of the serotonin antagonist, metergoline, abolished wheel-running-induced SCN NPY release...
  54. ncbi Possible involvement of endogenous 5-HT in aggravation of cerulein-induced acute pancreatitis in mice
    Kentaro Hamada
    UMN Pharma, Inc, Department of Pharmacology, 1 15 8 Jinnan, Shibuya ku Tokyo 150 0041, Japan
    J Pharmacol Sci 105:240-50. 2007
    ..Although the non-selective 5-HT2A/2B/2C antagonists (metergoline, ritanserin, and methysergide) dose-dependently attenuated the hyperenzymemia, they were relatively less potent ..
  55. pmc The human 5-HT7 serotonin receptor splice variants: constitutive activity and inverse agonist effects
    Kurt A Krobert
    MSD Cardiovascular Research Center, University of Oslo, Rikshospitalet University Hospital, Blindern, N 0316 Oslo, Norway
    Br J Pharmacol 135:1563-71. 2002
    ..with antagonist potencies (pK(b)) determined by antagonism of 5-HT-stimulated AC activity (methiothepin >metergoline> mesulergine > or = clozapine > or = spiperone > or = ritanserin > methysergide > ketanserin)...
  56. ncbi Involvement of 5-HT receptor subtypes in the discriminative stimulus properties of mescaline
    J B Appel
    Department of Psychology, University of South Carolina, Columbia 29208
    Eur J Pharmacol 159:41-6. 1989
    ..ketanserin, LY-53857, pirenperone) were followed by saline-lever responding; less selective central 5-HT (metergoline), and DA (SCH-23390, haloperidol) antagonists, did not block the mescaline cue...
  57. ncbi Dopamine agonists, anti-progestins, anti-androgens, long-term-release GnRH agonists and anti-estrogens in canine reproduction: a review
    C Gobello
    Small Animal Clinic, Faculty of Veterinary Medicine, National University of La Plata, Argentina
    Theriogenology 66:1560-7. 2006
    ..Dopamine agonists such as cabergoline, bromocriptine or metergoline are ergoderivative alkaloids that exert an anti-prolactinergic effect via stimulation of D2 pituitary receptors ..
  58. ncbi Serotonin, norepinephrine and dopamine involvement in the antidepressant action of hypericum perforatum
    G Calapai
    Institute of Pharmacology, School of Medicine, University of Messina, Torre Biologica Policlinico Universitario, Italy
    Pharmacopsychiatry 34:45-9. 2001
    ..we evaluated the effects of Ph-50 alone or in association with sulpiride (a dopamine receptor antagonist), metergoline (a serotonin receptor antagonist) and 6-hydroxydopamine (6-OH-DA, destroying norepinephrine-containing neurons) ..
  59. ncbi A neurochemical study of a new mutant mouse presenting myoclonus-like involuntary movement: a possible model of spontaneous serotonergic hyperactivity
    M Ikeda
    Division of Mental Disorder Research, National Institute of Neuroscience, Tokyo, Japan
    Brain Res 495:337-48. 1989
    ..b>Metergoline (5-HT1 and 5-HT2 antagonist) suppressed the locomotor activity, making it difficult to determine if it ..
  60. ncbi Pharmacological study of TA-0910, a new thyrotropin-releasing hormone (TRH) analog (II): Involvement of the DA system in the locomotor stimulating action of TA-0910
    M Yamamura
    Department of Pharmacology, Tanabe Seiyaku Co, Ltd, Osaka, Japan
    Jpn J Pharmacol 55:57-68. 1991
    ..slightly inhibited by phenoxybenzamine, prazosin, clonidine, or naloxone; not affected by propranolol, metergoline, or a low dose of scopolamine; and was enhanced by a high dose of scopolamine...
  61. ncbi The role of the central serotonergic system in pilocarpine-induced seizures: receptor mechanisms
    W Janusz
    Department of Pharmacology, Medical School, Lublin, Poland
    Neurosci Res 7:144-53. 1989
    ..the agonists 1-(3-chlorophenyl)piperazine (mCPP) and 5-methoxytryptamine (5-MT) and the antagonists spiperone, metergoline, methysergide, cyproheptadine and metoclopramide, did not influence pilocarpine-induced seizures...
  62. pmc Nitric oxide is involved in 5-HT-induced relaxations of the guinea-pig colon ascendens in vitro
    M R Briejer
    Department of Human and Animal Physiology, Agricultural University of Wageningen, The Netherlands
    Br J Pharmacol 107:756-61. 1992
    ..The relaxations were inhibited by metergoline (10 nM) and methiothepine (100 nM) and abolished by tetrodotoxin (TTX, 320 nM). Guanethidine (3...
  63. ncbi The effect of intraventricular administration of the 5-HT3 receptor agonist 2-methylserotonin on the release of dopamine in the nucleus accumbens: an in vivo chronocoulometric study
    L H Jiang
    Department of Psychiatry and Behavioral Sciences, State University of New York, Stony Brook 11794 8790
    Brain Res 513:156-60. 1990
    ..was blocked by the selective 5-HT3 antagonist BRL-43694 (granisetron), but not by the 5-HT1/5-HT2 antagonist metergoline. The i.c.v...
  64. ncbi Pharmacological activity of hyperforin acetate in rats
    P Zanoli
    Dipartimento di Scienze Farmaceutiche, Via Campi 183, I 41100 Modena, Italy
    Behav Pharmacol 13:645-51. 2002
    ..The effect was inhibited by the pretreatment of rats with metergoline, a serotoninergic antagonist, but not with CGS-8216, a benzodiazepine receptor antagonist...
  65. ncbi Serotonin and its requirement for maintenance of contractility in muscle fibres isolated from Schistosoma mansoni
    T A Day
    Department of Zoology, Michigan State University, East Lansing 48814
    Parasitology 108:425-32. 1994
    ..The order of potency for antagonists (10 microM) was: methiothepin > metergoline > Ly-278,584 = ketanserin...
  66. ncbi Discriminative stimulus characteristics of BMY 14802 in the pigeon
    S A Vanecek
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor, USA
    J Pharmacol Exp Ther 284:1-9. 1998
    ..I-5-HTP; 5-HT1A/1B agonist RU24969; 5-HT1B/1C agonist m-CPP; 5-HT1C/2 agonist quipazine; 5-HT1C/2 antagonists, metergoline and the atypical antipsychotic clozapine; and 5-HT3 antagonist ondansetron...
  67. pmc Sumatriptan (GR43175) inhibits cyclic-AMP accumulation in dog isolated saphenous vein
    M J Sumner
    Pharmacology Division, Glaxo Group Research Ltd, Ware, Hertfordshire
    Br J Pharmacol 99:219-20. 1990
    ..The response to sumatriptan (1 microM) was antagonised by methiothepin (1 microM), but not by metergoline (0.1 microM), spiperone (1 microM) or ondansetron (GR38032, 1 microM)...
  68. ncbi Lamotrigine has an anxiolytic-like profile in the rat conditioned emotional response test of anxiety: a potential role for sodium channels?
    N R Mirza
    Department of Neuropharmacology, Vernalis PLC, Oakdene Court, 613 Reading Road, Winnersh, Wokingham RG41 5UA, UK
    Psychopharmacology (Berl) 180:159-68. 2005
    ..Many anticonvulsants are used in disorders other than epilepsy. For example, lamotrigine is reported to be effective in post-traumatic stress disorder and mania...
  69. ncbi Further investigations of the serotonergic properties of the ibogaine-induced discriminative stimulus
    S Helsley
    Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, USA
    Prog Neuropsychopharmacol Biol Psychiatry 23:317-26. 1999
    ..6%) and mCPP (76.4%). This substitution was completely antagonized by metergoline, an agent with 5-HT2C antagonist properties. However, metergoline was ineffective against ibogaine itself...
  70. doi Physiology of the canine anoestrus and methods for manipulation of its length
    J de Gier
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan, Utrecht, The Netherlands
    Reprod Domest Anim 43:157-64. 2008
    ..b>Metergoline, a drug which in a low dosage lowers the plasma prolactin concentration via a serotonin-antagonistic pathway, ..
  71. ncbi A single amino acid difference accounts for the pharmacological distinctions between the rat and human 5-hydroxytryptamine1B receptors
    E M Parker
    Department of Biophysics, Bristol Myers Squibb Company, Wallingford, Connecticut 06492
    J Neurochem 60:380-3. 1993
    ..affinity for sumatriptan, N,N-dipropyl-5-carboxamidotryptamine, 5-methoxy-N,N-dimethyltryptamine, methysergide, metergoline, and rauwolscine...
  72. ncbi Inhibition of delayed rectifier K+ channels by dexfenfluramine (Redux)
    S Hu
    Research Department, Novartis Pharmaceuticals Corp, Summit, New Jersey, USA
    J Pharmacol Exp Ther 287:480-6. 1998
    ..was not prevented by either the 5-HT synthesis inhibitor p-chlorophenylalanine or 5-HT receptor antagonist metergoline. d-FF was also tested in cardiac ventricular myocytes that are reportedly abundant in DRK channels and was ..
  73. ncbi Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase
    J A Bard
    Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652
    J Biol Chem 268:23422-6. 1993
    ..serotonergic ligands to displace specific [3H]5-HT binding was: 5-carboxamido-tryptamine > methiothepin > metergoline > 5-HT > 8-hydroxy-2-(di-n-propylamino)tetralin > sumatriptan > ketanserin > zacopride...
  74. ncbi Correlation between 5-HT7 receptor affinity and protection against sound-induced seizures in DBA/2J mice
    A Bourson
    Pharma Division, Preclinical Research, F Hoffmann La Roche, Basel, Switzerland
    Naunyn Schmiedebergs Arch Pharmacol 356:820-6. 1997
    ..unlikely that interactions between the 5-ht5 receptor will protect DBA/2J mice from audiogenic seizures since metergoline and mesulergine which are both active in this in vivo model have no affinity for the 5-ht5 receptor...
  75. ncbi Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype
    F O Levy
    Department of Cell Biology and Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030
    J Biol Chem 267:7553-62. 1992
    ..full agonist (37 nM), 5-carboxamidotryptamine, full agonist (10 nM), sumatriptan, full agonist (50 nM), metergoline, partial agonist (10 nM), methysergide, partial agonist (40 nM), yohimbine, partial agonist (150 nM), metitepin,..
  76. ncbi Muramyl dipeptide (MDP) and 5-HT receptors. Neuroimmunomodulatory effects of MDP are probably not mediated through 5-HT4 or 5-HT1A receptors
    Jan Sevcik
    Institute of Pharmacology, Academy of Sciences of the Czech Republic, Prague
    Immunopharmacol Immunotoxicol 24:43-53. 2002
    ..the height of twitches and this effect was significantly attenuated in the presence of 5-HT antagonist metergoline (1 microM). The effect of 8-OH-DPAT remained unchanged in the presence of MDP (5, 50 or 500 nM). MDP (10 nM-3...
  77. ncbi gp49B1 suppresses stem cell factor-induced mast cell activation-secretion and attendant inflammation in vivo
    Anna M Feldweg
    Department of Medicine, Harvard Medical School, Boston, USA
    Eur J Immunol 33:2262-8. 2003
    ....
  78. ncbi Abortifacient and endocrine effects of metergoline in beagle bitches during the second half of gestation
    Johan O Nöthling
    Department of Production Animal Studies, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort 0110, Republic of South Africa
    Theriogenology 59:1929-40. 2003
    The purpose of this study was to investigate the abortifacient effects of high doses of metergoline when administered to pregnant beagle bitches during the second half of gestation and to define the endocrine effects of this treatment as ..
  79. ncbi Serotonergic mediation of constant light-potentiated nonphotic phase shifting of the circadian locomotor activity rhythm in Syrian hamsters
    Megan E Knoch
    Department of Biological Sciences, Kent State University, Kent, OH 44242, USA
    Am J Physiol Regul Integr Comp Physiol 291:R180-8. 2006
    ..Antagonists with action at 5-HT7 receptors, including ritanserin and metergoline, were without effect...
  80. doi Use of potentiometric detection in (ultra) high performance liquid chromatography and modelling with adsorption/desorption binding kinetics
    D Daems
    University of Antwerp, Department of Chemistry, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    Anal Chim Acta 777:25-31. 2013
    ..The alkaloid metergoline was mostly used as an example...
  81. ncbi Functional characterization of a novel serotonin receptor (5-HTap2) expressed in the CNS of Aplysia californica
    Demian Barbas
    Department de Biochimie, Universite de Montreal, Quebec, Canada
    J Neurochem 80:335-45. 2002
    ..that the order of potencies of various drugs for the inhibition of [3H]LSD binding was: methiothepin > metergoline > 5-CT > PAPP > 5-HT > ketanserin > NAN-190 > 8-OH-DPAT > clozapine...
  82. ncbi Reanalysis of constitutively active rat and human 5-HT7(a) receptors in HEK-293F cells demonstrates lack of silent properties for reported neutral antagonists
    Gonzalo Romero
    Laboratorios Dr Esteve S A, Av Mare de Déu de Montserrat 221, 08041 Barcelona, Spain
    Naunyn Schmiedebergs Arch Pharmacol 374:31-9. 2006
    ..negative intrinsic activity to SB-691673 at the rat 5-HT7(a) receptor, the compounds SB-258719, mesulergine and metergoline displayed some lower negative intrinsic activity (between -38 and -49%)...
  83. ncbi Identification of the cytochrome P450 monooxygenase that bridges the clavine and ergoline alkaloid pathways
    Thomas Haarmann
    Institut fur Botanik, Westfalische Wilhelms Universitat Munster, Schlossgarten 3, 48149 Munster, Germany
    Chembiochem 7:645-52. 2006
    ..amides and alkaloid peptides are two different families of compounds that have the indole-derived tetracyclic metergoline ring system in common...
  84. ncbi Pregnancy termination in the bitch and queen
    Bruce E Eilts
    Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Skip Bertman Drive, Baton Rouge, LA 70803, USA
    Clin Tech Small Anim Pract 17:116-23. 2002
    ..can be used throughout pregnancy, whereas multiple doses of prolactin inhibitors (cabergoline, bromocriptine, metergoline) or dexamethasone can be used in the second half of pregnancy...
  85. pmc Aptamer-based molecular recognition of lysergamine, metergoline and small ergot alkaloids
    Elsa Rouah-Martin
    Laboratory of Systemic Physiological and Ecotoxicological Research SPHERE, Department of Biology, University of Antwerp, Groenenborgerlaan 171, Antwerp B 2020, Belgium
    Int J Mol Sci 13:17138-59. 2012
    ..This system could also be applied to small ergot alkaloids in an ergot contaminated flour sample...
  86. doi Development of suspension polymerized molecularly imprinted beads with metergoline as template and application in a solid-phase extraction procedure toward ergot alkaloids
    Pieterjan Lenain
    Laboratory of Food Analysis, Ghent University, Belgium
    Anal Chem 84:10411-8. 2012
    ..A new imprinting molecule, metergoline, was used as template analogue in the production of suspension polymerized beads...
  87. ncbi The role of tail skin temperature in the facilitation of the tail-flick reflex after spinal transection or interference with descending serotonergic neurotransmission
    P K Eide
    Department of Physiology, University of Bergen, Norway
    Acta Physiol Scand 135:427-33. 1989
    ..injection of the serotonin (5-HT) neurotoxin 5,6-dihydroxytryptamine (5,6-DHT) or the 5-HT receptor antagonist metergoline. Transection of the spinal cord reduced tail-flick latency (the time needed to evoke the tail-flick reflex by ..
  88. ncbi Tryptamine impairs the acquisition of a one-way active avoidance task
    P J Fletcher
    Neuropsychiatric Research Unit, University of Saskatchewan, Saskatoon, Canada
    Pharmacol Biochem Behav 32:317-21. 1989
    ..it was not induced by systemically administered 5-HT, was reversed by the 5-HT antagonists methysergide and metergoline, but was not affected by depletion of brain 5-HT, with PCPA, or by the dopamine antagonist haloperidol...
  89. ncbi Evidence that d-fenfluramine anorexia is mediated by 5-HT1 receptors
    J C Neill
    School of Psychology, University of Birmingham, UK
    Psychopharmacology (Berl) 97:213-8. 1989
    ..d-Fenfluramine's effect was attenuated by the mixed 5-HT1/5-HT2 receptor antagonists, methiothepin and metergoline; by the 5-HT2 receptor antagonist ritanserin; and by (+/-)cyanopindolol, a mixed 5-HT1A/5-HT1B receptor ..
  90. ncbi Involvement of serotonergic mechanisms in the disruption of ovine duodenal migrating myoelectric complex cycles by duodenal acidification
    E C Crichlow
    Department of Veterinary Physiological Sciences, University of Saskatchewan, Saskatoon, Canada
    Digestion 42:44-50. 1989
    ..When the animals were pretreated with the 5-hydrotryptamine (5-HT) antagonists, ritanserin (0.2 mg/kg) and metergoline (0...
  91. ncbi Marked increases in plasma catecholamine concentrations precede hypotension and bradycardia caused by 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in conscious rats
    G Bagdy
    Section on Clinical Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892
    J Pharm Pharmacol 41:270-2. 1989
    ..Neither metergoline pretreatment (0.5 mg kg-1 i.v...
  92. ncbi Potential vascular alpha1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat
    David Centurión
    Departamento de Farmacobiologia, Cinvestav Coapa, Czda de los Tenorios 235, Col Granjas Coapa, 14330 Mexico D F, Mexico
    Eur J Pharmacol 535:234-42. 2006
    ..These ligands included: methiothepin, methysergide and metergoline (5-HT(1)/5-HT2); WAY-100635, buspirone, ipsapirone and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (5-HT(..
  93. ncbi Behavioral effects of (+-) 3,4-methylenedioxyamphetamine (MDA) and (+-) 3,4-methylenedioxymethamphetamine (MDMA) in the pigeon: interactions with noradrenergic and serotonergic systems
    M A Nader
    Behavioral Pharmacology Laboratory, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799
    Psychopharmacology (Berl) 98:183-8. 1989
    ..MDA was at least 1 log unit more potent than the other two compounds. Metergoline (0.1-1...
  94. pmc 5-HT1B receptors modulate the feeding inhibitory effects of enterostatin
    Ling Lin
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Brain Res 1062:26-31. 2005
    ..Rats were implanted with cannulas into the amygdala and the ipsilateral PVN. The 5-HT receptor antagonists metergoline (non-specific receptor subtypes 1 and 2), or ritanserin (selective 2C), or GR55562 (selective l B) was injected ..
  95. ncbi Metergoline, naloxone, and sodium valproate did not modify arginine vasopressin response to insulin-induced hypoglycemia in man
    P Chiodera
    Cattedra di Endocrinologia e Patologia Costituzionale, Universita di Parma, Italy
    J Endocrinol Invest 11:365-9. 1988
    ..For this purpose, the effect of the serotonergic antagonist metergoline (10 mg/day for 4 days po), the GABA-ergic agonist sodium valproate (600 mg in three divided doses po) and the ..
  96. ncbi Effects of serotonin receptor antagonists and agonists on the tail-flick response in mice involve altered tail-skin temperature
    P K Eide
    Department of Physiology, University of Bergen, Norway
    Neuropharmacology 27:889-93. 1988
    ..and tail-skin temperature were measured in mice after administration of serotonin (5-HT) receptor antagonists (metergoline and metitepin) and agonists [5-methoxy-N,N-dimethyltryptamine (5-MeODMT) and 8-hydroxy-2-(di-n-propylamino)..
  97. ncbi Examination of the effects of some 5-HT2 receptor antagonists on central sympathetic outflow and blood pressure in anaesthetised cats
    A G Ramage
    Academic Department of Pharmacology, Royal Free Hospital Medical School, Hampstead, London, United Kingdom
    Naunyn Schmiedebergs Arch Pharmacol 338:601-7. 1988
    ..curves were constructed for the 5-HT2 antagonists cinanserin, ritanserin, cyproheptadine, methiothepin, metergoline and ICI 169,369. These antagonists showed differing effects on the above parameters...
  98. ncbi Anxiolytic-like effect of group III mGlu receptor antagonist is serotonin-dependent
    K Stachowicz
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Neuropharmacology 52:306-12. 2007
    ..anxiolytic-like effect of CPPG, but that effect was abolished by the non-selective antagonist of 5-HT receptors metergoline and the antagonist of 5-HT2A/C receptors ritanserin (both given intraperitoneally at doses of 2 and 0...
  99. ncbi Effects of serotonin antagonists on m-chlorophenylpiperazine-mediated responses in normal subjects
    R S Kahn
    Department of Psychiatry, Montefiore Medical Center Albert Einstein College of Medicine, Bronx, NY
    Psychiatry Res 33:189-98. 1990
    ..o.) and metergoline (4 mg p.o.), could block the hormonal and behavioral effects of MCPP (0.5 mg/kg p.o...
  100. doi Anxiolytic effects of a semipurified constituent of guaraná seeds on rats in the elevated T-maze test
    Camila Marroni Roncon
    Department of Pharmacy and Pharmacology, State University of Maringa, Maringa, PR, Brazil
    Planta Med 77:236-41. 2011
    ..and dopaminergic neurotransmission involvement in the action of PEA during the ETM test, ineffective doses of metergoline (MET; 5-HT (2A/2C) antagonist receptor) or sulpiride (SUL; dopaminergic receptor antagonist) were acutely ..
  101. ncbi Uterine motility in patients with bicornuate uterus
    G C Oliva
    Department of Obstetric and Gynecology, Policlinico A Gemelli Università Cattolica del Sacro Cuore, Rome, Italy
    Int J Gynaecol Obstet 37:7-12. 1992
    ..A similar contractile response was observed in the uteri with two anatomically symmetric horns, whereas a dissimilar response was typical of the uteri with marked anatomic differences between the two horns...

Research Grants38

  1. ENVIRONMENTAL AND PHARMACOLOGICAL CONTROL OF DRUG ABUSE
    Marilyn Carroll; Fiscal Year: 1990
    ..For comparison, a serotonin antagonist, metergoline, will be administered, and neuropeptide Y, a drug that induces feeding, will also be tested...
  2. A Rapid Immunoassay for Detection of Yersinia Pathogens
    John Glass; Fiscal Year: 2002
    ..Furthermore, this prototype assay will be reduced to a production model, validated for regulatory approval, and finalized for manufacture through a joint venture partner. ..
  3. Society for the Stimulus Properties of Drugs Satellite
    Ellen Walker; Fiscal Year: 2005
    ..The SSPD Satellite to the EBPS 2005 Conference promises to coordinate, exchange, and disseminate information to further our understanding of drug abuse. ..
  4. Effects of chemotherapeutic agents on learning and memory in mice
    Ellen Walker; Fiscal Year: 2009
    ..If certain drugs/combinations produce more adverse effects than others do, clinicians can make informed choices about their patients' therapy and improve the quality of life for cancer survivors and their families. ..
  5. Behavioral Pharmacology of Serotonin Inverse Agoinsts
    Ellen Walker; Fiscal Year: 2006
    ..Taken together, these experiments will provide a novel pharmacological and/or behavioral profile for 5-HT2C inverse agonists and neutral antagonists while testing hypotheses generated from in vitro data. ..
  6. Effects of chemotherapeutic agents on learning and memory in mice
    ELLEN ANN WALKER; Fiscal Year: 2010
    ..If certain drugs/combinations produce more adverse effects than others do, clinicians can make informed choices about their patients'therapy and improve the quality of life for cancer survivors and their families. ..
  7. Novel modulation of serotonin receptors
    Milt Teitler; Fiscal Year: 2007
    ..Dysfunctions of these modulating mechanisms may underly the psychopathology of various mental diseases. These studies may lead to the development of novel therapeutics for brain dysfunctions, including schizophrenia and depression. ..
  8. Ethanol Effects on the Mammalian Circadian Clock
    REBECCA A contact PROSSER; Fiscal Year: 2010
    ....
  9. Novel modulation of serotonin receptors
    Milt Teitler; Fiscal Year: 2010
    ..Dysfunctions of these modulating mechanisms may underly the psychopathology of various mental diseases. These studies may lead to the development of novel therapeutics for brain dysfunctions, including schizophrenia and depression. ..
  10. Ethanol Effects in the Mammalian Circadian Clock
    Rebecca Prosser; Fiscal Year: 2007
    ..Future Directions: The results of these studies will provide the basis of a more extensive investigation into the effects of acute and chronic ethanol, and ethanol withdrawal, on the mammalian circadian clock. ..
  11. Novel modulation of serotonin receptors
    Milt Teitler; Fiscal Year: 2009
    ..Dysfunctions of these modulating mechanisms may underly the psychopathology of various mental diseases. These studies may lead to the development of novel therapeutics for brain dysfunctions, including schizophrenia and depression. ..
  12. Human 5HT 1E Serotonin Receptor Drug Development (RMI)
    Milt Teitler; Fiscal Year: 2005
    ..Selective agonists and antagonists for the 5HT1E receptor should, at the least, provide information on the function of this highly expressed receptor, and may lead to novel therapeutics for brain dysfunction. ..
  13. CONSTITUTIVELY ACTIVE SEROTONIIN RECEPTORS
    Milt Teitler; Fiscal Year: 1999
    ....
  14. Molecular Biology of 5HT2A receptor expressing synapses
    Milt Teitler; Fiscal Year: 2005
    ....
  15. CONSTITUTIVELY ACTIVE SEROTONIN RECEPTORS
    Milt Teitler; Fiscal Year: 2005
    ....
  16. Design of Class-specific HDAC Imaging Probes for Positron Emission Tomography
    Jacob M Hooker; Fiscal Year: 2010
    ..These tools will be use to accelerate epigenetic research and will ultimately be translated to human PET imaging and clinicians for diagnosing disease and monitoring treatment. ..
  17. NEUROLOGIC REGULATION OF THE SCN CIRCADIAN CLOCK
    John Glass; Fiscal Year: 2007
    ..The ultimate goal of this work is to aid in the development of strategies for manipulating circadian clock mechanisms to treat these debilitating conditions. ..