pilocarpine

Summary

Summary: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.

Top Publications

  1. doi Expression profile of microRNAs in rat hippocampus following lithium-pilocarpine-induced status epilepticus
    Kai Hu
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China
    Neurosci Lett 488:252-7. 2011
  2. ncbi Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California 94305 5330, USA
    J Neurosci 22:6650-8. 2002
  3. pmc Stereological analysis of GluR2-immunoreactive hilar neurons in the pilocarpine model of temporal lobe epilepsy: correlation of cell loss with mossy fiber sprouting
    Yiqun Jiao
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813, Durham, North Carolina 27710, USA
    Exp Neurol 205:569-82. 2007
  4. pmc Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    J Neurosci 29:8259-69. 2009
  5. ncbi Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions
    Alok K Sharma
    Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA
    Toxicol Pathol 35:984-99. 2007
  6. ncbi Pilocarpine-induced status epilepticus results in mossy fiber sprouting and spontaneous seizures in C57BL/6 and CD-1 mice
    Heather Shibley
    Department of Cell and Molecular Biology, Division of Neurobiology, Tulane University, 6400 Freret Street, New Orleans, LA 70118, USA
    Epilepsy Res 49:109-20. 2002
  7. doi Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice
    Christine J Müller
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Bunteweg 17, D 30559 Hannover, Germany
    Exp Neurol 219:284-97. 2009
  8. doi A muscarinic cholinergic mechanism underlies activation of the central pattern generator for locust flight
    Edgar Buhl
    University of Leipzig, Institute of Biology II, Talstr 33, 04103 Leipzig, Germany
    J Exp Biol 211:2346-57. 2008
  9. ncbi The pilocarpine model of epilepsy: what have we learned?
    Fulvio A Scorza
    Disciplina de Neurologia Experimental, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Rua Botucatu, 862, Edifício José Leal Prado, 04023 900 São Paulo, SP, Brasil
    An Acad Bras Cienc 81:345-65. 2009
  10. ncbi Investigation of oxidative stress involvement in hippocampus in epilepsy model induced by pilocarpine
    R M Freitas
    Laboratory of Physiology and Pharmacology, Federal University of Piaui, Piaui, Brazil
    Neurosci Lett 462:225-9. 2009

Research Grants

  1. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2009
  2. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2006
  3. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2010
  4. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2007
  5. PG-INDUCED REDUCTION OF INTRAOCULAR PRESSURE
    Carl Camras; Fiscal Year: 1990
  6. PG-INDUCED REDUCTION OF INTRAOCULAR PRESSURE
    Carl Camras; Fiscal Year: 1993
  7. QUANTITATIVE GENETIC STUDY OF SEIZURES
    Thomas N Ferraro; Fiscal Year: 2010
  8. QUANTITATIVE GENETIC STUDY OF SEIZURES
    THOMAS FERRARO; Fiscal Year: 2009
  9. QUANTITATIVE GENETIC STUDY OF SEIZURES
    Thomas N Ferraro; Fiscal Year: 2012
  10. Mechanisms of comorbidity between epilepsy and depression
    Andrey M Mazarati; Fiscal Year: 2011

Detail Information

Publications281 found, 100 shown here

  1. doi Expression profile of microRNAs in rat hippocampus following lithium-pilocarpine-induced status epilepticus
    Kai Hu
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China
    Neurosci Lett 488:252-7. 2011
    ....
  2. ncbi Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California 94305 5330, USA
    J Neurosci 22:6650-8. 2002
    ..sprouted mossy fibers at the EM level, and identified postsynaptic targets with GABA immunocytochemistry in the pilocarpine model of temporal lobe epilepsy. Granule cells projected an average of 1.0 and 1...
  3. pmc Stereological analysis of GluR2-immunoreactive hilar neurons in the pilocarpine model of temporal lobe epilepsy: correlation of cell loss with mossy fiber sprouting
    Yiqun Jiao
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813, Durham, North Carolina 27710, USA
    Exp Neurol 205:569-82. 2007
    ..Prolonged pilocarpine-induced status epilepticus killed 95% of these cells...
  4. pmc Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    J Neurosci 29:8259-69. 2009
    ..infused into the dorsal hippocampus for prolonged periods beginning within hours after rats sustained pilocarpine-induced status epilepticus...
  5. ncbi Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions
    Alok K Sharma
    Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA
    Toxicol Pathol 35:984-99. 2007
    ..Among post-status epilepticus models, induction of systemic kainic acid or pilocarpine-induced epilepsy is less labor-intensive than electrical-stimulation models and these models mirror the ..
  6. ncbi Pilocarpine-induced status epilepticus results in mossy fiber sprouting and spontaneous seizures in C57BL/6 and CD-1 mice
    Heather Shibley
    Department of Cell and Molecular Biology, Division of Neurobiology, Tulane University, 6400 Freret Street, New Orleans, LA 70118, USA
    Epilepsy Res 49:109-20. 2002
    ..and correlative axon sprouting in the dentate gyrus of CD-1 and C57BL/6 mice after systemic injection of pilocarpine. Pilocarpine induced seizures and status epilepticus (SE) after systemic injection in both strains, although SE ..
  7. doi Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice
    Christine J Müller
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Bunteweg 17, D 30559 Hannover, Germany
    Exp Neurol 219:284-97. 2009
    ..Animal models of epilepsy, such as the pilocarpine model of acquired temporal lobe epilepsy (TLE), are useful to study the relationship between epilepsy and ..
  8. doi A muscarinic cholinergic mechanism underlies activation of the central pattern generator for locust flight
    Edgar Buhl
    University of Leipzig, Institute of Biology II, Talstr 33, 04103 Leipzig, Germany
    J Exp Biol 211:2346-57. 2008
    ..In deafferented locusts, fictive flight was initiated by bath application of the muscarinic agonist pilocarpine, the acetylcholine analogue carbachol, and the acetylcholinesterase blocker eserine, but not by nicotine...
  9. ncbi The pilocarpine model of epilepsy: what have we learned?
    Fulvio A Scorza
    Disciplina de Neurologia Experimental, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Rua Botucatu, 862, Edifício José Leal Prado, 04023 900 São Paulo, SP, Brasil
    An Acad Bras Cienc 81:345-65. 2009
    The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioral and electrographic changes that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a ..
  10. ncbi Investigation of oxidative stress involvement in hippocampus in epilepsy model induced by pilocarpine
    R M Freitas
    Laboratory of Physiology and Pharmacology, Federal University of Piaui, Piaui, Brazil
    Neurosci Lett 462:225-9. 2009
    ..Using the epilepsy model obtained by systemic administration of pilocarpine in rats, we investigated the lipid peroxidation, nitrite content, superoxide dismutase (SOD) and catalase ..
  11. ncbi IMPA1 is essential for embryonic development and lithium-like pilocarpine sensitivity
    Kim Cryns
    Research and Early Development Europe, Johnson and Johnson Pharmaceutical Research and Development, Beerse, Belgium
    Neuropsychopharmacology 33:674-84. 2008
    ..activity in both the open-field test and the forced-swim test as well as a strongly increased sensitivity to pilocarpine-induced seizures, the latter supporting the idea that IMPA1 represents a physiologically relevant target for ..
  12. doi A gelatin-g-poly(N-isopropylacrylamide) biodegradable in situ gelling delivery system for the intracameral administration of pilocarpine
    Jui Yang Lai
    Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan 33302, Republic of China
    Biomaterials 33:2372-87. 2012
    ..95%) were achieved for GN vehicles, which was attributed to initial fast temperature triggered capture of pilocarpine and subsequent progressive degradation of gelatin network...
  13. pmc P2X7 receptor regulates leukocyte infiltrations in rat frontoparietal cortex following status epilepticus
    Ji Eun Kim
    Department of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chunchon 200 702, South Korea
    J Neuroinflammation 7:65. 2010
    ..In the present study, we investigated the roles of P2X7 receptor in recruitment and infiltration of neutrophil during epileptogenesis in rat epilepsy models...
  14. ncbi Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy
    Teresa Ravizza
    Department of Neuroscience, Laboratory of Experimental Neurology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Neurobiol Dis 29:142-60. 2008
    ..These data show that specific inflammatory pathways are chronically activated during epileptogenesis and they persist in chronic epileptic tissue, suggesting they may contribute to the etiopathogenesis of TLE...
  15. pmc Whole transcriptome analysis of the hippocampus: toward a molecular portrait of epileptogenesis
    Oswaldo K Okamoto
    Disciplina de Neurologia Experimental, Departamento de Neurologia e Neurocirurgia, Universidade Federal de Sao Paulo
    BMC Genomics 11:230. 2010
    ....
  16. ncbi Pilocarpine-induced seizures cause selective time-dependent changes to adult-generated hippocampal dentate granule cells
    Cynthia Walter
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Neurosci 27:7541-52. 2007
    ..label granule cells born 8 weeks before (mature), 1 week before (immature), or 3 weeks after (newborn) pilocarpine-epileptogenesis. Neuronal morphology was examined 4 and 8 weeks after pilocarpine treatment...
  17. ncbi Subiculum network excitability is increased in a rodent model of temporal lobe epilepsy
    Philip de Guzman
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Hippocampus 16:843-60. 2006
    ..to study the subiculum--a limbic structure that gates the information flow from and to the hippocampus--in pilocarpine-treated epileptic rats. Comparative data were obtained from age-matched nonepileptic controls (NEC)...
  18. ncbi Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model
    Karin Borges
    Department of PharmacologyEmory University, Atlanta, GA 30322, USA
    Exp Neurol 182:21-34. 2003
    The rodent pilocarpine model of epilepsy exhibits hippocampal sclerosis and spontaneous seizures and thus resembles human temporal lobe epilepsy...
  19. ncbi Recurrent circuits in layer II of medial entorhinal cortex in a model of temporal lobe epilepsy
    Sanjay S Kumar
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    J Neurosci 27:1239-46. 2007
    ..reorganization and formation of recurrent, excitatory synapses among layer II stellate cells in epileptic pilocarpine-treated rats...
  20. pmc The CREB/CRE transcriptional pathway: protection against oxidative stress-mediated neuronal cell death
    Boyoung Lee
    Department of Neuroscience, Ohio State University, Columbus, 43210, USA
    J Neurochem 108:1251-65. 2009
    ..Using the pilocarpine-evoked repetitive seizure model, we detected a marked enhancement of cell death in A-CREB transgenic mice...
  21. pmc Pilocarpine-induced temporal lobe epilepsy in the rat is associated with increased dopamine neuron activity
    Pierangelo Cifelli
    Departments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Int J Neuropsychopharmacol 15:957-64. 2012
    ..of temporal lobe seizures, we investigated whether an animal model of TLE using intrahippocampal injection of pilocarpine induces alterations in mesolimbic dopamine neuron activity...
  22. pmc P2X7 receptor activation ameliorates CA3 neuronal damage via a tumor necrosis factor-α-mediated pathway in the rat hippocampus following status epilepticus
    Ji Eun Kim
    Department of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chunchon, Kangwon Do 200 702, South Korea
    J Neuroinflammation 8:62. 2011
    ..In the present study, we addressed the question of whether P2X7 receptor-mediated TNF-α regulation is involved in pathogenesis and outcome of status epilepticus (SE)...
  23. ncbi Comparison of status epilepticus models induced by pilocarpine and nerve agents - a systematic review of the underlying aetiology and adopted therapeutic approaches
    F R Tang
    Temasek Laboratories, National University of Singapore, Singapore
    Curr Med Chem 18:886-99. 2011
    ..and metabolic, biochemical, neuroinflammatory changes and current therapeutic approaches reported in pilocarpine, soman, and sarin models of seizures...
  24. doi Network dynamics during development of pharmacologically induced epileptic seizures in rats in vivo
    Adi Cymerblit-Sabba
    Department of Physiology, Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel
    J Neurosci 30:1619-30. 2010
    ..The preictal state preceding pilocarpine-, kainate-, and picrotoxin-induced seizures was characterized by biphasic network dynamics composed of an early ..
  25. pmc High ratio of synaptic excitation to synaptic inhibition in hilar ectopic granule cells of pilocarpine-treated rats
    Ren Zhi Zhan
    Dept of Pharmacology and Cancer Biology, Box 3813, Duke Univ Medical Center, Durham, NC 27710, USA
    J Neurophysiol 104:3293-304. 2010
    ..This study used hippocampal slices prepared from rats that had experienced pilocarpine-induced status epilepticus to test the hypothesis that an imbalance of synaptic excitation and inhibition ..
  26. ncbi A 5-month period of epilepsy impairs spatial memory, decreases anxiety, but spares object recognition in the lithium-pilocarpine model in adult rats
    Julien Detour
    INSERM U398, Faculty of Medicine, Strasbourg, France
    Epilepsia 46:499-508. 2005
    In temporal lobe epilepsy (TLE), interictal behavioral disorders affect patients' quality of life. Therefore we studied long-term behavioral impairments in the lithium-pilocarpine (li-pilo) model of TLE.
  27. pmc Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic rats
    Mauro S Oliveira
    Departamento de Fisiologia e Farmacologia, Centro de Ciencias da Saude, Universidade Federal de Santa Maria, RS, Brazil
    Brain Res 1348:187-99. 2010
    ..In this study, we investigate the expression and function of SK channels in the pilocarpine model of mesial temporal lobe epilepsy...
  28. ncbi The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy
    Nadine Polascheck
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany
    Exp Neurol 224:219-33. 2010
    ..pro-drug of the highly potent and selective COX-2 inhibitor valdecoxib, alters the long-term consequences of a pilocarpine-induced SE in rats. Parecoxib was administered twice daily at 10 mg/kg for 18 days following SE...
  29. pmc Mossy fibers are the primary source of afferent input to ectopic granule cells that are born after pilocarpine-induced seizures
    Joseph P Pierce
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, NY 10021, USA
    Exp Neurol 196:316-31. 2005
    ..EGC dendrites were examined in tissue from epileptic rats that had initially been treated with pilocarpine to induce status epilepticus and subsequently had spontaneous seizures...
  30. doi Oxidative stress in rat hippocampus caused by pilocarpine-induced seizures is reversed by buspirone
    Rizângela Lyne Mendes de Freitas
    Course of Pharmacy of Catholic Faculty Rainha do Sertão, Quixada, Ceara, CE, Brazil
    Brain Res Bull 81:505-9. 2010
    ..buspirone effects on oxidative stress in rat hippocampus after seizures and status epilepticus (SE) induced by pilocarpine. In pilocarpine group there was a significant increase in lipid peroxidation and nitrite levels...
  31. pmc Stereological methods reveal the robust size and stability of ectopic hilar granule cells after pilocarpine-induced status epilepticus in the adult rat
    Daniel P McCloskey
    Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, Route 9W, West Haverstraw, NY 10993, USA
    Eur J Neurosci 24:2203-10. 2006
    ..total number of ectopic hilar granule cells was estimated using unbiased stereology at different times after pilocarpine-induced status epilepticus...
  32. doi The duration of sustained convulsive seizures determines the pattern of hippocampal neurogenesis and the development of spontaneous epilepsy in rats
    Yu Wen Hung
    Institute of Physiology, National Yang Ming University, Taipei, Taiwan
    Epilepsy Res 98:206-15. 2012
    ..Sprague-Dawley rats with pilocarpine-induced convulsive SS were divided into short SS (30 min) and long SS (2 h) groups...
  33. doi mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice
    Jian Xin Liu
    Epilepsy Research Laboratory, National Neuroscience Institute, Singapore, Singapore
    Epilepsy Res 82:111-23. 2008
    ..PKCbeta2 or PKCgamma expression at the border between the stratum oriens and alveus (O/A border) at 2h during pilocarpine induced status epilepticus (SE), and in the stratum pyramidale in CA1 area at 1 day after pilocarpine induced ..
  34. pmc Morphologic integration of hilar ectopic granule cells into dentate gyrus circuitry in the pilocarpine model of temporal lobe epilepsy
    Michael C Cameron
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Comp Neurol 519:2175-92. 2011
    After pilocarpine-induced status epilepticus, many granule cells born into the postseizure environment migrate aberrantly into the dentate hilus...
  35. ncbi Changes in vesicular transporters for gamma-aminobutyric acid and glutamate reveal vulnerability and reorganization of hippocampal neurons following pilocarpine-induced seizures
    Jean Luc Boulland
    The Biotechnology Centre of Oslo, University of Oslo, Oslo, N 0349 Norway
    J Comp Neurol 503:466-85. 2007
    ..GABA)-ergic hippocampal networks as well as the time course of these reorganizations during development of pilocarpine-induced temporal lobe epilepsy were studied with in situ hybridization and immunohistochemistry experiments for ..
  36. doi The neuroprotective effect of curcumin and Nigella sativa oil against oxidative stress in the pilocarpine model of epilepsy: a comparison with valproate
    Heba S Aboul Ezz
    Laboratory of Neurophysiology, Zoology Department, Faculty of Science, Cairo University, Giza, Egypt
    Neurochem Res 36:2195-204. 2011
    Oxidative stress has been implicated to play a role in epileptogenesis and pilocarpine-induced seizures...
  37. doi Seizure susceptibility and the brain regional sensitivity to oxidative stress in male and female rats in the lithium-pilocarpine model of temporal lobe epilepsy
    Sandra Peternel
    Department of Pharmacology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia
    Prog Neuropsychopharmacol Biol Psychiatry 33:456-62. 2009
    ..of different brain regions to oxidative stress in rats with status epilepticus (SE) induced by lithium-pilocarpine administration, that provides a common experimental model of temporal lobe epilepsy (TLE) in humans...
  38. ncbi Antioxidant response and oxidative damage in brain cortex after high dose of pilocarpine
    S Tejada
    Laboratori de Neurofisiologia, Departament de Biologia Fonamental i Ciencies de la Salut, Universitat de les Illes Balears, Crta Valldemossa, km 7 5, E 07122 Palma de Mallorca, Balears, Spain
    Brain Res Bull 71:372-5. 2007
    b>Pilocarpine is a cholinergic agonist capable to induce seizures and an epilepticus-like state in rodents...
  39. pmc Microglial ablation and lipopolysaccharide preconditioning affects pilocarpine-induced seizures in mice
    Martine M Mirrione
    Department of Pharmacological Sciences, Molecular and Cellular Pharmacology, Stony Brook University, Stony Brook, NY 11794 8651, USA
    Neurobiol Dis 39:85-97. 2010
    ..To explore this, we examined the effects of pilocarpine-induced seizures in transgenic mice where microglia/macrophages were conditionally ablated...
  40. ncbi Ketogenic diet exhibits neuroprotective effects in hippocampus but fails to prevent epileptogenesis in the lithium-pilocarpine model of mesial temporal lobe epilepsy in adult rats
    Benjamin Linard
    INSERM U666, Université de Strasbourg Strasbourg, France
    Epilepsia 51:1829-36. 2010
    ..Our goal was to assess the neuroprotective or antiepileptogenic effect of these diets in a well-characterized model of mesial temporal lobe epilepsy following initial SE induced by lithium-pilocarpine in adult rats.
  41. ncbi Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures
    E R Garrido Sanabria
    Department of Biological Sciences, University of Texas at Brownsville Texas Southmost College, 80 Fort Brown, Brownsville, TX 78520, USA
    Neuroscience 142:871-83. 2006
    ..b>Pilocarpine-induced status epilepticus (SE) was chosen as a model to generate chronic epileptic animals...
  42. doi The effects of alpha-tocopherol on hippocampal oxidative stress prior to in pilocarpine-induced seizures
    A R Tome
    State University of Ceara, Campus do Itaperi, Fortaleza, Ceara, Brazil
    Neurochem Res 35:580-7. 2010
    ..It has been suggested that pilocarpine-induced seizures is mediated by an increase in oxidative stress...
  43. ncbi Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy
    Brigitte Voutsinos-Porche
    INSERM U405, Faculty of Medicine, Strasbourg, France
    Neurobiol Dis 17:385-402. 2004
    ..NF-kappaB), and Cyclooxygenase-2 (COX-2) expression together with neurodegeneration in the rat lithium-pilocarpine model...
  44. ncbi Strain differences affect the induction of status epilepticus and seizure-induced morphological changes
    B Xu
    Department of Psychology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1
    Eur J Neurosci 20:403-18. 2004
    ..We conclude that genetic factors clearly affect seizure development and related morphological changes in both standard laboratory strains and the selectively bred seizure-prone and seizure-resistant strains...
  45. pmc Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy
    Andrey M Mazarati
    Department of Pediatrics, Neurology Division, David Geffen School of Medicine, University of California Los Angeles, Box 951752, 22 474 MDCC, Los Angeles, CA 90095 1752, USA
    Neurobiol Dis 34:457-61. 2009
    ..We suggest that the observed hyperactivity of the HPA axis may underlie co-morbidity between epilepsy and depression...
  46. ncbi The role of muscarinic acetylcholine receptor-mediated activation of extracellular signal-regulated kinase 1/2 in pilocarpine-induced seizures
    Jennifer L Berkeley
    Department of Neurology, Center for Neurodegenerative Disease, Emory University, Whitehead Biomedical Research Building, 615 Michael Street, Atlanta, GA 30322, USA
    J Neurochem 82:192-201. 2002
    b>Pilocarpine-induced seizures are mediated by the M(1) subtype of muscarinic acetylcholine receptor (mAChR), but little is known about the signaling mechanisms linking the receptor to seizures...
  47. ncbi Effect of changing from concomitant timolol pilocarpine to bimatoprost monotherapy on ocular blood flow and IOP in primary chronic angle closure glaucoma
    Harish C Agarwal
    Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    J Ocul Pharmacol Ther 19:105-12. 2003
    ..pressure (IOP) in eyes of primary chronic angle closure glaucoma patients already on concomitant timolol and pilocarpine. Thirty two patients of bilateral primary chronic angle closure glaucoma (PCACG) on topical timolol 0...
  48. ncbi Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy
    A R Brooks-Kayal
    Joseph Stokes Research Institute of The Children s Hospital of Philadelphia, Department of Neurology, University of Pennsylvania, 19104, USA
    Nat Med 4:1166-72. 1998
    ....
  49. ncbi Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy
    Masayuki Kobayashi
    Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California 94305 5342, USA
    J Neurosci 23:2440-52. 2003
    ..We report the loss of GABAergic inhibition of granule cells in the temporal dentate gyrus of pilocarpine-induced epileptic rats...
  50. ncbi Increased persistent sodium currents in rat entorhinal cortex layer V neurons in a post-status epilepticus model of temporal lobe epilepsy
    Newton Agrawal
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    Epilepsia 44:1601-4. 2003
    ..In this study, we investigated whether status epilepticus caused changes in the function of voltage-gated sodium channels in entorhinal cortex layer V neurons, a cellular group important for the genesis of limbic seizures...
  51. doi Loss of GABAergic neurons in the subiculum and its functional implications in temporal lobe epilepsy
    Andreas Knopp
    Dept of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Brain 131:1516-27. 2008
    ..Using the pilocarpine-model of temporal lobe epilepsy (TLE), the present study examines the vulnerability of GABAergic subicular ..
  52. ncbi Status epilepticus in immature rats leads to behavioural and cognitive impairment and epileptogenesis
    Hana Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Vídeòská 1083, Prague 4, CZ 142 20, Czech Republic
    Eur J Neurosci 19:3255-65. 2004
    ..The present study examined whether SE induced by LiCl-pilocarpine in normal immature brain (at the age of 12 or 25 days; P12 or P25) causes cognitive decline and epileptogenesis,..
  53. doi Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy
    Claudia Brandt
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, D 30559 Hannover, Germany
    J Neurosci 30:8602-12. 2010
    ..study, it was evaluated whether prolonged administration of the selective NKCC1 inhibitor, bumetanide, after a pilocarpine-induced SE modifies the development of epilepsy in adult female rats...
  54. pmc Comorbidity between epilepsy and depression: experimental evidence for the involvement of serotonergic, glucocorticoid, and neuroinflammatory mechanisms
    Eduardo Pineda
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1752, USA
    Epilepsia 51:110-4. 2010
    ..We established that animals that had been subjected to lithium chloride and pilocarpine status epilepticus (SE) and developed spontaneous recurrent seizures, exhibited a set of impairments congruent ..
  55. doi An increase in persistent sodium current contributes to intrinsic neuronal bursting after status epilepticus
    Shmuel Chen
    Department of Medical Neurobiology, Hebrew University Hadassah School of Medicine, P O Box 12272, Jerusalem 91121, Israel
    J Neurophysiol 105:117-29. 2011
    ..In the widely used pilocarpine-status epilepticus (SE) rat model of temporal lobe epilepsy (TLE), a major alteration is the marked increase in ..
  56. doi Long-term expressional changes of Na+ -K+ -Cl- co-transporter 1 (NKCC1) and K+ -Cl- co-transporter 2 (KCC2) in CA1 region of hippocampus following lithium-pilocarpine induced status epilepticus (PISE)
    Xiubin Li
    Neurological Department of the 1st Affiliated Hospital of Sun Yat sen University, Guangzhou, 510080, PR China
    Brain Res 1221:141-6. 2008
    ..to investigate the long-term expression profiles of NKCC1 and KCC2 in CA1 region in the mice model of lithium-pilocarpine induced status epilepticus (PISE) and their relationship with epileptogenesis...
  57. doi Enhanced proliferation of acinar and progenitor cells by prophylactic pilocarpine treatment underlies the observed amelioration of radiation injury to parotid glands
    Fred R Burlage
    Department of Radiation Oncology, University Medical Center Groningen, The Netherlands
    Radiother Oncol 90:253-6. 2009
    Administration of pilocarpine before irradiation can ameliorate radiation-induced hyposalivation. Indirect evidence suggests that this effect may be mediated through induction of a compensatory response...
  58. ncbi Proteome changes associated with hippocampal MRI abnormalities in the lithium pilocarpine-induced model of convulsive status epilepticus
    Nicholas D E Greene
    Neural Development Unit, UCL Institute of Child Health, University College London, London, UK
    Proteomics 7:1336-44. 2007
    ..The lithium pilocarpine model of status epilepticus (SE) in the rat provides a model in which to investigate the molecular and ..
  59. doi Effects of repeated electroconvulsive shock seizures and pilocarpine-induced status epilepticus on emotional behavior in the rat
    Armando Cardoso
    Faculty of Medicine of Porto, Institute of Anatomy, Alameda Prof Hernani Monteiro, Porto, Portugal
    Epilepsy Behav 14:293-9. 2009
    ..shock (ECS) and compared them with those resulting from prolonged status epilepticus (SE) induced with pilocarpine. Using the open-field and elevated plus-maze tests, we detected the presence of behavioral alterations ..
  60. pmc Altered expression and localization of hippocampal A-type potassium channel subunits in the pilocarpine-induced model of temporal lobe epilepsy
    M M Monaghan
    Neuroscience, Wyeth Discovery Research, CN8000, Princeton, NJ 08543, USA
    Neuroscience 156:550-62. 2008
    ..In rats, systemic administration of pilocarpine induces a model of human temporal lobe epilepsy, wherein a brief period of status epilepticus (SE) triggers ..
  61. pmc Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to dopamine deficits
    Donnie Eddins
    Dept of Psychiatry and Behavioral Sciences, Duke University Medical Ctr, Durham, NC 27710, USA
    Neurotoxicol Teratol 32:99-108. 2010
    ..acetylcholine receptors to developmental CPF-mediated effects, the effects of developmental nicotine and pilocarpine exposure throughout the first five days after fertilization were determined...
  62. ncbi Loss of interneurons innervating pyramidal cell dendrites and axon initial segments in the CA1 region of the hippocampus following pilocarpine-induced seizures
    Celine Dinocourt
    INMED, INSERM U29, Parc Scientifique de Luminy, B P 13 13273 Marseille, France
    J Comp Neurol 459:407-25. 2003
    In the pilocarpine model of chronic limbic seizures, vulnerability of GABAergic interneurons to excitotoxic damage has been reported in the hippocampal CA1 region...
  63. ncbi Molecular and functional changes in voltage-dependent Na(+) channels following pilocarpine-induced status epilepticus in rat dentate granule cells
    R K Ellerkmann
    Department of Epileptology, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neuroscience 119:323-33. 2003
    ..In the present study, we examined whether an episode of S.E. induced by pilocarpine in vivo alters functional properties and expression of voltage-gated Na(+) channels in dentate granule cells (..
  64. ncbi Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus
    Keun Hwa Jung
    Neural Stem Cell Laboratory in Clinical Research Institute, Stem Cell Research Center, Department of Neurology, Seoul National University Hospital, Program in Neuroscience, Neuroscience Research Institute of SNUMRC, Seoul, South Korea
    Neurobiol Dis 23:237-46. 2006
    ..Celecoxib attenuated the likelihood of developing spontaneous recurrent seizures after pilocarpine-induced prolonged seizure...
  65. doi Pilocarpine-induced status epilepticus increases Homer1a and changes mGluR5 expression
    C F Cavarsan
    Department of Physiology, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
    Epilepsy Res 101:253-60. 2012
    ..In the present work, we investigated whether pilocarpine-induced status epilepticus (SE) would alter Homer1a and mGluR5 expression in hippocampus...
  66. ncbi Decreased glutamate receptor binding and NMDA R1 gene expression in hippocampus of pilocarpine-induced epileptic rats: neuroprotective role of Bacopa monnieri extract
    Reas Khan
    Molecular Neurobiology and Cell Biology Unit, Centre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology, Cochin 682 022, Kerala, India
    Epilepsy Behav 12:54-60. 2008
    ..In association with pilocarpine-induced epilepsy, there was significant downregulation of NMDA R1 gene expression and glutamate receptor ..
  67. ncbi Local cerebral blood flow during lithium-pilocarpine seizures in the developing and adult rat: role of coupling between blood flow and metabolism in the genesis of neuronal damage
    Anne Pereira de Vasconcelos
    Faculty of Medicine, Institut National de la Sante et de la Recherche Medicale, Strasbourg, France
    J Cereb Blood Flow Metab 22:196-205. 2002
    ..Lithium-pilocarpine-induced status epilepticus is associated with extended damage in adult rats, mostly in the forebrain limbic ..
  68. doi Reactive oxygen species generated by NADPH oxidase are involved in neurodegeneration in the pilocarpine model of temporal lobe epilepsy
    Rafaela R F Pestana
    Department of Physiology and Biophysics, University of Sao Paulo, Sao Paulo, SP 05508 900, Brazil
    Neurosci Lett 484:187-91. 2010
    ..stress could have a role in the hippocampal neurodegeneration observed in temporal lobe epilepsy induced by pilocarpine. We first determined the spatio-temporal pattern of ROS generation, by means of detection with dihydroethidium ..
  69. doi Microinjection of GABAergic agents into the anterior nucleus of the thalamus modulates pilocarpine-induced seizures and status epilepticus
    Simone Bittencourt
    Department of Physiology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Seizure 19:242-6. 2010
    ..We investigate whether microinjections of GABAergic agonists into the AN were protective against pilocarpine-induced generalized seizures and status epilepticus (SE)...
  70. pmc Cyclooxygenase-2 inhibitor inhibits hippocampal synaptic reorganization in pilocarpine-induced status epilepticus rats
    Hai Ju Zhang
    Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan 430060, China
    J Zhejiang Univ Sci B 9:903-15. 2008
    To examine modulations caused by cyclooxygenase-2 (COX-2) inhibitors on altered microenvironments and overbalanced neurotransmitters in pilocarpine-induced epileptic status rats and to investigate possible mechanisms.
  71. ncbi Remodeling dendritic spines in the rat pilocarpine model of temporal lobe epilepsy
    M Isokawa
    Brain Research Institute, Center for Health Sciences, University of California, Los Angeles 90024 1761, USA
    Neurosci Lett 258:73-6. 1998
    ..However, little is known when and how the degeneration occurs. In the present study of the rat pilocarpine model, visualization of dendrites of the hippocampal dentate granule cells (DGCs) by biocytin revealed a ..
  72. ncbi Increased partitioning of pilocarpine to the oily phase of submicron emulsion does not result in improved ocular bioavailability
    M Sznitowska
    Department of Pharmaceutical Technology, Medical University of Gdansk, ul Hallera 107, 80 416, Gdansk, Poland
    Int J Pharm 202:161-4. 2000
    Submicron emulsions containing pilocarpine as ion-pair with mono-dodecylphosphoric acid were prepared. Physical stability of these preparations was confirmed during 4 months of storage at 4 degrees C...
  73. ncbi Lovastatin reduces neuronal cell death in hippocampal CA1 subfield after pilocarpine-induced status epilepticus: preliminary results
    Pauline Rangel
    Laboratorio de Neurociencias, Núcleo de Pesquisas Tecnológicas, Universidade de Mogi das Cruzes, Mogi das Cruzes, SP, Brazil
    Arq Neuropsiquiatr 63:972-6. 2005
    To further characterize the capacity of lovastatin to prevent hippocampal neuronal loss after pilocarpine-induced status epilepticus (SE) METHOD: Adult male Wistar rats were divided into four groups: (A) control rats, received neither ..
  74. ncbi Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent
    Christian Frisch
    Department of Epileptology, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Epilepsy Res 73:173-80. 2007
    ..TPM) dose-dependently protects hippocampal CA1 and CA3 neurons during initial status epilepticus in the rat pilocarpine model of temporal lobe epilepsy by inhibition of mitochondrial transition pore opening...
  75. ncbi Physical training reverts hippocampal electrophysiological changes in rats submitted to the pilocarpine model of epilepsy
    Ricardo Mario Arida
    Laboratorio de Neurologia Experimental, Universidade Federal de Sao Paulo Escola Paulista de Medicina UNIFESP EPM, Rua Botucatu 862, Vila Clementino, CEP 04023 900 Sao Paulo, Brazil
    Physiol Behav 83:165-71. 2004
    ..of aerobic exercise on "in vitro" hippocampal electrophysiological parameters observed in rats submitted to the pilocarpine model of epilepsy...
  76. ncbi Different effects of neuroprotectants FK-506 and cyclosporin A on susceptibility to pilocarpine-induced seizures in rats with brain injured at different developmental stages
    Zuzanna Setkowicz
    Department of Neuroanatomy, Institute of Zoology, Jagiellonian University, 6 Ingardena St, Krakow 30060, Poland
    Epilepsy Res 61:63-72. 2004
    ..On postnatal day 60, all the animals received single i.p. pilocarpine injections to evoke epileptic seizures...
  77. ncbi Signaling pathways involved in pilocarpine-induced mucin secretion in rat submandibular glands
    Lucila Busch
    Pharmacology Unit, School of Dentistry, University of Buenos Aires, Marcelo T de Alvear 2142 C1122AAH, Buenos Aires, Argentina
    Life Sci 80:842-51. 2007
    We have studied the signaling pathways involved in pilocarpine-induced mucin release in rat submandibular slices. Pilocarpine produced a significant increment of PGE2 levels and a positive (r=0.8870) and significant (p=0...
  78. ncbi Laserinterferometric assessment of pilocarpine-induced movement of an accommodating intraocular lens: a randomized trial
    Oliver Findl
    Department of Ophthalmology, University of Vienna, Austria
    Ophthalmology 111:1515-21. 2004
    To measure the axial movement of an accommodating intraocular lens (IOL) induced by ciliary muscle contraction after application of pilocarpine.
  79. ncbi Preferential neuron loss in the rat piriform cortex following pilocarpine-induced status epilepticus
    Shaoyun Chen
    Department of Anatomy, Toho University School of Medicine, Omori nishi 5 21 16, Ota ku, Tokyo 143 8540, Japan
    Epilepsy Res 74:1-18. 2007
    ..We used stereological methods to examine the specificity and extent of neuron loss in the PC of pilocarpine-treated rats...
  80. ncbi Effect of interictal spikes on single-cell firing patterns in the hippocampus
    Jun li Zhou
    Neuroscience Center at Dartmouth, Section of Neurology, Dartmouth Medical School, Lebanon, New Hampshire, USA
    Epilepsia 48:720-31. 2007
    ..The purpose of this study was to determine the effect of IS on single-cell firing patterns in freely moving rats with a prior history of seizures...
  81. ncbi Effects of fluoxetine and venlafaxine and pilocarpine on rat parotid glands
    Silvana da Silva
    Department of Stomatology, School of Dentistry, Pontifical Catholic University of Parana, Curitiba Parana, Brazil
    Med Chem 5:483-90. 2009
    ..volume (CV), of rat parotid salivary glands and salivary flow rate (SFR), as well as the secretagogue action of pilocarpine on this flow...
  82. ncbi Prolonged infusion of tetrodotoxin does not block mossy fiber sprouting in pilocarpine-treated rats
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, Palo Alto, California 94305 5342, USA
    Epilepsia 45:452-8. 2004
    ..The present study tested the hypothesis that prolonged, focal infusion of tetrodotoxin would block mossy fiber sprouting after an epileptogenic treatment...
  83. ncbi In vivo 1H magnetic resonance spectroscopy, T2-weighted and diffusion-weighted MRI during lithium-pilocarpine-induced status epilepticus in the rat
    Pieter van Eijsden
    Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Brain Res 1030:11-8. 2004
    ..In the rat lithium-pilocarpine model of SE, we performed quantified T(2)- and isotropic-diffusion-weighted (DW) magnetic resonance imaging (..
  84. ncbi Consequences of pilocarpine-induced recurrent seizures in neonatal rats
    Shi Xiu-Yu
    Department of Pediatrics, Qilu Hospital, Shandong University, No 107, Wen Hua Xi Road, Jinan, Shandong 250012, China
    Brain Dev 29:157-63. 2007
    ..For seizure induction, neonatal Wistar rats were intraperitoneally injected with pilocarpine on postnatal day 1 (P1), P4 and P7...
  85. ncbi The GABA uptake inhibitor beta-alanine reduces pilocarpine-induced tremor and increases extracellular GABA in substantia nigra pars reticulata as measured by microdialysis
    Keita Ishiwari
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    J Neurosci Methods 140:39-46. 2004
    ..related to tremor, the present study tested the GABA uptake blocker beta-alanine for its ability to reduce pilocarpine-induced tremulous jaw movements...
  86. doi Effects of ubiquinone on hydroperoxide concentration and antioxidant enzymatic activities in the rat hippocampus during pilocarpine-induced seizures
    Itala Mônica de Sales Santos
    Laboratory Experimental Research in Biological Sciences, Federal University of Piaui, Piaui, Brazil
    Brain Res 1315:33-40. 2010
    ..the neuroprotective effects of UQ in rats, against the observed oxidative stress during seizures induced by pilocarpine. Wistar rats were treated with either 0.9% saline (i.p., control group), UQ (5, 10 or 20 mg/kg, i.p...
  87. doi Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX
    Lyndsey E Collins
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Pharmacol Biochem Behav 94:561-9. 2010
    ..investigated the ability of adenosine antagonists to reverse the tremorogenic effect of the muscarinic agonist pilocarpine. While the adenosine A(2A) antagonist MSX-3 was incapable of reversing the tremulous jaw movements induced by ..
  88. ncbi Volumetric magnetic resonance imaging of functionally relevant structural alterations in chronic epilepsy after pilocarpine-induced status epilepticus in rats
    Heiko G Niessen
    Department of Neurology II, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Epilepsia 46:1021-6. 2005
    After pilocarpine-induced epilepsy in rats, volumetric magnetic resonance imaging (MRI) reveals significant morphologic changes in functionally relevant structures of the brain...
  89. ncbi Behavioral, biochemical and histological studies in a model of pilocarpine-induced spontaneous recurrent seizures
    Janusz Szyndler
    Department of Experimental and Clinical Pharmacology, Medical University, 26 28 Krakowskie Przedmiescie Street, 00 927 Warsaw, Poland
    Pharmacol Biochem Behav 81:15-23. 2005
    Although the presence of profound cognitive disturbances in lithium-pilocarpine-induced spontaneous recurrent seizures (SRS) has been well documented, much less is known about changes in emotional behavior, in this model of temporal lobe ..
  90. ncbi Facilitation of granule cell epileptiform activity by mossy fiber-released zinc in the pilocarpine model of temporal lobe epilepsy
    Olga Timofeeva
    Department of Pharmacology and Cancer Biology, Box 3813, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 1078:227-34. 2006
    ..Hippocampal slices from rats that had experienced pilocarpine-induced status epilepticus and developed a recurrent mossy fiber pathway were used to investigate this ..
  91. doi Electroencephalogram functional connectivity between rat hippocampus and cortex after pilocarpine treatment
    S Tejada
    Department of Biologia Fonamental i Ciències de la Salut, University of the Balearic Islands, IUNICS, Palma de Mallorca, Spain
    Neuroscience 165:621-31. 2010
    The muscarinic agonist pilocarpine has been shown to increase the duration and total number of episodes presenting theta rhythm-simultaneously in hippocampus and cortex-in rats during the waking states...
  92. pmc Effects of latrunculin B on outflow facility, intraocular pressure, corneal thickness, and miotic and accommodative responses to pilocarpine in monkeys
    Mehmet Okka
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin, USA
    Trans Am Ophthalmol Soc 102:251-7; discussion 257-9. 2004
    ..topical latrunculin B (LAT-B) will increase outflow facility and decrease intraocular pressure (IOP) without adversely affecting the cornea, and inhibit miotic and accommodative responses to pilocarpine, in ocular normotensive monkeys.
  93. doi Evidences for pharmacokinetic interaction of riluzole and topiramate with pilocarpine in pilocarpine-induced seizures in rats
    Wojciech Zgrajka
    Department of Toxicology, Institute of Agricultural Medicine, Lublin, Poland
    Epilepsy Res 88:269-74. 2010
    In this study we investigated the effectiveness of two antiepileptic drugs: riluzole and topiramate against pilocarpine-induced seizures, which are considered to be a model of intractable epilepsy commonly used to investigate the ..
  94. ncbi Pyrrolidine dithiocarbamate protects the piriform cortex in the pilocarpine status epilepticus model
    Jonna Soerensen
    Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilians University, Munich, Germany
    Epilepsy Res 87:177-83. 2009
    ..epilepticus-associated cell loss in the hippocampus and piriform cortex was evaluated in the rat fractionated pilocarpine model...
  95. ncbi Pilocarpine and other cholinergic drugs in the management of salivary gland dysfunction
    M M Ferguson
    Department of Oral Medicine and Oral Surgery, University of Otago, New Zealand
    Oral Surg Oral Med Oral Pathol 75:186-91. 1993
    ..Of the pharmacologic agents available, pilocarpine has been used extensively over the last century...
  96. doi Astroglial loss and edema formation in the rat piriform cortex and hippocampus following pilocarpine-induced status epilepticus
    Ji Eun Kim
    Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chunchon, Kangwon Do 200 702, South Korea
    J Comp Neurol 518:4612-28. 2010
    ..study we analyzed aquaporin-4 (AQP4) immunoreactivity in the piriform cortex (PC) and the hippocampus of pilocarpine-induced rat epilepsy model to elucidate the roles of AQP4 in brain edema following status epilepticus (SE)...
  97. doi CCR3, CCR2A and macrophage inflammatory protein (MIP)-1a, monocyte chemotactic protein-1 (MCP-1) in the mouse hippocampus during and after pilocarpine-induced status epilepticus (PISE)
    J H Xu
    Epilepsy Research Lab, National Neuroscience Institute, Singapore
    Neuropathol Appl Neurobiol 35:496-514. 2009
    ..protein 1-alpha (MIP-1alpha), monocyte chemotactic protein-1 (MCP-1) in the normal mouse central nervous system (CNS) and in the hippocampus at different time points during and after pilocarpine-induced status epilepticus (PISE).
  98. doi Vesicular acetylcholine transporter knock-down mice are more susceptible to pilocarpine induced status epilepticus
    Patrícia A M Guidine
    Nucleo de Neurociencias, Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Avenida Antonio Carlos 6627, CEP 31270 901 Campus Pampulha, Belo Horizonte, MG, Brazil
    Neurosci Lett 436:201-4. 2008
    The pilocarpine (PILO) animal model of Temporal Lobe Epilepsy (TLE) portrays the most common changes in hippocampal circuitry found in human TLE...
  99. pmc Network hyperexcitability within the deep layers of the pilocarpine-treated rat entorhinal cortex
    Philip de Guzman
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, QC H3A 2B4, Canada
    J Physiol 586:1867-83. 2008
    ..50 +/- 0.62 s) in the entorhinal cortex (EC) of brain slices obtained from pilocarpine-treated rats but not in those from age-matched, nonepileptic control (NEC) animals...
  100. ncbi Effects of benzodiazepine and pilocarpine on rat parotid glands: histomorphometric and sialometric study
    M V Zaclikevis
    Department of Stomatology, School of Dentistry, Pontificia Universidade Catolica do Parana, Rua Imaculada Conceição 1155, Prado Velho 80215 901, Curitiba Parana, Brazil
    Med Chem 5:74-8. 2009
    Benzodiazepines are among the most frequently prescribed drugs and are often related with dry mouth. Pilocarpine is a cholinergic agonist that increases salivary flow rate and has been used to treat xerostomia...
  101. doi Mu-calpain mediates hippocampal neuron death in rats after lithium-pilocarpine-induced status epilepticus
    Shuhua Wang
    Department of Neurology, Qilu Hospital, Medical School of Shandong University, Jinan 250012, China
    Brain Res Bull 76:90-6. 2008
    ..In the current study, rats were induced SE by lithium-pilocarpine administration. Our data showed hippocampal neurons death appeared at 6h after SE and sustained for 7 days...

Research Grants84

  1. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2009
    ..Aim 3: To test anticonvulsant action of two classes of compounds in controlling lithium/pilocarpine and OP paraoxon-induced status epilepticus...
  2. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2006
    ..Aim 3: To test anticonvulsant action of two classes of compounds in controlling lithium/pilocarpine and OP paraoxon-induced status epilepticus...
  3. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2010
    ..Aim 3: To test anticonvulsant action of two classes of compounds in controlling lithium/pilocarpine and OP paraoxon-induced status epilepticus...
  4. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2007
    ..Aim 3: To test anticonvulsant action of two classes of compounds in controlling lithium/pilocarpine and OP paraoxon-induced status epilepticus...
  5. PG-INDUCED REDUCTION OF INTRAOCULAR PRESSURE
    Carl Camras; Fiscal Year: 1990
    ..The effects of cyclo- oxygenase inhibitors (COIs) on the IOP response after epinephrine, timolol, pilocarpine phospholine iodide, arachidonic acid, PGF2 alpha, forskolin, vanadate, corynanthine, pergolide, salbutamol, and ..
  6. PG-INDUCED REDUCTION OF INTRAOCULAR PRESSURE
    Carl Camras; Fiscal Year: 1993
    ..The effects of cyclo- oxygenase inhibitors (COIs) on the IOP response after epinephrine, timolol, pilocarpine phospholine iodide, arachidonic acid, PGF2 alpha, forskolin, vanadate, corynanthine, pergolide, salbutamol, and ..
  7. QUANTITATIVE GENETIC STUDY OF SEIZURES
    Thomas N Ferraro; Fiscal Year: 2010
    ..MEST QTLs are captured by testing them with chemoconvulsants pentylenetetrazol (PTZ), kainic acid (KA) and pilocarpine (PC). QTLs will be prioritized for further dissection based upon the results from all paradigms...
  8. QUANTITATIVE GENETIC STUDY OF SEIZURES
    THOMAS FERRARO; Fiscal Year: 2009
    ..MEST QTLs are captured by testing them with chemoconvulsants pentylenetetrazol (PTZ), kainic acid (KA) and pilocarpine (PC). QTLs will be prioritized for further dissection based upon the results from all paradigms...
  9. QUANTITATIVE GENETIC STUDY OF SEIZURES
    Thomas N Ferraro; Fiscal Year: 2012
    ..MEST QTLs are captured by testing them with chemoconvulsants pentylenetetrazol (PTZ), kainic acid (KA) and pilocarpine (PC). QTLs will be prioritized for further dissection based upon the results from all paradigms...
  10. Mechanisms of comorbidity between epilepsy and depression
    Andrey M Mazarati; Fiscal Year: 2011
    ..We will employ a model of chronic epilepsy that develops in male Wistar rats following pilocarpine - induced status epilepticus (SE)...
  11. PHARMACOTHERAPY FOR XEROSTOMIA IN SJOGREN'S SYNDROME
    SAMUEL HOPKINS; Fiscal Year: 2005
    ..including tear and saliva substitutes and centrally acting parasympathomimetic secretagogues such as pilocarpine and cevimeline, provide transient relief, but patients often find these remedies costly, ineffective, ..
  12. Perisomatic Inhibitory Network Dysfunction in Neurological Disease
    Vijayalakshmi Santhakumar; Fiscal Year: 2011
    ..The study will use pilocarpine induced status epilepticus to model development of acquired epilepsy, and a combination of anatomical, ..
  13. Neuroactive Steroid Therapy of Catamenial Epilepsy
    DOODIPALA REDDY; Fiscal Year: 2006
    ..We will critically test this hypothesis using a rat pilocarpine model of temporal lobe epilepsy with SRS...
  14. Neurobiological basis of Depression as a Comorbidity in Epilepsy
    Andrey M Mazarati; Fiscal Year: 2010
    ..To induce TLE, two weeks-old Wistar rats will be subjected to LiCl and pilocarpine status epilepticus (SE)...
  15. Neuroactive Steroid Therapy of Catamenial Epilepsy
    DOODIPALA REDDY; Fiscal Year: 2007
    ..We will critically test this hypothesis using a rat pilocarpine model of temporal lobe epilepsy with SRS...
  16. Neuroactive Steroid Therapy of Catamenial Epilepsy
    DOODIPALA REDDY; Fiscal Year: 2007
    ..We will critically test this hypothesis using a rat pilocarpine model of temporal lobe epilepsy with SRS...
  17. Neurobiological basis of Depression as a Comorbidity in Epilepsy
    Andrey Mazarati; Fiscal Year: 2009
    ..To induce TLE, two weeks-old Wistar rats will be subjected to LiCl and pilocarpine status epilepticus (SE)...
  18. GABA-A Receptor Gene Transfer to Prevent Epileptogenesis
    SHELLEY RUSSEK; Fiscal Year: 2003
    ..Little is known, however, about the genetic mechanisms that regulate granule cells of adult rats following pilocarpine-induced status epilepticus (SE), it has yet to be demonstrated that these changes are either necessary or ..
  19. GABA-A Receptor Gene Transfer to Prevent Epileptogenesis
    SHELLEY RUSSEK; Fiscal Year: 2004
    ..Little is known, however, about the genetic mechanisms that regulate granule cells of adult rats following pilocarpine-induced status epilepticus (SE), it has yet to be demonstrated that these changes are either necessary or ..
  20. GABA-A Receptor Gene Transfer to Prevent Epileptogenesis
    SHELLEY RUSSEK; Fiscal Year: 2002
    ..Little is known, however, about the genetic mechanisms that regulate granule cells of adult rats following pilocarpine-induced status epilepticus (SE), it has yet to be demonstrated that these changes are either necessary or ..
  21. Efficacy of GluR5 Antogonists Against Soman-Induced Seizures and Neuropathology
    MARIA BRAGA; Fiscal Year: 2006
    ..have revealed that blockade of these receptors blocks epileptic seizures induced by the muscarinic agonist pilocarpine. As there are common mechanisms between pilocarpine-induced seizures and seizures induced by nerve agents, we ..
  22. Efficacy of GluR5 Antogonists Against Soman-Induced Seizures and Neuropathology
    MARIA BRAGA; Fiscal Year: 2009
    ..have revealed that blockade of these receptors blocks epileptic seizures induced by the muscarinic agonist pilocarpine. As there are common mechanisms between pilocarpine-induced seizures and seizures induced by nerve agents, we ..
  23. Efficacy of GluR5 Antogonists Against Soman-Induced Seizures and Neuropathology
    MARIA BRAGA; Fiscal Year: 2007
    ..have revealed that blockade of these receptors blocks epileptic seizures induced by the muscarinic agonist pilocarpine. As there are common mechanisms between pilocarpine-induced seizures and seizures induced by nerve agents, we ..
  24. A MUSCARINIC HYPOTHESIS FOR AFFECTIVE ILLNESS
    JOHN GILLIN; Fiscal Year: 1990
    ..If funded, we will extend our previous studies with the Cholinergic REM Induction Test (CRIT) by using pilocarpine instead of arecoline...
  25. Seizure-Induced Neurogenesis In The Dentate Gyrus
    CHARLES RIBAK; Fiscal Year: 2005
    ..structural changes occur in the hippocampal dentate granule cells of rodents after chemical (kainate or pilocarpine) or electrical (perforant path stimulation) induction of status epilepticus (SE)...
  26. Seizure-Induced Neurogenesis In The Dentate Gyrus
    CHARLES RIBAK; Fiscal Year: 2007
    ..structural changes occur in the hippocampal dentate granule cells of rodents after chemical (kainate or pilocarpine) or electrical (perforant path stimulation) induction of status epilepticus (SE)...
  27. Seizure-Induced Neurpgenesis In The Dentate Gyrus
    CHARLES RIBAK; Fiscal Year: 2006
    ..structural changes occur in the hippocampal dentate granule cells of rodents after chemical (kainate or pilocarpine) or electrical (perforant path stimulation) induction of status epilepticus (SE)...
  28. REGULATION OF GLANDULAR MUCOUS CELL SECRETION
    DAVID CULP; Fiscal Year: 2000
    ..Current treatment for hyposalivation includes the systemic application of a muscarinic cholinergic agonist, pilocarpine, to directly stimulate remaining functional salivary secretory cells...
  29. REGULATION OF GLANDULAR MUCOUS CELL SECRETION
    DAVID CULP; Fiscal Year: 2001
    ..Current treatment for hyposalivation includes the systemic application of a muscarinic cholinergic agonist, pilocarpine, to directly stimulate remaining functional salivary secretory cells...
  30. REGULATION OF GLANDULAR MUCOUS CELL SECRETION
    DAVID CULP; Fiscal Year: 1999
    ..Current treatment for hyposalivation includes the systemic application of a muscarinic cholinergic agonist, pilocarpine, to directly stimulate remaining functional salivary secretory cells...
  31. Treatment of Status Epilepticus: A Translational Proposal
    Claude Wasterlain; Fiscal Year: 2009
    ..We will induce SE chemically with lithium and pilocarpine, or electrically by stimulating the perforant path, and will treat at 3 time points: after the second intense ..
  32. BDNF and JAK/STAT: partners in seizure-induced GABA-A receptor downregulation
    REBECCA STURTEVANT BENHAM; Fiscal Year: 2010
    ..with the JAK/STAT complex, as well as the potential role of JAK/STAT activation to epileptogenesis in the pilocarpine TLE model...
  33. Neuronal Loss and Plasticity in Epilepsy
    Carolyn R Houser; Fiscal Year: 2011
    ..chloride transporters will be altered in ways that could reduce the effectivenss of GABAergic inhibition in the pilocarpine-treated animals and thus contribute to the development of epilepsy and the initiation of spontaneous seizures...
  34. MINORITY BIOMEDICAL SUPPORT
    Harriet Williams; Fiscal Year: 1980
    ..under fed, fasted, and pilocarpine stimulated conditions...
  35. Rational polytherapy in the treatment of cholinergic seizures
    Claude G Wasterlain; Fiscal Year: 2012
    ..combinations can, with little depression of consciousness, stop seizures induced by high-dose lithium and pilocarpine and refractory to a profoundly anesthetic dose of benzodiazepine, the best 2- and 3-drug combinations in a ..
  36. Anticonvulsant effects of novel concentric ring electrode electrical stimulation
    WALTER GRANT BESIO; Fiscal Year: 2010
    ..Hypothesis 2: {The suppression of pilocarpine (PILO)-induced status epilepticus (SE) by TcES via concentric ring electrodes reduces SE-provoked neuronal ..
  37. Anticonvulsant effects of novel concentric ring electrode electrical stimulation
    Walter Besio; Fiscal Year: 2009
    ..Hypothesis 2: {The suppression of pilocarpine (PILO)-induced status epilepticus (SE) by TcES via concentric ring electrodes reduces SE-provoked neuronal ..
  38. EFFECTS OF LITHIUM ON CHOLINERGIC ACTIVITY
    RICHARD JOPE; Fiscal Year: 1990
    ..3) Lithium potentiates the in vivo response of the CNS to the muscarinic agonist, pilocarpine, as seen by the seizures generated by these two drugs...
  39. Aberrant Neurogenesis in Experimental Temporal Lobe Epilepsy
    Jack M Parent; Fiscal Year: 2012
    ..Using the rat pilocarpine epilepsy model, we recently discovered that only developing, and not mature, DGCs are responsible for abnormal ..
  40. ENDOGENOUS DYNORPHIN OPIOIDS AND TEMPORAL LOBE EPILEPSY
    Charles Chavkin; Fiscal Year: 1999
    ..b>Pilocarpine-treatment provides an animal model of temporal lobe epilepsy that duplicates many features of human pathology ..
  41. Rat transcriptome biomarkers for the prediction of temporal lobe epilepsy
    STANISLAV KARSTEN; Fiscal Year: 2009
    ..Male and female Wistar and Sprague-Dawley rats will be subjected to SE induced by either systemic pilocarpine or intrahippocampal kainic acid during either childhood (postnatal day 35) or adulthood (postnatal day 90)...
  42. Aberrant Neurogenesis in Experimental Temporal Lobe Epilepsy
    Jack M Parent; Fiscal Year: 2010
    ..Using the rat pilocarpine epilepsy model, we recently discovered that only developing, and not mature, DGCs are responsible for abnormal ..
  43. Aberrant Neurogenesis in Experimental Temporal Lobe Epilepsy
    Jack Parent; Fiscal Year: 2009
    ..Using the rat pilocarpine epilepsy model, we recently discovered that only developing, and not mature, DGCs are responsible for abnormal ..
  44. ZINC AND GABAA RECEPTOR PLASTICITY
    Istvan Mody; Fiscal Year: 2000
    ..The general hypothesis is that kindling and pilocarpine-induced epilepsy are associated with critical subunit-specific plastic changes of synaptic GABA/A receptors in ..
  45. ZINC AND GABAA RECEPTOR PLASTICITY
    Istvan Mody; Fiscal Year: 2001
    ..The general hypothesis is that kindling and pilocarpine-induced epilepsy are associated with critical subunit-specific plastic changes of synaptic GABA/A receptors in ..
  46. ZINC AND GABAA RECEPTOR PLASTICITY
    Istvan Mody; Fiscal Year: 1999
    ..The general hypothesis is that kindling and pilocarpine-induced epilepsy are associated with critical subunit-specific plastic changes of synaptic GABA/A receptors in ..
  47. ZINC AND GABAA RECEPTOR PLASTICITY
    Istvan Mody; Fiscal Year: 2002
    ..The general hypothesis is that kindling and pilocarpine-induced epilepsy are associated with critical subunit-specific plastic changes of synaptic GABA/A receptors in ..
  48. NEUROPHYSIOLOGICAL STUDY OF CA1 SYNAPTIC REORGANIZATION
    JOSE CAVAZOS; Fiscal Year: 2002
    ..We evaluated the Pilocarpine model, and we determined that although CA1 synaptic reorganization occurs, it was not robust enough for the ..
  49. NEUROPHYSIOLOGICAL STUDY OF CA1 SYNAPTIC REORGANIZATION
    JOSE CAVAZOS; Fiscal Year: 2003
    ..We evaluated the Pilocarpine model, and we determined that although CA1 synaptic reorganization occurs, it was not robust enough for the ..
  50. TRANSCORNEAL FLUX ENHANCEMENT OF PILOCARPINE
    DAVID KROHN; Fiscal Year: 1980
    This proposal is to investigate kinetics of transcorneal flux and intra-ocular fate of pilocarpine. Methodology and mechanism of flux enhancement is of prime import...
  51. CHOLINERGIC MECHANISMS IN AGING AND AD
    LINCOLN POTTER; Fiscal Year: 2000
    ..use by itself or in right hemi-PD, but is expected to alter responses to apomorphine (dopamine agonist), pilocarpine and xanomeline (muscarinic agonists)...
  52. CHOLINERGIC MECHANISMS IN AGING AND AD
    LINCOLN POTTER; Fiscal Year: 2001
    ..use by itself or in right hemi-PD, but is expected to alter responses to apomorphine (dopamine agonist), pilocarpine and xanomeline (muscarinic agonists)...
  53. EFFECTS OF LITHIUM ON CHOLINERGIC ACTIVITY
    RICHARD JOPE; Fiscal Year: 1999
    ..Experiments involve EEG recordings of rats treated with lithium plus pilocarpine and dose-response studies with myo-inositol (icv and ip), comparisons with other inositol isomers, tests of the ..
  54. CHOLINERGIC MECHANISMS IN AGING AND AD
    LINCOLN POTTER; Fiscal Year: 2002
    ..use by itself or in right hemi-PD, but is expected to alter responses to apomorphine (dopamine agonist), pilocarpine and xanomeline (muscarinic agonists)...
  55. Subunit dependent properties of kainate receptors
    DAVID MOTT; Fiscal Year: 2009
    ..course of changes in KAR subunit RNA and protein in the hippocampus during the development of epilepsy after pilocarpine-induced status epilepticus (SE)...
  56. Canonical Transient Receptor Potential Channels and Excitotoxicity
    Fang Zheng; Fiscal Year: 2010
    ..To determine whether TRPC channels contribute to seizure and excitotoxicity in vivo, the well-established pilocarpine- induced limbic seizure model will be used...
  57. Counter Measures Against Acetylcholine Receptor Activated Status Epilepticus
    Robert DeLorenzo; Fiscal Year: 2007
    ..The research proposed in this study will use the rodent pilocarpine model of SE that has been shown to produce SE in an essentially identical manner to nerve agents as an animal ..
  58. ANTERIOR CHAMBER FLUID ACETYLCHOLINE CONCENTRATION
    Jonathan Wirtschafter; Fiscal Year: 1980
    ..endogenous ACh concentration in the aqueous humor is of the same order of magnitude as the average therapeutic pilocarpine concentration achieved in the anterior chamber with topical application...
  59. Canonical Transient Receptor Potential Channels and Excitotoxicity
    Fang Zheng; Fiscal Year: 2009
    ..To determine whether TRPC channels contribute to seizure and excitotoxicity in vivo, the well-established pilocarpine- induced limbic seizure model will be used...
  60. A NEW CHLORIDE SWEAT TEST FOR CYSTIC FIBROSIS SCREENING
    WARREN WARWICK; Fiscal Year: 2003
    ..stimulation method and collection cycle time will be optimized by comparing three new methods of transporting pilocarpine to the sweat glands and comparing the results to the current iontophoresis method...
  61. A NEW CHLORIDE SWEAT TEST FOR CYSTIC FIBROSIS SCREENING
    WARREN WARWICK; Fiscal Year: 2004
    ..stimulation method and collection cycle time will be optimized by comparing three new methods of transporting pilocarpine to the sweat glands and comparing the results to the current iontophoresis method...
  62. Counter Measures Against Acetylcholine Receptor Activated Status Epilepticus
    ROBERT JOHN DELORENZO; Fiscal Year: 2010
    ..The research proposed in this study will use the rodent pilocarpine model of SE that has been shown to produce SE in an essentially identical manner to nerve agents as an animal ..
  63. Counter Measures Against Acetylcholine Receptor Activated Status Epilepticus
    Robert DeLorenzo; Fiscal Year: 2006
    ..The research proposed in this study will use the rodent pilocarpine model of SE that has been shown to produce SE in an essentially identical manner to nerve agents as an animal ..
  64. Counter Measures Against Acetylcholine Receptor Activated Status Epilepticus
    Robert DeLorenzo; Fiscal Year: 2009
    ..The research proposed in this study will use the rodent pilocarpine model of SE that has been shown to produce SE in an essentially identical manner to nerve agents as an animal ..
  65. Prostanoid modulators that reduce brain injury and inflammation after seizures
    Raymond Dingledine; Fiscal Year: 2007
    ..Prolonged status epilepticus (SE) induced by the muscarinic agonist, pilocarpine, triggers a similar series of molecular and cellular events in the rodent brain...
  66. EVALUATION OF ESTERASE ACTIVITY AND PRODRUGS IN THE EYE
    Vincent Lee; Fiscal Year: 1990
    ..changes of 0-1'- methylcyclopropanoyl timolol upon co-administration with other glaucoma drugs such as pilocarpine, epinephrine, and their prodrugs, or with other ocular drugs such as phenylephrine and proparacaine...
  67. Prostanoid modulators that reduce brain injury and inflammation after seizures
    Raymond Dingledine; Fiscal Year: 2006
    ..Prolonged status epilepticus (SE) induced by the muscarinic agonist, pilocarpine, triggers a similar series of molecular and cellular events in the rodent brain...
  68. Prostanoid modulators that reduce brain injury and inflammation after seizures
    Raymond Dingledine; Fiscal Year: 2009
    ..Prolonged status epilepticus (SE) induced by the muscarinic agonist, pilocarpine, triggers a similar series of molecular and cellular events in the rodent brain...
  69. EVALUATION OF ESTERASE ACTIVITY AND PRODRUGS IN THE EYE
    Vincent Lee; Fiscal Year: 1993
    ..changes of 0-1'- methylcyclopropanoyl timolol upon co-administration with other glaucoma drugs such as pilocarpine, epinephrine, and their prodrugs, or with other ocular drugs such as phenylephrine and proparacaine...
  70. Muscarinic regulation of plasticity in the brain
    Gene Robinson; Fiscal Year: 2006
    ..is based on the surprising, but robust, demonstration that treatment of caged bees with a muscarinic agonist, pilocarpine, results in brain plasticity identical to that produced by a week of real foraging experience. We will: 1...
  71. Muscarinic regulation of plasticity in the brain
    Gene Robinson; Fiscal Year: 2009
    ..is based on the surprising, but robust, demonstration that treatment of caged bees with a muscarinic agonist, pilocarpine, results in brain plasticity identical to that produced by a week of real foraging experience. We will: 1...
  72. Muscarinic regulation of plasticity in the brain
    Gene Robinson; Fiscal Year: 2007
    ..is based on the surprising, but robust, demonstration that treatment of caged bees with a muscarinic agonist, pilocarpine, results in brain plasticity identical to that produced by a week of real foraging experience. We will: 1...
  73. Adenosine Receptors and Restoration of Salivary Gland in Sjogren's Syndrome
    Umesh S Deshmukh; Fiscal Year: 2012
    ..of SS will be treated with AR agonists and restoration of salivary gland function monitored by measuring pilocarpine induced salivation...
  74. LITHIUM POTENTIATED STATUS EPILEPTICUS
    RICHARD JOPE; Fiscal Year: 1990
    ..The basic model entails treatment with LiCl (3 mEq/kg; ip) and pilocarpine (30 mg/kg; sc) which invariably produces generalized convulsive status epilepticus which lasts for several ..
  75. ADRENERGIC & CHOLINERGIC MECHANISMS IN GLAUCOMA THERAPY
    JON POLANSKY; Fiscal Year: 1993
    ..considerable interest in the mechanisms by which adrenergic (eg, epinephrine and timolol) and cholinergic (eg, pilocarpine, carbachol, echothiophate iodide) drugs reduce IOP, as well as to understand the effects of new alpha ..
  76. ADRENERGIC & CHOLINERGIC MECHANISMS IN GLAUCOMA THERAPY
    JON POLANSKY; Fiscal Year: 1990
    ..considerable interest in the mechanisms by which adrenergic (eg, epinephrine and timolol) and cholinergic (eg, pilocarpine, carbachol, echothiophate iodide) drugs reduce IOP, as well as to understand the effects of new alpha ..