pilocarpine

Summary

Summary: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.

Top Publications

  1. ncbi Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy
    Teresa Ravizza
    Department of Neuroscience, Laboratory of Experimental Neurology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Neurobiol Dis 29:142-60. 2008
  2. ncbi The role of muscarinic acetylcholine receptor-mediated activation of extracellular signal-regulated kinase 1/2 in pilocarpine-induced seizures
    Jennifer L Berkeley
    Department of Neurology, Center for Neurodegenerative Disease, Emory University, Whitehead Biomedical Research Building, 615 Michael Street, Atlanta, GA 30322, USA
    J Neurochem 82:192-201. 2002
  3. ncbi Strain differences affect the induction of status epilepticus and seizure-induced morphological changes
    B Xu
    Department of Psychology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1
    Eur J Neurosci 20:403-18. 2004
  4. ncbi Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy
    Andrey M Mazarati
    Department of Pediatrics, Neurology Division, David Geffen School of Medicine, University of California Los Angeles, Box 951752, 22 474 MDCC, Los Angeles, CA 90095 1752, USA
    Neurobiol Dis 34:457-61. 2009
  5. ncbi Effect of changing from concomitant timolol pilocarpine to bimatoprost monotherapy on ocular blood flow and IOP in primary chronic angle closure glaucoma
    Harish C Agarwal
    Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    J Ocul Pharmacol Ther 19:105-12. 2003
  6. ncbi The effects of alpha-tocopherol on hippocampal oxidative stress prior to in pilocarpine-induced seizures
    A R Tome
    State University of Ceara, Campus do Itaperi, Fortaleza, Ceara, Brazil
    Neurochem Res 35:580-7. 2010
  7. ncbi Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy
    Brigitte Voutsinos-Porche
    INSERM U405, Faculty of Medicine, Strasbourg, France
    Neurobiol Dis 17:385-402. 2004
  8. ncbi Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus
    Keun-Hwa Jung
    Neural Stem Cell Laboratory in Clinical Research Institute, Stem Cell Research Center, Department of Neurology, Seoul National University Hospital, Program in Neuroscience, Neuroscience Research Institute of SNUMRC, Seoul, South Korea
    Neurobiol Dis 23:237-46. 2006
  9. ncbi Loss of interneurons innervating pyramidal cell dendrites and axon initial segments in the CA1 region of the hippocampus following pilocarpine-induced seizures
    Celine Dinocourt
    INMED, INSERM U29, Parc Scientifique de Luminy, B.P. 13 13273 Marseille, France
    J Comp Neurol 459:407-25. 2003
  10. ncbi Molecular and functional changes in voltage-dependent Na(+) channels following pilocarpine-induced status epilepticus in rat dentate granule cells
    R K Ellerkmann
    Department of Epileptology, University of Bonn Medical Center, Sigmund-Freud Strasse 25, 53105 Bonn, Germany
    Neuroscience 119:323-33. 2003

Research Grants

  1. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2007
  2. QUANTITATIVE GENETIC STUDY OF SEIZURES
    Thomas N Ferraro; Fiscal Year: 2010
  3. PHARMACOTHERAPY FOR XEROSTOMIA IN SJOGREN'S SYNDROME
    SAMUEL HOPKINS; Fiscal Year: 2005
  4. Neuroactive Steroid Therapy of Catamenial Epilepsy
    DOODIPALA REDDY; Fiscal Year: 2007
  5. GABA-A Receptor Gene Transfer to Prevent Epileptogenesis
    SHELLEY RUSSEK; Fiscal Year: 2004
  6. Efficacy of GluR5 Antogonists Against Soman-Induced Seizures and Neuropathology
    MARIA BRAGA; Fiscal Year: 2007
  7. Seizure-Induced Neurogenesis In The Dentate Gyrus
    CHARLES RIBAK; Fiscal Year: 2007
  8. REGULATION OF GLANDULAR MUCOUS CELL SECRETION
    DAVID CULP; Fiscal Year: 2001
  9. EFFECTS OF LITHIUM ON CHOLINERGIC ACTIVITY
    RICHARD JOPE; Fiscal Year: 1990
  10. Aberrant Neurogenesis in Experimental Temporal Lobe Epilepsy
    Jack Parent; Fiscal Year: 2009

Detail Information

Publications238 found, 100 shown here

  1. ncbi Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy
    Teresa Ravizza
    Department of Neuroscience, Laboratory of Experimental Neurology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Neurobiol Dis 29:142-60. 2008
    ..These data show that specific inflammatory pathways are chronically activated during epileptogenesis and they persist in chronic epileptic tissue, suggesting they may contribute to the etiopathogenesis of TLE...
  2. ncbi The role of muscarinic acetylcholine receptor-mediated activation of extracellular signal-regulated kinase 1/2 in pilocarpine-induced seizures
    Jennifer L Berkeley
    Department of Neurology, Center for Neurodegenerative Disease, Emory University, Whitehead Biomedical Research Building, 615 Michael Street, Atlanta, GA 30322, USA
    J Neurochem 82:192-201. 2002
    b>Pilocarpine-induced seizures are mediated by the M(1) subtype of muscarinic acetylcholine receptor (mAChR), but little is known about the signaling mechanisms linking the receptor to seizures...
  3. ncbi Strain differences affect the induction of status epilepticus and seizure-induced morphological changes
    B Xu
    Department of Psychology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1
    Eur J Neurosci 20:403-18. 2004
    ..We conclude that genetic factors clearly affect seizure development and related morphological changes in both standard laboratory strains and the selectively bred seizure-prone and seizure-resistant strains...
  4. ncbi Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy
    Andrey M Mazarati
    Department of Pediatrics, Neurology Division, David Geffen School of Medicine, University of California Los Angeles, Box 951752, 22 474 MDCC, Los Angeles, CA 90095 1752, USA
    Neurobiol Dis 34:457-61. 2009
    ..We suggest that the observed hyperactivity of the HPA axis may underlie co-morbidity between epilepsy and depression...
  5. ncbi Effect of changing from concomitant timolol pilocarpine to bimatoprost monotherapy on ocular blood flow and IOP in primary chronic angle closure glaucoma
    Harish C Agarwal
    Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    J Ocul Pharmacol Ther 19:105-12. 2003
    ..pressure (IOP) in eyes of primary chronic angle closure glaucoma patients already on concomitant timolol and pilocarpine. Thirty two patients of bilateral primary chronic angle closure glaucoma (PCACG) on topical timolol 0...
  6. ncbi The effects of alpha-tocopherol on hippocampal oxidative stress prior to in pilocarpine-induced seizures
    A R Tome
    State University of Ceara, Campus do Itaperi, Fortaleza, Ceara, Brazil
    Neurochem Res 35:580-7. 2010
    ..It has been suggested that pilocarpine-induced seizures is mediated by an increase in oxidative stress...
  7. ncbi Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy
    Brigitte Voutsinos-Porche
    INSERM U405, Faculty of Medicine, Strasbourg, France
    Neurobiol Dis 17:385-402. 2004
    ..NF-kappaB), and Cyclooxygenase-2 (COX-2) expression together with neurodegeneration in the rat lithium-pilocarpine model...
  8. ncbi Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus
    Keun-Hwa Jung
    Neural Stem Cell Laboratory in Clinical Research Institute, Stem Cell Research Center, Department of Neurology, Seoul National University Hospital, Program in Neuroscience, Neuroscience Research Institute of SNUMRC, Seoul, South Korea
    Neurobiol Dis 23:237-46. 2006
    ..Celecoxib attenuated the likelihood of developing spontaneous recurrent seizures after pilocarpine-induced prolonged seizure...
  9. ncbi Loss of interneurons innervating pyramidal cell dendrites and axon initial segments in the CA1 region of the hippocampus following pilocarpine-induced seizures
    Celine Dinocourt
    INMED, INSERM U29, Parc Scientifique de Luminy, B.P. 13 13273 Marseille, France
    J Comp Neurol 459:407-25. 2003
    In the pilocarpine model of chronic limbic seizures, vulnerability of GABAergic interneurons to excitotoxic damage has been reported in the hippocampal CA1 region...
  10. ncbi Molecular and functional changes in voltage-dependent Na(+) channels following pilocarpine-induced status epilepticus in rat dentate granule cells
    R K Ellerkmann
    Department of Epileptology, University of Bonn Medical Center, Sigmund-Freud Strasse 25, 53105 Bonn, Germany
    Neuroscience 119:323-33. 2003
    ..In the present study, we examined whether an episode of S.E. induced by pilocarpine in vivo alters functional properties and expression of voltage-gated Na(+) channels in dentate granule cells (..
  11. ncbi Signaling pathways involved in pilocarpine-induced mucin secretion in rat submandibular glands
    Lucila Busch
    Pharmacology Unit, School of Dentistry, University of Buenos Aires, Marcelo T de Alvear 2142 C1122AAH, Buenos Aires, Argentina
    Life Sci 80:842-51. 2007
    We have studied the signaling pathways involved in pilocarpine-induced mucin release in rat submandibular slices. Pilocarpine produced a significant increment of PGE2 levels and a positive (r=0.8870) and significant (p=0...
  12. ncbi Volumetric magnetic resonance imaging of functionally relevant structural alterations in chronic epilepsy after pilocarpine-induced status epilepticus in rats
    Heiko G Niessen
    Department of Neurology II, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Epilepsia 46:1021-6. 2005
    After pilocarpine-induced epilepsy in rats, volumetric magnetic resonance imaging (MRI) reveals significant morphologic changes in functionally relevant structures of the brain...
  13. ncbi Lovastatin reduces neuronal cell death in hippocampal CA1 subfield after pilocarpine-induced status epilepticus: preliminary results
    Pauline Rangel
    , , Universidade de Mogi das Cruzes, Mogi das Cruzes, SP, Brazil
    Arq Neuropsiquiatr 63:972-6. 2005
    OBJECTIVE: To further characterize the capacity of lovastatin to prevent hippocampal neuronal loss after pilocarpine-induced status epilepticus (SE) METHOD: Adult male Wistar rats were divided into four groups: (A) control rats, received ..
  14. ncbi Network hyperexcitability within the deep layers of the pilocarpine-treated rat entorhinal cortex
    Philip de Guzman
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, QC H3A 2B4, Canada
    J Physiol 586:1867-83. 2008
    ..50 +/- 0.62 s) in the entorhinal cortex (EC) of brain slices obtained from pilocarpine-treated rats but not in those from age-matched, nonepileptic control (NEC) animals...
  15. ncbi Facilitation of granule cell epileptiform activity by mossy fiber-released zinc in the pilocarpine model of temporal lobe epilepsy
    Olga Timofeeva
    Department of Pharmacology and Cancer Biology, Box 3813, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 1078:227-34. 2006
    ..Hippocampal slices from rats that had experienced pilocarpine-induced status epilepticus and developed a recurrent mossy fiber pathway were used to investigate this ..
  16. ncbi Effects of fluoxetine and venlafaxine and pilocarpine on rat parotid glands
    Silvana da Silva
    Department of Stomatology, School of Dentistry, Pontifical Catholic University of Parana, Curitiba Parana, Brazil
    Med Chem 5:483-90. 2009
    ..volume (CV), of rat parotid salivary glands and salivary flow rate (SFR), as well as the secretagogue action of pilocarpine on this flow...
  17. ncbi Effect of interictal spikes on single-cell firing patterns in the hippocampus
    Jun li Zhou
    Neuroscience Center at Dartmouth, Section of Neurology, Dartmouth Medical School, Lebanon, New Hampshire, USA
    Epilepsia 48:720-31. 2007
    ..The purpose of this study was to determine the effect of IS on single-cell firing patterns in freely moving rats with a prior history of seizures...
  18. ncbi Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent
    Christian Frisch
    Department of Epileptology, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Epilepsy Res 73:173-80. 2007
    ..TPM) dose-dependently protects hippocampal CA1 and CA3 neurons during initial status epilepticus in the rat pilocarpine model of temporal lobe epilepsy by inhibition of mitochondrial transition pore opening...
  19. ncbi Preferential neuron loss in the rat piriform cortex following pilocarpine-induced status epilepticus
    Shaoyun Chen
    Department of Anatomy, Toho University School of Medicine, Omori nishi 5 21 16, Ota ku, Tokyo 143 8540, Japan
    Epilepsy Res 74:1-18. 2007
    ..We used stereological methods to examine the specificity and extent of neuron loss in the PC of pilocarpine-treated rats...
  20. ncbi Glutamate receptor 1-immunopositive neurons in the gliotic CA1 area of the mouse hippocampus after pilocarpine-induced status epilepticus
    Feng Ru Tang
    Epilepsy Research Laboratory, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433
    Eur J Neurosci 21:2361-74. 2005
    ..neurons was demonstrated in the hilus of the dentate gyrus in mice killed on days 1, 7 and 60 after pilocarpine-induced status epilepticus (PISE)...
  21. ncbi Behavioral, biochemical and histological studies in a model of pilocarpine-induced spontaneous recurrent seizures
    Janusz Szyndler
    Department of Experimental and Clinical Pharmacology, Medical University, , 00-927 Warsaw, Poland
    Pharmacol Biochem Behav 81:15-23. 2005
    Although the presence of profound cognitive disturbances in lithium-pilocarpine-induced spontaneous recurrent seizures (SRS) has been well documented, much less is known about changes in emotional behavior, in this model of temporal lobe ..
  22. ncbi Status epilepticus in immature rats leads to behavioural and cognitive impairment and epileptogenesis
    Hana Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Vídeòská 1083, Prague 4, CZ 142 20, Czech Republic
    Eur J Neurosci 19:3255-65. 2004
    ..The present study examined whether SE induced by LiCl-pilocarpine in normal immature brain (at the age of 12 or 25 days; P12 or P25) causes cognitive decline and epileptogenesis,..
  23. ncbi Laserinterferometric assessment of pilocarpine-induced movement of an accommodating intraocular lens: a randomized trial
    Oliver Findl
    Department of Ophthalmology, University of Vienna, Austria
    Ophthalmology 111:1515-21. 2004
    To measure the axial movement of an accommodating intraocular lens (IOL) induced by ciliary muscle contraction after application of pilocarpine.
  24. ncbi Different effects of neuroprotectants FK-506 and cyclosporin A on susceptibility to pilocarpine-induced seizures in rats with brain injured at different developmental stages
    Zuzanna Setkowicz
    Department of Neuroanatomy, Institute of Zoology, Jagiellonian University, 6 Ingardena St, , Poland
    Epilepsy Res 61:63-72. 2004
    ..On postnatal day 60, all the animals received single i.p. pilocarpine injections to evoke epileptic seizures...
  25. ncbi Physical training reverts hippocampal electrophysiological changes in rats submitted to the pilocarpine model of epilepsy
    Ricardo Mario Arida
    Laboratorio de Neurologia Experimental, Universidade Federal de Sao Paulo Escola Paulista de Medicina UNIFESP EPM, Rua Botucatu 862, Vila Clementino, CEP 04023 900 Sao Paulo, Brazil
    Physiol Behav 83:165-71. 2004
    ..exercise on "in vitro" hippocampal electrophysiological parameters observed in rats submitted to the pilocarpine model of epilepsy...
  26. ncbi Long-term changes in susceptibility to pilocarpine-induced status epilepticus following neocortical injuries in the rat at different developmental stages
    Zuzanna Setkowicz
    Department of Neuroanatomy, Institute of Zoology, Jagiellonian University, Ingardena 6, , Poland
    Epilepsy Res 53:216-24. 2003
    ..On postnatal day 60, all the animals and naïve controls received single intraperitoneally pilocarpine injections to evoke status epilepticus...
  27. ncbi In vivo 1H magnetic resonance spectroscopy, T2-weighted and diffusion-weighted MRI during lithium-pilocarpine-induced status epilepticus in the rat
    Pieter van Eijsden
    Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Brain Res 1030:11-8. 2004
    ..In the rat lithium-pilocarpine model of SE, we performed quantified T(2)- and isotropic-diffusion-weighted (DW) magnetic resonance imaging (..
  28. ncbi The GABA uptake inhibitor beta-alanine reduces pilocarpine-induced tremor and increases extracellular GABA in substantia nigra pars reticulata as measured by microdialysis
    Keita Ishiwari
    Department of Psychology, University of Connecticut, Storrs, CT 06269-1020, USA
    J Neurosci Methods 140:39-46. 2004
    ..related to tremor, the present study tested the GABA uptake blocker beta-alanine for its ability to reduce pilocarpine-induced tremulous jaw movements...
  29. ncbi Stimulus-driven versus pilocarpine-induced biometric changes in pseudophakic eyes
    K Kriechbaum
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
    Ophthalmology 112:453-9. 2005
    PURPOSE: Most trials that study the lens movement of accommodative intraocular lens (IOLs) use pilocarpine to stimulate ciliary muscle contraction...
  30. ncbi Effects of latrunculin B on outflow facility, intraocular pressure, corneal thickness, and miotic and accommodative responses to pilocarpine in monkeys
    Mehmet Okka
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin, USA
    Trans Am Ophthalmol Soc 102:251-7; discussion 257-9. 2004
    ..pressure (IOP) without adversely affecting the cornea, and inhibit miotic and accommodative responses to pilocarpine, in ocular normotensive monkeys...
  31. ncbi A 5-month period of epilepsy impairs spatial memory, decreases anxiety, but spares object recognition in the lithium-pilocarpine model in adult rats
    Julien Detour
    INSERM U398, Faculty of Medicine, Strasbourg, France
    Epilepsia 46:499-508. 2005
    In temporal lobe epilepsy (TLE), interictal behavioral disorders affect patients' quality of life. Therefore we studied long-term behavioral impairments in the lithium-pilocarpine (li-pilo) model of TLE.
  32. ncbi Consequences of pilocarpine-induced recurrent seizures in neonatal rats
    Shi Xiu-Yu
    Department of Pediatrics, Qilu Hospital, Shandong University, No 107, Wen Hua Xi Road, Jinan, Shandong 250012, China
    Brain Dev 29:157-63. 2007
    ..For seizure induction, neonatal Wistar rats were intraperitoneally injected with pilocarpine on postnatal day 1 (P1), P4 and P7...
  33. ncbi Prolonged infusion of tetrodotoxin does not block mossy fiber sprouting in pilocarpine-treated rats
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, Palo Alto, California 94305 5342, USA
    Epilepsia 45:452-8. 2004
    ..The present study tested the hypothesis that prolonged, focal infusion of tetrodotoxin would block mossy fiber sprouting after an epileptogenic treatment...
  34. ncbi Down-regulation of BK channel expression in the pilocarpine model of temporal lobe epilepsy
    Luis F Pacheco Otalora
    Department of Biological Sciences at the University of Texas at Brownsville Texas Southmost College, 80 Fort Brown, Brownsville, Texas 78520, USA
    Brain Res 1200:116-31. 2008
    ..subunit of BK channels in the hippocampus and cortex of chronically epileptic rats obtained by the pilocarpine model of MTLE...
  35. ncbi Effects of repeated electroconvulsive shock seizures and pilocarpine-induced status epilepticus on emotional behavior in the rat
    Armando Cardoso
    Faculty of Medicine of Porto, Institute of Anatomy, Alameda Prof Hernani Monteiro, Porto, Portugal
    Epilepsy Behav 14:293-9. 2009
    ..shock (ECS) and compared them with those resulting from prolonged status epilepticus (SE) induced with pilocarpine. Using the open-field and elevated plus-maze tests, we detected the presence of behavioral alterations ..
  36. ncbi Pyrrolidine dithiocarbamate protects the piriform cortex in the pilocarpine status epilepticus model
    Jonna Soerensen
    Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilians University, Munich, Germany
    Epilepsy Res 87:177-83. 2009
    ..epilepticus-associated cell loss in the hippocampus and piriform cortex was evaluated in the rat fractionated pilocarpine model...
  37. ncbi CCR3, CCR2A and macrophage inflammatory protein (MIP)-1a, monocyte chemotactic protein-1 (MCP-1) in the mouse hippocampus during and after pilocarpine-induced status epilepticus (PISE)
    J H Xu
    Epilepsy Research Lab, National Neuroscience Institute, Singapore
    Neuropathol Appl Neurobiol 35:496-514. 2009
    ..protein 1-alpha (MIP-1alpha), monocyte chemotactic protein-1 (MCP-1) in the normal mouse central nervous system (CNS) and in the hippocampus at different time points during and after pilocarpine-induced status epilepticus (PISE).
  38. ncbi Age-dependent mortality in the pilocarpine model of status epilepticus
    Robert E Blair
    Department of Neurology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Neurosci Lett 453:233-7. 2009
    ..Here we employed pilocarpine to induce SE in rats aged between 5 and 28 weeks...
  39. ncbi Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats
    Jingjing Xu
    Department of Neurology, Qilu Hospital, Shandong University, 44, Wenhua Xi Road, Jinan 250012, PR China
    Neurosci Lett 453:58-61. 2009
    ..However, whether ghrelin protects hippocampal neurons against cell death in pilocarpine-induced seizures is unknown...
  40. ncbi Temporal characterization of changes in hippocampal cannabinoid CB(1) receptor expression following pilocarpine-induced status epilepticus
    Katherine W Falenski
    Department of Neurology, Virginia Commonwealth University, PO Box 980599, Richmond, VA 23298, USA
    Brain Res 1262:64-72. 2009
    ..a novel plasticity change of the cannabinoid type 1 (CB(1)) receptor in hippocampi of epileptic rats following pilocarpine-induced status epilepticus (SE)...
  41. ncbi Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to dopamine deficits
    Donnie Eddins
    Dept of Psychiatry and Behavioral Sciences, Duke University Medical Ctr, Durham, NC 27710, USA
    Neurotoxicol Teratol 32:99-108. 2010
    ..acetylcholine receptors to developmental CPF-mediated effects, the effects of developmental nicotine and pilocarpine exposure throughout the first five days after fertilization were determined...
  42. ncbi The role of trace elements in the pathogenesis and progress of pilocarpine-induced epileptic seizures
    J Chwiej
    Department of Applied Nuclear Physics, Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, Al Mickiewicza 30, 30 059, Krakow, Poland
    J Biol Inorg Chem 13:1267-74. 2008
    ..elemental analysis within the areas of the rat brain that undergo neurodegenerative changes in consequence of pilocarpine-induced seizures. Significant changes in levels of selected elements were observed in epileptic animals...
  43. ncbi Pilocarpine and other cholinergic drugs in the management of salivary gland dysfunction
    M M Ferguson
    Department of Oral Medicine and Oral Surgery, University of Otago, New Zealand
    Oral Surg Oral Med Oral Pathol 75:186-91. 1993
    ..Of the pharmacologic agents available, pilocarpine has been used extensively over the last century...
  44. ncbi Altered expression and localization of hippocampal A-type potassium channel subunits in the pilocarpine-induced model of temporal lobe epilepsy
    M M Monaghan
    Neuroscience, Wyeth Discovery Research, CN8000, Princeton, NJ 08543, USA
    Neuroscience 156:550-62. 2008
    ..In rats, systemic administration of pilocarpine induces a model of human temporal lobe epilepsy, wherein a brief period of status epilepticus (SE) triggers ..
  45. ncbi Effects of benzodiazepine and pilocarpine on rat parotid glands: histomorphometric and sialometric study
    M V Zaclikevis
    Department of Stomatology, School of Dentistry, Pontificia Universidade Catolica do Parana, Rua Imaculada Conceição 1155, Prado Velho 80215 901, Curitiba Parana, Brazil
    Med Chem 5:74-8. 2009
    Benzodiazepines are among the most frequently prescribed drugs and are often related with dry mouth. Pilocarpine is a cholinergic agonist that increases salivary flow rate and has been used to treat xerostomia...
  46. ncbi mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice
    Jian Xin Liu
    Epilepsy Research Laboratory, National Neuroscience Institute, Singapore, Singapore
    Epilepsy Res 82:111-23. 2008
    ..PKCbeta2 or PKCgamma expression at the border between the stratum oriens and alveus (O/A border) at 2h during pilocarpine induced status epilepticus (SE), and in the stratum pyramidale in CA1 area at 1 day after pilocarpine induced ..
  47. ncbi Antagonism of peripheral inflammation reduces the severity of status epilepticus
    Nicola Marchi
    Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44106, USA
    Neurobiol Dis 33:171-81. 2009
    ..Systemic inflammation and damage of blood-brain barrier (BBB) are etiologic cofactors in the pathogenesis of pilocarpine SE while acute osmotic disruption of the BBB is sufficient to elicit seizures...
  48. ncbi Up-regulation of D-serine might induce GABAergic neuronal degeneration in the cerebral cortex and hippocampus in the mouse pilocarpine model of epilepsy
    Yong Hong Liu
    Institute of Neurosciences, The Fourth Military Medical University, 710032, Xi an, China
    Neurochem Res 34:1209-18. 2009
    ..By using a mouse pilocarpine model, immunohistochemistry, Fluoro-Jade staining and double-labeling, the present study revealed up-regulation ..
  49. ncbi Electroencephalogram functional connectivity between rat hippocampus and cortex after pilocarpine treatment
    S Tejada
    Department of Biologia Fonamental i Ciències de la Salut, University of the Balearic Islands, IUNICS, Palma de Mallorca, Spain
    Neuroscience 165:621-31. 2010
    The muscarinic agonist pilocarpine has been shown to increase the duration and total number of episodes presenting theta rhythm-simultaneously in hippocampus and cortex-in rats during the waking states...
  50. ncbi Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX
    Lyndsey E Collins
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Pharmacol Biochem Behav 94:561-9. 2010
    ..investigated the ability of adenosine antagonists to reverse the tremorogenic effect of the muscarinic agonist pilocarpine. While the adenosine A(2A) antagonist MSX-3 was incapable of reversing the tremulous jaw movements induced by ..
  51. ncbi Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy
    Claudia Brandt
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, D 30559 Hannover, Germany
    J Neurosci 30:8602-12. 2010
    ..study, it was evaluated whether prolonged administration of the selective NKCC1 inhibitor, bumetanide, after a pilocarpine-induced SE modifies the development of epilepsy in adult female rats...
  52. ncbi Astroglial loss and edema formation in the rat piriform cortex and hippocampus following pilocarpine-induced status epilepticus
    Ji Eun Kim
    Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chunchon, Kangwon Do 200 702, South Korea
    J Comp Neurol 518:4612-28. 2010
    ..study we analyzed aquaporin-4 (AQP4) immunoreactivity in the piriform cortex (PC) and the hippocampus of pilocarpine-induced rat epilepsy model to elucidate the roles of AQP4 in brain edema following status epilepticus (SE)...
  53. ncbi Evidences for pharmacokinetic interaction of riluzole and topiramate with pilocarpine in pilocarpine-induced seizures in rats
    Wojciech Zgrajka
    Department of Toxicology, Institute of Agricultural Medicine, Lublin, Poland
    Epilepsy Res 88:269-74. 2010
    In this study we investigated the effectiveness of two antiepileptic drugs: riluzole and topiramate against pilocarpine-induced seizures, which are considered to be a model of intractable epilepsy commonly used to investigate the ..
  54. ncbi Comorbidity between epilepsy and depression: experimental evidence for the involvement of serotonergic, glucocorticoid, and neuroinflammatory mechanisms
    Eduardo Pineda
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1752, USA
    Epilepsia 51:110-4. 2010
    ..We established that animals that had been subjected to lithium chloride and pilocarpine status epilepticus (SE) and developed spontaneous recurrent seizures, exhibited a set of impairments congruent ..
  55. ncbi Effects of ubiquinone on hydroperoxide concentration and antioxidant enzymatic activities in the rat hippocampus during pilocarpine-induced seizures
    Itala Mônica de Sales Santos
    Laboratory Experimental Research in Biological Sciences, Federal University of Piaui, Piaui, Brazil
    Brain Res 1315:33-40. 2010
    ..the neuroprotective effects of UQ in rats, against the observed oxidative stress during seizures induced by pilocarpine. Wistar rats were treated with either 0.9% saline (i.p., control group), UQ (5, 10 or 20 mg/kg, i.p...
  56. ncbi Mu-calpain mediates hippocampal neuron death in rats after lithium-pilocarpine-induced status epilepticus
    Shuhua Wang
    Department of Neurology, Qilu Hospital, Medical School of Shandong University, Jinan 250012, China
    Brain Res Bull 76:90-6. 2008
    ..In the current study, rats were induced SE by lithium-pilocarpine administration. Our data showed hippocampal neurons death appeared at 6h after SE and sustained for 7 days...
  57. ncbi Different effects of pH on the permeation of pilocarpine and pilocarpine prodrugs across the isolated rabbit cornea
    P Suhonen
    Department of Pharmaceutics, University of Kuopio, P O Box 1627, FIN 70211, Kuopio, Finland
    Eur J Pharm Sci 6:169-76. 1998
    Ocular absorption of pilocarpine and many other ophthalmic drugs can be improved by prodrug derivatization...
  58. ncbi Vesicular acetylcholine transporter knock-down mice are more susceptible to pilocarpine induced status epilepticus
    Patrícia A M Guidine
    Nucleo de Neurociencias, Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Avenida Antonio Carlos 6627, CEP 31270 901 Campus Pampulha, Belo Horizonte, MG, Brazil
    Neurosci Lett 436:201-4. 2008
    The pilocarpine (PILO) animal model of Temporal Lobe Epilepsy (TLE) portrays the most common changes in hippocampal circuitry found in human TLE...
  59. ncbi Long-term expressional changes of Na+ -K+ -Cl- co-transporter 1 (NKCC1) and K+ -Cl- co-transporter 2 (KCC2) in CA1 region of hippocampus following lithium-pilocarpine induced status epilepticus (PISE)
    Xiubin Li
    Neurological Department of the 1st Affiliated Hospital of Sun Yat sen University, Guangzhou, 510080, PR China
    Brain Res 1221:141-6. 2008
    ..to investigate the long-term expression profiles of NKCC1 and KCC2 in CA1 region in the mice model of lithium-pilocarpine induced status epilepticus (PISE) and their relationship with epileptogenesis...
  60. ncbi In vivo and in vitro effects of pilocarpine: relevance to ictogenesis
    Nicola Marchi
    Department of Cerebrovascular Research, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Epilepsia 48:1934-46. 2007
    ..model of status epilepticus (SE) utilizes intraperitoneal administration of the cholinergic agonist pilocarpine preceded by methyl-scopolamine treatment...
  61. ncbi Acquired dendritic channelopathy in temporal lobe epilepsy
    Christophe Bernard
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Science 305:532-5. 2004
    ..Kinase inhibition partly reversed dendritic excitability to control levels. Such acquired channelopathy is likely to amplify neuronal activity and may contribute to the initiation and/or propagation of seizures in TLE...
  62. ncbi Upregulated TWIK-related acid-sensitive K+ channel-2 in neurons and perivascular astrocytes in the hippocampus of experimental temporal lobe epilepsy
    Ji Eun Kim
    Department of Anatomy and Neurobiology and Institute of Epilepsy Research, College of Medicine, Hallym University, Chunchon, South Korea
    Epilepsia 50:654-63. 2009
    ..rectifying K(+) channel (TWIK)-related acid-sensitive K(+) (TASK)-2 channel expressions in epilepsy, we conducted a comparative analysis of TASK-2 channel immunoreactivity in the hippocampus of a pilocarpine-induced rat epilepsy model.
  63. ncbi Changes in phosphorylation of the NMDA receptor in the rat hippocampus induced by status epilepticus
    M Niimura
    Centre for the Neurobiology of Stress, Department of Life Sciences, University of Toronto at Scarborough, Toronto, ON M1C 1A4, Canada
    J Neurochem 92:1377-85. 2005
    Systemic administration of pilocarpine preceded by lithium induces status epilepticus (SE) that results in neurodegeneration and may lead to the development of spontaneous recurrent seizures...
  64. ncbi Cellular and network properties of the subiculum in the pilocarpine model of temporal lobe epilepsy
    Andreas Knopp
    Neuroscience Research Center of the Charit, Humboldt University of Berlin, D-10117 Berlin, Germany
    J Comp Neurol 483:476-88. 2005
    ..Using the pilocarpine model of epilepsy, this study examines the anatomical substrates for network hyperexcitability recorded in the ..
  65. ncbi Correlation between shaking behaviors and seizure severity in five animal models of convulsive seizures
    Marcelo Cairrão Araujo Rodrigues
    Physiology Department, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Epilepsy Behav 6:328-36. 2005
    ..On the other hand, WDS are inversely correlated with SE induced by intracerebral bicuculline and pilocarpine injections. Systemic pilocarpine in animals pretreated with methyl-scopolamine barely induced WDS or HS...
  66. ncbi Expression of different isoforms of protein kinase C in the rat hippocampus after pilocarpine-induced status epilepticus with special reference to CA1 area and the dentate gyrus
    F R Tang
    Epilepsy Research Laboratory, National Neuroscience Institute, Singapore
    Hippocampus 14:87-98. 2004
    At 4 h during pilocarpine-induced status epilepticus (DPISE) in rat, protein kinase C (PKC)beta1, PKCbeta2, and PKCgamma were induced at the border between the stratum oriens and alveus (O/A border) of CA1 in the hippocampus...
  67. ncbi Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat
    Karolien Goffin
    Katholieke Universiteit Leuven, Leuven, Belgium
    Exp Neurol 205:501-5. 2007
    b>Pilocarpine administration to rats results in status epilepticus (SE) and after a latency period to the occurrence of spontaneous seizures...
  68. ncbi Effects of pinealectomy and the treatment with melatonin on the temporal lobe epilepsy in rats
    Eliângela de Lima
    Disciplina de Neurologia Experimental, Universidade Federal de Sao Paulo Escola Paulista de Medicina, CEP 04023 900, Edificio Leal Prado, Sao Paulo, SP, Brazil
    Brain Res 1043:24-31. 2005
    ..the present work was to analyze the effects of pinealectomy in the development of the epilepsy model induced by pilocarpine in adult male rats...
  69. ncbi The delta opioid receptor agonist, SNC80, has complex, dose-dependent effects on pilocarpine-induced seizures in Sprague-Dawley rats
    Suzanne B Bausch
    Department of Pharmacology, Uniformed Services University, Bethesda, MD 20814, USA
    Brain Res 1045:38-44. 2005
    ..SNC80), on behavioral seizures and hippocampal histopathology in the pilocarpine model of temporal lobe epilepsy...
  70. ncbi Protective effect of the organotelluroxetane RF-07 in pilocarpine-induced status epilepticus
    Daniele Suzete Persike
    Departamento Neurologia Neurocirurgia, Disciplina de Neurologia Experimental, Universidade Federal de Sao Paulo, UNIFESP, Sao Paulo, Brazil
    Neurobiol Dis 31:120-6. 2008
    ..the activity of caspase-1, -3 and -8 in the hippocampus of rats exhibiting status epilepticus induced by pilocarpine. All three caspases were activated...
  71. ncbi Massive and specific dysregulation of direct cortical input to the hippocampus in temporal lobe epilepsy
    Chyze W Ang
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:11850-6. 2006
    ..This dysregulated temporoammonic pathway is critically positioned to mediate generation and/or propagation of seizure activity in the hippocampus...
  72. ncbi Neuroprotective effects of erythropoietin in the rat hippocampus after pilocarpine-induced status epilepticus
    Jérémie Nadam
    Laboratory of Integrative Cellular and Molecular Physiology, Centre National de la Recherche Scientifique and Université Claude Bernard Lyon 1 UMR5123, Villeurbanne, France
    Neurobiol Dis 25:412-26. 2007
    ..of hippocampal Epo system components (Epo, Epo-R and betac) during neurodegenerative processes following pilocarpine-induced status epilepticus (SE), and examined whether recombinant human Epo (rHuEpo) could support neuronal ..
  73. ncbi Proteome changes associated with hippocampal MRI abnormalities in the lithium pilocarpine-induced model of convulsive status epilepticus
    Nicholas D E Greene
    Neural Development Unit, UCL Institute of Child Health, University College London, London, UK
    Proteomics 7:1336-44. 2007
    ..The lithium pilocarpine model of status epilepticus (SE) in the rat provides a model in which to investigate the molecular and ..
  74. ncbi Status epilepticus causes a long-lasting redistribution of hippocampal cannabinoid type 1 receptor expression and function in the rat pilocarpine model of acquired epilepsy
    K W Falenski
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Neuroscience 146:1232-44. 2007
    ..to mediate the anticonvulsant effects of cannabinoids in several animal models of seizure, including the rat pilocarpine model of acquired epilepsy...
  75. ncbi Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats
    M B Pereira
    Curso de Farmácia, Faculdade Católica Rainha do Sertão, Rua Juvêncio Alves 660, Centro, Quixadá 63900 00, CE, Brazil
    Neurosci Lett 419:253-7. 2007
    This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats. Glutamate (10 and 20 mg/kg), N-methyl-d-aspartate (NMDA, 5 and 10 mg/kg), ketamine (1...
  76. ncbi Synaptic plasticity of the CA3 commissural projection in epileptic rats: an in vivo electrophysiological study
    Claudio M T Queiroz
    Department of Physiology, UNIFESP EPM, Rua Botucatu, 862 04023 062, Sao Paulo, SP, Brazil
    Eur J Neurosci 25:3071-9. 2007
    ..performed in epileptic rats 24 h after an early behavioural spontaneous seizure between 5 and 21 days after pilocarpine-induced status epilepticus...
  77. ncbi Long-term decrease in calbindin-D28K expression in the hippocampus of epileptic rats following pilocarpine-induced status epilepticus
    Dawn S Carter
    Department of Neurology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, United States
    Epilepsy Res 79:213-23. 2008
    ..This study evaluated the expression of hippocampal calbindin levels in the rat pilocarpine model of AE. Calbindin protein expression was reduced over 50% in the hippocampus in epileptic animals...
  78. ncbi Deep brain stimulation of the anterior nucleus of the thalamus: effects of electrical stimulation on pilocarpine-induced seizures and status epilepticus
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital and University Health Network, University of Toronto, Toronto, Ontario, Canada
    Epilepsy Res 78:117-23. 2008
    ..As the optimal stimulation settings remain elusive, we studied the effects of different stimulation parameters against pilocarpine induced seizures and status epilepticus (SE).
  79. ncbi Stereological methods reveal the robust size and stability of ectopic hilar granule cells after pilocarpine-induced status epilepticus in the adult rat
    Daniel P McCloskey
    Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, Route 9W, West Haverstraw, NY 10993, USA
    Eur J Neurosci 24:2203-10. 2006
    ..total number of ectopic hilar granule cells was estimated using unbiased stereology at different times after pilocarpine-induced status epilepticus...
  80. ncbi Bilateral anterior thalamic nucleus lesions and high-frequency stimulation are protective against pilocarpine-induced seizures and status epilepticus
    Clement Hamani
    Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Neurosurgery 54:191-5; discussion 195-7. 2004
    ..was to investigate the influence of anterior thalamic nucleus lesions and high-frequency stimulation in the pilocarpine model of secondarily generalized seizures in rats...
  81. ncbi Differential paired-pulse responses between the CA1 region and the dentate gyrus are related to altered CLC-2 immunoreactivity in the pilocarpine-induced rat epilepsy model
    Sung Eun Kwak
    Department of Anatomy, College of Medicine, Hallym University, Chunchon, Kangwon Do 200 702, South Korea
    Brain Res 1115:162-8. 2006
    ..paired-pulse response and voltage gated Cl(-) channel 2 (CLC-2)/vesicular GABA transport (VGAT) expression in a pilocarpine-induced rat model...
  82. ncbi Distribution and differential regulation of galanin receptor subtypes in rat brain: effects of seizure activity
    Xiaoying Lu
    Department of Neuropharmacology, The Harold L Dorris Neurological Research Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropeptides 39:147-52. 2005
    ....
  83. ncbi Modulation of CaM kinase II activity is coincident with induction of status epilepticus in the rat pilocarpine model
    Michael W Singleton
    Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia 23298-0599, USA
    Epilepsia 46:1389-400. 2005
    ..METHODS: The pilocarpine model of SE was characterized both behaviorally and electrographically...
  84. ncbi Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, 4412 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109 0585, USA
    Ann Neurol 59:81-91. 2006
    ..and immunohistochemistry were used to identify proliferating progenitors and mature DGCs in the adult rat pilocarpine temporal lobe epilepsy model. We also examined dentate gyri from epileptic human hippocampal surgical specimens...
  85. ncbi Minimal latency to hippocampal epileptogenesis and clinical epilepsy after perforant pathway stimulation-induced status epilepticus in awake rats
    Argyle V Bumanglag
    Departments of Pharmacology and Neurology, Graduate Program in Neuroscience, University of Arizona College of Medicine, Tucson, Arizona 85724, USA
    J Comp Neurol 510:561-80. 2008
    ..We hypothesize that the latent period is directly related and inversely proportional to the extent of neuron loss in brain regions involved in seizure initiation, spread, and clinical expression...
  86. ncbi Deficit of Kcnma1 mRNA expression in the dentate gyrus of epileptic rats
    Boris Ermolinsky
    Department of Biological Sciences, The University of Texas, Brownsville Texas Southmost College, Brownsville, Texas, USA
    Neuroreport 19:1291-4. 2008
    ..of Kcnma1 coding for the large-conductance calcium-activated potassium (BK, MaxiK) channel alpha-subunits after pilocarpine-induced status epilepticus...
  87. ncbi Pilocarpine seizures cause age-dependent impairment in auditory location discrimination
    John C Neill
    Children s Hospital, Boston, USA
    J Exp Anal Behav 84:357-70. 2005
    ..Male Sprague-Dawley rats were injected with saline on postnatal day (P) 20, or a convulsant dose of pilocarpine on P20 or P45...
  88. ncbi Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy
    Dong Liang Ma
    Epilepsy Research Laboratory, National Neuroscience Institute, Singapore 308433, Singapore
    Neurochem Int 49:651-64. 2006
    ..In the mouse pilocarpine model of status epilepticus and subsequent temporal lobe epilepsy, spastin expression disappeared in hilar ..
  89. ncbi Assessment of the progressive nature of cell damage in the pilocarpine model of epilepsy
    L Covolan
    Departamento de Fisiologia, , , SP, Brasil
    Braz J Med Biol Res 39:915-24. 2006
    b>Pilocarpine-induced (320 mg/kg, i.p.) status epilepticus (SE) in adult (2-3 months) male Wistar rats results in extensive neuronal damage in limbic structures...
  90. ncbi Development of a rat pilocarpine model of seizure/status epilepticus that mimics chemical warfare nerve agent exposure
    Lauren M Tetz
    Department of Biochemical Pharmacology/Division of Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910-7500, USA
    Toxicol Ind Health 22:255-66. 2006
    We developed a rat pilocarpine seizure/status epilepticus (SE) model, which closely resembles 1.6-2...
  91. ncbi Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain
    Jens P Bankstahl
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Hannover, Germany
    Neuropharmacology 54:1006-16. 2008
    ..tissue of patients with intractable epilepsy and in rodent models of temporal lobe epilepsy, including the pilocarpine model. The mechanisms underlying the increase of Pgp after seizures are unclear...
  92. ncbi Glucose utilisation during status epilepticus in an epilepsy model induced by pilocarpine: a qualitative study
    Fulvio Alexandre Scorza
    Universidade de Mogi das Cruzes, Sao Paulo, Brazil
    Arq Neuropsiquiatr 60:198-203. 2002
    ..of this study was to determine which changes occur in the seizure anatomic substrates during the SE induced by pilocarpine (PILO) using [14C]-2 deoxyglucose functional mapping technique...
  93. ncbi Downregulation of the alpha5 subunit of the GABA(A) receptor in the pilocarpine model of temporal lobe epilepsy
    Carolyn R Houser
    Research Service, VA Greater Los Angeles Healthcare System, West Los Angeles, California, USA
    Hippocampus 13:633-45. 2003
    ..In chronic pilocarpine-treated rats displaying recurrent seizures, alpha5 subunit-labeling was substantially decreased in CA1 and ..
  94. ncbi New insights from the use of pilocarpine and kainate models
    J P Leite
    Department of Neurology, University of São Paulo School of Medicine at Ribeirão Preto, Campus Universitario, Ribeirao Preto, Brazil
    Epilepsy Res 50:93-103. 2002
    Local or systemic administration of pilocarpine and kainate in rodents leads to a pattern of repetitive limbic seizures and status epilepticus, which can last for several hours...
  95. ncbi Neuroprotective activity of antazoline against neuronal damage induced by limbic status epilepticus
    D Milhaud
    CNRS UPR 2580, Laboratoire de Génomique Fonctionnelle 141 rue de la Cardonille, F 34094 Montpellier 5, France
    Neuroscience 120:475-84. 2003
    ..Status epilepticus was induced by injecting pilocarpine (200 nmol) directly into the right pyriform cortex of male adult rats...
  96. ncbi Long-lasting modification of intrinsic discharge properties in subicular neurons following status epilepticus
    Jörg Wellmer
    Department of Epileptology, University of Bonn Medical Center, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur J Neurosci 16:259-66. 2002
    ..Here we have investigated whether SE, induced in rats with pilocarpine and terminated after 40 min with diazepam, persistently modifies the intrinsic excitability of pyramidal ..
  97. ncbi Epilepsy after early-life seizures can be independent of hippocampal injury
    Yogendra Sinh H Raol
    Division of Neurology, Pediatric Regional Epilepsy Program, Children s Hospital of Philadelphia, PA 19104, USA
    Ann Neurol 53:503-11. 2003
    ..early-life insults that lead to epilepsy result in similar structural changes, we subjected rat pups to lithium-pilocarpine-induced status epilepticus during postnatal development (day 20) and examined them as adults for the occurrence ..
  98. ncbi The contribution of the lateral posterior and anteroventral thalamic nuclei on spontaneous recurrent seizures in the pilocarpine model of epilepsy
    Fulvio Alexandre Scorza
    Universidade de Mogi das Cruzes, Universidade Federal de SP, Brazil
    Arq Neuropsiquiatr 60:572-5. 2002
    The pilocarpine model of epilepsy in rats is characterised by the occurrence of spontaneous seizures (SRSs) during the chronic period that recur 2-3 times per week during the whole animal life...
  99. ncbi Pilocarpine-induced epileptogenesis in the rat: impact of initial duration of status epilepticus on electrophysiological and neuropathological alterations
    Henrik Klitgaard
    Preclinical CNS Research, UCB SA Pharma Sector, Chemin du Foriest, B 1420 Braine l Alleud, Belgium
    Epilepsy Res 51:93-107. 2002
    This study characterized the electrophysiological and neuropathological changes in rat brains caused by pilocarpine (PILO)-induced status epilepticus (SE) of different duration. SE induced by PILO (375 mg/kg, i.p. adm...
  100. ncbi Down-regulation of mGluR8 in pilocarpine epileptic rats
    T Kral
    Departments of Neurosurgery and Epileptology, University Clinic, Bonn, Germany
    Synapse 47:278-84. 2003
    ..this study we analyzed the function of presynaptic mGluR8 on terminals of the lateral perforant pathway in the pilocarpine model of limbic epilepsy...
  101. ncbi Effect of topiramate following recurrent and prolonged seizures during early development
    Byung Ho Cha
    Clinical Neurophysiology Laboratory, Department of Neurology, Center for Research in Pediatric Epilepsy, Harvard Medical School, Children's Hospital Boston, Hunnewell 2, 300 Longwood Avenue, Boston, MA 02115, USA
    Epilepsy Res 51:217-32. 2002
    ..or saline for 4 weeks following a series of 25 neonatal seizures or status epilepticus (SE) induced by lithium-pilocarpine in postnatal day 20 rats...

Research Grants80

  1. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2007
    ..Aim 3: To test anticonvulsant action of two classes of compounds in controlling lithium/pilocarpine and OP paraoxon-induced status epilepticus...
  2. QUANTITATIVE GENETIC STUDY OF SEIZURES
    Thomas N Ferraro; Fiscal Year: 2010
    ..MEST QTLs are captured by testing them with chemoconvulsants pentylenetetrazol (PTZ), kainic acid (KA) and pilocarpine (PC). QTLs will be prioritized for further dissection based upon the results from all paradigms...
  3. PHARMACOTHERAPY FOR XEROSTOMIA IN SJOGREN'S SYNDROME
    SAMUEL HOPKINS; Fiscal Year: 2005
    ..including tear and saliva substitutes and centrally acting parasympathomimetic secretagogues such as pilocarpine and cevimeline, provide transient relief, but patients often find these remedies costly, ineffective, ..
  4. Neuroactive Steroid Therapy of Catamenial Epilepsy
    DOODIPALA REDDY; Fiscal Year: 2007
    ..We will critically test this hypothesis using a rat pilocarpine model of temporal lobe epilepsy with SRS...
  5. GABA-A Receptor Gene Transfer to Prevent Epileptogenesis
    SHELLEY RUSSEK; Fiscal Year: 2004
    ..Little is known, however, about the genetic mechanisms that regulate granule cells of adult rats following pilocarpine-induced status epilepticus (SE), it has yet to be demonstrated that these changes are either necessary or ..
  6. Efficacy of GluR5 Antogonists Against Soman-Induced Seizures and Neuropathology
    MARIA BRAGA; Fiscal Year: 2007
    ..have revealed that blockade of these receptors blocks epileptic seizures induced by the muscarinic agonist pilocarpine. As there are common mechanisms between pilocarpine-induced seizures and seizures induced by nerve agents, we ..
  7. Seizure-Induced Neurogenesis In The Dentate Gyrus
    CHARLES RIBAK; Fiscal Year: 2007
    ..structural changes occur in the hippocampal dentate granule cells of rodents after chemical (kainate or pilocarpine) or electrical (perforant path stimulation) induction of status epilepticus (SE)...
  8. REGULATION OF GLANDULAR MUCOUS CELL SECRETION
    DAVID CULP; Fiscal Year: 2001
    ..Current treatment for hyposalivation includes the systemic application of a muscarinic cholinergic agonist, pilocarpine, to directly stimulate remaining functional salivary secretory cells...
  9. EFFECTS OF LITHIUM ON CHOLINERGIC ACTIVITY
    RICHARD JOPE; Fiscal Year: 1990
    ..3) Lithium potentiates the in vivo response of the CNS to the muscarinic agonist, pilocarpine, as seen by the seizures generated by these two drugs...
  10. Aberrant Neurogenesis in Experimental Temporal Lobe Epilepsy
    Jack Parent; Fiscal Year: 2009
    ..Using the rat pilocarpine epilepsy model, we recently discovered that only developing, and not mature, DGCs are responsible for abnormal ..
  11. Aberrant Neurogenesis in Experimental Temporal Lobe Epilepsy
    Jack M Parent; Fiscal Year: 2010
    ..Using the rat pilocarpine epilepsy model, we recently discovered that only developing, and not mature, DGCs are responsible for abnormal ..
  12. NEUROPHYSIOLOGICAL STUDY OF CA1 SYNAPTIC REORGANIZATION
    JOSE CAVAZOS; Fiscal Year: 2003
    ..We evaluated the Pilocarpine model, and we determined that although CA1 synaptic reorganization occurs, it was not robust enough for the ..
  13. CHOLINERGIC MECHANISMS IN AGING AND AD
    LINCOLN POTTER; Fiscal Year: 2002
    ..use by itself or in right hemi-PD, but is expected to alter responses to apomorphine (dopamine agonist), pilocarpine and xanomeline (muscarinic agonists)...
  14. EFFECTS OF LITHIUM ON CHOLINERGIC ACTIVITY
    RICHARD JOPE; Fiscal Year: 1999
    ..Experiments involve EEG recordings of rats treated with lithium plus pilocarpine and dose-response studies with myo-inositol (icv and ip), comparisons with other inositol isomers, tests of the ..
  15. Canonical Transient Receptor Potential Channels and Excitotoxicity
    Fang Zheng; Fiscal Year: 2010
    ..To determine whether TRPC channels contribute to seizure and excitotoxicity in vivo, the well-established pilocarpine- induced limbic seizure model will be used...
  16. Canonical Transient Receptor Potential Channels and Excitotoxicity
    Fang Zheng; Fiscal Year: 2009
    ..To determine whether TRPC channels contribute to seizure and excitotoxicity in vivo, the well-established pilocarpine- induced limbic seizure model will be used...
  17. A NEW CHLORIDE SWEAT TEST FOR CYSTIC FIBROSIS SCREENING
    WARREN WARWICK; Fiscal Year: 2004
    ..stimulation method and collection cycle time will be optimized by comparing three new methods of transporting pilocarpine to the sweat glands and comparing the results to the current iontophoresis method...
  18. Counter Measures Against Acetylcholine Receptor Activated Status Epilepticus
    Robert DeLorenzo; Fiscal Year: 2007
    ..The research proposed in this study will use the rodent pilocarpine model of SE that has been shown to produce SE in an essentially identical manner to nerve agents as an animal ..
  19. Prostanoid modulators that reduce brain injury and inflammation after seizures
    Raymond Dingledine; Fiscal Year: 2007
    ..Prolonged status epilepticus (SE) induced by the muscarinic agonist, pilocarpine, triggers a similar series of molecular and cellular events in the rodent brain...
  20. Muscarinic regulation of plasticity in the brain
    Gene Robinson; Fiscal Year: 2009
    ..is based on the surprising, but robust, demonstration that treatment of caged bees with a muscarinic agonist, pilocarpine, results in brain plasticity identical to that produced by a week of real foraging experience. We will: 1...
  21. Muscarinic regulation of plasticity in the brain
    Gene Robinson; Fiscal Year: 2007
    ..is based on the surprising, but robust, demonstration that treatment of caged bees with a muscarinic agonist, pilocarpine, results in brain plasticity identical to that produced by a week of real foraging experience. We will: 1...