alkaloids

Summary

Summary: Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)

Top Publications

  1. ncbi Sanguinarine-dependent induction of apoptosis in primary effusion lymphoma cells
    Azhar R Hussain
    Human Cancer Genomic Research, King Fahad National Center for Children s Cancer and Research, Biological and Medical Research, Riyadh 11211, Saudi Arabia
    Cancer Res 67:3888-97. 2007
  2. pmc Alkaloids in marine algae
    Kasim Cemal Güven
    Istanbul Aydin University, Inonu Cad, Istanbul, Turkey
    Mar Drugs 8:269-84. 2010
  3. pmc Neurotoxic alkaloids: saxitoxin and its analogs
    Maria Wiese
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia
    Mar Drugs 8:2185-211. 2010
  4. ncbi Evolution of secondary metabolites from an ecological and molecular phylogenetic perspective
    Michael Wink
    Universitat Heidelberg, Institut für Pharmazie und molekulare Biotechnologie, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
    Phytochemistry 64:3-19. 2003
  5. ncbi beta-Carboline alkaloids: biochemical and pharmacological functions
    Rihui Cao
    Guangdong Key Laboratory for Pharmaceutical Functional Genes and Center for Biopharmaceutical Research, School of Life Sciences, Sun Yat Sen University, 135 Xin Gang Xi Road, Guangzhou 510275, P R China
    Curr Med Chem 14:479-500. 2007
  6. ncbi Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids
    Berrin Ozcelik
    Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Gazi University, Ankara, Turkey
    Pharm Biol 49:396-402. 2011
  7. pmc Gene clusters for insecticidal loline alkaloids in the grass-endophytic fungus Neotyphodium uncinatum
    Martin J Spiering
    Department of Plant Pathology, University of Kentucky, Lexington, 40546 0312, USA
    Genetics 169:1403-14. 2005
  8. pmc Regulation of a chemical defense against herbivory produced by symbiotic fungi in grass plants
    Dong Xiu Zhang
    Department of Plant Pathology, University of Kentucky, Lexington, Kentucky 40146 0312, USA
    Plant Physiol 150:1072-82. 2009
  9. ncbi Consumption of bitter alkaloids in Drosophila melanogaster in multiple-choice test conditions
    Marie Jeanne Sellier
    Insitut National de la Recherche Agronomique, Département Santé des Plantes et Environnement, UMR 1272 Physiologie de l Insecte, Versailles, France
    Chem Senses 36:323-34. 2011
  10. ncbi Piperine inhibits TNF-alpha induced adhesion of neutrophils to endothelial monolayer through suppression of NF-kappaB and IkappaB kinase activation
    Sarvesh Kumar
    Molecular Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, Delhi, India
    Eur J Pharmacol 575:177-86. 2007

Detail Information

Publications380 found, 100 shown here

  1. ncbi Sanguinarine-dependent induction of apoptosis in primary effusion lymphoma cells
    Azhar R Hussain
    Human Cancer Genomic Research, King Fahad National Center for Children s Cancer and Research, Biological and Medical Research, Riyadh 11211, Saudi Arabia
    Cancer Res 67:3888-97. 2007
    ....
  2. pmc Alkaloids in marine algae
    Kasim Cemal Güven
    Istanbul Aydin University, Inonu Cad, Istanbul, Turkey
    Mar Drugs 8:269-84. 2010
    This paper presents the alkaloids found in green, brown and red marine algae...
  3. pmc Neurotoxic alkaloids: saxitoxin and its analogs
    Maria Wiese
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia
    Mar Drugs 8:2185-211. 2010
    Saxitoxin (STX) and its 57 analogs are a broad group of natural neurotoxic alkaloids, commonly known as the paralytic shellfish toxins (PSTs)...
  4. ncbi Evolution of secondary metabolites from an ecological and molecular phylogenetic perspective
    Michael Wink
    Universitat Heidelberg, Institut für Pharmazie und molekulare Biotechnologie, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
    Phytochemistry 64:3-19. 2003
    ..distribution of some major defence compounds that are typical for the respective plant families; quinolizidine alkaloids and non-protein amino acids for legumes; tropane and steroidal alkaloids for Solanaceae, and iridoids and ..
  5. ncbi beta-Carboline alkaloids: biochemical and pharmacological functions
    Rihui Cao
    Guangdong Key Laboratory for Pharmaceutical Functional Genes and Center for Biopharmaceutical Research, School of Life Sciences, Sun Yat Sen University, 135 Xin Gang Xi Road, Guangzhou 510275, P R China
    Curr Med Chem 14:479-500. 2007
    beta-Carboline alkaloids are a large group of natural and synthetic indole alkaloids with different degrees of aromaticity, some of which are widely distributed in nature, including various plants, foodstuffs, marine creatures, insects, ..
  6. ncbi Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids
    Berrin Ozcelik
    Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Gazi University, Ankara, Turkey
    Pharm Biol 49:396-402. 2011
    Some natural products consisting of the alkaloids yohimbine and vincamine (indole-type), scopolamine and atropine (tropane-type), colchicine (tropolone-type), allantoin (imidazolidine-type), trigonelline (pyridine-type) as well as ..
  7. pmc Gene clusters for insecticidal loline alkaloids in the grass-endophytic fungus Neotyphodium uncinatum
    Martin J Spiering
    Department of Plant Pathology, University of Kentucky, Lexington, 40546 0312, USA
    Genetics 169:1403-14. 2005
    Loline alkaloids are produced by mutualistic fungi symbiotic with grasses, and they protect the host plants from insects...
  8. pmc Regulation of a chemical defense against herbivory produced by symbiotic fungi in grass plants
    Dong Xiu Zhang
    Department of Plant Pathology, University of Kentucky, Lexington, Kentucky 40146 0312, USA
    Plant Physiol 150:1072-82. 2009
    ..endophytes) of meadow fescue (MF; Lolium pratense), which they protect from insects by producing loline alkaloids. High levels of lolines are produced following insect damage or mock herbivory (clipping)...
  9. ncbi Consumption of bitter alkaloids in Drosophila melanogaster in multiple-choice test conditions
    Marie Jeanne Sellier
    Insitut National de la Recherche Agronomique, Département Santé des Plantes et Environnement, UMR 1272 Physiologie de l Insecte, Versailles, France
    Chem Senses 36:323-34. 2011
    ..Thus, despite of the multiplicity of choices available, flies consistently avoid alkaloids mixed with a sugar solution, and their choices are strongly dependent on their taste system...
  10. ncbi Piperine inhibits TNF-alpha induced adhesion of neutrophils to endothelial monolayer through suppression of NF-kappaB and IkappaB kinase activation
    Sarvesh Kumar
    Molecular Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, Delhi, India
    Eur J Pharmacol 575:177-86. 2007
    ..These results suggest a possible mechanism of anti-inflammatory activity of piperine. Therefore, piperine or its structural analogues could be used for the development of new anti-inflammatory molecules...
  11. ncbi The basic helix-loop-helix transcription factor CrMYC2 controls the jasmonate-responsive expression of the ORCA genes that regulate alkaloid biosynthesis in Catharanthus roseus
    Hongtao Zhang
    Institute of Biology, Leiden University, Sylvius Laboratory, PO Box 9505, 2300 RA Leiden, The Netherlands
    Plant J 67:61-71. 2011
    ....
  12. ncbi The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01
    P R Graves
    Department of Cell Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 275:5600-5. 2000
    ..Taken together our results identify the Chk1 kinase and the Cdc25C pathway as potential targets of G(2) checkpoint abrogation by UCN-01...
  13. ncbi Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids
    Hyun Ah Jung
    Division of Food Science and Biotechnology, Pukyong National University, Busan, South Korea
    Biol Pharm Bull 32:1433-8. 2009
    Coptidis Rhizoma and its isolated alkaloids are reported to possess a variety of activities, including neuroprotective and antioxidant effects...
  14. pmc Aniquinazolines A-D, four new quinazolinone alkaloids from marine-derived endophytic fungus Aspergillus nidulans
    Chun Yan An
    Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
    Mar Drugs 11:2682-94. 2013
    Four new quinazolinone alkaloids, namely, aniquinazolines A-D (1-4), were isolated and identified from the culture of Aspergillus nidulans MA-143, an endophytic fungus obtained from the leaves of marine mangrove plant Rhizophora stylosa...
  15. ncbi Loline alkaloids: Currencies of mutualism
    Christopher L Schardl
    Department of Plant Pathology, 201F Plant Science Building, 1405 Veterans Drive, University of Kentucky, Lexington, KY 40546 0312, USA
    Phytochemistry 68:980-96. 2007
    ..Clavicipitaceae)--are known for production of antiherbivore metabolites such as the bioprotective loline alkaloids. Lolines are saturated pyrrolizidines with an exo-1-amine and an ether bridge between C-2 and C-7...
  16. ncbi Tissue-specific metabolite profiling of alkaloids in Sinomenii Caulis using laser microdissection and liquid chromatography-quadrupole/time of flight-mass spectrometry
    Ling Yi
    Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong, China
    J Chromatogr A 1248:93-103. 2012
    ..Results revealed that different tissues and cells contained varied alkaloids, among which six alkaloids, i.e...
  17. pmc A phase II trial of huperzine A in mild to moderate Alzheimer disease
    M S Rafii
    Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA, USA
    Neurology 76:1389-94. 2011
    ..Huperzine A is a natural cholinesterase inhibitor derived from the Chinese herb Huperzia serrata that may compare favorably in symptomatic efficacy to cholinesterase inhibitors currently in use for Alzheimer disease (AD)...
  18. ncbi Triazole and dihydroimidazole alkaloids from the marine sediment-derived fungus Penicillium paneum SD-44
    Chun Shun Li
    Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, People s Republic of China
    J Nat Prod 74:1331-4. 2011
    A novel triazole carboxylic acid, penipanoid A (1), two new quinazolinone alkaloids, penipanoids B (2) and C (3), and a very recently reported quinazolinone derivative (4) were isolated from the marine sediment-derived fungus Penicillium ..
  19. ncbi Antimalarial β-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate
    Hongbo Huang
    CAS Key Laboratory of Marine Bio resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Rd, Guangzhou 510301, People s Republic of China
    J Nat Prod 74:2122-7. 2011
    Four new β-carboline alkaloids, designated marinacarbolines A-D (1-4), two new indolactam alkaloids, 13-N-demethyl-methylpendolmycin (5) and methylpendolmycin-14-O-α-glucoside (6), and the three known compounds 1-acetyl-β-carboline (7)..
  20. ncbi Anxiolytic effects of erythrinian alkaloids from Erythrina mulungu
    Otavio Flausino
    Department of Psychobiology, FFCLRP, University of Sao Paulo, Avenida Bandeirantes, 3900, 14040 901 Ribeirao Preto, SP, Brazil
    J Nat Prod 70:48-53. 2007
    ..Furthermore, the anxiolytic effects of the E. mulungu aqueous alcoholic crude extract and of the purified alkaloids were evaluated using the elevated T-maze test.
  21. ncbi Aaptamine alkaloids from the Vietnamese sponge Aaptos sp
    Larisa K Shubina
    Laboratory of Chemistry MaNaPro, Pacific Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Vladivostok, Russia
    Nat Prod Commun 4:1085-8. 2009
    ..The isolated compounds showed a potential cancer preventive activity...
  22. ncbi Lepadins D-F: antiplasmodial and antitrypanosomal decahydroquinoline derivatives from the tropical marine tunicate Didemnum sp
    Anthony D Wright
    Institute for Pharmaceutical Biology, Technical University of Braunschweig, Mendelssohnstrasse 1, 38106 Braunschweig, Germany
    J Med Chem 45:3067-72. 2002
    From a new tunicate species, belonging to the genus Didemnum, three alkaloids possessing an unusual and extremely rare decahydroquinoline skeleton and showing significant and selective antiplasmodial and antitrypanosomal activity were ..
  23. pmc Bromopyrrole alkaloids as lead compounds against protozoan parasites
    Fernando Scala
    Dipartimento di Chimica delle Sostanze Naturali, Universita di Napoli Federico II, via D Montesano, 49, I 80131, Napoli, Italy
    Mar Drugs 8:2162-74. 2010
    In the present study, 13 bromopyrrole alkaloids, including the oroidin analogs hymenidin (2), dispacamide B (3) and dispacamide D (4), stevensine (5) and spongiacidin B (6), their derivatives lacking the imidazole ring bromoaldisin (7), ..
  24. ncbi Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice
    Zhi Fei Wang
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China
    Pharmacol Biochem Behav 83:603-11. 2006
    ..It also indicates that the MAPK/ERK pathway might be involved in the in vivo neurotrophic effects of huperzine A against transient cerebral ischemia and reperfusion...
  25. ncbi Norisoboldine inhibits the production of pro-inflammatory cytokines in lipopolysaccharide-stimulated RAW 264.7 cells by down-regulating the activation of MAPKs but not NF-κB
    Yubin Luo
    Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, China
    Inflammation 33:389-97. 2010
    ..It can be therefore concluded that norisoboldine inhibits the macrophage activation and the resultant production of pro-inflammatory cytokines via down-regulating the activation of MAPKs signaling pathways rather than NF-κB...
  26. ncbi Beta-carboline alkaloids from a Korean tunicate Eudistoma sp
    Weihong Wang
    Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS 80, Seoul, 151 747, Korea
    J Nat Prod 71:163-6. 2008
    ....
  27. ncbi Marine algal pinnatoxins E and F cause neuromuscular block in an in vitro hemidiaphragm preparation
    Shane D Hellyer
    Department of Pharmacology and Toxicology, University of Otago School of Medical Sciences, Dunedin, New Zealand
    Toxicon 58:693-9. 2011
    ..These results show that pinnatoxins E and F block neuromuscular transmission and suggest that observed in vivo muscle paralysis by pinnatoxin is due to selective antagonism of muscle type nicotinic acetylcholine receptors...
  28. pmc Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries
    Tyler A Johnson
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA
    Bioorg Med Chem 20:4348-55. 2012
    ....
  29. pmc Genotypic and chemotypic diversity of Neotyphodium endophytes in tall fescue from Greece
    Johanna E Takach
    Forage Improvement Division, The Samuel Roberts Noble Foundation, Ardmore, Oklahoma, USA
    Appl Environ Microbiol 78:5501-10. 2012
    ..The results from this study provide insight into endophyte germplasm diversity present in living tall fescue populations...
  30. ncbi Hypocholesterolemia of Rhizoma Coptidis alkaloids is related to the bile acid by up-regulated CYP7A1 in hyperlipidemic rats
    Yang Cao
    Key Unit of Modulating Liver to Treat Hyperlipemia SATCM, State Administration of Traditional Chinese Medicine, Institute of Chinese Medicinal Sciences, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Centre, Guangzhou 510006, PR China
    Phytomedicine 19:686-92. 2012
    This study is to investigate the cholesterol-lowering effect and the new mode of action of coptis alkaloids on high lipid diet-induced hyperlipidemic rats...
  31. pmc Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor
    Laurie P Volak
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Drug Metab Dispos 36:1594-605. 2008
    ..Based on these data and expected tissue concentrations of inhibitors, we predict that a p.o. administered curcuminoid/piperine combination is most likely to inhibit CYP3A, CYP2C9, UGT, and SULT metabolism within the intestinal mucosa...
  32. ncbi Acute toxicity of pinnatoxins E, F and G to mice
    Rex Munday
    AgResearch Ltd, Ruakura Research Centre, Private Bag 3123, Hamilton, New Zealand
    Toxicon 60:995-9. 2012
    ....
  33. ncbi RNA targeting by small molecules: Binding of protoberberine, benzophenanthridine and aristolochia alkaloids to various RNA structures
    Gopinatha Suresh Kumar
    Biophysical Chemistry Laboratory, Chemistry Division, CSIR Indian Institute of Chemical Biology, Kolkata 700 032, India
    J Biosci 37:539-52. 2012
    ..b>Alkaloids are a group of natural products with potential therapeutic utility, and very recently, their interaction with ..
  34. ncbi Oxymatrine attenuates intestinal ischemia/reperfusion injury in rats
    Jinpeng Zhao
    Department of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China
    Surg Today 38:931-7. 2008
    ..The objective of this study was to investigate if oxymatrine could attenuate intestinal I/R injury induced in rats...
  35. ncbi Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, Florida 34243, USA
    Eur J Pharmacol 698:145-53. 2013
    ..Overall our data show that the anti-inflammatory activity of anatabine in vitro and in vivo is mediated in part via an inhibition of STAT3 phosphorylation...
  36. ncbi Matrine inhibits breast cancer growth via miR-21/PTEN/Akt pathway in MCF-7 cells
    Lin Qiang Li
    Key Laboratory of Hepatosplenic Surgery, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China
    Cell Physiol Biochem 30:631-41. 2012
    Matrine is one of the major alkaloids extracted from Sophora flavescens and has been used clinically for breast cancer with notable therapeutic efficacy in China. However, the mechanisms are still largely unknown.
  37. ncbi Biologically active substances from amphibians: preliminary studies on anurans from twenty-one genera of Thailand
    John W Daly
    Laboratory of Bioorganic Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, DHHS, NIH, Bldg 8, Rm 1A17, Bethesda, MD 20892 USA
    Toxicon 44:805-15. 2004
    ..of 21 genera of anurans from Thailand have now been investigated for noxious secretions, toxic substances, and alkaloids. Four genera of bufonid toads (Bufo, Ansonia, Leptophryne, Pedostipes) were toxic due to the presence of ..
  38. pmc Methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as a target for bis-indole alkaloids with antibacterial activities
    Roya Zoraghi
    Division of Infectious Diseases, Department of Medicine, University of British Columbia, British Columbia, Vancouver V5Z 3J5, Canada
    J Biol Chem 286:44716-25. 2011
    ..of an extract library of marine invertebrates against MRSA PK resulted in the identification of bis-indole alkaloids of the spongotine (A), topsentin (B, D), and hamacanthin (C) classes isolated from the Topsentia ..
  39. ncbi Anti-inflammatory activity of alkaloids: an update from 2000 to 2010
    Augusto Lopes Souto
    Laboratory of Pharmaceutical Technology, Federal University of Paraiba, 58051 900, João Pessoa PB, Brazil
    Molecules 16:8515-34. 2011
    ..The aim of this review is to review naturally sourced alkaloids with anti-inflammatory effects reported from 2000 to 2010...
  40. ncbi Cytoprotective and immunomodulating properties of piperine on murine splenocytes: an in vitro study
    Neelima Pathak
    Industrial Toxicology Research Centre, Mahatma Gandhi Marg, P Box 80, Lucknow 226001, India
    Eur J Pharmacol 576:160-70. 2007
    ....
  41. pmc Cryptopleurine targets NF-κB pathway, leading to inhibition of gene products associated with cell survival, proliferation, invasion, and angiogenesis
    Hong Ri Jin
    Center for Molecular Cancer Research, Korea Research Institute of Bioscience and Biotechnology, Ochang, Chungbuk, Republic of Korea
    PLoS ONE 7:e40355. 2012
    ....
  42. ncbi Pharmacological basis for the medicinal use of black pepper and piperine in gastrointestinal disorders
    Malik Hassan Mehmood
    Natural Product Research Division, Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi, Pakistan
    J Med Food 13:1086-96. 2010
    ....
  43. ncbi Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update
    S Haaz
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Obes Rev 7:79-88. 2006
    ..Another substance, Citrus aurantium, which contains several compounds including synephrine alkaloids, has been suggested as a safe alternative. This review examines the evidence for safety and efficacy of C...
  44. ncbi Isoquinoline alkaloids from Macleaya cordata active against plant microbial pathogens
    Hao Liu
    College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China
    Nat Prod Commun 4:1557-60. 2009
    ..Br. led to the isolation of four alkaloids, which were identified as sanguinarine (1), chelerythrine (2), protopine (3) and alpha-allocryptopine (4) on the ..
  45. ncbi Matrine improves 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice
    Hong Cheng
    Department of Internal Medicine and Geriatrics, Zhongnan Hospital, Research Center of Digestive Diseases, Wuhan University School of Medicine, Wuhan 430071, PR China
    Pharmacol Res 53:202-8. 2006
    ..Our findings suggest that matrine improves TNBS-induced colitis in mice and the therapeutic mechanism might be related to the reduction of up-regulated colonic TNF-alpha production caused by TNBS...
  46. ncbi DNA-binding affinities and sequence selectivity of quaternary benzophenanthridine alkaloids sanguinarine, chelerythrine, and nitidine
    Li Ping Bai
    School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong
    Bioorg Med Chem 14:5439-45. 2006
    ....
  47. ncbi Piperine inhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma model
    Seung Hyung Kim
    Institute of Traditional Medicine and Bioscience, Daejeon University, Daejeon, Republic of Korea
    J Pharm Pharmacol 61:353-9. 2009
    ....
  48. ncbi Immunomodulatory and antitumor activity of Piper longum Linn. and piperine
    E S Sunila
    Amala Cancer Research Centre, Amalanagar, Thrissur 680 553, Kerala, India
    J Ethnopharmacol 90:339-46. 2004
    ..3%) and piperine (71.4%) on 5th day after immunization. Bone marrow cellularity and alpha-esterase positive cells were also increased by the administration of Piper longum extract and piperine...
  49. ncbi Metabolomic analysis of biofluids from rats treated with Aconitum alkaloids using nuclear magnetic resonance and gas chromatography/time-of-flight mass spectrometry
    Bo Sun
    National Center of Biomedical Analysis, 27 Taiping Road, Beijing 100850, China
    Anal Biochem 395:125-33. 2009
    The Aconitum alkaloids aconitine, mesaconitine, and hypaconitine are the main toxic components in a commonly used traditional Chinese herbal medicine Fu Zi...
  50. ncbi Amaryllidaceae and Sceletium alkaloids
    Zhong Jin
    State Key Laboratory and Institute of Elemento Organic Chemistry, Nankai University, Tianjin, 30001, P R China
    Nat Prod Rep 26:363-81. 2009
    b>Alkaloids from the plants of Amaryllidaceae family consists of an unique class of nitrogen-containing compounds showing diverse and significant biological activities, including anticancer and acetylcholinesterase (AChE) inhibitory ..
  51. ncbi Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents
    Emmanoel Vilaça Costa
    Departamento de Quimica, Universidade Federal de Sergipe, Avenida Marechal Rondon, S N, Rosa Elze, 49100 000, Sao Cristovao, SE, Brazil
    J Nat Prod 73:1180-3. 2010
    Phytochemical investigation of the bark of Guatteria hispida afforded three new alkaloids, 9-methoxy-O-methylmoschatoline (1), 9-methoxyisomoschatoline (2), and isocerasonine (3), along with 10 known alkaloids, 8-oxopseudopalmatine (4), ..
  52. ncbi Alkaloid biosynthesis: metabolism and trafficking
    Jörg Ziegler
    Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada
    Annu Rev Plant Biol 59:735-69. 2008
    b>Alkaloids represent a highly diverse group of compounds that are related only by the occurrence of a nitrogen atom in a heterocyclic ring...
  53. ncbi Piperine is a potent inhibitor of nuclear factor-kappaB (NF-kappaB), c-Fos, CREB, ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells
    C R Pradeep
    Department of Immunology, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala 680 555, India
    Int Immunopharmacol 4:1795-803. 2004
    ..We found that the nuclear translocation of p65, p50, c-Rel subunits of NF-kappaB and other transcription factors such as ATF-2, c-Fos and CREB were inhibited by the treatment of piperine...
  54. ncbi Cytotoxic and antitumor potentialities of aporphinoid alkaloids
    C Stévigny
    Unité d Analyse Chimique et Physico Chimique des Médicaments, Universite Catholique de Louvain, UCL 72 30 CHAM, Av E Mounier 72, 1200 Bruxelles, Belgium
    Curr Med Chem Anticancer Agents 5:173-82. 2005
    ..More than 500 aporphine alkaloids have been isolated from various plant families and many of these compounds display potent cytotoxic activities ..
  55. ncbi Indole alkaloids from Tabernaemontana australis (Muell. Arg) Miers that inhibit acetylcholinesterase enzyme
    Marcelo T Andrade
    Instituto de Quimica, Universidade Federal do Rio de Janeiro, Centro de Tecnologia, Bloco A, Cidade Universitaria, 21945 970 Rio de Janeiro, RJ, Brazil
    Bioorg Med Chem 13:4092-5. 2005
    Ten indole alkaloids from the chloroform extract of stalk of Tabernaemontana australis (Muell. Arg) Miers were tentatively identified by GC-MS, viz...
  56. pmc Integration of deep transcriptome and proteome analyses reveals the components of alkaloid metabolism in opium poppy cell cultures
    Isabel Desgagné-Penix
    Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada
    BMC Plant Biol 10:252. 2010
    Papaver somniferum (opium poppy) is the source for several pharmaceutical benzylisoquinoline alkaloids including morphine, the codeine and sanguinarine...
  57. ncbi The effects of chelidonine on tubulin polymerisation, cell cycle progression and selected signal transmission pathways
    A Panzer
    Department of Physiology, University of Pretoria, South Africa
    Eur J Cell Biol 80:111-8. 2001
    ..Exposure of all cell lines examined to chelidonine leads to activation of the stress-activated protein kinase/jun kinase pathway (SAPK/JNK)...
  58. ncbi Microbial transformation of alkaloids
    Deborah A Rathbone
    Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QT, UK
    Curr Opin Microbiol 5:274-81. 2002
    b>Alkaloids continue to provide mankind with a plethora of medicines, poisons and potions...
  59. ncbi Antimalarial activity of extracts and alkaloids isolated from six plants used in traditional medicine in Mali and Sao Tome
    C Ancolio
    Laboratoire de Pharmacognosie, Faculte de Pharmacie, Marseille, France
    Phytother Res 16:646-9. 2002
    ..Two alkaloids isolated from the active extract of Guiera senegalensis, harman and tetrahydroharman, showed antimalarial ..
  60. ncbi Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4
    Rajinder K Bhardwaj
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, D 70376 Stuttgart, Germany
    J Pharmacol Exp Ther 302:645-50. 2002
    ....
  61. ncbi Antifibrotic effects of matrine on in vitro and in vivo models of liver fibrosis in rats
    J P Zhang
    Department of Biochemical Pharmacy, School of Pharma cy, Second Military Medical University, Shanghai 200433, China
    Acta Pharmacol Sin 22:183-6. 2001
    ..To study the antifibrotic effects of matrine in vitro a nd in vivo...
  62. ncbi Alkaloids from Cynanchum komarovii with inhibitory activity against the tobacco mosaic virus
    T An
    Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071People's Republic of China
    Phytochemistry 58:1267-9. 2001
    ..by spectroscopic methods, was isolated from the aerial parts of Cynanchum komarovii, together with two known alkaloids, 7-demethoxytylophorine (2) and 7-demethoxytylophorine N-oxide (3)...
  63. ncbi Chemical defense of Mediterranean sponges Aplysina cavernicola and Aplysina aerophoba
    Carsten Thoms
    Institut fur Pharmazeutische Biologie, Universitat Dusseldorf, Universitatsstrasse 1, Geb 26 23, D 40225 Dusseldorf, Germany
    Z Naturforsch C 59:113-22. 2004
    The Mediterranean sponges Aplysina aerophoba and A. cavernicola accumulate brominated isoxazoline alkaloids including aplysinamisin-1 (1), aerophobin-2 (2), isofistularin-3 (3) or aerothionin (4) at concentrations up to 10% of their ..
  64. pmc Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae
    Kristy M Hawkins
    Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 210 41, Pasadena, California 91125, USA
    Nat Chem Biol 4:564-73. 2008
    The benzylisoquinoline alkaloids (BIAs) are a diverse class of metabolites that exhibit a broad range of pharmacological activities and are synthesized through plant biosynthetic pathways comprised of complex enzyme activities and ..
  65. pmc Marine antimalarials
    Ernesto Fattorusso
    Dipartimento di Chimica delle Sostanze Naturali, Universita di Napoli Federico II, via D Montesano, 49, I 80131, Napoli, Italy
    Mar Drugs 7:130-52. 2009
    ..The major groups of metabolites include isonitrile derivatives, alkaloids and endoperoxide derivatives...
  66. ncbi Spectroscopic and calorimetric studies on the binding of alkaloids berberine, palmatine and coralyne to double stranded RNA polynucleotides
    Md Maidul Islam
    Biophysical Chemistry Laboratory, Indian Institute of Chemical Biology, Council of Scientific and Industrial Research, Kolkata 700 032, India
    J Phys Chem B 113:1210-24. 2009
    The interaction of two natural protoberberine plant alkaloids berberine and palmatine and a synthetic derivative coralyne to three double stranded ribonucleic acids, poly(A). poly(U), poly(I).poly(C) and poly(C)...
  67. ncbi Matrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562 cells
    Hua Jiang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    Eur J Pharmacol 559:98-108. 2007
    ..These results demonstrate that matrine triggers apoptosis of K562 cells primarily through the mitochondrial pathway and that matrine is a potential anti-tumor drug...
  68. ncbi Gastric and duodenal antiulcer activity of alkaloids: a review
    Heloina de Sousa Falcão
    Laboratorio de Tecnologia Farmaceutica, Universidade Federal da Paraiba, UFPB, Joao Pessoa, PB, Brazil
    Molecules 13:3198-223. 2008
    ..These products usually derive from plant and animal sources that contain active constituents such as alkaloids, flavonoids, terpenoids, tannins and others...
  69. ncbi Black pepper and its pungent principle-piperine: a review of diverse physiological effects
    K Srinivasan
    Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore, India
    Crit Rev Food Sci Nutr 47:735-48. 2007
    ..Piperine, while it is non-genotoxic, has in fact been found to possess anti-mutagenic and anti-tumor influences...
  70. ncbi Antidepressant activity of curcumin: involvement of serotonin and dopamine system
    Shrinivas K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Psychopharmacology (Berl) 201:435-42. 2008
    ..Curcumin is a major active principle of Curcuma longa, one of the widely used preparations in the Indian system of medicine. It is known for its diverse biological actions...
  71. ncbi Anticancer effects of the Chinese medicine matrine on murine hepatocellular carcinoma cells
    Lingdi Ma
    Center Laboratory, The Second Changzhou People s Hospital, The Affiliated Hospital of the Nanjing Medical University, Changzhou, P R China
    Planta Med 74:245-51. 2008
    ..Inhibition of cell proliferation and induction of apoptosis are the likely mechanisms responsible for matrine's antitumor activities...
  72. ncbi Anti-inflammatory effects of 7-methoxycryptopleurine and structure-activity relations of phenanthroindolizidines and phenanthroquinolizidines
    Cheng Wei Yang
    Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, Taiwan, ROC
    Biochem Biophys Res Commun 354:942-8. 2007
    ..Moreover, in general, phenanthroquinolizidines are more potent than their respective phenanthroindolizines...
  73. ncbi Preclinical and clinical development of cyclin-dependent kinase modulators
    A M Senderowicz
    DTP Clinical Trials Unit, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA
    J Natl Cancer Inst 92:376-87. 2000
    ..Thus, modulation of cdk activity is an attractive target for cancer chemotherapy, and several agents that modulate cdk activity are in or are approaching entry into clinical trials...
  74. ncbi Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms
    Song Li
    Laboratory for Brain and Mind, Institute of Neuroinformatics, Dalian University of Technology, Dalian, 116023, China
    Life Sci 80:1373-81. 2007
    ....
  75. ncbi Studies on the in vitro absorption of spice principles--curcumin, capsaicin and piperine in rat intestines
    D Suresh
    Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore, Karnataka 570 020, India
    Food Chem Toxicol 45:1437-42. 2007
    ..7% to 56.1% when the same was present in micelles. In the case of capsaicin and piperine, increase in absorption was 27.8-44.4% and 43.4-57.4%, respectively, when they were present in micelles as compared to its native form...
  76. ncbi Role of the LolP cytochrome P450 monooxygenase in loline alkaloid biosynthesis
    Martin J Spiering
    Department of Plant Pathology, University of Kentucky, 1405 Veterans Drive, Lexington, KY 40546 0312, USA
    Fungal Genet Biol 45:1307-14. 2008
    The insecticidal loline alkaloids, produced by Neotyphodium uncinatum and related endophytes, are exo-1-aminopyrrolizidines with an ether bridge between C-2 and C-7...
  77. ncbi Bisnicalaterines B and C, atropisomeric bisindole alkaloids from Hunteria zeylanica, showing vasorelaxant activity
    Yusuke Hirasawa
    Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    J Org Chem 75:4218-23. 2010
    Two new bisindole alkaloids, bisnicalaterines B and C (1 and 2) consisting of an eburnane and a corynanthe type of skeletons, were isolated from the bark of Hunteria zeylanica...
  78. ncbi Total alkaloids of Sophorea alopecuroides-induced down-regulation of AcrAB-TolC efflux pump reverses susceptibility to ciprofloxacin in clinical multidrug resistant Escherichia coli isolates
    Xuezhang Zhou
    Key Laboratory of the Ministry of Education for the Conservation and Utilization of Special Biological Resources of Western China
    Phytother Res 26:1637-43. 2012
    In this report, total alkaloids extracted from the seeds of Sophorea alopecuroides (TASA) was evaluated against clinical Escherichia coli isolates resistant to four tested antibiotics, ampicillin (AM), amikacin (AN), cefotaxime (CTX) and ..
  79. ncbi The influence of intraoperative pleural perfusion with matrine-cisplatin or cisplatin on stromal cell-derived factor-1 in non-small cell lung cancer patients with subclinical pleural metastasis
    Cheng Liang Yang
    The First Affiliated Hospital, Liaoning University of Chinese Traditional Medicine, No 79 of Chongshan Eastern Road, 110032 Huanggu District, Shenyang, Liaoning Province, China
    Med Oncol 29:574-81. 2012
    ..In addition, cisplatin plus matrine was confirmed as an initial approach for pleural perfusion and was superior to cisplatin alone...
  80. pmc Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus
    Brian D Ames
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States
    Biochemistry 50:8756-69. 2011
    The human pathogen Aspergillus fumigatus makes a series of fumiquinazoline (FQ) peptidyl alkaloids of increasing scaffold complexity using L-Trp, 2 equiv of L-Ala, and the non-proteinogenic amino acid anthranilate as building blocks...
  81. ncbi Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase
    Hyun Ah Jung
    Division of Food Science and Biotechnology, Pukyong National University, Busan 608 737, Korea
    Arch Pharm Res 31:1405-12. 2008
    ..5 microg/mL. In an attempt to identify bioactive components, six quaternary protoberberine-type alkaloids (berberine, palmatine, jateorrhizine, epiberberine, coptisine, and groenlandicine) and one quaternary aporphine-..
  82. ncbi Lamellarins, from A to Z: a family of anticancer marine pyrrole alkaloids
    Christian Bailly
    Inserm UR 524, and Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, IRCL, Place de Verdun, 59045 Lille, France
    Curr Med Chem Anticancer Agents 4:363-78. 2004
    The lamellarins form a group of more than 30 polyaromatic pyrrole alkaloids, isolated from diverse marine organisms, mainly but not exclusively ascidians and sponges...
  83. ncbi Acridone and furoquinoline alkaloids from Teclea gerrardii (Rutaceae: Toddalioideae) of southern Africa
    Alain F Kamdem Waffo
    School of Chemistry, University of KwaZulu Natal, Howard College Campus, 4041, Durban, South Africa
    Phytochemistry 68:663-7. 2007
    ..extract of the stem bark of Teclea gerrardii (Rutaceae: Toddalioideae) has yielded two acridone alkaloids, 3-hydroxy-1-methoxy-N-methylacridone (tegerrardin A) (1) and 3-hydroxy-N-methyl-1-(gamma,gamma-dimethylallyloxy)..
  84. ncbi Analyses of second-generation 'legal highs' in the UK: initial findings
    Simon D Brandt
    School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK
    Drug Test Anal 2:377-82. 2010
    ..These findings also suggest that both consumers and online sellers (unlike manufacturers and wholesalers) are, most likely unknowingly, confronted with the risk of criminalization and potential harm...
  85. ncbi On the sequence of bond formation in loline alkaloid biosynthesis
    Jerome R Faulkner
    Department of Plant Pathology, University of Kentucky, Lexington, 40546 0312, USA
    Chembiochem 7:1078-88. 2006
    Loline alkaloids are saturated pyrrolizidines with an oxygen bridge between carbon atoms C-2 and C-7 and an amino group on C-1...
  86. ncbi Norisoboldine inhibits the production of interleukin-6 in fibroblast-like synoviocytes from adjuvant arthritis rats through PKC/MAPK/NF-κB-p65/CREB pathways
    Zhifeng Wei
    State Key Laboratory of Natural Medicines, Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Tong Jia Xiang, Nanjing 210009, China
    J Cell Biochem 113:2785-95. 2012
    ..It was concluded that preventing IL-6 release from FLS might be an important mechanism for NOR displaying anti-RA property, and the action of NOR was relative to inhibition of PKC/MAPKs/p65/CREB pathways...
  87. ncbi Suppression of tumor-induced angiogenesis by taspine isolated from Radix et Rhizoma Leonticis and its mechanism of action in vitro
    Yanmin Zhang
    School of Medicine, Xi an Jiaotong University, Shaanxi Province, China
    Cancer Lett 262:103-13. 2008
    ..The result indicated that taspine inhibited HUVEC migration in a dose-dependent manner. These findings suggest that taspine might be a promising candidate as angiogenesis inhibitors...
  88. ncbi Vasorelaxing alkaloids and flavonoids from Cassytha filiformis
    Tung Hu Tsai
    Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
    J Nat Prod 71:289-91. 2008
    Two new aporphine alkaloids, isofiliformine ( 1) and cassythic acid ( 3), along with 22 known compounds were isolated from whole herb of Cassytha filiformis...
  89. ncbi Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide
    Xin Gao
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi Tech Park, Shanghai 201203, People s Republic of China
    Free Radic Biol Med 46:1454-62. 2009
    ..These direct effects on mitochondria further extend the noncholinergic functions of HupA...
  90. ncbi Isoquinoline alkaloids and their binding with polyadenylic acid: potential basis of therapeutic action
    Prabal Giri
    Biophysical Chemistry Laboratory, Indian Institute of Chemical Biology IICB, Kolkata 700032, West Bengal, India
    Mini Rev Med Chem 10:568-77. 2010
    ..Isoquinoline group of alkaloids have their importance in contemporary biomedical research and drug discovery programme due to extensive ..
  91. ncbi Matrine inhibits proliferation and induces apoptosis of pancreatic cancer cells in vitro and in vivo
    Tianyou Liu
    Department of General Surgery, China Japan Friendship Hospital of Jilin University, Changchun 130033, China
    Biol Pharm Bull 33:1740-5. 2010
    ..These results indicate matrine may be a potential and promising agent of natural resource to treat pancreatic cancer...
  92. ncbi The novel proapoptotic activity of nonnatural enantiomer of Lentiginosine
    Beatrice Macchi
    Department of Neuroscience, University of Rome Tor Vergata Via Montpellier 1 Rome 00133 and IRCCS S Lucia, Via Ardeatina 300 00100 Rome, Italy
    Glycobiology 20:500-6. 2010
    ....
  93. ncbi Antimicrobial activity of Mahonia aquifolium and two of its alkaloids against oral bacteria
    Ursula Rohrer
    Institute of Preventive Dentistry and Oral Microbiology, School of Dental Medicine, University of Basel, Switzerland
    Schweiz Monatsschr Zahnmed 117:1126-31. 2007
    Extracts or alkaloids isolated from Mahonia aquifolium exhibit antimicrobial activity against Gram-positive and Gram-negative bacteria, fungi, and protozoa. In this study the bacteriostatic and bacteriocidal activities of a M...
  94. ncbi Chemopreventive efficacy of curcumin and piperine during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis
    S Manoharan
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India
    Singapore Med J 50:139-46. 2009
    ..Our aim was to investigate the chemopreventive potential of curcumin and piperine during 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis...
  95. pmc Relevant spatial scales of chemical variation in Aplysina aerophoba
    Oriol Sacristán-Soriano
    Center for Advanced Studies of Blanes, Accés a la Cala St Francesc 14, Blanes 17300, Girona, Spain
    Mar Drugs 9:2499-513. 2011
    ..This species contains large concentrations of brominated alkaloids (BAs) that play a number of ecological roles in nature...
  96. ncbi Autophagy is involved in anticancer effects of matrine on SGC-7901 human gastric cancer cells
    Junqiang Zhang
    The Second Hospital of Lanzhou University, Lanzhou 730030, PR China
    Oncol Rep 26:115-24. 2011
    ..These findings indicate that matrine is a potent antitumor agent for treating gastric cancer. The ability of matrine to induce autophagy underlines its potential utility as a new gastric cancer treatment modality...
  97. ncbi Piperine as an inhibitor of the MdeA efflux pump of Staphylococcus aureus
    Zahid Mehmood Mirza
    Department of Biochemistry, Faculty of Science, University of Kashmir, Hazartbal, Srinagar 190 001, India
    J Med Microbiol 60:1472-8. 2011
    ..The combination of piperine with mupirocin in a dermal infection model of mice showed better in vivo efficacy when compared with the commercially available formulation of 2 % mupirocin...
  98. ncbi Piperine protects cisplatin-induced apoptosis via heme oxygenase-1 induction in auditory cells
    Byung Min Choi
    Department of Biochemistry, School of Medicine, Wonkwang University, Iksan, Chonbuk 570 749, Republic of Korea
    J Nutr Biochem 18:615-22. 2007
    ..These results demonstrate that the expression of HO-1 by piperine is mediated by both JNK pathway and Nrf2, and the expression inhibits cisplatin-induced apoptosis in HEI-OC1 cells...
  99. ncbi Amaryllidaceae and Sceletium alkaloids
    Zhong Jin
    State Key Laboratory and Institute of Elemento Organic Chemistry, Nankai University, Tianjin 300071, P R China
    Nat Prod Rep 24:886-905. 2007
    A great number of natural products, especially alkaloids, which exhibit a range of biological activities including acetylcholinesterase inhibition and antineoplastic, cardiovascular and immunostimulatory activities, have been isolated ..
  100. ncbi A novel endophytic Huperzine A-producing fungus, Shiraia sp. Slf14, isolated from Huperzia serrata
    D Zhu
    Key Laboratory of Protection and Utilization of Subtropic Plant Resources of Jiangxi Province, Jiangxi Normal University, Nanchang, China
    J Appl Microbiol 109:1469-78. 2010
    ..To characterize and identify a novel Huperzine A (HupA)-producing fungal strain Slf14 isolated from Huperzia serrata (Thunb. ex Murray) Trev. in China...
  101. ncbi Synergistic antibacterial and antibiotic effects of bisbenzylisoquinoline alkaloids on clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA)
    Guo Ying Zuo
    Research Center for Natural Medicines, Kunming General Hospital, PLA, Kunming 650032, China
    Molecules 16:9819-26. 2011
    The antibacterial activity of two bisbenzylisoquinoline alkaloids, tetrandrine (Tet) and demethyltetrandrine (d-Tet), alone and in combination with the antibiotics ampicillin (AMP), azithromycin (AZM), cefazolin (CFZ) and levofloxacin (..

Research Grants67

  1. ASYMMETRIC SYNTHESIS OF BIOACTIVE PRIMARY AMINES
    FRANKLIN DAVIS; Fiscal Year: 2006
    ..Relevant examples include proteinogenic and nonproteinogenic alpha- and beta-amino acids and diverse alkaloids. Such amines are also widely used as chiral building blocks for the enantioselective construction of bioactive ..
  2. A3AR agonists to prevent chemotherapy-induced painful peripheral neuropathy
    Daniela Salvemini; Fiscal Year: 2013
    ..g., paclitaxel), platinum-complex (e.g., oxaliplatin), vinca alkaloids (e.g., vincristine) &proteasome-inhibitor (e.g., bortezomib) classes...
  3. The Effect of Genetic Diversity on Mechanism-Based Inactivation of CYP2D6
    Laura L Furge; Fiscal Year: 2013
    ..enzymes involved in metabolism of steroids, vitamins, eiconsanoids, and xenobiotics such as drugs, complex plant alkaloids, carcinogens, and other small molecules...
  4. DRUG DEPENDENCE CLINICAL RESEARCH PROGRAM
    Reese T Jones; Fiscal Year: 2013
    ..include nicotine and its metabolites, cocaine, methamphetamine and other phenethylamines, alcohol, MDMA, ephedra alkaloids, caffeine, gamma hydroxybutyrate (GHB), salvinorin, adenosine, and neurosteroids, and opiates...
  5. ISU Vet-LIRN Collaborative Validation of Testing Methods on Animal Diagnostic Spe
    WILSON KIIZA RUMBEIHA; Fiscal Year: 2013
    ..validate tests for which our lab has a unique expertise in including aflatoxins, Ractopamine, ionophores, ergot alkaloids, bromethalin, Cholecalciferol, selenium, coumesterol, zearalenone and cyanotoxins...
  6. New Methods for the Synthesis of Neurological Agents and Other Heterocyclic Molec
    Larry E Overman; Fiscal Year: 2013
    ..Daphniphyllum alkaloids are neurotoxic and target directly the central nervous system, resulting in depression of voluntary movement as ..
  7. Mechanism of Action of L THP as an Alternative Therapy for Cocaine Addiction
    Lee Yuan Liu-Chen; Fiscal Year: 2013
    ..project "Alternative Therapies for Alcohol and Drug Abuse" (P01-AT- 002038) funded by NCCAM, eight isoquinoline alkaloids, including L-tetrahydropalmatine (L-THP), were isolated and characterized from tubers of Corydalis yanhuso, ..
  8. Enzymes of the Vinca Alkaloids
    Aimee Usera; Fiscal Year: 2010
    Catharanthus roseus produces a wealth of biologically active alkaloids including the potent anticancer molecules vincristine and vinblastine and the antihypertension agent ajmalicine. The complex nature of the C...
  9. TOTAL SYNTHESIS AND BIOSYNTHESIS OF BIOACTIVE SUBSTANCES
    Robert Michael Williams; Fiscal Year: 2013
    ..acids (isoleucine, proline, and tryptophan) and mevalonate-derived isoprene moieties to the polycyclic indole alkaloids comprising the paraherquamides, stephacidins, avrainvillamide, notoamides, norgeamides, malbrancheamides and ..
  10. Development of novel small molecule drugs for the treatment of high risk B-ALL
    CATHY A SWINDLEHURST; Fiscal Year: 2013
    ..MDR) to a variety of cytotoxic drugs, including glucocorticoids, L-asparaginase, anthracyclines, and vinca alkaloids (vincristine)...
  11. Discovering a Novel Immunophilin to Lower the Toxicity of Cancer Therapeutics
    Mitchell W Mutz; Fiscal Year: 2012
    ..frequent and often dose limiting side effect of mainstay chemotherapeutics including taxanes, bortezomib, vinca alkaloids, platinum complexes, and newly approved therapeutics such as Eribulin...
  12. BcL-2 Proteins in Mechanism of Anti-mitotic Drug Action
    Timothy C Chambers; Fiscal Year: 2013
    ..Microtubule inhibiting agents (MIAs) including the vinca alkaloids and taxanes are important drugs in the arsenal of cancer chemotherapeutics...
  13. Studies on a Novel Taxane Pump
    Elizabeth Hopper-Borge; Fiscal Year: 2011
    ..substrates, and confer resistance to a wide range of agents including anthracyclines, epipodophyllotoxins, vinca alkaloids, and nucleotide analogs...
  14. Accessing Natural Products from Silent Biosynthetic Pathways
    ROBERT HENRY CICHEWICZ; Fiscal Year: 2012
    ..g., penicillins, echinocandins, cyclosporins, ergot alkaloids, and statins)...
  15. Au/Pt Catalysis in the Synthesis of Elaborate N-Heterocycles: Methodology Develop
    Liming Zhang; Fiscal Year: 2013
    ..are to develop efficient synthetic methods for elaborate N- heterocycles and to apply them in synthesis of alkaloids and their analogs. Specifically, there are two aims: A...
  16. COMBINATORIAL APPROACHES FOR NOVEL ANTICANCER AGENTS
    JOHN LAZO; Fiscal Year: 2009
    ..an established critical target for several clinically active anticancer agents, including the taxanes and vinca alkaloids, and (b) dual specificity phosphatases that have been documented to be novel proto-oncogenes and regulators of ..
  17. Biosynthetic Routes to Drug Development for AIDS Ol Mtb
    James W Sims; Fiscal Year: 2010
    ..The manzamine family of alkaloids has shown promising activity against M. tuberculosis...
  18. Conformation and recognition in microtubule dynamics
    LUKE W RICE; Fiscal Year: 2013
    ..intracellular organization, and are the direct targets of anti-cancer chemotherapeutics like taxol and the Vinca alkaloids. The dynamic properties of MTs are central to their function, and they derive from the biochemical properties of ..
  19. Microtubule Mechanics at the Nanoscale
    DAVID S SEPT; Fiscal Year: 2013
    ..Microtubules are the target of important anticancer drugs such as the vinca alkaloids and taxol (paclitaxel), and are thought to play a role in neurodegenerative diseases such as Alzheimer's...
  20. CELL AND TUMOR GENETICS OF MITOTIC ARREST CHECKPOINTS
    PETER KARL SORGER; Fiscal Year: 2010
    ..to reveal the mechanism off action of important anti-microtubule chemotherapeutics such as taxol and the vinca alkaloids. These compounds provoke the spindle checkpoint, and lesions in the checkpoint are very likely to alter the ..
  21. CHEMICAL SYNTHESIS OF NOVEL NATURAL PRODUCTS
    David Williams; Fiscal Year: 2009
    ..Part II. Zoanthamines. Investigations of this novel class of marine alkaloids describe challenging issues of chemical synthesis toward densely functionalized, polycyclic systems...
  22. SYNTHETIC/MECHANISTIC STUDIES OF BIOACTIVE MARINE AGENTS
    Daniel Romo; Fiscal Year: 2013
    ..Principal aims include a highly unified, enantioselective strategy to the complex, bioactive marine alkaloids palau'amine, axinellamine, and styloguanidine from a common cyclopentane intermediate bearing either cyclic ..
  23. Evolution of Pathways to Pharmaceuticals in the Poppy Family
    Jim Leebens Mack; Fiscal Year: 2010
    ..will be performed with the genes hypothesized to encode enzymes involved in the biosynthesis of medicinal alkaloids. This genetic and biochemical information will be made publicly available in the form of a user-friendly ..
  24. Synthesis of Radiofluorinated PET Imaging Agents
    STEPHEN DIMAGNO; Fiscal Year: 2013
    ..Specific aim 3 is to expand the scope of this synthetic chemistry by providing facile protecting group chemistry that is compatible with late stage radiofluorination of alkaloids.
  25. Phosphine-Catalyzed Annulations and Their Applications
    Ohyun Kwon; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Naturally occurring small organic molecules, such as alkaloids, are isolated in optically active forms...
  26. Managing Medication-induced Constipation in Cancer: A Clinical Trial
    Susan C McMillan; Fiscal Year: 2012
    ..the incidence, distress, and trajectory of constipation among cancer patients receiving opioids and vinca alkaloids, to evaluate the efficacy of the Constipation Treatment Protocol, and to compare management according to dose of ..
  27. Pilot Scale Libraries Inspired by Natural Products
    JEFFREY AUBE; Fiscal Year: 2012
    ..based on a recently reported class of twisted lactams, (3) libraries inspired by synthetic routes toward marine alkaloids of the cylindricine/lepadiformine class, (4) haouamine A analogs, and (5) libraries inspired by the natural ..
  28. Tetrahydroisoquinoline Antitumor Drugs: Synthesis and Biosynthesis
    Robert Michael Williams; Fiscal Year: 2012
    ..The antiproliferative activity of this family of alkaloids is intimately associated with the capacity of these agents to bind to and covalently modify DNA...
  29. Mitigating chemotherapy-induced peripheral neuropathy by augmenting axonal NAD
    Samie R Jaffrey; Fiscal Year: 2013
    ..For example, treatment with NAD markedly delays and reduces sensory axon degeneration elicited by vinca alkaloids, such as vinblastine and vincristine, which are commonly used in cancer chemotherapy...
  30. Impact of cholinergic plant extracts on nociception
    ERIC WIERTELAK; Fiscal Year: 2005
    ..The psychoactive properties of these plants are largely attributed to concentrations of anticholinergic tropane alkaloids such as atropine, scopolamine, hyoscyamine, hyoscine and atroscine...
  31. Novel Approaches for Antitumor and Antiviral Agents
    Barry M Trost; Fiscal Year: 2013
    ..The serine protease inhibitors, the aeruginosins, have potential as antiviral agents. The cyclotryptamine alkaloids exhibit a broad range of biological properties including antitumor, antiviral, antifungal, and analgesic ..
  32. The role of insect sweet taste receptors in detecting sweet and bitter compounds
    Erica Freeman; Fiscal Year: 2013
    ..with mixed stimuli I have found that sweet taste receptors in Drosophila are directly inhibited by bitte alkaloids. This mechanism may be evolutionarily conserved since labellar sweet taste neurons in An. gambiae and Ae...
  33. Synthesis and Study of Natural and Non-natural Antiproliferative Agents
    Andrew G Myers; Fiscal Year: 2013
    ..Among the classes of natural products we are studying are the cortistatins, a family of steroidal alkaloids isolated from a marine sponge that potently inhibit the proliferation of human umbilical vein endothelial cells;..
  34. MODULATION OF MULTIDRUG RESISTANCE BY CYCLOSPORIN A
    Charles Erlichman; Fiscal Year: 1992
    ..determinant of both experimental and clinical resistance to doxorubicin and other anthracyclines, to vinca alkaloids, and to etoposide...
  35. Photoredox Catalysis Applications to Bioactive Compounds
    COREY STEPHENSON; Fiscal Year: 2013
    ..D, deoxybionectin A and plectosphaeroic acid A, achieve the synthesis of heterodimeric bis(pyrroloindoline) alkaloids asperdimin and WIN 64745, undertake the syntheses of a series of indolizidine alkaloids using photoredox- ..
  36. NOVEL PALLADIUM CATALYZED SYNTHESES OF INDOLE ALKALOIDS
    BJORN SODERBERG; Fiscal Year: 2001
    ..of this proposal is to develop short, mild, general, and versatile synthetic routes to polyfunctionalized indole alkaloids. The key step in this methodology is a recently developed, palladium catalyzed, N-heteroannulation reaction of 2-..
  37. Enantioselective Total Synthesis of Marcfortine B via SmI2-mediated C-C Bond Form
    TIMOTHY KUM BENG; Fiscal Year: 2013
    ..reactions between our proposed dienophile and 1,1-disubstituted dienes in the synthesis of prenylated indole alkaloids. Our proposed plan will mark the first enantioselective synthesis of any member of the marcfortine family...
  38. STEREOCONTROLLED SYNTHESIS OF BIOACTIVE ALKALOIDS
    VIRESH RAWAL; Fiscal Year: 2007
    ..is to develop concise, general strategies and methods for the stereoselective synthesis of structurally complex alkaloids. The methods section of the research plan is divided into three broad areas...
  39. Alkaloid Synthesis via Asymmetric C-CN Activation
    Christopher J Douglas; Fiscal Year: 2013
    Within the last few years, our laboratory discovered that important structural motifs in medicinal alkaloids, indoles and piperidines, could be synthesized with extraordinary ease using highly unusual reactivity...
  40. Synthesis of Bioactive Complex Alkaloids
    David Y Gin; Fiscal Year: 2010
    ..In this context, new strategies for the total synthesis of several guanidine-containing complex alkaloids will be explored...
  41. Evaluating New Nicotine Standards for Cigarettes
    Dorothy K Hatsukami; Fiscal Year: 2013
    ..between the threshold dose for maintaining rat nicotine self-administration and the presence of minor alkaloids, beta-carbolines, acetaldehyde, and MAO inhibitors...
  42. Catalytic Methods for Carbon-Carbon and Carbon-Heteroatom Bond Formation
    F D Toste; Fiscal Year: 2013
    ..The latter will be applied to the synthesis of the flinderole alkaloids. Enantioselective intermolecular addition of nucleophiles, either directly to the activated ?-bond or to a ..
  43. Transition metal catalyzed construction of ring systems
    Gerald B Hammond; Fiscal Year: 2012
    ..g. alkaloids) in the search for bioactivity...
  44. Synthesis of Bioactive Alkaloids and Peptides
    David A Evans; Fiscal Year: 2012
    ..Himandridine is one of the most complex members of the Galbulimima family of alkaloids. Historically, the native tribes of Papua New Guinea and Australia have used extracts of the bark of Galbulimima ..
  45. ATP LINKED EFFECTORS OF NA+, K+ ATPASE AND CATARACTS
    MARGARET GARNER; Fiscal Year: 2001
    ..determine the role of the lens Na,K-ATPases and their ATP-linked effectors (H+, Na+, K+, ATP, ADP, and digitalis alkaloids) in cataract formation...
  46. C-N Bond-Forming Methodologies for the Synthesis of Small Molecules and Peptides
    JENNIFER LYNN STOCKDILL; Fiscal Year: 2012
    ..This method will be utilized in the synthesis of the leuconicine family of alkaloids, which reverse vincristine resistance in KB cells...
  47. Synthesis and Biological Evaluation of Natural Product Analogues
    ASHTON T HAMME; Fiscal Year: 2013
    ..natural products isolated from the sponge of Verongida have been intensively studied due to the presence of alkaloids with one, or more bromotyrosine residues...
  48. Organocascade catalysis - total synthesis of Ochrosamine B
    Eduardas Skucas; Fiscal Year: 2012
    ..The B|chi-type ketone 2 is a common structural motif of Aspidosperma and Strychnos family indole alkaloids, such as tubifoline, vindoline and ochrosamine B, which exhibit biological properties across a broad spectrum of ..
  49. New Reactions for Heterocycle Synthesis
    John P Wolfe; Fiscal Year: 2010
    ..The substituted pyrrolidine alkaloids preussin and anisomycin have potent antifungal activity and also exhibit potentially useful antitumor activity...
  50. Annulation Strategies Toward the Total Synthesis of Saxitoxin and Zetekitoxin AB
    Michael R Krout; Fiscal Year: 2011
    ..Guanidinium alkaloids saxitoxin and zetekitoxin AB are potent voltage-gated sodium channel blockers that pose significant synthetic ..
  51. Asymmetric Reactions with Dual-Functional Organocatalysis
    Li Deng; Fiscal Year: 2013
    ..Building on preliminary results revealing the ability of cinchona alkaloids to serve as efficient chiral proton donors, the development of asymmetric dual-functional cooperative ..
  52. Oxazolone Cycloadducts as Heterocyclic Scaffolds for Decahydroquinoline Alkaloid
    Stephen Philip Fearnley; Fiscal Year: 2013
    ..provided by applicant): The central theme of this proposal is the total synthesis of several decahydroquinoline alkaloids. This broad class of natural products is structurally diverse and complex, and many of these alkaloids possess ..
  53. C-N Bond-Forming Methodologies for the Synthesis of Small Molecules and Peptides
    JENNIFER LYNN STOCKDILL; Fiscal Year: 2013
    ..This method will be utilized in the synthesis of the leuconicine family of alkaloids, which reverse vincristine resistance in KB cells...
  54. An Efficient Cascade Approach to the Total Synthesis of (-)-Nakadomarin A
    SUSANN MARIE WINBUSH; Fiscal Year: 2012
    ..novel furan containing 8/5/5/5/15/6 hexacyclic diamine core, a feature previously unobserved in other related alkaloids. (-)-Nakadomarin A exhibits a range of interesting biological activities, most notably its inhibitory activity ..
  55. Natural product Synthesis by Rh Catalyzed {2+2+2} Cycloadditions
    Derek M Dalton; Fiscal Year: 2012
    ..These diazadamantane alkaloids have been used as folk medicines for the treatment of a number of ailments including syphilis and malaria...
  56. Mechanisms of Action of Anti-Mitotic Drugs
    Mary Jordan; Fiscal Year: 2007
    Taxol and the Vinca alkaloids are highly effective cancer chemotherapeutic drugs...
  57. Antitumor Antimitotics That Reverse Tumor Resistance
    Aleem Gangjee; Fiscal Year: 2010
    ..The Vinca alkaloids vincristine and vinblastine as well as Taxol and the taxanes are antitubulin agents used against a wide variety ..
  58. PYRROLIZIDINE ALKALOID TOXICITY, METABOLISM, AND BINDING
    DONALD BUHLER; Fiscal Year: 1990
    Pyrrolizidine alkaloids (PAs) are hepatotoxic and carcinogenic alkaloids produced by Senecio and a number of other plant genera...
  59. NOVEL ROUTES TO PHYSIOLOGICALLY ACTIVE COMPOUNDS
    K Vollhardt; Fiscal Year: 1991
    ..and nitriles to give specifically substituted arenes and heteroarenes, including aromatic steroids and ergot alkaloids. The cyclization of specifically constructed enediynes should open up ready access to the natural product ..
  60. ALKALOID SYNTHESIS USING ORGANORHODIUM CHEMISTRY
    MARIE KRAFFT; Fiscal Year: 1992
    ..The Amaryllidaceae alkaloids display a wide range of biological activity...
  61. Development of Natural Product Based Opioid Receptor Ligands
    ANDREW MICHAEL HARNED; Fiscal Year: 2013
    ..It has been hypothesized that the hasubanan alkaloids (HB alkaloids) may meet this long-standing need...
  62. HUMAN MULTIDRUG RESISTANCE--PGLYCOPROTEIN GENES
    IGOR RONINSON; Fiscal Year: 1992
    ..important clinical problem since it involves resistance to many commonly used anticancer agents, including Vinca alkaloids, anthracyclines and epypodophyllotoxins...
  63. Role of the Acetyltransferase p300 in Cellular Responses
    Maria Avantaggiati; Fiscal Year: 2006
    ..Anti-microtubule drugs of clinical relevance include paclitaxel (taxol), vinca alkaloids (vinblastin and vincrisitn), nocodazole and colchicine...
  64. Biosynthesis and bioengineering of the marine anti-tumor compounds, ammosamides A
    Peter A Jordan; Fiscal Year: 2013
    ..The pyrroloquinoline alkaloids are a diverse class of natural products which exhibit broad biological activity...
  65. PHARMACOKINETICS AND PHARMACODYNAMICS OF NICOTINE
    Neal Benowitz; Fiscal Year: 2002
    ..Chemistry studies will include (a) developing methodology for quantitative analysis of tobacco alkaloids and metabolites and applying these methods to qualitatively and quantitatively define pathways of metabolism in ..
  66. Canthinones as Human Isozyme Selective PDE4 Inhibitors
    KEVIN CZERWINSKI; Fiscal Year: 2002
    ..research is to investigate the inhibitory activity of substituted canthin-6-one and canthin-5, 6-dione indole alkaloids against human cAMP phosphodiesterase (PDE4) isoenzymes...
  67. NATURAL SUBSTRATES AND INHIBITORS OF MICROBIAL MDR PUMPS
    Kim Lewis; Fiscal Year: 2002
    ..According to our findings, berberine alkaloids are natural MDR substrates...